_:b420267313 . . . . . _:b420266987 . _:b420267024 . _:b420267350 . . _:b420267158 . _:b420267232 . _:b420267264 . . . _:b420267001 . . . _:b420267092 . . _:b420267075 . _:b420267213 . _:b420267319 . . _:b420267304 . _:b420267052 . _:b420267233 . . . . _:b420267298 . _:b420267269 . _:b6567524 "changes. It is the most common type of pre-senile and senile dementia. According to the World Health Organization (WHO), 5% of men and 6% of woman of above the age of 60 years are affected with Alzheimer's type dementia worldwide.[>>1<<] In India, the total prevalence of dementia per 1000 people is 33.6%, of which AD constitutes approximately 54% and vascular dementia constitutes approximately 39%." . . . _:b420267268 . . _:b6567559 "and was observed by electron paramagnetic resonance spectroscopy. In addition, copper chelators could cause a structural transition of A(beta). There was an increase on beta sheet as well as alpha-helix when copper was introduced.[>>31<<] Another study reveals that copper and zinc bind A-beta inducing aggregation and give rise to reactive oxygen species." . _:b420266939 . _:b420267271 . . . . _:b6567529 "[45] Curcumin holds a high place in Ayurvedic medicine as a \u201Ccleanser of the body,\u201D and today, science is finding a growing list of diseased conditions that can be healed by the active ingredients of turmeric.[>>6<<" . . _:b420267380 . _:b420267371 . . _:b420267270 . _:b420267381 . _:b420267376 . _:b420267377 . _:b6567578 "After treatment of macrophages with curcuminoids, A\u03B2 uptake by macrophages of three of the six AD patients was found to have significantly increased (P < 0.001 to 0.081).[>>11<<" . _:b420267265 . . _:b420266936 . _:b420267378 . _:b420267379 . . _:b420267264 . . . _:b420267267 . _:b420267197 . _:b420267364 . . _:b420267266 . _:b420267220 . _:b420267365 . _:b420267366 . _:b420267367 . . _:b420267360 . . _:b420267277 . . . _:b420267361 . _:b420267362 . _:b420267363 . _:b420267057 . _:b420267372 . . _:b420267276 . _:b420267373 . _:b420267374 . _:b420267375 . _:b420267368 . _:b420267369 . _:b420267279 . _:b420267370 . _:b420267371 . _:b420267348 . _:b420267349 . _:b420267278 . _:b420267350 . _:b420267351 . _:b420267344 . _:b420267345 . _:b420267273 . _:b420267346 . _:b420267347 . _:b420267034 . _:b420267356 . _:b420267072 . _:b420267357 . _:b420267272 . _:b420267358 . _:b420267359 . _:b420267352 . _:b420267216 . _:b420267353 . _:b420267275 . . _:b420267354 . . _:b420267355 . _:b420267332 . _:b420267333 . _:b420267375 . _:b420267274 . _:b420267334 . _:b420267335 . _:b6567546 "It decreases the low-density lipoprotein oxidation and the free radicals that cause the deterioration of neurons, not only in AD but also in other neuron degenerative disorders such as Huntington's and Parkinson's disease.[>>16<<] In one study, curcuma oil (500 mg Kg(-1) i.p." . _:b420267328 . _:b420267329 . _:b420267285 . _:b420267330 . _:b420267331 . _:b420267340 . _:b420267341 . _:b420267284 . _:b420266995 . _:b420267342 . _:b420267343 . _:b420267336 . _:b420267337 . _:b420267287 . _:b420267338 . _:b420267282 . _:b420267339 . _:b420267331 . _:b420267316 . _:b420267317 . _:b420267286 . _:b420267318 . . _:b420267319 . _:b420267312 . _:b420267313 . _:b420267281 . _:b420267314 . _:b420267315 . _:b420267324 . _:b420267325 . _:b420267280 . _:b420267326 . _:b420267227 . _:b420267327 . _:b420267320 . _:b420267366 . . _:b420267321 . _:b420267283 . _:b420267100 . _:b420267322 . _:b420267263 . . _:b420267323 . . _:b420267300 . _:b420267301 . _:b420267282 . . _:b420267302 . _:b420267303 . _:b420267296 . _:b420267297 . _:b420267293 . _:b420267298 . _:b6567529 . _:b420267299 . _:b420267058 . _:b420267308 . . _:b420267292 . _:b420267270 . _:b420267309 . _:b420267310 . _:b420267311 . _:b420267304 . _:b420267305 . _:b420267295 . _:b420267306 . _:b420267307 . _:b420267284 . _:b420267285 . _:b420267377 . _:b420267294 . _:b420267286 . _:b420267311 . _:b420267287 . _:b420267222 . _:b420267280 . _:b420267281 . _:b420267289 . _:b420267282 . _:b420267283 . _:b420267292 . _:b420267293 . _:b420267288 . _:b420267294 . _:b420267295 . _:b420267315 . _:b420267288 . _:b420267038 . _:b420267291 . _:b420267289 . . _:b420267290 . . _:b420267291 . _:b420267268 . _:b420267269 . _:b420267290 . _:b420267270 . _:b420267271 . _:b420267264 . _:b420267265 . _:b420267336 . _:b420267301 . . _:b420267266 . . _:b420267267 . _:b420267363 . _:b420267310 . _:b420267276 . _:b420267277 . _:b420267300 . _:b420267278 . _:b420267279 . _:b420267146 . _:b420267272 . _:b420267273 . _:b420267303 . _:b420267027 . _:b420267006 . _:b420267274 . _:b420267275 . _:b420267362 . _:b420267302 . _:b420267297 . . _:b420267296 . . _:b420267299 . _:b420266952 . . _:b420267298 . . _:b420267309 . . _:b420267093 . . . _:b6567547 . _:b420267308 . _:b420267311 . _:b420267310 . . _:b420267341 . _:b420267077 . _:b420267135 . _:b420267305 . _:b420267304 . _:b6567552 "activity. The incubation of astrocytes with curcumin at a concentration that promoted hemoxygenase activity resulted in an early increase in reduced glutathione, followed by a significant elevation in oxidized glutathione content.[>>23<<\u201325] Glutathione is an important water-phase antioxidant and essential cofactor for antioxidant enzymes protecting the mitochondria against endogenous oxygen radicals." . _:b420266951 . . . _:b420267307 . . . _:b420267306 . _:b420267359 . _:b420267102 . . _:b420267317 . _:b6567530 "conclusion" . _:b420267207 . _:b420267316 . _:b420267300 . . _:b420267319 . _:b420267364 . _:b6567564 "[37] Researchers believe that by inhibiting cholesterol formation and decreasing serum peroxides, curcumin might exert beneficial effects on AD.[>>38<<" . _:b420267318 . . _:b420267313 . _:b6567568 "Co-supplementation with 20 mg of piperine (extracted from black pepper) significantly increase the bioavailablity of curcumin by 2000%.[>>43<<" . . _:b420267312 . _:b420267044 . . _:b420267315 . . _:b420267195 . _:b420267314 . _:b420267325 . _:b420267112 . _:b420267014 . _:b420267324 . _:b420267327 . _:b420267326 . . _:b420267321 . _:b420267320 . _:b420267323 . _:b420267230 . _:b420267322 . . _:b420267333 . _:b420267332 . _:b420267335 . _:b420266973 . _:b420267167 . _:b420267023 . _:b420267124 . _:b420267125 . _:b420267334 . _:b420267126 . _:b420267127 . _:b420267120 . _:b420267073 . _:b420267121 . _:b420267329 . _:b420267122 . _:b420267330 . _:b420267123 . _:b420267132 . _:b420267133 . _:b420267328 . . _:b420267134 . _:b420266938 . _:b420267135 . _:b420267128 . _:b420267129 . _:b420267331 . _:b420267130 . . . _:b420267131 . _:b420267108 . _:b6567568 . _:b420267109 . _:b420267330 . _:b420267110 . . _:b420267215 . _:b420267111 . _:b420267104 . _:b420267305 . _:b420267105 . _:b420267341 . _:b420267106 . _:b420267107 . _:b420267116 . _:b6567550 . _:b6567524 . . _:b420267340 . _:b420267157 . _:b420267117 . . _:b420267118 . _:b420267119 . _:b420267112 . _:b6567525 . _:b420267113 . _:b6567555 . _:b420267343 . _:b420267114 . _:b420267053 . _:b420267136 . _:b420267115 . _:b420266969 . _:b6567526 . _:b420267092 . . _:b420266988 . _:b420267342 . _:b420267093 . _:b420267094 . _:b420267095 . _:b420267267 . _:b420267088 . _:b6567527 . _:b420267089 . _:b420267337 . _:b6567537 "effects of curcumin on macrophages" . _:b420267090 . _:b420267091 . . _:b420267100 . _:b420267101 . _:b420267336 . _:b420267102 . . _:b420267103 . _:b420267096 . _:b420267097 . _:b420267339 . . _:b420267098 . _:b420267099 . _:b420267076 . _:b420267077 . _:b420267338 . _:b420267078 . _:b420267291 . . _:b420267079 . _:b420267072 . _:b6567523 . _:b420267349 . _:b420267073 . . _:b420267074 . _:b420267075 . _:b420267084 . _:b420266986 . _:b420267348 . _:b420267085 . _:b6567532 . _:b420266941 . _:b420267086 . _:b420267087 . _:b420267372 . . _:b6567533 . _:b420267080 . . _:b420267351 . _:b420267279 . _:b420267081 . _:b420266940 . _:b420267082 . _:b420267083 . _:b420267060 . _:b6567534 . _:b420266978 . _:b420267350 . _:b420267061 . _:b420266943 . _:b420267062 . _:b420267063 . . _:b6567535 . _:b420267056 . _:b420267057 . _:b420267345 . _:b420266942 . _:b420267058 . _:b420267059 . _:b420267068 . _:b6567528 . _:b420267069 . _:b420267344 . _:b420266937 . _:b420267070 . _:b420267071 . _:b420267064 . _:b6567529 . _:b420267065 . _:b420267347 . _:b420266936 . _:b420267066 . _:b420267067 . _:b420267044 . _:b6567530 . _:b420267346 . _:b420267045 . _:b420266939 . _:b420267046 . _:b420267047 . _:b420267040 . _:b6567531 . _:b420267041 . _:b420267357 . . _:b420266938 . _:b420267042 . _:b420267002 . . _:b420267043 . _:b420267052 . _:b6567540 . _:b420267356 . _:b420267053 . _:b420266949 . _:b420267054 . _:b420267055 . _:b6567536 "The study found that those who occasionally ate curry (less than once a month) and often (more than once a month) performed better on a standard test (MMSE) of cognitive function than those who ate curry never or rarely.[>>10<<" . _:b420267048 . _:b6567541 . _:b420267187 . _:b420267049 . _:b420267359 . _:b420266948 . _:b420267050 . _:b420267051 . _:b420267261 . _:b420267028 . _:b6567542 . _:b420267255 . _:b420267029 . _:b420267358 . _:b420266951 . _:b420267030 . _:b420267031 . . _:b6567543 . _:b420267024 . _:b420267025 . _:b420267353 . _:b420266950 . _:b420267026 . _:b420267027 . _:b420267036 . _:b6567536 . _:b420267177 . _:b420267037 . _:b420267352 . _:b420266945 . "PMC0" . _:b420267038 . _:b420267039 . _:b420267032 . _:b6567537 . _:b420267358 . _:b420267355 . _:b420267033 . _:b420266944 . _:b420267034 . _:b420267035 . _:b420267012 . _:b6567538 . _:b420267013 . _:b420267354 . _:b420266947 . _:b420267014 . _:b420267015 . _:b420267008 . _:b6567539 . _:b420267009 . _:b420267365 . _:b420266946 . _:b420267295 . _:b420267010 . _:b420267011 . . _:b6567548 . _:b420267020 . _:b420267021 . _:b420267364 . _:b420266957 . _:b420267022 . . _:b420267023 . . _:b6567549 . _:b420267016 . _:b420267017 . _:b420267367 . _:b420267081 . _:b420266956 . _:b420267018 . . _:b420267019 . . _:b6567550 . _:b420267252 . _:b420267253 . _:b420267366 . _:b420266959 . _:b420267254 . _:b420267255 . _:b420267254 . _:b420267248 . _:b6567551 . _:b420267361 . _:b420267249 . _:b420266958 . _:b420267250 . _:b420267251 . _:b420267260 . _:b6567544 . _:b420267261 . _:b420267360 . _:b420267139 . _:b420266953 . _:b420267262 . _:b420267263 . . _:b420267153 . _:b420267256 . _:b6567545 . _:b420267363 . _:b420267320 . _:b420267257 . _:b420266952 . _:b420267258 . _:b420267259 . _:b420267236 . _:b6567552 . _:b6567546 . _:b420267237 . _:b420267362 . _:b420266955 . _:b420267238 . _:b6567551 "curcumin on haemoxygenase pathway" . _:b420267239 . . _:b6567547 . _:b420267232 . _:b420267233 . _:b420267373 . _:b420266954 . _:b420267234 . . _:b420267235 . _:b420267244 . _:b6567556 . _:b420267021 . _:b420267372 . _:b420267245 . _:b420266965 . _:b420267246 . _:b420267247 . _:b6567570 "Curcumin supplementation of 20-40 mg have been reported to increase gallbladder contractions in healthy people.[>>4445<<" . . _:b6567557 . . _:b420267240 . _:b420267241 . _:b420267375 . _:b420266964 . _:b420267344 . _:b420267242 . _:b420267243 . _:b420267220 . _:b6567558 . _:b420267374 . _:b420267221 . . _:b420267222 . _:b420266967 . . _:b420267223 . _:b420267216 . _:b6567559 . _:b420267217 . _:b420267369 . _:b420266966 . _:b420267292 . _:b420267218 . _:b420267219 . _:b420267228 . _:b6567552 . _:b420267229 . _:b420267368 . _:b420266961 . _:b420267230 . . _:b420267231 . . _:b420267224 . _:b6567553 . _:b420267371 . _:b420267225 . _:b420266960 . _:b420267226 . _:b420267227 . _:b420267204 . _:b6567554 . _:b420267205 . _:b420267370 . _:b420266963 . _:b420267206 . . . _:b420267147 . _:b420267207 . _:b420267063 . _:b420267200 . _:b6567555 . _:b6567523 _:b6567528 . _:b420267381 . _:b420267201 . _:b420266962 . _:b420267202 . _:b6567523 _:b6567529 . _:b420267203 . _:b420267212 . _:b6567564 . _:b420267213 . _:b420267380 . _:b420266973 . _:b420267214 . . _:b420267215 . . _:b420267208 . _:b6567565 . _:b420267209 . _:b420266972 . _:b420267210 . _:b420267211 . _:b420267188 . _:b6567566 . _:b6567523 _:b6567524 . _:b420267189 . _:b420266975 . _:b420267190 . _:b6567523 _:b6567525 . . _:b6567523 _:b6567526 . _:b420267191 . _:b6567523 _:b6567527 . _:b6567567 . _:b420267184 . _:b420267185 . _:b420267377 . _:b420266974 . _:b6567559 . _:b420267186 . _:b420267187 . _:b420267196 . _:b6567560 . . _:b420267376 . _:b420267197 . _:b420266969 . _:b420267235 . _:b420267198 . _:b420267199 . _:b420267192 . _:b6567561 . _:b420267193 . _:b420267379 . _:b420266968 . _:b420267194 . _:b420267195 . _:b420267172 . _:b6567562 . _:b420267378 . _:b420267173 . . _:b420266971 . _:b420267174 . _:b420267175 . _:b420267168 . _:b6567563 . _:b420267169 . _:b420266970 . _:b420267170 . _:b420267171 . _:b420267180 . _:b6567572 . _:b6567532 _:b6567536 . _:b420267181 . _:b420266981 . _:b420267182 . _:b420267183 . _:b6567530 _:b6567531 . _:b6567573 . _:b420267176 . _:b420267177 . _:b420266980 . _:b420267178 . _:b420267179 . . _:b6567574 . _:b420267156 . _:b420267157 . _:b420266983 . _:b420267158 . _:b420266968 . _:b6567565 . _:b420267159 . _:b420267152 . _:b6567575 . _:b420267250 . . _:b420267149 . _:b420267153 . _:b420266982 . _:b420267154 . . _:b420267155 . _:b420267164 . _:b6567568 . _:b6567548 "and inflammation.[19] A study conducted at Jawaharlal Nehru University (India) demonstrated that the administration of curcumin significantly reduced lipid peroxidation and lipofuscin accumulation that is normally increased with aging.[>>20<<] It also increased the activity of superoxide dismutase, sodium-potassium ATPase that normally decreased with aging." . _:b420267253 . _:b420267165 . _:b420266977 . _:b420267166 . . . _:b420267167 . _:b420267160 . _:b6567569 . . _:b420267161 . . _:b420267162 . _:b6567532 _:b6567533 . _:b420266976 . _:b6567532 _:b6567534 . _:b420267163 . _:b6567532 _:b6567535 . _:b6567570 . _:b420267140 . _:b420267141 . _:b420266979 . _:b420267142 . . _:b420267143 . _:b420267184 . _:b420267136 . _:b6567558 "metal chelation" . _:b420267137 . _:b6567571 . _:b420267138 . _:b6567540 _:b6567541 . _:b420266978 . _:b420267139 . _:b6567540 _:b6567542 . _:b420267148 . _:b6567540 _:b6567543 . _:b420267149 . _:b420267150 . _:b6567545 "curcumin as an anti-oxidant" . _:b420266989 . _:b420267151 . _:b420267144 . _:b420267145 . . _:b420267146 . _:b420267116 . _:b420266988 . _:b420267147 . _:b420267013 "3"^^ . _:b6567540 _:b6567544 . _:b420266991 . _:b420267012 "3"^^ . _:b420266990 . . _:b6567537 _:b6567538 . _:b420267015 "3"^^ . _:b6567576 . _:b420267275 . _:b6567537 _:b6567539 . _:b420267194 . _:b420266985 . _:b420267014 "3"^^ . _:b6567577 . _:b420267098 . . . _:b420266984 . . . _:b420267009 "3"^^ . _:b6567578 . _:b420266987 . _:b420266967 . _:b6567539 "Its inhibition of microglial proliferation and differentiation were studied and researched by the University of Southern California Los Angeles (UCLA). Researchers[>>12<<] using doses of 4, 5, 10, 15, 20 microM concentration of curcumin in C-6 rat glioma 2B-clone cells, a mixed colony of both neuroglial cells in a six- day trial, showed that curcumin dose dependently stops the proliferation of neuroglial" . _:b420267008 "3"^^ . . _:b420266986 . _:b420267011 "3"^^ . _:b420266997 . . _:b420267010 "3"^^ . _:b420267170 . _:b420267043 . _:b420266996 . _:b420267021 "3"^^ . _:b420267223 . . _:b420266999 . _:b420267226 . _:b420267020 "3"^^ . _:b420267143 . _:b420266998 . . . . _:b420267023 "3"^^ . _:b420266993 . _:b420267022 "3"^^ . . _:b420266992 . _:b6567545 _:b6567546 . _:b6567545 _:b6567547 . _:b420267017 "3"^^ . _:b6567545 _:b6567548 . _:b6567545 _:b6567549 . _:b420266995 . _:b6567545 _:b6567550 . _:b420267016 "3"^^ . _:b420266994 . _:b420267019 "3"^^ . . _:b420267005 . _:b420267018 "3"^^ . . . _:b420267128 . _:b420267004 . . _:b420267029 "3"^^ . _:b420267007 . _:b420267277 . _:b420267028 "3"^^ . _:b420267006 . _:b420267031 "3"^^ . _:b420267001 . _:b420267172 . . _:b420267030 "3"^^ . _:b6567551 _:b6567552 . _:b420267000 . _:b420267338 . _:b420267025 "3"^^ . _:b6567574 "Given to aged Tg2576 mice with advanced amyloid accumulation, curcumin reduced amyloid levels and plaque burden reduction in plaque burden (p > 0.0001)[>>46<<]These changes were statistically significant p value (p > 0.001)[26]RatThe middle-aged rats (n = 10) that were fed with various diets were evaluated for spatial memory deficits in a standard Morris water maze, showed that A_infused rats" . . _:b6567565 "Curcumin has poor bioavailability. Because curcumin readily conjugated in the intestine and liver to form curcumin glucuronides.[>>39<<] In a clinical trial conducted in Taiwan, serum curcumin concentrations peaked one to two hours after an oral dose." . _:b420267003 . _:b420267243 . _:b420267024 "3"^^ . . _:b420267002 . . . _:b420267027 "3"^^ . _:b420267288 . . _:b420266953 . _:b420267026 "3"^^ . _:b420267037 "3"^^ . _:b6567557 . _:b420266947 . _:b6567526 . _:b420267036 "3"^^ . . . _:b420267039 "3"^^ . _:b420267218 . _:b420267134 . . . _:b420267038 "3"^^ . . _:b420267178 . _:b420267033 "3"^^ . _:b420267083 . . . _:b420267309 . _:b420267032 "3"^^ . . _:b420267031 . . _:b420267035 "3"^^ . _:b420267034 "3"^^ . _:b420267107 . _:b420267365 . _:b420267097 . _:b420267242 . _:b420267045 "3"^^ . _:b420267032 . _:b420267044 "3"^^ . . _:b420267088 . _:b420267286 . _:b420267047 "3"^^ . . . _:b420267212 . _:b420267046 "3"^^ . . _:b420267041 "3"^^ . _:b420267048 . _:b420267040 "3"^^ . . . _:b420267043 "3"^^ . . _:b420267042 "3"^^ . . . _:b420267053 "3"^^ . _:b420267078 . _:b420267191 . _:b420267052 "3"^^ . . _:b420267294 . _:b420267055 "3"^^ . . _:b420267054 "3"^^ . _:b420267202 . . . _:b420267049 "3"^^ . . . _:b420267048 "3"^^ . _:b6567563 . _:b420267051 "3"^^ . _:b420267050 "3"^^ . _:b420267380 . _:b420267186 . _:b6567561 "It is suggested that curcumin suppresses inflammatory damage by preventing metal induction of NF-kappa.[>>3536<<" . _:b420267061 "3"^^ . . . _:b420267060 "3"^^ . _:b420267328 . _:b6567558 . _:b420267193 . _:b420267063 "3"^^ . _:b6567572 . _:b6567553 . _:b6567532 "epidemiological studies" . _:b420267062 "3"^^ . _:b420266984 . _:b6567544 "prostaglandins. The reduction of the release of ROS by stimulated neutrophils, inhibition of AP-1 and NF-Kappa B inhibit the activation of the pro-inflammatory cytokines TNF (tumor necrosis factor)-alpha and IL (interleukin)-1 beta.[>>1516<<] Overall, curcumin decreases the main chemical for inflammation and the transcription of inflammatory cytokines." . . _:b420267057 "3"^^ . _:b6567543 "prostaglandins. The reduction of the release of ROS by stimulated neutrophils, inhibition of AP-1 and NF-Kappa B inhibit the activation of the pro-inflammatory cytokines TNF (tumor necrosis factor)-alpha and IL (interleukin)-1 beta.[>>15<<16] Overall, curcumin decreases the main chemical for inflammation and the transcription of inflammatory cytokines." . _:b6567562 . _:b420267056 "3"^^ . . . _:b420267059 "3"^^ . _:b420267378 . _:b6567571 . _:b420267317 . _:b420267058 "3"^^ . _:b420267020 . . _:b420267069 "2"^^ . . _:b420267068 "3"^^ . _:b420266965 . _:b6567571 _:b6567576 . _:b6567571 _:b6567577 . _:b6567571 _:b6567578 . . _:b420267071 "2"^^ . . _:b420267070 "2"^^ . _:b6567543 . _:b420267065 "3"^^ . _:b6567571 _:b6567572 . _:b6567571 _:b6567573 . _:b6567571 _:b6567574 . . _:b6567571 _:b6567575 . _:b420267064 "3"^^ . _:b6567562 _:b6567564 . _:b6567562 _:b6567565 . . _:b6567562 _:b6567566 . _:b6567562 _:b6567567 . _:b420267067 "3"^^ . . _:b6567562 _:b6567563 . _:b420267066 "3"^^ . . . _:b420267077 "2"^^ . _:b420267076 "2"^^ . _:b420267103 . _:b420267079 "2"^^ . . _:b420267205 . _:b420267078 "2"^^ . . _:b420267073 "2"^^ . _:b420267084 . . _:b6567562 _:b6567568 . _:b6567562 _:b6567569 . _:b6567562 _:b6567570 . _:b420266966 . _:b420267072 "2"^^ . _:b6567553 _:b6567554 . _:b420267075 "2"^^ . _:b6567553 _:b6567555 . _:b6567553 _:b6567556 . _:b6567553 _:b6567557 . _:b6567566 . _:b420267234 . _:b420267074 "2"^^ . _:b420267085 "2"^^ . _:b420267209 . _:b420267121 . _:b420267084 "2"^^ . . _:b420267266 . _:b420267087 "2"^^ . _:b420267283 . _:b6567558 _:b6567560 . _:b6567558 _:b6567561 . _:b6567538 "Thus, curcumin may support the immune system to clear the amyloid protein.[>>11<<" . _:b420267086 "2"^^ . . _:b420267081 "2"^^ . _:b6567558 _:b6567559 . _:b6567561 . _:b420267080 "2"^^ . _:b420267124 . . _:b420267083 "2"^^ . _:b420267082 "2"^^ . _:b420267119 . _:b420266946 . _:b420267093 "2"^^ . _:b420267148 . _:b420267092 "2"^^ . _:b420267095 "2"^^ . _:b420267345 . . _:b420267208 . _:b420267094 "2"^^ . _:b420266941 . . . _:b420267089 "2"^^ . _:b420266971 . _:b420267094 . _:b420267088 "2"^^ . _:b420267376 . . _:b420267091 "2"^^ . _:b420267090 "2"^^ . _:b420267337 . _:b6567576 . _:b420267101 "2"^^ . _:b420267166 . _:b420267100 "2"^^ . _:b420267103 "2"^^ . . _:b420267179 . _:b6567523 . _:b6567532 . _:b420267102 "2"^^ . . _:b420267097 "2"^^ . . _:b420267228 . _:b6567530 . _:b6567524 . _:b6567540 . _:b420267096 "2"^^ . _:b420267099 "2"^^ . _:b420267200 . _:b6567537 . _:b420267256 . . _:b420267098 "2"^^ . . _:b6567536 . . _:b6567551 . . _:b420267109 "2"^^ . _:b420267273 . _:b6567545 . _:b420266990 . _:b420267108 "2"^^ . . _:b420266960 . _:b420267111 "2"^^ . _:b420267349 . . . _:b420267110 "2"^^ . . _:b420267108 . _:b420267105 "2"^^ . _:b420267003 . _:b6567554 . _:b420267219 . _:b420267005 . _:b420267104 "2"^^ . . _:b6567534 . _:b420267289 . _:b420267107 "2"^^ . . . _:b420267079 . _:b420267106 "2"^^ . _:b420267095 . _:b6567560 . _:b420267117 "2"^^ . . . _:b420266972 . _:b420267182 . _:b420267116 "2"^^ . _:b420267144 . . . _:b420267119 "2"^^ . _:b420267155 . _:b420267290 . . _:b420266944 . _:b420267118 "2"^^ . _:b420266956 . _:b420267016 . . _:b420267113 "2"^^ . _:b420267224 . . _:b420267306 . _:b420267112 "2"^^ . _:b420267025 . _:b420267196 . . _:b420267115 "2"^^ . _:b420267114 "2"^^ . _:b420267125 "2"^^ . . . _:b420267321 . _:b420267124 "2"^^ . _:b6567575 . _:b420267127 "2"^^ . _:b6567573 . _:b420267281 . . _:b420267126 "2"^^ . _:b420266948 . _:b420267121 "2"^^ . _:b6567531 "The recent review paper of John Ringman also supports some of the abovementioned properties of curcumin in AD;[>>50<<] however, large-scale human studies are required to identify the prophylactic and therapeutic effect of curcumin." . _:b420267120 "2"^^ . . _:b420267123 "2"^^ . _:b420267039 . . _:b420267122 "2"^^ . . _:b420267133 "2"^^ . . _:b6567572 "Epidemiological studies have shown that prevalence of AD is 4.4 lower amongst Indian Asians as compared to people of western origin.[>>9<<] D ementia incidence in western countries (P < 0.21) and East Asian countries were lower than that of Europe (P < 0.0004)." . _:b420266981 . _:b420267132 "2"^^ . _:b420267135 "2"^^ . _:b420267348 . _:b6567528 "It has been used extensively in Ayurveda (Indian system of Medicine) for centuries as a pain relieving, anti-inflammatory agent to relieve pain and inflammation in the skin and muscles. It has also proven to have anti-cancer properties.[>>45<<] Curcumin holds a high place in Ayurvedic medicine as a \u201Ccleanser of the body,\u201D and today, science is finding a growing list of diseased conditions that can be healed by the active ingredients of turmeric." . . _:b420267134 "2"^^ . . . _:b420267114 . _:b420267129 "2"^^ . . _:b420267035 . . _:b420267128 "2"^^ . _:b420267013 . _:b420267340 . _:b420267299 . _:b420267131 "2"^^ . _:b420267012 . _:b420267087 . _:b420267130 "2"^^ . _:b420267260 . _:b420267258 . _:b420266954 . _:b420267015 . _:b420267141 "2"^^ . _:b420266962 . _:b420267014 . _:b420267140 "2"^^ . . _:b420267009 . . _:b420267143 "2"^^ . _:b420267318 . _:b420267324 . _:b420267008 . . _:b420267142 "2"^^ . _:b420267132 . . _:b420267011 . _:b420267137 "2"^^ . _:b6567534 "Various studies and research[>>910<<] results indicate a lower incidence and prevalence of AD in India. The prevalence of AD among adults aged 70-79 years in India is 4.4 times less than that of adults aged 70-79 years in the United States." . . . _:b420267010 . _:b420267136 "2"^^ . _:b420267021 . . _:b420267139 "2"^^ . _:b420267020 . . _:b420267138 "2"^^ . _:b420267023 . _:b420267149 "2"^^ . _:b420267022 . . . . _:b420267148 "2"^^ . _:b420267017 . . _:b420267151 "2"^^ . _:b420267016 . _:b420267150 "2"^^ . _:b420267019 . _:b420267145 "2"^^ . _:b420267018 . _:b420267144 "2"^^ . _:b420267029 . . . _:b420267147 "2"^^ . . _:b6567577 "in the diet for 4 weeks reduced the oxidative damage in rats (n = 8/group) with mild fluid percussion brain injury. Curcumin supplementation counteracted the impairment in cognition caused by traumatic brain injury with (p < 0.05).[>>47<<]PlanariaCurcumin improved the memory curves in planaria with correlation coef." . . _:b420267028 . _:b420267146 "2"^^ . . _:b420267031 . _:b420267157 "2"^^ . . _:b420267030 . . _:b420267156 "2"^^ . _:b6567552 . _:b420267025 . . _:b420267159 "2"^^ . _:b420267024 . . _:b420267158 "2"^^ . _:b420267027 . _:b420267153 "2"^^ . . _:b6567541 "The chemotaxis of monocytes, which can occur in response to chemokines from activated microglia and astrocytes in the brain, can be decreased by curcumin.[>>13<<" . . _:b420267026 . . _:b420267131 . _:b420267152 "2"^^ . _:b420267037 . _:b6567571 "human" . _:b420267155 "2"^^ . _:b420267036 . _:b420267154 "2"^^ . . _:b420267326 . _:b420267039 . _:b420267070 . _:b420267165 "2"^^ . _:b420267038 . _:b420267164 "2"^^ . . _:b420267033 . . _:b420267167 "2"^^ . _:b420267029 . _:b420267032 . _:b420267166 "2"^^ . _:b420267035 . _:b420267161 "2"^^ . . _:b6567563 "High-fat diets and increased blood cholesterol are linked to increased amyloid plaques by the intracellular accumulation of cholestryl esters.[>>37<<] Researchers believe that by inhibiting cholesterol formation and decreasing serum peroxides, curcumin might exert beneficial effects on AD." . _:b420267034 . _:b420267160 "2"^^ . _:b420267045 . _:b420267163 "2"^^ . . _:b420267044 . . _:b420267162 "2"^^ . . _:b420267047 . _:b420267173 "2"^^ . _:b420267046 . _:b420267061 . _:b420267172 "2"^^ . . _:b420267117 . _:b420266955 . _:b420267041 . . _:b420267175 "2"^^ . _:b420267040 . _:b420267138 . . _:b420267174 "2"^^ . . _:b420267043 . _:b420267169 "2"^^ . _:b420267042 . _:b420267015 . _:b6567541 . _:b420267168 "2"^^ . _:b420267053 . _:b420267145 . _:b420267171 "2"^^ . . _:b420267052 . . _:b420267170 "2"^^ . _:b420267133 . _:b420267245 . _:b420267055 . . _:b420267091 . _:b420267181 "2"^^ . _:b420267198 . _:b420267054 . _:b420267180 "2"^^ . _:b420267050 . _:b420267049 . _:b420267183 "2"^^ . _:b420267048 . _:b420267182 "2"^^ . _:b420267274 . _:b420267051 . _:b420267352 . _:b420267177 "2"^^ . . _:b420267050 . . _:b420267176 "2"^^ . _:b420267248 . _:b420267061 . _:b420267173 . _:b420267179 "2"^^ . _:b420267325 . _:b420267280 . . _:b420267060 . _:b420267028 . _:b420267271 . _:b420267178 "2"^^ . _:b420267063 . _:b420267189 "2"^^ . _:b420267062 . _:b420267343 . . _:b420267188 "2"^^ . _:b6567542 "The chemotaxis of monocytes, which can occur in response to chemokines from activated microglia and astrocytes in the brain, can be decreased by curcumin.[>>1314<<" . _:b420267057 . _:b420267191 "2"^^ . _:b420267056 . _:b420266949 . _:b420267089 . _:b420267265 . _:b420267190 "2"^^ . _:b420267059 . _:b420267185 "2"^^ . _:b6567567 "GI upset, chest tightness, skin rashes, swollen skin are said to occur with high dose. A few cases of allergic contact dermatitis from curcumin have been reported.[>>41<<" . _:b420267076 . _:b420267066 . _:b420267090 . _:b420267058 . _:b420267125 . _:b420267184 "2"^^ . _:b420267069 . . _:b420267187 "2"^^ . . _:b420267068 . _:b6567576 "the presence and absence of curcumin (30 mg/kg) were compared. Lead-induced damage to neurons signi. cantly reduced (p < 0.001) when studied microscopically to determine the extent of lead-induced damage to the cells in the hippocampus.[>>34<<] (2) 500 ppm of Curcumin in the diet for 4 weeks reduced the oxidative damage in rats (n = 8/group) with mild fluid percussion brain injury." . _:b420267186 "2"^^ . _:b420267071 . _:b420267188 . . _:b420267197 "2"^^ . _:b420267214 . _:b420267070 . _:b420267004 . _:b420267196 "2"^^ . . _:b420267065 . . _:b420267199 "2"^^ . . _:b6567555 "curcumin destabilizes the fA-beta(1-40) and fA-beta(1-42) as well as their extension.[27] Curcumin-derived isoxazoles and pyrazoles bind to the amyloid beta peptide (Abeta) and inhibit amyloid precursor protein (APP) metabolism.[>>28<<] Curcumin given to APPswe/PS1dE9 mice for 7 days crosses the blood-brain barrier as demonstrated by muliti-photon microscopy and reduces the existing senile plaques." . _:b420267064 . . _:b420267198 "2"^^ . _:b420267055 . _:b420267067 . _:b420267193 "2"^^ . _:b420267012 . _:b420267066 . _:b420267137 . _:b420267192 "2"^^ . _:b420267077 . _:b420267085 . . _:b420267195 "2"^^ . _:b420267076 . _:b420267194 "2"^^ . _:b420267079 . _:b420267000 . _:b420267205 "2"^^ . _:b420267078 . . _:b420267204 "2"^^ . _:b420267073 . _:b420267169 . _:b420267207 "2"^^ . . _:b420267072 . . _:b420267206 "2"^^ . _:b420267075 . _:b420267201 "2"^^ . _:b420267176 . _:b420267192 . . _:b420267074 . _:b420267200 "2"^^ . _:b420267085 . _:b420267203 "2"^^ . _:b420267084 . _:b6567556 . . _:b420267033 . _:b420267202 "2"^^ . _:b420267087 . _:b6567553 "beta-amyloid plaques" . _:b420267213 "2"^^ . _:b420267086 . . _:b420267212 "2"^^ . _:b420267081 . . . _:b420267215 "2"^^ . _:b420267122 . _:b6567557 "[29] In another study, curcumin has been shown to increase the phagocytosis of amyloid-beta, effectively clearing them from the brains of patients with AD.[>>30<<" . _:b420267080 . _:b420267214 "2"^^ . . . _:b420267083 . . _:b420267209 "2"^^ . _:b420267171 . _:b420267082 . _:b420267127 . _:b420267208 "2"^^ . . _:b420267093 . _:b420267211 "2"^^ . _:b420267092 . _:b420267373 . _:b420267086 . _:b420267210 "2"^^ . _:b420266976 . _:b420267095 . . _:b420267221 "2"^^ . . _:b420267094 . _:b6567549 "In another study, curcumin has been shown to protect the cells from betaA (1-42) insult through antioxidant pathway.[>>21<<] Curcumin protects brain mitochondria against various oxidative stress." . . _:b420267220 "2"^^ . _:b420267089 . . _:b420267223 "2"^^ . . . _:b420267088 . _:b420267246 . _:b420267222 "2"^^ . . _:b420267091 . _:b420267217 "2"^^ . . _:b420267090 . _:b420267216 "2"^^ . _:b6567542 . _:b420267101 . _:b420267312 . _:b420267219 "2"^^ . _:b420267100 . _:b420267008 . _:b420267218 "2"^^ . _:b420267381 . _:b420267199 . _:b420267103 . _:b420267229 "2"^^ . _:b420267102 . _:b420267228 "2"^^ . _:b420267249 . _:b420267097 . _:b420267231 "2"^^ . _:b420267045 . _:b420267096 . _:b420267230 "2"^^ . _:b420267099 . _:b420267225 "2"^^ . _:b420267098 . _:b420267224 "2"^^ . _:b6567548 . _:b420267109 . _:b420267227 "2"^^ . _:b420267108 . _:b420267226 "2"^^ . _:b420267111 . _:b420267237 "2"^^ . _:b420267110 . . . _:b420267236 "2"^^ . _:b420267106 . _:b420267238 . _:b420267105 . _:b420266993 . _:b420267239 "2"^^ . _:b420267370 . _:b420267104 . _:b420267238 "2"^^ . _:b6567526 "surrounded by dystrophic neuritis, reactive astrocytes and activated microglia. There is an increased presence of monocytes/macrophages in the cerebral vessel wall and reactive or activated microglial cells in the adjacent parenchyma.[>>23<<] The main protein component of amyloid in AD is the 39-42 amino acid (beta) amyloid peptide (A-beta) [Figure 1]." . _:b420267107 . . _:b420267233 "2"^^ . _:b420267106 . . _:b420267232 "2"^^ . _:b420267099 . _:b420267117 . _:b6567538 . _:b420267235 "2"^^ . _:b420267116 . _:b420267234 "2"^^ . _:b420267017 . _:b420267119 . _:b420267042 . _:b420267245 "2"^^ . . _:b420266977 . _:b420267118 . . _:b420267244 "2"^^ . _:b420267113 . . _:b420267247 "2"^^ . _:b420267112 . _:b420267007 . _:b420267246 "2"^^ . _:b420267115 . _:b420267241 "2"^^ . _:b420267114 . _:b420267240 "2"^^ . _:b420267268 . . _:b420267287 . _:b420267101 . _:b420267125 . _:b420266983 . _:b420267302 . _:b420267243 "2"^^ . _:b420267124 . _:b420267242 "2"^^ . _:b420267127 . _:b420267062 . _:b420267253 "2"^^ . _:b420267126 . . _:b420267252 "2"^^ . . _:b420267121 . _:b420267142 . _:b420267161 . . _:b420267255 "2"^^ . _:b420267120 . _:b420267036 . _:b420267254 "2"^^ . _:b6567547 "Curcumin has powerful antioxidant and anti-inflammatory properties; according to the scientists, these properties believe help ease Alzheimer's symptoms caused by oxidation and inflammation.[>>19<<] A study conducted at Jawaharlal Nehru University (India) demonstrated that the administration of curcumin significantly reduced lipid peroxidation and lipofuscin accumulation that is normally increased with aging." . _:b420267123 . . _:b6567564 . _:b6567525 . _:b420267249 "2"^^ . _:b420267303 . . _:b420267122 . _:b420267333 . _:b420267248 "2"^^ . _:b420267133 . _:b420267351 . _:b420267251 "2"^^ . . _:b420267322 . . _:b420267132 . _:b420267074 . . _:b420267250 "2"^^ . _:b420267135 . _:b420267261 "2"^^ . _:b420267367 . _:b420267134 . . _:b420267260 "2"^^ . _:b420267129 . _:b420267368 . _:b420267263 "2"^^ . . _:b420267128 . _:b420267262 "2"^^ . _:b420267131 . _:b420267257 "2"^^ . _:b420267130 . _:b420267256 "2"^^ . _:b420267141 . _:b420267259 "2"^^ . _:b420267285 . _:b420267140 . _:b420267258 "2"^^ . _:b420267143 . . _:b420267269 "2"^^ . . . _:b420267142 . _:b420267268 "2"^^ . _:b420267137 . . _:b420267271 "2"^^ . . _:b420267136 . _:b420267270 "2"^^ . _:b420267139 . . _:b420267265 "2"^^ . _:b420267138 . _:b420267264 "2"^^ . _:b420267149 . _:b420267267 "2"^^ . _:b420267148 . _:b420267353 . . _:b420267266 "2"^^ . _:b420267151 . _:b420267252 . _:b420267277 "2"^^ . _:b420267150 . . _:b420267276 "2"^^ . . _:b420267145 . . _:b420267279 "2"^^ . . . _:b420267144 . _:b420267278 "2"^^ . . . _:b420267147 . _:b420267273 "2"^^ . _:b420267241 . _:b420267146 . _:b420267262 . _:b420267272 "2"^^ . _:b420267157 . . _:b420267275 "2"^^ . . _:b420267156 . _:b420267274 "2"^^ . _:b420267159 . _:b420266974 . _:b420267285 "2"^^ . . . _:b420267158 . _:b420267284 "2"^^ . _:b420267153 . _:b420267049 . . _:b420267287 "2"^^ . . _:b420267152 . . _:b420267286 "2"^^ . _:b420267155 . _:b420267347 . _:b420267159 . . _:b6567525 "surrounded by dystrophic neuritis, reactive astrocytes and activated microglia. There is an increased presence of monocytes/macrophages in the cerebral vessel wall and reactive or activated microglial cells in the adjacent parenchyma.[>>2<<3] The main protein component of amyloid in AD is the 39-42 amino acid (beta) amyloid peptide (A-beta) [Figure 1]." . _:b420267281 "2"^^ . _:b420267154 . _:b420267280 "2"^^ . _:b420267329 . _:b420267009 . _:b420267165 . _:b420267283 "2"^^ . _:b420266945 . _:b420266937 . _:b420267164 . _:b420267282 "2"^^ . _:b420267167 . _:b420267011 . _:b420267013 . _:b420267293 "2"^^ . _:b420267166 . _:b420267229 . _:b420267292 "2"^^ . _:b420267161 . . _:b420267295 "2"^^ . _:b6567533 "Various studies and research[>>9<<10] results indicate a lower incidence and prevalence of AD in India. The prevalence of AD among adults aged 70-79 years in India is 4.4 times less than that of adults aged 70-79 years in the United States." . _:b420267160 . . _:b420267294 "2"^^ . _:b420267247 . _:b420267163 . _:b6567573 "[9] D ementia incidence in western countries (P < 0.21) and East Asian countries were lower than that of Europe (P < 0.0004).[>>49<<" . _:b420267289 "2"^^ . . _:b420267162 . . _:b420267288 "2"^^ . _:b420267173 . . _:b420267291 "2"^^ . . _:b420267172 . . _:b420267290 "2"^^ . _:b420267175 . _:b420267301 "2"^^ . _:b420266996 . _:b420266997 . _:b420267174 . . _:b420267096 . _:b420266998 . . _:b420267300 "2"^^ . _:b420266999 . . _:b420266992 . . _:b420266993 . _:b420267169 . _:b420267104 . _:b420266994 . _:b420266995 . _:b420267303 "2"^^ . _:b420267004 . _:b420267005 . _:b420267168 . _:b420267006 . _:b420267007 . _:b420267302 "2"^^ . _:b420267000 . _:b420267001 . _:b420267171 . _:b420267152 . _:b420267002 . . _:b420267297 "2"^^ . _:b420267003 . _:b420266980 . _:b420266981 . _:b420267170 . _:b420266982 . _:b420266983 . _:b6567527 "It has been used extensively in Ayurveda (Indian system of Medicine) for centuries as a pain relieving, anti-inflammatory agent to relieve pain and inflammation in the skin and muscles. It has also proven to have anti-cancer properties.[>>4<<5] Curcumin holds a high place in Ayurvedic medicine as a \u201Ccleanser of the body,\u201D and today, science is finding a growing list of diseased conditions that can be healed by the active ingredients of turmeric." . _:b420267296 "2"^^ . _:b420266976 . . _:b420266977 . _:b420267181 . _:b420266978 . _:b420266979 . _:b420267299 "2"^^ . _:b420266988 . . _:b420266989 . _:b420267180 . _:b420266990 . _:b420267374 . . _:b420266991 . _:b420267298 "2"^^ . . _:b420266984 . _:b420266985 . _:b420267183 . _:b420266986 . . _:b420266987 . _:b420267309 "2"^^ . _:b420267069 . _:b420266964 . . _:b420266965 . _:b420267182 . _:b420266966 . _:b420266967 . _:b420267308 "2"^^ . _:b420266960 . _:b420266961 . _:b420267357 . _:b420267177 . _:b420266962 . _:b420267231 . _:b420266963 . _:b420267311 "2"^^ . . _:b420266972 . . _:b420266973 . _:b6567527 . _:b420267332 . _:b420267176 . _:b420266970 . _:b420266974 . _:b420267022 . _:b420266975 . . _:b420266975 . _:b420267310 "2"^^ . _:b420266968 . _:b420266969 . _:b420267179 . _:b420266970 . _:b6567577 . _:b6567546 . _:b420266971 . _:b420267305 "2"^^ . _:b420266948 . _:b420266949 . _:b420267178 . _:b420266950 . _:b420266951 . _:b420267304 "2"^^ . _:b420266944 . _:b420266945 . _:b420267189 . . _:b420266946 . _:b6567544 . _:b420267308 . _:b420266947 . _:b420267307 "2"^^ . _:b420266956 . _:b420266957 . _:b420267188 . _:b420266958 . _:b420266959 . _:b420267306 "2"^^ . _:b420266952 . _:b6567569 "Curcumin supplementation of 20-40 mg have been reported to increase gallbladder contractions in healthy people.[>>44<<" . _:b420266953 . _:b420267191 . _:b420266954 . _:b420266955 . _:b420267317 "2"^^ . _:b420266963 . . _:b420267190 . _:b420267307 . _:b420267110 . _:b420267316 "2"^^ . _:b420267185 . _:b420267244 . _:b420267319 "2"^^ . _:b420266940 . _:b420266941 . _:b420267184 . _:b420266942 . . _:b420266943 . _:b420267318 "2"^^ . _:b420266936 . . _:b420266937 . _:b420267187 . _:b420266938 . _:b420266939 . _:b420267313 "2"^^ . _:b420267186 . _:b420267312 "2"^^ . _:b420267059 . _:b420267197 . _:b420267026 . . . _:b420267315 "2"^^ . _:b420267196 . _:b420267314 "2"^^ . . _:b420267199 . _:b420267325 "2"^^ . _:b420267060 . _:b420267198 . _:b420267324 "2"^^ . _:b420266980 . _:b420267193 . . _:b420267327 "2"^^ . . _:b420267192 . . _:b420267326 "2"^^ . . _:b420267195 . _:b420267051 . _:b420267321 "2"^^ . _:b420267194 . _:b420267320 "2"^^ . . _:b420267205 . _:b6567578 . _:b420267323 "2"^^ . . _:b420267204 . . _:b420267322 "2"^^ . _:b420267065 . . _:b420267207 . _:b420267333 "2"^^ . _:b420267206 . _:b420267259 . _:b420267332 "2"^^ . . _:b420267201 . _:b420267335 "2"^^ . . . _:b420267200 . _:b420267334 "2"^^ . _:b420267203 . . _:b420267329 "2"^^ . . _:b420267202 . _:b420267328 "2"^^ . _:b6567556 "(Abeta) and inhibit amyloid precursor protein (APP) metabolism.[28] Curcumin given to APPswe/PS1dE9 mice for 7 days crosses the blood-brain barrier as demonstrated by muliti-photon microscopy and reduces the existing senile plaques.[>>29<<] In another study, curcumin has been shown to increase the phagocytosis of amyloid-beta, effectively clearing them from the brains of patients with AD." . . _:b420267213 . . _:b420267331 "2"^^ . _:b420267154 . _:b420267212 . _:b420267330 "2"^^ . _:b420267346 . . _:b420267215 . _:b420267341 "2"^^ . _:b420267214 . _:b420267340 "2"^^ . _:b420267209 . . _:b420267123 . _:b420267343 "2"^^ . _:b6567569 . _:b420267208 . _:b420267342 "2"^^ . _:b6567562 "cholesterol lowering effect" . _:b420267211 . _:b420267337 "2"^^ . _:b420267239 . . _:b420267210 . _:b420267030 . _:b420267316 . _:b420267336 "2"^^ . _:b420267189 . _:b420267221 . _:b420267339 "2"^^ . . . _:b420267220 . _:b420267338 "2"^^ . _:b420267223 . . _:b420267349 "2"^^ . _:b420266994 . _:b420267222 . _:b420267348 "2"^^ . _:b420267217 . _:b420266942 "8"^^ . . _:b420267351 "2"^^ . _:b420267216 . _:b420266943 "8"^^ . _:b420266937 "17"^^ . _:b420267350 "2"^^ . _:b420266941 "10"^^ . _:b420266938 "14"^^ . . _:b420267219 . _:b420266936 "25"^^ . _:b420267345 "2"^^ . _:b420266940 "10"^^ . . _:b420267218 . _:b420267344 "2"^^ . . . _:b420267229 . _:b420267160 . _:b420267151 . "10.4103%2F0972-2327.40220" . _:b420266939 "12"^^ . _:b420267347 "2"^^ . . _:b420267228 . _:b420267346 "2"^^ . _:b420267231 . _:b420267357 "2"^^ . _:b420267230 . _:b6567570 . _:b420267356 "2"^^ . _:b420266950 "6"^^ . _:b420267126 . _:b420267129 . _:b420267225 . _:b420267359 "2"^^ . _:b420266951 "6"^^ . _:b420266961 . _:b420267224 . _:b420267358 "2"^^ . _:b6567560 "by these metals. The intraperitoneal injection of lead acetate in rats in the presence of curcumin was studied microscopically. The results show lead-induced damage to neurons was significantly reduced in rats injected with curcumin.[>>34<<] A study at Chinese University of Hong Kong showed that by using spectrophotometry, the curcumin effectively binds to copper, zinc and iron." . . _:b420267227 . . _:b420266948 "7"^^ . _:b420267113 . _:b420267353 "2"^^ . _:b420267217 . _:b420266949 "6"^^ . _:b420267226 . . _:b420267352 "2"^^ . _:b420267047 . . _:b420266946 "7"^^ . _:b420267237 . _:b420267355 "2"^^ . _:b420266947 "7"^^ . _:b420267236 . _:b420267046 . _:b420267354 "2"^^ . . _:b420266944 "7"^^ . _:b420267239 . . _:b420267365 "2"^^ . _:b420266945 "7"^^ . _:b420267238 . _:b420267150 . _:b420267364 "2"^^ . _:b420267185 . _:b420267233 . _:b420266942 . . _:b420267367 "2"^^ . _:b420266957 "5"^^ . _:b420267276 . _:b420267232 . . _:b420267366 "2"^^ . . _:b420266956 "6"^^ . _:b420267235 . _:b420267355 . _:b420266959 "5"^^ . _:b420267361 "2"^^ . . _:b420267234 . _:b420266958 "5"^^ . _:b420267360 "2"^^ . _:b420266954 "6"^^ . _:b420267068 . _:b420267245 . _:b420267225 . _:b420267363 "2"^^ . _:b420266955 "6"^^ . . _:b420267244 . _:b420267037 . _:b420267362 "2"^^ . _:b420266952 "6"^^ . _:b420267247 . _:b420267373 "2"^^ . _:b420266953 "6"^^ . _:b420267246 . _:b420267372 "2"^^ . _:b420267241 . . _:b420266965 "5"^^ . _:b420267375 "2"^^ . . _:b420267278 . . _:b420267369 . _:b420267240 . . . _:b420266964 "5"^^ . _:b420267374 "2"^^ . _:b420267041 . _:b420267140 . _:b420267243 . . _:b420266967 "5"^^ . _:b420267369 "2"^^ . _:b420267356 . _:b420267242 . _:b420266966 "5"^^ . _:b420267368 "2"^^ . . _:b420267175 . _:b420267253 . _:b420266961 "5"^^ . _:b420267371 "2"^^ . _:b420267252 . _:b6567574 . _:b420266960 "5"^^ . _:b420267370 "2"^^ . _:b420267040 . _:b420267255 . _:b420266963 "5"^^ . _:b420267381 "2"^^ . _:b420266957 . _:b420267254 . _:b420266962 "5"^^ . _:b420267380 "2"^^ . . _:b420267249 . _:b420267257 . _:b420266973 "5"^^ . . _:b420267248 . _:b420266972 "5"^^ . _:b420267251 . _:b420266975 "4"^^ . _:b420267377 "2"^^ . _:b420267250 . _:b420266974 "4"^^ . _:b420267376 "2"^^ . . _:b420267261 . _:b420266969 "5"^^ . _:b420267379 "2"^^ . . _:b420267260 . _:b420267206 . _:b420266968 "5"^^ . _:b420267378 "2"^^ . . _:b420267263 . _:b420267342 . _:b420266971 "5"^^ . . _:b420267262 . _:b420266970 "5"^^ . _:b420267301 . . _:b420267257 . . _:b420266981 "4"^^ . _:b420267204 . . . . _:b420267256 . _:b420266980 "4"^^ . . _:b420267259 . _:b420266983 "4"^^ . _:b420267164 . _:b420267258 . . _:b420266982 "4"^^ . _:b420266999 . _:b420266977 "4"^^ . . _:b420266976 "4"^^ . _:b420267130 . _:b420266940 . _:b420266996 . _:b420267180 . . . . . _:b420266979 "4"^^ . . . _:b420266959 . . . _:b420266978 "4"^^ . . _:b420266989 "4"^^ . . _:b420266988 "4"^^ . _:b420266991 "4"^^ . _:b420266950 . . _:b6567566 "glucuronides.[39] In a clinical trial conducted in Taiwan, serum curcumin concentrations peaked one to two hours after an oral dose. Peak serum concentrations were 0.5, 0.6 and 1.8 micromoles/L at doses of 4, 6 and 8 g/day respectively.[>>40<<] It is also measured in urine at a dose of 3.6 g/day. Absorption is poor following ingestion in mice and rats." . _:b420267240 . _:b6567539 . . _:b420266990 "4"^^ . _:b420267360 . . _:b420266985 "4"^^ . _:b420267109 . _:b420267296 . _:b6567531 . _:b420266984 "4"^^ . _:b420267174 . _:b420267141 . _:b420266987 "4"^^ . . _:b420266986 "4"^^ . _:b6567550 "(a product of the reaction of nitric oxide with superoxide) a potent and versatile oxidant that can attack a wide range of cells in vitro by direct detoxification and in vivo by the elevation of total cellular glutathione levels.[>>22<<" . _:b420267269 . _:b420267190 . _:b420266997 "4"^^ . . _:b420266996 "4"^^ . . _:b420267105 . _:b420266999 "4"^^ . . _:b420267010 . . _:b420266998 "4"^^ . . . _:b420266993 "4"^^ . _:b6567540 "curcumin as an anti inflammatory in alzheimer's" . . _:b420267067 . _:b420266992 "4"^^ . . _:b420266995 "4"^^ . . _:b420266994 "4"^^ . . _:b420267005 "3"^^ . _:b420267004 "3"^^ . . _:b420267007 "3"^^ . . _:b420267334 . _:b420267006 "3"^^ . _:b420267120 . _:b420267001 "3"^^ . . _:b420267000 "3"^^ . . _:b6567552 . . _:b420266985 . _:b420267003 "3"^^ . _:b420267165 . _:b420267002 "3"^^ . _:b420267354 . . _:b420267272 . _:b420267251 . _:b420267323 . . _:b420266998 . . _:b420267064 . _:b420267183 . _:b420267327 . . . . _:b420267314 . _:b420267284 . _:b6567523 "introduction" . . . _:b420267237 . _:b420266982 . . . _:b420267361 . _:b420267335 . _:b420267163 . _:b420267211 . . . . . . . . _:b420267019 . . . . _:b420266964 . _:b420267018 . _:b6567535 . . . . _:b420266997 . . _:b6567533 . . . . . . _:b420267168 . . . . _:b420267082 . _:b420266991 . _:b420267071 . _:b420266992 . _:b6567575 "Given to aged Tg2576 mice with advanced amyloid accumulation, curcumin reduced amyloid levels and plaque burden reduction in plaque burden (p > 0.0001)[46]These changes were statistically significant p value (p > 0.001)[>>26<<]RatThe middle-aged rats (n = 10) that were fed with various diets were evaluated for spatial memory deficits in a standard Morris water maze, showed that A_infused rats fed with curcumin (500 ppm) showed reduced path length and latency in" . . _:b420267379 . _:b420267210 . _:b6567535 "Various studies and research[910] results indicate a lower incidence and prevalence of AD in India. The prevalence of AD among adults aged 70-79 years in India is 4.4 times less than that of adults aged 70-79 years in the United States.[>>9<<] Researchers investigated the association between the curry consumption and cognitive level in 1010 Asians between 60 and 93 years of age." . . _:b420267339 . . _:b420267111 . _:b420267054 . _:b420266943 . _:b420267056 . _:b420267156 . . . _:b420267080 . . _:b420266979 . . . _:b420267201 . . _:b420267118 . . _:b6567528 . . . _:b420266989 . _:b420267181 . _:b6567567 . _:b6567549 . _:b420267297 . . . _:b420266958 . _:b6567554 "so-called \u201Cplaque burden\u201D that these beta-amyloid have on the brains of AD mice. Surprisingly low doses of curcumin given over longer period were actually more effective than high doses in combating the neurodegenerative process of AD.[>>26<<] At higher concentration, curcumin binds to amyloid beta and blocks its self assembly." . . _:b420267221 . . _:b420267115 . _:b420267162 . _:b420267236 . . _:b420267203 . _:b420267293 . . .