_:b433398648 . _:b433397917 . . _:b433398649 . _:b433398650 . _:b433398651 . _:b433398417 . _:b433398644 . _:b433398400 . . _:b433398645 . _:b433398646 . _:b433398647 . _:b433398416 . _:b433398640 . _:b433398641 . _:b433398642 . _:b433398643 . _:b433398419 . _:b433398604 . _:b433398605 . _:b433398606 . _:b433397461 . _:b433398607 . _:b433398418 . _:b433398600 . _:b433398601 . _:b433398602 . _:b433398603 . _:b433398429 . _:b433398596 . _:b433398597 . _:b433398598 . _:b433398599 . _:b433398428 . _:b433398592 . _:b433398593 . _:b433398594 . _:b433398595 . _:b433398431 . _:b433398620 . _:b433398621 . _:b433398622 . _:b433398623 . _:b433398430 . _:b433398616 . . _:b433398617 . _:b433398618 . _:b433398619 . _:b433398425 . _:b433398612 . . _:b433399527 . _:b433398613 . _:b433398614 . _:b433398615 . _:b433398424 . _:b433398608 . _:b433398609 . _:b433398610 . _:b433398611 . _:b433398427 . _:b433398572 . _:b433399295 . _:b433398573 . _:b433398574 . _:b433398575 . _:b433398426 . _:b433398568 . _:b433398132 . _:b433398569 . _:b433397389 . _:b433398570 . _:b433398571 . _:b433398437 . . . _:b433398564 . _:b433398565 . _:b433398566 . . _:b433398436 . _:b433398567 . _:b433398560 . _:b433398561 . _:b433398562 . _:b433398563 . _:b433398439 . _:b433398588 . _:b433398589 . _:b433398590 . _:b433398591 . _:b433398438 . _:b433398584 . . _:b433398585 . _:b433398586 . _:b433399319 . _:b433398587 . _:b433398433 . _:b433398580 . _:b433398581 . _:b433398582 . _:b433398583 . _:b433398432 . _:b433398576 . _:b433398577 . _:b433398578 . _:b433398579 . _:b433398435 . _:b433398540 . _:b433398541 . _:b433398033 . _:b433398542 . _:b433398278 . _:b433398543 . _:b433398434 . _:b433398536 . _:b433398537 . _:b433398538 . _:b433398539 . _:b433398445 . _:b433398532 . _:b433398533 . _:b433398965 . _:b433398534 . _:b433399449 . _:b433398535 . _:b433398444 . _:b433398543 . _:b433398343 . _:b433398528 . _:b433398529 . _:b433398530 . _:b433398531 . _:b433398447 . _:b433398556 . _:b433398557 . _:b433398558 . _:b433398559 . _:b433398446 . _:b433398552 . . _:b433398553 . . _:b433398554 . _:b433398555 . _:b433398441 . _:b433398548 . _:b433398549 . _:b433398550 . _:b433398551 . _:b433398440 . _:b433398544 . _:b433398545 . _:b433398546 . _:b433398547 . _:b433398443 . _:b433398764 . _:b433398765 . _:b433398255 . _:b433398766 . _:b433398429 . _:b433399139 . _:b433398767 . _:b433398442 . _:b433397182 . _:b433398760 . _:b433398761 . _:b433398762 . _:b433398763 . _:b433398453 . _:b433398756 . _:b433398757 . _:b433398758 . . _:b433398759 . _:b433398452 . _:b433398752 . _:b433398753 . _:b433398754 . _:b433398755 . _:b433398455 . _:b433398780 . _:b433399345 . _:b433398781 . . _:b433398782 . _:b433398783 . . _:b433398454 . _:b433398776 . _:b433398777 . _:b433398778 . _:b433398779 . _:b433398449 . _:b433398772 . _:b433398773 . . _:b433398774 . _:b433398775 . _:b433398448 . _:b433399409 . _:b433398768 . _:b433398769 . _:b433398770 . _:b433398771 . . _:b433398451 . . _:b433398732 . _:b433398733 . . _:b433398734 . _:b433398735 . _:b433398450 . _:b433398728 . _:b433398729 . _:b433398730 . . _:b433398731 . _:b433398461 . _:b433398724 . . _:b433398725 . _:b433398726 . _:b433398727 . _:b433398460 . _:b433398173 . _:b433398164 . _:b433398720 . _:b433398721 . _:b433398722 . . _:b433398723 . _:b433398463 . _:b433398748 . _:b433398749 . . _:b433398750 . _:b433398751 . _:b433398462 . _:b433398744 . . _:b433398745 . _:b433398746 . _:b433398747 . _:b433398457 . _:b433398740 . _:b433398741 . _:b433398742 . . _:b433398743 . _:b433398456 . _:b433398736 . _:b433398737 . _:b433398738 . _:b433398739 . _:b433398459 . _:b433398700 . _:b433398701 . _:b433398702 . _:b433398703 . _:b433398458 . _:b433397246 . _:b433397905 . _:b433398696 . _:b433398697 . _:b433398168 . _:b433398698 . _:b433398699 . _:b433398469 . _:b433398692 . _:b433398693 . . _:b433398694 . _:b433399163 . _:b433398695 . _:b433398468 . _:b433398688 . _:b433398689 . _:b433398690 . _:b433398691 . _:b433398471 . _:b433398716 . _:b433398717 . _:b433398718 . _:b433398939 . _:b433398719 . _:b433398470 . _:b433398712 . _:b433398713 . _:b433398714 . _:b433398715 . _:b433398465 . _:b433398708 . _:b433398740 . _:b433398709 . _:b433398710 . _:b433398711 . _:b433398464 . _:b433398704 . _:b433398705 . _:b433398706 . _:b433398707 . _:b433398467 . _:b433398668 . _:b433398669 . _:b433398795 . _:b433398670 . _:b433398671 . _:b433398466 . _:b433398664 . _:b433398665 . _:b433398666 . _:b433398667 . _:b433398477 . _:b433398660 . _:b433398070 . _:b433398661 . _:b433398662 . _:b433398663 . _:b433398476 . _:b433398995 . _:b433398656 . _:b433398657 . _:b433398658 . _:b433397105 . _:b433398659 . _:b433398479 . _:b433398684 . _:b433398685 . _:b433398686 . _:b433398687 . _:b433398478 . _:b433398680 . _:b433398245 . _:b433398681 . _:b433398682 . _:b433398683 . _:b433398473 . _:b433398676 . _:b433398677 . _:b433398678 . . _:b433398679 . _:b433398472 . _:b433398672 . . _:b433398673 . _:b433398674 . _:b433398675 . _:b433399294 . _:b433398475 . _:b433398380 . _:b433398381 . _:b433398382 . _:b433398383 . _:b433398474 . . _:b433398376 . _:b433398377 . _:b433398378 . _:b433398379 . _:b433398485 . _:b433398372 . _:b433398373 . _:b433398548 . _:b433398374 . _:b433398375 . _:b433398484 . _:b433398368 . _:b433398369 . _:b433398035 . _:b433398370 . . _:b433398371 . _:b433398487 . _:b433398396 . _:b433398397 . _:b433398398 . _:b433398399 . _:b433398486 . _:b433398392 . _:b433398393 . _:b433398394 . _:b433398536 . _:b433398395 . _:b433398481 . _:b433398388 . _:b433398389 . _:b433398390 . _:b433398391 . _:b433398999 . _:b433398480 . _:b433398384 . _:b433398385 . _:b433398386 . . _:b433398055 . _:b433398387 . _:b433398483 . _:b433398846 . _:b433398348 . _:b433398349 . _:b433398350 . _:b433398351 . _:b433398482 . _:b433398344 . _:b433398554 . _:b433398734 . _:b433398345 . _:b433398346 . _:b433398347 . _:b433399242 . _:b433398493 . _:b433398340 . _:b433398341 . _:b7741815 "BDCA3 is also expressed by Lin+ non-DCs (MacDonald et al., >>2002<<; unpublished data), and therefore caution must be exercised when using it as a marker." . _:b433398342 . _:b433398343 . _:b433398492 . _:b433398336 . _:b433398337 . . _:b433398338 . _:b433398339 . _:b433398495 . _:b433398364 . _:b433398365 . _:b433398366 . . _:b433398367 . . _:b433398494 . _:b433398360 . _:b433398361 . _:b433398362 . _:b433398363 . _:b433398489 . _:b433398570 . _:b433398356 . _:b433398357 . _:b433398358 . _:b433398359 . _:b433398488 . . _:b433398352 . _:b433398353 . _:b433398354 . _:b433398355 . _:b433398491 . _:b433398316 . _:b433398317 . _:b433398318 . _:b433398319 . _:b433398490 . _:b433398312 . . _:b433398313 . _:b433398314 . _:b433398315 . _:b433398501 . _:b433398308 . _:b433397098 "119"^^ . _:b433398882 . _:b433397598 . _:b433398309 . _:b433398310 . _:b433398311 . _:b433398500 . _:b433398304 . _:b433398305 . _:b433398306 . _:b433398307 . _:b433398503 . _:b433398332 . _:b433398333 . _:b433398334 . _:b433398335 . _:b433398502 . _:b433398328 . _:b433398329 . _:b7741833 "However, Batf3-dependent CD11b\u2212 CD103+ Langerin+ DCs related to CD8\u03B1+ DCs have recently been identified in mouse peripheral tissues (Bedoui et al., >>2009<<; Ginhoux et al., 2009; Edelson et al., 2010; Henri et al., 2010)." . _:b433398977 . _:b433398330 . _:b433398331 . _:b433398497 . _:b433398324 . _:b433398325 . . _:b433398326 . _:b433398327 . _:b433398496 . _:b433398320 . _:b433398321 . _:b433397099 "104"^^ . _:b433398322 . _:b433398323 . _:b433398499 . _:b433398284 . _:b433398285 . _:b433398286 . _:b433398287 . _:b433398498 . . _:b433398280 . _:b433398281 . _:b433398282 . _:b433398335 . _:b433398283 . _:b433398509 . _:b433398276 . _:b433398277 . _:b433398278 . _:b433398279 . _:b433398508 . _:b433398272 . _:b433398273 . . _:b433398274 . _:b433398275 . _:b433398511 . _:b433398300 . _:b433398301 . . _:b433398302 . _:b433397241 . _:b433398303 . _:b433398510 . _:b433398296 . _:b433398297 . _:b433398298 . . . _:b433398299 . _:b433398505 . _:b433398292 . _:b433398293 . _:b433398294 . _:b433398295 . _:b433398504 . _:b433398288 . _:b433398289 . _:b433398290 . _:b433398291 . . _:b433398507 . _:b433398508 . _:b433398509 . _:b433398510 . _:b433398511 . _:b433398506 . . _:b433398504 . _:b433398505 . _:b433398506 . _:b433398507 . _:b433398517 . _:b433398500 . . _:b433398501 . _:b433398502 . _:b433398503 . _:b433398516 . _:b433398496 . _:b433398497 . _:b433398498 . _:b433398499 . _:b433398519 . _:b433398524 . _:b433398525 . _:b433397110 . _:b433398526 . _:b433398527 . _:b433398518 . _:b433398520 . _:b433398521 . _:b433398522 . _:b433398523 . _:b433398513 . _:b433398516 . _:b433398517 . _:b433398518 . _:b433398519 . _:b433398512 . . _:b433398302 . _:b433398512 . _:b433398513 . . _:b433398514 . _:b433398515 . _:b433398515 . _:b433398476 . _:b433399233 . _:b433398477 . _:b433398478 . _:b433398479 . _:b433397915 . _:b433398514 . _:b433398472 . . _:b433398473 . _:b7741825 . _:b433399098 . _:b433398474 . _:b433398886 . _:b433398525 . _:b433398475 . _:b433398468 . _:b433398469 . _:b433398470 . _:b433397632 . _:b433398524 . _:b433399317 . _:b433398471 . _:b433398464 . _:b433398465 . _:b433398466 . _:b433397101 . _:b433398467 . . _:b433398527 . _:b433398492 . _:b433398775 . _:b433398493 . . _:b433398494 . _:b433397100 . _:b433398495 . _:b433398526 . _:b433398488 . _:b433398489 . _:b433398490 . _:b433397103 . _:b433398491 . . _:b433398521 . _:b433398484 . _:b433398485 . _:b433398432 . _:b433398486 . _:b433397102 . _:b433398487 . _:b433398520 . . _:b433398480 . _:b433398481 . _:b433398482 . _:b433398483 . _:b433398523 . _:b433398444 . _:b433398445 . _:b433398446 . _:b433398447 . _:b433398522 . _:b433398440 . _:b433398441 . _:b433398442 . _:b433397099 . _:b433398443 . _:b433398021 . _:b433398895 . _:b433398436 . _:b433398437 . _:b433397116 "32"^^ . _:b433397372 . _:b433398438 . _:b433397098 . _:b433398439 . . _:b433398020 . _:b433398432 . _:b433399149 . _:b433397117 "31"^^ . _:b433398433 . _:b433398434 . _:b433397109 . _:b433398435 . _:b433398023 . _:b433398460 . _:b433397118 "31"^^ . _:b433398461 . _:b433397418 . _:b433397108 . _:b433398462 . _:b433398463 . _:b433398022 . _:b433398456 . _:b433397119 "31"^^ . _:b433398457 . _:b433398458 . _:b433397111 . _:b433398459 . _:b433397113 "34"^^ . _:b433398017 . _:b433398452 . _:b433398453 . _:b433398454 . _:b7741823 "not identical to mouse CD8\u03B1+ DCs in regard to TLR9 expression, and it will be important to determine whether this might limit the effectiveness of CpG DNA oligonucleotides currently being tested as adjuvants in humans (Daubenberger, >>2007<<). Nevertheless, the ability of DNGR-1+ BDCA3+ DCs to respond to TLR8 agonists suggests that RNA-based adjuvants would be useful alternatives for use in vaccination protocols aimed at targeting these cells in vivo." . _:b433397110 . _:b433398455 . _:b433398016 . _:b433398448 . _:b433398449 . _:b433397112 "36"^^ . _:b433398450 . . _:b433397105 . _:b433398451 . _:b433397115 "34"^^ . _:b433398019 . _:b433398412 . _:b433398413 . _:b433398414 . _:b433397104 . . _:b433398415 . _:b433397114 "34"^^ . _:b433398018 . . _:b433398408 . . _:b433398409 . _:b433398410 . _:b433397107 . _:b433398411 . _:b433398029 . _:b433398404 . _:b433398405 . _:b433397109 "36"^^ . _:b433398406 . _:b433397106 . _:b433398407 . _:b433397504 . _:b433398028 . _:b433398400 . _:b433398401 . _:b433398402 . _:b433397117 . _:b433397108 "37"^^ . _:b433398403 . _:b433398031 . _:b433398428 . _:b433398429 . _:b433397111 "36"^^ . _:b433398430 . _:b433397116 . . _:b433399155 . _:b433398030 . _:b433398431 . _:b433398424 . _:b433398425 . _:b433397110 "36"^^ . _:b433398426 . _:b433397119 . _:b433398427 . _:b433398025 . _:b433398420 . . _:b433397106 "39"^^ . _:b433398421 . _:b433398724 . _:b433397118 . _:b433398422 . _:b433398423 . _:b433397107 "38"^^ . _:b433398024 . _:b433398416 . _:b433398417 . _:b433398418 . _:b433397113 . _:b433398419 . _:b433398027 . _:b433399148 . _:b433399149 . . _:b433397112 . _:b433399150 . _:b433399151 . _:b433398026 . _:b433399144 . _:b433397104 "43"^^ . . _:b433397105 "40"^^ . _:b433399145 . _:b433399146 . _:b433397115 . _:b433399147 . _:b433397490 . . _:b433398037 . _:b433399140 . _:b433399141 . _:b433399142 . . _:b433397114 . _:b433399143 . _:b433398036 . _:b433399136 . . _:b433399137 . _:b433399138 . _:b433397125 . _:b433399139 . _:b433398039 . _:b433399164 . _:b433399165 . _:b433399166 . _:b433397124 . _:b433399167 . _:b433398038 . _:b433399160 . _:b433399161 . _:b433399162 . _:b433397127 . _:b433399163 . _:b433398033 . _:b433399156 . _:b7741781 "results" . _:b433399157 . _:b433397102 "56"^^ . _:b433399158 . _:b433397126 . . _:b433399159 . _:b433398032 . _:b433399152 . _:b433398346 . _:b433399153 . _:b433399154 . _:b433397121 . _:b433399155 . _:b433398035 . _:b433399116 . _:b433399117 . _:b433399118 . _:b433397120 . _:b433399119 . _:b433397103 "46"^^ . _:b433398034 . _:b433399112 . _:b433399113 . _:b433399114 . _:b433397123 . _:b433399115 . _:b433398045 . _:b433399108 . _:b433399109 . _:b433399110 . _:b433397122 . _:b433399111 . _:b433398044 . _:b433399381 . _:b433399104 . _:b433399105 . . _:b433399106 . _:b433397133 . _:b433399107 . _:b433398047 . _:b433399132 . _:b433399133 . _:b433399134 . . _:b433397132 . _:b433399135 . _:b433398046 . _:b433399128 . _:b433397101 "71"^^ . _:b433399129 . . _:b433399130 . _:b433397135 . _:b433399131 . _:b433398041 . _:b433399124 . _:b433399125 . _:b433399126 . _:b433397134 . _:b433399127 . _:b433398040 . _:b433399120 . _:b433399121 . _:b433397100 "84"^^ . . _:b433399122 . _:b433397129 . _:b433399123 . _:b433398043 . _:b433399084 . . _:b433399085 . _:b433399086 . _:b433397128 . _:b433399087 . _:b433398042 . _:b433399080 . _:b433399081 . _:b433399082 . _:b433397131 . _:b433399083 . _:b433398053 . _:b433399076 . _:b433397123 "27"^^ . _:b433399077 . _:b433399078 . _:b433397130 . _:b433399079 . _:b433398052 . _:b433399072 . _:b433399073 . _:b433399074 . _:b433397141 . _:b433397122 "29"^^ . _:b433399075 . _:b433398055 . _:b433399100 . _:b433399101 . . _:b433399102 . _:b433397140 . _:b433397121 "29"^^ . . _:b433399103 . _:b433398054 . _:b433399096 . _:b433399097 . _:b433399098 . _:b433397143 . _:b433397120 "29"^^ . _:b433397884 . _:b433399099 . _:b433398049 . _:b433399092 . _:b433399093 . _:b433399094 . _:b433397142 . . _:b433399095 . _:b433397126 "26"^^ . _:b433398048 . _:b433399088 . _:b433398165 . _:b433399089 . _:b433399090 . _:b433397137 . _:b433397127 "25"^^ . _:b433399091 . _:b433398051 . _:b433399052 . _:b433397125 "27"^^ . _:b433397872 . _:b433398230 . _:b433397906 . _:b433399053 . _:b433399054 . _:b433397136 . . _:b433399055 . _:b433398050 . _:b433399048 . _:b433399322 . _:b433397124 "27"^^ . _:b433399049 . _:b433399050 . _:b433397139 . . _:b433398061 . _:b433399051 . _:b433399044 . . _:b433399045 . _:b433399046 . _:b433397138 . _:b433397130 "25"^^ . _:b433399047 . _:b433398060 . _:b433399040 . _:b433399041 . _:b433399042 . _:b433397149 . _:b433397131 "25"^^ . _:b433399043 . _:b433398063 . _:b433399068 . _:b433399069 . . _:b433398651 . _:b433397148 . _:b433397128 "25"^^ . _:b433399070 . _:b433399071 . _:b433398062 . _:b433399064 . _:b433399065 . . _:b433399066 . . _:b433397151 . _:b433397129 "25"^^ . . _:b433399067 . _:b433398057 . . _:b433399060 . _:b433399061 . _:b433397134 "24"^^ . _:b433399062 . _:b433397150 . _:b433399063 . _:b433398056 . _:b433399056 . . _:b433397135 "23"^^ . _:b433399057 . _:b433399058 . . _:b433397145 . _:b433399059 . _:b433398059 . _:b433399276 . _:b433399277 . _:b433397132 "24"^^ . _:b433399278 . _:b433397144 . _:b433399279 . _:b433398058 . _:b433398969 . _:b433399272 . _:b433399273 . _:b433397133 "24"^^ . _:b433399274 . _:b433397147 . _:b433399275 . _:b433397138 "22"^^ . _:b433398069 . _:b433399268 . . . _:b433399269 . . _:b433399270 . _:b433397146 . _:b433399271 . _:b433397139 "22"^^ . _:b433398068 . _:b433399264 . _:b433399265 . _:b433399266 . _:b433397157 . _:b433399267 . _:b433398071 . _:b433399292 . _:b433397136 "23"^^ . _:b433399293 . _:b433399294 . _:b433397156 . _:b433399295 . . _:b433398070 . _:b433399288 . _:b433397137 "23"^^ . _:b433399289 . _:b433399290 . _:b433397159 . _:b433399291 . _:b433398065 . _:b433399284 . _:b433399285 . _:b433399286 . _:b433397158 . _:b433397141 "21"^^ . _:b433399287 . _:b433398064 . _:b433399280 . _:b433399281 . . _:b433399282 . _:b433398519 . _:b433397153 . _:b433397140 "21"^^ . _:b433399283 . _:b433398067 . _:b433399244 . _:b433399245 . _:b433399246 . _:b433397152 . _:b433397143 "21"^^ . _:b433399247 . _:b433398066 . _:b433397296 . _:b433399240 . _:b433399241 . _:b433399242 . _:b433397155 . _:b433397142 "21"^^ . _:b433399243 . _:b433398077 . _:b433399236 . _:b433399237 . _:b433397145 "20"^^ . _:b433399238 . _:b433397154 . _:b433399239 . _:b433398076 . _:b433399232 . _:b433399233 . _:b433399234 . _:b433397165 . _:b433397144 "21"^^ . _:b433399235 . _:b433398079 . . _:b433399260 . _:b433397531 . _:b433399261 . _:b433397147 "20"^^ . _:b433399262 . _:b433397164 . _:b433399263 . _:b433398078 . _:b433399256 . _:b433399257 . _:b433397146 "20"^^ . _:b433399258 . _:b433397167 . . _:b433399259 . _:b433398073 . _:b433399252 . _:b433399253 . _:b433397149 "20"^^ . _:b433399254 . _:b433397166 . _:b433399255 . _:b433398072 . _:b433399248 . . _:b433399249 . _:b433397148 "20"^^ . . _:b433399250 . _:b433397161 . _:b433399251 . _:b433398075 . _:b433399212 . _:b433397151 "19"^^ . _:b433399213 . _:b433399214 . _:b433397160 . _:b433399215 . _:b433398074 . _:b433399208 . _:b433397150 "19"^^ . _:b433399209 . _:b433399210 . _:b433397163 . _:b433398866 . _:b433399211 . _:b433397153 "18"^^ . _:b433398085 . . _:b433399204 . _:b433399205 . _:b433399206 . _:b433397162 . _:b433399207 . _:b433398084 . _:b433399200 . _:b433398510 . _:b433398453 . _:b433397152 "19"^^ . _:b433397522 . _:b433399201 . _:b433399202 . _:b433397173 . _:b433399203 . _:b433397155 "18"^^ . _:b433398087 . _:b433399228 . _:b433399229 . _:b433399230 . _:b7741809 . _:b433397172 . _:b433399231 . _:b433397154 "18"^^ . _:b433398086 . _:b433399224 . _:b433399225 . _:b433398818 . . _:b433399226 . _:b433397175 . _:b433399227 . _:b433397157 "18"^^ . _:b433398081 . _:b433399220 . _:b433397159 . _:b433399221 . _:b433399222 . _:b433397174 . _:b433399223 . _:b433397156 "18"^^ . _:b433398080 . _:b433399216 . _:b433399217 . _:b433399218 . _:b433397169 . _:b433399219 . _:b433398083 . _:b433399180 . _:b433399181 . _:b433399182 . _:b433397168 . _:b433397158 "17"^^ . _:b433399183 . _:b433398082 . _:b433399176 . _:b433399177 . _:b433399178 . _:b7741818 . _:b433397171 . _:b433397159 "17"^^ . . _:b433399179 . _:b433398093 . _:b433399172 . _:b433399173 . _:b433398730 . _:b433399174 . _:b433397170 . _:b433397160 "17"^^ . _:b433399175 . _:b433398092 . . _:b433399168 . . _:b433399169 . _:b433399170 . _:b433397181 . _:b433397161 "17"^^ . _:b433399171 . _:b433398095 . _:b433399196 . _:b433399197 . _:b433397162 "16"^^ . _:b433399198 . _:b433397180 . _:b433399199 . _:b433398125 . _:b433398094 . _:b433399192 . _:b433399193 . _:b433397163 "16"^^ . _:b433399194 . _:b433397183 . _:b433399195 . _:b433398089 . _:b433399188 . _:b433399189 . _:b433397164 "16"^^ . _:b433399190 . _:b433398490 . _:b433397182 . _:b433399191 . _:b433397322 . _:b433398088 . _:b433399184 . _:b433399185 . . _:b433397165 "16"^^ . _:b433399186 . _:b433397177 . _:b433399187 . _:b433398091 . _:b433398892 . _:b433398893 . _:b433397166 "16"^^ . _:b433398894 . _:b433397176 . _:b433398895 . _:b433398090 . _:b433398888 . _:b433398889 . _:b433397167 "16"^^ . _:b433398890 . _:b433397179 . _:b433398891 . _:b433398101 . _:b433398884 . _:b433398885 . _:b433397168 "16"^^ . _:b433398886 . _:b433397480 . _:b433397178 . _:b433398420 . _:b433398887 . _:b433398100 . _:b433398880 . _:b433398881 . _:b433397169 "16"^^ . _:b433398882 . _:b433397189 . _:b433398883 . _:b433398103 . _:b433398908 . _:b433398909 . _:b433397170 "16"^^ . _:b433398910 . _:b433397188 . . _:b433398102 . _:b433398911 . _:b433398904 . _:b433397171 "15"^^ . _:b433398905 . _:b433398906 . _:b433397191 . _:b433398907 . _:b433398097 . _:b433398900 . _:b433397172 "15"^^ . . _:b433398901 . . _:b433398902 . _:b433397190 . _:b433398903 . _:b433398096 . _:b433398896 . _:b433397173 "15"^^ . _:b433398897 . _:b433398898 . _:b433397185 . _:b433398899 . _:b433398099 . _:b433398860 . _:b433397174 "15"^^ . _:b433398861 . _:b433398862 . _:b433397184 . _:b433398863 . _:b433398098 . . _:b433398856 . _:b433397175 "15"^^ . _:b433398857 . _:b433398858 . _:b433397726 . _:b433397187 . _:b433398859 . _:b433398109 . _:b433398852 . _:b433397176 "15"^^ . _:b433398853 . _:b433398854 . _:b433397186 . _:b433398855 . _:b433398108 . _:b433398848 . _:b433397177 "15"^^ . _:b433398849 . _:b433397755 . _:b433398850 . _:b433399241 . _:b433397197 . _:b433398851 . _:b433398111 . _:b433398876 . _:b433397178 "15"^^ . _:b433398877 . _:b433398878 . _:b433397196 . . _:b433398879 . _:b433398110 . _:b433398872 . _:b433397179 "15"^^ . _:b433398873 . _:b433398874 . _:b433397199 . _:b433398875 . _:b433398105 . _:b433398868 . _:b433397180 "15"^^ . _:b433398869 . . _:b433398870 . _:b433397198 . _:b433398871 . _:b433398104 . _:b433398200 . _:b433398864 . _:b433397181 "15"^^ . _:b433398865 . _:b433398866 . _:b433397193 . _:b433398867 . _:b433398107 . _:b433398828 . _:b433397182 "15"^^ . _:b433398829 . _:b433398830 . _:b433397192 . _:b433398831 . . _:b433397183 "14"^^ . _:b433398106 . _:b433398824 . _:b433397807 . _:b433398825 . _:b433398826 . _:b433397195 . _:b433398827 . _:b433397184 "14"^^ . _:b433398117 . _:b433398820 . _:b433398821 . _:b433398822 . _:b433397194 . _:b433398823 . _:b433397185 "14"^^ . _:b433398116 . _:b433398816 . _:b433398817 . _:b433398818 . _:b433397205 . . _:b433398622 . _:b433398819 . _:b433397186 "14"^^ . _:b433398119 . _:b433398844 . _:b433398845 . _:b433398846 . _:b7741777 . _:b433397204 . . _:b433397187 "14"^^ . _:b433398118 . _:b433398847 . _:b433398034 . _:b433398840 . _:b433398841 . _:b433398842 . _:b433397207 . _:b433398843 . _:b433397188 "14"^^ . _:b433398113 . _:b433398836 . _:b433398837 . . _:b433398838 . _:b433397206 . _:b433398839 . _:b433397189 "14"^^ . _:b433398112 . _:b433398832 . _:b433397642 . _:b433398833 . _:b433398834 . _:b433397201 . _:b433398835 . _:b433397190 "14"^^ . _:b433398115 . _:b433398796 . _:b433398797 . _:b433398798 . _:b433397200 . _:b433398799 . _:b433397191 "14"^^ . _:b433398114 . _:b433398792 . _:b433398793 . _:b433398794 . _:b433399514 . _:b433397203 . _:b433398795 . _:b433397192 "14"^^ . _:b433398125 . _:b433398788 . _:b433398789 . _:b433398790 . _:b433397202 . _:b433397199 "13"^^ . _:b433398791 . _:b433398124 . _:b433398784 . _:b433398785 . _:b433398786 . _:b433397213 . _:b433397198 "13"^^ . _:b433398787 . _:b433398127 . . _:b433398812 . . _:b433398813 . _:b433398814 . _:b433397212 . _:b433397197 "13"^^ . _:b433397878 . _:b433398126 . _:b433398815 . _:b433398808 . _:b433398809 . _:b433398810 . _:b433397215 . _:b433397196 "13"^^ . _:b433398811 . _:b433398121 . _:b433398804 . _:b433398805 . _:b433398806 . . _:b433397214 . _:b433397195 "13"^^ . _:b433398569 . _:b433398807 . _:b433398120 . _:b433398800 . _:b433398801 . _:b433398802 . _:b433397209 . _:b433397194 "13"^^ . _:b433398803 . _:b433398123 . _:b433399020 . _:b433399021 . _:b433399022 . _:b433397208 . _:b433397193 "13"^^ . _:b433399023 . _:b433398122 . _:b433399016 . _:b433399017 . _:b433399018 . _:b433397211 . _:b433399019 . _:b433398133 . _:b433398433 . _:b433399012 . _:b433399013 . _:b433399014 . _:b433397210 . _:b433397207 "13"^^ . _:b433399015 . _:b433398132 . _:b433399008 . _:b433399009 . _:b433399010 . _:b433397221 . _:b433397206 "13"^^ . _:b433399011 . _:b433398135 . _:b433399036 . _:b433399533 . _:b433399037 . _:b433399038 . _:b433397220 . _:b433397205 "13"^^ . _:b433399039 . _:b433398134 . _:b433399032 . _:b433399033 . _:b433399034 . _:b433397223 . _:b433397204 "13"^^ . _:b433399035 . _:b433398129 . _:b433399028 . _:b433397481 . _:b433399029 . _:b433399030 . _:b433397222 . _:b433397203 "13"^^ . _:b433399031 . _:b433398128 . _:b433399024 . _:b433399025 . _:b433399026 . _:b433397217 . _:b433397202 "13"^^ . _:b433399027 . _:b433398131 . _:b433398988 . _:b433398989 . _:b433398990 . _:b433397216 . _:b433397201 "13"^^ . _:b433398991 . _:b433398130 . _:b433398984 . _:b433398985 . _:b433398986 . _:b433397219 . _:b433397200 "13"^^ . _:b433399412 . _:b433397880 . . _:b433398141 . _:b433398987 . _:b433398980 . _:b433398981 . _:b433397215 "12"^^ . _:b433398982 . _:b433397218 . _:b433398983 . _:b433398140 . _:b433398976 . _:b433398977 . _:b433397214 "12"^^ . _:b433398978 . _:b433397229 . _:b433398979 . _:b433398143 . _:b433399004 . _:b433399005 . _:b433397213 "12"^^ . . _:b433399006 . _:b433397228 . . _:b433399007 . _:b433398142 . _:b433399000 . _:b433397440 . _:b433399001 . _:b433397212 "12"^^ . . _:b433399002 . _:b433397231 . _:b433399003 . _:b433398137 . _:b433398996 . _:b433398997 . _:b433397211 "12"^^ . _:b433398998 . _:b433397230 . _:b433398254 . _:b433398999 . _:b433398136 . _:b433398992 . _:b433398993 . _:b433397210 "12"^^ . _:b433398994 . _:b433397225 . _:b433398995 . _:b433398139 . _:b433398956 . _:b433398957 . _:b433397209 "12"^^ . . _:b433398958 . _:b433397224 . _:b433398959 . _:b433398138 . _:b433398952 . _:b433398953 . _:b433397789 . _:b433397227 . _:b433397208 "13"^^ . _:b433398954 . _:b433398955 . _:b433398149 . . _:b433397223 "11"^^ . _:b433398948 . _:b433398949 . . _:b433398950 . _:b433397226 . _:b433398951 . _:b433398148 . . _:b433398944 . _:b433398945 . _:b433397222 "12"^^ . . _:b433398946 . _:b433397237 . . _:b433398947 . _:b433398151 . _:b433398972 . _:b433398973 . _:b433397221 "12"^^ . _:b433398974 . _:b433397236 . _:b433398975 . _:b433398150 . _:b433398968 . _:b433398969 . _:b433397220 "12"^^ . _:b433398970 . _:b433397239 . _:b433398971 . _:b433398145 . _:b433398964 . _:b433398965 . . _:b433397219 "12"^^ . _:b433398966 . _:b433397238 . _:b433398967 . _:b433398144 . _:b433398960 . _:b433397666 . _:b433397218 "12"^^ . _:b433398961 . _:b433398962 . _:b433397485 . _:b433398348 . _:b433397233 . _:b433398963 . _:b433398147 . _:b433398924 . _:b433398925 . _:b433397217 "12"^^ . _:b433398926 . _:b433397232 . . _:b433398927 . _:b433398146 . _:b433398920 . _:b433398921 . _:b433397216 "12"^^ . _:b433398922 . _:b433397235 . _:b433398923 . _:b433397751 . _:b433398157 . _:b433398916 . _:b433397231 "11"^^ . _:b433398917 . _:b433398918 . _:b433397234 . . _:b433398919 . _:b433398156 . _:b433398912 . _:b433397230 "11"^^ . _:b433398913 . _:b433398914 . _:b433397245 . _:b433398915 . _:b433398159 . _:b433398940 . _:b433397229 "11"^^ . _:b433398941 . _:b433398942 . _:b433397244 . _:b433398943 . . _:b433398158 . _:b433398936 . _:b433397228 "11"^^ . _:b433398937 . _:b433398938 . _:b433397247 . _:b433398939 . _:b433398153 . _:b433398932 . _:b433397227 "11"^^ . _:b433398933 . _:b433398934 . _:b433397246 . _:b433398935 . _:b433398152 . . _:b433397226 "11"^^ . _:b433398928 . _:b433398929 . _:b433398930 . _:b433397241 . _:b433397605 . _:b433398931 . _:b433398155 . _:b433397225 "11"^^ . _:b433397240 . _:b433398154 . . _:b433397224 "11"^^ . . _:b433397243 . _:b433398165 . . _:b433397239 "11"^^ . _:b433397242 . . _:b433398164 . _:b433397238 "11"^^ . _:b433398167 . _:b433397237 "11"^^ . _:b433398166 . . _:b433397236 "11"^^ . . _:b433399271 . _:b433398161 . _:b433397235 "11"^^ . _:b433398160 . . _:b433397234 "11"^^ . _:b433398177 . _:b433398163 . _:b433397233 "11"^^ . _:b433398162 . _:b433397232 "11"^^ . _:b433398173 . _:b433397247 "10"^^ . . _:b433398172 . _:b433397246 "10"^^ . _:b433397264 . . _:b433397245 "10"^^ . _:b433398175 . _:b433397324 . _:b433397104 . _:b433398174 . _:b433397244 "10"^^ . . . _:b433398169 . _:b433397243 "10"^^ . . _:b433398168 . _:b433397242 "10"^^ . _:b433398677 . _:b433398171 . _:b433397241 "10"^^ . _:b433398381 . _:b433397494 . _:b433398170 . _:b433397240 "11"^^ . _:b433398181 . _:b433398180 . _:b433399034 . _:b433398183 . . _:b433398182 . . _:b433398177 . _:b433398687 . _:b433398176 . _:b433398179 . _:b433398178 . _:b433398189 . _:b433398188 . _:b433398191 . . _:b433398190 . _:b433398135 . . _:b433398185 . _:b433397305 . _:b433398184 . . _:b433398187 . _:b433398537 . _:b433398186 . _:b433397980 . _:b433398197 . _:b433398196 . . _:b433398199 . . _:b433399442 . _:b433398198 . _:b433398193 . _:b433398206 . _:b433398192 . . _:b433398195 . . _:b433398194 . _:b433398205 . _:b433398136 . _:b433398590 . _:b433398111 . _:b433398204 . _:b433398207 . . _:b433398206 . _:b433397233 . _:b433398201 . _:b433398200 . _:b433398157 . _:b7741804 . _:b433398203 . _:b433398202 . _:b433398397 . _:b433398213 . . _:b433398212 . _:b433398215 . _:b433398214 . . _:b433398209 . _:b433397973 . _:b433398208 . _:b433397348 . _:b433398211 . _:b433398210 . _:b433398221 . _:b433398220 . _:b433398223 . _:b433399169 . _:b433398222 . . . _:b433398258 . _:b433398217 . _:b433398216 . . _:b433398219 . _:b433399404 . _:b433399405 . _:b433399406 . . _:b433398218 . _:b433399407 . _:b433399400 . _:b433399401 . _:b433399402 . _:b433399403 . _:b433398229 . _:b433399396 . . _:b433399397 . _:b433399398 . _:b433399399 . _:b433398228 . . _:b433399392 . _:b433399393 . _:b433399394 . _:b433399395 . _:b433398231 . _:b433399420 . _:b433399421 . . _:b433399422 . _:b433399423 . _:b433398230 . _:b433399416 . _:b433399417 . _:b433399418 . _:b433399419 . _:b433398225 . _:b433399412 . _:b433399413 . _:b433398291 . _:b433399414 . _:b433399415 . _:b433398224 . . _:b433399408 . _:b433399409 . _:b433399410 . _:b433399411 . _:b433398227 . _:b433399372 . _:b433399373 . . _:b433399374 . _:b433399375 . _:b433398226 . _:b433399368 . _:b433399369 . _:b433399370 . _:b433398153 . _:b433399371 . _:b433398237 . _:b433399364 . _:b433399365 . _:b433399366 . _:b433398189 . _:b433399367 . _:b433398236 . _:b433399360 . _:b433398871 . . _:b433399323 . _:b433399361 . _:b433399362 . _:b433399363 . _:b433398239 . _:b433399388 . . _:b433399389 . _:b433399390 . _:b433399391 . _:b433398238 . _:b433399384 . _:b433399385 . . _:b433399386 . _:b433399387 . _:b433398233 . _:b433399380 . _:b433399381 . _:b433399382 . _:b433399383 . _:b433398232 . _:b433399376 . . _:b433399377 . _:b433399378 . _:b433399379 . _:b433398235 . _:b433399340 . _:b433399341 . . _:b433399342 . . _:b433399343 . _:b433398234 . _:b433399336 . _:b433399337 . _:b433399338 . _:b433399339 . _:b433398245 . _:b433399332 . _:b433399333 . _:b433399334 . . _:b433399335 . _:b433398244 . _:b433399328 . _:b433399329 . _:b433399330 . _:b433399331 . _:b433398247 . . _:b433399356 . _:b433399357 . _:b433399358 . _:b433399359 . _:b433398246 . _:b433399352 . _:b433399353 . _:b433399354 . _:b433399355 . _:b433398241 . _:b433399348 . _:b433399349 . _:b433398139 . _:b433399350 . _:b433399351 . _:b433398240 . _:b433399344 . _:b433399345 . _:b433399346 . _:b433399347 . _:b433398243 . _:b433399308 . . _:b433399309 . _:b433399310 . _:b433399311 . _:b433398242 . _:b433399304 . _:b433399305 . _:b433399306 . _:b433399307 . _:b433398253 . _:b433399300 . _:b433399301 . _:b433399302 . _:b433399303 . _:b433398252 . _:b433399296 . _:b433399297 . _:b433399415 . . _:b433399298 . _:b433399299 . . _:b433398255 . _:b433399324 . _:b433399325 . . _:b433399326 . . _:b433397384 . _:b433399327 . _:b433398254 . _:b433399320 . _:b433399321 . _:b433398864 . _:b433399322 . _:b433399323 . _:b433398249 . _:b433397470 . _:b433399316 . _:b433399317 . _:b433399318 . _:b433397709 . _:b433398248 . _:b433399319 . _:b433399312 . _:b433399313 . _:b433399314 . _:b433399315 . _:b433398251 . _:b433399532 . . _:b433399533 . _:b433399534 . _:b433399535 . . _:b433398250 . _:b433399528 . _:b433399529 . _:b433399530 . _:b433399531 . _:b433398261 . _:b433399524 . _:b433399525 . _:b433399526 . _:b433399527 . _:b433398260 . _:b433399520 . _:b433399521 . _:b433399522 . _:b433399523 . _:b433398263 . _:b433399548 . _:b433398755 . _:b433399549 . . _:b433398262 . . _:b433397256 . _:b433399544 . _:b433399545 . _:b433399546 . _:b433399547 . _:b433398257 . _:b433399540 . _:b433399541 . _:b433399542 . _:b433399543 . _:b433398256 . _:b433399536 . _:b433399537 . . _:b433399538 . _:b433399539 . _:b433398259 . . _:b433399500 . _:b433399501 . _:b433399502 . _:b433399503 . _:b433398258 . _:b433399496 . _:b433399497 . _:b433399498 . _:b433397560 . _:b433398269 . _:b433399499 . _:b433399492 . _:b433399493 . . _:b433399494 . _:b433398910 . _:b433398268 . _:b433398580 . _:b433399495 . _:b433399488 . _:b433399489 . _:b433399490 . _:b433399491 . _:b433398271 . _:b433399516 . _:b433399517 . _:b433399518 . _:b433399519 . _:b433398270 . _:b433399512 . _:b433399513 . _:b433399514 . _:b433399515 . _:b433398265 . _:b433399508 . _:b433399509 . _:b433399510 . . _:b433398099 . _:b433398264 . _:b433399511 . _:b433399504 . _:b433399153 . _:b433399505 . _:b433399506 . _:b433399195 . _:b433397148 . _:b433399507 . _:b433398267 . _:b433399468 . _:b433399469 . _:b433399470 . . _:b433399471 . _:b433398266 . . _:b433398654 . _:b433399464 . _:b433399465 . . _:b433399466 . _:b433399467 . _:b433397844 . _:b433397765 . _:b433399460 . _:b433399461 . _:b433399462 . _:b433399288 . _:b433397764 . _:b433399463 . . _:b433399456 . _:b433399457 . _:b433399458 . _:b433399459 . _:b433397767 . _:b433399484 . _:b433399485 . _:b433399486 . _:b433399487 . _:b433397766 . _:b433399480 . _:b433399481 . _:b433399482 . _:b433399483 . _:b433397761 . _:b433399476 . _:b433399477 . . _:b433397587 . _:b433399478 . _:b433399479 . _:b433397760 . _:b433399472 . _:b433399473 . _:b433397547 . _:b433399474 . _:b433399475 . _:b433397763 . _:b433399436 . . _:b433399437 . _:b433399438 . _:b433399439 . _:b433397762 . _:b433399432 . _:b433399433 . _:b433398046 . . _:b433399434 . _:b433399435 . . _:b433397773 . _:b433399126 . _:b433399428 . _:b433399429 . _:b433399430 . _:b433399431 . _:b433397772 . _:b433399424 . _:b433399425 . _:b433399426 . _:b433399532 . _:b433399427 . _:b433397775 . _:b433399452 . _:b433399453 . _:b433399454 . _:b433399455 . _:b433397774 . _:b433399448 . _:b433398130 . _:b433399449 . _:b433399450 . _:b433399451 . _:b433397769 . _:b433399444 . _:b433399186 . _:b433399445 . _:b433399446 . _:b433399447 . _:b433397768 . _:b433399440 . _:b433399441 . _:b433399442 . _:b433399443 . _:b433397771 . _:b433398241 . _:b433398973 . . _:b433397770 . _:b433397781 . . _:b433397780 . _:b433398123 . _:b433397783 . . _:b433397534 . _:b433398213 . _:b433397782 . . . . _:b433397777 . . _:b433397776 . _:b433397779 . . _:b433398637 . _:b433397778 . _:b433398430 . _:b433397789 . _:b433397788 . _:b433397791 . . _:b433397790 . _:b433398496 . _:b433397785 . . _:b433397784 . _:b433397787 . _:b433397786 . _:b433397797 . . . _:b433399157 . _:b433397796 . _:b433397799 . _:b433397435 . _:b433399363 . . _:b433399136 . _:b433397798 . _:b433397793 . . _:b433397792 . . _:b433397795 . _:b433397794 . _:b433397805 . . _:b433397804 . _:b433397807 . . _:b433397806 . . _:b433397801 . _:b433397800 . . _:b433397803 . _:b433397802 . _:b433398059 . . _:b433397813 . _:b433397812 . . _:b433397815 . . _:b433397291 . _:b433398817 . _:b433397814 . _:b433397809 . _:b7741805 "mouse over the last 15 yr has highlighted the diversity of the DCs family and the notion that distinct DCs types perform different immune functions (Villadangos and Schnorrer, 2007; Naik, 2008; Heath and Carbone, 2009; Merad and Manz, >>2009<<). Much attention has focused on the mouse CD8\u03B1+ DCs subset and its role in immunity and tolerance, which could potentially be harnessed for immunotherapy of multiple diseases (Shortman and Heath, 2010)." . _:b433398885 . _:b433397808 . . _:b433398776 . _:b433397180 . _:b433398192 . _:b433397811 . _:b433398949 . _:b433397810 . . _:b433397821 . . _:b433397820 . _:b433397823 . . _:b433397822 . _:b433397817 . _:b433399106 . _:b433397816 . . _:b433397819 . _:b433398647 . _:b433398593 . _:b433397818 . . . _:b433397829 . _:b433397852 . _:b433397828 . _:b433397831 . . . _:b433397830 . _:b433397825 . . _:b433397824 . _:b433399102 . _:b433399321 . . _:b433397827 . . _:b433397826 . _:b433399067 . _:b433397837 . _:b433397836 . _:b433398925 . _:b433397839 . _:b433397179 . _:b433397838 . _:b433397833 . . . _:b433397832 . . _:b433397835 . _:b433397834 . . _:b433397845 . . _:b433397844 . . . _:b433397847 . _:b433399368 . _:b433397846 . . . _:b433397841 . _:b433397840 . _:b433398017 . _:b433397843 . _:b433399107 . _:b433397842 . . _:b433398546 . _:b433397853 . _:b433397852 . _:b433398917 . _:b433397735 . _:b433397855 . _:b433399058 . _:b433397831 . _:b433397854 . . _:b433397849 . _:b433397848 . _:b433397851 . . _:b433397850 . _:b433397513 . _:b433397861 . _:b433397860 . _:b433397863 . . _:b433397862 . _:b433397857 . _:b433397856 . _:b433397172 . _:b433397859 . _:b433397858 . _:b433397869 . _:b433397732 . _:b433397868 . _:b433397871 . . _:b433397870 . _:b433397876 . _:b433397865 . _:b433397864 . . _:b433398000 . _:b433397867 . . _:b433397239 . _:b433397866 . . _:b433398437 . _:b433398488 . _:b433397877 . _:b433397284 . _:b433397876 . _:b433397879 . . . _:b433397878 . . _:b433397873 . _:b433397872 . _:b433397875 . _:b433398718 . _:b433397874 . _:b433397885 . _:b433397884 . _:b433398670 . _:b433397887 . . _:b433397837 . _:b433397886 . _:b433398406 . _:b433397881 . _:b433397964 . _:b433397880 . _:b433397883 . _:b433397882 . _:b433397893 . . _:b433397892 . _:b433399282 . _:b433397895 . _:b433397894 . _:b433397889 . _:b433398586 . _:b433397533 . _:b433397888 . _:b433397891 . _:b433397890 . _:b433398534 . _:b433397901 . . _:b433397160 . _:b433397900 . _:b433397903 . _:b433399481 . _:b433397902 . _:b433398930 . _:b433397897 . _:b433397896 . . _:b433397899 . _:b433398151 . _:b433397898 . . _:b433397909 . _:b433397374 . _:b433397908 . _:b433397416 . _:b433397911 . _:b433398375 . _:b433397157 . _:b433397910 . _:b7741830 "In contrast, BDCA3+ cells have also been found in human bronchioalveolar lavage fluid, lung, tonsils, dermis, decidua, and kidney (Demedts et al., 2005; Lindstedt et al., 2005; Narbutt et al., 2006; Tsoumakidou et al., >>2006<<; Ban et al., 2008; Fiore et al., 2008)." . . _:b433397905 . . _:b433397904 . _:b433397907 . _:b433397906 . _:b433397917 . _:b433397916 . _:b433399475 . _:b433397919 . _:b433397918 . _:b433397913 . _:b433397912 . _:b7741804 "subsets in the mouse over the last 15 yr has highlighted the diversity of the DCs family and the notion that distinct DCs types perform different immune functions (Villadangos and Schnorrer, 2007; Naik, 2008; Heath and Carbone, >>2009<<; Merad and Manz, 2009). Much attention has focused on the mouse CD8\u03B1+ DCs subset and its role in immunity and tolerance, which could potentially be harnessed for immunotherapy of multiple diseases (Shortman and Heath, 2010)." . _:b433397915 . . . _:b433397914 . _:b433397925 . . _:b433397924 . . . . _:b433397927 . . _:b433397926 . _:b433399461 . _:b433397921 . . _:b433397920 . . _:b433398663 . _:b433397923 . . _:b433397922 . . _:b433398028 . _:b433397407 . _:b433397933 . _:b433397932 . . _:b433397935 . _:b7741807 . _:b433397934 . . _:b433397929 . . _:b433398767 . _:b433397928 . _:b433397931 . . _:b433397930 . . _:b433397941 . . _:b433397940 . _:b433398174 . _:b433397943 . _:b433397942 . _:b433397937 . _:b433397979 . _:b433397936 . _:b433397678 . _:b433397939 . _:b433397938 . _:b433397949 . . _:b7741817 . _:b433397948 . . _:b433397951 . . _:b433397950 . . _:b433397945 . _:b433397944 . . _:b433397947 . _:b433398227 . . _:b433397946 . . _:b433397484 . _:b433397957 . _:b7741794 . _:b433397956 . . _:b433397959 . _:b433397958 . _:b433397953 . _:b433397952 . _:b433397955 . _:b433397848 . . . . . _:b433397954 . _:b433398632 . _:b433397965 . . . _:b433397964 . . _:b433397967 . _:b433397966 . _:b433397961 . _:b433397865 . _:b433397960 . . _:b433397963 . . _:b433397962 . _:b433397973 . _:b433397578 . _:b433397972 . . . _:b433397975 . . _:b433397974 . _:b433397797 . _:b433397809 . _:b433397969 . _:b433399391 . _:b433398212 . _:b433397968 . . _:b433398911 . _:b433397971 . _:b433398373 . . _:b433397970 . _:b433397981 . _:b433398209 . _:b433397980 . . . _:b433397983 . _:b433397992 . _:b433399160 . _:b433397982 . _:b433397589 . . _:b433399131 . _:b433398137 . _:b433397977 . . . _:b433397976 . _:b433397979 . _:b433397836 . _:b433397978 . _:b433398305 . _:b433397989 . . _:b433397988 . _:b433397991 . _:b433399382 . _:b433397990 . . . _:b433397985 . _:b433397984 . _:b433397987 . _:b433397986 . _:b433399016 . _:b433397997 . . _:b433397996 . . _:b433399175 . _:b433397210 . _:b433397999 . . _:b433399301 "2"^^ . _:b433397998 . _:b433397360 . _:b433399300 "2"^^ . _:b433397993 . _:b433397867 . _:b433399303 "2"^^ . _:b433397992 . . . _:b433399302 "2"^^ . . _:b433397995 . _:b433399297 "2"^^ . . _:b433397994 . _:b433399296 "2"^^ . _:b433398005 . _:b433399299 "2"^^ . _:b433398004 . _:b433399298 "2"^^ . _:b433398812 . _:b433398007 . _:b433399309 "2"^^ . _:b433398006 . _:b433399308 "2"^^ . _:b433398001 . . _:b433399311 "2"^^ . _:b433398000 . _:b433399310 "2"^^ . _:b433398003 . _:b433399305 "2"^^ . _:b433398002 . _:b7741834 . _:b433399199 . _:b433399304 "2"^^ . _:b433398013 . _:b433399030 . . _:b433399307 "2"^^ . _:b433398012 . _:b433399306 "2"^^ . _:b433398015 . _:b433399317 "2"^^ . _:b433398014 . _:b433399316 "2"^^ . _:b433398009 . . . _:b433399319 "2"^^ . _:b433398008 . _:b433398727 . _:b433399318 "2"^^ . _:b433397323 . _:b433398011 . _:b433399313 "2"^^ . _:b433398010 . _:b433399312 "2"^^ . _:b433399512 . _:b433399315 "2"^^ . _:b433399314 "2"^^ . . . _:b433399325 "2"^^ . _:b433397786 . . _:b433399324 "2"^^ . _:b433399327 "2"^^ . _:b433398861 . _:b433398952 . _:b433399326 "2"^^ . . . _:b433399321 "2"^^ . . . . _:b433399320 "2"^^ . _:b433399323 "2"^^ . . _:b433399322 "2"^^ . _:b433397177 . _:b433399333 "2"^^ . _:b433399332 "2"^^ . _:b433399335 "2"^^ . . _:b433399334 "2"^^ . _:b433399329 "2"^^ . _:b433399328 "2"^^ . . _:b433399331 "2"^^ . _:b433399330 "2"^^ . _:b433398532 . _:b433399341 "2"^^ . . _:b433399340 "2"^^ . . _:b433399193 . _:b433399343 "2"^^ . . _:b433399342 "2"^^ . _:b433399337 "2"^^ . _:b433397181 . _:b433399336 "2"^^ . _:b433397391 . _:b433399207 . _:b433399339 "2"^^ . . _:b433399338 "2"^^ . . . _:b433399349 "2"^^ . _:b433398262 . . . _:b433399348 "2"^^ . _:b433399206 . _:b433399351 "2"^^ . . _:b433398540 . _:b433399350 "2"^^ . _:b433399345 "2"^^ . . . . _:b433399344 "2"^^ . _:b7741779 "Antigen presentation assays were performed as previously described (Salio et al., >>2001<<; Faure et al., 2009) using HLA-A2\u2013restricted NY-ESO-1\u2013 or MelanA-specific CD8+ T cells." . _:b433399347 "2"^^ . _:b433397236 . _:b433399346 "2"^^ . _:b433397990 . _:b433399357 "2"^^ . _:b433399356 "2"^^ . _:b433397894 . _:b433399359 "2"^^ . _:b433399358 "2"^^ . _:b433399353 "2"^^ . _:b433399238 . _:b433397216 . _:b433399352 "2"^^ . _:b433398785 . _:b433399355 "2"^^ . _:b433398588 . _:b433399354 "2"^^ . . . _:b433399365 "2"^^ . . . _:b433399364 "2"^^ . _:b433397611 . . _:b433399367 "2"^^ . _:b433398270 . _:b433397679 . . _:b433399366 "2"^^ . _:b433399361 "2"^^ . _:b433398190 . . _:b433399360 "2"^^ . _:b433399363 "2"^^ . _:b7741793 . _:b7741798 "S4), underscoring the importance of DC maturation in promoting antigen processing and presentation (Inaba et al., >>2000<<; Delamarre et al., 2003)." . _:b433399362 "2"^^ . _:b433397700 . _:b7741806 . _:b433399373 "2"^^ . _:b433399372 "2"^^ . _:b433399161 . . _:b433399375 "2"^^ . _:b433399374 "2"^^ . _:b433397488 . _:b433398075 . _:b433399028 . _:b433399369 "2"^^ . _:b433397886 . _:b433399368 "2"^^ . _:b433399008 . _:b433399371 "2"^^ . _:b433399370 "2"^^ . _:b433399381 "2"^^ . _:b433399088 . _:b433399501 . _:b433399380 "2"^^ . _:b433399383 "2"^^ . _:b433398398 . _:b433399382 "2"^^ . . . _:b433399377 "2"^^ . . _:b433398344 . _:b433399376 "2"^^ . . _:b433397112 . _:b433399379 "2"^^ . . _:b433399378 "2"^^ . _:b433399389 "2"^^ . _:b7741796 "DNGR-1+ DCs were able to take dead cell material and were superior in this regard to monocyte-derived DCs (Mo-DCs) generated using GM-CSF + IL-4 (Sallusto et al., >>1995<<; Fig. 6 A). By microscopy, internalized dead cell material took the appearance of multiple small inclusions within a single DNGR-1+ DC (Fig. 6 A). Finally, we assessed the ability of DNGR-1+ BDCA3+ DCs to cross-present exogenous antigen" . _:b433399388 "2"^^ . . _:b433399391 "2"^^ . _:b433399154 . . _:b433399390 "2"^^ . _:b433399385 "2"^^ . _:b433399410 . . _:b433399384 "2"^^ . . _:b433399387 "2"^^ . . _:b433399386 "2"^^ . . . . _:b433399397 "2"^^ . _:b433399396 "2"^^ . _:b433399399 "2"^^ . _:b433399398 "2"^^ . _:b433397647 . _:b433399393 "2"^^ . . . _:b433399392 "2"^^ . _:b433397347 . _:b433398924 . _:b433399395 "2"^^ . . _:b433399394 "2"^^ . _:b433399140 . _:b433399405 "2"^^ . _:b433399404 "2"^^ . . _:b433399407 "2"^^ . _:b433399406 "2"^^ . _:b433399401 "2"^^ . _:b433399400 "2"^^ . _:b433397521 . _:b7741809 "ability to detect DNGR-1+ BDCA3hi DCs in human spleen cell suspensions is unlikely to be explained by blood contamination as DNGR-1+ BDCA3hi DCs represent 0.05% of PBMC (Caminschi et al., 2008; Huysamen et al., 2008; Sancho et al., >>2008<<), yet make up 0.1% of total splenocytes (Table S1). Thus, DNGR-1+ BDCA3hi human spleen DCs likely correspond to the rare Necl2+ cells previously found by immunofluorescence in human spleen sections (Galibert et al., 2005)." . _:b433399403 "2"^^ . _:b433398094 . _:b433399402 "2"^^ . . _:b433399413 "2"^^ . _:b433397184 . . _:b433399412 "2"^^ . _:b433399415 "2"^^ . _:b433399414 "2"^^ . . _:b433399289 . _:b433397681 . _:b433399409 "2"^^ . . . _:b433399408 "2"^^ . _:b433399411 "2"^^ . _:b433399410 "2"^^ . _:b433399349 . _:b433397335 . _:b433399421 "2"^^ . . _:b433399420 "2"^^ . _:b433397729 . _:b7741811 "a rare cell type, although it may also relate to the method used for preparation of the cell suspension as, in mouse, mechanical dissociation of spleen without enzymatic digestion selects against CD8\u03B1+ DC isolation (Vremec et al., >>1992<<). It will be interesting to extend our analysis to additional donors to determine if DNGR-1+ BDCA3hi human spleen DCs can show signs of in vivo activation related to bacterial infections or extent of trauma preceding death (McIlroy et al." . _:b433399423 "2"^^ . _:b433397401 . _:b433398203 . _:b433399422 "2"^^ . . . _:b433399417 "2"^^ . _:b433399416 "2"^^ . _:b7741793 "A hallmark of mouse CD8\u03B1+ DCs is their ability to produce high levels of IL-12 in response to TLR agonists, especially in synergy with signals through the CD40, IL-4, GM-CSF, or IFN-\u03B3 receptors (Shortman and Heath, >>2010<<). DNGR-1+ DCs purified from CBDC cultures produced no IL-12 p70 above background in response to stimulation with a cocktail of TLR agonists, even when these were given together with IL-4 and IFN-\u03B3 (Fig." . _:b433399419 "2"^^ . _:b433399418 "2"^^ . _:b433399429 "2"^^ . _:b433399428 "2"^^ . _:b433399431 "2"^^ . _:b433399430 "2"^^ . . _:b433399425 "2"^^ . . _:b433397692 . _:b433399424 "2"^^ . _:b433397883 . _:b433399427 "2"^^ . . _:b433399426 "2"^^ . _:b433399437 "2"^^ . _:b433397301 . _:b433398405 . _:b433399436 "2"^^ . _:b433399439 "2"^^ . _:b433399438 "2"^^ . _:b433399433 "2"^^ . . _:b433399432 "2"^^ . . _:b433399435 "2"^^ . _:b433397896 . _:b433399434 "2"^^ . _:b433398726 . . _:b433399445 "2"^^ . _:b433399444 "2"^^ . _:b433399447 "2"^^ . . _:b433399446 "2"^^ . _:b433399145 . _:b433399441 "2"^^ . _:b433399440 "2"^^ . . _:b433399375 . _:b433399443 "2"^^ . _:b433399442 "2"^^ . _:b433397509 . _:b433399453 "2"^^ . _:b433399452 "2"^^ . _:b433399455 "2"^^ . _:b433397823 . _:b433399454 "2"^^ . _:b433399449 "2"^^ . _:b433399448 "2"^^ . _:b433399451 "2"^^ . . _:b433399450 "2"^^ . . _:b433399461 "2"^^ . _:b433399460 "2"^^ . _:b433398629 . _:b433399463 "2"^^ . . _:b433399462 "2"^^ . _:b433399457 "2"^^ . _:b433399456 "2"^^ . _:b433398045 . _:b433399459 "2"^^ . . _:b433398612 . _:b433399458 "2"^^ . _:b433398223 . _:b433398351 . . _:b433399469 "2"^^ . _:b433397527 . _:b433399468 "2"^^ . _:b433397107 . _:b433398711 . _:b433399471 "2"^^ . _:b433399470 "2"^^ . . . . _:b433399124 . . _:b433399465 "2"^^ . . _:b433399464 "2"^^ . . _:b433399467 "2"^^ . . _:b433399466 "2"^^ . . _:b433399477 "2"^^ . _:b433397524 . . _:b433399498 . _:b433399476 "2"^^ . . _:b433399479 "2"^^ . . _:b433399478 "2"^^ . _:b433398996 . _:b433399473 "2"^^ . . _:b433397486 . . _:b433399472 "2"^^ . _:b433399475 "2"^^ . _:b433398927 . _:b433399474 "2"^^ . . _:b433398091 . _:b433399485 "2"^^ . _:b433397759 . _:b433398908 . . _:b433399484 "2"^^ . _:b433399487 "2"^^ . _:b433399486 "2"^^ . . _:b433399481 "2"^^ . _:b433399259 . _:b7741831 "contrast, BDCA3+ cells have also been found in human bronchioalveolar lavage fluid, lung, tonsils, dermis, decidua, and kidney (Demedts et al., 2005; Lindstedt et al., 2005; Narbutt et al., 2006; Tsoumakidou et al., 2006; Ban et al., >>2008<<; Fiore et al., 2008)." . _:b433399480 "2"^^ . _:b433397417 . _:b433399483 "2"^^ . . _:b433399482 "2"^^ . _:b433399493 "2"^^ . _:b433399492 "2"^^ . _:b433399495 "2"^^ . _:b433399494 "2"^^ . _:b433399489 "2"^^ . _:b433399488 "2"^^ . _:b433399491 "2"^^ . _:b433399490 "2"^^ . . _:b433399501 "2"^^ . _:b433398533 . _:b433399500 "2"^^ . . _:b433399503 "2"^^ . _:b433399502 "2"^^ . . _:b433399497 "2"^^ . _:b433399496 "2"^^ . _:b433398402 . _:b433399499 "2"^^ . . _:b433399498 "2"^^ . _:b433398315 . _:b433399509 "2"^^ . _:b433399508 "2"^^ . _:b433398087 . _:b433399511 "2"^^ . _:b433399062 . _:b433399510 "2"^^ . _:b433399505 "2"^^ . _:b433399504 "2"^^ . _:b433399507 "2"^^ . _:b433399506 "2"^^ . . _:b433398019 . _:b433399517 "2"^^ . _:b433399516 "2"^^ . _:b433398098 . . . _:b433399519 "2"^^ . _:b433398896 . _:b433399518 "2"^^ . . _:b433399513 "2"^^ . _:b433398683 . _:b433399466 . _:b433399512 "2"^^ . _:b433399515 "2"^^ . . _:b433399514 "2"^^ . . _:b433399525 "2"^^ . _:b433399524 "2"^^ . . _:b433399527 "2"^^ . _:b433399526 "2"^^ . _:b433399521 "2"^^ . _:b433398794 . . _:b433399520 "2"^^ . _:b433397717 . _:b433399523 "2"^^ . . _:b433399522 "2"^^ . . . _:b433399533 "2"^^ . _:b433399532 "2"^^ . . _:b433399535 "2"^^ . _:b433399534 "2"^^ . . _:b433399529 "2"^^ . _:b433398085 . . _:b433399528 "2"^^ . . . _:b433399531 "2"^^ . . _:b433399530 "2"^^ . _:b433399541 "2"^^ . _:b433399540 "2"^^ . _:b433399346 . _:b433398299 . _:b433399543 "2"^^ . _:b433398841 . . _:b433397834 . _:b433399542 "2"^^ . _:b433399537 "2"^^ . . _:b433399536 "2"^^ . . _:b433399539 "2"^^ . _:b433399538 "2"^^ . _:b433399549 "2"^^ . _:b433399548 "2"^^ . . . _:b433399545 "2"^^ . _:b433399544 "2"^^ . . _:b433399547 "2"^^ . _:b433398267 . . _:b433399546 "2"^^ . _:b433399438 . . _:b433397343 . . _:b433397609 . . . . _:b433398710 . _:b433397758 . . . _:b433397663 . . _:b433398325 . . . _:b433398735 . . _:b433398388 . . _:b433398635 . _:b433399263 . _:b433397958 . _:b433397173 . _:b433398069 . _:b433397198 . . . _:b433397477 . _:b433398029 . _:b433398472 . . _:b433397816 . _:b433398444 . _:b433397707 . _:b433398913 . . . . _:b433398988 . . _:b433397812 . _:b433397993 . _:b433398257 . _:b433398475 . _:b433399374 . . . . _:b433399117 . . . _:b433398025 . . _:b433399326 . . _:b433398650 . _:b433398761 . _:b433398842 . _:b7741796 . . . . . . _:b433397840 . _:b433398529 . . . _:b433397900 . . . . . . _:b433397936 . _:b433397460 . . _:b433398244 . . . . _:b433399535 . _:b433398914 . _:b433397140 . . _:b433398555 . _:b433398443 . _:b7741821 . . . . . _:b433398938 . . . . . . _:b433399239 . _:b433398803 . _:b433398260 . . . . _:b433397773 . _:b433398804 . . _:b7741775 . . _:b7741801 "discussion" . . _:b433398004 . _:b433399280 . . . . . . _:b433398771 . _:b433399499 . _:b433399361 . _:b433398616 . _:b433397532 . _:b433398769 . _:b433397862 . _:b433397607 . _:b433397213 . . . _:b433397972 . _:b433399390 . . . _:b433399344 . . . . _:b433398947 . _:b433397399 . _:b433399302 . _:b433397978 . . . . . _:b433397949 . _:b433397828 . . . . _:b433399443 . _:b433398966 . . . . . . . _:b433399143 . _:b433397585 . _:b433399315 . . _:b433397339 . _:b433398426 . . . . . _:b433399537 . . _:b433397701 . _:b433399303 . _:b433397365 . . _:b433397309 . _:b433397957 . . _:b433398702 . _:b433397443 . . _:b433398321 . . _:b433398497 . _:b433399429 . _:b433398708 . _:b433397163 . _:b433398682 . _:b7741820 "Although it is tempting to draw an analogy with Flt3L cultures of mouse bone marrow, which can generate both CD8\u03B1+-like and CD8\u03B1\u2212 DCs after 8\u201310 d of culture in Flt3L (Naik et al., >>2005<<), we found that DNGR-1\u2212 BDCA3\u2212 DCs are not equivalent to CD8\u03B1\u2212 DCs." . . _:b433397929 . . _:b433397967 . . . _:b433398556 . . . . _:b433397327 . . _:b433398539 . . . . . _:b433399482 . . _:b433397518 . . . _:b433398603 . . . . . _:b433397959 . . _:b433397199 . . . . _:b433398113 . _:b433397581 . _:b433398583 . _:b433398600 . _:b433397131 . . . _:b433398303 . _:b433398377 . . . _:b433398837 . _:b433398163 . . . . _:b433399234 . . _:b433399479 . _:b433399308 . . . _:b433397856 . _:b433397871 . . _:b433397858 . . _:b433399043 . _:b433398992 . . _:b433398235 . _:b433398733 . _:b433397891 . . . . . . . _:b433398159 . _:b433398789 "2"^^ . . _:b433398376 . _:b433398722 . _:b433398788 "2"^^ . _:b433398791 "2"^^ . . _:b433398790 "2"^^ . _:b433399329 . _:b433399272 . _:b433398785 "2"^^ . _:b433398411 . _:b433398784 "2"^^ . _:b433398787 "2"^^ . . . _:b433398786 "2"^^ . _:b433397471 . _:b433398797 "2"^^ . _:b433398796 "2"^^ . _:b433398799 "2"^^ . _:b433397669 . . _:b433398798 "2"^^ . _:b433397974 . _:b433398793 "2"^^ . _:b433399277 . _:b433398792 "2"^^ . . _:b433399456 . _:b433398795 "2"^^ . . . _:b433398794 "2"^^ . . . . _:b433398805 "2"^^ . _:b433397895 . _:b433398333 . _:b433397819 . _:b433398804 "2"^^ . . _:b433398807 "2"^^ . _:b433398806 "2"^^ . _:b433398110 . . _:b433398801 "2"^^ . _:b433398800 "2"^^ . _:b433397248 . . _:b433398803 "2"^^ . _:b433398802 "2"^^ . _:b433398347 . _:b433398813 "2"^^ . _:b433398812 "2"^^ . _:b433398815 "2"^^ . . _:b433398814 "2"^^ . _:b433398809 "2"^^ . _:b433398808 "2"^^ . _:b433398811 "2"^^ . _:b433398810 "2"^^ . _:b433398821 "2"^^ . . _:b433398820 "2"^^ . _:b433398823 "2"^^ . . _:b433398822 "2"^^ . _:b433398817 "2"^^ . _:b433398816 "2"^^ . . _:b433398819 "2"^^ . _:b7741782 "Successful generation of DCs from hematopoietic stem cells has been achieved for Langerhans cells and dermal DC equivalents (Klechevsky et al., >>2008<<). Therefore, we tried to generate DNGR-1+ DCs in vitro from human CB HSCs/HPCs (CB-derived DCs [CBDCs]). We set up cultures as a two step procedure: in the first step, HSCs/HPCs were amplified by culture in the presence of SCF, Flt3L," . _:b433398894 . . . _:b433398818 "2"^^ . . _:b433398829 "2"^^ . _:b433398828 "2"^^ . . _:b433398831 "2"^^ . _:b433398830 "2"^^ . _:b433398825 "2"^^ . . . _:b433398824 "2"^^ . _:b433397231 . _:b433398827 "2"^^ . _:b433398826 "2"^^ . _:b433398837 "2"^^ . _:b433399305 . _:b433398836 "2"^^ . _:b433398839 "2"^^ . . _:b433398838 "2"^^ . _:b433399146 . _:b433398833 "2"^^ . . . _:b433398832 "2"^^ . _:b433398835 "2"^^ . _:b433397479 . _:b433398834 "2"^^ . . . _:b433398544 . _:b433397566 . _:b433398845 "2"^^ . _:b433398844 "2"^^ . _:b433397693 . _:b433398847 "2"^^ . _:b433397493 . _:b433398846 "2"^^ . . _:b433398841 "2"^^ . _:b433398644 . _:b433398840 "2"^^ . _:b433399463 . _:b433398843 "2"^^ . _:b433397356 . _:b433398842 "2"^^ . _:b433398853 "2"^^ . _:b433398852 "2"^^ . _:b433398855 "2"^^ . . . _:b433398854 "2"^^ . . _:b433398849 "2"^^ . _:b433399181 . _:b433398848 "2"^^ . . _:b433398851 "2"^^ . . _:b433398850 "2"^^ . _:b433398861 "2"^^ . _:b433398835 . _:b433398860 "2"^^ . _:b433398863 "2"^^ . _:b433398862 "2"^^ . _:b433398522 . _:b433397800 . _:b433398857 "2"^^ . _:b433397779 . _:b433398856 "2"^^ . _:b433398859 "2"^^ . . _:b433398858 "2"^^ . _:b433398869 "2"^^ . _:b433398951 . _:b433399257 . _:b433398655 . _:b433398868 "2"^^ . _:b433398757 . _:b433398871 "2"^^ . _:b433398870 "2"^^ . . _:b433398865 "2"^^ . . _:b433398864 "2"^^ . . . . _:b433398867 "2"^^ . . _:b433398866 "2"^^ . _:b433398391 . _:b433398266 . _:b433398877 "2"^^ . _:b433399159 . _:b433398876 "2"^^ . _:b433399252 . . _:b433398879 "2"^^ . . _:b433398878 "2"^^ . _:b433398873 "2"^^ . _:b433398872 "2"^^ . . _:b433397558 . _:b433398875 "2"^^ . . _:b433398874 "2"^^ . _:b433399152 . . _:b433398885 "2"^^ . _:b433397288 . . _:b433398884 "2"^^ . _:b433398887 "2"^^ . _:b433398003 . . . _:b433398886 "2"^^ . . _:b433398881 "2"^^ . _:b433398880 "2"^^ . _:b433398883 "2"^^ . _:b433398882 "2"^^ . . _:b433398857 . _:b433398001 . _:b433398893 "2"^^ . _:b433398261 . _:b433398618 . _:b7741812 . _:b433398892 "2"^^ . . _:b433398895 "2"^^ . . _:b433398894 "2"^^ . _:b433399037 . _:b433398889 "2"^^ . . _:b433398888 "2"^^ . _:b433398891 "2"^^ . _:b433397712 . _:b433398890 "2"^^ . _:b433398901 "2"^^ . _:b433398900 "2"^^ . . _:b433398903 "2"^^ . . _:b433398902 "2"^^ . _:b433398897 "2"^^ . . _:b433397767 . _:b433398896 "2"^^ . . _:b433398899 "2"^^ . _:b433397194 . _:b433397390 . . _:b433398898 "2"^^ . . _:b433398909 "2"^^ . _:b433398908 "2"^^ . _:b433398911 "2"^^ . _:b433398910 "2"^^ . _:b433398905 "2"^^ . _:b433398904 "2"^^ . _:b433397673 . _:b433398907 "2"^^ . . _:b433398906 "2"^^ . _:b433399468 . _:b433398917 "2"^^ . . . _:b433398916 "2"^^ . . . _:b433398919 "2"^^ . _:b433398918 "2"^^ . . _:b433398013 . . _:b433398913 "2"^^ . _:b433398912 "2"^^ . _:b433398064 . _:b433398915 "2"^^ . _:b433398914 "2"^^ . _:b433397225 . . _:b433398925 "2"^^ . _:b433398924 "2"^^ . _:b433397798 . _:b433398927 "2"^^ . . _:b433397734 . . _:b433398926 "2"^^ . _:b433398077 . _:b433398921 "2"^^ . _:b433398435 . . _:b433398920 "2"^^ . _:b433397564 . _:b433398923 "2"^^ . _:b433398692 . _:b433398922 "2"^^ . _:b433398933 "2"^^ . _:b433397175 . _:b433398932 "2"^^ . _:b433398935 "2"^^ . _:b433397244 . _:b433398935 . _:b433398934 "2"^^ . . _:b433398929 "2"^^ . . _:b433399064 . _:b433398928 "2"^^ . . _:b433398931 "2"^^ . _:b433399520 . _:b433398930 "2"^^ . . . _:b433397353 . _:b433398941 "2"^^ . . _:b433398940 "2"^^ . _:b433397686 . _:b433398943 "2"^^ . _:b433398942 "2"^^ . _:b433398937 "2"^^ . _:b433398936 "2"^^ . . _:b433398939 "2"^^ . _:b433397382 . _:b433398015 . _:b433398938 "2"^^ . _:b433398949 "2"^^ . _:b433398608 . _:b433398948 "2"^^ . _:b433397289 . _:b433398951 "2"^^ . _:b433398950 "2"^^ . _:b433398945 "2"^^ . _:b433398944 "2"^^ . _:b433398279 . _:b433398327 . _:b433398947 "2"^^ . . _:b433398946 "2"^^ . . _:b433398957 "2"^^ . _:b433398956 "2"^^ . _:b433398959 "2"^^ . _:b433398958 "2"^^ . . _:b433397245 . _:b433398571 . _:b433398953 "2"^^ . _:b433398952 "2"^^ . _:b433398955 "2"^^ . _:b433398954 "2"^^ . _:b433397909 . _:b433398965 "2"^^ . . _:b433398964 "2"^^ . _:b433398902 . _:b433398967 "2"^^ . _:b433398966 "2"^^ . . . _:b433398961 "2"^^ . . . _:b433398960 "2"^^ . "PMC0" . . . _:b433398963 "2"^^ . _:b433398962 "2"^^ . _:b433398973 "2"^^ . . . . _:b433398972 "2"^^ . _:b433398975 "2"^^ . _:b433399508 . _:b433398974 "2"^^ . _:b433398969 "2"^^ . _:b433398968 "2"^^ . _:b433398971 "2"^^ . _:b433398970 "2"^^ . _:b433397601 . _:b433398981 "2"^^ . . _:b433399383 . . _:b433398980 "2"^^ . . _:b7741790 . _:b433398983 "2"^^ . _:b433397742 . _:b433398982 "2"^^ . . _:b433398977 "2"^^ . _:b433398976 "2"^^ . _:b433397864 . _:b433398979 "2"^^ . _:b433397229 . _:b433398470 . _:b433398978 "2"^^ . . . _:b433398989 "2"^^ . . . _:b433398988 "2"^^ . _:b433398676 . _:b433397472 . . . _:b433398991 "2"^^ . _:b433397775 . _:b433397782 . _:b433398990 "2"^^ . . _:b433398595 . _:b433397615 . _:b433398985 "2"^^ . _:b433398984 "2"^^ . _:b433398987 "2"^^ . . _:b433398986 "2"^^ . _:b7741785 . _:b433398997 "2"^^ . _:b433398996 "2"^^ . _:b433398999 "2"^^ . _:b433398998 "2"^^ . _:b433399335 . _:b433398993 "2"^^ . _:b433398992 "2"^^ . . . _:b433398995 "2"^^ . . _:b433398994 "2"^^ . . . . _:b433399005 "2"^^ . _:b433399004 "2"^^ . _:b433398143 . _:b433399007 "2"^^ . . _:b7741782 . _:b433398800 . _:b433399006 "2"^^ . _:b433398834 . . _:b433399001 "2"^^ . . _:b433397123 . _:b433399000 "2"^^ . _:b433399003 "2"^^ . _:b433399002 "2"^^ . _:b433398211 . _:b433399013 "2"^^ . _:b433399029 . . _:b433399012 "2"^^ . . . _:b433399015 "2"^^ . _:b433398955 . _:b433399014 "2"^^ . . _:b433399009 "2"^^ . . . _:b433399008 "2"^^ . _:b433399011 "2"^^ . . . _:b433399421 . _:b433399010 "2"^^ . _:b433398187 . _:b433399021 "2"^^ . _:b433397137 . _:b433399020 "2"^^ . _:b433399023 "2"^^ . _:b433399022 "2"^^ . _:b433398849 . _:b433398422 . . . _:b433399017 "2"^^ . . _:b433399019 . _:b433399016 "2"^^ . . _:b433399019 "2"^^ . _:b433398442 . _:b433399018 "2"^^ . _:b433399029 "2"^^ . _:b433397161 . _:b433399028 "2"^^ . _:b433399031 "2"^^ . _:b433399030 "2"^^ . . _:b433398366 . _:b433399025 "2"^^ . . . _:b433399024 "2"^^ . _:b433398434 . _:b433399027 "2"^^ . . _:b433399026 "2"^^ . _:b433399037 "2"^^ . _:b433399036 "2"^^ . . _:b433399187 . _:b433399039 "2"^^ . . _:b433399038 "2"^^ . _:b433399033 "2"^^ . _:b433399032 "2"^^ . . _:b7741774 "materials and methods" . _:b433399035 "2"^^ . _:b433399034 "2"^^ . _:b433399045 "2"^^ . _:b433399284 . _:b433398310 . _:b433399044 "2"^^ . . _:b433399047 "2"^^ . . _:b433398458 . . _:b433399137 . _:b433399046 "2"^^ . . _:b433397731 . _:b433399041 "2"^^ . _:b433399040 "2"^^ . _:b433398066 . _:b433399043 "2"^^ . _:b433397319 . _:b433399042 "2"^^ . _:b433399053 "2"^^ . _:b433399052 "2"^^ . _:b433398026 . _:b433398700 . _:b433399055 "2"^^ . _:b433398553 . _:b433399054 "2"^^ . _:b433398887 . . _:b433399049 "2"^^ . . _:b433399048 "2"^^ . _:b433399051 "2"^^ . . _:b433399050 "2"^^ . _:b433399061 "2"^^ . _:b433397674 . _:b433399060 "2"^^ . _:b433397190 . _:b433399063 "2"^^ . . _:b433399062 "2"^^ . _:b433399057 "2"^^ . _:b433399056 "2"^^ . . . _:b433398417 . _:b433399059 "2"^^ . . _:b433399058 "2"^^ . . _:b433399069 "2"^^ . _:b433399068 "2"^^ . _:b433399071 "2"^^ . _:b433399070 "2"^^ . _:b433399065 "2"^^ . _:b433398974 . _:b433399064 "2"^^ . _:b433399067 "2"^^ . . _:b433399066 "2"^^ . _:b433399077 "2"^^ . . _:b433399076 "2"^^ . _:b433398204 . _:b433399079 "2"^^ . _:b433399078 "2"^^ . _:b433399073 "2"^^ . . . _:b433399072 "2"^^ . _:b433399075 "2"^^ . _:b433397639 . _:b433397228 . _:b433399074 "2"^^ . _:b433399085 "2"^^ . _:b433398065 . . _:b433399129 . _:b433399084 "2"^^ . _:b433399347 . _:b433399087 "2"^^ . . _:b433399086 "2"^^ . . _:b433399081 "2"^^ . . _:b433398078 . _:b433399080 "2"^^ . . _:b433399083 "2"^^ . . _:b433399082 "2"^^ . . _:b433399093 "2"^^ . _:b433399092 "2"^^ . _:b433399177 . _:b433399095 "2"^^ . _:b433398609 . _:b433399224 . _:b433399094 "2"^^ . _:b433399089 "2"^^ . _:b433399088 "2"^^ . _:b433399091 "2"^^ . _:b433399090 "2"^^ . . _:b433399101 "2"^^ . _:b433397954 . _:b433399100 "2"^^ . _:b7741835 . _:b433397971 . _:b433399103 "2"^^ . . _:b433399102 "2"^^ . _:b433397320 . _:b433399097 "2"^^ . _:b433399096 "2"^^ . _:b433399099 "2"^^ . _:b433399098 "2"^^ . . _:b433399109 "2"^^ . _:b433399108 "2"^^ . _:b433398399 . . _:b433399111 "2"^^ . _:b433399110 "2"^^ . _:b433397569 . _:b433399105 "2"^^ . _:b433399104 "2"^^ . _:b433399107 "2"^^ . . . _:b433399106 "2"^^ . _:b433399117 "2"^^ . _:b433399116 "2"^^ . _:b433399119 "2"^^ . _:b433398747 . _:b433399118 "2"^^ . _:b433399364 . _:b433399113 "2"^^ . _:b7741797 "CBDCs were at least as efficient as Mo-DCs at activating NY-ESO-1157-165\u2013specific T cells in response to intact recombinant NY-ESO-1 protein, a clinically relevant antigen expressed by a broad range of tumor types (Chen et al., >>2005<<; Fig. S4)." . _:b433399112 "2"^^ . . . _:b433399115 "2"^^ . _:b433399114 "2"^^ . . _:b433397217 . _:b433399125 "2"^^ . _:b433399124 "2"^^ . . _:b433399127 "2"^^ . . _:b433399336 . _:b433399126 "2"^^ . _:b433399121 "2"^^ . _:b433398208 . _:b433397588 . _:b433399120 "2"^^ . . _:b433399123 "2"^^ . _:b433399090 . . _:b433399122 "2"^^ . _:b433398220 . . _:b433399133 "2"^^ . _:b433399132 "2"^^ . _:b433397178 . . _:b433399135 "2"^^ . _:b433399134 "2"^^ . _:b433399129 "2"^^ . . . _:b433398542 . _:b433399128 "2"^^ . . . _:b433397685 . _:b433399131 "2"^^ . _:b433399130 "2"^^ . . _:b433399141 "2"^^ . . _:b433399140 "2"^^ . _:b433399143 "2"^^ . . _:b433399142 "2"^^ . . . _:b433399137 "2"^^ . _:b433397902 . _:b433399256 . _:b433399136 "2"^^ . _:b433399139 "2"^^ . _:b433399387 . _:b433399138 "2"^^ . _:b433399149 "2"^^ . _:b433398487 . _:b433399148 "2"^^ . _:b433398084 . _:b433399151 "2"^^ . _:b433399150 "2"^^ . _:b433399145 "2"^^ . . _:b433399144 "2"^^ . . _:b433399147 "2"^^ . . _:b433399146 "2"^^ . . . _:b433399157 "2"^^ . . _:b7741786 "3 D), perhaps because of GM-CSF\u2013driven induction of CD1a-c family members (Porcelli et al., >>1992<<). CB-derived DNGR-1+ BDCA3+ DCs expressed CD86 and CD45RO, but only low levels of CD123 (Fig. 3 D), as reported for blood BDCA3+ DCs (MacDonald et al., 2002). In contrast to mouse CD8\u03B1+ DCs, DNGR-1+ BDCA3+ DCs did not express CD8\u03B1 or" . _:b433398578 . _:b433399156 "2"^^ . . . _:b433399159 "2"^^ . _:b433398805 . _:b433399158 "2"^^ . _:b433398495 . . _:b433399153 "2"^^ . _:b433399152 "2"^^ . _:b433399155 "2"^^ . _:b433397226 . _:b433399154 "2"^^ . _:b433399165 "2"^^ . _:b433399164 "2"^^ . . _:b433399167 "2"^^ . _:b433399166 "2"^^ . _:b433399161 "2"^^ . . . _:b433399160 "2"^^ . _:b433397156 . _:b433399163 "2"^^ . . . _:b433399162 "2"^^ . . _:b433399173 "2"^^ . _:b433397189 . _:b433398870 . . _:b433399172 "2"^^ . _:b433399175 "2"^^ . _:b433399218 . _:b433397653 . . _:b433399174 "2"^^ . . _:b433398181 . _:b433399169 "2"^^ . . _:b433399168 "2"^^ . _:b433399171 "2"^^ . _:b433399170 "2"^^ . . _:b433399181 "2"^^ . _:b433399180 "2"^^ . . _:b433397267 . _:b433399183 "2"^^ . . _:b433399182 "2"^^ . . _:b433398219 . _:b433399177 "2"^^ . _:b433398694 . _:b433399176 "2"^^ . . _:b433399179 "2"^^ . _:b433399178 "2"^^ . . _:b433399189 "2"^^ . . _:b433399188 "2"^^ . _:b433399191 "2"^^ . . _:b433399190 "2"^^ . _:b433399185 "2"^^ . _:b433397186 . _:b433397434 . _:b433399184 "2"^^ . _:b433399187 "2"^^ . _:b433399186 "2"^^ . _:b433398238 . _:b433399197 "2"^^ . _:b433399196 "2"^^ . _:b433399199 "2"^^ . . _:b433397283 . _:b433399198 "2"^^ . _:b433399193 "2"^^ . _:b433397387 . _:b433399192 "2"^^ . _:b433398469 . _:b433399195 "2"^^ . _:b433398666 . _:b433398423 . _:b433399194 "2"^^ . . _:b433399205 "2"^^ . _:b433399204 "2"^^ . _:b433398290 . _:b433399207 "2"^^ . . _:b433399206 "2"^^ . . _:b433399201 "2"^^ . . . _:b433399200 "2"^^ . . _:b433399203 "2"^^ . _:b433399056 . _:b433397892 . _:b433399202 "2"^^ . . _:b433398018 . _:b433399213 "2"^^ . _:b433399212 "2"^^ . . _:b433399215 "2"^^ . _:b433397573 . _:b433398642 . _:b433399214 "2"^^ . _:b433399209 "2"^^ . _:b433398460 . _:b433399208 "2"^^ . . . _:b433399211 "2"^^ . _:b433399210 "2"^^ . _:b433399221 "2"^^ . . _:b433399220 "2"^^ . _:b433398968 . _:b433399223 "2"^^ . _:b433399222 "2"^^ . _:b433399217 "2"^^ . . _:b433399216 "2"^^ . _:b433399219 "2"^^ . _:b433399218 "2"^^ . _:b433399440 . _:b433399333 . _:b433399229 "2"^^ . _:b433399228 "2"^^ . _:b433399231 "2"^^ . _:b433399230 "2"^^ . . _:b433399225 "2"^^ . _:b433399224 "2"^^ . _:b433399227 "2"^^ . _:b433397211 . _:b433399226 "2"^^ . . _:b433399237 "2"^^ . . _:b433399236 "2"^^ . _:b433397406 . _:b433399239 "2"^^ . _:b433398606 . . _:b433399171 . _:b433399238 "2"^^ . _:b433399233 "2"^^ . . _:b433399232 "2"^^ . . _:b433399235 "2"^^ . . . _:b433399234 "2"^^ . _:b433397960 . _:b433399245 "2"^^ . _:b433399244 "2"^^ . _:b433399247 "2"^^ . _:b433397801 . _:b433399246 "2"^^ . _:b433399241 "2"^^ . _:b433399254 . _:b433399240 "2"^^ . . _:b433399243 "2"^^ . _:b433399545 . . _:b433399242 "2"^^ . . _:b433397132 . _:b433399253 "2"^^ . . . _:b433399252 "2"^^ . _:b433399022 . _:b433399255 "2"^^ . _:b433399254 "2"^^ . _:b433397572 . _:b433398341 . _:b433399249 "2"^^ . . _:b433399248 "2"^^ . _:b433397826 . . _:b433399251 "2"^^ . . _:b433399250 "2"^^ . _:b433399261 "2"^^ . _:b433399260 "2"^^ . _:b433397552 . . _:b433399263 "2"^^ . _:b433399528 . _:b433399262 "2"^^ . _:b433399257 "2"^^ . _:b433397602 . _:b433399256 "2"^^ . _:b433399259 "2"^^ . _:b433399258 "2"^^ . _:b433399269 "2"^^ . _:b433399268 "2"^^ . _:b433399271 "2"^^ . . _:b433399270 "2"^^ . _:b433398970 . . _:b433399265 "2"^^ . . _:b433397696 . _:b433399264 "2"^^ . _:b433398474 . _:b433399267 "2"^^ . . _:b433398361 . _:b433399266 "2"^^ . _:b433399277 "2"^^ . _:b433398634 . . _:b433399276 "2"^^ . _:b433399279 "2"^^ . . _:b433399278 "2"^^ . . _:b433397351 . _:b433397815 . _:b433399273 "2"^^ . _:b7741810 . _:b433399272 "2"^^ . . . _:b433399275 "2"^^ . _:b433399069 . _:b433399274 "2"^^ . _:b433399285 "2"^^ . _:b433399284 "2"^^ . _:b433397889 . _:b433399324 . . _:b433399287 "2"^^ . _:b433397169 . _:b433399286 "2"^^ . _:b433398518 . _:b433399425 . _:b433399281 "2"^^ . _:b433399280 "2"^^ . _:b433398875 . _:b433399371 . _:b433399283 "2"^^ . _:b433399060 . _:b433399282 "2"^^ . . _:b433399293 "2"^^ . _:b433399292 "2"^^ . . _:b433399295 "2"^^ . _:b433399294 "2"^^ . _:b7741787 "3 D), as reported for blood BDCA3+ DCs (MacDonald et al., >>2002<<). In contrast to mouse CD8\u03B1+ DCs, DNGR-1+ BDCA3+ DCs did not express CD8\u03B1 or CD103." . _:b433397392 . _:b433399289 "2"^^ . _:b433398503 . _:b433399288 "2"^^ . . . _:b433399291 "2"^^ . _:b433398043 . . _:b433399290 "2"^^ . _:b433398669 . _:b433398277 "2"^^ . _:b433398810 . . _:b433397697 . _:b433397457 . _:b433398276 "2"^^ . _:b433398630 . . _:b433398279 "2"^^ . . . _:b433397991 . _:b433398450 . _:b433398278 "2"^^ . _:b433398950 . _:b433398273 "2"^^ . . _:b433398272 "2"^^ . _:b433398275 "2"^^ . _:b433398274 "2"^^ . _:b433398285 "2"^^ . . _:b433398604 . _:b433398284 "2"^^ . _:b7741783 . . _:b433398287 "2"^^ . _:b433398286 "2"^^ . _:b433397369 . . _:b433398281 "2"^^ . _:b433397451 . _:b433398280 "2"^^ . _:b433398283 "2"^^ . _:b433398868 . _:b433399133 . _:b433398282 "2"^^ . . _:b433398293 "2"^^ . _:b433397282 . _:b433398292 "2"^^ . _:b433399459 . _:b433399057 . _:b433398295 "2"^^ . _:b433398355 . . . _:b433398294 "2"^^ . _:b433398289 "2"^^ . _:b433398288 "2"^^ . _:b433397453 . _:b433397912 . _:b433398291 "2"^^ . _:b433398290 "2"^^ . _:b433398301 "2"^^ . _:b433398031 . _:b433398300 "2"^^ . _:b433398303 "2"^^ . _:b7741818 "Notably, we and others have shown that antigen targeting to DNGR-1 is a useful strategy for inducing CTL responses and antibody responses in mice (Caminschi et al., 2008; Sancho et al., >>2008<<), and can additionally be used to generate Th1 and Th17 or for converting antigen-specific CD4+ T cells into regulatory T cells (Joffre et al., 2010)." . _:b433398302 "2"^^ . _:b433398297 "2"^^ . _:b433398296 "2"^^ . _:b433398299 "2"^^ . _:b433398298 "2"^^ . _:b433399212 . _:b433397258 . _:b433398309 "2"^^ . . _:b433399158 . _:b433398308 "2"^^ . _:b433397487 . . _:b433398311 "2"^^ . _:b433398310 "2"^^ . . _:b433398096 . _:b433398305 "2"^^ . _:b433398304 "2"^^ . _:b433398801 . _:b433398307 "2"^^ . _:b433398306 "2"^^ . _:b433399436 . _:b433398665 . _:b433398317 "2"^^ . _:b433398316 "2"^^ . _:b433398982 . _:b433398319 "2"^^ . _:b433398318 "2"^^ . _:b433398313 "2"^^ . _:b433398512 . _:b433398312 "2"^^ . _:b433398315 "2"^^ . _:b433398314 "2"^^ . _:b433398948 . _:b433398325 "2"^^ . . . _:b433398324 "2"^^ . _:b433399397 . _:b433398327 "2"^^ . _:b433398326 "2"^^ . _:b433398321 "2"^^ . _:b433398320 "2"^^ . . _:b433398323 "2"^^ . . _:b433398322 "2"^^ . _:b433398409 . . _:b433398333 "2"^^ . _:b433399300 . _:b433398332 "2"^^ . _:b433398916 . _:b433398335 "2"^^ . _:b433397174 . _:b433398334 "2"^^ . _:b7741812 "will be interesting to extend our analysis to additional donors to determine if DNGR-1+ BDCA3hi human spleen DCs can show signs of in vivo activation related to bacterial infections or extent of trauma preceding death (McIlroy et al., >>2001<<)." . _:b433398329 "2"^^ . . . _:b433398328 "2"^^ . . _:b433398331 "2"^^ . _:b433398330 "2"^^ . _:b433398341 "2"^^ . . _:b433399454 . _:b433398340 "2"^^ . . _:b433398413 . . _:b433398343 "2"^^ . _:b433398106 . _:b433398342 "2"^^ . . . _:b433398337 "2"^^ . _:b433398183 . _:b7741800 . _:b433398336 "2"^^ . _:b433398313 . _:b433399053 . _:b433398339 "2"^^ . _:b433398338 "2"^^ . . _:b433398349 "2"^^ . _:b433398298 . _:b433398348 "2"^^ . _:b433398351 "2"^^ . _:b433398350 "2"^^ . _:b433398345 "2"^^ . _:b433398344 "2"^^ . _:b433399189 . _:b433398347 "2"^^ . _:b433399296 . _:b433398346 "2"^^ . _:b433398357 "2"^^ . . _:b433398356 "2"^^ . _:b433399496 . _:b433399531 . _:b433398359 "2"^^ . . _:b433398358 "2"^^ . . _:b433398353 "2"^^ . . _:b433398352 "2"^^ . _:b433398845 . _:b433398355 "2"^^ . . _:b433398354 "2"^^ . _:b433397271 . _:b433398365 "2"^^ . _:b433398364 "2"^^ . _:b433399491 . _:b433399080 . . _:b433398367 "2"^^ . . _:b433398366 "2"^^ . . _:b433398361 "2"^^ . . _:b433397687 . _:b433398360 "2"^^ . . _:b433398363 "2"^^ . . . _:b433398362 "2"^^ . _:b433398373 "2"^^ . _:b433397098 . . _:b433398372 "2"^^ . _:b433397099 . _:b433398375 "2"^^ . _:b433397100 . . _:b433398374 "2"^^ . _:b433398369 "2"^^ . _:b433397643 . _:b433399542 . _:b433398368 "2"^^ . . _:b433398371 "2"^^ . _:b433398370 "2"^^ . _:b433399185 . _:b433397966 . . _:b433398381 "2"^^ . . _:b433398380 "2"^^ . _:b433397737 . . _:b433398383 "2"^^ . _:b433398382 "2"^^ . _:b433398377 "2"^^ . . _:b433397855 . _:b433398376 "2"^^ . . . . _:b433398379 "2"^^ . . _:b433398378 "2"^^ . _:b433398134 . _:b433398389 "2"^^ . _:b433398388 "2"^^ . _:b7741780 . _:b433398391 "2"^^ . _:b433398390 "2"^^ . _:b433399196 . _:b433398385 "2"^^ . _:b433398384 "2"^^ . . _:b433398387 "2"^^ . . _:b433398386 "2"^^ . _:b433398397 "2"^^ . . _:b433399134 . _:b433398396 "2"^^ . . _:b433398399 "2"^^ . . _:b433399258 . _:b433397788 . _:b433398398 "2"^^ . _:b433398393 "2"^^ . _:b433398392 "2"^^ . _:b433398395 "2"^^ . . _:b433397316 . _:b433398840 . . _:b433398394 "2"^^ . _:b7741816 "This is similar to the situation with DEC-205 in the mouse, which is expressed at highest level on CD8\u03B1+ DCs and Langerhans cells, but is also expressed by other cell types (Witmer-Pack et al., >>1995<<). Worryingly, we have noticed that use of dim fluorophores or inefficient flow cytometer calibration can result in contamination of the BDCA3hi population with BDCA3int cells and, during cell sorting, lead to false PCR results" . _:b433398405 "2"^^ . . _:b433398404 "2"^^ . _:b433397386 . _:b7741801 . _:b7741828 "In contrast, BDCA3+ cells have also been found in human bronchioalveolar lavage fluid, lung, tonsils, dermis, decidua, and kidney (Demedts et al., 2005; Lindstedt et al., >>2005<<; Narbutt et al., 2006; Tsoumakidou et al., 2006; Ban et al., 2008; Fiore et al., 2008)." . _:b433398407 "2"^^ . _:b433398406 "2"^^ . _:b433398401 "2"^^ . _:b433399084 . _:b433398400 "2"^^ . _:b433397680 . . _:b433398403 "2"^^ . _:b7741781 . _:b433398402 "2"^^ . . _:b433398413 "2"^^ . _:b7741774 . _:b433398412 "2"^^ . _:b433398415 "2"^^ . . _:b433399216 . _:b433398414 "2"^^ . _:b433398409 "2"^^ . _:b433398737 . _:b433398408 "2"^^ . _:b433398411 "2"^^ . _:b433398410 "2"^^ . _:b433398337 . _:b433398421 "2"^^ . _:b433398420 "2"^^ . _:b433399038 . _:b433398423 "2"^^ . _:b433398422 "2"^^ . _:b433397774 . _:b433397295 . _:b433398417 "2"^^ . _:b433398416 "2"^^ . _:b433399240 . _:b433397945 . _:b433398419 "2"^^ . . _:b433397200 . . _:b433398764 . _:b433398418 "2"^^ . _:b433398429 "2"^^ . . _:b433399095 . _:b433398428 "2"^^ . _:b433397103 . _:b433398431 "2"^^ . _:b433398430 "2"^^ . _:b433397544 . _:b433398425 "2"^^ . . _:b433398424 "2"^^ . _:b433398427 "2"^^ . _:b433398668 . _:b433397375 . _:b433398426 "2"^^ . . _:b433398081 . _:b433398437 "2"^^ . _:b433398436 "2"^^ . _:b433398259 . _:b433398439 "2"^^ . . _:b433398640 . _:b433398438 "2"^^ . . _:b433398433 "2"^^ . _:b433398432 "2"^^ . _:b433398435 "2"^^ . _:b433398434 "2"^^ . . . _:b433398445 "2"^^ . _:b433399486 . _:b433398444 "2"^^ . . _:b433398198 . _:b433398447 "2"^^ . . . _:b433398446 "2"^^ . . _:b433398441 "2"^^ . . _:b433398440 "2"^^ . _:b433398364 . _:b433399048 . _:b433398443 "2"^^ . . _:b433398032 . _:b433398442 "2"^^ . . _:b433398453 "2"^^ . _:b433398865 . _:b433398636 . . . _:b433398452 "2"^^ . . _:b433398455 "2"^^ . _:b433398454 "2"^^ . _:b433399087 . _:b433398449 "2"^^ . _:b433398175 . _:b433398448 "2"^^ . _:b433398076 . . _:b433398451 "2"^^ . . _:b433398320 . _:b433398450 "2"^^ . _:b433398461 "2"^^ . . _:b433398460 "2"^^ . _:b433397220 . . _:b433399492 . _:b433398463 "2"^^ . _:b433398462 "2"^^ . _:b433398457 "2"^^ . _:b433398456 "2"^^ . _:b433397304 . _:b433398459 "2"^^ . _:b433398458 "2"^^ . _:b433398469 "2"^^ . _:b433398352 . _:b433398468 "2"^^ . _:b433397877 . _:b433398836 . . _:b433398471 "2"^^ . _:b433398922 . . _:b433398470 "2"^^ . . _:b433398465 "2"^^ . _:b433398464 "2"^^ . . . _:b433398467 "2"^^ . . . . _:b433398466 "2"^^ . . _:b433398477 "2"^^ . . . _:b433398476 "2"^^ . _:b433399138 . _:b433399132 . _:b433398479 "2"^^ . . . _:b433398478 "2"^^ . _:b433397297 . . _:b433398473 "2"^^ . _:b433398472 "2"^^ . _:b433398475 "2"^^ . . _:b433398474 "2"^^ . _:b433398485 "2"^^ . _:b433398484 "2"^^ . . _:b433398487 "2"^^ . _:b433398486 "2"^^ . _:b433398481 "2"^^ . _:b433398466 . _:b433398480 "2"^^ . . _:b433398483 "2"^^ . . _:b433398482 "2"^^ . _:b433398493 "2"^^ . . _:b433398492 "2"^^ . _:b433398495 "2"^^ . _:b433398494 "2"^^ . _:b433397708 . _:b433398489 "2"^^ . _:b433398488 "2"^^ . _:b433399182 . _:b433399290 . _:b433398491 "2"^^ . _:b433398490 "2"^^ . . _:b433398501 "2"^^ . . _:b433398500 "2"^^ . _:b433397662 . _:b433398503 "2"^^ . _:b433398502 "2"^^ . _:b433397619 . _:b433398497 "2"^^ . _:b433398496 "2"^^ . . _:b433398499 "2"^^ . _:b433398680 . _:b433398498 "2"^^ . _:b433398509 "2"^^ . . _:b433398508 "2"^^ . . _:b433397183 . . _:b433398511 "2"^^ . . . . _:b433399340 . _:b433398510 "2"^^ . . . _:b433398774 . _:b433398505 "2"^^ . . _:b433397644 . _:b433398109 . _:b433397859 . _:b433398504 "2"^^ . . _:b7741791 "In the mouse, where there is lack of functional TLR8 expression, these compounds have been defined as TLR7 agonists (Diebold et al., >>2004<<). However, in the human, they are reported to additionally stimulate TLR8 (Heil et al., 2004). The potent response of DNGR-1+ BDCA3+ DCs to resiquimod and poly U, but not imiquimod, indicates that these cells can express functional TLR8." . _:b433398507 "2"^^ . . _:b433398506 "2"^^ . . . _:b433398517 "2"^^ . . _:b433398516 "2"^^ . _:b433399503 . _:b433398519 "2"^^ . _:b433398518 "2"^^ . _:b433398513 "2"^^ . _:b433398512 "2"^^ . _:b433398141 . _:b433398515 "2"^^ . . _:b433398514 "2"^^ . _:b433398525 "2"^^ . . _:b433398524 "2"^^ . _:b433398527 "2"^^ . _:b433398232 . _:b433397839 . _:b433398526 "2"^^ . . _:b433397287 . _:b433398521 "2"^^ . _:b433399253 . _:b433398520 "2"^^ . _:b433399313 . _:b433398264 . _:b433398523 "2"^^ . _:b433398522 "2"^^ . _:b433398533 "2"^^ . . _:b433398991 . _:b433398532 "2"^^ . _:b433397551 . _:b433398959 . . . _:b433398535 "2"^^ . _:b433397756 . _:b433398246 . . _:b433398534 "2"^^ . . _:b433398858 . _:b433398529 "2"^^ . . _:b433397691 . _:b433398528 "2"^^ . . _:b433398531 "2"^^ . _:b433398530 "2"^^ . _:b433397576 . _:b433398012 . _:b433398541 "2"^^ . _:b433398787 . . _:b433398540 "2"^^ . _:b433399432 . _:b433398543 "2"^^ . _:b433399414 . _:b433398542 "2"^^ . . _:b433398537 "2"^^ . _:b433398536 "2"^^ . _:b433397975 . _:b433398539 "2"^^ . _:b433397739 . _:b433398538 "2"^^ . . . _:b433398549 "2"^^ . _:b433398548 "2"^^ . _:b433398551 "2"^^ . _:b7741774 . . _:b433398550 "2"^^ . _:b7741775 . _:b433397120 . _:b433397935 . _:b433398545 "2"^^ . . _:b433398544 "2"^^ . _:b433397923 . _:b433398547 "2"^^ . . _:b433398088 . . . _:b433398546 "2"^^ . _:b433398071 . _:b433398758 . _:b433398557 "2"^^ . _:b7741780 . . . _:b433398556 "2"^^ . _:b7741781 . _:b433398559 "2"^^ . _:b7741782 . . _:b433398558 "2"^^ . _:b7741783 . _:b433397345 . _:b433398553 "2"^^ . _:b7741776 . _:b433398552 "2"^^ . _:b7741777 . . _:b433398555 "2"^^ . _:b7741778 . . _:b433398554 "2"^^ . _:b7741779 . . _:b433398565 "2"^^ . _:b7741788 . _:b433399471 . _:b433398564 "2"^^ . _:b7741789 . _:b433398567 "2"^^ . _:b7741790 . _:b433398566 "2"^^ . _:b7741791 . . _:b433398561 "2"^^ . _:b7741784 . . _:b433397396 . _:b433398751 . _:b433398560 "2"^^ . _:b7741785 . . _:b433398563 "2"^^ . _:b7741786 . . _:b433398562 "2"^^ . _:b7741787 . . _:b433398573 "2"^^ . _:b7741796 . _:b433398572 "2"^^ . _:b7741797 . _:b433398575 "2"^^ . _:b7741798 . . _:b433398574 "2"^^ . _:b7741799 . _:b433399413 . _:b433398876 . _:b433398569 "2"^^ . _:b7741792 . . _:b433398847 . _:b433398839 . _:b433398568 "2"^^ . _:b7741793 . _:b433398571 "2"^^ . _:b7741794 . _:b433398691 . _:b433398570 "2"^^ . _:b7741795 . _:b433398581 "2"^^ . _:b7741804 . . _:b433398580 "2"^^ . _:b7741805 . . _:b433398583 "2"^^ . _:b7741806 . _:b433397814 . _:b433399388 . . _:b433398582 "2"^^ . _:b7741807 . _:b433397645 . _:b433398577 "2"^^ . _:b7741800 . . _:b433398576 "2"^^ . _:b7741801 . _:b433398579 "2"^^ . _:b7741802 . _:b433398578 "2"^^ . _:b7741803 . _:b433398589 "2"^^ . _:b7741812 . _:b433398588 "2"^^ . _:b7741813 . . _:b433398591 "2"^^ . _:b7741814 . _:b433398590 "2"^^ . _:b7741815 . . _:b433398585 "2"^^ . _:b7741808 . _:b433397196 . _:b433398584 "2"^^ . _:b7741809 . _:b433397849 . . . _:b433398587 "2"^^ . _:b7741810 . _:b433398586 "2"^^ . _:b7741811 . . _:b433398597 "2"^^ . _:b7741820 . _:b433398596 "2"^^ . _:b7741821 . . _:b433398599 "2"^^ . _:b7741822 . _:b433398598 "2"^^ . _:b7741823 . _:b433398593 "2"^^ . _:b7741816 . _:b433399543 . _:b433398592 "2"^^ . _:b7741817 . . _:b433398595 "2"^^ . _:b7741818 . . _:b433397963 . _:b433398594 "2"^^ . _:b7741819 . _:b433398986 . . _:b433398424 . _:b433397119 . _:b433398605 "2"^^ . _:b7741828 . _:b433398604 "2"^^ . _:b7741829 . _:b433398607 "2"^^ . _:b7741830 . _:b433398606 "2"^^ . _:b7741831 . _:b433397420 . _:b433398601 "2"^^ . _:b7741824 . . _:b433398600 "2"^^ . _:b7741825 . _:b433397841 . _:b433399096 . _:b433398603 "2"^^ . _:b7741826 . _:b433399304 . _:b433397292 . _:b433398180 . _:b433398602 "2"^^ . _:b7741827 . . _:b433398613 "2"^^ . _:b7741836 . _:b433399504 . . _:b433398612 "2"^^ . _:b433397205 . . _:b433397308 . . _:b433398615 "2"^^ . _:b433398292 . _:b433398614 "2"^^ . _:b433398609 "2"^^ . _:b7741832 . _:b433397702 . _:b433397987 . . _:b433397783 . _:b7741833 . _:b433397818 . _:b433398608 "2"^^ . _:b433399221 . _:b433398611 "2"^^ . _:b7741834 . _:b433398524 . _:b433398610 "2"^^ . _:b7741835 . _:b433398621 "2"^^ . _:b433398340 . _:b433398620 "2"^^ . _:b433397626 . _:b433398623 "2"^^ . . _:b433398622 "2"^^ . _:b433399547 . _:b433398617 "2"^^ . _:b433398899 . _:b433398616 "2"^^ . _:b433397716 . _:b433398619 "2"^^ . . . . _:b433398618 "2"^^ . . _:b433398629 "2"^^ . _:b433398628 "2"^^ . . _:b433397890 . _:b433398631 "2"^^ . _:b433397491 . _:b433398630 "2"^^ . _:b433398625 "2"^^ . . . _:b433398624 "2"^^ . _:b433398627 "2"^^ . . _:b433398626 "2"^^ . _:b433398637 "2"^^ . _:b433398636 "2"^^ . _:b433398639 "2"^^ . _:b433398638 "2"^^ . _:b433398633 "2"^^ . _:b433398358 . _:b433398632 "2"^^ . _:b433399201 . _:b433398635 "2"^^ . _:b433397514 . _:b433398634 "2"^^ . _:b433398645 "2"^^ . _:b433398644 "2"^^ . . . _:b433398647 "2"^^ . . _:b433398848 . . _:b433398646 "2"^^ . _:b433397469 . _:b433398641 "2"^^ . _:b433397153 . _:b433398640 "2"^^ . _:b433397740 . _:b433398643 "2"^^ . _:b7741814 . _:b433398642 "2"^^ . . _:b433398653 "2"^^ . . _:b433398729 . _:b433398652 "2"^^ . _:b433398184 . . _:b433398655 "2"^^ . _:b433399101 . _:b433398654 "2"^^ . . _:b433398649 "2"^^ . _:b433398575 . _:b433398648 "2"^^ . _:b433398651 "2"^^ . _:b433397149 . _:b433398650 "2"^^ . _:b433398661 "2"^^ . _:b433398383 . _:b433397689 . _:b433398660 "2"^^ . _:b433399147 . . _:b433398663 "2"^^ . _:b433398662 "2"^^ . . _:b433399023 . _:b433398218 . _:b433398657 "2"^^ . . _:b433398656 "2"^^ . _:b433398659 "2"^^ . . _:b433398658 "2"^^ . _:b433398669 "2"^^ . _:b433398668 "2"^^ . _:b433398671 "2"^^ . . . _:b433398670 "2"^^ . _:b433398619 . _:b433398665 "2"^^ . . _:b433397272 . _:b433398664 "2"^^ . _:b433398667 "2"^^ . . _:b433398666 "2"^^ . _:b433397808 . _:b433398677 "2"^^ . _:b433398676 "2"^^ . . _:b433398679 "2"^^ . . _:b433398678 "2"^^ . _:b433397873 . _:b433398673 "2"^^ . _:b433398678 . _:b433398672 "2"^^ . _:b433398506 . _:b433398675 "2"^^ . _:b433397998 . _:b433398674 "2"^^ . _:b433398448 . _:b433398685 "2"^^ . _:b433398684 "2"^^ . _:b433398687 "2"^^ . . _:b433398686 "2"^^ . . . _:b433398681 "2"^^ . _:b433398680 "2"^^ . _:b433398683 "2"^^ . _:b433398682 "2"^^ . _:b433398693 "2"^^ . _:b433398692 "2"^^ . _:b433398695 "2"^^ . . _:b433399178 . _:b433397121 . _:b433398694 "2"^^ . _:b433398689 "2"^^ . . _:b433398688 "2"^^ . _:b433398691 "2"^^ . _:b433397108 . _:b433398690 "2"^^ . . . . _:b433398701 "2"^^ . _:b433398700 "2"^^ . _:b433398703 "2"^^ . _:b433398702 "2"^^ . _:b433398697 "2"^^ . _:b433399055 . _:b433398696 "2"^^ . _:b433398699 "2"^^ . _:b433397445 . _:b433398698 "2"^^ . _:b433399007 . _:b433398709 "2"^^ . _:b433398708 "2"^^ . . _:b433398711 "2"^^ . _:b433399509 . . . _:b433398710 "2"^^ . _:b433397921 . _:b433397315 . _:b433397476 . _:b433398705 "2"^^ . _:b433398704 "2"^^ . _:b433399208 . _:b433398707 "2"^^ . _:b433398317 . _:b433398706 "2"^^ . . _:b433399424 . _:b433398717 "2"^^ . . _:b433398716 "2"^^ . . _:b433398719 "2"^^ . _:b433398978 . _:b433398718 "2"^^ . . _:b433398713 "2"^^ . . _:b433398712 "2"^^ . . . _:b433398715 "2"^^ . _:b433398714 "2"^^ . _:b433398725 "2"^^ . . _:b433397559 . _:b433398724 "2"^^ . _:b433398727 "2"^^ . _:b433398726 "2"^^ . _:b433398721 "2"^^ . _:b433398721 . _:b433398720 "2"^^ . . _:b433398723 "2"^^ . _:b433398722 "2"^^ . _:b433397778 . _:b433398733 "2"^^ . . . _:b433398732 "2"^^ . . _:b433398779 . _:b433398735 "2"^^ . _:b433398734 "2"^^ . _:b433398729 "2"^^ . _:b433399465 . _:b433398728 "2"^^ . _:b433398731 "2"^^ . _:b433398730 "2"^^ . _:b433398008 . _:b433398741 "2"^^ . . _:b433398740 "2"^^ . . _:b433398743 "2"^^ . _:b433397772 . . _:b433398742 "2"^^ . . _:b433398737 "2"^^ . . _:b433398736 "2"^^ . _:b433398739 "2"^^ . . _:b433398738 "2"^^ . _:b433398749 "2"^^ . _:b433398748 "2"^^ . _:b433398648 . _:b433397421 . _:b433398751 "2"^^ . _:b433399328 . _:b433398750 "2"^^ . . . _:b433398745 "2"^^ . _:b433398744 "2"^^ . . _:b433398747 "2"^^ . . . _:b433398746 "2"^^ . . _:b433398757 "2"^^ . _:b433397694 . _:b433398756 "2"^^ . _:b433399135 . _:b433398759 "2"^^ . _:b433398758 "2"^^ . . _:b433398167 . . _:b433398753 "2"^^ . . . _:b433398752 "2"^^ . . _:b433398755 "2"^^ . _:b433398754 "2"^^ . . _:b433398798 . _:b433398765 "2"^^ . _:b433398764 "2"^^ . . _:b433397847 . _:b433398767 "2"^^ . _:b433397676 . _:b433398766 "2"^^ . _:b433398761 "2"^^ . _:b433398760 "2"^^ . _:b433399115 . _:b433398763 "2"^^ . . . _:b433398762 "2"^^ . . _:b433398773 "2"^^ . _:b433398050 . . . _:b433398772 "2"^^ . _:b433397606 . _:b433398775 "2"^^ . _:b433398774 "2"^^ . _:b433398769 "2"^^ . _:b433398768 "2"^^ . . _:b433398771 "2"^^ . _:b433398770 "2"^^ . _:b433398781 "2"^^ . . _:b433398780 "2"^^ . . . _:b433398783 "2"^^ . _:b433398283 . _:b433398782 "2"^^ . _:b433398777 "2"^^ . _:b433398620 . _:b433398980 . . _:b433398776 "2"^^ . _:b433398779 "2"^^ . . . _:b433398778 "2"^^ . . _:b433397230 . _:b433397765 "4"^^ . _:b433397764 "4"^^ . _:b433399200 . _:b433398268 . _:b433397767 "4"^^ . _:b433397766 "4"^^ . _:b7741817 "Notably, we and others have shown that antigen targeting to DNGR-1 is a useful strategy for inducing CTL responses and antibody responses in mice (Caminschi et al., >>2008<<; Sancho et al., 2008), and can additionally be used to generate Th1 and Th17 or for converting antigen-specific CD4+ T cells into regulatory T cells (Joffre et al., 2010)." . _:b433397761 "4"^^ . . . . _:b433397760 "4"^^ . . . _:b433397763 "4"^^ . _:b433397762 "4"^^ . _:b433397773 "4"^^ . _:b433397772 "4"^^ . _:b433397775 "4"^^ . _:b433397774 "4"^^ . _:b433397769 "4"^^ . _:b433397187 . _:b433397768 "4"^^ . . _:b433397771 "4"^^ . _:b433398867 . _:b433397925 . _:b433397770 "4"^^ . . _:b433397781 "4"^^ . . _:b433397780 "4"^^ . . _:b433398016 . _:b433397783 "4"^^ . _:b433397782 "4"^^ . . . _:b433397777 "4"^^ . . _:b433397776 "4"^^ . _:b433397918 . . _:b433397779 "4"^^ . . . _:b433397778 "4"^^ . _:b433399487 . _:b433398379 . _:b433397789 "4"^^ . _:b433397212 . . _:b433397116 . _:b433398314 . _:b433397788 "4"^^ . _:b433397811 . _:b433397791 "4"^^ . . _:b433397235 . _:b433397608 . . _:b433397817 . _:b433397790 "4"^^ . _:b433397785 "4"^^ . _:b433397269 . _:b433398363 . _:b433397784 "4"^^ . _:b433397787 "4"^^ . _:b433397786 "4"^^ . _:b433398828 . _:b433397797 "4"^^ . . _:b433397796 "4"^^ . _:b433397364 . _:b433397799 "4"^^ . _:b433397997 . _:b433397798 "4"^^ . _:b433397793 "4"^^ . _:b433397765 . _:b433399083 . _:b433397792 "4"^^ . _:b433397795 "4"^^ . _:b433397794 "4"^^ . _:b433397805 "4"^^ . . _:b433397582 . . _:b433397804 "4"^^ . _:b433397807 "4"^^ . _:b433397806 "4"^^ . _:b433399120 . _:b433397801 "4"^^ . _:b433397800 "4"^^ . . _:b433397803 "4"^^ . _:b433397802 "4"^^ . . _:b433397813 "4"^^ . . _:b433397812 "4"^^ . _:b433398564 . _:b433397688 . _:b433397815 "4"^^ . . _:b433397814 "4"^^ . _:b433399500 . _:b433398489 . _:b433397809 "4"^^ . _:b433397746 . _:b433397808 "4"^^ . _:b433397811 "4"^^ . . _:b433397810 "4"^^ . . . _:b433397821 "4"^^ . _:b433399518 . _:b433397820 "4"^^ . . _:b433397823 "4"^^ . _:b433397554 . _:b433397822 "4"^^ . . _:b433397817 "4"^^ . . . . _:b433398662 . _:b433397816 "4"^^ . . _:b433397819 "4"^^ . . . _:b433397818 "4"^^ . _:b433397185 . _:b433398819 . _:b433397829 "4"^^ . _:b433398579 . . . _:b433397828 "4"^^ . _:b433397831 "4"^^ . _:b433397946 . _:b433398926 . _:b433397830 "4"^^ . _:b433397825 "4"^^ . . . _:b433397824 "4"^^ . . . . _:b433397827 "4"^^ . . _:b433398170 . _:b433397826 "4"^^ . _:b433398762 . _:b433397837 "4"^^ . _:b433397836 "4"^^ . _:b433397839 "4"^^ . . _:b433397838 "4"^^ . _:b433397833 "4"^^ . _:b433397832 "4"^^ . . _:b433397661 . _:b433397835 "4"^^ . . _:b433397834 "4"^^ . _:b433397845 "3"^^ . _:b433397456 . . _:b433397844 "3"^^ . _:b433397847 "3"^^ . _:b433397846 "3"^^ . . _:b433397465 . _:b433397841 "4"^^ . _:b433398275 . _:b433397840 "4"^^ . _:b433397843 "3"^^ . _:b433398960 . _:b433397842 "4"^^ . _:b433397853 "3"^^ . . _:b433397852 "3"^^ . _:b433397855 "3"^^ . _:b433397854 "3"^^ . _:b433397849 "3"^^ . _:b433397885 . _:b433397848 "3"^^ . _:b433397851 "3"^^ . . _:b433397850 "3"^^ . . _:b433397314 . _:b433398239 . _:b433399327 . _:b433397861 "3"^^ . _:b433397438 . _:b433397860 "3"^^ . _:b433398705 . _:b433397863 "3"^^ . _:b433397627 . _:b433398598 . _:b433397862 "3"^^ . . _:b433397857 "3"^^ . _:b433397856 "3"^^ . _:b433399141 . _:b433397869 . _:b433397859 "3"^^ . _:b433397858 "3"^^ . _:b433397869 "3"^^ . _:b433397868 "3"^^ . _:b433397871 "3"^^ . _:b433398957 . . _:b433397870 "3"^^ . _:b433399191 . . _:b433397865 "3"^^ . _:b433397864 "3"^^ . _:b433398146 . _:b433397867 "3"^^ . _:b433397866 "3"^^ . _:b433397882 . _:b433398250 . _:b433397877 "3"^^ . . _:b433399213 . _:b433397876 "3"^^ . . _:b433397879 "3"^^ . _:b433397878 "3"^^ . _:b433397873 "3"^^ . _:b433397872 "3"^^ . _:b433398990 . _:b433397875 "3"^^ . _:b433397874 "3"^^ . _:b433397127 . _:b433397868 . . . _:b433397885 "3"^^ . . _:b433398741 . _:b433397884 "3"^^ . _:b433397887 "3"^^ . _:b433397886 "3"^^ . _:b433397881 "3"^^ . _:b433399378 . _:b433397880 "3"^^ . _:b433397883 "3"^^ . . _:b433397882 "3"^^ . _:b433397893 "3"^^ . _:b433397892 "3"^^ . . . _:b433397895 "3"^^ . _:b433397894 "3"^^ . _:b433397889 "3"^^ . _:b433397888 "3"^^ . _:b433398240 . _:b433397891 "3"^^ . _:b433397659 . _:b433397890 "3"^^ . . _:b433398485 . _:b433399426 . _:b433397901 "3"^^ . _:b433399460 . _:b433397900 "3"^^ . _:b433397903 "3"^^ . _:b433397655 . _:b433397902 "3"^^ . _:b433397640 . . . _:b433397897 "3"^^ . . _:b433397896 "3"^^ . _:b433397899 "3"^^ . _:b433397898 "3"^^ . . . _:b433397909 "3"^^ . _:b433397433 . _:b433397908 "3"^^ . . _:b433397379 . _:b433397911 "3"^^ . . _:b433397910 "3"^^ . . . _:b433397905 "3"^^ . _:b433397904 "3"^^ . . _:b433399184 . _:b433397907 "3"^^ . _:b433397629 . _:b433397906 "3"^^ . _:b433397630 . _:b433397917 "3"^^ . _:b433397916 "3"^^ . _:b7741803 "Analysis of leukocyte subsets in the mouse over the last 15 yr has highlighted the diversity of the DCs family and the notion that distinct DCs types perform different immune functions (Villadangos and Schnorrer, 2007; Naik, >>2008<<; Heath and Carbone, 2009; Merad and Manz, 2009)." . _:b433398945 . _:b433397919 "3"^^ . _:b433398301 . _:b433397918 "3"^^ . _:b433397913 "3"^^ . _:b433397912 "3"^^ . . _:b433397915 "3"^^ . _:b433397914 "3"^^ . _:b433397925 "3"^^ . . _:b433397924 "3"^^ . _:b433397913 . . _:b433398039 . _:b433397927 "3"^^ . _:b433397926 "3"^^ . _:b433398056 . . _:b433397921 "3"^^ . _:b433397920 "3"^^ . _:b433399011 . _:b433397923 "3"^^ . _:b433397922 "3"^^ . _:b433397933 "3"^^ . . _:b433397932 "3"^^ . _:b433397935 "3"^^ . _:b433398104 . _:b433397934 "3"^^ . . . _:b433397929 "3"^^ . _:b433398985 . _:b433397928 "3"^^ . _:b433398205 . _:b433398688 . _:b433397931 "3"^^ . _:b433397930 "3"^^ . _:b433397376 . _:b433397400 . _:b433397941 "3"^^ . _:b433397940 "3"^^ . _:b433397381 . _:b433397943 "3"^^ . _:b433397942 "3"^^ . _:b7741789 . _:b433399539 . . _:b433397937 "3"^^ . _:b433397612 . _:b433397936 "3"^^ . . _:b433397939 "3"^^ . _:b433397938 "3"^^ . _:b433399494 . _:b433397949 "3"^^ . _:b433397948 "3"^^ . _:b433397951 "3"^^ . _:b433397950 "3"^^ . _:b433397945 "3"^^ . _:b433397944 "3"^^ . _:b433397875 . _:b433397155 . _:b433397947 "3"^^ . . _:b433397946 "3"^^ . . _:b433397957 "3"^^ . _:b433397956 "3"^^ . _:b433397959 "3"^^ . . _:b433397958 "3"^^ . . _:b433397953 "3"^^ . _:b433397952 "3"^^ . _:b7741822 . _:b433397955 "3"^^ . . _:b433397954 "3"^^ . _:b433397965 "3"^^ . _:b433397964 "3"^^ . . _:b433397967 "3"^^ . _:b433398633 . _:b433397326 . _:b433397966 "3"^^ . . _:b433397961 "3"^^ . _:b433398736 . _:b433397960 "3"^^ . _:b433397963 "3"^^ . _:b433397962 "3"^^ . _:b433398530 . _:b433397973 "3"^^ . . _:b433397972 "3"^^ . _:b433397975 "3"^^ . . _:b433397974 "3"^^ . . _:b433397969 "3"^^ . _:b433397968 "3"^^ . . . _:b433397982 . _:b433397971 "3"^^ . _:b433397970 "3"^^ . _:b433398872 . _:b433397397 . . _:b433399105 . _:b433397981 "3"^^ . . _:b433397142 . _:b433399228 . _:b433397980 "3"^^ . _:b433399079 . _:b433397983 "3"^^ . _:b433397982 "3"^^ . _:b433397658 . . _:b433398158 . _:b433397977 "3"^^ . . _:b433397976 "3"^^ . . _:b433397979 "3"^^ . _:b433397978 "3"^^ . _:b433398057 . . _:b433398449 . _:b433397989 "3"^^ . _:b433399010 . . . _:b433397988 "3"^^ . _:b433397591 . _:b433397991 "3"^^ . _:b433397593 . . _:b433397990 "3"^^ . _:b433397580 . _:b433397985 "3"^^ . _:b433397656 . _:b433397984 "3"^^ . . _:b433397987 "3"^^ . . _:b433397986 "3"^^ . _:b433397997 "3"^^ . . _:b433397996 "3"^^ . . _:b433397999 "3"^^ . . . _:b433397998 "3"^^ . _:b433399411 . _:b433397993 "3"^^ . _:b433397992 "3"^^ . _:b433397995 "3"^^ . . _:b433397994 "3"^^ . _:b433398005 "3"^^ . . _:b433398004 "3"^^ . . _:b433398007 "3"^^ . _:b433397511 . _:b433398006 "3"^^ . . . _:b433398001 "3"^^ . . _:b433398000 "3"^^ . . . _:b433398003 "3"^^ . _:b433398002 "3"^^ . . _:b433398013 "3"^^ . _:b433398012 "3"^^ . _:b433398256 . _:b433398015 "3"^^ . _:b433398014 "3"^^ . _:b433398009 "3"^^ . _:b433398008 "3"^^ . _:b433398011 "3"^^ . _:b433398010 "3"^^ . _:b433399394 . _:b433397776 . _:b433398021 "3"^^ . _:b433397307 . _:b433398020 "3"^^ . _:b433398201 . _:b433398023 "3"^^ . _:b433398022 "3"^^ . _:b433398017 "3"^^ . . . _:b433398016 "3"^^ . _:b433398481 . . _:b433398019 "3"^^ . _:b433398018 "3"^^ . _:b433398029 "3"^^ . . . _:b433398028 "3"^^ . _:b433397652 . _:b433398031 "3"^^ . _:b433398471 . _:b433398030 "3"^^ . _:b433399094 . _:b433398025 "3"^^ . . _:b433398024 "3"^^ . . . _:b433398027 "3"^^ . . _:b433398811 . . . _:b433399192 . _:b433398026 "3"^^ . _:b433398037 "3"^^ . _:b433398036 "3"^^ . _:b433398039 "3"^^ . _:b433398881 . _:b433398038 "3"^^ . _:b433398033 "3"^^ . _:b433398032 "3"^^ . _:b433398035 "3"^^ . . _:b433398122 . _:b433398034 "3"^^ . _:b433398380 . . _:b433398221 . _:b433398045 "3"^^ . _:b433398044 "3"^^ . . _:b433399215 . _:b433398047 "3"^^ . . _:b433398046 "3"^^ . _:b433398838 . _:b433398041 "3"^^ . _:b433398040 "3"^^ . . _:b433398043 "3"^^ . _:b433398042 "3"^^ . _:b433399223 . _:b433398053 "3"^^ . _:b433399359 . _:b433398052 "3"^^ . _:b433398055 "3"^^ . _:b433397474 . _:b433398054 "3"^^ . _:b433397637 . _:b433398626 . _:b433398049 "3"^^ . _:b433398943 . . _:b433398048 "3"^^ . _:b433397377 . _:b433398051 "3"^^ . . . _:b433398050 "3"^^ . _:b433398061 "3"^^ . _:b433397410 . _:b433398060 "3"^^ . . _:b433398063 "3"^^ . _:b433398851 . . _:b433398062 "3"^^ . _:b433397636 . _:b433398057 "3"^^ . . _:b433398056 "3"^^ . _:b433398059 "3"^^ . _:b433398058 "3"^^ . _:b433398069 "3"^^ . _:b433398068 "3"^^ . _:b433398071 "3"^^ . _:b433398070 "3"^^ . _:b433399419 . . _:b433399183 . _:b433398065 "3"^^ . _:b433398064 "3"^^ . _:b433398338 . . _:b433397505 . _:b433398067 "3"^^ . . . _:b433398066 "3"^^ . _:b433398077 "3"^^ . _:b433398962 . . . _:b433398076 "3"^^ . _:b433398716 . . _:b433398079 "3"^^ . _:b433398602 . _:b7741814 "BDCA3+ DCs have been previously reported in human spleen (Vel\u00E1squez-Lopera et al., 2008) and in the spleen and bone marrow of humanized mice (Cravens et al., >>2005<<), but it is not clear whether they precisely correspond to the DNGR-1+ BDCA3hi population characterized here." . _:b433398078 "3"^^ . . _:b433398073 "3"^^ . . _:b433398072 "3"^^ . . _:b433398075 "3"^^ . _:b433397336 . _:b433398074 "3"^^ . _:b433398759 . _:b433398085 "3"^^ . _:b433399544 . _:b7741789 "4), consistent with data in the mouse (Schiavoni et al., >>2002<<). In contrast, the same pDCs did not express Necl2 or DNGR-1 (Fig." . _:b433398084 "3"^^ . . _:b433398089 . _:b433398087 "3"^^ . _:b433398086 "3"^^ . _:b433398998 . _:b433397394 . _:b433398081 "3"^^ . _:b433398080 "3"^^ . _:b433399251 . . _:b433399546 . _:b433398083 "3"^^ . . _:b433398082 "3"^^ . . _:b433398093 "3"^^ . . _:b433397614 . _:b433399033 . _:b433398092 "3"^^ . _:b433398095 "3"^^ . . _:b433397290 . _:b433398094 "3"^^ . . _:b433398089 "3"^^ . _:b433397749 . . . _:b433398088 "3"^^ . _:b433398091 "3"^^ . _:b433398090 "3"^^ . _:b433398101 "3"^^ . _:b433397402 . _:b433398100 "3"^^ . . _:b433397610 . _:b433398103 "3"^^ . _:b433397976 . _:b433398102 "3"^^ . _:b433397515 . _:b433398410 . _:b433398097 "3"^^ . . _:b433398096 "3"^^ . _:b433399511 . _:b433398099 "3"^^ . . _:b433398551 . _:b433398098 "3"^^ . _:b433397170 . _:b433397698 . _:b433398109 "3"^^ . . _:b433398108 "3"^^ . _:b433398111 "3"^^ . _:b433397706 . _:b433398454 . _:b433398110 "3"^^ . _:b433398105 "3"^^ . _:b433398104 "3"^^ . _:b433398107 "3"^^ . _:b433398106 "3"^^ . _:b433398288 . . . _:b433399392 . . _:b433398117 "3"^^ . _:b433397631 . _:b433399285 . . _:b433398116 "3"^^ . . _:b433398119 "3"^^ . _:b433398118 "3"^^ . _:b433398113 "3"^^ . _:b7741832 . _:b433398112 "3"^^ . _:b433398115 "3"^^ . _:b433398114 "3"^^ . _:b433397970 . _:b433398125 "3"^^ . _:b433398531 . _:b433398124 "3"^^ . . _:b433397500 . _:b433398127 "3"^^ . _:b433398126 "3"^^ . . . _:b433398121 "3"^^ . _:b433398120 "3"^^ . _:b433398123 "3"^^ . . _:b433398122 "3"^^ . _:b433398133 "3"^^ . . _:b433397405 . _:b433398132 "3"^^ . _:b433399464 . _:b433398135 "3"^^ . _:b433398134 "3"^^ . _:b433398129 "3"^^ . _:b433398128 "3"^^ . _:b433398131 "3"^^ . _:b433398130 "3"^^ . _:b433398141 "3"^^ . _:b433398140 "3"^^ . _:b433398143 "3"^^ . _:b433399386 . _:b433398142 "3"^^ . _:b433398137 "3"^^ . _:b433398720 . _:b433398658 . _:b433398136 "3"^^ . _:b433398139 "3"^^ . . _:b433398138 "3"^^ . _:b433398464 . _:b433398149 "3"^^ . _:b433398148 "3"^^ . . _:b433399001 . . _:b433398151 "3"^^ . . _:b433398150 "3"^^ . _:b433397164 . _:b433398145 "3"^^ . _:b433397300 . _:b433398144 "3"^^ . _:b433398147 "3"^^ . . _:b433398146 "3"^^ . _:b433398157 "3"^^ . . _:b433398482 . _:b433398156 "3"^^ . _:b433398159 "3"^^ . . _:b433398158 "3"^^ . _:b433398153 "3"^^ . . _:b433398152 "3"^^ . _:b433398155 "3"^^ . _:b433399406 . _:b433398154 "3"^^ . . _:b433398165 "3"^^ . . . _:b433397671 . _:b433398164 "3"^^ . . _:b433398253 . _:b433398167 "3"^^ . _:b433398983 . _:b433398166 "3"^^ . _:b433397114 . _:b433398161 "3"^^ . _:b433398160 "3"^^ . . _:b433398163 "3"^^ . . _:b433398286 . _:b433398162 "3"^^ . _:b433399357 . . _:b433398173 "3"^^ . _:b433398172 "3"^^ . _:b433398175 "3"^^ . _:b433399474 . _:b433399227 . _:b433398174 "3"^^ . _:b433399480 . _:b433398169 "3"^^ . _:b433399015 . _:b433398168 "3"^^ . _:b433398171 "3"^^ . _:b433397713 . _:b433398170 "3"^^ . . _:b433398181 "3"^^ . _:b433398180 "3"^^ . . . _:b433398183 "3"^^ . _:b433397332 . . _:b433398182 "3"^^ . _:b433398177 "3"^^ . _:b433398176 "3"^^ . _:b433398179 "3"^^ . . _:b433398178 "3"^^ . _:b433397542 . _:b433398189 "3"^^ . _:b433398188 "3"^^ . _:b433398191 "3"^^ . _:b433398431 . _:b7741808 "Our ability to detect DNGR-1+ BDCA3hi DCs in human spleen cell suspensions is unlikely to be explained by blood contamination as DNGR-1+ BDCA3hi DCs represent 0.05% of PBMC (Caminschi et al., 2008; Huysamen et al., >>2008<<; Sancho et al., 2008), yet make up 0.1% of total splenocytes (Table S1)." . . . _:b433398190 "3"^^ . _:b433398185 "3"^^ . _:b433397977 . _:b433398184 "3"^^ . _:b433397760 . _:b433398187 "3"^^ . _:b433398186 "3"^^ . _:b433398080 . _:b433399078 . _:b433398197 "3"^^ . _:b433398750 . _:b433398196 "3"^^ . _:b433398623 . _:b433398199 "3"^^ . _:b433398198 "3"^^ . _:b433398193 "3"^^ . _:b433398192 "3"^^ . . _:b433398195 "3"^^ . _:b433398194 "3"^^ . . _:b433398205 "3"^^ . _:b433398204 "3"^^ . _:b433398207 "3"^^ . _:b433398206 "3"^^ . _:b433398201 "3"^^ . _:b433397802 . _:b433398200 "3"^^ . . . _:b433398203 "3"^^ . . . _:b433398202 "3"^^ . _:b433398213 "3"^^ . . _:b433398212 "3"^^ . . _:b433398215 "3"^^ . _:b433398214 "3"^^ . _:b433398209 "3"^^ . _:b433398412 . _:b433397275 . . _:b433398208 "3"^^ . _:b433398211 "3"^^ . _:b433398210 "3"^^ . _:b433399337 . _:b433397454 . _:b433398221 "3"^^ . _:b433398937 . _:b433398856 . _:b433397101 . _:b433398220 "3"^^ . _:b433398223 "3"^^ . . _:b433398222 "3"^^ . _:b433398217 "3"^^ . . _:b433398216 "3"^^ . . . _:b433398681 . _:b433398219 "3"^^ . . _:b433398218 "3"^^ . . _:b433398229 "3"^^ . . _:b433397499 . _:b433398228 "3"^^ . _:b433398231 "3"^^ . . _:b433398230 "3"^^ . . . . _:b433398225 "3"^^ . . _:b433397193 . _:b433398224 "3"^^ . _:b433398092 . _:b433398227 "3"^^ . _:b433398791 . _:b433397750 . _:b433399379 . _:b433397363 . _:b433398226 "3"^^ . _:b433398237 "3"^^ . _:b433399470 . _:b433398236 "3"^^ . . _:b433398239 "3"^^ . _:b433398689 . _:b433398238 "3"^^ . _:b433399439 . _:b433398233 "3"^^ . . _:b433398232 "3"^^ . _:b433398235 "3"^^ . . _:b433399077 . _:b433398874 . _:b433398234 "3"^^ . _:b433398245 "3"^^ . . _:b433398244 "3"^^ . _:b433397539 . _:b433398247 "3"^^ . . . _:b433398246 "3"^^ . . _:b433397138 . _:b433398241 "3"^^ . _:b433399114 . _:b433398240 "3"^^ . . _:b433398243 "3"^^ . _:b433398242 "3"^^ . . . _:b433398253 "3"^^ . _:b433398121 . _:b433398252 "3"^^ . _:b433397941 . _:b433399071 . . _:b433398255 "3"^^ . _:b433398254 "3"^^ . _:b433398312 . _:b433397557 . _:b433397191 . . _:b433397625 . _:b433398249 "3"^^ . _:b433397512 . _:b433399255 . _:b433397303 . _:b433398248 "3"^^ . _:b433398251 "3"^^ . _:b433398250 "3"^^ . _:b433399318 . . _:b433398261 "3"^^ . _:b433398492 . _:b433398260 "3"^^ . _:b433398263 "3"^^ . _:b433398262 "3"^^ . _:b433398797 . _:b433398257 "3"^^ . _:b433397404 . _:b433399174 . _:b433398256 "3"^^ . _:b433398259 "3"^^ . _:b433398258 "3"^^ . _:b433398478 . _:b433398269 "3"^^ . _:b433398268 "3"^^ . _:b433398271 "3"^^ . _:b433397298 . _:b433398079 . _:b433398270 "3"^^ . . _:b433398265 "3"^^ . _:b433398264 "3"^^ . _:b433397924 . . _:b433398267 "3"^^ . _:b433398324 . _:b433398266 "3"^^ . _:b433398863 . _:b433398745 . . . . . . _:b433399021 . . . . . _:b433399529 . _:b433398657 . . _:b433399144 . . _:b433399051 . . _:b433399026 . _:b433398396 . . _:b433399235 . . _:b433397727 . . _:b433397887 . _:b433399538 . _:b433398731 . _:b433398756 . . . _:b433398909 . _:b433397281 . . _:b433398210 . . _:b433398501 . _:b433397134 . _:b433397842 . _:b433399433 . _:b433397424 . . . _:b433397528 . . . _:b433398166 . _:b433397955 . _:b433397408 . _:b433397415 . _:b433399232 . _:b433399076 . _:b433397919 . . . _:b433398936 . _:b433397359 . . . . _:b433398528 . _:b433399445 . _:b433398036 . _:b433398591 . _:b433397741 . _:b433399354 . _:b433397536 . . _:b433397654 . . _:b433398304 . . . . . _:b433397805 . _:b433398768 . . . . _:b433397350 . _:b433398888 . . _:b433398584 . . _:b433397501 . . . . . . _:b433397825 . _:b433397907 . _:b433397523 . _:b433397682 . _:b433397338 . . _:b7741783 "Flt3L was included in the differentiation \u201Ccocktail\u201D because BDCA3+ DCs are expanded in Flt3L-treated human subjects (Galibert et al., >>2005<<), and Flt3L is essential for mouse DCs development (Merad and Manz, 2009)." . . . . _:b433398942 . . . _:b433397126 . _:b433399127 . . _:b433398438 . . _:b7741828 . . _:b433397222 . _:b433399264 . _:b433398824 . . _:b433399291 . . . _:b433398679 . . . _:b433399446 . . . . _:b433398541 . . . . . _:b433397100 . _:b433397101 . _:b433397102 . _:b433397103 . _:b433398323 . . _:b433397098 . _:b433397099 . _:b433399128 . . _:b433397116 . _:b433397117 . _:b433397118 . _:b433397119 . _:b433397112 . _:b433398823 . _:b433397113 . _:b433397114 . _:b433397115 . _:b433398120 . _:b433397108 . _:b433397109 . _:b433397110 . . _:b433397111 . _:b433397104 . _:b433397105 . _:b433399420 . _:b433397106 . . _:b433397107 . _:b433397482 . . _:b433398860 . _:b433397616 . . . . . _:b433398905 . _:b433397965 . _:b433397704 . _:b433398507 . _:b433398319 . _:b433398131 . _:b433397165 . _:b433398674 . _:b433397565 . _:b433397447 . _:b433397368 . _:b433398815 . . . . _:b433397228 . _:b433397229 . . _:b433399350 . _:b433397230 . _:b433397986 . _:b433397231 . _:b433398395 . _:b433398133 . _:b433397224 . . _:b433397225 . _:b433397226 . _:b433397227 . _:b433397154 . _:b433397220 . _:b433397221 . _:b433397222 . _:b433397223 . _:b433397216 . _:b433397263 . _:b433397217 . _:b433397218 . _:b433397219 . _:b433397244 . . _:b433397245 . _:b433397246 . _:b433397247 . _:b433397240 . _:b433399070 . _:b433397241 . _:b433397242 . _:b433397243 . _:b433397236 . _:b433397237 . _:b433397238 . _:b433397239 . _:b433397232 . . _:b433398293 . _:b433397233 . _:b433397234 . _:b433397981 . _:b433397235 . _:b433398582 . _:b433397196 . _:b433397197 . _:b433397198 . _:b433397199 . _:b433397192 . _:b433397193 . _:b433397194 . _:b433397195 . _:b433397188 . _:b433397189 . _:b433397190 . _:b433397191 . _:b7741829 . _:b433397184 . _:b433397185 . _:b433397186 . . _:b433397187 . _:b433397212 . . _:b433397213 . _:b433397214 . _:b433399428 . _:b433397215 . _:b433397208 . _:b433397209 . _:b433397210 . _:b433397211 . . _:b433397204 . _:b433397205 . _:b433397206 . _:b433397207 . _:b433397200 . _:b433397201 . _:b433397202 . _:b433397203 . _:b433397164 . _:b433397165 . _:b433397166 . _:b433397167 . _:b433397160 . _:b433397161 . _:b433398216 . _:b433397162 . _:b433397163 . _:b433399046 . _:b433397156 . _:b433397157 . _:b433397158 . _:b433397159 . _:b433397398 . _:b433397152 . _:b433398051 . _:b433397153 . _:b433397154 . . _:b433397155 . _:b433399417 . _:b433397180 . _:b433397181 . _:b433398418 . _:b433397182 . _:b433397151 . _:b433397183 . . _:b433397176 . _:b433397177 . _:b433398334 . _:b433397178 . _:b433397179 . _:b433397172 . _:b433397173 . _:b433397174 . _:b433397175 . _:b433397168 . _:b433397169 . _:b433399250 . _:b433397170 . _:b433397171 . _:b433397132 . _:b433397133 . _:b433399231 . _:b433397134 . _:b433397135 . _:b433397128 . _:b433397129 . _:b433397130 . _:b433397131 . _:b433398820 . _:b433397124 . _:b433397125 . . _:b433397126 . . _:b433397127 . _:b433397120 . . _:b433397121 . . _:b433397122 . _:b433397123 . _:b433397148 . _:b433397149 . _:b433397150 . _:b433397151 . _:b433397144 . _:b433399407 . _:b433397145 . _:b433397146 . . _:b433397147 . _:b433397790 . _:b433397140 . _:b433397624 . _:b433399166 . _:b433397141 . _:b433397142 . _:b433397143 . _:b433397136 . _:b433397137 . _:b433397138 . . _:b433397139 . _:b433398788 . _:b7741787 . . _:b433398350 . . . _:b433399194 . _:b433398295 . _:b433397362 . _:b433397254 . _:b433397207 . _:b433398789 . _:b433399367 . . . _:b433397409 . _:b433398732 . . _:b433399054 . . . . . _:b433398585 . . _:b433397901 . . . _:b433397510 . . . . . _:b433398284 . _:b433398440 . _:b433398072 . . _:b433398940 . . . _:b7741815 . . _:b433398243 . . . _:b433397989 . . _:b433397280 . . _:b433397441 . . . . . . . _:b433397428 . . . . _:b433398326 . _:b433399066 . . . _:b433397806 . . _:b433397612 . _:b433397613 . _:b433397614 . _:b433397615 . . _:b433397608 . . _:b433397609 . _:b433397610 . . _:b433397611 . _:b433397604 . _:b433398559 . _:b433397605 . _:b433397606 . _:b433397607 . _:b433397600 . _:b433398309 . _:b433397601 . _:b433397602 . _:b433397603 . _:b433397628 . _:b433397629 . _:b433397630 . _:b433397631 . _:b433397624 . _:b433397625 . _:b433397626 . . _:b433397627 . . _:b433397620 . _:b433397621 . _:b433397622 . . _:b433397623 . _:b433397616 . _:b433397617 . _:b433397618 . _:b433397619 . . _:b433397580 . . _:b433397581 . _:b433397582 . _:b433397583 . _:b433397576 . _:b433397577 . _:b433397578 . _:b433397579 . _:b433397572 . _:b433397354 . _:b433397573 . _:b433397574 . _:b433397575 . _:b433397568 . _:b433397569 . _:b433397570 . _:b433397571 . _:b433397596 . _:b433397597 . _:b433397598 . _:b433397599 . _:b433397592 . _:b433397593 . _:b433397594 . _:b433398958 . _:b433397595 . _:b433397588 . _:b433397589 . . _:b433397590 . _:b433397591 . . _:b433397584 . _:b433397585 . _:b433397586 . _:b433397587 . _:b433397548 . _:b433397549 . . _:b433397550 . _:b433397551 . _:b433397544 . _:b433397545 . _:b433397870 . . _:b433398463 . _:b433397546 . _:b433397547 . _:b433397540 . _:b433399197 . _:b433397541 . _:b433397542 . . _:b433397543 . _:b433397536 . _:b433397537 . _:b433397538 . _:b433398686 . _:b433397539 . _:b433398289 . _:b433397564 . _:b433397565 . . . _:b433397566 . _:b433397567 . _:b433397560 . _:b433397561 . _:b433397562 . _:b433397563 . _:b433397556 . _:b433397557 . _:b433397558 . _:b433397559 . _:b433397552 . _:b433397553 . _:b433397554 . _:b433397555 . _:b433397516 . . . _:b433397617 . _:b433397517 . _:b433397518 . _:b433397519 . _:b433397512 . _:b433397513 . _:b433397514 . _:b433397515 . _:b433397508 . . _:b433397509 . _:b433397510 . _:b433397511 . _:b433397504 . _:b433397505 . _:b433397916 . _:b433397506 . _:b433397507 . _:b433397532 . _:b433397533 . _:b433397534 . _:b433397535 . _:b433397528 . _:b433397529 . _:b433397530 . _:b433397531 . _:b433397524 . _:b433397525 . _:b433397526 . _:b433397527 . _:b433397520 . _:b433397521 . _:b433397522 . _:b433397523 . _:b433397740 . _:b433397741 . _:b433397742 . _:b433397743 . _:b433397736 . _:b433397737 . _:b433397738 . _:b433397739 . _:b433398777 . _:b433397732 . _:b433397733 . _:b433397734 . _:b433397735 . _:b433397728 . . _:b433397729 . _:b433397730 . _:b433397731 . _:b433397756 . _:b433397757 . . _:b433397758 . _:b433397759 . _:b433397752 . _:b433397753 . _:b433397754 . _:b433397755 . _:b433397748 . _:b433397749 . _:b433397750 . _:b433397751 . _:b433397744 . _:b433397745 . _:b433397746 . _:b433397747 . _:b433397325 . _:b433397708 . _:b433397709 . _:b433397710 . _:b433397711 . _:b433397704 . _:b433397705 . _:b433399430 . _:b433397706 . _:b433397707 . _:b433397700 . _:b433397701 . _:b433397702 . . _:b433397703 . _:b433397696 . _:b433397697 . _:b433397698 . . _:b433397699 . _:b433397724 . _:b433397725 . _:b433398416 . _:b433397726 . _:b433397727 . _:b433397720 . _:b433399287 . _:b433397721 . _:b433397722 . _:b433397723 . _:b433397716 . _:b433397717 . _:b433397718 . _:b433397719 . _:b433397712 . _:b433397713 . _:b433397714 . _:b433397715 . _:b433397676 . _:b433397677 . _:b433397201 . _:b433397678 . _:b433397679 . _:b433397672 . _:b433397673 . _:b433397674 . _:b433397675 . _:b433397668 . _:b433398516 . _:b433397669 . _:b433397670 . _:b433397671 . _:b433397664 . _:b433397176 . . . _:b433397665 . _:b433399450 . _:b433397444 . . _:b433397666 . _:b433397667 . _:b433397692 . _:b433397693 . . _:b433397694 . _:b433397695 . _:b433397688 . _:b433397689 . _:b433397690 . _:b433397691 . _:b433397684 . _:b433397685 . _:b433397686 . . _:b433397687 . _:b433397680 . _:b433397681 . _:b433397682 . _:b433397683 . _:b433397644 . _:b433397645 . _:b433397646 . _:b433397647 . _:b433399320 . _:b433397640 . . _:b433397641 . _:b433397642 . _:b433397643 . _:b433397636 . _:b433397637 . _:b433397638 . _:b433397639 . _:b433397632 . _:b433397633 . _:b433397634 . _:b433397635 . . _:b433397660 . _:b433397661 . _:b433397662 . _:b433397663 . _:b433397656 . _:b433397657 . _:b433399188 . _:b433397658 . _:b433397659 . _:b433397652 . _:b433397653 . _:b433397654 . _:b433397655 . _:b433397648 . _:b433397649 . . _:b433397650 . _:b433397651 . _:b433397356 . _:b433398316 . . _:b433397357 . _:b433397358 . _:b433397359 . . _:b433397352 . _:b433397353 . _:b433397354 . _:b433397355 . _:b433397568 . _:b433397348 . . _:b433397349 . _:b433397350 . _:b433397351 . _:b433397344 . _:b433397345 . _:b433397346 . . _:b433397347 . _:b433397372 . _:b433397373 . _:b433397374 . _:b433397375 . _:b433397368 . _:b433397369 . _:b433398172 . _:b433397370 . _:b433397371 . _:b433397364 . _:b433398272 . _:b433397365 . _:b433397366 . _:b433397367 . _:b433397360 . _:b433398226 . _:b433397361 . _:b433397362 . _:b433397363 . _:b433397324 . _:b433397325 . _:b433397326 . . _:b433397255 . _:b433397327 . _:b433397320 . _:b433397321 . _:b7741807 "Our ability to detect DNGR-1+ BDCA3hi DCs in human spleen cell suspensions is unlikely to be explained by blood contamination as DNGR-1+ BDCA3hi DCs represent 0.05% of PBMC (Caminschi et al., >>2008<<; Huysamen et al., 2008; Sancho et al., 2008), yet make up 0.1% of total splenocytes (Table S1)." . _:b433397322 . . _:b433398552 . _:b433397323 . _:b433397316 . _:b433397317 . _:b433397318 . _:b433397319 . _:b433397312 . _:b433397313 . _:b433397314 . _:b433397315 . _:b433397340 . _:b433398486 . _:b433397341 . _:b433397342 . _:b433397343 . _:b433397336 . _:b433398277 . _:b433397337 . _:b433397338 . _:b433397339 . _:b433397332 . _:b433397333 . _:b433397334 . . _:b433397335 . _:b433397328 . _:b433397329 . _:b433398269 . _:b433397330 . _:b433397331 . _:b433397292 . _:b433397293 . _:b433397294 . _:b433397295 . _:b433397288 . . _:b433399260 . _:b433397289 . _:b433397290 . . _:b433397291 . _:b433397284 . _:b433397285 . _:b433397286 . _:b433397287 . _:b433397280 . . _:b433397281 . _:b433397282 . _:b433397283 . _:b433397308 . _:b433397309 . _:b433397310 . _:b433397311 . . _:b433397304 . _:b433397305 . _:b433397306 . _:b433397307 . _:b433397300 . _:b433397144 . _:b433397301 . _:b433397302 . _:b433397303 . _:b433397296 . _:b433397297 . _:b7741788 "They also did not express high levels of EpCam, indicating that they were not Langerhans cells (Bursch et al., >>2007<<). Finally, CB-derived DNGR-1+ BDCA3+ DCs appeared to be immature, in that they did not express CD40, CD83, or CCR7 (Fig. 3 D). Consistent with immaturity, DNGR-1+ BDCA3+ DCs were not noticeably dendritic until the CBDC cultures were" . _:b433397298 . _:b433397538 . _:b433397299 . _:b433397260 . . _:b433397261 . _:b433397262 . _:b433397263 . _:b433397256 . _:b433397257 . _:b433397258 . _:b433399168 . _:b433397259 . _:b433397252 . _:b433397253 . _:b433397254 . _:b433397255 . _:b433398831 . _:b433397248 . _:b433397249 . _:b433397250 . _:b433397251 . _:b433397276 . _:b433397277 . _:b433397278 . . . _:b433397279 . _:b433397272 . _:b433397273 . _:b433397274 . _:b433397275 . _:b433397268 . _:b433397269 . _:b433397270 . _:b433397271 . _:b433398127 . _:b433397264 . _:b433397265 . _:b433399472 . _:b433397306 . _:b433397266 . _:b433397267 . _:b433397484 . _:b433397485 . _:b433398577 . _:b433397486 . _:b433397487 . _:b433397480 . _:b433397481 . . _:b433397482 . _:b433398566 . _:b433397483 . _:b433397476 . _:b433397477 . _:b433397478 . _:b433397479 . _:b433397472 . _:b433397473 . _:b433397474 . _:b433397649 . _:b433397475 . _:b433397500 . _:b433397501 . _:b433397502 . _:b433397503 . _:b433397496 . _:b433397497 . _:b433397498 . _:b433397499 . _:b433397492 . _:b433397493 . _:b433397494 . _:b433397495 . _:b433397488 . _:b433397489 . _:b433398904 . _:b433397490 . _:b433397491 . _:b433397452 . _:b433397453 . _:b433397454 . _:b433397455 . _:b433397448 . _:b433397449 . _:b433398701 . _:b433397450 . _:b433397451 . _:b433397444 . _:b433397445 . _:b433397446 . _:b433398020 . _:b433397447 . _:b433397440 . _:b433397441 . _:b433397442 . _:b433397443 . _:b433397468 . _:b433397469 . _:b433397470 . _:b433397471 . _:b433397464 . _:b433397465 . _:b433397466 . . _:b433397467 . _:b433397460 . _:b433397461 . _:b433397462 . _:b433397463 . _:b433397456 . _:b433397457 . _:b433397458 . _:b433398372 . _:b433397459 . _:b433397420 . _:b433397421 . _:b433397462 . _:b433397422 . . _:b433397423 . _:b433397416 . _:b433397417 . _:b433397418 . _:b433397419 . _:b433397412 . _:b433397497 . _:b433397413 . _:b433397414 . _:b433397415 . _:b433397408 . _:b433397409 . . _:b433397410 . _:b433397411 . _:b433397436 . _:b433397437 . _:b433397438 . _:b433397439 . _:b433397432 . _:b433397433 . . _:b433397434 . . _:b433397435 . _:b433397428 . _:b433397429 . _:b433397430 . _:b433397431 . _:b433397424 . _:b433397425 . _:b433397426 . _:b433397427 . _:b433397388 . _:b433397389 . _:b433397390 . _:b433397391 . _:b7741816 . _:b433397384 . _:b433397385 . _:b433397386 . _:b433397387 . _:b433397215 . _:b433397380 . _:b433397381 . _:b433397382 . _:b433397383 . _:b433397376 . _:b433398439 . _:b433397377 . _:b433397378 . _:b433397379 . _:b433397404 . _:b433397405 . _:b433397406 . _:b433397407 . _:b433397400 . _:b433397401 . _:b433397402 . _:b433397403 . _:b433397396 . _:b433398581 . _:b433397397 . _:b433397398 . _:b433397399 . _:b433397392 . _:b433397393 . _:b433397394 . _:b433397395 . . _:b433397562 . _:b7741827 . _:b433397939 . _:b433397677 . . _:b433397286 . . _:b433398673 . _:b433397274 . _:b433398562 . _:b433399202 . _:b433398252 . _:b433398154 . . _:b433399173 . . _:b433399530 . . _:b433397340 .