_:b288781445 . . . . _:b288781317 . . _:b288781355 . _:b288781425 . _:b288781354 . . . . _:b288781436 . _:b288781389 . . _:b288781325 . . _:b288781337 . . . . _:b732985 . _:b288781370 . _:b288781366 . . _:b732983 . _:b288781323 . _:b732993 . _:b288781373 . . _:b732978 "In contrast, other studies have not confirmed weight loss as prognostic for either NSCLC (O\u2019Connell et al, 1986; Sorensen et al, >>1989<<; Paesmans et al, 1995), SCLC (Paesmans et al, 2000; Christodolou et al, 2002), or mesothelioma (Curran et al, 1998)." . _:b732984 . . . _:b732976 "and has been identified as a prognostic factor in NSCLC (Dewys et al, 1980; Stanley, 1980; Hoeltgen et al, 1983), SCLC (Dewys et al, 1980; Wolf et al, 1991; Bremnes et al, 2003) and mesothelioma (Herndon et al, 1998; Edwards et al, >>2000<<). In contrast, other studies have not confirmed weight loss as prognostic for either NSCLC (O\u2019Connell et al, 1986; Sorensen et al, 1989; Paesmans et al, 1995), SCLC (Paesmans et al, 2000; Christodolou et al, 2002), or mesothelioma (Curran" . _:b288781447 . . _:b732997 . . _:b732973 "Weight loss is recognised to occur frequently and has been identified as a prognostic factor in NSCLC (Dewys et al, 1980; Stanley, 1980; Hoeltgen et al, 1983), SCLC (Dewys et al, 1980; Wolf et al, >>1991<<; Bremnes et al, 2003) and mesothelioma (Herndon et al, 1998; Edwards et al, 2000)." . _:b288781488 . . _:b732974 "Weight loss is recognised to occur frequently and has been identified as a prognostic factor in NSCLC (Dewys et al, 1980; Stanley, 1980; Hoeltgen et al, 1983), SCLC (Dewys et al, 1980; Wolf et al, 1991; Bremnes et al, >>2003<<) and mesothelioma (Herndon et al, 1998; Edwards et al, 2000)." . . _:b288781346 . . . _:b288781405 . . . . . . _:b732974 . _:b732989 _:b732990 . _:b732989 _:b732991 . . _:b288781477 . _:b732991 . _:b732991 "of patients treated for NSCLC were treated within the context of clinical trials with a minimum of three cycles of platinum-containing regimens, including MVP, carboplatin and vinorelbine, and docetaxel plus carboplatin (Ellis et al, >>1995<<; Smith et al, 2001)." . . _:b288781491 . _:b288781484 . _:b732987 . _:b288781386 . _:b288781369 . _:b288781486 . . _:b288781383 . _:b288781453 . _:b288781411 . _:b732989 _:b732992 . _:b732989 _:b732993 . _:b732989 _:b732994 . _:b732989 _:b732995 . _:b732975 . _:b732989 _:b732996 . _:b732989 _:b732997 . . . _:b288781432 . . _:b732970 _:b732972 . . _:b732970 _:b732973 . _:b288781392 . _:b732970 _:b732974 . _:b288781476 . . . _:b732970 _:b732975 . _:b732970 _:b732971 . _:b288781330 . _:b732975 "to occur frequently and has been identified as a prognostic factor in NSCLC (Dewys et al, 1980; Stanley, 1980; Hoeltgen et al, 1983), SCLC (Dewys et al, 1980; Wolf et al, 1991; Bremnes et al, 2003) and mesothelioma (Herndon et al, >>1998<<; Edwards et al, 2000)." . . . _:b288781468 . _:b732970 _:b732988 . . _:b732970 _:b732984 . _:b732970 _:b732985 . _:b732970 _:b732986 . _:b732970 _:b732987 . _:b732970 _:b732980 . _:b732970 _:b732981 . _:b732970 _:b732982 . _:b732970 _:b732983 . . _:b732970 _:b732976 . . _:b288781399 . _:b732970 _:b732977 . _:b732970 _:b732978 . _:b732970 _:b732979 . _:b288781422 . . _:b288781397 . _:b288781470 . _:b288781320 . . _:b288781378 . . . . . . . _:b288781321 . . . _:b288781441 . . _:b732997 "SCLC were treated with six cycles of established regimens (Adriamycin, cyclophosphamide and etoposide; ifosfamide, carboplatin and etoposide; carboplatin plus etoposide; MVP) (Smith et al, 1987, 1990; Jones et al, 1991; Hickish et al, >>1998<<). Mesothelioma was treated with four cycles of MVP chemotherapy (Middleton et al, 1998)." . . _:b288781364 . _:b288781319 "10"^^ . _:b288781490 . _:b288781497 . _:b288781495 . . _:b288781318 "12"^^ . . _:b288781379 . . _:b288781324 . . . . _:b288781317 "15"^^ . . _:b288781398 . _:b288781316 "25"^^ . _:b288781375 . _:b288781326 "6"^^ . . _:b288781324 "7"^^ . _:b288781327 "5"^^ . _:b288781325 "6"^^ . _:b732972 . . _:b288781322 "8"^^ . _:b288781339 . _:b288781317 . _:b288781323 "7"^^ . _:b288781472 . _:b288781316 . . _:b288781320 "10"^^ . _:b288781319 . _:b288781321 "9"^^ . _:b288781318 . _:b288781333 "4"^^ . _:b288781494 . _:b288781404 . _:b288781332 "4"^^ . _:b288781341 . _:b288781335 "4"^^ . _:b288781332 . _:b288781333 . _:b288781334 . . _:b288781334 "4"^^ . _:b288781335 . _:b288781328 . _:b288781329 . _:b288781319 . _:b288781330 . _:b288781331 . _:b288781329 "5"^^ . _:b288781340 . . _:b288781428 . _:b288781341 . _:b288781325 . _:b288781342 . . _:b288781343 . _:b288781328 "5"^^ . _:b732988 . _:b732980 . _:b288781336 . . _:b288781337 . _:b288781324 . _:b288781338 . _:b288781331 "4"^^ . _:b288781339 . _:b288781316 . _:b288781317 . _:b288781327 . _:b288781318 . . _:b288781319 . _:b288781330 "5"^^ . _:b288781363 . "10.1038%2Fsj.bjc.6601781" . _:b288781326 . _:b288781341 "4"^^ . _:b288781324 . _:b288781493 . _:b288781325 . _:b288781321 . _:b288781326 . _:b288781340 "4"^^ . _:b288781327 . _:b288781320 . _:b288781321 . _:b288781320 . _:b288781322 . _:b288781360 . _:b288781343 "4"^^ . _:b288781323 . _:b288781364 . . . _:b288781365 . _:b288781323 . _:b288781366 . _:b288781342 "4"^^ . _:b288781367 . _:b288781360 . _:b288781361 . _:b288781322 . _:b732987 "A number of studies have evaluated enteral (Evans et al, 1987; Ovesen et al., 1993) and parenteral (Klein et al., 1986; McGeer et al., >>1990<<) nutritional support in patients receiving treatment for cancer and suggested no benefit from such interventions." . _:b288781362 . _:b288781337 "4"^^ . _:b288781363 . _:b288781372 . _:b288781373 . . _:b288781333 . _:b732992 "for NSCLC were treated within the context of clinical trials with a minimum of three cycles of platinum-containing regimens, including MVP, carboplatin and vinorelbine, and docetaxel plus carboplatin (Ellis et al, 1995; Smith et al, >>2001<<). In addition, 11 patients with NSCLC were treated with single agent vinorelbine on the basis of the results of the Elderly Lung Cancer Vinorelbine Italian Study Group (The Elderly Lung Cancer Vinorelbine Italian Study (ELVIS) Group," . _:b288781374 . _:b288781336 "4"^^ . _:b288781375 . _:b288781368 . _:b732971 "Weight loss is recognised to occur frequently and has been identified as a prognostic factor in NSCLC (Dewys et al, 1980; Stanley, >>1980<<; Hoeltgen et al, 1983), SCLC (Dewys et al, 1980; Wolf et al, 1991; Bremnes et al, 2003) and mesothelioma (Herndon et al, 1998; Edwards et al, 2000)." . _:b288781369 . . _:b288781332 . _:b288781464 . _:b288781370 . _:b288781339 "4"^^ . _:b288781371 . . _:b288781348 . _:b288781349 . _:b288781335 . _:b288781350 . _:b288781338 "4"^^ . _:b288781351 . _:b288781344 . . _:b288781345 . _:b288781334 . _:b288781346 . _:b288781349 "3"^^ . _:b288781356 . _:b288781347 . _:b288781356 . _:b288781357 . _:b288781329 . . _:b288781358 . _:b288781348 "3"^^ . _:b288781359 . _:b288781352 . _:b288781400 . _:b288781353 . _:b288781328 . _:b288781457 . _:b288781354 . _:b288781351 "3"^^ . _:b288781355 . _:b732992 . _:b288781396 . _:b288781397 . _:b288781331 . _:b288781398 . _:b288781350 "3"^^ . _:b288781399 . _:b288781392 . . . _:b288781393 . _:b288781330 . _:b288781394 . _:b288781334 . _:b288781395 . _:b288781345 "4"^^ . _:b288781404 . _:b732986 "A number of studies have evaluated enteral (Evans et al, 1987; Ovesen et al., 1993) and parenteral (Klein et al., >>1986<<; McGeer et al., 1990) nutritional support in patients receiving treatment for cancer and suggested no benefit from such interventions." . _:b288781405 . _:b288781341 . _:b288781406 . _:b288781344 "4"^^ . _:b288781407 . _:b288781400 . _:b288781401 . _:b288781340 . _:b288781402 . _:b288781347 "3"^^ . _:b288781403 . . _:b288781380 . _:b288781381 . _:b732994 . _:b288781343 . _:b288781382 . _:b288781346 "3"^^ . _:b288781383 . _:b288781376 . . _:b288781377 . _:b288781342 . _:b288781378 . _:b288781357 "3"^^ . _:b288781379 . . _:b288781388 . _:b288781389 . _:b288781337 . _:b288781390 . _:b288781356 "3"^^ . _:b288781391 . _:b288781384 . . _:b288781385 . _:b288781336 . _:b288781413 . . _:b288781386 . _:b288781359 "3"^^ . _:b288781387 . _:b288781428 . _:b288781438 . _:b288781429 . _:b288781339 . _:b288781430 . _:b288781358 "3"^^ . _:b288781431 . _:b288781424 . _:b288781425 . _:b288781338 . _:b288781426 . _:b288781353 "3"^^ . _:b288781427 . _:b288781436 . _:b288781437 . _:b288781349 . _:b288781438 . _:b288781352 "3"^^ . _:b288781439 . _:b288781432 . _:b288781492 . _:b288781433 . _:b288781348 . _:b288781496 . _:b288781434 . _:b288781355 "3"^^ . _:b288781435 . _:b288781412 . _:b288781413 . . _:b288781412 . _:b288781414 . _:b288781354 "3"^^ . _:b288781351 . _:b288781415 . _:b288781408 . _:b288781409 . _:b288781350 . . _:b288781410 . _:b288781365 "3"^^ . _:b288781411 . . _:b288781420 . _:b288781421 . _:b288781345 . _:b288781422 . _:b288781364 "3"^^ . _:b288781423 . _:b288781416 . . _:b288781417 . _:b288781481 . _:b288781371 . _:b288781418 . _:b288781367 "3"^^ . _:b288781344 . _:b288781419 . _:b288781460 . . . _:b288781461 . _:b288781347 . _:b288781462 . _:b288781366 "3"^^ . _:b288781463 . _:b288781456 . _:b288781457 . _:b288781346 . _:b288781458 . _:b288781361 "3"^^ . _:b288781459 . _:b288781381 . _:b288781345 . _:b288781468 . _:b288781469 . _:b288781357 . _:b288781470 . _:b288781360 "3"^^ . . _:b288781471 . _:b288781464 . _:b288781465 . _:b288781356 . _:b288781466 . _:b288781363 "3"^^ . _:b288781467 . _:b288781444 . _:b288781338 . _:b288781445 . _:b288781483 . _:b288781359 . _:b288781446 . _:b288781362 "3"^^ . _:b288781447 . _:b288781440 . _:b288781373 "2"^^ . _:b288781441 . _:b288781358 . _:b288781442 . _:b288781443 . _:b732990 . _:b288781452 . _:b288781372 "2"^^ . _:b288781453 . _:b288781394 . _:b288781456 . _:b288781418 . _:b288781454 . _:b288781353 . _:b288781455 . _:b288781448 . _:b288781375 "2"^^ . _:b288781471 . _:b288781449 . _:b288781352 . _:b288781450 . _:b288781451 . _:b288781492 . _:b288781374 "2"^^ . _:b288781493 . _:b288781355 . _:b288781494 . _:b288781495 . _:b288781488 . _:b288781451 . _:b288781489 . _:b732976 . _:b288781354 . _:b288781490 . _:b288781369 "3"^^ . _:b288781491 . _:b288781365 . _:b288781368 "3"^^ . . _:b288781496 . _:b288781497 . _:b288781364 . _:b288781371 "3"^^ . _:b288781476 . _:b288781347 . _:b288781477 . _:b288781367 . _:b288781478 . _:b288781370 "3"^^ . _:b288781479 . _:b732993 "In addition, 11 patients with NSCLC were treated with single agent vinorelbine on the basis of the results of the Elderly Lung Cancer Vinorelbine Italian Study Group (The Elderly Lung Cancer Vinorelbine Italian Study (ELVIS) Group, >>1999<<). Patients with SCLC were treated with six cycles of established regimens (Adriamycin, cyclophosphamide and etoposide; ifosfamide, carboplatin and etoposide; carboplatin plus etoposide; MVP) (Smith et al, 1987, 1990; Jones et al, 1991;" . _:b288781472 . _:b288781381 "2"^^ . _:b288781473 . _:b288781366 . _:b288781361 . _:b288781474 . . _:b288781475 . _:b288781484 . _:b288781380 "2"^^ . _:b288781485 . _:b288781361 . _:b288781486 . _:b288781487 . _:b288781329 . _:b288781480 . _:b288781358 . _:b288781383 "2"^^ . _:b288781481 . _:b288781360 . _:b288781482 . _:b288781483 . _:b288781382 "2"^^ . _:b288781363 . _:b288781343 . _:b288781450 . _:b288781377 "2"^^ . _:b288781362 . _:b288781382 . _:b288781376 "2"^^ . _:b288781373 . _:b288781379 "2"^^ . . . _:b288781408 . _:b288781372 . _:b288781378 "2"^^ . _:b288781375 . _:b288781389 "2"^^ . _:b288781423 . . _:b288781374 . . _:b732971 . _:b288781388 "2"^^ . _:b288781429 . _:b288781369 . _:b288781391 "2"^^ . _:b288781368 . _:b288781467 . _:b288781336 . . _:b288781390 "2"^^ . _:b288781371 . _:b288781351 . _:b288781385 "2"^^ . . _:b288781370 . _:b288781318 . . _:b288781384 "2"^^ . _:b288781381 . . _:b288781348 . _:b288781387 "2"^^ . _:b288781380 . _:b288781386 "2"^^ . _:b288781383 . _:b288781461 . _:b288781397 "2"^^ . _:b288781382 . . _:b288781409 . _:b288781396 "2"^^ . _:b288781377 . . _:b288781399 "2"^^ . _:b288781376 . . _:b288781398 "2"^^ . _:b288781379 . _:b732986 . _:b288781372 . _:b288781419 . . _:b288781393 "2"^^ . _:b288781378 . . . _:b288781392 "2"^^ . _:b288781389 . _:b288781480 . _:b288781395 "2"^^ . _:b288781388 . _:b288781394 "2"^^ . _:b288781469 . _:b288781322 . . _:b288781391 . _:b288781405 "2"^^ . . _:b288781390 . _:b288781427 . _:b288781439 . _:b288781442 . _:b288781404 "2"^^ . _:b288781385 . _:b288781353 . _:b288781402 . _:b288781407 "2"^^ . _:b288781384 . . _:b288781406 "2"^^ . _:b288781387 . _:b288781401 "2"^^ . _:b288781386 . _:b288781400 "2"^^ . _:b288781397 . . . _:b288781403 "2"^^ . _:b288781396 . _:b288781331 . _:b288781402 "2"^^ . _:b288781399 . . _:b288781413 "2"^^ . _:b288781398 . _:b288781412 "2"^^ . _:b288781393 . _:b288781415 "2"^^ . _:b288781473 . _:b288781392 . . _:b288781414 "2"^^ . _:b288781395 . . . _:b288781374 . _:b288781409 "2"^^ . . _:b288781394 . _:b288781408 "2"^^ . . _:b288781405 . _:b732970 "discussion" . . _:b288781411 "2"^^ . _:b288781404 . . . . _:b288781410 "2"^^ . _:b288781407 . _:b288781437 . . . _:b288781424 . _:b288781421 "2"^^ . _:b288781406 . . _:b288781440 . _:b288781420 "2"^^ . _:b288781401 . _:b288781423 "2"^^ . _:b288781400 . . _:b288781422 "2"^^ . _:b288781403 . _:b288781449 . _:b732982 . _:b288781417 "2"^^ . _:b288781380 . _:b288781474 . _:b288781402 . _:b288781416 "2"^^ . _:b288781413 . . _:b288781419 "2"^^ . _:b288781412 . _:b732983 "this hypothesis is suggested by a study indicating that weight loss in SCLC is associated with a greater increase in resting energy expenditure adjusted for fat-free mass than NSCLC associated weight loss (Staal-van den Brekel et al, >>1997<<). This suggests changes in carbohydrate compared with fat metabolism specifically related to the biology of SCLC." . . _:b288781418 "2"^^ . _:b288781415 . _:b288781429 "2"^^ . _:b288781414 . _:b288781428 "2"^^ . _:b288781409 . _:b288781434 . . _:b732977 . _:b288781431 "2"^^ . _:b732978 . "PMC0" . _:b288781408 . _:b288781396 . . _:b288781430 "2"^^ . _:b288781411 . . _:b288781425 "2"^^ . . _:b288781410 . _:b288781424 "2"^^ . _:b288781421 . _:b732996 . _:b288781427 "2"^^ . _:b288781454 . _:b288781420 . _:b288781426 "2"^^ . _:b288781423 . _:b288781390 . _:b288781437 "2"^^ . _:b288781422 . _:b288781430 . _:b288781436 "2"^^ . _:b288781417 . _:b288781439 "2"^^ . _:b288781416 . . _:b288781438 "2"^^ . _:b288781419 . _:b288781403 . . _:b288781433 "2"^^ . _:b288781418 . . . _:b288781432 "2"^^ . _:b288781429 . _:b288781435 "2"^^ . _:b288781328 . _:b288781428 . _:b732973 . _:b288781434 "2"^^ . _:b288781431 . _:b288781445 "2"^^ . _:b288781430 . _:b288781444 "2"^^ . _:b288781395 . _:b288781425 . . . . _:b288781447 "2"^^ . _:b288781424 . . . _:b288781446 "2"^^ . _:b288781427 . _:b288781342 . . _:b288781441 "2"^^ . _:b288781426 . _:b288781475 . _:b288781440 "2"^^ . _:b288781437 . . . _:b288781443 "2"^^ . _:b288781420 . _:b288781436 . _:b288781384 . . _:b288781442 "2"^^ . . _:b288781439 . _:b732970 . _:b288781453 "2"^^ . . _:b732985 "A number of studies have evaluated enteral (Evans et al, 1987; Ovesen et al., >>1993<<) and parenteral (Klein et al., 1986; McGeer et al., 1990) nutritional support in patients receiving treatment for cancer and suggested no benefit from such interventions." . _:b288781438 . . _:b288781433 . _:b288781452 "2"^^ . . _:b288781433 . _:b288781401 . _:b732989 . _:b288781455 "2"^^ . _:b288781432 . _:b288781489 . . _:b288781444 . _:b288781454 "2"^^ . _:b288781435 . . _:b288781449 "2"^^ . _:b288781434 . _:b288781448 "2"^^ . _:b288781445 . . _:b288781451 "2"^^ . _:b288781444 . _:b288781421 . _:b288781393 . _:b288781450 "2"^^ . _:b288781447 . . _:b288781461 "2"^^ . _:b288781446 . _:b288781459 . _:b288781460 "2"^^ . _:b288781441 . _:b288781327 . _:b288781340 . _:b288781463 "2"^^ . _:b288781368 . _:b288781440 . _:b288781462 "2"^^ . _:b288781443 . _:b288781457 "2"^^ . _:b288781442 . _:b288781456 "2"^^ . _:b288781453 . . . . _:b288781459 "2"^^ . _:b288781452 . _:b288781458 "2"^^ . _:b288781455 . . _:b288781469 "2"^^ . . _:b288781454 . . _:b288781452 . _:b288781460 . _:b288781468 "2"^^ . _:b288781449 . _:b732979 . _:b732982 "other studies have not confirmed weight loss as prognostic for either NSCLC (O\u2019Connell et al, 1986; Sorensen et al, 1989; Paesmans et al, 1995), SCLC (Paesmans et al, 2000; Christodolou et al, 2002), or mesothelioma (Curran et al, >>1998<<). This study has demonstrated that weight loss at presentation is an independent prognostic factor for survival of patients\u2019 with NSCLC, SCLC and mesothelioma." . _:b288781471 "2"^^ . _:b732972 "Weight loss is recognised to occur frequently and has been identified as a prognostic factor in NSCLC (Dewys et al, 1980; Stanley, 1980; Hoeltgen et al, >>1983<<), SCLC (Dewys et al, 1980; Wolf et al, 1991; Bremnes et al, 2003) and mesothelioma (Herndon et al, 1998; Edwards et al, 2000)." . _:b288781448 . _:b732972 . _:b288781470 "2"^^ . _:b288781406 . _:b288781451 . . _:b732995 . _:b732973 . _:b288781359 . _:b288781465 "2"^^ . _:b288781450 . . _:b732974 . . _:b288781464 "2"^^ . _:b732994 "Patients with SCLC were treated with six cycles of established regimens (Adriamycin, cyclophosphamide and etoposide; ifosfamide, carboplatin and etoposide; carboplatin plus etoposide; MVP) (Smith et al, >>1987<<, 1990; Jones et al, 1991; Hickish et al, 1998)." . _:b288781461 . _:b732975 . _:b288781350 . . _:b288781387 . _:b288781467 "2"^^ . _:b288781460 . _:b288781462 . _:b732990 "The rationale for a 63 day period for this assessment is that patients treated for NSCLC are currently treated with three cycles of chemotherapy following the findings of Smith et al (>>2001<<) that survival was similar for patients treated with three or six cycles of mitomycin, vinblastine and cisplatin (MVP)." . . _:b288781466 "2"^^ . . _:b288781485 . _:b288781463 . _:b288781365 . _:b288781477 "2"^^ . _:b288781462 . _:b732970 . _:b288781362 . _:b288781476 "2"^^ . _:b288781457 . _:b732971 . _:b288781479 "2"^^ . . _:b288781456 . _:b732980 . _:b732988 "Intriguingly, we have previously observed that a nadir haemoglobin level less than 12\u2009g\u2009dl\u22121 during chemotherapy treatment for SCLC and NSCLC was associated with poorer survival (Waters et al., >>2002<<). Thus, the increased incidence of chemotherapy-related anaemia in patients with weight loss may contribute to the inferior survival." . _:b732984 "A number of studies have evaluated enteral (Evans et al, >>1987<<; Ovesen et al., 1993) and parenteral (Klein et al., 1986; McGeer et al., 1990) nutritional support in patients receiving treatment for cancer and suggested no benefit from such interventions." . _:b288781478 "2"^^ . _:b288781459 . _:b732981 . _:b288781473 "2"^^ . . _:b288781458 . . _:b732982 . . _:b288781414 . _:b288781472 "2"^^ . _:b288781469 . _:b732983 . _:b288781475 "2"^^ . _:b288781468 . _:b732976 . _:b288781474 "2"^^ . _:b288781471 . _:b732977 . . . _:b288781485 "2"^^ . _:b288781470 . _:b732978 . _:b288781326 . _:b288781484 "2"^^ . . _:b288781465 . _:b288781479 . _:b732979 . _:b288781463 . . _:b288781487 "2"^^ . _:b288781464 . _:b732988 . _:b288781486 "2"^^ . _:b288781467 . _:b732989 . . . . _:b288781481 "2"^^ . . _:b288781466 . _:b732990 . _:b288781480 "2"^^ . _:b288781477 . _:b732991 . . _:b288781483 "2"^^ . _:b288781476 . _:b732984 . _:b288781332 . _:b288781482 "2"^^ . _:b288781479 . _:b732985 . . . _:b288781493 "2"^^ . _:b288781478 . _:b732986 . . _:b288781492 "2"^^ . . _:b288781473 . _:b732987 . _:b288781333 . _:b288781495 "2"^^ . _:b288781472 . . _:b732996 . . _:b288781352 . _:b288781494 "2"^^ . _:b288781475 . _:b732997 . _:b288781489 "2"^^ . _:b288781474 . . . _:b288781488 "2"^^ . _:b288781485 . _:b288781491 "2"^^ . . _:b288781484 . _:b732992 . _:b288781490 "2"^^ . _:b288781487 . _:b732993 . . _:b288781486 . _:b732994 . . . . _:b288781481 . _:b288781385 . _:b732995 . . _:b288781480 . _:b288781483 . _:b288781446 . _:b288781349 . . _:b288781497 "2"^^ . _:b288781391 . _:b288781482 . _:b288781458 . . _:b288781496 "2"^^ . _:b288781493 . _:b288781367 . _:b288781492 . _:b288781435 . _:b288781416 . _:b288781495 . _:b288781448 . _:b288781494 . . _:b732996 "Patients with SCLC were treated with six cycles of established regimens (Adriamycin, cyclophosphamide and etoposide; ifosfamide, carboplatin and etoposide; carboplatin plus etoposide; MVP) (Smith et al, 1987, 1990; Jones et al, >>1991<<; Hickish et al, 1998)." . _:b288781426 . _:b288781489 . . _:b288781488 . _:b732977 "In contrast, other studies have not confirmed weight loss as prognostic for either NSCLC (O\u2019Connell et al, >>1986<<; Sorensen et al, 1989; Paesmans et al, 1995), SCLC (Paesmans et al, 2000; Christodolou et al, 2002), or mesothelioma (Curran et al, 1998)." . _:b288781407 . _:b288781491 . . _:b288781344 . _:b288781490 . . _:b288781316 . . . _:b288781388 . _:b732989 "patients and methods" . _:b288781431 . . _:b288781415 . _:b288781497 . _:b288781455 . _:b288781496 . _:b288781443 . . . _:b732995 "Patients with SCLC were treated with six cycles of established regimens (Adriamycin, cyclophosphamide and etoposide; ifosfamide, carboplatin and etoposide; carboplatin plus etoposide; MVP) (Smith et al, 1987, >>1990<<; Jones et al, 1991; Hickish et al, 1998)." . . . . _:b732981 . _:b288781482 . _:b288781410 . . _:b288781376 . . _:b288781357 . . _:b288781466 . . . _:b732979 "In contrast, other studies have not confirmed weight loss as prognostic for either NSCLC (O\u2019Connell et al, 1986; Sorensen et al, 1989; Paesmans et al, >>1995<<), SCLC (Paesmans et al, 2000; Christodolou et al, 2002), or mesothelioma (Curran et al, 1998)." . . . _:b288781465 . _:b288781377 . _:b732981 "In contrast, other studies have not confirmed weight loss as prognostic for either NSCLC (O\u2019Connell et al, 1986; Sorensen et al, 1989; Paesmans et al, 1995), SCLC (Paesmans et al, 2000; Christodolou et al, >>2002<<), or mesothelioma (Curran et al, 1998)." . . _:b288781417 . . _:b288781335 . . _:b732980 "In contrast, other studies have not confirmed weight loss as prognostic for either NSCLC (O\u2019Connell et al, 1986; Sorensen et al, 1989; Paesmans et al, 1995), SCLC (Paesmans et al, >>2000<<; Christodolou et al, 2002), or mesothelioma (Curran et al, 1998)." . _:b288781478 . _:b288781487 .