_:b441737028 . _:b441736915 "5"^^ . . _:b441736914 "5"^^ . . . _:b441736925 "5"^^ . . _:b441736910 . . _:b441736924 "5"^^ . _:b441736927 "5"^^ . . _:b441736940 . _:b441736926 "5"^^ . . _:b441736921 "5"^^ . _:b441737360 . _:b441736920 "5"^^ . . . . _:b441736923 "5"^^ . . _:b441736922 "5"^^ . _:b8585411 "It was found that the efficacy of this treatment is hampered by the highly immunosuppressive environment in mesothelioma [>>25<<]. Adjacent to this, it was found that COX-2 over-expression in mesothelioma correlates with poor prognosis [26]. Combining the current knowledge on MDSC, COX-2 over-expression and immune suppression, we aimed to determine the effect of" . . _:b441737363 . _:b441736933 "5"^^ . . _:b441736932 "5"^^ . _:b441736935 "5"^^ . _:b441737748 . _:b441737558 . _:b441737712 . . _:b441737187 . _:b441736934 "5"^^ . _:b441736929 "5"^^ . _:b441737437 . _:b441736928 "5"^^ . _:b441736931 "5"^^ . . _:b441736930 "5"^^ . _:b441737384 . _:b441736877 . . _:b441736941 "5"^^ . _:b441737229 . _:b441737429 . _:b441737561 . _:b441736940 "5"^^ . . . _:b441737358 . _:b441736943 "5"^^ . _:b8585407 . _:b441736757 . _:b441737353 . . _:b441736942 "5"^^ . . _:b441736756 . _:b441736937 "5"^^ . . _:b441736759 . . _:b441736936 "5"^^ . _:b441737732 . _:b441736758 . . _:b441736939 "5"^^ . _:b441736753 . _:b441736938 "5"^^ . _:b441736949 "4"^^ . _:b441736752 . _:b441737480 . . _:b441736948 "4"^^ . . _:b441736755 . . _:b441737446 . _:b441736951 "4"^^ . _:b441736754 . . . _:b441736950 "4"^^ . _:b441736765 . . _:b441737375 . _:b441736764 . _:b441736945 "5"^^ . . . _:b441736767 . . _:b441736809 . _:b441736944 "5"^^ . . . _:b441736947 "4"^^ . _:b441736766 . . . _:b441736946 "4"^^ . _:b441736761 . . _:b441736957 "4"^^ . _:b441736760 . _:b441736956 "4"^^ . _:b441736763 . _:b441737034 . _:b441737691 . _:b441736959 "4"^^ . _:b441737378 . _:b441736762 . _:b8585407 . _:b441736958 "4"^^ . _:b441736773 . _:b441737295 . _:b8585368 . _:b441736953 "4"^^ . _:b8585399 . _:b441736772 . . _:b441737003 . _:b441736952 "4"^^ . _:b441736775 . . . _:b441736955 "4"^^ . _:b441736774 . _:b441736954 "4"^^ . _:b441736769 . _:b441736959 . . _:b441736965 "4"^^ . _:b441736768 . _:b8585383 . _:b441736964 "4"^^ . _:b441737747 . _:b441736771 . _:b441737579 . _:b441736967 "4"^^ . _:b441736770 . . _:b441736966 "4"^^ . . _:b441736781 . . _:b441736970 . _:b441736961 "4"^^ . _:b441736780 . _:b441737518 . _:b8585379 . _:b441736960 "4"^^ . _:b441737350 . _:b441736783 . _:b441737670 . _:b441736963 "4"^^ . _:b441737281 . _:b441736782 . _:b441736962 "4"^^ . _:b441736777 . . _:b441736973 "4"^^ . _:b441736776 . _:b441737703 . _:b441736972 "4"^^ . . _:b441737317 . . _:b441736779 . _:b441736975 "4"^^ . _:b441736778 . . _:b441736974 "4"^^ . _:b441736789 . _:b441737013 . _:b441736969 "4"^^ . _:b441736788 . _:b441736968 "4"^^ . _:b441736791 . . _:b441737330 . . _:b441736971 "4"^^ . _:b441736942 . _:b441736790 . _:b441736970 "4"^^ . _:b441737571 . _:b441737268 . _:b441736785 . _:b8585371 "More recently, it has been shown that macrophages can be derived from MDSC [6,>>29<<]. Therefore this cell population was also analyzed. Macrophages were characterized by FACS based on their FSC/SSC, in combination with the expression of CD11b, F4/80 and MHCII on their membrane. A significant reduction in macrophages was" . _:b441737502 . _:b441736981 "4"^^ . _:b441736784 . _:b441737339 . . _:b441737684 . . _:b441736980 "4"^^ . _:b441737466 . _:b441736954 . _:b441736787 . _:b441737730 . . . _:b441736983 "4"^^ . _:b441736786 . . _:b441736982 "4"^^ . _:b441736797 . _:b441737315 . _:b441736977 "4"^^ . _:b441736796 . _:b441736976 "4"^^ . _:b441736799 . _:b441736979 "4"^^ . . . _:b441736798 . _:b441736978 "4"^^ . . _:b441736793 . . _:b441737458 . _:b441736756 . _:b441736989 "4"^^ . . _:b441736792 . . _:b441737250 . _:b441736988 "4"^^ . _:b441736795 . _:b441736991 "4"^^ . _:b441736794 . _:b441736990 "4"^^ . _:b441736805 . . . _:b441736985 "4"^^ . _:b441736804 . _:b441737357 . . _:b8585403 . _:b441736984 "4"^^ . _:b441737147 . . _:b441736807 . . _:b441736767 . _:b8585402 . _:b441736987 "4"^^ . _:b441736806 . . _:b441736975 . _:b441737755 . _:b441736986 "4"^^ . _:b441736801 . _:b441736997 "4"^^ . _:b8585408 . _:b441737212 . _:b441736800 . _:b441736852 . _:b441736996 "4"^^ . _:b441736803 . . . _:b441736999 "4"^^ . _:b441736917 . _:b441736802 . _:b441736998 "4"^^ . _:b441736813 . _:b441737274 . _:b441736993 "4"^^ . . _:b441736812 . . . _:b441736992 "4"^^ . _:b441737198 . . _:b441736815 . _:b441737262 . . _:b441737242 . _:b441736995 "4"^^ . _:b441736814 . . _:b441736994 "4"^^ . _:b441737494 . _:b441736809 . . _:b441737005 "4"^^ . _:b441736960 . _:b441736808 . _:b441737477 . . _:b441737004 "4"^^ . . _:b441737476 . _:b441737279 . _:b441736811 . _:b441737007 "4"^^ . _:b441737488 . _:b441736810 . _:b441737479 . _:b441736761 . _:b441737166 . _:b441737006 "4"^^ . _:b441736821 . _:b441737478 . _:b441737001 "4"^^ . _:b441737081 . _:b441736820 . _:b441737473 . _:b441737000 "4"^^ . _:b441736823 . _:b441737472 . _:b441737555 . _:b441737003 "4"^^ . _:b441737117 . . _:b441737475 . . _:b441736822 . _:b441737002 "4"^^ . _:b441736817 . _:b441737474 . _:b441737013 "4"^^ . _:b441736816 . _:b441737485 . _:b441736806 . _:b441736895 . _:b441737012 "4"^^ . _:b441736819 . _:b441737484 . . . _:b441737381 . _:b441737015 "4"^^ . _:b441737088 . _:b441736834 . _:b441736818 . _:b441737487 . . _:b441737014 "4"^^ . _:b441736829 . _:b441737486 . _:b441737170 . . _:b441736945 . _:b441737009 "4"^^ . _:b441736828 . _:b441737481 . . _:b441737008 "4"^^ . _:b8585385 . _:b441736831 . _:b441737480 . _:b441737011 "4"^^ . _:b441736830 . _:b441737483 . _:b441737010 "4"^^ . . _:b441737482 . _:b441736825 . _:b441737660 . _:b441737021 "4"^^ . _:b441736824 . _:b441737493 . . _:b441737020 "4"^^ . _:b441736827 . _:b441737620 . _:b441737492 . . _:b441737475 . _:b441737316 . _:b441737411 . _:b441737023 "4"^^ . _:b441736826 . _:b441737495 . _:b441737022 "4"^^ . _:b441736837 . _:b441737494 . _:b441737017 "4"^^ . _:b441736836 . _:b441737743 . _:b441737489 . . _:b441737759 . _:b441737076 . _:b441737016 "4"^^ . _:b441736839 . _:b441737488 . _:b441737344 . _:b441737019 "4"^^ . _:b441736838 . _:b441737491 . _:b441736808 . _:b441737018 "4"^^ . . _:b441737490 . _:b441737222 . _:b441737031 . _:b441736833 . _:b441737029 "4"^^ . _:b441736997 . _:b441736832 . _:b441737501 . . . _:b441737028 "4"^^ . _:b441737126 . _:b441736835 . _:b441737500 . . _:b441737462 . _:b441736939 . _:b441737031 "4"^^ . _:b441736834 . _:b441737503 . . _:b441736938 . _:b441736838 . _:b441737030 "4"^^ . _:b441736845 . _:b441737502 . . . _:b441737025 "4"^^ . _:b441736844 . _:b441737497 . _:b441736854 . . _:b441736839 . _:b441737024 "4"^^ . _:b441736847 . _:b441737496 . . _:b441737027 "4"^^ . _:b441736846 . _:b441737499 . _:b441737300 . _:b441737584 . _:b441737026 "4"^^ . _:b441736841 . _:b441737498 . _:b441737037 "4"^^ . _:b441736840 . _:b441737509 . . _:b441737036 "4"^^ . _:b441736843 . _:b441737508 . . _:b441737039 "4"^^ . _:b441736842 . _:b441737707 . _:b441737511 . _:b441737038 "4"^^ . _:b441736853 . _:b441737510 . _:b441737531 . _:b441737033 "4"^^ . _:b441736852 . _:b441737505 . _:b441737261 . _:b441737032 "4"^^ . _:b441736855 . _:b441737504 . _:b441737271 . _:b8585399 "These cells can inhibit anti-tumour responses in an antigen-specific and in a non-specific way [>>1<<,2]. Antigen-specific suppression takes place in lymphoid organs and depends on reactive oxygen species (ROS) production, leading to T cell tolerance. Antigen-non-specific suppression takes place at the tumour site and is mainly dependent" . _:b441737035 "4"^^ . _:b441736854 . _:b441737507 . _:b441737034 "4"^^ . _:b441736849 . _:b441737506 . _:b441737386 . . . _:b441737016 . _:b441737045 "3"^^ . _:b441736848 . _:b441737517 . _:b441737044 "3"^^ . . _:b441736925 . _:b441737516 . _:b441736851 . _:b441737047 "3"^^ . . _:b441736850 . _:b441737519 . . . . _:b441737046 "3"^^ . _:b441736861 . _:b441737518 . _:b441737105 . . _:b441737041 "3"^^ . _:b441736860 . _:b441737513 . . . _:b441737040 "3"^^ . . _:b441736863 . _:b441737512 . _:b441737174 . . _:b441737043 "3"^^ . . _:b441736862 . _:b441737515 . . . _:b441737042 "3"^^ . . _:b441737255 . _:b441736876 . _:b441737514 . . _:b441736857 . _:b441736973 . _:b441737053 "3"^^ . _:b441737461 . _:b441736856 . _:b441737525 . _:b441737052 "3"^^ . . _:b441736859 . _:b441737524 . _:b441737202 . _:b441736859 . . _:b441737055 "3"^^ . _:b441736858 . _:b441737527 . _:b441737080 . _:b441736937 . _:b441737054 "3"^^ . _:b441736869 . _:b441737526 . . _:b441737049 "3"^^ . _:b441736918 . _:b441737758 . _:b441736868 . _:b441737521 . _:b441737048 "3"^^ . _:b441736871 . _:b441737520 . _:b441737051 "3"^^ . _:b441737226 . _:b441736870 . _:b441737523 . . . _:b441737050 "3"^^ . _:b441736865 . _:b441737522 . _:b441737061 "3"^^ . _:b441736864 . _:b441737533 . _:b441737060 "3"^^ . _:b441737241 . _:b441736867 . _:b441737621 . _:b441737532 . . _:b441737376 . _:b441737063 "3"^^ . _:b441736866 . _:b441737535 . . . _:b441737062 "3"^^ . _:b441736877 . _:b441737534 . . _:b441737057 "3"^^ . _:b441737737 . _:b441736876 . _:b441737529 . _:b441737056 "3"^^ . _:b441736879 . _:b441737528 . _:b441736966 . _:b441737059 "3"^^ . _:b441737216 . . _:b441736878 . _:b441737531 . _:b441737058 "3"^^ . _:b441736873 . _:b441737530 . _:b441737069 "3"^^ . _:b441736872 . _:b441737541 . _:b441737068 "3"^^ . . _:b441736875 . _:b441737540 . _:b441737071 "3"^^ . _:b441737520 . _:b441736874 . _:b441737543 . . _:b441737582 . _:b441737070 "3"^^ . . _:b441736885 . _:b441737733 "2"^^ . _:b441737542 . . "10.1186%2F1471-2407-10-464" . _:b441737065 "3"^^ . _:b441736884 . _:b441737732 "2"^^ . _:b441737537 . _:b441737023 . _:b441737064 "3"^^ . _:b441736782 . _:b441737735 "2"^^ . _:b441737536 . _:b441736887 . _:b441737392 . _:b8585410 . _:b441737067 "3"^^ . _:b441736886 . _:b441737734 "2"^^ . _:b441737539 . _:b441737702 . _:b441737066 "3"^^ . _:b441736881 . _:b441737729 "2"^^ . _:b441737538 . _:b441737077 "3"^^ . _:b441736880 . _:b441737728 "2"^^ . _:b441737549 . . . _:b441737076 "3"^^ . _:b441737412 . . _:b441737355 . _:b441736987 . _:b441736883 . _:b441737731 "2"^^ . _:b441737548 . _:b441737064 . _:b441737079 "3"^^ . _:b441736882 . _:b441737730 "2"^^ . _:b441737551 . _:b441737078 "3"^^ . . _:b441736893 . _:b441737741 "2"^^ . _:b441737550 . _:b441737089 . _:b441737073 "3"^^ . . _:b441737741 . _:b441737130 . _:b441736892 . _:b441737740 "2"^^ . _:b441737545 . . _:b441737072 "3"^^ . . _:b441737743 "2"^^ . _:b441737544 . _:b441736895 . _:b441737075 "3"^^ . _:b441737419 . . _:b441737742 "2"^^ . _:b441737547 . _:b441736894 . _:b441737074 "3"^^ . _:b441736914 . _:b441736889 . _:b441737737 "2"^^ . _:b441737546 . _:b441737085 "3"^^ . _:b441736888 . _:b441737736 "2"^^ . _:b441737557 . _:b441737084 "3"^^ . _:b441736891 . _:b441737739 "2"^^ . _:b441737556 . . . _:b441737087 "3"^^ . _:b441737483 . _:b441736890 . _:b441737738 "2"^^ . _:b441737559 . _:b441737431 . . . _:b441737086 "3"^^ . . _:b441737394 . . _:b441736901 . _:b441737749 "2"^^ . _:b441737558 . _:b441736969 . _:b441737081 "3"^^ . _:b441736900 . _:b441737748 "2"^^ . _:b441737553 . _:b441737080 "3"^^ . _:b441736903 . _:b441737751 "2"^^ . _:b441737552 . _:b441737083 "3"^^ . . . . . _:b441737750 "2"^^ . _:b441737555 . _:b441736902 . _:b441737025 . _:b441737082 "3"^^ . . _:b441736897 . _:b441737745 "2"^^ . _:b441737554 . . . . _:b441737093 "3"^^ . _:b441736896 . _:b441737744 "2"^^ . _:b441737565 . . _:b441737092 "3"^^ . . . _:b441737747 "2"^^ . _:b441737564 . _:b441737129 . _:b441736899 . _:b441736769 . _:b441737177 . _:b441737095 "3"^^ . _:b441737223 . _:b441736898 . _:b441737746 "2"^^ . _:b441737567 . . _:b441737094 "3"^^ . . _:b441737757 "2"^^ . _:b441737566 . _:b441737225 . _:b441736909 . _:b441737290 . _:b441737089 "3"^^ . _:b441737442 . _:b441736908 . _:b441737756 "2"^^ . _:b441737561 . . _:b441737088 "3"^^ . _:b441736911 . _:b441737759 "2"^^ . _:b441737560 . _:b441737091 "3"^^ . _:b441737167 . _:b441737073 . _:b441736910 . _:b441737758 "2"^^ . _:b441737563 . _:b441737090 "3"^^ . _:b441737125 . _:b441736905 . _:b441737753 "2"^^ . _:b441737562 . _:b441737101 "3"^^ . _:b441736848 . _:b441737752 "2"^^ . _:b441737573 . _:b441736904 . _:b441737100 "3"^^ . _:b441736907 . _:b441737755 "2"^^ . _:b441737572 . _:b441737012 . . . _:b441737103 "3"^^ . . _:b441736906 . _:b441737754 "2"^^ . _:b441737575 . . . . _:b441737102 "3"^^ . _:b441736917 . _:b441737574 . . _:b441737097 "3"^^ . _:b441736916 . _:b441737764 "2"^^ . _:b441737569 . _:b441737364 . _:b441737096 "3"^^ . _:b441736919 . _:b441737568 . _:b441737043 . _:b441737099 "3"^^ . _:b441737311 . _:b441736918 . _:b441737571 . . _:b441737098 "3"^^ . _:b441736913 . _:b8585370 "More recently, it has been shown that macrophages can be derived from MDSC [>>6<<,29]. Therefore this cell population was also analyzed. Macrophages were characterized by FACS based on their FSC/SSC, in combination with the expression of CD11b, F4/80 and MHCII on their membrane. A significant reduction in macrophages" . _:b441737761 "2"^^ . _:b441737570 . _:b441737120 . _:b441737109 "3"^^ . _:b441736912 . _:b441737760 "2"^^ . _:b441737581 . . . . _:b441737108 "3"^^ . . _:b441736915 . _:b441737763 "2"^^ . _:b441737580 . _:b441737014 . _:b441737111 "3"^^ . _:b441736914 . _:b441737762 "2"^^ . _:b441737583 . _:b441737206 . _:b441737110 "3"^^ . . _:b441737346 . _:b441736925 . _:b441737582 . _:b441737105 "3"^^ . _:b441736924 . _:b441737577 . _:b441737104 "3"^^ . _:b441736927 . _:b441737576 . _:b441737107 "3"^^ . _:b441737513 . . _:b441736926 . _:b441737579 . _:b441737106 "3"^^ . _:b441736921 . _:b441737578 . . _:b441737117 "3"^^ . _:b441736920 . _:b441737589 . . _:b441737116 "3"^^ . _:b441737218 . _:b441737506 . _:b441736923 . _:b441737588 . _:b441737119 "3"^^ . _:b441736922 . _:b441737591 . . . _:b441737118 "3"^^ . _:b441736933 . _:b441737590 . _:b441737113 "3"^^ . . _:b441736932 . _:b441737585 . _:b441737112 "3"^^ . _:b441736935 . _:b441737584 . . _:b441737115 "3"^^ . _:b441737562 . _:b441736934 . _:b441737587 . _:b441737114 "3"^^ . _:b8585398 "background" . _:b441736929 . _:b441737586 . . _:b441737125 "3"^^ . _:b441736928 . _:b441737597 . _:b441737124 "3"^^ . _:b441736931 . _:b441737596 . . _:b441736846 . _:b441737127 "3"^^ . . . _:b441737599 . _:b441736930 . _:b441736777 . _:b8585404 . _:b441737126 "3"^^ . . _:b441737598 . _:b441736941 . _:b441737121 "3"^^ . _:b441736940 . _:b441737593 . _:b441737120 "3"^^ . . _:b441737592 . _:b441736943 . _:b441737123 "3"^^ . . _:b441736942 . _:b441737595 . . _:b441737122 "3"^^ . . _:b441736937 . _:b441737633 . _:b441737594 . _:b441737133 "3"^^ . _:b441737178 . _:b441736936 . _:b441737605 . _:b441737607 . _:b441737132 "3"^^ . _:b441736939 . _:b441737604 . . _:b441737135 "3"^^ . . _:b441737607 . _:b441737521 . _:b441736938 . _:b441736764 . _:b441737134 "3"^^ . _:b441736949 . _:b441737606 . _:b441737129 "3"^^ . _:b441736948 . _:b441737601 . . _:b441737128 "3"^^ . _:b441736951 . _:b441737600 . _:b441737481 . . . _:b441737131 "3"^^ . _:b441736950 . _:b441737603 . _:b441737130 "3"^^ . _:b441737181 . _:b441736945 . _:b441737602 . . _:b441737141 "3"^^ . _:b441736944 . _:b441737613 . _:b441737140 "3"^^ . _:b441736947 . _:b441737612 . . _:b441737699 . . _:b441737171 . _:b441737143 "3"^^ . _:b441736946 . _:b441737615 . . _:b441737142 "3"^^ . _:b441737154 . _:b441736957 . _:b441737614 . _:b441737137 "3"^^ . _:b441736956 . _:b441737609 . . _:b441737136 "3"^^ . . _:b441736959 . _:b441737608 . _:b441737289 . . _:b441737139 "3"^^ . _:b441736958 . _:b441737611 . _:b441737138 "3"^^ . _:b441736788 . . _:b441736953 . _:b441737648 . _:b441737610 . _:b441737149 "3"^^ . . _:b441737621 . _:b441736952 . _:b441737148 "3"^^ . _:b441736955 . _:b441737620 . _:b441737151 "3"^^ . . . _:b441737623 . _:b441736849 . . _:b441736954 . _:b441737469 . . _:b441737150 "3"^^ . _:b441737118 . _:b441737622 . _:b441737145 "3"^^ . _:b441737159 . . _:b441737523 . _:b441737617 . _:b441737609 . _:b441737144 "3"^^ . _:b441737509 . _:b441737328 . . _:b441737150 . . . _:b441737616 . _:b441737147 "3"^^ . _:b441737534 . _:b441737619 . _:b441737146 "3"^^ . . _:b441737618 . _:b441737258 . _:b441737157 "3"^^ . _:b441737629 . . _:b441737156 "3"^^ . _:b441737628 . . _:b441736803 . _:b441737159 "3"^^ . . _:b441737631 . _:b441737158 "3"^^ . _:b441737630 . . _:b441736974 . _:b441737153 "3"^^ . . _:b441737625 . _:b441737373 . _:b441737185 . . . _:b441737152 "3"^^ . . _:b441737624 . _:b441737155 "3"^^ . _:b441737627 . _:b441737154 "3"^^ . _:b441737626 . _:b441737165 "3"^^ . _:b441737637 . _:b441736903 . _:b441737719 . . _:b441737164 "3"^^ . _:b441737301 . _:b441737636 . _:b441737167 "3"^^ . . _:b441737639 . . _:b441737166 "3"^^ . _:b441737638 . _:b441737161 "3"^^ . _:b441737208 . _:b441737633 . _:b441737160 "3"^^ . _:b441737649 . _:b441737599 . _:b441737632 . _:b441737163 "3"^^ . _:b441737276 . _:b441737635 . _:b441737162 "3"^^ . _:b441737451 . _:b441737634 . _:b441737173 "3"^^ . . _:b441737645 . _:b441737172 "3"^^ . . _:b441737644 . . _:b441737175 "3"^^ . _:b441736919 . _:b441737647 . _:b441737413 . . _:b441737174 "3"^^ . _:b441737646 . . _:b441737169 "3"^^ . _:b441737410 . _:b441737641 . . _:b441737168 "3"^^ . _:b441737640 . _:b441737657 . _:b441736792 . _:b441737171 "3"^^ . . _:b441737643 . . _:b441736829 . _:b441737170 "3"^^ . _:b441736893 . . _:b441737642 . . _:b441737181 "3"^^ . _:b441737653 . _:b441737059 . _:b441737180 "3"^^ . _:b441737490 . _:b441737237 . _:b8585391 . _:b441737761 . _:b441737652 . _:b441737183 "3"^^ . _:b441737655 . _:b441737757 . . _:b441737182 "3"^^ . _:b441737654 . _:b441737177 "3"^^ . . _:b441737649 . . _:b441737176 "3"^^ . _:b441737648 . _:b441737179 "3"^^ . _:b441736780 . _:b441737533 . _:b441737651 . . _:b441737178 "3"^^ . . _:b441737444 . _:b441737650 . _:b441737189 "3"^^ . _:b441737661 . _:b441737188 "3"^^ . . _:b441737660 . _:b441737191 "3"^^ . _:b441737663 . _:b441736813 . _:b441737190 "3"^^ . _:b441737662 . _:b441737740 . . _:b441737185 "3"^^ . _:b441737294 . _:b441737657 . . _:b441737184 "3"^^ . _:b441737487 . _:b441737656 . . _:b441737161 . _:b441737187 "3"^^ . _:b441737659 . _:b441737186 "3"^^ . . _:b441737658 . . _:b441737197 "3"^^ . . . _:b441737669 . _:b441737196 "3"^^ . . _:b441737668 . _:b441736875 . _:b441737477 . . _:b441737199 "3"^^ . . _:b441737671 . _:b441737616 . _:b441737198 "3"^^ . _:b441737201 . . _:b441737670 . . _:b441737193 "3"^^ . . . _:b441737665 . _:b441737192 "3"^^ . _:b441737664 . _:b8585405 "The production of ROS by MDSC is highly depending upon cyclooxygenase-2 (COX-2) enzyme activity [8,>>9<<]. The inducible COX-2 enzyme is essential in the biosynthesis of prostaglandins." . _:b441737195 "3"^^ . _:b441737426 . . . _:b441737667 . . _:b441737186 . . . _:b441737194 "3"^^ . _:b441736968 . . _:b441737666 . _:b441737205 "3"^^ . _:b441737677 . _:b441737204 "3"^^ . _:b441737676 . _:b441737635 . . _:b441737207 "3"^^ . _:b441736888 . _:b441737679 . _:b441737206 "3"^^ . . _:b441737678 . _:b441737201 "3"^^ . . _:b441737673 . _:b441737027 . _:b441737200 "3"^^ . _:b441737728 . _:b441737672 . _:b441736851 . _:b441737203 "3"^^ . _:b441736920 . _:b441736980 . _:b441737675 . _:b441737202 "3"^^ . _:b441737365 . _:b441737332 . _:b441737674 . . _:b441737552 . _:b441737213 "3"^^ . _:b441737685 . . _:b441737212 "3"^^ . _:b441737684 . _:b441737215 "3"^^ . _:b441737687 . _:b441737214 "3"^^ . _:b441737686 . _:b441737209 "3"^^ . _:b441737219 . . _:b441737681 . _:b441737224 . . _:b441737208 "3"^^ . . _:b441737680 . _:b441736941 . _:b441737087 . _:b441737211 "3"^^ . . _:b441737683 . _:b441737210 "3"^^ . _:b441737441 . _:b441737682 . _:b441737408 . _:b441737693 . . _:b441737705 . _:b441737692 . _:b441737010 . _:b441737280 . _:b441737695 . _:b441736835 . _:b441737694 . _:b441737700 . _:b441737689 . _:b441737688 . _:b441737439 . _:b441737691 . . _:b441737690 . _:b441737538 . _:b441737683 . _:b441737331 . _:b441737701 . . _:b441737019 . _:b441737700 . . _:b441737645 . . _:b441737703 . . _:b441737702 . _:b441737142 . _:b441737532 . _:b441736907 . _:b441737697 . . _:b441737696 . . _:b441736850 . . _:b441737699 . _:b8585367 _:b8585368 . _:b8585367 _:b8585369 . _:b8585410 . _:b8585367 _:b8585370 . _:b8585367 _:b8585371 . _:b441737698 . _:b441737195 . _:b8585367 _:b8585372 . . _:b8585367 _:b8585373 . _:b8585367 _:b8585374 . . _:b8585367 _:b8585375 . _:b441737709 . . . _:b441737708 . . _:b441737711 . _:b441737602 . . _:b441737710 . . _:b441737705 . _:b441737272 . . _:b8585379 "Subdivision of the heterogeneous group of immature myeloid cells revealed that three types could be identified in tumour-bearing mice, reflecting findings done by others [>>5<<,7]. The PMN-MDSC population was most frequently present in the spleen of tumour-bearing mice. This population was also most capable of ROS production. Previous studies showed that ROS production by MDSC is the main factor for inducing T" . _:b441737704 . . . _:b441737588 . _:b441737707 . . _:b441737101 . _:b441737706 . . _:b441737347 . _:b441737717 . . _:b441736981 . _:b441737217 . _:b8585390 "For example MDSC are critically depending on IFN-\u03B3 production by T cells [>>2<<]. To determine that the abolishment of suppression in celecoxib treatment mice was most likely caused by the reduction of MDSC number and function, we screened splenocytes of all mice for other cell-types." . _:b441737716 . _:b441737589 . _:b441737719 . _:b441737576 . _:b441737718 . . _:b441737713 . _:b441737265 . _:b441737712 . . _:b441736934 . _:b441737715 . _:b441737074 . _:b441737385 . _:b441737714 . . _:b441737725 . . _:b441737724 . . _:b441737727 . _:b8585384 . . . _:b441737726 . . _:b441737721 . _:b8585406 . _:b441737322 . _:b8585374 "In our previous study we have shown that DC-based immunotherapy in this murine model leads to the induction of a strong anti-tumour response [>>28<<]. However, the effectiveness of the anti-tumour response was negatively influenced when tumours sizes increased [28]." . . . _:b441737720 . _:b441737425 . _:b441737399 . _:b441737723 . _:b8585398 _:b8585404 . _:b8585410 "Increased evidence indicates that immune suppressive cells, recruited by tumour-derived factors, are the main cause of failure of novel anti-cancer therapies, including immunotherapy [4,>>19<<-24]. We investigated dendritic cell (DC)-based immunotherapy in a murine model of mesothelioma." . _:b8585398 _:b8585405 . _:b441737406 . . _:b8585398 _:b8585406 . _:b441736932 . _:b441737722 . _:b441736885 . _:b8585398 _:b8585407 . _:b8585398 _:b8585400 . _:b8585398 _:b8585401 . . . _:b441737655 . _:b8585398 _:b8585402 . _:b8585398 _:b8585403 . _:b441737269 . _:b441737221 . . _:b441737628 . _:b8585398 _:b8585399 . _:b441737723 . _:b441737220 . _:b441737223 . _:b8585392 . _:b441737653 . _:b441737222 . . . _:b441737217 . . _:b441736799 . . _:b441737216 . _:b441737219 . _:b441736976 . _:b441737218 . _:b441737044 . _:b441737479 . _:b441737229 . _:b441737478 . _:b441737482 . _:b441737530 . _:b441737228 . _:b441737231 . _:b441737366 . . _:b441737230 . _:b441737619 . _:b441737225 . . _:b441737291 . _:b441737224 . _:b441737189 . _:b441737729 . _:b441737724 . _:b441737447 . _:b441737417 . _:b441737227 . _:b8585378 _:b8585388 . . _:b441736814 . _:b8585378 _:b8585389 . . _:b8585378 _:b8585390 . . _:b441737226 . _:b8585378 _:b8585391 . _:b8585378 _:b8585384 . _:b8585376 _:b8585377 . _:b8585378 _:b8585385 . _:b8585378 _:b8585386 . _:b8585378 _:b8585387 . _:b441737237 . . . _:b8585378 _:b8585380 . . . . _:b8585378 _:b8585381 . . . _:b8585378 _:b8585382 . _:b8585378 _:b8585383 . _:b441737236 . _:b441736754 . _:b441737732 . _:b8585378 _:b8585379 . _:b441737239 . _:b441737733 . . _:b441737021 . _:b441737734 . _:b441737735 . _:b441737728 . _:b441737729 . _:b441737238 . _:b441737730 . _:b441737731 . _:b441737740 . . _:b441737233 . _:b441737741 . _:b8585378 _:b8585396 . _:b441737742 . _:b8585378 _:b8585397 . _:b441737743 . _:b441737736 . _:b441737737 . _:b441737232 . _:b441737022 . _:b8585378 _:b8585392 . _:b441737738 . _:b8585378 _:b8585393 . _:b441737739 . _:b8585378 _:b8585394 . . _:b441737748 . _:b8585378 _:b8585395 . _:b441737235 . _:b441737749 . _:b441737750 . _:b441737751 . _:b441737744 . . _:b441737234 . _:b441737745 . _:b441737746 . _:b441737686 . . _:b441737747 . . _:b441737756 . _:b441737757 . _:b441737245 . _:b441737758 . _:b441737759 . _:b441737752 . . _:b441737244 . _:b441737753 . . _:b441737754 . _:b441737714 . . _:b441736802 . _:b441737755 . . _:b441737764 . . _:b441737247 . . _:b441737760 . _:b441737761 . _:b441737246 . _:b441737762 . _:b441737184 . _:b441737763 . _:b441737241 . _:b441736902 . _:b8585398 _:b8585412 . _:b441737240 . _:b8585398 _:b8585408 . _:b8585398 _:b8585409 . _:b8585398 _:b8585410 . _:b8585398 _:b8585411 . _:b441737243 . _:b441737242 . _:b441737253 . . _:b441737338 . . _:b441737252 . . _:b441737368 . _:b441737617 . _:b441737072 . _:b441737255 . . _:b441737254 . . _:b441737249 . _:b441737636 . . _:b441737248 . . _:b441737251 . _:b441737629 . . _:b441736768 . _:b441737250 . _:b441736964 . _:b441737095 . . _:b441737153 . _:b441737527 . _:b441737261 . . . _:b441737260 . . _:b441736881 . . _:b441736891 . . . _:b441737263 . . . _:b441737262 . . _:b441737257 . . . . _:b441737256 . _:b441737155 . . . _:b441737259 . . . _:b441737517 . . . . _:b441737258 . . _:b441737269 . _:b8585408 . _:b441737423 . _:b441737318 . . _:b441737268 . _:b441737062 . _:b441737271 . _:b441737402 . . _:b441737465 . _:b441737053 . _:b8585391 . _:b441737270 . . . _:b441737265 . . _:b441737563 . _:b441737264 . _:b8585402 "Polymorph nuclei MDSC (PMN-MDSC), mononuclear MDSC (MO-MDSC) and Gr-1low MDSC [>>5<<-7]. Greifenberg et. al. showed that the MO-MDSC and a subpopulation of Gr-1low MDSC can inhibit T cell proliferation by the production of NO, in contrast to the PMN-MDSC that did not show this suppressive capacity [5]. However, the exact" . . _:b8585384 "The decrease in COX-2 enzyme expression has been observed in other studies [>>31<<-33]. The mechanism by which celecoxib perturbs COX-2 protein expression is not known. It has been suggested that PGE2 functions as a feedback on COX-2 protein expression and that celecoxib inhibits this loop [34]. It is also possible that" . _:b441737267 . . _:b441737372 . _:b441737266 . _:b441737230 . _:b441737277 . _:b441737276 . _:b441737742 . _:b441736828 . _:b441737029 . _:b441737279 . _:b441736781 . _:b441737278 . _:b441737227 . _:b441737273 . . _:b441737272 . . . _:b441737275 . _:b441737107 . _:b441737697 . . _:b441737274 . . . _:b441737285 . _:b441737086 . _:b441737284 . _:b441737287 . _:b441737391 . . _:b441737286 . _:b441736860 . . _:b441737281 . . _:b441737280 . _:b441736786 . _:b441737283 . _:b8585407 . . _:b441737282 . . _:b441736840 . _:b441737662 . _:b441737293 . . _:b441737292 . _:b441737098 . _:b441737065 . . _:b441737175 . _:b441737295 . . _:b441737294 . . _:b441737586 . _:b441736880 . _:b441737289 . . . _:b441737288 . _:b441737291 . _:b441737133 . _:b441737508 . _:b441737290 . _:b441736924 . _:b441737301 . _:b441737256 . _:b441737300 . _:b441737351 . _:b441737476 . _:b441737477 . _:b441737303 . _:b441737017 . _:b441737478 . _:b441737479 . . _:b441737472 . _:b441737473 . _:b441737302 . _:b441737474 . _:b441737475 . _:b441737484 . _:b441737485 . _:b441737297 . _:b441737486 . _:b8585378 "discussion" . _:b441737744 . _:b441737487 . _:b441736935 . _:b441737480 . _:b441737481 . _:b441737296 . _:b441737482 . _:b441737483 . _:b441737492 . _:b441737493 . _:b441737299 . _:b441737494 . . _:b441737495 . _:b441737488 . . _:b8585387 . _:b441737298 . _:b441737489 . _:b441737490 . _:b441737491 . . _:b441737500 . . _:b441737501 . _:b441737309 . _:b441737502 . _:b441737503 . _:b441737496 . _:b441737497 . _:b441737308 . _:b441737498 . _:b441737499 . _:b441737508 . . _:b441737311 . _:b441737247 . _:b441737509 . _:b441737510 . _:b441737511 . . _:b441737504 . _:b441737505 . _:b441737310 . _:b441737506 . _:b441737507 . _:b441737516 . _:b441737517 . _:b441737305 . . . _:b441737518 . _:b441737519 . _:b8585393 . _:b441737512 . _:b441737513 . _:b441737314 . _:b441737304 . _:b441737514 . _:b441737310 . . _:b8585406 . _:b441737515 . _:b441737524 . _:b441737525 . _:b441737307 . _:b441737526 . _:b441737527 . _:b441737520 . . _:b441737521 . _:b441737306 . _:b441736841 . _:b441737522 . . _:b441737523 . _:b441737532 . _:b441737533 . _:b441737317 . _:b441737534 . _:b441736836 . _:b441737535 . . _:b441737528 . _:b441737529 . _:b441737316 . _:b441737530 . _:b441737531 . _:b441737763 . . _:b441737540 . . . _:b8585391 "Significant correlations between the levels of COX-2 expression and survival were observed in many human cancers [>>38<<-40], including malignant pleural mesothelioma." . _:b441737718 . _:b441737319 . _:b441737541 . _:b441737542 . _:b441737370 . _:b441737543 . . _:b441737536 . . _:b441737597 . _:b441737318 . . _:b441737537 . _:b441737538 . _:b441737455 . . _:b441737079 . _:b441737539 . _:b441737548 . _:b441737549 . _:b441737313 . . _:b441737640 . _:b441737550 . _:b441737551 . . _:b441737544 . . _:b441737312 . _:b441737545 . _:b441737546 . _:b441737547 . _:b441737556 . _:b441737557 . _:b441737315 . . _:b441737558 . . _:b441737559 . . _:b441737552 . _:b441736988 . _:b441737553 . _:b441737314 . . _:b441737075 . _:b441737554 . . _:b441737555 . _:b441737564 . _:b441737725 . _:b441737565 . _:b441737409 . _:b441737325 . _:b441737566 . _:b441737567 . _:b441737560 . _:b441737561 . _:b441737324 . _:b441737562 . _:b441737563 . . _:b441737572 . . _:b441737651 . _:b441737327 . _:b441737573 . _:b441737574 . _:b441737575 . . _:b441737568 . . _:b441737326 . _:b441737569 . _:b441737570 . _:b441737571 . _:b441737580 . _:b441737581 . _:b441737321 . _:b441737582 . _:b441737583 . _:b441737576 . _:b441737577 . _:b441737320 . _:b441737578 . _:b441737579 . _:b441737588 . _:b441737589 . _:b441737323 . _:b441737590 . _:b8585388 "We have previously shown that upon injection of antigen-loaded DCs an effective immune response can be induced in a mouse model for mesothelioma depending on the timing of the immunotherapy [>>28<<]. In this study we were able to show that the reduction of MDSC in vivo was associated with an improved anti-tumour response and resulted in prolongation of survival in combination with DC-based immunotherapy. Same results were reported" . _:b441737666 . . _:b441737591 . _:b441736816 . _:b8585368 . _:b441737584 . . _:b441737585 . _:b441737322 . . _:b441737586 . . _:b441737587 . _:b441737596 . _:b441737597 . _:b441737333 . . _:b441737598 . _:b441737599 . _:b441737592 . _:b8585370 . _:b441737337 . _:b441737593 . _:b441737716 . _:b441737332 . _:b441737594 . _:b441737046 . _:b441736992 . . _:b441737595 . _:b441737604 . _:b441737605 . _:b441737335 . _:b441737606 . _:b441737607 . _:b441737600 . . _:b441737334 . _:b441737601 . . _:b441737602 . _:b441737007 . _:b441737603 . _:b441737612 . _:b441737613 . _:b441737329 . _:b441737614 . _:b441737727 . _:b441737615 . _:b441737608 . _:b441737497 . _:b441737609 . _:b441737328 . _:b441737610 . . _:b441737611 . _:b441737620 . _:b441737621 . _:b441737331 . _:b441737622 . _:b441737623 . _:b441737616 . . _:b441737330 . _:b441737617 . _:b441737618 . _:b441737547 . . _:b441737619 . _:b441737628 . _:b441737629 . _:b441737341 . _:b441737630 . _:b441737631 . _:b441737624 . _:b441737665 . _:b441736778 . _:b441737625 . _:b441737340 . _:b441737298 . _:b441737626 . _:b441737627 . _:b441737636 . . _:b441737343 . _:b441737637 . . _:b441737638 . _:b441737639 . _:b441737632 . _:b441737633 . _:b441737342 . _:b441737049 . _:b441737634 . _:b441737635 . _:b441737644 . _:b441737645 . _:b441737337 . _:b441737646 . _:b441737647 . _:b441736821 . _:b441737640 . _:b441737452 . _:b441737641 . _:b441737336 . _:b441736779 . _:b441737642 . . _:b441737643 . _:b441736819 . _:b441737179 . _:b441737652 . _:b441737653 . _:b441737339 . _:b441737654 . _:b441737655 . _:b441737648 . _:b441737203 . _:b441737649 . _:b441737338 . . _:b441737650 . _:b441737651 . _:b441737660 . _:b441737661 . _:b441737349 . _:b441737662 . _:b441737663 . _:b441737656 . . _:b441737348 . _:b441737657 . _:b441737658 . _:b441737659 . _:b441737668 . _:b441737669 . _:b441737351 . _:b441737670 . _:b441737671 . . _:b441737664 . _:b441737665 . _:b441737350 . . _:b441737666 . _:b441737667 . _:b441737676 . _:b441737677 . _:b441737345 . _:b441737033 . _:b441737678 . _:b441737004 . _:b441737679 . _:b441737672 . _:b441737673 . _:b441737344 . _:b441737674 . _:b441737675 . _:b441737684 . _:b441737720 . _:b441737685 . _:b441737347 . _:b441737686 . _:b441737687 . _:b441737680 . _:b441737681 . _:b441737346 . _:b441737682 . _:b441737683 . _:b441737343 . _:b441737692 . _:b441737693 . _:b441737357 . . . _:b441737694 . _:b441737006 . _:b441737695 . _:b441737688 . . _:b441737356 . _:b441737689 . _:b441737690 . _:b441737121 . _:b441737691 . _:b441737700 . _:b441737701 . _:b441737359 . _:b441736933 . _:b441737702 . . _:b441737703 . _:b441737696 . . _:b441737358 . _:b441737697 . _:b441737698 . _:b441737699 . _:b441737708 . _:b441737709 . _:b441737603 . _:b441737353 . _:b441737710 . . _:b441737160 . _:b441737711 . _:b441737704 . _:b441737705 . _:b441737352 . _:b441737706 . _:b441737707 . _:b441737764 . _:b441736823 . _:b441737716 . _:b441737717 . _:b441737355 . _:b441737718 . . _:b441737719 . _:b441736900 . _:b441737712 . _:b441737713 . _:b441737354 . _:b441737714 . _:b441737715 . _:b441737724 . _:b441737725 . _:b441737365 . _:b441737726 . _:b441737727 . . _:b8585402 . _:b441737720 . _:b441737721 . _:b441737364 . . _:b441737722 . _:b441737723 . _:b441737220 . _:b441737221 . _:b441737367 . . _:b441737222 . . _:b441737223 . _:b441737216 . _:b441737217 . _:b441737366 . _:b8585367 "results" . _:b441737218 . . _:b441737219 . _:b441737228 . _:b441737229 . _:b441737361 . _:b441737230 . _:b441737231 . _:b441737224 . . _:b441737360 . _:b441737225 . _:b441737226 . _:b441737227 . . _:b441737236 . _:b441737237 . _:b441737363 . _:b441737238 . . _:b441737239 . _:b441736760 . _:b441737232 . _:b441737233 . _:b441737362 . _:b441737234 . . _:b441737760 . _:b441737235 . . _:b441736926 . _:b441737244 . _:b441737245 . _:b441737373 . _:b441736798 . _:b441737246 . . _:b441737247 . . _:b441737240 . _:b441737241 . _:b441737372 . _:b441737242 . _:b441737243 . _:b441736985 . _:b441737252 . _:b441737253 . _:b441737663 . _:b441737375 . _:b441737254 . _:b441737255 . _:b441737248 . _:b441737249 . _:b441737374 . _:b441737250 . _:b441737251 . _:b441737260 . _:b441737261 . _:b441737492 . _:b441737369 . _:b441737262 . _:b441737630 . . _:b441737263 . _:b441737256 . _:b441737257 . _:b441737368 . _:b441737258 . _:b441737333 . _:b441737259 . _:b441736889 . _:b441737268 . . _:b441737371 . _:b441737303 . _:b441737057 . _:b441737269 . _:b441737270 . _:b441737271 . _:b441737264 . _:b441737265 . _:b441737639 . _:b441737370 . _:b441737236 . _:b441737266 . _:b441737267 . _:b441737276 . _:b441737277 . _:b441737381 . _:b441737278 . . _:b441737279 . _:b441736956 . . _:b441737272 . _:b441737273 . _:b441737380 . _:b441737274 . _:b441737275 . _:b441737284 . _:b441737285 . _:b441737383 . _:b441737286 . . _:b441737287 . _:b441737280 . _:b441737281 . _:b441737382 . _:b441737282 . _:b441737283 . _:b441737292 . _:b441737293 . _:b441737377 . _:b441737294 . _:b441737295 . _:b441737516 . . _:b441737288 . . _:b441737376 . _:b441737289 . . _:b441737290 . _:b441737291 . _:b441737300 . _:b441737301 . _:b441737379 . . _:b441737302 . _:b441737303 . _:b441737296 . _:b441737297 . _:b441737378 . _:b441737298 . _:b8585395 "Although it is generally accepted that MDSC are part of the tumour microenvironment [>>19<<], their numbers or function may differ in various tumour cell-lines or other tumour model." . _:b441737299 . _:b441737308 . _:b441737309 . _:b441737389 . _:b441737310 . . _:b441737311 . _:b441737304 . _:b441737305 . _:b441737388 . _:b441737306 . . . _:b441737307 . _:b441737316 . _:b441737317 . _:b441737391 . _:b441737318 . _:b441737319 . . _:b441737312 . _:b441737313 . _:b441737581 . _:b441737390 . _:b441737314 . . _:b441737315 . _:b441737574 . _:b441737324 . _:b441737325 . _:b441737385 . _:b441737288 . _:b441737326 . _:b441737327 . _:b441737320 . _:b441737263 . _:b441737321 . _:b441737384 . _:b441737322 . _:b441737323 . . _:b441737332 . _:b441737333 . _:b441737387 . _:b441737334 . _:b441737335 . _:b441737328 . _:b441737329 . _:b441737386 . _:b441737330 . _:b441737275 . . _:b441737618 . _:b441737331 . _:b441737340 . _:b441737197 . _:b441737341 . _:b441737397 . _:b441737342 . _:b441737343 . _:b441736844 . _:b441737674 . _:b441737336 . _:b441737337 . _:b441737396 . _:b441737338 . _:b441737339 . . _:b441737348 . _:b441737349 . _:b441737399 . . _:b441737350 . _:b441737351 . . _:b441737344 . _:b441737345 . _:b441737398 . _:b441737346 . _:b441737347 . _:b441737356 . _:b441737357 . _:b441737393 . _:b441737358 . _:b441737359 . _:b441737352 . _:b441737353 . _:b441737392 . _:b441737354 . _:b441737355 . . _:b441737364 . _:b441737365 . _:b441737395 . _:b441736790 . _:b441737084 . _:b441737366 . _:b441737367 . _:b441737360 . _:b441737361 . _:b441737394 . _:b441737362 . _:b441737363 . _:b441737372 . _:b441737373 . _:b441737405 . . _:b441737374 . _:b441737375 . _:b441737368 . _:b441737369 . _:b441737404 . . _:b441737370 . _:b441737371 . _:b441737124 . _:b441737380 . _:b441737381 . _:b441737407 . _:b441737382 . _:b441737383 . _:b441737376 . _:b441737414 . . _:b441737377 . _:b441737406 . _:b441737378 . . _:b441737379 . _:b441737388 . _:b441737389 . _:b8585404 "The production of ROS by MDSC is highly depending upon cyclooxygenase-2 (COX-2) enzyme activity [>>8<<,9]. The inducible COX-2 enzyme is essential in the biosynthesis of prostaglandins." . _:b441737559 . _:b441737401 . _:b441737232 . . _:b441737390 . _:b441737391 . _:b441736833 . _:b441737535 . _:b441737384 . . _:b441736791 . . _:b441737400 . _:b441737385 . . _:b441737386 . _:b441737387 . _:b441737396 . _:b441737397 . _:b441737403 . _:b441737398 . _:b441737399 . _:b441737392 . _:b441737393 . _:b441737402 . _:b441737323 . _:b441737394 . _:b441737395 . _:b441737404 . _:b441737405 . _:b441737413 . . _:b441737406 . _:b441737407 . . _:b441737634 . _:b441737400 . _:b8585367 . _:b441737412 . _:b441737401 . _:b441737402 . _:b441737403 . _:b441737412 . _:b441737413 . _:b441737415 . _:b441737414 . _:b441737598 . _:b441737415 . . _:b441737140 . _:b441737408 . _:b441737409 . _:b441737474 . _:b441737414 . _:b441737410 . _:b441737411 . _:b441736862 . _:b441737420 . . _:b441737409 . _:b441737421 . _:b441737422 . _:b441737423 . _:b441737416 . . _:b441737417 . _:b441737408 . . _:b441737418 . _:b441737419 . _:b441737428 . _:b441737429 . _:b441737411 . _:b441737430 . _:b441737431 . . _:b441737424 . _:b441737425 . _:b441737410 . _:b441737426 . _:b441737427 . _:b441737436 . _:b441737437 . _:b441737421 . _:b441736978 . . _:b441737438 . _:b441737439 . _:b8585398 . _:b441737193 . _:b441737432 . _:b441737433 . _:b441737420 . _:b441737434 . . _:b441737435 . . . _:b441737650 . _:b441737444 . _:b441737445 . _:b441737423 . _:b441737446 . _:b441737447 . _:b441737207 . . _:b441737440 . _:b441736830 . _:b441737615 . _:b441737422 . _:b441737441 . _:b441737442 . _:b441737443 . _:b441737484 . _:b441737452 . _:b441737453 . _:b441737417 . _:b441737454 . _:b441737455 . _:b441737448 . _:b441737449 . _:b441737416 . _:b8585376 . _:b441737450 . _:b441737451 . _:b8585378 . _:b441737460 . _:b441737461 . _:b441737419 . . _:b441737462 . _:b441737463 . _:b441737456 . _:b441737457 . _:b441737418 . _:b441737035 . _:b441737458 . _:b441737299 . . _:b441737459 . _:b441737468 . . _:b441737429 . . _:b441737469 . . _:b441737470 . _:b441737471 . . _:b441737464 . _:b441737465 . _:b441737428 . _:b441737466 . _:b441737467 . . _:b441737431 . _:b441736882 . . _:b441737430 . _:b441737180 . . _:b441737425 . . _:b441737424 . _:b441737427 . _:b441737426 . . _:b441737437 . _:b441737638 . _:b441736772 . _:b441737436 . _:b441737439 . _:b8585380 "Subdivision of the heterogeneous group of immature myeloid cells revealed that three types could be identified in tumour-bearing mice, reflecting findings done by others [5,>>7<<]. The PMN-MDSC population was most frequently present in the spleen of tumour-bearing mice. This population was also most capable of ROS production. Previous studies showed that ROS production by MDSC is the main factor for inducing T" . _:b441737438 . . _:b441736845 . _:b441737688 . _:b441736770 . _:b441737433 . _:b441737432 . _:b441737435 . _:b8585393 "For this reason COX-2 inhibition has been proposed as potential therapeutic target for mesothelioma [10,>>11<<]. Also PGE2 contributes to proliferation, survival, angiogenesis, migration and invasion of tumour cells [41]." . _:b441737320 . _:b441737000 . _:b441737182 . _:b441737434 . . _:b441736951 . _:b441737445 . . _:b441737537 . _:b441737444 . _:b441737447 . _:b441737446 . _:b441737471 . . _:b441737441 . _:b8585383 "recently showed that this population was not capable of NO production and therefore showed no suppressive effect on T cell proliferation in a T cell mixed leukocyte reaction (MLR) [>>5<<]. However, our data provides evidence that PMN-MDSC do play a significant role in tumour-induced immune suppression, since PMN-MDSC are most capable of producing ROS and thereby contribute to the induction of tolerance. Induction of" . . _:b441737440 . _:b441737428 . _:b441737008 . _:b441737443 . . . _:b441737442 . . _:b441737659 . _:b441737583 . _:b441737453 . _:b8585384 . _:b441737009 . _:b441737452 . _:b441737455 . _:b441737463 . _:b441737200 . _:b441737454 . _:b441737457 . . _:b441736901 . _:b441737449 . . . _:b441737448 . . _:b441737137 . _:b441737348 . _:b441737277 . _:b441737451 . . _:b441737604 . _:b441737096 . _:b441737643 . _:b441737450 . . . _:b441736827 . _:b441737151 . _:b441737461 . . _:b441737460 . _:b441737463 . . _:b441737037 . _:b441737462 . _:b441737457 . _:b441736762 . _:b441737456 . . _:b441737459 . _:b8585390 . . . _:b441737458 . . . _:b8585410 . . _:b441737469 . _:b441737625 . _:b441737459 . _:b441737468 . _:b441737069 . _:b441737471 . . _:b441737528 . _:b441737594 . _:b441737470 . . _:b441737115 . _:b441737465 . _:b441737541 . _:b441737464 . _:b441737467 . . _:b441736868 . . _:b441737466 . _:b441737169 . _:b441736864 . . _:b441737183 . _:b441737668 . . . _:b441737112 . _:b441737128 . _:b441736872 . . _:b8585400 . _:b8585401 . _:b441737566 . . _:b441737362 . _:b441737529 . . _:b441737163 . _:b441737321 . . . . . . _:b441737420 . _:b441737148 . _:b8585403 "showed that the MO-MDSC and a subpopulation of Gr-1low MDSC can inhibit T cell proliferation by the production of NO, in contrast to the PMN-MDSC that did not show this suppressive capacity [>>5<<]. However, the exact mechanisms that play a role in the induction of T cell tolerance by MDSC subtypes need to be further explored. As ROS production by MDSC also contributes to the induction of tolerance we determined the ROS producing" . _:b441737669 . . _:b441736896 . _:b441737383 . . . _:b441736874 . _:b441737601 . . _:b441736944 . . . _:b441737642 . . _:b441737050 . . . . _:b441736964 . _:b441736965 . _:b441737377 . _:b441737041 . _:b441736966 . . _:b441736967 . _:b441736960 . _:b441736961 . . . _:b441736962 . _:b441736963 . _:b441736972 . _:b441736973 . . _:b441736974 . _:b441736975 . _:b441736869 . _:b441736968 . _:b441736969 . _:b441736970 . _:b441736971 . _:b441736980 . _:b441736981 . _:b441737199 . _:b441736982 . _:b441736983 . . _:b441736976 . . _:b441736977 . _:b441737738 . _:b441736978 . _:b441736979 . _:b441736988 . _:b441736989 . _:b441736990 . . _:b441736991 . _:b441736984 . _:b441736985 . _:b441736986 . _:b441736987 . _:b441736996 . _:b441736997 . _:b441736832 . _:b441736998 . _:b441736999 . _:b441736992 . _:b441736993 . _:b441736994 . _:b441736995 . _:b8585401 . _:b441737004 . . _:b441737005 . _:b441737006 . _:b441736915 . _:b441737007 . _:b441737000 . _:b441737001 . _:b441737002 . _:b441736909 . _:b441737003 . _:b441737012 . _:b441737013 . _:b441737014 . _:b441737015 . _:b441737008 . _:b441737009 . _:b441737010 . _:b441737011 . _:b441737519 . _:b441737020 . . _:b441737021 . _:b441737022 . _:b441737023 . _:b441737016 . . _:b441737017 . _:b441737676 . _:b441737018 . _:b441737019 . _:b441737028 . _:b441737029 . _:b441737030 . _:b441737031 . . _:b441737024 . _:b441737025 . _:b441737026 . _:b441737027 . _:b441737036 . _:b441737037 . _:b441737543 . _:b441737038 . _:b441737039 . _:b441737032 . _:b441737033 . _:b441737034 . _:b441737035 . _:b441737044 . _:b441737045 . _:b441737046 . _:b441737047 . _:b441737127 . . _:b441737040 . _:b441737395 . _:b441737041 . _:b441737042 . _:b441737043 . _:b441736904 . _:b441737052 . _:b441737053 . _:b441737054 . _:b441737055 . . _:b441737048 . _:b441737049 . _:b441737050 . _:b441737051 . . _:b441737060 . . _:b441737061 . _:b441737162 . _:b441737062 . _:b441737063 . _:b441736870 . _:b441737056 . . . _:b441737057 . _:b441737058 . _:b441737059 . _:b441737068 . _:b441737577 . _:b441737069 . _:b441737070 . _:b441737071 . _:b441737064 . _:b441737065 . _:b441737066 . _:b441737067 . _:b441737076 . _:b441737077 . _:b441737210 . _:b441737078 . _:b441737079 . _:b441737092 . _:b441737072 . _:b441737073 . _:b441737074 . _:b441737075 . _:b441737084 . _:b441737085 . _:b441737086 . . . . _:b441737087 . _:b441737264 . _:b441737080 . . _:b441737081 . _:b441737082 . _:b441737173 . _:b441737083 . _:b441737092 . _:b441737093 . _:b441737094 . _:b441736994 . _:b441737095 . . _:b441737088 . _:b441737089 . _:b441737690 . . _:b441737090 . . _:b441737091 . _:b441737100 . _:b441737101 . _:b441737102 . _:b441737103 . _:b441737099 . _:b441737096 . _:b441737097 . _:b441737098 . _:b441737099 . _:b441737108 . _:b441737109 . _:b441737110 . . _:b441737111 . _:b441737430 . . _:b441737104 . _:b441737600 . . _:b441737105 . . _:b441737106 . . . _:b441737107 . _:b441737116 . _:b441737117 . _:b441736831 . _:b441737118 . _:b441737119 . _:b441737112 . . _:b441737113 . . _:b441737114 . . _:b441737115 . _:b441737124 . _:b441737221 "3"^^ . _:b441737125 . _:b441737126 . . _:b441737127 . _:b441737120 . _:b441737220 "3"^^ . . _:b441737121 . _:b441737122 . _:b441737123 . _:b441737132 . _:b441737223 "3"^^ . _:b441737133 . _:b441737134 . _:b441737135 . _:b441737128 . _:b441737222 "3"^^ . _:b441737129 . _:b441737130 . _:b441737131 . _:b441737140 . _:b441737217 "3"^^ . _:b441737141 . _:b441737142 . _:b441737143 . _:b441737136 . _:b441737216 "3"^^ . _:b441737137 . _:b441737135 . _:b441737138 . _:b441737404 . _:b441737244 . _:b441737139 . _:b441737148 . _:b441737219 "3"^^ . _:b441737149 . . _:b441737150 . _:b441737433 . _:b441737151 . _:b441737144 . _:b441737218 "3"^^ . _:b441737145 . _:b441737146 . . . _:b441737147 . _:b441737156 . _:b441737229 "3"^^ . _:b441737157 . _:b441737158 . _:b441737159 . _:b441737152 . _:b441737228 "3"^^ . _:b441737153 . _:b441737154 . _:b441737155 . _:b441737164 . _:b441737231 "3"^^ . _:b441737165 . _:b441737166 . _:b441737427 . _:b441737167 . _:b441737160 . _:b441737230 "3"^^ . _:b441737161 . _:b441737512 . _:b441737162 . _:b441737055 . _:b441737163 . _:b441737172 . _:b441737225 "3"^^ . _:b441737194 . _:b441737173 . _:b441737174 . _:b441737175 . _:b441737168 . _:b441737540 . _:b441737224 "3"^^ . _:b441737169 . _:b441737170 . _:b441737171 . _:b441737180 . _:b441737227 "3"^^ . . _:b441737181 . _:b441736921 . _:b441737182 . _:b441737183 . _:b441737176 . _:b441737226 "3"^^ . _:b441736785 . _:b441737177 . _:b441737178 . _:b441737179 . _:b441737237 "2"^^ . . _:b441737188 . _:b441737189 . _:b441737190 . _:b441737191 . _:b441737236 "2"^^ . _:b441737184 . _:b441737185 . _:b441737505 . _:b441737186 . _:b441737187 . _:b441737239 "2"^^ . _:b441737196 . _:b441737197 . _:b441737198 . _:b441737199 . _:b441737238 "2"^^ . . _:b441737192 . _:b441737032 . _:b441737193 . _:b441737194 . _:b441737195 . _:b441737233 "2"^^ . _:b441737204 . _:b441737205 . _:b441737206 . _:b441737526 . _:b441737207 . _:b441737232 "2"^^ . _:b441737200 . _:b441737201 . _:b441737369 . _:b441737202 . _:b441737203 . _:b441737235 "2"^^ . _:b441737212 . _:b441737213 . _:b441737214 . _:b441737215 . _:b441737443 . _:b441737234 "2"^^ . _:b441737208 . _:b441737209 . . . _:b441737210 . _:b441737211 . _:b441737245 "2"^^ . . _:b8585407 "In addition, several studies showed the relevance of COX-2 inhibition in cancer progression [>>13<<-15]. Although the relation between COX-2 over-expression and prostaglandin E2 (PGE2) synthesis in cancer has been studied extensively, the impact on the tumour microenvironment is still under investigation [16-18]." . . _:b441737244 "2"^^ . _:b441737136 . _:b441737652 . _:b441736843 . . _:b441736883 . _:b441737247 "2"^^ . . _:b441737061 . _:b441737246 "2"^^ . _:b441737342 . _:b441737241 "2"^^ . _:b441737752 . _:b441737240 "2"^^ . _:b8585373 "It has been shown that MDSC can down regulated the \u03B6-chain on T cells by ROS production in the lymphoid organs and thereby induce T cell tolerance [19,>>30<<]. We analyzed splenocytes of dietary celecoxib treated and untreated mice for their capability to produce ROS." . _:b8585401 . . _:b441737243 "2"^^ . . . . _:b441737242 "2"^^ . _:b441737190 . _:b441737283 . . _:b441737449 . _:b441737253 "2"^^ . _:b441737252 "2"^^ . . . _:b441737255 "2"^^ . _:b8585408 "Although the relation between COX-2 over-expression and prostaglandin E2 (PGE2) synthesis in cancer has been studied extensively, the impact on the tumour microenvironment is still under investigation [>>16<<-18]." . _:b441737052 . _:b441737254 "2"^^ . _:b441737405 . _:b441737249 "2"^^ . _:b441736756 . _:b441736757 . _:b441736758 . _:b441736811 . _:b441736759 . _:b441737248 "2"^^ . _:b441736752 . _:b441736753 . _:b441736754 . _:b441736755 . _:b441737473 . _:b441737251 "2"^^ . _:b441736764 . _:b441736765 . _:b441736766 . . _:b441736894 . _:b441736767 . _:b441737250 "2"^^ . . _:b441736760 . _:b441736761 . _:b441736762 . _:b441736763 . _:b441737261 "2"^^ . . _:b441736772 . . _:b441736773 . _:b441736774 . _:b441736775 . _:b441737260 "2"^^ . _:b441736768 . _:b441736769 . . _:b441736770 . _:b441736771 . _:b441737263 "2"^^ . _:b441736780 . _:b441736865 . _:b441736781 . _:b441736782 . _:b441736783 . _:b441737262 "2"^^ . . _:b441736776 . _:b441736777 . _:b441736778 . _:b441736779 . _:b441737257 "2"^^ . _:b441736788 . . _:b441736789 . _:b441736790 . _:b441737440 . . _:b441736791 . _:b441737256 "2"^^ . . _:b441736784 . _:b441736785 . _:b441736786 . _:b441736787 . _:b441737259 "2"^^ . _:b441736796 . _:b441736797 . _:b441736798 . _:b441736799 . _:b441737500 . _:b441737258 "2"^^ . _:b441736792 . . _:b441736793 . _:b441736794 . _:b441736795 . _:b441737269 "2"^^ . _:b441736804 . _:b441736805 . _:b441736806 . _:b441736807 . _:b441737268 "2"^^ . _:b441736800 . . _:b441736801 . _:b441736802 . _:b441737211 . _:b441736803 . _:b441737271 "2"^^ . _:b441736812 . _:b441736813 . _:b441736814 . _:b8585384 . _:b441736815 . _:b441737270 "2"^^ . _:b441736912 . _:b441736808 . _:b441736809 . . _:b441736810 . _:b441737209 . _:b441736811 . _:b441737325 . _:b441737265 "2"^^ . _:b441736766 . _:b441736820 . _:b441736821 . _:b441736822 . _:b441737278 . _:b441736823 . _:b441737264 "2"^^ . _:b441736816 . _:b441737228 . _:b441736817 . _:b441736818 . . _:b441736819 . _:b441737267 "2"^^ . . _:b441736892 . _:b441736828 . . _:b441736829 . _:b441736830 . _:b441736831 . _:b441737266 "2"^^ . _:b441736824 . . _:b441736825 . _:b441736826 . _:b441736827 . _:b441737277 "2"^^ . _:b441736836 . . _:b441736837 . _:b441736838 . _:b441736839 . _:b441737276 "2"^^ . _:b441736832 . . _:b441736833 . _:b441736834 . _:b441736835 . _:b441737279 "2"^^ . _:b441736844 . _:b441737308 . _:b441736845 . _:b441736846 . _:b441736847 . _:b441737278 "2"^^ . _:b441736840 . . _:b441736841 . _:b441736842 . _:b441736843 . _:b441737273 "2"^^ . _:b441736852 . _:b441736853 . _:b441736854 . _:b441736855 . _:b441737272 "2"^^ . . _:b441736848 . _:b441736849 . _:b441736850 . _:b441736851 . _:b441737275 "2"^^ . _:b441736775 . _:b441736860 . _:b441736861 . . _:b441736862 . _:b441736863 . _:b441737274 "2"^^ . . _:b441736856 . . _:b441736857 . _:b441736858 . . _:b441736859 . _:b441737285 "2"^^ . _:b441736868 . _:b441736869 . . _:b441736870 . _:b441736871 . _:b441737284 "2"^^ . _:b441736864 . _:b441737453 . _:b441736865 . _:b441736866 . _:b441736867 . _:b441737287 "2"^^ . . _:b441736876 . _:b441736877 . _:b441736878 . _:b441737687 . _:b441737334 . . _:b441736879 . _:b441737286 "2"^^ . _:b441736872 . . _:b441736873 . . _:b441736874 . _:b441736875 . _:b441737281 "2"^^ . _:b441736884 . _:b441736784 . _:b441736885 . _:b441736886 . _:b441737470 . . _:b441736887 . _:b441737280 "2"^^ . _:b441736880 . _:b441736881 . _:b441737056 . _:b441736882 . _:b441736883 . _:b441737689 . _:b441737283 "2"^^ . _:b441736892 . _:b441736893 . _:b441736989 . _:b441736894 . _:b441736895 . _:b441737282 "2"^^ . _:b441736888 . _:b441737036 . _:b441736889 . _:b441736890 . _:b441736891 . _:b441737293 "2"^^ . _:b441736900 . _:b441737681 . _:b441736773 . . _:b441736901 . _:b441736902 . _:b441736903 . _:b441737292 "2"^^ . _:b441736896 . _:b441737542 . _:b441736897 . _:b441736898 . _:b441736899 . _:b441737295 "2"^^ . _:b441736908 . _:b441737647 . _:b441736909 . _:b441736826 . _:b441736910 . _:b441737254 . _:b441736911 . _:b441737294 "2"^^ . _:b441736904 . _:b441736905 . _:b441737390 . _:b441736906 . . _:b441737289 "2"^^ . _:b441736907 . _:b441736916 . _:b441736917 . _:b441736918 . _:b441736919 . _:b441737288 "2"^^ . _:b441736912 . _:b441736913 . _:b441736914 . . _:b441736915 . _:b441737291 "2"^^ . _:b441736924 . _:b441736925 . . _:b441736926 . _:b441736927 . _:b441737290 "2"^^ . _:b441736920 . _:b441736921 . _:b441736922 . _:b441736923 . _:b441737301 "2"^^ . _:b441736932 . _:b441736933 . _:b441736934 . _:b441736867 . _:b441736935 . _:b441737300 "2"^^ . _:b441737005 . _:b441736928 . _:b441736929 . _:b441736962 . _:b441736930 . _:b441736931 . _:b441737624 . _:b441737303 "2"^^ . _:b441736940 . _:b441736941 . . _:b441736942 . _:b441736943 . _:b441737302 "2"^^ . _:b441736936 . _:b441737489 . _:b441736937 . _:b441736938 . _:b441737132 . . _:b441736939 . _:b441737297 "2"^^ . _:b441737001 . _:b441736948 . _:b441736949 . . _:b441737367 . . _:b441736950 . _:b441736951 . _:b441737296 "2"^^ . _:b441736944 . _:b8585409 . _:b441736945 . _:b441736946 . _:b441736947 . _:b441737299 "2"^^ . . _:b441736757 . . _:b441736956 . _:b441736957 . _:b441736958 . _:b441737610 . _:b441736959 . _:b441737298 "2"^^ . _:b441737234 . _:b441736952 . _:b441737525 . . _:b441736953 . _:b441736954 . _:b441736955 . _:b441737309 "2"^^ . . _:b441737308 "2"^^ . _:b441737292 . . _:b441737319 . _:b441737233 . _:b441737311 "2"^^ . . _:b441737143 . . _:b441737310 "2"^^ . _:b441737305 "2"^^ . . . _:b441737304 "2"^^ . _:b441737307 "2"^^ . _:b8585396 "This is caused by differences in the cytokine, chemokine and growth factor production of tumour cells that determines the specific microenvironments [>>42<<,43]. To determine which patients may benefit from celecoxib treatment alone or in combination with immunotherapy, more research is needed." . . _:b441737306 "2"^^ . _:b441737141 . _:b441737146 . . _:b441737317 "2"^^ . . _:b441737316 "2"^^ . . _:b441737578 . . . _:b441737319 "2"^^ . _:b441737450 . . _:b441737318 "2"^^ . _:b441737313 "2"^^ . _:b441737739 . _:b441737312 "2"^^ . . _:b441737507 . _:b441737315 "2"^^ . _:b441737623 . _:b441737103 . _:b441737314 "2"^^ . . _:b441737325 "2"^^ . _:b441736916 . _:b441737324 "2"^^ . . _:b441737327 "2"^^ . . _:b441737165 . _:b441737326 "2"^^ . . _:b441737321 "2"^^ . _:b441736776 . . _:b441737320 "2"^^ . _:b441736995 . . _:b441737323 "2"^^ . _:b441737085 . . _:b441736797 . _:b441737400 . _:b441736949 . _:b441737322 "2"^^ . _:b441737333 "2"^^ . . _:b441737553 . _:b441736927 . _:b441737332 "2"^^ . _:b441737379 . _:b441737335 "2"^^ . _:b441737334 "2"^^ . _:b441737567 . . _:b441737329 "2"^^ . _:b441737328 "2"^^ . _:b441737331 "2"^^ . . _:b441737330 "2"^^ . . . _:b441736931 . _:b441737341 "2"^^ . _:b441737536 . _:b441737340 "2"^^ . _:b8585396 . . _:b441736800 . _:b441737343 "2"^^ . _:b441737134 . _:b441737664 . _:b441737342 "2"^^ . _:b441736897 . . . _:b441737337 "2"^^ . . _:b441737336 "2"^^ . . _:b8585382 . _:b441737339 "2"^^ . _:b8585367 . _:b441737338 "2"^^ . _:b441736982 . . _:b8585386 "It is also possible that the inhibitory effect of celecoxib on the NF\u03BAB pathway results in a reduced production of COX-2 proteins [>>35<<]. The reduction in COX-2 expression was accompanied by a reduction of PGE2 levels in peritoneal wash of celecoxib treated mice. Unfortunately no clear division can be made between the MDSC types in tumour tissue. Since Gr-1 (Ly6g) and" . _:b441737349 "2"^^ . . _:b441737348 "2"^^ . _:b441737351 "2"^^ . _:b441737108 . _:b441737350 "2"^^ . _:b441736943 . _:b8585372 . . . _:b441737345 "2"^^ . _:b8585373 . _:b441737344 "2"^^ . _:b8585374 . . _:b441737656 . _:b441737347 "2"^^ . . _:b8585375 . _:b441737346 "2"^^ . . _:b8585368 . . _:b441737644 . _:b441737357 "2"^^ . . . _:b8585369 . _:b441737356 "2"^^ . _:b8585405 . _:b8585370 . _:b441737359 "2"^^ . . _:b8585371 . _:b441737358 "2"^^ . _:b8585380 . . _:b441737353 "2"^^ . _:b441737104 . _:b441737388 . _:b8585381 . _:b441737352 "2"^^ . _:b441737658 . . _:b8585382 . . _:b441737355 "2"^^ . _:b8585383 . _:b441737354 "2"^^ . . . _:b8585376 . _:b441737365 "2"^^ . _:b441737548 . _:b441737371 . _:b8585377 . _:b441737364 "2"^^ . . _:b8585378 . _:b441737367 "2"^^ . _:b441737110 . _:b441737293 . . _:b8585379 . _:b441737366 "2"^^ . . _:b441737493 . _:b8585388 . _:b441737361 "2"^^ . _:b8585389 . _:b441737360 "2"^^ . _:b441737024 . _:b8585390 . . _:b441737363 "2"^^ . _:b8585391 . _:b441737164 . _:b441737362 "2"^^ . . _:b8585384 . _:b441737373 "2"^^ . . _:b8585385 . _:b441736905 . _:b441737372 "2"^^ . _:b8585394 . _:b8585380 . _:b8585386 . _:b441737375 "2"^^ . _:b441737570 . . _:b8585387 . _:b441736753 . _:b441737374 "2"^^ . . . _:b8585402 . _:b8585396 . . _:b441737369 "2"^^ . _:b8585397 . . _:b441737368 "2"^^ . . _:b441737510 . . _:b441737371 "2"^^ . _:b8585398 . _:b8585399 . _:b441737370 "2"^^ . . _:b8585392 . . _:b441737381 "2"^^ . _:b441736957 . _:b8585393 . _:b441737380 "2"^^ . _:b441737149 . _:b8585394 . _:b441737383 "2"^^ . . _:b8585395 . _:b441737382 "2"^^ . . _:b8585404 . . _:b441737377 "2"^^ . . _:b441737694 . _:b8585405 . _:b441737376 "2"^^ . . _:b8585406 . _:b441737379 "2"^^ . . _:b8585409 "Increased evidence indicates that immune suppressive cells, recruited by tumour-derived factors, are the main cause of failure of novel anti-cancer therapies, including immunotherapy [>>4<<,19-24]. We investigated dendritic cell (DC)-based immunotherapy in a murine model of mesothelioma." . _:b8585407 . _:b441737378 "2"^^ . _:b8585400 . _:b441737389 "2"^^ . _:b441736774 . _:b8585401 . _:b441737388 "2"^^ . _:b441737243 . _:b441737522 . _:b8585402 . _:b441737391 "2"^^ . _:b441737464 . . . _:b8585403 . _:b441737390 "2"^^ . _:b441737631 . _:b8585412 . _:b441737385 "2"^^ . . _:b441737476 . _:b441737245 . _:b441737384 "2"^^ . . _:b441737387 "2"^^ . _:b441737386 "2"^^ . . _:b441737260 . _:b441737387 . _:b441737496 . _:b8585408 . _:b441737397 "2"^^ . _:b8585409 . _:b441737396 "2"^^ . . . _:b441737434 . . _:b8585410 . . _:b441737399 "2"^^ . . _:b8585411 . _:b441737398 "2"^^ . . _:b8585375 "However, the effectiveness of the anti-tumour response was negatively influenced when tumours sizes increased [>>28<<]. It has been addressed that one of the main reasons for immunotherapy failure is the induction of T cell tolerance by immune suppressive cells. To determine if treatment with celecoxib also intercepts the induction of T cell tolerance" . _:b441737393 "2"^^ . _:b441737608 . _:b8585373 . _:b441737392 "2"^^ . . _:b441737395 "2"^^ . . . _:b441737394 "2"^^ . . . _:b441737515 . _:b441737405 "2"^^ . . _:b441737404 "2"^^ . _:b441737407 "2"^^ . . . . _:b441737406 "2"^^ . _:b441737176 . _:b441737401 "2"^^ . _:b441737123 . _:b441737094 . _:b441737400 "2"^^ . . _:b8585368 . . _:b441737403 "2"^^ . . _:b441737058 . _:b8585369 . _:b441737402 "2"^^ . _:b441737565 . _:b441737413 "2"^^ . . _:b441737698 . _:b441737412 "2"^^ . . _:b441737415 "2"^^ . _:b441736958 . _:b441737109 . . _:b441736947 . _:b441737414 "2"^^ . . _:b441737026 . _:b441737409 "2"^^ . . . _:b441737408 "2"^^ . . _:b441737411 "2"^^ . . _:b441737410 "2"^^ . _:b441736805 . _:b441737421 "2"^^ . _:b441737420 "2"^^ . . . _:b441736789 . _:b441737423 "2"^^ . . . _:b441737422 "2"^^ . _:b8585377 "The occurrence of tumour growth, body weight, physical well-being and survival were measured for 2 months, as described previously [>>28<<]." . . . _:b441737417 "2"^^ . _:b441737554 . . _:b441737416 "2"^^ . _:b441737116 . _:b441737419 "2"^^ . _:b441737501 . _:b441736752 . . _:b441737418 "2"^^ . _:b441736965 . . . . _:b441737429 "2"^^ . _:b441736952 . _:b441736863 . _:b441737428 "2"^^ . . _:b441737431 "2"^^ . _:b8585381 "Previous studies showed that ROS production by MDSC is the main factor for inducing T cell tolerance by down regulation of the \u03B6-chain on activated T cells [>>19<<,30]. Celecoxib-treatment especially influenced this PMN-MDSC population compared to other MDSC subtypes in the spleen of tumour-bearing mice. Greifenberg et. al. recently showed that this population was not capable of NO production and" . . _:b441736795 . _:b441737430 "2"^^ . . _:b441737425 "2"^^ . _:b441736911 . _:b441736983 . . _:b441737257 . _:b441737424 "2"^^ . _:b441737273 . _:b441737427 "2"^^ . _:b441737426 "2"^^ . _:b441737220 . _:b441737039 . _:b441737437 "2"^^ . _:b441736763 . . _:b441737436 "2"^^ . _:b441737685 . _:b441737040 . _:b441737439 "2"^^ . . _:b441737605 . . . _:b441737438 "2"^^ . . _:b441737139 . . . _:b441737433 "2"^^ . _:b441737432 "2"^^ . _:b441737435 "2"^^ . _:b441737434 "2"^^ . . . . _:b441737445 "2"^^ . . _:b441737444 "2"^^ . . _:b441737418 . _:b441737329 . _:b441737447 "2"^^ . . _:b441737336 . _:b441737446 "2"^^ . . _:b8585389 "Same results were reported by others [>>37<<]. We were not able to verify that the improvement of the anti-tumour response in tumour-bearing mice treated with celecoxib was directly caused by the reduction in MDSC." . _:b441737030 . _:b441737441 "2"^^ . _:b441736953 . _:b441737305 . . _:b441737440 "2"^^ . . . _:b441737701 . _:b441737443 "2"^^ . . _:b441736817 . _:b441737442 "2"^^ . _:b441737238 . _:b441737453 "2"^^ . . _:b441737452 "2"^^ . . . _:b441737455 "2"^^ . _:b441737454 "2"^^ . _:b441737711 . _:b441737706 . _:b441737449 "2"^^ . _:b441737524 . _:b441736825 . _:b441737448 "2"^^ . _:b8585397 . _:b441737451 "2"^^ . . . _:b441737450 "2"^^ . _:b441736898 . . _:b441737580 . _:b441737461 "2"^^ . . _:b441737460 "2"^^ . _:b441736950 . _:b441737463 "2"^^ . . _:b441737078 . _:b441737462 "2"^^ . _:b441737457 "2"^^ . . _:b441736755 . _:b441736818 . _:b441737456 "2"^^ . . . _:b441737459 "2"^^ . _:b441737307 . . . . _:b441737458 "2"^^ . . . _:b441737469 "2"^^ . _:b441737573 . . _:b441737468 "2"^^ . _:b441737361 . _:b441737471 "2"^^ . _:b441737470 "2"^^ . _:b441737465 "2"^^ . . . . _:b441737464 "2"^^ . _:b441737467 "2"^^ . _:b441737472 . _:b441737722 . _:b441737466 "2"^^ . _:b441737477 "2"^^ . . _:b441737476 "2"^^ . _:b441737622 . _:b441737479 "2"^^ . _:b441737592 . . _:b441737253 . . _:b441737478 "2"^^ . . _:b441737673 . _:b441737473 "2"^^ . . _:b441737472 "2"^^ . _:b441737591 . _:b441737475 "2"^^ . _:b441736884 . _:b441737474 "2"^^ . . . _:b441737485 "2"^^ . _:b441736936 . _:b441737484 "2"^^ . _:b441736856 . _:b441737487 "2"^^ . _:b441737486 "2"^^ . _:b441737504 . _:b441737481 "2"^^ . _:b441737480 "2"^^ . _:b441736963 . . _:b441737483 "2"^^ . . _:b441737482 "2"^^ . . _:b441737493 "2"^^ . _:b441737492 "2"^^ . _:b441737066 . _:b441737495 "2"^^ . . . _:b441737494 "2"^^ . . _:b441737489 "2"^^ . _:b441737488 "2"^^ . . . _:b441737491 "2"^^ . _:b441737490 "2"^^ . . _:b441737501 "2"^^ . _:b441737500 "2"^^ . . . . _:b441737503 "2"^^ . _:b441737502 "2"^^ . _:b441737235 . _:b441737497 "2"^^ . . _:b441737496 "2"^^ . . _:b441737499 "2"^^ . _:b441737498 "2"^^ . . . _:b441737509 "2"^^ . _:b441737564 . . _:b441737508 "2"^^ . _:b441737511 "2"^^ . _:b441737510 "2"^^ . . _:b441737505 "2"^^ . . _:b441736913 . _:b441737504 "2"^^ . . _:b441737507 "2"^^ . . _:b441737436 . _:b441737506 "2"^^ . _:b441737422 . _:b441737517 "2"^^ . . _:b441736967 . _:b441737516 "2"^^ . _:b441737751 . _:b441737519 "2"^^ . _:b441737518 "2"^^ . _:b441736965 . _:b441737144 . _:b441736955 . _:b441737513 "2"^^ . _:b441736964 . _:b441737654 . _:b8585400 "These cells can inhibit anti-tumour responses in an antigen-specific and in a non-specific way [1,>>2<<]. Antigen-specific suppression takes place in lymphoid organs and depends on reactive oxygen species (ROS) production, leading to T cell tolerance. Antigen-non-specific suppression takes place at the tumour site and is mainly dependent on" . . _:b441736858 . _:b441737512 "2"^^ . _:b441736967 . _:b441737696 . _:b441737515 "2"^^ . _:b441736966 . . _:b441737152 . _:b441737514 "2"^^ . _:b441736961 . _:b441737525 "2"^^ . _:b441736960 . . . "PMC0" . _:b441737511 . _:b441737524 "2"^^ . _:b441736963 . . _:b441737527 "2"^^ . _:b441736962 . _:b441736999 . _:b441737102 . . . _:b441737526 "2"^^ . _:b441736973 . _:b441737205 . . _:b441737521 "2"^^ . _:b441736972 . . _:b441737520 "2"^^ . _:b441736975 . . _:b441737251 . _:b441737523 "2"^^ . _:b441737549 . _:b441736974 . _:b441737204 . . _:b441737522 "2"^^ . _:b8585406 . _:b441736969 . _:b441737533 "2"^^ . _:b441736968 . . _:b441737611 . . _:b441737532 "2"^^ . _:b441736971 . . _:b441737070 . _:b441737535 "2"^^ . _:b441736970 . . _:b441737113 . _:b441737534 "2"^^ . _:b441736981 . _:b441737529 "2"^^ . _:b441736980 . . _:b441737528 "2"^^ . _:b441736983 . _:b441737734 . . . . _:b441737531 "2"^^ . . _:b441736982 . _:b441737530 "2"^^ . _:b441736977 . . _:b441737541 "2"^^ . _:b441737214 . . . _:b441736976 . _:b441737259 . _:b441737540 "2"^^ . _:b441736979 . _:b441737090 . _:b441737454 . _:b441736794 . . _:b441737543 "2"^^ . _:b441736978 . . _:b441737158 . . _:b441737542 "2"^^ . _:b441736989 . _:b441736771 . . . _:b441737612 . _:b441737537 "2"^^ . . _:b441736988 . _:b441737498 . _:b441737596 . _:b441737536 "2"^^ . _:b441736991 . _:b441737575 . _:b441737539 "2"^^ . _:b441736990 . _:b441737538 "2"^^ . _:b441736985 . . _:b441736815 . _:b441737549 "2"^^ . _:b441736984 . _:b441737548 "2"^^ . _:b441736987 . . _:b441737551 "2"^^ . _:b441736986 . _:b441737284 . . _:b441737550 "2"^^ . _:b441736997 . . _:b441736890 . _:b441737545 "2"^^ . _:b441736996 . _:b441737544 "2"^^ . _:b441736999 . _:b441737547 "2"^^ . _:b441736998 . _:b441737424 . _:b441737546 "2"^^ . _:b441736993 . _:b441737671 . . _:b441737557 "2"^^ . _:b441736992 . _:b441737042 . _:b441737374 . . _:b441737067 . _:b441737556 "2"^^ . _:b441736995 . _:b441737590 . _:b441737192 . _:b441737559 "2"^^ . _:b441736994 . _:b441737221 . . _:b441737558 "2"^^ . _:b441737005 . _:b441737754 . _:b441737679 . _:b441737553 "2"^^ . _:b441737004 . _:b441736787 . _:b441737048 . _:b441737552 "2"^^ . _:b441737007 . . _:b441737555 "2"^^ . _:b441737006 . _:b441737554 "2"^^ . _:b441736866 . _:b441737001 . _:b441737565 "2"^^ . _:b441737614 . _:b441737000 . _:b441737564 "2"^^ . _:b441737003 . . _:b441737567 "2"^^ . _:b441737002 . . . _:b441737566 "2"^^ . _:b441737013 . . _:b8585388 . _:b441737561 "2"^^ . _:b441737012 . _:b441736810 . _:b441737560 "2"^^ . _:b441737015 . . . _:b441737460 . _:b441737563 "2"^^ . _:b441737014 . . . _:b441737562 "2"^^ . _:b441737009 . _:b441737573 "2"^^ . _:b441737008 . _:b441737613 . _:b441737572 "2"^^ . _:b441737011 . . _:b441737575 "2"^^ . . _:b441737267 . _:b441737010 . _:b441737574 "2"^^ . _:b441737021 . . _:b441736972 . . _:b441737569 "2"^^ . _:b441736928 . _:b441737020 . . _:b441737568 "2"^^ . _:b441737023 . . _:b441737571 "2"^^ . _:b441737022 . _:b441737111 . _:b441737733 . _:b441737570 "2"^^ . _:b441737017 . . _:b441737581 "2"^^ . _:b441737016 . _:b8585377 . _:b441737580 "2"^^ . _:b441737019 . _:b441736923 . _:b441737335 . . _:b441737583 "2"^^ . _:b441737018 . _:b441736807 . . _:b441737582 "2"^^ . _:b441737029 . _:b441737063 . _:b441737577 "2"^^ . _:b441737028 . _:b441737551 . _:b441736820 . _:b441737576 "2"^^ . _:b441737031 . _:b441736971 . _:b441737138 . . _:b441737579 "2"^^ . _:b441737030 . . _:b441737578 "2"^^ . . _:b441737025 . . _:b441737750 . . _:b441737589 "2"^^ . _:b441737304 . _:b441737024 . _:b441737588 "2"^^ . _:b441737027 . _:b441737468 . . _:b441737591 "2"^^ . . _:b441737026 . . _:b441737590 "2"^^ . . _:b441737037 . _:b441737746 . _:b441737313 . _:b441737713 . _:b441736783 . . _:b441737585 "2"^^ . _:b441737036 . _:b441737584 "2"^^ . _:b441737646 . _:b441737039 . . . _:b441737587 "2"^^ . _:b441737038 . . _:b441737586 "2"^^ . . _:b441737033 . _:b441737539 . . _:b441737389 . _:b441737597 "2"^^ . _:b441737032 . _:b441737596 "2"^^ . _:b441737035 . . _:b441737550 . _:b441737599 "2"^^ . _:b441737034 . _:b441737717 . _:b441737598 "2"^^ . _:b441737045 . _:b441737675 . _:b441737593 "2"^^ . _:b441737044 . _:b441737324 . _:b441737592 "2"^^ . _:b441736804 . _:b441737047 . . _:b441736873 . _:b441737595 "2"^^ . _:b441737046 . . _:b441737286 . _:b441737594 "2"^^ . _:b441737041 . . . _:b441737356 . _:b441737605 "2"^^ . _:b441737040 . _:b441736853 . _:b441737604 "2"^^ . _:b441737043 . _:b441737246 . _:b441736906 . _:b441737607 "2"^^ . . _:b441737042 . . _:b441737606 "2"^^ . _:b441737053 . . . _:b441737601 "2"^^ . . _:b441737052 . . . _:b441737600 "2"^^ . _:b441737055 . _:b441737396 . _:b441737603 "2"^^ . _:b441737054 . _:b441737213 . . _:b441736871 . _:b441737602 "2"^^ . _:b441737049 . _:b441737613 "2"^^ . _:b441737048 . _:b441737612 "2"^^ . _:b441737051 . _:b441737595 . _:b8585374 . . _:b441737615 "2"^^ . . _:b441737050 . _:b441737557 . _:b8585375 . _:b441737614 "2"^^ . _:b441737061 . _:b441736979 . _:b441737609 "2"^^ . _:b441737060 . . . _:b441737608 "2"^^ . _:b441737063 . _:b441737393 . _:b441737726 . _:b441737569 . _:b441737611 "2"^^ . _:b441737062 . _:b441737610 "2"^^ . . _:b8585410 . _:b441737057 . _:b441737621 "2"^^ . _:b8585372 "It has been shown that MDSC can down regulated the \u03B6-chain on T cells by ROS production in the lymphoid organs and thereby induce T cell tolerance [>>19<<,30]. We analyzed splenocytes of dietary celecoxib treated and untreated mice for their capability to produce ROS." . _:b441737056 . _:b441737546 . . _:b441737620 "2"^^ . . _:b441737059 . _:b441737623 "2"^^ . _:b441737058 . _:b441737622 "2"^^ . _:b441737069 . . _:b441737617 "2"^^ . . _:b441737068 . _:b441737616 "2"^^ . _:b441737071 . _:b441737619 "2"^^ . . _:b441737070 . . _:b441737618 "2"^^ . _:b441737065 . . . _:b441737629 "2"^^ . . _:b441737733 . _:b441737064 . _:b441737628 "2"^^ . _:b441737067 . _:b441737732 . _:b441737051 . _:b441737631 "2"^^ . _:b441737066 . _:b441737735 . . _:b441737397 . _:b441737630 "2"^^ . _:b441737077 . _:b441737734 . . _:b441737625 "2"^^ . _:b441737076 . _:b441737729 . . . _:b441736752 "36"^^ . _:b441737624 "2"^^ . _:b441737079 . _:b441737728 . _:b441737627 "2"^^ . _:b441737078 . _:b441737731 . _:b441737626 "2"^^ . _:b441737073 . _:b441737730 . _:b441737191 . _:b441737637 "2"^^ . _:b441737072 . _:b441737741 . _:b441736754 "26"^^ . _:b441736948 . . _:b441737636 "2"^^ . _:b441736755 "25"^^ . _:b441737740 . _:b441737114 . _:b441737075 . _:b441736753 "26"^^ . _:b441737131 . _:b441737297 . _:b441737639 "2"^^ . _:b441737074 . _:b441737743 . _:b8585386 . . . _:b441737638 "2"^^ . . _:b441737085 . _:b441737742 . . _:b441737633 "2"^^ . _:b441737678 . _:b441736757 "21"^^ . _:b8585412 . _:b441737737 . _:b441737084 . _:b441737145 . _:b441737632 "2"^^ . _:b441737087 . _:b441737736 . _:b441736759 "18"^^ . _:b441736756 "22"^^ . _:b441737270 . _:b441737635 "2"^^ . _:b441737086 . _:b441737739 . _:b441736758 "20"^^ . _:b441737634 "2"^^ . _:b441737081 . _:b441737738 . _:b441737077 . _:b441737352 . . _:b441737645 "2"^^ . _:b441737080 . _:b441737749 . _:b441736760 "18"^^ . _:b441737122 . _:b441737756 . _:b441737327 . _:b441737672 . _:b441737644 "2"^^ . . _:b441737748 . _:b441737083 . _:b441736761 "17"^^ . _:b441736762 "16"^^ . _:b8585389 . _:b441737647 "2"^^ . . _:b441737751 . _:b441737415 . _:b441737082 . . _:b441736763 "16"^^ . _:b441737646 "2"^^ . _:b441737093 . _:b441737750 . _:b441736764 "16"^^ . _:b441737641 "2"^^ . _:b441737092 . _:b441737745 . _:b441736765 "16"^^ . _:b441737640 "2"^^ . _:b441737095 . _:b441737744 . _:b441737704 . _:b441736766 "15"^^ . _:b441737643 "2"^^ . _:b441737094 . _:b441737747 . _:b441737416 . _:b441736767 "15"^^ . _:b441737642 "2"^^ . _:b441737089 . _:b441737749 . _:b441737746 . . _:b441736768 "15"^^ . _:b441737653 "2"^^ . . _:b441737757 . _:b441737088 . _:b441736769 "14"^^ . _:b441737652 "2"^^ . _:b441737091 . _:b441737756 . _:b441736770 "14"^^ . _:b441736812 . . _:b441737655 "2"^^ . _:b441737090 . _:b441737759 . _:b441736793 . _:b8585397 "This is caused by differences in the cytokine, chemokine and growth factor production of tumour cells that determines the specific microenvironments [42,>>43<<]. To determine which patients may benefit from celecoxib treatment alone or in combination with immunotherapy, more research is needed." . _:b441736771 "14"^^ . _:b441737654 "2"^^ . _:b441737101 . _:b441737758 . _:b441736991 . _:b441736772 "14"^^ . . _:b441737649 "2"^^ . . _:b441737753 . _:b441737100 . _:b441736773 "14"^^ . . _:b441737648 "2"^^ . _:b441736878 . _:b441737752 . _:b441737103 . _:b441736774 "14"^^ . . _:b441737651 "2"^^ . _:b441737102 . _:b441737755 . _:b441737345 . . _:b441736775 "14"^^ . _:b441737650 "2"^^ . _:b8585392 "For this reason COX-2 inhibition has been proposed as potential therapeutic target for mesothelioma [>>10<<,11]. Also PGE2 contributes to proliferation, survival, angiogenesis, migration and invasion of tumour cells [41]." . _:b441737097 . _:b441737754 . . _:b8585382 "Previous studies showed that ROS production by MDSC is the main factor for inducing T cell tolerance by down regulation of the \u03B6-chain on activated T cells [19,>>30<<]. Celecoxib-treatment especially influenced this PMN-MDSC population compared to other MDSC subtypes in the spleen of tumour-bearing mice. Greifenberg et. al. recently showed that this population was not capable of NO production and" . _:b441736783 "12"^^ . _:b441737661 "2"^^ . _:b441737486 . _:b441737096 . . _:b441736782 "12"^^ . _:b441737660 "2"^^ . _:b441736984 . _:b441737764 . _:b441737099 . _:b8585371 . _:b441736781 "12"^^ . _:b441737680 . _:b441737663 "2"^^ . _:b441737641 . . _:b441737098 . _:b441736842 . _:b441736780 "12"^^ . _:b441737662 "2"^^ . . _:b441737109 . _:b441736857 . _:b441737302 . _:b441737657 "2"^^ . _:b441737587 . _:b441736779 "13"^^ . _:b441737761 . _:b441737108 . _:b441737656 "2"^^ . _:b441736778 "13"^^ . _:b441737760 . _:b441737111 . . _:b441737659 "2"^^ . _:b441736777 "13"^^ . _:b441737763 . _:b441737110 . _:b441737018 . _:b441737658 "2"^^ . _:b441736776 "13"^^ . _:b441737762 . _:b441737105 . . _:b441736791 "11"^^ . _:b441737669 "2"^^ . _:b8585368 "Similar to the most recent published data, three populations of Gr-1+CD11b+ cells were identified [>>5<<-7]. The Gr-1low MDSC could be further subdivided in two populations based on size and inner complexity of the cells (forward [FSC]/side scatter [SSC])." . _:b441737104 . _:b441736790 "12"^^ . _:b441737668 "2"^^ . _:b441737107 . _:b441737585 . _:b441737282 . _:b441737503 . _:b441737692 . _:b441737544 . _:b441736789 "12"^^ . _:b441737671 "2"^^ . _:b441736837 . _:b441737106 . . _:b441737266 . _:b441736788 "12"^^ . _:b441737670 "2"^^ . _:b441737117 . _:b441736787 "12"^^ . _:b441737665 "2"^^ . _:b441737116 . _:b441736786 "12"^^ . _:b441737664 "2"^^ . _:b441737119 . _:b441737285 . _:b441736785 "12"^^ . _:b441737667 "2"^^ . _:b441737118 . _:b441736784 "12"^^ . _:b441737666 "2"^^ . _:b441737113 . _:b441736799 "10"^^ . _:b441737677 "2"^^ . _:b8585372 . _:b441737112 . _:b441736798 "11"^^ . _:b441737676 "2"^^ . _:b441737115 . _:b441736797 "11"^^ . . _:b441737679 "2"^^ . _:b441737002 . _:b441737114 . _:b441736796 "11"^^ . . _:b441737678 "2"^^ . . _:b441737401 . _:b441737125 . _:b441736795 "11"^^ . . _:b441737695 . _:b441737673 "2"^^ . _:b441737124 . . _:b441737296 . . _:b441736794 "11"^^ . . _:b441737672 "2"^^ . _:b441737127 . _:b441736793 "11"^^ . _:b441737675 "2"^^ . _:b441737126 . _:b441737626 . _:b8585406 "Therefore, high expression of COX-2 has been correlated with poor prognosis in cancer [>>10<<-12]. In addition, several studies showed the relevance of COX-2 inhibition in cancer progression [13-15]. Although the relation between COX-2 over-expression and prostaglandin E2 (PGE2) synthesis in cancer has been studied extensively," . _:b441736792 "11"^^ . _:b441737674 "2"^^ . _:b441737121 . . _:b441736807 "10"^^ . _:b441737287 . _:b441737685 "2"^^ . _:b441737120 . . _:b441737721 . _:b441737709 . _:b441736806 "10"^^ . _:b441737438 . _:b441737684 "2"^^ . _:b441737123 . . _:b441737382 . _:b441736805 "10"^^ . . _:b441737687 "2"^^ . _:b441736887 . _:b441737122 . . _:b441736804 "10"^^ . . . _:b441737686 "2"^^ . _:b441737133 . . _:b441736803 "10"^^ . . _:b441736758 . _:b441737681 "2"^^ . _:b441736961 . _:b441737047 . _:b441737132 . _:b441736802 "10"^^ . _:b441737082 . _:b441737680 "2"^^ . _:b441737135 . _:b441736986 . _:b441736801 "10"^^ . _:b441737491 . _:b441737683 "2"^^ . _:b441736822 . _:b441737134 . _:b441736800 "10"^^ . _:b8585394 "Also PGE2 contributes to proliferation, survival, angiogenesis, migration and invasion of tumour cells [>>41<<]." . . _:b441737682 "2"^^ . _:b441737091 . _:b441737129 . _:b8585376 "methods" . _:b441737693 "2"^^ . _:b441736814 "9"^^ . _:b441737128 . _:b8585401 "Antigen-non-specific suppression takes place at the tumour site and is mainly dependent on nitric oxide (NO) secretion, causing T cell specific apoptosis [>>2<<-4]. More recently, it has been shown that the heterogeneous group of MDSC can be subdivided into three major groups. Polymorph nuclei MDSC (PMN-MDSC), mononuclear MDSC (MO-MDSC) and Gr-1low MDSC [5-7]. Greifenberg et. al. showed that the" . _:b441737692 "2"^^ . _:b8585395 . _:b441736815 "9"^^ . _:b441737131 . _:b441737695 "2"^^ . _:b441736812 "9"^^ . _:b441737341 . _:b441737130 . _:b441737694 "2"^^ . _:b441736813 "9"^^ . _:b441737141 . . _:b441736811 "10"^^ . . _:b441737689 "2"^^ . _:b441737140 . _:b441736810 "10"^^ . . _:b441737693 . . _:b441737688 "2"^^ . _:b441737560 . _:b441737011 . _:b441737143 . _:b441737168 . _:b441736809 "10"^^ . . _:b441737691 "2"^^ . . . _:b441737142 . _:b441736808 "10"^^ . . _:b441737690 "2"^^ . _:b441737456 . . _:b441737137 . _:b441736822 "8"^^ . _:b441737701 "2"^^ . _:b441737136 . _:b441736823 "8"^^ . _:b441737700 "2"^^ . . _:b441737710 . _:b441737139 . _:b441736820 "8"^^ . _:b441737703 "2"^^ . _:b441737632 . _:b441737138 . _:b441736847 . _:b441736821 "8"^^ . _:b441737702 "2"^^ . _:b441737149 . _:b8585385 "It has been suggested that PGE2 functions as a feedback on COX-2 protein expression and that celecoxib inhibits this loop [>>34<<]. It is also possible that the inhibitory effect of celecoxib on the NF\u03BAB pathway results in a reduced production of COX-2 proteins [35]. The reduction in COX-2 expression was accompanied by a reduction of PGE2 levels in peritoneal wash" . . . _:b441737697 "2"^^ . _:b441736818 "9"^^ . _:b441737148 . _:b441737097 . . _:b8585391 . _:b441736922 . . . _:b441737696 "2"^^ . _:b441736819 "9"^^ . _:b441737151 . . . _:b441737699 "2"^^ . _:b441736816 "9"^^ . _:b441737354 . _:b441737150 . _:b441737252 . _:b441737698 "2"^^ . . _:b441737145 . _:b441736817 "9"^^ . . _:b441736830 "8"^^ . _:b441737709 "2"^^ . _:b441737144 . _:b441737556 . _:b441736831 "8"^^ . _:b441737708 "2"^^ . _:b441737147 . _:b441736828 "8"^^ . _:b441737711 "2"^^ . _:b441737661 . _:b441736990 . _:b441737146 . _:b441736946 . _:b441737710 "2"^^ . _:b441736829 "8"^^ . . _:b441737157 . _:b441736826 "8"^^ . _:b441737705 "2"^^ . _:b441737156 . _:b441736827 "8"^^ . _:b441737704 "2"^^ . _:b441737159 . _:b441737106 . _:b441736824 "8"^^ . _:b441737707 "2"^^ . _:b441736879 . _:b441737349 . _:b441737158 . . . . _:b8585381 . _:b441737706 "2"^^ . _:b441736825 "8"^^ . . _:b441737153 . _:b441737359 . _:b441736838 "8"^^ . _:b441737717 "2"^^ . _:b441737152 . . _:b441736839 "7"^^ . _:b441737309 . _:b441737716 "2"^^ . _:b441737155 . . _:b441737719 "2"^^ . _:b441736836 "8"^^ . . _:b441737154 . _:b441736837 "8"^^ . _:b441737718 "2"^^ . _:b441737165 . _:b441736908 . _:b441736834 "8"^^ . _:b441737713 "2"^^ . _:b441737164 . _:b441737495 . . _:b441737667 . _:b441736765 . _:b441736835 "8"^^ . _:b441737712 "2"^^ . . _:b441737167 . _:b441737677 . . _:b441737715 "2"^^ . _:b441736832 "8"^^ . _:b441736977 . _:b441737166 . . _:b441737248 . _:b441736833 "8"^^ . _:b441737714 "2"^^ . _:b441737161 . _:b441736846 "7"^^ . _:b441737725 "2"^^ . _:b441737038 . _:b441737572 . _:b441737160 . _:b441737593 . _:b441736930 . _:b441737708 . _:b441736847 "7"^^ . _:b441737724 "2"^^ . _:b441737163 . _:b441736844 "7"^^ . . _:b441737727 "2"^^ . _:b441737162 . _:b441736929 . _:b441736845 "7"^^ . . _:b441737726 "2"^^ . . _:b441737173 . . _:b441736842 "7"^^ . _:b441737721 "2"^^ . . _:b441737172 . _:b441736843 "7"^^ . _:b441737407 . _:b441737720 "2"^^ . _:b441737175 . . _:b441736840 "7"^^ . . _:b441737723 "2"^^ . _:b441736899 . _:b441737239 . _:b441737174 . _:b441736841 "7"^^ . _:b441737196 . _:b441737722 "2"^^ . _:b441737169 . _:b441737467 . _:b441736854 "7"^^ . . _:b441737168 . . _:b441736855 "7"^^ . _:b441737171 . . _:b441736852 "7"^^ . _:b441737735 . _:b441737170 . . _:b441737156 . _:b441736853 "7"^^ . _:b441737398 . . _:b441737181 . _:b441737421 . _:b441736850 "7"^^ . . _:b441737180 . _:b441736851 "7"^^ . . . _:b441737432 . _:b441737183 . _:b441736759 . . . _:b441736848 "7"^^ . . _:b441737637 . _:b441737182 . _:b441736849 "7"^^ . _:b441737177 . _:b441736862 "6"^^ . _:b441737045 . _:b441737435 . _:b441737176 . _:b441736863 "6"^^ . _:b441736998 . _:b441737093 . _:b441737179 . _:b441736860 "6"^^ . . _:b8585410 . _:b441737178 . _:b441737682 . _:b441736861 "6"^^ . _:b8585369 "Since COX-2 is an essential enzyme for catalyzing the biosynthesis of tumour-derived prostaglandin E2 (PGE2), a molecule that induces MDSC [>>7<<], biopsies were stained for COX-2 expression." . _:b441737499 . _:b441737189 . _:b441736886 . _:b441736858 "7"^^ . _:b441737240 . . _:b441737188 . _:b441736859 "6"^^ . _:b441737380 . . . _:b441737191 . _:b441736856 "7"^^ . _:b441736861 . _:b441737190 . _:b441736857 "7"^^ . _:b441737185 . _:b441736870 "6"^^ . . . _:b441737606 . . . _:b441737184 . _:b441736871 "6"^^ . _:b441737187 . _:b441736868 "6"^^ . _:b441737020 . . . _:b441737186 . _:b441736869 "6"^^ . _:b441737197 . _:b441737762 . _:b441736866 "6"^^ . . _:b441737196 . _:b441736867 "6"^^ . _:b441737753 . _:b441737199 . _:b441736864 "6"^^ . _:b441737198 . _:b441736865 "6"^^ . _:b441737193 . _:b441736878 "6"^^ . _:b441737192 . _:b441736879 "6"^^ . _:b441737195 . _:b441736876 "6"^^ . _:b441737194 . _:b441736877 "6"^^ . . . _:b441737205 . _:b441736874 "6"^^ . _:b441737545 . _:b441737627 . _:b441737568 . _:b441737204 . _:b441736875 "6"^^ . . . _:b441737207 . _:b441736872 "6"^^ . _:b441737172 . . _:b441737206 . _:b441737157 . _:b441736873 "6"^^ . . _:b441737060 . _:b441737201 . _:b441736886 "6"^^ . . _:b441737200 . _:b441737326 . _:b441736887 "6"^^ . _:b441737119 . _:b441736801 . _:b441737203 . _:b441736884 "6"^^ . . _:b441737202 . _:b441736885 "6"^^ . _:b441737213 . _:b441736882 "6"^^ . _:b441737212 . _:b441736883 "6"^^ . _:b441737015 . _:b441737054 . _:b441737215 . _:b441737249 . _:b441736880 "6"^^ . _:b441737068 . _:b441737745 . _:b441737214 . _:b441736881 "6"^^ . _:b441736993 . . _:b441737209 . _:b441737208 . . _:b441737100 . _:b441737211 . _:b441736892 "6"^^ . _:b441737403 . _:b441736824 . _:b441736895 "5"^^ . _:b441737210 . _:b441736893 "6"^^ . . _:b441736894 "5"^^ . _:b441736890 "6"^^ . _:b441736996 . _:b441736891 "6"^^ . . _:b441737514 . _:b441736888 "6"^^ . _:b441736889 "6"^^ . . _:b441736855 . . _:b441736901 "5"^^ . _:b441737731 . _:b441737306 . . _:b441736900 "5"^^ . . . _:b441736903 "5"^^ . _:b441736796 . . _:b441737445 . _:b441736902 "5"^^ . _:b441737231 . _:b441737448 . _:b441736897 "5"^^ . . _:b8585412 "Adjacent to this, it was found that COX-2 over-expression in mesothelioma correlates with poor prognosis [>>26<<]. Combining the current knowledge on MDSC, COX-2 over-expression and immune suppression, we aimed to determine the effect of selective COX-2 inhibition on MDSC populations in the optimization of DC-based immunotherapy. We studied the" . _:b8585411 . _:b441736896 "5"^^ . _:b441736899 "5"^^ . _:b441736898 "5"^^ . . _:b441737083 . _:b441736909 "5"^^ . . . _:b441736908 "5"^^ . _:b441736911 "5"^^ . _:b441737312 . . _:b441736910 "5"^^ . _:b441737188 . _:b441736905 "5"^^ . _:b441737736 . . _:b441736904 "5"^^ . _:b441737215 . _:b441737715 . _:b441736907 "5"^^ . _:b441737485 . _:b8585387 "Ochoa and colleagues have suggested that prostaglandin E2 produced by tumour cells induced the arginase I expression in MDSC [>>36<<]. For this reason, COX-2 inhibition to reduce MDSC in number and function has been proposed as promising strategy to improve immunotherapy. We have previously shown that upon injection of antigen-loaded DCs an effective immune response" . . _:b8585410 . _:b441736906 "5"^^ . _:b441737340 . _:b441736917 "5"^^ . _:b441736916 "5"^^ . . . _:b441736919 "5"^^ . . . _:b441736918 "5"^^ . . _:b441737071 . _:b441736913 "5"^^ . . _:b441736912 "5"^^ . .