_:b446361603 "4"^^ . _:b446361602 "4"^^ . . _:b446361613 "4"^^ . _:b446361612 "4"^^ . . _:b446361615 "4"^^ . _:b446361614 "4"^^ . . _:b446361609 "4"^^ . _:b446363669 . _:b446361608 "4"^^ . _:b446361611 "4"^^ . _:b446362536 . _:b446364140 . . _:b446361610 "4"^^ . . _:b446364166 . _:b446362194 . _:b446361621 "4"^^ . _:b446364513 . _:b446361620 "4"^^ . _:b446362751 . _:b446361623 "4"^^ . _:b446361622 "4"^^ . _:b446361617 "4"^^ . . _:b446361961 . _:b446361616 "4"^^ . _:b446362144 . . _:b446361619 "4"^^ . _:b446361618 "4"^^ . _:b446361629 "4"^^ . . _:b446361628 "4"^^ . . _:b446361631 "4"^^ . _:b446361960 . _:b446361630 "4"^^ . _:b446361625 "4"^^ . _:b446364374 . _:b446363645 . _:b446361624 "4"^^ . _:b446360937 . . _:b446363006 . _:b446361627 "4"^^ . _:b9113976 "This program was approved by the Johns Hopkins institutional review board and deemed in accordance with the Health Insurance Portability and Accountability Act. Details of the program have been described in detail previously >>13<<. The tissue harvesting protocol consists of the following; after opening of the body cavity using standard techniques, the whole pancreas including the pancreatic cancer and each grossly identified metastasis were sampled using a sterile" . _:b446361626 "4"^^ . _:b446361637 "4"^^ . _:b446361636 "4"^^ . _:b446363032 . . _:b446364446 . _:b446361639 "4"^^ . . _:b446361638 "4"^^ . . _:b446363453 . _:b446361633 "4"^^ . _:b446363652 . _:b446361632 "4"^^ . . _:b446363121 . _:b446362006 . . _:b446361635 "4"^^ . . _:b446361634 "4"^^ . _:b446361645 "4"^^ . _:b446362741 . . _:b446363657 . _:b446361272 . _:b446361644 "4"^^ . _:b446361160 . . _:b446361945 . _:b446361647 "4"^^ . . _:b446361455 . _:b446361646 "4"^^ . . . . _:b446361641 "4"^^ . _:b446361640 "4"^^ . _:b446361643 "4"^^ . _:b446363294 . . . _:b446361642 "4"^^ . _:b446362750 . _:b446363313 . _:b446361653 "4"^^ . _:b446361652 "4"^^ . . _:b446361655 "4"^^ . _:b446362396 . . . _:b446361654 "4"^^ . _:b446362990 . _:b446361649 "4"^^ . . _:b446361648 "4"^^ . _:b446362641 . _:b446361651 "4"^^ . _:b446361650 "4"^^ . _:b446362398 . _:b446361506 . _:b446361661 "4"^^ . _:b446362173 . _:b446361660 "4"^^ . _:b446364291 . . _:b446361663 "4"^^ . . _:b446363742 . _:b446361662 "4"^^ . . _:b446361657 "4"^^ . . _:b446361625 . . _:b446362422 . _:b446361656 "4"^^ . . _:b9113989 _:b9113990 . _:b446363764 . _:b446360987 . _:b446361659 "4"^^ . _:b446363383 . _:b446361658 "4"^^ . . . _:b446361669 "4"^^ . . _:b446361668 "4"^^ . _:b446361750 . _:b446361671 "4"^^ . . _:b446361670 "4"^^ . . _:b446363262 . _:b446362044 . _:b446361665 "4"^^ . _:b446363979 . _:b446364500 . _:b446361664 "4"^^ . _:b446362455 . . _:b9113975 . _:b446361667 "4"^^ . _:b446360907 . . _:b446361666 "4"^^ . . _:b446361795 . _:b446363931 . _:b446361677 "4"^^ . . _:b446361676 "4"^^ . _:b446362834 . _:b446361679 "4"^^ . . _:b9113980 . _:b446361678 "4"^^ . _:b9113981 . _:b446360934 . _:b446361673 "4"^^ . _:b9113982 . _:b446361672 "4"^^ . _:b446362749 . _:b9113983 . . _:b446361675 "4"^^ . . _:b9113976 . _:b446361674 "4"^^ . . _:b9113977 . _:b446361280 . _:b446361685 "4"^^ . _:b446361702 . _:b9113978 . _:b446361684 "4"^^ . . _:b9113979 . _:b446361687 "4"^^ . . _:b9113988 . _:b446363497 . _:b446361686 "4"^^ . . . _:b9113989 . . _:b446361681 "4"^^ . _:b9113990 . _:b446361048 . _:b446361680 "4"^^ . _:b446361683 "4"^^ . _:b9113984 . _:b446362002 . _:b446361682 "4"^^ . _:b9113985 . . _:b446361693 "4"^^ . _:b9113986 . _:b446361692 "4"^^ . _:b446364611 . _:b446363091 . _:b9113987 . . _:b446361695 "4"^^ . . . _:b446361694 "4"^^ . . . _:b446361689 "4"^^ . . _:b446361688 "4"^^ . _:b446360877 . _:b446361691 "4"^^ . _:b446361690 "4"^^ . . . . _:b446361208 . _:b446361701 "4"^^ . _:b446362266 . _:b446363510 . _:b446361700 "4"^^ . . _:b446361703 "4"^^ . . _:b446361702 "4"^^ . . _:b446361714 . _:b446362440 . _:b446361697 "4"^^ . _:b446362244 . _:b446360917 . _:b446361696 "4"^^ . . . _:b446364405 . . _:b446363356 . _:b446364575 . _:b446361699 "4"^^ . _:b446364633 . _:b446361698 "4"^^ . _:b446361709 "4"^^ . _:b446361708 "4"^^ . . . _:b446361711 "4"^^ . . . _:b446361710 "4"^^ . "PMC0" . _:b446361705 "4"^^ . . _:b446363634 . _:b446361704 "4"^^ . . _:b446361707 "4"^^ . . _:b446361706 "4"^^ . _:b9113975 _:b9113976 . . _:b9113975 _:b9113977 . _:b446361717 "4"^^ . _:b9113975 _:b9113978 . _:b9113975 _:b9113979 . _:b9113975 _:b9113980 . _:b9113975 _:b9113981 . _:b446361716 "4"^^ . _:b9113975 _:b9113982 . _:b9113975 _:b9113983 . . _:b446361719 "4"^^ . _:b446361718 "4"^^ . . _:b446361458 . _:b446364619 . _:b446361713 "4"^^ . . _:b446361712 "4"^^ . _:b446361678 . _:b446363060 . _:b446361715 "4"^^ . _:b446363552 . _:b446361714 "4"^^ . . _:b446361076 . . _:b446361898 . _:b446361725 "4"^^ . . _:b446363426 . _:b446361724 "4"^^ . _:b446363745 . _:b446361727 "4"^^ . _:b446362658 . . _:b446361726 "4"^^ . . _:b446364139 . . _:b446361721 "4"^^ . . . . _:b446361720 "4"^^ . . . _:b446362394 . . _:b446361723 "4"^^ . . . _:b446361722 "4"^^ . _:b446361004 . _:b446363187 . _:b446361733 "4"^^ . . _:b446361732 "4"^^ . _:b446362642 . _:b446361735 "4"^^ . _:b446362839 . _:b446361734 "4"^^ . _:b446363905 . . _:b446361729 "4"^^ . . _:b446361728 "4"^^ . . _:b446363107 . _:b446361300 . _:b446361731 "4"^^ . _:b446361145 . _:b446361901 . _:b446361730 "4"^^ . _:b446361741 "4"^^ . _:b446361698 . _:b446363373 . _:b446361740 "4"^^ . . _:b446361743 "4"^^ . . . _:b446361742 "4"^^ . _:b446360994 . _:b446361737 "4"^^ . . _:b446361736 "4"^^ . _:b9113975 _:b9113984 . _:b9113975 _:b9113985 . _:b446361739 "4"^^ . _:b9113975 _:b9113986 . _:b9113975 _:b9113987 . _:b9113975 _:b9113988 . _:b446363482 . _:b446361738 "4"^^ . . _:b446363871 . _:b446361749 "4"^^ . _:b446364178 . _:b446361748 "4"^^ . _:b446362227 . _:b446361751 "4"^^ . . . _:b446361750 "4"^^ . . _:b446361745 "4"^^ . _:b446360855 . _:b446361744 "4"^^ . _:b446364213 . _:b446361747 "4"^^ . . _:b446361746 "4"^^ . . _:b446361757 "4"^^ . _:b446361485 . _:b446361756 "4"^^ . _:b446361759 "4"^^ . _:b446361887 . _:b446361758 "4"^^ . _:b446363732 . _:b446361753 "4"^^ . _:b446364369 . _:b446361752 "4"^^ . _:b446361755 "4"^^ . . _:b446364103 . _:b446361754 "4"^^ . . . _:b446362794 . . _:b446361765 "4"^^ . . . _:b446361942 . _:b446361764 "4"^^ . _:b446361246 . . . _:b446361767 "4"^^ . _:b446361932 . . _:b446361766 "4"^^ . _:b446361761 "4"^^ . _:b446362060 . _:b446360981 . _:b446363845 . _:b446361338 . . _:b446363977 . _:b446361760 "4"^^ . _:b446361763 "4"^^ . . _:b446361762 "4"^^ . . . . _:b446361773 "4"^^ . . _:b446361772 "4"^^ . . . _:b446361775 "4"^^ . _:b446361774 "4"^^ . . _:b446362789 . _:b446362502 . _:b446361769 "4"^^ . . _:b446361768 "4"^^ . _:b446363720 . . _:b446361771 "4"^^ . . _:b446362042 . _:b446363103 . _:b446361770 "4"^^ . _:b446360936 . _:b446361781 "4"^^ . _:b446361780 "4"^^ . _:b446362856 . _:b446363708 . _:b446361419 . _:b446361783 "4"^^ . . _:b446363046 . _:b446361782 "4"^^ . _:b446361777 "4"^^ . _:b446361776 "4"^^ . . _:b446363748 . _:b446361779 "4"^^ . _:b446361778 "4"^^ . _:b446361789 "4"^^ . _:b446362835 . _:b446361788 "4"^^ . . . . _:b446361791 "4"^^ . _:b446361790 "4"^^ . . . _:b446361785 "4"^^ . _:b446362104 . . _:b446361784 "4"^^ . . _:b446361787 "4"^^ . _:b446361786 "4"^^ . . _:b446361797 "4"^^ . . . _:b446361796 "4"^^ . _:b446362500 . . _:b446361581 . . _:b446362920 . _:b446361799 "4"^^ . . _:b446361798 "4"^^ . . _:b446361793 "4"^^ . _:b446361792 "4"^^ . _:b446363149 . _:b446361795 "4"^^ . _:b446363171 . . _:b446361794 "4"^^ . _:b446362726 . _:b446361805 "4"^^ . . _:b446361804 "4"^^ . . . _:b446361807 "4"^^ . _:b446361806 "4"^^ . _:b446361801 "4"^^ . _:b446362449 . _:b446360996 . _:b446361800 "4"^^ . . _:b446364124 . _:b446364527 . _:b446361803 "4"^^ . . _:b446361802 "4"^^ . . _:b446361813 "4"^^ . . _:b446362087 . _:b446361812 "4"^^ . _:b446362614 . _:b446361815 "4"^^ . _:b446362432 . _:b446361814 "4"^^ . . _:b446361809 "4"^^ . _:b446362556 . . _:b446361808 "4"^^ . _:b446364404 . _:b446362389 . _:b446361811 "4"^^ . . . _:b446364029 . _:b446361810 "4"^^ . _:b446361847 . _:b446361821 "4"^^ . _:b446362690 . _:b446363000 . _:b446361820 "4"^^ . _:b446363808 . _:b446362349 . _:b446361823 "4"^^ . _:b446363009 . _:b446361822 "4"^^ . _:b446361817 "4"^^ . . . _:b446361816 "4"^^ . . . . _:b446361819 "4"^^ . _:b446362861 . _:b446361818 "4"^^ . _:b446361829 "4"^^ . . . _:b446361828 "4"^^ . . . _:b446361831 "4"^^ . _:b446364359 . . _:b446361830 "4"^^ . . . _:b446361825 "4"^^ . . _:b446363036 . _:b446361824 "4"^^ . . _:b446361827 "4"^^ . _:b446364238 . . _:b446361826 "4"^^ . . _:b446361837 "3"^^ . _:b446361836 "3"^^ . . . _:b446361073 . _:b446361839 "3"^^ . _:b446361998 . . _:b446361838 "3"^^ . . _:b446361164 . _:b446361833 "4"^^ . . _:b446362278 . _:b446362599 . _:b446363150 . _:b446361832 "4"^^ . _:b446361835 "4"^^ . . _:b446364514 . _:b446361834 "4"^^ . _:b446364081 . . _:b446362803 . _:b446361845 "3"^^ . _:b446361844 "3"^^ . _:b446361792 . _:b446361847 "3"^^ . . _:b446361846 "3"^^ . . _:b446361841 "3"^^ . . _:b446362799 . _:b446361840 "3"^^ . _:b446362004 . _:b446361843 "3"^^ . . _:b446362444 . _:b446364371 . _:b446361162 . _:b446361842 "3"^^ . 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"3"^^ . _:b446361906 "3"^^ . _:b446364358 . _:b446361917 "3"^^ . . _:b446361916 "3"^^ . _:b446361269 . _:b446362826 . _:b446361919 "3"^^ . _:b446361260 . _:b446362019 . . _:b446361918 "3"^^ . _:b446363944 . . _:b446361913 "3"^^ . _:b446364271 . . . _:b446361012 . _:b446361912 "3"^^ . _:b446361682 . . _:b446362901 . _:b446361915 "3"^^ . _:b446363368 . _:b446363438 . _:b446361914 "3"^^ . _:b446361925 "3"^^ . _:b446361924 "3"^^ . . _:b446361927 "3"^^ . . _:b446361926 "3"^^ . _:b446361117 . _:b446361921 "3"^^ . . . _:b446361920 "3"^^ . _:b446364158 . _:b446361923 "3"^^ . _:b446361922 "3"^^ . . _:b446361933 "3"^^ . . _:b446361524 . _:b446364640 . _:b446360927 . _:b446361932 "3"^^ . . _:b446361935 "3"^^ . _:b446361482 . _:b446361934 "3"^^ . . _:b446362147 . . _:b446361929 "3"^^ . _:b446361928 "3"^^ . _:b446361931 "3"^^ . _:b446362458 . _:b446363387 . _:b446361930 "3"^^ . _:b446364237 . _:b446363320 . _:b446361941 "3"^^ . _:b446361940 "3"^^ . _:b446361943 "3"^^ . _:b446361620 . _:b446363399 . _:b446361942 "3"^^ . _:b446361937 "3"^^ . _:b446361321 . _:b446361936 "3"^^ . _:b446362188 . . _:b446361939 "3"^^ . . . _:b446361938 "3"^^ . . _:b446361770 . _:b446361949 "3"^^ . _:b446361948 "3"^^ . _:b446361951 "3"^^ . . _:b446361950 "3"^^ . . _:b446361945 "3"^^ . _:b446364323 . _:b446361944 "3"^^ . . _:b446362810 . _:b446362698 . _:b446361947 "3"^^ . . _:b446363432 . _:b446361946 "3"^^ . . . _:b446361957 "3"^^ . . _:b446363696 . _:b446362917 . _:b446361956 "3"^^ . . _:b446361959 "3"^^ . . _:b446361958 "3"^^ . _:b446363939 . . _:b446361953 "3"^^ . _:b446363612 . _:b446363743 . _:b446364632 . _:b446361957 . _:b446361952 "3"^^ . . _:b446361955 "3"^^ . . _:b446360857 . _:b446361371 . _:b446361954 "3"^^ . . . _:b446361965 "3"^^ . _:b446362526 . . . _:b446361964 "3"^^ . _:b446364121 . . _:b446361967 "3"^^ . _:b446361966 "3"^^ . . _:b446361961 "3"^^ . _:b446361960 "3"^^ . . . . _:b446361963 "3"^^ . _:b446362928 . _:b446364468 . _:b446361962 "3"^^ . _:b446362784 . . _:b446361973 "3"^^ . _:b446362627 . _:b446363455 . _:b446361972 "3"^^ . . _:b446362429 . _:b446361205 . . _:b446361975 "3"^^ . . _:b446363485 . . _:b446361974 "3"^^ . . . _:b446364571 . _:b446362715 . . _:b446361969 "3"^^ . _:b446362351 . _:b446363316 . _:b446361968 "3"^^ . . _:b446361971 "3"^^ . . _:b446361970 "3"^^ . _:b446364325 . _:b446361981 "3"^^ . _:b446363131 . _:b446361810 . _:b446361980 "3"^^ . _:b446363660 . _:b446361983 "3"^^ . . _:b446361982 "3"^^ . _:b446361977 "3"^^ . . _:b446361976 "3"^^ . _:b446363264 . _:b446361979 "3"^^ . . . _:b446361978 "3"^^ . . _:b446361989 "3"^^ . . _:b446361988 "3"^^ . _:b446362629 . . _:b446361991 "3"^^ . _:b446361990 "3"^^ . _:b446361985 "3"^^ . . _:b446363407 . _:b446363782 . _:b446361984 "3"^^ . . _:b446361987 "3"^^ . . _:b446363881 . _:b446361986 "3"^^ . . _:b446362980 . _:b446361997 "3"^^ . _:b446363542 . . _:b446361996 "3"^^ . . _:b446363210 . _:b446360984 . _:b446361999 "3"^^ . _:b446361998 "3"^^ . . _:b446361993 "3"^^ . _:b446361992 "3"^^ . _:b446362639 . . _:b446362094 . . . _:b446363875 . _:b446361995 "3"^^ . . _:b446361764 . _:b446361993 . _:b446361136 . _:b446361994 "3"^^ . _:b446364497 . _:b446362005 "3"^^ . . . _:b446362004 "3"^^ . _:b446363591 . _:b446364056 . . _:b446362007 "3"^^ . _:b446364076 . _:b446362006 "3"^^ . . _:b446364280 . _:b446362001 "3"^^ . _:b446364047 . . _:b446362000 "3"^^ . _:b446362878 . _:b446361406 . _:b446363417 . _:b446362003 "3"^^ . _:b446363280 . . _:b446362002 "3"^^ . . _:b446364492 . _:b446362013 "3"^^ . _:b446362012 "3"^^ . _:b446361545 . . . _:b446362015 "3"^^ . _:b446362014 "3"^^ . . _:b446363722 . _:b446361731 . _:b446362009 "3"^^ . _:b446363456 . _:b446362008 "3"^^ . _:b446361305 . _:b446361800 . _:b446362011 "3"^^ . . _:b446364159 . _:b446362010 "3"^^ . _:b446362894 . _:b446364351 . _:b446362426 . _:b446362021 "3"^^ . _:b446360854 . . _:b446362798 . . _:b446362786 . _:b446362020 "3"^^ . _:b446362023 "3"^^ . _:b446362022 "3"^^ . _:b446364372 . . _:b446362017 "3"^^ . . . _:b446362016 "3"^^ . . _:b446362019 "3"^^ . _:b446363727 . _:b446362018 "3"^^ . _:b446363165 . _:b446362029 "3"^^ . _:b446362028 "3"^^ . _:b446364184 . _:b446362031 "3"^^ . . . _:b446362030 "3"^^ . _:b446362570 . _:b446362025 "3"^^ . _:b446362024 "3"^^ . . . _:b446362232 . _:b446362027 "3"^^ . _:b446362026 "3"^^ . _:b446360962 . _:b446361763 . _:b446362037 "3"^^ . _:b446363201 . . . . . _:b446362036 "3"^^ . . _:b446362039 "3"^^ . _:b446364282 . . _:b446362038 "3"^^ . _:b446362512 . . _:b446362033 "3"^^ . . _:b446362032 "3"^^ . . _:b446362035 "3"^^ . _:b446362034 "3"^^ . _:b446364666 . _:b446364306 . _:b446362045 "3"^^ . . _:b446362044 "3"^^ . . _:b446362047 "3"^^ . _:b446361016 . _:b446362046 "3"^^ . _:b446364160 . _:b446362041 "3"^^ . _:b446362549 . . _:b446362040 "3"^^ . _:b446362391 . _:b446363148 . _:b446362043 "3"^^ . . _:b446362042 "3"^^ . _:b446364150 . _:b446362053 "3"^^ . _:b446363532 . _:b446362052 "3"^^ . _:b446362055 "3"^^ . _:b446362054 "3"^^ . _:b446362327 . _:b446362374 . _:b446362049 "3"^^ . _:b446364145 . _:b446362048 "3"^^ . . _:b446362314 . . _:b446362051 "3"^^ . _:b446362050 "3"^^ . _:b446362061 "3"^^ . . _:b446362060 "3"^^ . . . _:b446361774 . _:b446362063 "3"^^ . . . _:b446362062 "3"^^ . _:b446362109 . _:b446362057 "3"^^ . _:b446362056 "3"^^ . . _:b446362059 "3"^^ . _:b446362058 "3"^^ . _:b446361970 . _:b446362069 "3"^^ . _:b446363105 . _:b446362925 . _:b446362068 "3"^^ . _:b446362071 "3"^^ . _:b446362070 "3"^^ . _:b446360953 . _:b446362065 "3"^^ . . _:b446362064 "3"^^ . _:b446361754 . . _:b446362067 "3"^^ . _:b446360957 . _:b446362238 . _:b446363889 . _:b446362066 "3"^^ . _:b446362754 . _:b446362077 "3"^^ . _:b446362076 "3"^^ . . _:b446362325 . _:b446362079 "3"^^ . _:b446363607 . . . _:b446360871 . . _:b446362078 "3"^^ . _:b446363946 . _:b446362073 "3"^^ . _:b446362072 "3"^^ . _:b446361039 . _:b446362075 "3"^^ . _:b446362074 "3"^^ . _:b446364646 . _:b446362085 "3"^^ . _:b446361860 . _:b446362371 . _:b446362084 "3"^^ . . _:b446362087 "3"^^ . _:b446363577 . _:b446362086 "3"^^ . . _:b446362081 "3"^^ . _:b446363441 . _:b446363841 . _:b446362080 "3"^^ . _:b446363270 . _:b446362884 . _:b446361037 . _:b446362640 . _:b446362083 "3"^^ . _:b446362082 "3"^^ . _:b446362093 "3"^^ . _:b446364417 . _:b446362092 "3"^^ . _:b446362631 . _:b446362095 "3"^^ . _:b9113978 "Xenograft enriched or low passage cell lines were generated from the post mortem cancer tissues of these seven patients as previously described 13,>>14<<." . _:b446361266 . . . _:b446362094 "3"^^ . . . _:b446362089 "3"^^ . _:b446362088 "3"^^ . . . . _:b446362607 . _:b446362091 "3"^^ . . _:b446362090 "3"^^ . _:b446364347 . _:b446363025 . _:b446363429 . _:b446362101 "3"^^ . . _:b446362100 "3"^^ . _:b446362258 . _:b446362279 . _:b446364414 . . . _:b446361216 . . _:b446362103 "3"^^ . _:b446362102 "3"^^ . _:b446362330 . . _:b446364083 . _:b446362097 "3"^^ . _:b446362912 . _:b446364034 . _:b446362096 "3"^^ . _:b446363640 . _:b446363522 . . . _:b446362099 "3"^^ . . _:b446362098 "3"^^ . . _:b446362109 "3"^^ . _:b446360995 . _:b446361850 . _:b446362108 "3"^^ . _:b446363753 . _:b446364452 . _:b446362111 "3"^^ . _:b446363978 . . . _:b446362110 "3"^^ . _:b446362096 . _:b446362105 "3"^^ . _:b446363926 . _:b446362104 "3"^^ . _:b446362107 "3"^^ . _:b446363754 . _:b446362106 "3"^^ . . . . _:b446364308 . . . . _:b446361611 . . . _:b446364659 . . . . _:b446362592 . . _:b446363244 . . . . . . . _:b446364621 . . _:b446362311 . . _:b446364485 . . . _:b446364010 . . _:b446363861 . _:b446361907 . _:b446363007 . . _:b446363024 . _:b446362995 . _:b446363413 . _:b446364638 . . _:b446363002 . . . . . _:b446363749 . . _:b446361340 . _:b446362859 . . . . _:b446361082 . . . _:b446363128 . _:b446363031 . _:b446364062 . _:b446364445 . . . . . . . . . . . _:b446362941 . . . . _:b446363163 . _:b446361823 . . _:b446361370 . _:b446361813 . _:b446364099 . . _:b446363394 . _:b446361341 . . _:b446362560 . . . . . . _:b446364436 . . _:b446361284 . _:b446361285 . _:b446361286 . _:b446361287 . _:b446364129 . _:b446362135 . _:b446361280 . _:b446361281 . . _:b446361282 . _:b446361283 . _:b446361193 . _:b446361292 . _:b446361293 . _:b446361294 . _:b446364327 . _:b446361295 . . _:b446361288 . _:b446361289 . _:b446361290 . _:b446364212 . _:b446361291 . _:b446361300 . _:b446361301 . _:b446361302 . . _:b446361303 . _:b446362781 . _:b446361296 . _:b446361507 . _:b446361297 . _:b446364428 . _:b446361298 . _:b446361299 . . . _:b446361308 . _:b446361309 . _:b446361310 . _:b446361311 . _:b446361304 . _:b446362108 . _:b446361305 . . _:b446361306 . _:b446361307 . _:b446362035 . _:b446361316 . _:b446361317 . _:b446361318 . _:b446361319 . _:b446361312 . _:b446361313 . _:b446361314 . _:b446361562 . _:b446361315 . _:b446362489 . _:b446361324 . _:b446361325 . _:b446362410 . _:b446361326 . _:b446363371 . _:b446361327 . . . _:b446361320 . . _:b446361321 . _:b446361296 . _:b446361322 . _:b446361323 . _:b446361332 . _:b446361333 . . _:b446361334 . _:b446361335 . _:b446361328 . . _:b446361329 . 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. _:b446361107 . _:b446364207 . _:b446361116 . _:b446360910 . _:b446361117 . _:b446361118 . _:b446361119 . _:b446361112 . _:b446361113 . _:b446361114 . _:b446361115 . _:b446361124 . _:b446361125 . _:b446361126 . _:b446361127 . _:b446363416 . _:b446361120 . _:b446361121 . _:b446361122 . _:b446361123 . . _:b446361132 . _:b446361133 . . _:b446361134 . _:b446362340 . _:b446361135 . _:b446361128 . _:b446362446 . _:b446361129 . _:b446361130 . _:b446361131 . . _:b446361140 . _:b446361141 . _:b446361142 . _:b446361143 . _:b446361136 . . _:b446361137 . _:b446361138 . _:b446361139 . _:b446361148 . _:b446361149 . . _:b446361150 . _:b446361151 . _:b446361144 . _:b446361145 . _:b446361125 . . _:b446361146 . _:b446361147 . _:b446361540 . _:b446361541 . _:b446361542 . _:b446361543 . _:b446362212 . _:b446361536 . . _:b446361537 . _:b446361538 . _:b446361539 . _:b446361548 . _:b446361549 . _:b446361550 . _:b446361551 . _:b446361544 . _:b446362443 . _:b446361545 . _:b446361546 . _:b446361547 . 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. . . _:b446362341 . _:b446363574 . _:b446363569 . . _:b446363568 . _:b446362282 . _:b446362628 . _:b446363571 . _:b446363570 . _:b446363422 . _:b446363581 . _:b446363580 . . _:b446363271 . _:b446363583 . _:b446363582 . _:b446361614 . _:b446362419 . _:b446363577 . . . . _:b446363576 . . _:b446363579 . _:b446363644 . _:b446363578 . _:b446361088 . _:b446363589 . . _:b446362243 . _:b446363588 . _:b446363591 . _:b446364352 . . _:b446363590 . . . . _:b446363585 . _:b446362571 . _:b446363584 . _:b446364049 . _:b446363587 . _:b446363586 . . _:b446363539 . . _:b446363597 . _:b446360901 . . _:b446363596 . . . _:b446363933 . _:b446363599 . _:b446364354 . _:b446364518 . _:b446363176 . _:b446363598 . _:b446363364 . _:b446363593 . _:b446363592 . . _:b446363595 . . _:b446363626 . _:b446363594 . . . _:b446363410 . _:b446363605 . _:b446363012 . _:b446363604 . . . _:b446363607 . . _:b446363606 . _:b446363951 . _:b446363457 . _:b446363601 . . . _:b446362406 . _:b446363600 . _:b446363603 . . _:b446363602 . . _:b446363613 . _:b446361639 . _:b446363612 . _:b446363615 . _:b446362010 . . _:b446364253 . _:b446363614 . _:b446363769 . _:b446363609 . . . _:b446363608 . . _:b446362942 . . . _:b446364463 . _:b446363611 . . _:b446362543 . _:b446363610 . . _:b446362788 . _:b446363621 . _:b446362744 . _:b446364462 . _:b446363620 . _:b446364650 . . _:b446363623 . . . _:b446363622 . _:b446363617 . . _:b446363616 . _:b446362516 . _:b446360851 . _:b446363619 . _:b446362965 . . _:b446363618 . _:b446362112 . _:b446363629 . _:b446363628 . _:b446361434 . _:b446363631 . . _:b446363630 . _:b446363625 . _:b446363624 . _:b446363627 . _:b446361773 . _:b446361365 . . . _:b446363626 . _:b446363637 . . _:b446363153 . . _:b446362211 . _:b446363636 . _:b446362372 . _:b446363639 . _:b446362256 . _:b446363638 . _:b446361689 . _:b446363633 . _:b446361975 . _:b446363632 . _:b446363635 . . . _:b446363634 . _:b446360971 . _:b446363645 . . _:b446364489 . _:b446363644 . _:b446361591 . . _:b446363647 . . _:b446363733 . _:b446363646 . _:b446364073 . . _:b446363641 . _:b446364604 . _:b446363355 . _:b446364208 . _:b446363640 . _:b446364335 . . _:b446363643 . . _:b446361298 . _:b446363642 . . _:b446363141 . . . . _:b446363140 . . _:b446363143 . _:b446361979 . _:b446362234 . _:b446363142 . _:b446362145 . _:b446361533 . _:b446363137 . _:b446363136 . . _:b446363139 . _:b446363138 . . _:b446363149 . . _:b446361484 . _:b446363148 . _:b446362472 . _:b446363151 . _:b446360886 . _:b446363056 . _:b446363150 . . _:b446360865 . _:b446363145 . . _:b446361457 . _:b446363144 . _:b446363147 . _:b446362359 . _:b446361875 . . _:b446363146 . _:b446363465 . _:b446363157 . . . _:b446363156 . _:b446363159 . _:b446361852 . _:b446363158 . _:b446361635 . . _:b446363153 . _:b446363152 . _:b446363155 . . _:b446362288 . . _:b446363154 . . _:b446363165 . . _:b446363164 . _:b446363167 . _:b446363701 . . . _:b446363166 . . _:b446361390 . _:b446363161 . . _:b446363160 . _:b446363534 . . _:b446363163 . _:b446363490 . _:b446363162 . . . _:b446363173 . . _:b446363172 . _:b446363220 . _:b446363175 . _:b446363174 . _:b446362381 . _:b446363169 . . _:b446363168 . _:b446363171 . _:b446363420 . _:b446363170 . . . _:b446363181 . _:b446363684 . . _:b446363180 . _:b446363183 . _:b446363182 . _:b446363177 . _:b446363176 . _:b446364509 . _:b446363179 . . _:b446362479 . _:b446363178 . _:b446363189 . _:b446360869 . _:b446363188 . _:b446363266 . _:b446363191 . . _:b446363190 . _:b446364563 . _:b446363625 . _:b446362968 . _:b446363185 . _:b446364398 . _:b446363038 . _:b446363184 . _:b446363187 . _:b446364587 . _:b446361741 . _:b446363186 . _:b446363197 . . . _:b446361911 . _:b446361833 . _:b446364353 . _:b446363196 . . _:b446363199 . _:b446363198 . . _:b446361393 . _:b446363193 . _:b446363180 . . _:b446363192 . _:b446364141 . _:b446363195 . . _:b446363681 . _:b446363194 . _:b446362196 . _:b446363205 . _:b446361251 . _:b446361450 . . _:b446362546 . _:b446363204 . . _:b446361643 . _:b446361302 . _:b446363207 . _:b446364558 . . _:b446363206 . _:b446361522 . _:b446362787 . _:b446363336 . _:b446363201 . . _:b446361494 . _:b446363200 . . _:b446363203 . _:b446363409 . _:b446362972 . _:b446363202 . _:b446364345 . . _:b446364564 . _:b446363671 . _:b446363213 . . . _:b446363212 . _:b446363880 . . . _:b446363215 . _:b446363214 . . _:b446363209 . . . _:b446363208 . . . _:b446363211 . _:b446363210 . . _:b446361933 . _:b446363221 . . _:b446362495 . . _:b446363220 . _:b446363223 . _:b446363288 . _:b446363222 . _:b446361005 . _:b446363217 . _:b446361294 . _:b446361420 . _:b446363216 . _:b446363265 . . _:b446363219 . . . . _:b446362360 . _:b446363218 . . _:b446363229 . _:b446363787 . _:b446363228 . _:b446363231 . . . _:b446363230 . . _:b446363225 . . . _:b446363224 . _:b446364363 . _:b446363227 . _:b446363883 . _:b446361052 . _:b446363226 . _:b446362493 . . . _:b446363237 . . _:b446364279 . . _:b446363236 . _:b446363474 . . . _:b446363239 . _:b446361814 . _:b446363780 . _:b446363238 . _:b446363379 . _:b446363233 . _:b446361254 . _:b446361525 . . _:b446363232 . . _:b446363235 . . _:b446363803 . _:b446362092 . _:b446363234 . _:b446363245 . _:b446363244 . . . _:b446363247 . _:b446364516 . _:b446363246 . . . _:b446363241 . _:b446362063 . _:b446363184 . . . _:b446363240 . . _:b446362251 . . _:b446363243 . _:b446363330 . _:b446362753 . _:b446363242 . _:b446363253 . _:b446363122 . . _:b446363252 . . _:b446363255 . _:b446360965 . . _:b446363254 . _:b446362127 . _:b446363249 . _:b446363248 . _:b446362902 . _:b446363251 . _:b446363250 . . _:b446361788 . _:b446363261 . _:b446363260 . . _:b446363263 . _:b446363262 . . _:b446363045 . . _:b446363887 . _:b446363257 . . _:b446363256 . _:b446362463 . _:b446363259 . . _:b446361811 . _:b446363258 . _:b446361638 . _:b446363269 . _:b446362164 . _:b446364220 . . _:b446363268 . _:b446362040 . _:b446363271 . _:b446362961 . _:b446361413 . . _:b446363270 . . . . _:b446363272 . _:b446364594 . _:b446363265 . _:b446361877 . . _:b446362725 . _:b446363264 . _:b446361409 . _:b446363267 . _:b446363442 . . _:b446361079 . . _:b446363266 . _:b446363126 . . . _:b446363277 . . _:b446363276 . . _:b446363279 . _:b9113981 "Since the number of base pairs sequenced in the study is 31.7\u00B7106, and the mutation rate per base pair per generation is estimated at 5\u00B710\u221210, r = 31.7\u00B7106\u00B75\u00B710\u221210 \u2248 0.016 per generation >>8<<." . _:b446363278 . . . _:b446363273 . _:b9113982 . _:b446363272 . _:b446364235 . _:b446360862 . _:b446363275 . . _:b446363274 . . _:b446362230 . _:b446363285 . . _:b446363284 . _:b446363287 . . _:b446363286 . _:b446362452 . _:b446360970 . _:b446363281 . _:b446363280 . _:b446363283 . _:b446362767 . . _:b446360873 . _:b446363282 . _:b446362116 . . _:b446363293 . _:b446363292 . _:b446362284 . . _:b446363295 . . _:b446363294 . _:b446363289 . . _:b446362970 . _:b446363288 . . . . . _:b446363291 . _:b446362561 . _:b446363290 . _:b446363301 . . . _:b446363300 . . _:b446363303 . _:b446363302 . _:b446363737 . _:b446363297 . _:b446362034 . _:b446363296 . . _:b446363299 . _:b446363298 . _:b446361779 . . _:b446363309 . _:b446363308 . . _:b446363311 . . _:b446363310 . _:b446363597 . _:b446363305 . _:b446363075 . _:b446363304 . _:b446363307 . _:b446363306 . _:b446363317 . _:b446363316 . _:b446363319 . _:b446360872 . _:b446363318 . _:b446363313 . _:b446361878 . _:b446363312 . _:b446361536 . _:b446363315 . . _:b446363314 . _:b446363325 . . _:b446363324 . _:b446362029 . _:b446363327 . . _:b446363326 . . _:b446363774 . _:b446363321 . _:b446362748 . _:b446363320 . _:b446363323 . _:b446363322 . _:b446360992 . _:b446362163 . _:b446363333 . . _:b446361659 . . _:b446363332 . _:b446362612 . _:b446363335 . . _:b446364116 . . _:b446363334 . . _:b446363329 . _:b446361022 . _:b446363328 . . . . _:b446363378 . _:b446363331 . . _:b446363330 . _:b446361817 . _:b446361091 . _:b446363341 . _:b446363340 . _:b446363812 . . _:b446363343 . . _:b446363342 . . _:b446363337 . . _:b446363336 . . . . _:b446363339 . _:b446363800 . . _:b446363042 . _:b446362209 . _:b446363084 . _:b446363338 . . . _:b446363349 . . . . _:b446363348 . . _:b446364668 . _:b446363351 . . . _:b446363350 . . _:b446364508 . _:b446361126 . _:b446363345 . _:b446363344 . _:b446363213 . _:b446364042 . . _:b446363347 . _:b446363346 . _:b446363357 . _:b446361798 . _:b446363356 . _:b446363359 . . _:b446363358 . . _:b446363353 . . _:b446363352 . _:b446363676 . _:b446361472 . _:b446363253 . _:b446363355 . _:b446363354 . . _:b446364649 . _:b446363365 . . _:b446363364 . . _:b446363367 . _:b446361478 . _:b446363366 . _:b446363361 . _:b446362320 . . _:b446363360 . _:b446363363 . _:b446362246 . _:b446363257 . _:b446362157 . _:b446363140 . _:b446363362 . _:b446363373 . _:b446362023 . . _:b446363372 . . . _:b446363375 . . _:b446361360 . _:b446363968 . . _:b446363374 . _:b446363731 . . _:b446362548 . _:b446363899 . . _:b446363369 . . . _:b446363368 . _:b446363371 . _:b446364665 . _:b446364025 . . . _:b446363370 . _:b446363381 . _:b446361312 . _:b446361900 . _:b446363380 . . . . _:b446363383 . . _:b446363382 . . _:b446363377 . _:b446363167 . _:b446363376 . _:b446363379 . _:b446361749 . _:b446363378 . _:b446362959 . _:b446363389 . . . _:b446362008 . . _:b446363388 . _:b446364565 . . _:b446363391 . _:b446363390 . . _:b446363622 . . _:b446363385 . . . _:b446362978 . _:b446363384 . _:b446364037 . _:b446363387 . _:b446363386 . . . _:b446361049 . _:b446362885 . . _:b446362884 . . _:b446362887 . _:b446363357 . . . _:b446362886 . . _:b446362881 . _:b446362459 . _:b446362880 . _:b446363828 . . _:b446361258 . _:b446362883 . . _:b446362882 . . . _:b446362893 . . _:b446362892 . . _:b446362895 . . _:b446362894 . _:b446362889 . . _:b446362888 . _:b446364181 . . . _:b446362891 . _:b446362890 . _:b446360863 . _:b446361387 . _:b446362901 . _:b446362318 . . _:b446362900 . _:b446362685 . . _:b446364423 . _:b446362903 . _:b446362987 . . _:b446362902 . . _:b446362897 . . _:b446362896 . _:b446362899 . _:b446362898 . . _:b446362909 . _:b446363089 . _:b446361996 . _:b446362908 . _:b446362911 . _:b446361816 . _:b446361465 . _:b446362910 . _:b446364075 . . _:b446362905 . _:b446364134 . _:b446362904 . _:b446362907 . _:b446363650 . _:b446362906 . _:b446364117 . _:b446362917 . _:b446362233 . . _:b446362916 . . _:b446362919 . . _:b446362918 . _:b9113979 "For each SNP, the normalized allele intensity ratio (theta) was used to estimate a quantitative allelic frequency value (called the \u201CB Allele Frequency\u201D) for that SNP >>15<<. Using Illumina BeadStudio software, LogR Ratio and B Allele Frequency values were plotted along chromosomal coordinates and examined visually. Regions of loss of heterozygosity (LOH) were identified as genomic regions >2Mb with" . . _:b446364656 . _:b446363531 . _:b446362913 . . . _:b446362912 . _:b446363554 . _:b446361791 . . _:b446362915 . _:b446362136 . _:b446364251 . _:b446362914 . _:b446363338 . _:b446361699 . _:b446362925 . . _:b446362924 . _:b446363566 . _:b446362927 . _:b446361274 . _:b446362464 . _:b446362926 . . . _:b446362921 . _:b446362920 . _:b446361282 . _:b446361826 . _:b446361674 . _:b446362923 . _:b446362922 . . _:b446362933 . _:b446362932 . _:b446362935 . _:b446362934 . _:b446362929 . _:b446362928 . _:b446362931 . _:b446364171 . _:b446362930 . _:b446362941 . _:b446360875 . _:b446362940 . . _:b446362830 . _:b446364382 . _:b446363324 . _:b446362943 . . _:b446362942 . . _:b446362937 . _:b446362936 . _:b446362146 . _:b446362939 . _:b446364204 . _:b446362938 . _:b446361481 . _:b446362949 . _:b446362948 . _:b446363027 . _:b446363710 . _:b446362951 . . _:b446362950 . _:b446361987 . . _:b446362945 . _:b446362944 . _:b446362947 . _:b446363594 . _:b446362946 . _:b446363628 . _:b446362957 . . . _:b446362956 . _:b446362959 . _:b446362958 . . _:b446363820 . _:b446362953 . . _:b446363349 . . _:b446362952 . . _:b446362955 . _:b446362026 . _:b446363893 . _:b446362038 . _:b446362954 . . . _:b446362965 . . . _:b446362644 . _:b446362964 . . . _:b446362967 . _:b446362966 . _:b446363234 . . _:b446362961 . _:b446363467 . . . . . . _:b446362960 . _:b446361601 . _:b446362963 . _:b446360889 . _:b446362962 . _:b446363816 . _:b446360856 . . _:b446362973 . _:b446362972 . _:b446361154 . . . . _:b446362975 . . _:b446362384 . _:b446362974 . _:b446361405 . _:b446362969 . . _:b446364589 . _:b446362013 . _:b9113985 "Amikura et al >>20<< also reported the median doubling time of pancreatic cancer metastases as 56 days." . _:b446362968 . _:b446362971 . _:b446363498 . _:b446362970 . _:b446362981 . _:b446364033 . _:b446364394 . _:b446362980 . _:b446361586 . . _:b446362983 . _:b446362982 . . _:b446362977 . . _:b446362976 . _:b446362979 . . _:b446362978 . . _:b446360943 . _:b446362989 . . _:b446362988 . . _:b446361204 . _:b446362991 . _:b446362223 . _:b446362343 . _:b446362990 . _:b446362985 . . _:b446362984 . . _:b446363448 . _:b446362987 . _:b446362986 . . . _:b446362622 . _:b446362997 . _:b446362996 . . _:b446362999 . _:b446363706 . _:b446362998 . _:b446361684 . _:b446362274 . . . . _:b446362993 . _:b446362528 . _:b446362992 . . _:b446363813 . _:b446362995 . _:b446362994 . _:b446363005 . _:b446363157 . . _:b446363004 . . _:b446363007 . _:b446361491 . _:b446363006 . . _:b446362782 . _:b446363001 . _:b446364644 . . . . _:b446364426 . _:b446364179 . . _:b446363000 . _:b446362336 . . . _:b446363003 . _:b446361421 . . _:b446363002 . _:b9113978 . _:b446363013 . . _:b446363012 . _:b446364209 . . _:b446362430 . _:b446362881 . _:b446363015 . . _:b446363014 . . _:b446363009 . _:b446362808 . _:b446362397 . _:b446363008 . _:b446364647 . . _:b446363011 . _:b446363230 . _:b446363010 . _:b446361642 . _:b446363021 . _:b446363020 . _:b446363023 . _:b446361235 . _:b446363022 . _:b446362670 . _:b446363017 . . . _:b446363016 . _:b446363019 . _:b446363018 . _:b446364533 . _:b446364538 . _:b446362323 . _:b446363029 . _:b446363028 . _:b446360880 . _:b446363031 . _:b446363996 . _:b446363030 . . _:b446363611 . _:b446363025 . _:b446363024 . . _:b446361200 . _:b446363027 . _:b446363026 . _:b446362783 . _:b446363037 . _:b446363036 . _:b446363039 . _:b446362119 . _:b446363038 . _:b446363033 . _:b446363647 . _:b446363032 . _:b446361085 . _:b446363035 . . . _:b446363034 . . . _:b446363045 . _:b446363044 . . _:b446361516 . . . _:b446363047 . . . _:b446363046 . _:b446363041 . _:b446364089 . _:b446363040 . . . . _:b446363043 . . _:b446363042 . . _:b446361353 . _:b446363053 . . _:b446363052 . . . _:b446363055 . _:b446363054 . _:b446363049 . _:b446363755 . _:b446363048 . . _:b446363695 . _:b446361615 . _:b446364128 . _:b446363051 . _:b446363691 . _:b446363050 . . . _:b446363061 . . _:b446363959 . _:b446364165 "2"^^ . _:b446363060 . . _:b446361170 . _:b446364164 "2"^^ . _:b446363063 . _:b446361128 . _:b446364167 "2"^^ . _:b446363601 . _:b446363062 . . _:b446364166 "2"^^ . _:b446362506 . _:b446363884 . _:b446363057 . _:b446362447 . _:b446364161 "2"^^ . _:b446363056 . _:b446364160 "2"^^ . _:b446363059 . . _:b446364163 "2"^^ . . _:b446363058 . . _:b446362184 . _:b446364162 "2"^^ . . . _:b446363069 . . . _:b446364173 "2"^^ . . . _:b446363068 . . . _:b446364172 "2"^^ . _:b446363071 . _:b446360919 . _:b446364175 "2"^^ . _:b446363070 . _:b446364174 "2"^^ . _:b446363065 . _:b446363454 . _:b446364169 "2"^^ . _:b446363064 . . _:b446363306 . _:b446361729 . _:b446364168 "2"^^ . _:b446363067 . . _:b446364171 "2"^^ . _:b446363066 . _:b446364170 "2"^^ . _:b446363077 . . _:b446364181 "2"^^ . . _:b446363076 . . _:b446364026 . . _:b446364432 . _:b446364180 "2"^^ . _:b446363079 . . _:b446364424 . . _:b446364183 "2"^^ . . _:b446363078 . _:b446364095 . _:b446364182 "2"^^ . _:b446363073 . _:b446364177 "2"^^ . _:b446363072 . _:b446364054 . _:b446364176 "2"^^ . _:b446363075 . _:b446364179 "2"^^ . _:b446363074 . . _:b446364178 "2"^^ . . _:b446363085 . _:b446362918 . _:b446364278 . _:b446364189 "2"^^ . _:b446363084 . . _:b446364188 "2"^^ . _:b446363087 . . _:b446362317 . _:b446364191 "2"^^ . _:b446363086 . _:b446364190 "2"^^ . _:b446363081 . _:b446361366 . _:b446363981 . _:b446364185 "2"^^ . _:b446363080 . _:b446364184 "2"^^ . _:b446363083 . . . _:b446364187 "2"^^ . _:b446361002 . _:b446363082 . . _:b446363477 . _:b446364186 "2"^^ . _:b446363093 . _:b446364197 "2"^^ . _:b446363092 . . _:b446363544 . _:b446364196 "2"^^ . . _:b446363227 . _:b446363095 . . _:b446364379 . _:b446364365 . . _:b446364199 "2"^^ . _:b446363094 . . _:b446364198 "2"^^ . _:b446363089 . _:b446364193 "2"^^ . _:b446363088 . _:b446364192 "2"^^ . _:b446363091 . _:b446364195 "2"^^ . _:b446363090 . _:b446364194 "2"^^ . _:b446363101 . _:b446361310 . . _:b446364205 "2"^^ . _:b446363100 . _:b446364204 "2"^^ . . _:b446363103 . . _:b446364207 "2"^^ . _:b446363102 . _:b446364052 . _:b446364206 "2"^^ . . _:b446363097 . . _:b446364201 "2"^^ . _:b446363096 . . _:b446364200 "2"^^ . _:b446363099 . _:b446364465 . _:b446364634 . _:b446364203 "2"^^ . _:b446363098 . _:b446364202 "2"^^ . . _:b446363109 . _:b446363545 . _:b446364213 "2"^^ . . _:b446363108 . _:b446364212 "2"^^ . . _:b446363111 . _:b446361271 . . . _:b446364215 "2"^^ . _:b446363110 . . _:b446364214 "2"^^ . _:b446363105 . . . _:b446363019 . _:b446362609 . _:b446364209 "2"^^ . _:b446363104 . . _:b446364208 "2"^^ . _:b446361138 . _:b446363107 . . _:b446364211 "2"^^ . . _:b446363106 . . _:b446364210 "2"^^ . _:b446363117 . . _:b446364221 "2"^^ . _:b446363116 . . . _:b446364220 "2"^^ . _:b446363119 . _:b446364223 "2"^^ . _:b446363118 . . _:b446364222 "2"^^ . _:b446363113 . _:b446364217 "2"^^ . . _:b446363112 . . _:b446361576 . _:b446364295 . _:b446364216 "2"^^ . _:b446363115 . _:b446363756 . _:b446364219 "2"^^ . _:b446363114 . _:b446364218 "2"^^ . _:b446363125 . _:b446364229 "2"^^ . _:b446364302 . . _:b446363124 . _:b446362457 . . _:b446364228 "2"^^ . _:b446362653 . _:b446363127 . _:b446364231 "2"^^ . _:b446363126 . _:b446364548 . _:b446364230 "2"^^ . . _:b446363121 . _:b446364225 "2"^^ . _:b446362909 . _:b446363120 . _:b446364224 "2"^^ . _:b446363123 . _:b446361895 . _:b446364227 "2"^^ . _:b446363122 . . _:b446364226 "2"^^ . _:b446363133 . _:b446364186 . _:b446364237 "2"^^ . _:b446363132 . . . _:b446364236 "2"^^ . _:b446363135 . _:b446361249 . . _:b446364239 "2"^^ . _:b446362544 . _:b446361479 . _:b446361077 . _:b446363134 . _:b446364238 "2"^^ . _:b446361794 . _:b446363129 . . _:b446364233 "2"^^ . _:b446363128 . _:b446363975 . _:b446364232 "2"^^ . . _:b446363131 . . _:b446362841 . _:b446361209 . _:b446364235 "2"^^ . _:b446363130 . _:b446364234 "2"^^ . _:b446362298 . _:b446362629 . . . _:b446364245 "2"^^ . _:b446362628 . _:b446361412 . . _:b446364244 "2"^^ . _:b446362631 . . _:b446364534 . _:b446364247 "2"^^ . . _:b446362630 . . . _:b446364246 "2"^^ . _:b446362625 . _:b446364241 "2"^^ . . _:b446362624 . _:b446360925 . . _:b446364240 "2"^^ . _:b446362627 . _:b446361733 . _:b446363505 . . . _:b446363219 . _:b446364243 "2"^^ . . _:b446362626 . _:b446364242 "2"^^ . _:b446362637 . _:b446361437 . _:b446364253 "2"^^ . . _:b446362636 . . _:b446364252 "2"^^ . _:b446362639 . _:b446362728 . . _:b446364255 "2"^^ . _:b446362638 . _:b446364254 "2"^^ . . _:b446362633 . _:b446364249 "2"^^ . _:b446362632 . . _:b446364248 "2"^^ . _:b446362635 . _:b446360938 . _:b446364251 "2"^^ . . _:b446362634 . . . . _:b446364016 . . _:b446364250 "2"^^ . _:b446362645 . _:b446364261 "2"^^ . _:b446362635 . _:b446362644 . . _:b446364260 "2"^^ . _:b446362647 . _:b446364263 "2"^^ . _:b446362646 . _:b446362586 . _:b446361346 . _:b446364262 "2"^^ . . _:b446362641 . _:b446364144 . . _:b446364257 "2"^^ . . _:b446362640 . _:b446364397 . . . _:b446364256 "2"^^ . _:b446362643 . _:b446362718 . . _:b446364259 "2"^^ . _:b446361884 . _:b446362642 . _:b446364258 "2"^^ . _:b446362653 . . _:b446364269 "2"^^ . _:b446362652 . _:b446363621 . _:b446363860 . _:b446364268 "2"^^ . _:b446362655 . _:b446363247 . _:b446364271 "2"^^ . _:b446362654 . _:b446363415 . _:b446364270 "2"^^ . _:b446362649 . . . _:b446364265 "2"^^ . _:b446362648 . _:b446364112 . _:b446364264 "2"^^ . _:b446362377 . _:b446362651 . _:b446364267 "2"^^ . _:b446362650 . _:b446362059 . _:b446363078 . _:b446361094 "8"^^ . _:b446364266 "2"^^ . _:b446362661 . _:b446361095 "8"^^ . . _:b446364277 "2"^^ . _:b446363118 . . _:b446362660 . _:b446361092 "8"^^ . _:b446364276 "2"^^ . _:b446362663 . . _:b446363092 . _:b446361093 "8"^^ . _:b446364279 "2"^^ . _:b446362662 . . . _:b446364057 . . . _:b446361090 "8"^^ . _:b446364278 "2"^^ . _:b446364311 . _:b446362657 . . . _:b446361091 "8"^^ . _:b446362241 . _:b446364273 "2"^^ . _:b446362656 . _:b446362729 . _:b446361088 "8"^^ . . . _:b446364272 "2"^^ . . _:b446362659 . _:b446361089 "8"^^ . _:b446364275 "2"^^ . . _:b446364653 . _:b446362658 . _:b446361102 "8"^^ . _:b446364286 . _:b446364274 "2"^^ . _:b446362669 . _:b446364094 . _:b446361103 "8"^^ . _:b446364285 "2"^^ . . _:b446362922 . _:b446362668 . _:b446361100 "8"^^ . . . _:b446364284 "2"^^ . _:b446362671 . _:b446361101 "8"^^ . _:b446361627 . _:b446364287 "2"^^ . _:b446362670 . _:b446361098 "8"^^ . . _:b446364286 "2"^^ . _:b446362665 . _:b446361099 "8"^^ . _:b446364281 "2"^^ . _:b446362664 . . _:b446361096 "8"^^ . _:b446364280 "2"^^ . _:b446362667 . _:b446361097 "8"^^ . _:b446364283 "2"^^ . _:b446361463 . _:b446362666 . _:b446364547 . _:b446361110 "8"^^ . _:b446361103 . _:b446364282 "2"^^ . _:b446362677 . _:b446361111 "8"^^ . . _:b446364293 "2"^^ . . _:b446362676 . _:b446361108 "8"^^ . _:b446362795 . _:b446364292 "2"^^ . _:b446364305 . _:b446362312 . _:b446362679 . _:b446361109 "8"^^ . _:b446364295 "2"^^ . . _:b446362678 . . _:b446361106 "8"^^ . _:b446364294 "2"^^ . _:b446364617 . _:b446362673 . _:b446364520 . _:b446361107 "8"^^ . _:b446362661 . _:b446364289 "2"^^ . _:b446362672 . _:b446361104 "8"^^ . _:b446364288 "2"^^ . _:b446360895 . _:b446362675 . _:b446361654 . _:b446361105 "8"^^ . . _:b446364291 "2"^^ . _:b446362674 . _:b446361118 "8"^^ . _:b446363986 . _:b446364290 "2"^^ . _:b446362685 . _:b446361119 "8"^^ . _:b446361784 . _:b446364301 "2"^^ . . _:b446362684 . _:b446361116 "8"^^ . _:b446362118 . _:b446364300 "2"^^ . _:b446362687 . _:b446362366 . _:b446362624 . _:b446361117 "8"^^ . _:b446363269 . _:b446361832 . _:b446364303 "2"^^ . _:b446362686 . _:b446361114 "8"^^ . _:b446364302 "2"^^ . _:b446362681 . _:b446361115 "8"^^ . _:b446364297 "2"^^ . _:b446362680 . _:b446361112 "8"^^ . _:b446360935 . _:b446363395 . _:b446364296 "2"^^ . . _:b446362683 . _:b446361936 . . _:b446361113 "8"^^ . _:b446364299 "2"^^ . _:b446364572 . _:b446362682 . _:b446361126 "8"^^ . _:b446364298 "2"^^ . _:b446362693 . _:b446361127 "8"^^ . _:b446364309 "2"^^ . . _:b446362692 . _:b446361124 "8"^^ . _:b446364308 "2"^^ . . _:b446362695 . _:b446362151 . _:b446361125 "8"^^ . _:b446364311 "2"^^ . _:b446362694 . _:b446361122 "8"^^ . _:b446364310 "2"^^ . _:b446362689 . _:b446364609 . _:b446361123 "8"^^ . _:b446364305 "2"^^ . _:b446362688 . . _:b446361120 "8"^^ . _:b446364441 . _:b446364304 "2"^^ . _:b446362691 . . _:b446361121 "8"^^ . . _:b446364307 "2"^^ . _:b446362690 . _:b446361134 "7"^^ . _:b446364306 "2"^^ . _:b446362701 . _:b446361135 "7"^^ . _:b446362287 . _:b446364317 "2"^^ . _:b446362700 . . _:b446361132 "7"^^ . _:b446364316 "2"^^ . _:b446362703 . _:b446361133 "7"^^ . _:b446364301 . _:b446364319 "2"^^ . _:b446362702 . _:b446364562 . . . . _:b446361130 "8"^^ . . _:b446364318 "2"^^ . . _:b446362697 . . _:b446361131 "8"^^ . _:b446364313 "2"^^ . _:b446361971 . _:b446362696 . _:b446361128 "8"^^ . _:b446364230 . . _:b446364312 "2"^^ . _:b446362699 . _:b446361881 . _:b446363411 . _:b446361129 "8"^^ . _:b446363242 . _:b446364315 "2"^^ . . _:b446362698 . . . _:b446361142 "7"^^ . . _:b446364314 "2"^^ . _:b446362709 . _:b446361143 "7"^^ . _:b446364325 "2"^^ . _:b446362708 . _:b446361140 "7"^^ . _:b446362778 . . _:b446364324 "2"^^ . _:b446362711 . _:b446361141 "7"^^ . _:b446364327 "2"^^ . _:b446362710 . _:b446361357 . _:b446362400 . _:b446361138 "7"^^ . _:b446364326 "2"^^ . _:b446362705 . _:b446361139 "7"^^ . _:b446364321 "2"^^ . _:b446362704 . _:b446361136 "7"^^ . . _:b446361189 . _:b446364320 "2"^^ . _:b446362707 . _:b446361137 "7"^^ . _:b446363840 . _:b446360876 . _:b446364323 "2"^^ . _:b446362706 . _:b446361150 "7"^^ . . _:b446364322 "2"^^ . . . _:b446362717 . _:b446361151 "7"^^ . _:b446364333 "2"^^ . _:b446362716 . _:b446361148 "7"^^ . . _:b446361570 . _:b446364332 "2"^^ . _:b446363869 . _:b446362719 . _:b446361746 . _:b446361149 "7"^^ . _:b446364335 "2"^^ . _:b446362718 . _:b446363515 . _:b446361146 "7"^^ . . _:b446364334 "2"^^ . _:b446362713 . _:b446361147 "7"^^ . _:b446362722 . . _:b446364329 "2"^^ . _:b446362712 . _:b446361144 "7"^^ . _:b446363101 . _:b446364328 "2"^^ . _:b446362715 . _:b446361145 "7"^^ . . _:b446364331 "2"^^ . _:b446362714 . _:b446361158 "7"^^ . . . _:b446364330 "2"^^ . _:b446361566 . _:b446362725 . _:b446361159 "7"^^ . _:b446360980 . . . _:b446364341 "2"^^ . _:b446363139 . _:b446362724 . _:b446361156 "7"^^ . . . _:b446364340 "2"^^ . _:b446362727 . _:b446361157 "7"^^ . . _:b446364343 "2"^^ . . _:b446362726 . _:b446361154 "7"^^ . _:b446364342 "2"^^ . . _:b446362721 . _:b446361155 "7"^^ . _:b446362613 . _:b446364337 "2"^^ . _:b446362720 . _:b446361152 "7"^^ . _:b446363480 . _:b446362218 . _:b446364336 "2"^^ . _:b446363600 . _:b446362723 . . _:b446361153 "7"^^ . _:b446364339 "2"^^ . _:b446362722 . _:b446361166 "7"^^ . _:b446364338 "2"^^ . . _:b446362733 . _:b446361167 "7"^^ . _:b446362520 . . _:b446364349 "2"^^ . _:b446362732 . _:b446363572 . _:b446361164 "7"^^ . _:b446364348 "2"^^ . _:b446362735 . _:b446361165 "7"^^ . _:b446361863 . _:b446364351 "2"^^ . _:b446362734 . _:b446361162 "7"^^ . . _:b446362693 . _:b446364350 "2"^^ . _:b446362729 . _:b446361163 "7"^^ . _:b446363885 . _:b446364345 "2"^^ . _:b446361109 . _:b446362728 . _:b446361160 "7"^^ . _:b446364344 "2"^^ . _:b446362731 . . _:b446361161 "7"^^ . _:b446362590 . _:b446364347 "2"^^ . _:b446361730 . _:b446362730 . _:b446361174 "7"^^ . . _:b446364346 "2"^^ . _:b446363204 . . _:b446362741 . . _:b446361175 "7"^^ . _:b446361495 . _:b446364215 . . _:b446364357 "2"^^ . _:b446362740 . _:b446361172 "7"^^ . . _:b446364202 . _:b446364356 "2"^^ . _:b446362743 . . _:b446361173 "7"^^ . . _:b446364359 "2"^^ . _:b446361634 . _:b446362742 . _:b446361170 "7"^^ . . _:b446364358 "2"^^ . _:b446362737 . _:b446361171 "7"^^ . _:b446364353 "2"^^ . _:b446362736 . _:b446361967 . _:b446361168 "7"^^ . _:b446362254 . _:b446361010 . _:b446364352 "2"^^ . _:b446362739 . _:b446361169 "7"^^ . . . _:b446364355 "2"^^ . . _:b446362738 . _:b446361182 "7"^^ . . _:b446364354 "2"^^ . . _:b446362749 . _:b446361183 "7"^^ . . _:b446364365 "2"^^ . _:b446362748 . _:b446361180 "7"^^ . . . . _:b446364364 "2"^^ . _:b446362751 . _:b446361181 "7"^^ . _:b446364367 "2"^^ . _:b446362750 . _:b446361178 "7"^^ . . _:b446364366 "2"^^ . _:b446362745 . _:b446361179 "7"^^ . . _:b446364361 "2"^^ . _:b446362744 . _:b446361176 "7"^^ . . _:b446363372 . _:b446364360 "2"^^ . _:b446362747 . . _:b446363062 . . _:b446361177 "7"^^ . _:b446364363 "2"^^ . _:b446362746 . _:b446361190 "7"^^ . . _:b446364362 "2"^^ . _:b446362757 . _:b446361191 "7"^^ . . _:b446364373 "2"^^ . _:b446362756 . _:b446361188 "7"^^ . _:b446363175 . . _:b446364372 "2"^^ . . _:b446362759 . _:b446361189 "7"^^ . . _:b446364375 "2"^^ . _:b446362758 . _:b446361186 "7"^^ . _:b446364374 "2"^^ . _:b446362753 . _:b446361187 "7"^^ . _:b446364040 . _:b446364369 "2"^^ . _:b446361069 . _:b446362752 . . _:b446362192 . _:b446361184 "7"^^ . . . _:b446364368 "2"^^ . _:b446362755 . _:b446361185 "7"^^ . _:b9113982 "Using our measurements of Ki-67 labeling index of the 7 index lesions (average 16.3%), we were able to estimate the S-phase fraction of cells in the 7 index lesions (average LI=9.5%) >>17<<. Assuming a median value for the S-phase duration in human tissues and tumors, Ts, of 10 hours 18, and using the formula for the potential cell doubling time Tpot=\u03BBTs/LI, we get an estimate for Tpot of 3.5 days." . _:b446364371 "2"^^ . _:b446362754 . _:b446361198 "7"^^ . _:b446364370 "2"^^ . . _:b446362765 . _:b446361199 "7"^^ . . _:b446364381 "2"^^ . _:b446362764 . _:b446361196 "7"^^ . _:b446364380 "2"^^ . . _:b446362767 . _:b446361197 "7"^^ . _:b446361024 . _:b446364115 . _:b446364383 "2"^^ . _:b446362766 . _:b446361194 "7"^^ . _:b446362018 . _:b446364382 "2"^^ . _:b446362761 . _:b446361195 "7"^^ . _:b446364377 "2"^^ . _:b446362760 . _:b446361192 "7"^^ . _:b446363916 . _:b446364376 "2"^^ . _:b446362763 . _:b446361425 . _:b446361193 "7"^^ . _:b446364379 "2"^^ . _:b446362762 . _:b446361206 "7"^^ . _:b446362831 . _:b446362950 . _:b446364378 "2"^^ . _:b446362773 . . _:b446361207 "7"^^ . _:b446364389 "2"^^ . . _:b446362772 . . _:b446361204 "7"^^ . _:b446361349 . _:b446364388 "2"^^ . . _:b446362775 . _:b446361205 "7"^^ . _:b446361348 . _:b446364391 "2"^^ . _:b446362774 . _:b446361202 "7"^^ . _:b446361351 . _:b446364390 "2"^^ . _:b446362769 . _:b9113988 "T3 is determined from literature-based estimates of the tumor and cell doubling times, and the size of the index lesions at autopsy >>20<<." . _:b446361430 . _:b446361203 "7"^^ . _:b446361350 . _:b446364385 "2"^^ . _:b446362768 . _:b446361200 "7"^^ . _:b446361345 . _:b446364384 "2"^^ . . _:b446362771 . . _:b446361201 "7"^^ . _:b446361344 . _:b446364387 "2"^^ . _:b446361214 "6"^^ . _:b446362770 . . _:b446361347 . _:b446364471 . _:b446364386 "2"^^ . _:b446361215 "6"^^ . _:b446362781 . _:b446361346 . _:b446364397 "2"^^ . _:b446362780 . _:b446361212 "7"^^ . _:b446361357 . _:b446364396 "2"^^ . _:b446361213 "6"^^ . _:b446362783 . . _:b446361356 . _:b446364399 "2"^^ . . _:b446362782 . _:b446361210 "7"^^ . _:b446361359 . _:b446364398 "2"^^ . _:b446364320 . . _:b446362777 . _:b446361211 "7"^^ . _:b446361358 . _:b446364393 "2"^^ . _:b446362776 . _:b446361208 "7"^^ . _:b446361353 . _:b446364392 "2"^^ . _:b446362779 . _:b446361209 "7"^^ . . _:b446361352 . _:b446364395 "2"^^ . . _:b446362778 . _:b446361222 "6"^^ . _:b446361242 . _:b446363039 . _:b446361355 . _:b446364394 "2"^^ . _:b446362618 . _:b446361223 "6"^^ . _:b446362789 . . _:b446362779 . _:b446361354 . _:b446364405 "2"^^ . . _:b446362788 . . _:b446361220 "6"^^ . _:b446361365 . _:b446364404 "2"^^ . . _:b446362791 . _:b446361221 "6"^^ . _:b446361364 . _:b446364407 "2"^^ . _:b446363325 . . . _:b446362790 . _:b446361218 "6"^^ . . _:b446361367 . _:b446364406 "2"^^ . . _:b446362785 . _:b446361219 "6"^^ . _:b446361366 . _:b446364401 "2"^^ . _:b446361216 "6"^^ . _:b446363580 . _:b446362784 . _:b446361361 . _:b446364400 "2"^^ . _:b446361217 "6"^^ . _:b446364020 . _:b446362787 . . _:b446364068 . _:b446361360 . _:b446364403 "2"^^ . . _:b446361230 "6"^^ . _:b446362786 . . _:b446361363 . _:b446364402 "2"^^ . _:b446361231 "6"^^ . _:b446363063 . _:b446362797 . . _:b446361362 . _:b446364413 "2"^^ . _:b446361228 "6"^^ . _:b446362964 . _:b446362796 . . _:b446361373 . _:b446364412 "2"^^ . _:b446361229 "6"^^ . _:b446362799 . . . _:b446361372 . _:b446364415 "2"^^ . _:b446363274 . _:b446361226 "6"^^ . _:b446362798 . _:b446362617 . _:b446361375 . _:b446364414 "2"^^ . _:b446361227 "6"^^ . _:b446362793 . _:b446361374 . _:b446364409 "2"^^ . _:b446361603 . _:b446361224 "6"^^ . _:b446362792 . _:b446363079 . _:b446361369 . _:b446364408 "2"^^ . _:b446361225 "6"^^ . _:b446362795 . . . _:b446361368 . _:b446364411 "2"^^ . _:b446361984 . _:b446362794 . . _:b446361238 "6"^^ . _:b446361371 . _:b446364410 "2"^^ . _:b446361239 "6"^^ . _:b446362805 . _:b446361370 . _:b446364421 "2"^^ . _:b446363704 . . _:b446361236 "6"^^ . _:b446364529 . _:b446362804 . _:b446361196 . _:b446361381 . _:b446364420 "2"^^ . . _:b446361237 "6"^^ . _:b446362807 . _:b446363248 . _:b446361380 . _:b446364423 "2"^^ . _:b446361234 "6"^^ . _:b446362806 . _:b446361383 . _:b446364422 "2"^^ . _:b446364387 . _:b446361235 "6"^^ . _:b446362801 . . _:b446361382 . _:b446364417 "2"^^ . . _:b446362800 . _:b446361232 "6"^^ . _:b446361655 . _:b446361377 . _:b446364416 "2"^^ . . _:b446362803 . _:b446361233 "6"^^ . . _:b446361376 . _:b446364419 "2"^^ . _:b446361781 . _:b446361246 "6"^^ . _:b446362802 . . . . _:b446361379 . _:b446364418 "2"^^ . _:b446361247 "6"^^ . _:b446362813 . _:b446361378 . _:b446364429 "2"^^ . _:b446361244 "6"^^ . _:b446362812 . . _:b446361969 . _:b446361389 . _:b446364428 "2"^^ . _:b446361245 "6"^^ . _:b446362815 . . . _:b446362138 . _:b446361388 . _:b446364431 "2"^^ . _:b446361242 "6"^^ . _:b446362814 . _:b446362181 . _:b446361057 . _:b446362943 . _:b446361391 . _:b446364430 "2"^^ . _:b446361243 "6"^^ . _:b446362809 . _:b446361390 . _:b446364425 "2"^^ . _:b446363717 . _:b446361240 "6"^^ . _:b446362808 . . _:b446361385 . _:b446364424 "2"^^ . _:b446361241 "6"^^ . _:b446362811 . _:b446361623 . _:b446361384 . _:b446364427 "2"^^ . _:b446361254 "6"^^ . _:b446362810 . . _:b446362473 . _:b446364168 . _:b446361387 . _:b446364426 "2"^^ . . _:b446361255 "6"^^ . _:b446362821 . _:b446361386 . _:b446364437 "2"^^ . _:b446361252 "6"^^ . _:b446362820 . _:b446361397 . _:b446364436 "2"^^ . _:b446361253 "6"^^ . _:b446362823 . . _:b446361396 . _:b446364439 "2"^^ . _:b446361250 "6"^^ . _:b446362822 . _:b446363443 . _:b446361399 . _:b446364438 "2"^^ . _:b446361251 "6"^^ . _:b446362817 . . _:b446361398 . _:b446364433 "2"^^ . . . _:b446362816 . _:b446361248 "6"^^ . _:b446361681 . _:b446361393 . _:b446364432 "2"^^ . _:b446361249 "6"^^ . _:b446362819 . _:b446363898 . _:b446361392 . _:b446364435 "2"^^ . _:b446361262 "6"^^ . _:b446362818 . _:b446361395 . _:b446364434 "2"^^ . _:b446361263 "6"^^ . _:b446362829 . _:b446362170 . _:b446364445 "2"^^ . _:b446361394 . _:b446361260 "6"^^ . _:b446362828 . _:b446361405 . _:b446364444 "2"^^ . _:b446361261 "6"^^ . _:b446362831 . _:b446362107 . _:b446361448 . _:b446361404 . _:b446364447 "2"^^ . _:b446361258 "6"^^ . _:b446362830 . _:b446361407 . _:b446364446 "2"^^ . _:b446361259 "6"^^ . _:b446362825 . _:b446361406 . _:b446364441 "2"^^ . _:b446364268 . . _:b446362824 . _:b446361256 "6"^^ . _:b446361401 . _:b446364440 "2"^^ . . _:b446362827 . . _:b446361257 "6"^^ . _:b446361400 . _:b446364443 "2"^^ . _:b446361270 "6"^^ . _:b446362826 . _:b446364628 . . _:b446362634 . _:b446361403 . _:b446364442 "2"^^ . _:b446361271 "6"^^ . _:b446362837 . _:b446361841 . _:b446361402 . _:b446364453 "2"^^ . . _:b446362836 . _:b446362439 . _:b446361268 "6"^^ . . _:b446361413 . _:b446364452 "2"^^ . _:b446361431 . _:b446361269 "6"^^ . _:b446362839 . . _:b446361412 . _:b446364455 "2"^^ . _:b446361266 "6"^^ . _:b446362838 . . _:b446361415 . _:b446364454 "2"^^ . _:b446361267 "6"^^ . _:b446362833 . _:b446361414 . _:b446364449 "2"^^ . _:b446361264 "6"^^ . _:b446362832 . _:b446361409 . _:b446364448 "2"^^ . _:b446363099 . _:b446361265 "6"^^ . _:b446362835 . _:b446361408 . _:b446364451 "2"^^ . _:b446361278 "6"^^ . _:b446362834 . . . . _:b446361411 . _:b446364450 "2"^^ . _:b446361279 "6"^^ . _:b446362845 . _:b446361410 . _:b446364461 "2"^^ . _:b446361880 . _:b446361276 "6"^^ . _:b446362844 . . _:b446361421 . _:b446364460 "2"^^ . _:b446361277 "6"^^ . _:b446362847 . . _:b446361420 . _:b446364463 "2"^^ . _:b446361274 "6"^^ . _:b446362846 . _:b446364450 . _:b446361423 . _:b446364462 "2"^^ . _:b446361275 "6"^^ . _:b446362841 . _:b446361422 . _:b446364457 "2"^^ . . _:b446362840 . _:b446361272 "6"^^ . . _:b446361417 . _:b446364456 "2"^^ . _:b446361273 "6"^^ . _:b446363464 . _:b446362843 . . _:b446364259 . _:b446361416 . _:b446364459 "2"^^ . _:b446362193 . _:b446361286 "6"^^ . _:b446362842 . _:b446361419 . _:b446364458 "2"^^ . _:b446361287 "6"^^ . _:b446363310 . _:b446362853 . _:b446361418 . _:b446364469 "2"^^ . _:b446361284 "6"^^ . _:b446362864 . _:b446362852 . . _:b446361429 . _:b446364468 "2"^^ . _:b446361285 "6"^^ . _:b446362855 . _:b446361428 . _:b446364471 "2"^^ . _:b446361282 "6"^^ . _:b446362854 . _:b446361431 . _:b446364470 "2"^^ . _:b446363178 . _:b446361283 "6"^^ . _:b446362849 . _:b446363980 . _:b446361430 . _:b446364465 "2"^^ . _:b446361280 "6"^^ . _:b446363495 . _:b446362848 . _:b446361425 . _:b446364464 "2"^^ . _:b446361281 "6"^^ . _:b446362851 . _:b446361424 . _:b446364467 "2"^^ . _:b446361294 "6"^^ . _:b446362850 . _:b446364356 . _:b446361427 . _:b446364466 "2"^^ . . _:b446364357 . _:b446364358 . _:b446362861 . _:b446361295 "6"^^ . _:b446364359 . _:b446364352 . . _:b446361426 . _:b446364477 "2"^^ . . _:b446364353 . _:b446364354 . _:b446362860 . _:b446361292 "6"^^ . _:b446364355 . _:b446364364 . _:b446361437 . _:b446364476 "2"^^ . _:b446363405 . _:b446364365 . _:b446364366 . _:b446362863 . _:b446361293 "6"^^ . _:b446364367 . _:b446361486 . . _:b446364360 . _:b446361436 . _:b446364479 "2"^^ . _:b446364361 . _:b446364362 . _:b446362862 . _:b446361290 "6"^^ . _:b446364363 . . _:b446364372 . _:b446361439 . _:b446364478 "2"^^ . _:b446364373 . _:b446364374 . _:b446364242 . _:b446362857 . _:b446361291 "6"^^ . _:b446364375 . _:b446364368 . _:b446361438 . _:b446364473 "2"^^ . _:b446364369 . _:b446361923 . _:b446362856 . _:b446361288 "6"^^ . _:b446364370 . _:b446364371 . _:b446364380 . . _:b446364472 "2"^^ . _:b446364381 . _:b446361433 . _:b446364382 . _:b446362859 . _:b446361289 "6"^^ . _:b446364383 . _:b446364376 . _:b446361432 . _:b446364475 "2"^^ . _:b446364377 . . _:b446362858 . _:b446361302 "6"^^ . _:b446364378 . _:b446364379 . _:b446363450 . _:b446364388 . _:b446361435 . _:b446364474 "2"^^ . _:b446364389 . _:b446361451 . _:b446362869 . . _:b446361303 "6"^^ . _:b446364390 . _:b446364391 . _:b446364384 . _:b446361283 . _:b446364485 "2"^^ . . _:b446364385 . _:b446361434 . _:b446364386 . _:b446362868 . _:b446361300 "6"^^ . . _:b446364387 . _:b446364396 . _:b446361445 . _:b446364484 "2"^^ . _:b446364397 . _:b446364398 . _:b446364132 . _:b446362871 . _:b446361301 "6"^^ . . _:b446364399 . _:b446364392 . _:b446361444 . _:b446364487 "2"^^ . _:b446364393 . _:b446364394 . _:b446362870 . _:b446361298 "6"^^ . _:b446364395 . . _:b446364404 . _:b446361447 . _:b446364486 "2"^^ . _:b446364405 . _:b446364406 . _:b446364120 . _:b446362865 . _:b446361299 "6"^^ . _:b446364407 . _:b446362998 . _:b446364400 . _:b446363817 . _:b446362773 . _:b446361446 . _:b446364481 "2"^^ . _:b446364401 . _:b446364402 . _:b446362864 . . _:b446361296 "6"^^ . _:b446364403 . _:b446364412 . _:b446361441 . _:b446364480 "2"^^ . _:b446362033 . _:b446364413 . _:b446364414 . _:b446362867 . . _:b446361297 "6"^^ . _:b446364415 . _:b446364408 . _:b446361440 . _:b446364483 "2"^^ . _:b446364409 . _:b446364410 . _:b446362866 . _:b446361310 "6"^^ . _:b446364411 . _:b446364292 . _:b446361443 . _:b446364482 "2"^^ . _:b446364293 . _:b446364294 . _:b446364039 . _:b446362877 . _:b446361311 "6"^^ . _:b446364295 . _:b446364288 . _:b446361442 . _:b446364493 "2"^^ . _:b446364289 . _:b446364290 . _:b446362876 . _:b446361308 "6"^^ . _:b446364291 . _:b446364300 . _:b446361453 . _:b446364492 "2"^^ . _:b446364028 . _:b446364301 . _:b446364302 . _:b446362879 . _:b446361309 "6"^^ . _:b446364303 . _:b446364296 . . _:b446361452 . _:b446364495 "2"^^ . _:b446364297 . _:b446364298 . _:b446362878 . _:b446361306 "6"^^ . _:b446364299 . _:b446364308 . _:b446361455 . _:b446364494 "2"^^ . _:b446364309 . _:b446364310 . _:b446362873 . _:b446361307 "6"^^ . _:b446364311 . _:b446364304 . _:b446361454 . _:b446364489 "2"^^ . _:b446364305 . . _:b446362872 . _:b446361304 "6"^^ . _:b446364306 . _:b446364307 . . _:b446364316 . . _:b446361449 . _:b446364488 "2"^^ . _:b446363549 . _:b446364317 . _:b446364318 . _:b446362958 . _:b446362875 . _:b446361305 "6"^^ . _:b446364319 . _:b446364312 . _:b446361448 . _:b446364491 "2"^^ . _:b446364313 . _:b446364314 . _:b446362874 . _:b446361318 "6"^^ . _:b446364315 . . _:b446364324 . _:b446361451 . _:b446364490 "2"^^ . _:b446364325 . . . _:b446362373 . _:b446361319 "6"^^ . _:b446364326 . _:b446364327 . _:b446364320 . _:b446361450 . _:b446364501 "2"^^ . _:b446364321 . 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_:b446361555 . _:b446364594 "2"^^ . _:b446363436 . _:b446361421 "5"^^ . _:b446363845 . _:b446363846 . _:b446362477 . _:b446363847 . _:b446361656 . _:b446363840 . _:b446361554 . _:b446364605 "2"^^ . _:b446361420 "5"^^ . _:b446363841 . . _:b446362476 . _:b446363842 . _:b446363843 . _:b446361892 . _:b446363852 . _:b446361565 . _:b446364604 "2"^^ . _:b446361423 "5"^^ . _:b446363853 . _:b446363854 . _:b446362479 . _:b446363855 . _:b446363848 . _:b446361564 . _:b446364607 "2"^^ . . _:b446361422 "5"^^ . _:b446363849 . _:b446363850 . _:b446362478 . _:b446363851 . _:b446363860 . _:b446361567 . _:b446364606 "2"^^ . _:b446361417 "5"^^ . _:b446363861 . _:b446363862 . _:b446362473 . _:b446363863 . _:b446363856 . _:b446361566 . _:b446364601 "2"^^ . _:b446361416 "5"^^ . _:b446363857 . _:b446363858 . _:b446362472 . _:b446363859 . _:b446363868 . _:b446361561 . _:b446364600 "2"^^ . _:b446361419 "5"^^ . _:b446363869 . _:b446363870 . _:b446362475 . _:b446363871 . _:b446363864 . _:b446361560 . _:b446364603 "2"^^ . _:b446363801 . _:b446361418 "5"^^ . _:b446363865 . _:b446363866 . _:b446362474 . _:b446363867 . _:b446363876 . _:b446361563 . _:b446364602 "2"^^ . _:b446361429 "5"^^ . _:b446363877 . . . _:b446363878 . _:b446362485 . _:b446362224 . . _:b446363879 . _:b446363872 . _:b446361562 . _:b446364613 "2"^^ . _:b446361428 "5"^^ . _:b446363873 . _:b446363874 . _:b446363815 . _:b446362484 . . _:b446363875 . _:b446363884 . _:b446361573 . _:b446364612 "2"^^ . _:b446361431 "5"^^ . _:b446363885 . _:b446363886 . _:b446362487 . _:b446363887 . _:b446363880 . _:b446361572 . _:b446364615 "2"^^ . _:b446361430 "5"^^ . _:b446363881 . _:b446363882 . _:b446362486 . _:b446363883 . _:b446363892 . _:b446363842 . _:b446361575 . _:b446364614 "2"^^ . _:b446361425 "5"^^ . _:b446363893 . _:b446363894 . _:b446362481 . _:b446363895 . _:b446363888 . _:b446361574 . _:b446364609 "2"^^ . _:b446361424 "5"^^ . _:b446363889 . _:b446363890 . _:b446362480 . _:b446361738 . _:b446363891 . _:b446363900 . _:b446361569 . _:b446364608 "2"^^ . . _:b446361427 "5"^^ . _:b446363901 . _:b446363902 . _:b446362483 . _:b446363903 . _:b446361873 . _:b446363896 . _:b446361568 . _:b446364611 "2"^^ . _:b446361426 "5"^^ . _:b446363897 . _:b446363898 . _:b446362482 . _:b446363899 . _:b446363780 . _:b446361571 . _:b446364610 "2"^^ . _:b446362316 . _:b446361437 "5"^^ . _:b446363781 . _:b446363782 . _:b446362493 . . _:b446363783 . _:b446363776 . _:b446361570 . _:b446364621 "2"^^ . _:b446363238 . _:b446361436 "5"^^ . _:b446363777 . _:b446363778 . _:b446363447 . _:b446362492 . . _:b446363779 . _:b446363788 . . _:b446361581 . _:b446364620 "2"^^ . _:b446361439 "5"^^ . _:b446363789 . _:b446363790 . _:b446362495 . . _:b446363791 . _:b446363784 . _:b446364256 . _:b446361580 . _:b446364623 "2"^^ . _:b446361438 "5"^^ . _:b446363785 . _:b446363786 . _:b446362494 . _:b446363787 . _:b446363796 . _:b446361583 . _:b446364622 "2"^^ . _:b446361433 "5"^^ . _:b446363797 . _:b446363798 . _:b446362489 . _:b446363799 . _:b446363475 . _:b446363792 . _:b446361582 . _:b446364617 "2"^^ . _:b446361432 "5"^^ . _:b446363793 . _:b446363794 . _:b446362488 . _:b446363795 . _:b446363804 . _:b446361577 . _:b446364616 "2"^^ . _:b446363228 . _:b446361435 "5"^^ . _:b446363805 . _:b446361553 . _:b446363806 . _:b446362491 . . _:b446363807 . _:b446363800 . _:b446362993 . _:b446361576 . _:b446364619 "2"^^ . _:b446361434 "5"^^ . _:b446363801 . _:b446363802 . _:b446362490 . _:b446363803 . _:b446363812 . _:b446361579 . _:b446364618 "2"^^ . _:b446363608 . . _:b446361445 "5"^^ . _:b446363813 . _:b446363814 . _:b446362501 . _:b446363815 . _:b446363808 . _:b446361578 . _:b446364629 "2"^^ . _:b446361444 "5"^^ . _:b446363809 . _:b446363810 . _:b446362500 . . _:b446363811 . _:b446363820 . _:b446361589 . _:b446364628 "2"^^ . _:b446361447 "5"^^ . _:b446363821 . _:b446363822 . _:b446362503 . _:b446363823 . _:b446363816 . _:b446361588 . _:b446364631 "2"^^ . _:b446361446 "5"^^ . _:b446363817 . _:b446363818 . _:b446362502 . _:b446363819 . _:b446363828 . _:b446361591 . _:b446364630 "2"^^ . . . _:b446361441 "5"^^ . _:b446363829 . . _:b446362497 . _:b446363830 . _:b446363831 . _:b446363824 . _:b446361590 . _:b446364625 "2"^^ . _:b446361440 "5"^^ . _:b446363825 . _:b446363826 . _:b446362496 . _:b446363827 . _:b446363836 . _:b446362684 . _:b446361585 . _:b446364624 "2"^^ . _:b446361443 "5"^^ . _:b446363837 . _:b446363838 . _:b446362499 . _:b446362158 . _:b446363839 . . _:b446363832 . _:b446361584 . _:b446364627 "2"^^ . _:b446361442 "5"^^ . _:b446363833 . . _:b446362498 . _:b446363834 . _:b446363835 . _:b446363716 . _:b446361587 . _:b446364626 "2"^^ . _:b446361453 "5"^^ . _:b446363717 . _:b446363718 . _:b446362509 . _:b446363719 . _:b446363712 . _:b446361586 . _:b446364637 "2"^^ . _:b446361452 "5"^^ . _:b446363713 . . _:b446363630 . _:b446362508 . _:b446363714 . _:b446360882 . _:b446363715 . _:b446363724 . _:b446361597 . _:b446364636 "2"^^ . _:b446361455 "5"^^ . _:b446363725 . . _:b446363726 . _:b446362511 . _:b446363727 . _:b446363720 . _:b446361596 . _:b446364639 "2"^^ . _:b446361454 "5"^^ . _:b446363721 . _:b446363722 . _:b446364655 . _:b446362510 . _:b446363723 . . . _:b446363732 . _:b446361599 . _:b446364638 "2"^^ . _:b446361449 "5"^^ . _:b446363733 . _:b446363734 . _:b446362505 . _:b446363735 . _:b446363728 . _:b446361598 . _:b446364633 "2"^^ . _:b446361448 "5"^^ . _:b446363729 . . _:b446362504 . _:b446363730 . _:b446363731 . _:b446363740 . _:b446362125 . _:b446361593 . _:b446364632 "2"^^ . _:b446361451 "5"^^ . _:b446363741 . _:b446363742 . _:b446362507 . _:b446363743 . _:b446363736 . _:b446361592 . _:b446364635 "2"^^ . _:b446361450 "5"^^ . _:b446363737 . _:b446361116 . . _:b446362506 . _:b446363738 . . _:b446363739 . _:b446362508 . _:b446363748 . _:b446362067 . . _:b446361595 . _:b446364634 "2"^^ . _:b446361461 "5"^^ . _:b446363749 . _:b446363750 . _:b446362517 . . _:b446363751 . _:b446363744 . . _:b446361594 . _:b446364645 "2"^^ . _:b446361460 "5"^^ . _:b446363745 . _:b446363746 . _:b446362516 . _:b446363747 . _:b446363832 . _:b446363756 . _:b446362183 . _:b446364644 "2"^^ . _:b446361463 "5"^^ . _:b446363757 . _:b446361093 . _:b446363758 . _:b446362519 . _:b446363759 . . . _:b446363752 . _:b446361092 . _:b446364647 "2"^^ . _:b446361462 "5"^^ . _:b446363753 . _:b446363754 . _:b446362518 . _:b446363755 . . _:b446363764 . _:b446361095 . _:b446364646 "2"^^ . _:b446361457 "5"^^ . _:b446363765 . _:b446363766 . _:b446362513 . . _:b446363767 . _:b446363760 . . _:b446361094 . _:b446364641 "2"^^ . _:b446361456 "5"^^ . _:b446363761 . _:b446363762 . _:b446362512 . _:b446363763 . _:b446363772 . _:b446361089 . _:b446364640 "2"^^ . _:b446361459 "5"^^ . _:b446363773 . _:b446363774 . _:b446362515 . _:b446363775 . _:b446362832 . _:b446363768 . _:b446363445 . _:b446361088 . _:b446364643 "2"^^ . _:b446361458 "5"^^ . _:b446363769 . _:b446363770 . _:b446362514 . _:b446363771 . _:b446363652 . _:b446361091 . _:b446364642 "2"^^ . _:b446361469 "5"^^ . _:b446363653 . _:b446363654 . _:b446362525 . _:b446363655 . _:b446363648 . . _:b446361090 . _:b9113983 . _:b446364653 "2"^^ . _:b446361468 "5"^^ . _:b446363649 . _:b446363650 . _:b446362524 . _:b446363651 . _:b446363660 . _:b446361101 . _:b446364652 "2"^^ . _:b446361471 "5"^^ . _:b446363661 . _:b446361097 . _:b446362527 . _:b446363662 . _:b446363663 . . _:b446363656 . _:b446361100 . _:b446364655 "2"^^ . _:b446361470 "5"^^ . _:b446363657 . _:b446363658 . _:b446362526 . _:b446363659 . _:b446363668 . _:b446361103 . _:b446364654 "2"^^ . _:b446361465 "5"^^ . _:b446363669 . _:b446363670 . _:b446362521 . _:b446363671 . _:b446361337 . _:b446363664 . _:b446363080 . . _:b446361102 . _:b446364649 "2"^^ . _:b446363072 . _:b446361464 "5"^^ . _:b446363665 . _:b446363666 . _:b446362520 . _:b446363667 . _:b446363676 . _:b446361097 . _:b446364648 "2"^^ . . _:b446361467 "5"^^ . _:b446363677 . _:b446363678 . _:b446362523 . _:b446363679 . . _:b446363289 . _:b446363672 . _:b446361096 . _:b446364651 "2"^^ . _:b446361466 "5"^^ . _:b446363673 . _:b446363674 . _:b446362522 . _:b446363675 . _:b446363684 . _:b446361099 . _:b446364650 "2"^^ . _:b446364065 . _:b446361286 . _:b446361477 "5"^^ . _:b446363685 . _:b446363686 . _:b446362533 . _:b446363687 . _:b446363680 . _:b446361098 . _:b446364661 "2"^^ . _:b446361476 "5"^^ . _:b446363681 . _:b446363682 . _:b446362532 . . _:b446363683 . _:b446363692 . _:b446361109 . _:b446364660 "2"^^ . _:b446361479 "5"^^ . _:b446363693 . _:b446363694 . _:b446362535 . _:b446363695 . _:b446363688 . . _:b446361108 . _:b446364663 "2"^^ . _:b446361478 "5"^^ . _:b446363689 . _:b446363690 . _:b446364402 . _:b446362534 . _:b446361173 . _:b446363691 . _:b446363700 . _:b446362734 . . _:b446364662 "2"^^ . _:b446361473 "5"^^ . _:b446363701 . _:b446361111 . . _:b446362529 . _:b446363702 . _:b446363703 . _:b446363696 . _:b446361110 . _:b446364657 "2"^^ . _:b446361472 "5"^^ . _:b446363697 . _:b446363698 . _:b446362528 . _:b446363699 . _:b446363920 . _:b446363708 . _:b446361105 . _:b446364656 "2"^^ . . _:b446361475 "5"^^ . _:b446363709 . _:b446363710 . _:b446362531 . _:b446363711 . . _:b446363704 . _:b446361104 . _:b446364659 "2"^^ . _:b446361474 "5"^^ . _:b446363705 . _:b446363706 . _:b446362530 . _:b446363707 . _:b446364100 . _:b446361107 . _:b446364658 "2"^^ . _:b446361485 "5"^^ . _:b446364101 . _:b446364102 . _:b446362541 . . _:b446364103 . _:b446362093 . _:b446364096 . _:b446361106 . _:b446364669 "2"^^ . _:b446361484 "5"^^ . _:b446361044 . _:b446364097 . _:b446364098 . _:b446362540 . . _:b446364099 . . _:b446364108 . _:b446361117 . _:b446364668 "2"^^ . _:b446361487 "5"^^ . _:b446364109 . _:b446361598 . _:b446362543 . _:b446364110 . _:b446364111 . _:b446364149 . . _:b446364104 . _:b446364319 . _:b446362911 . _:b446361116 . _:b446361486 "5"^^ . _:b446364105 . _:b446364106 . _:b446362542 . _:b446364107 . _:b446364116 . _:b446361119 . _:b446364670 "2"^^ . _:b446361481 "5"^^ . _:b446364117 . _:b446364118 . _:b446362537 . _:b446364119 . _:b446364112 . _:b446361118 . _:b446364665 "2"^^ . _:b446361480 "5"^^ . _:b446364113 . _:b446364114 . _:b446362735 . _:b446362536 . _:b446364115 . _:b446364124 . _:b446361398 . _:b446361113 . _:b446364664 "2"^^ . _:b446361483 "5"^^ . _:b446364125 . _:b446364126 . _:b446362539 . _:b446364127 . _:b446364120 . _:b446361112 . _:b446364667 "2"^^ . _:b446361482 "5"^^ . _:b446364121 . _:b446364122 . _:b446362538 . _:b446364123 . _:b446364132 . _:b446361115 . _:b446364666 "2"^^ . _:b446361493 "5"^^ . _:b446364133 . _:b446364134 . _:b446362549 . _:b446364135 . . _:b446364128 . _:b446361114 . _:b446363653 "2"^^ . _:b446361492 "5"^^ . _:b446364129 . _:b446360946 . _:b446362548 . _:b446364130 . _:b446364131 . _:b446363047 . _:b446364140 . _:b446361125 . _:b446363652 "2"^^ . _:b446361495 "5"^^ . _:b446364141 . . _:b446362551 . _:b446364142 . . _:b446364143 . _:b446364136 . . _:b446363655 "2"^^ . _:b446361494 "5"^^ . _:b446364137 . _:b446361124 . . _:b446364138 . _:b446362550 . _:b446364139 . _:b446364148 . _:b446361127 . _:b446363654 "2"^^ . _:b446362986 . _:b446361489 "5"^^ . _:b446364149 . _:b446364150 . _:b446362545 . _:b446364151 . _:b446364144 . _:b446361126 . _:b446363649 "2"^^ . _:b446361488 "5"^^ . _:b446364145 . . _:b446364146 . _:b446362544 . _:b446364147 . . _:b446364156 . _:b446361121 . _:b446363648 "2"^^ . _:b446361491 "5"^^ . _:b446364157 . _:b446364158 . _:b446362547 . . _:b446364159 . _:b446364152 . _:b446361120 . _:b446363651 "2"^^ . _:b446361490 "5"^^ . _:b446364153 . _:b446364154 . _:b446362546 . _:b446364155 . _:b446364036 . _:b446361123 . _:b446363650 "2"^^ . _:b446361501 "5"^^ . _:b446364037 . _:b446364038 . _:b446362557 . _:b446364039 . _:b446363906 . _:b446364032 . _:b446361122 . _:b446363661 "2"^^ . _:b446361500 "5"^^ . _:b446364033 . . _:b446364034 . _:b446362556 . _:b446364035 . _:b446364044 . _:b446361133 . _:b446363660 "2"^^ . _:b446361503 "5"^^ . _:b446364045 . . _:b446362559 . _:b446364046 . _:b446364047 . . _:b446364040 . _:b446361132 . _:b446363663 "2"^^ . _:b446363109 . _:b446361502 "5"^^ . _:b446364041 . _:b446364042 . _:b446362558 . _:b446364043 . _:b446364239 . _:b446361715 . _:b446364052 . _:b446360903 . _:b446363662 "2"^^ . _:b446361497 "5"^^ . _:b446364053 . _:b446361135 . _:b446364054 . _:b446362553 . _:b446364055 . _:b446364048 . _:b446361134 . _:b446363657 "2"^^ . _:b446361496 "5"^^ . _:b446361743 . _:b446364049 . . _:b446362552 . _:b446361267 . _:b446364050 . _:b446364051 . . _:b446364060 . _:b446361129 . _:b446363656 "2"^^ . _:b446361499 "5"^^ . _:b446364061 . . _:b446364062 . _:b446362555 . _:b446364063 . _:b446364056 . _:b446363602 . _:b446361128 . _:b446363659 "2"^^ . _:b446361498 "5"^^ . _:b446364057 . _:b446364058 . _:b446362554 . _:b446364059 . _:b446364068 . _:b446361131 . _:b446363658 "2"^^ . _:b446361509 "5"^^ . _:b446364069 . _:b446364070 . _:b446362565 . _:b446364071 . _:b446364064 . _:b446361130 . _:b446363669 "2"^^ . _:b446361508 "5"^^ . _:b446364065 . . _:b446364066 . _:b446362564 . . . _:b446364067 . _:b446364076 . _:b446361141 . _:b446363668 "2"^^ . _:b446361511 "5"^^ . _:b446364077 . . _:b446364078 . _:b446362567 . . _:b446364079 . _:b446364072 . _:b446361140 . _:b446363671 "2"^^ . _:b446363302 . _:b446361510 "5"^^ . _:b446364073 . _:b446364074 . _:b446362566 . _:b446364075 . _:b446364084 . . _:b446361143 . _:b446363670 "2"^^ . _:b446361505 "5"^^ . _:b446364085 . _:b446364086 . _:b446362561 . _:b446364087 . _:b446364080 . _:b446361142 . _:b446363665 "2"^^ . _:b446361504 "5"^^ . _:b446364081 . _:b446364082 . _:b446364177 . _:b446363282 . _:b446362611 . _:b446362560 . . _:b446364083 . _:b446364092 . . _:b446361736 . _:b446363664 "2"^^ . _:b446361507 "5"^^ . _:b446364093 . _:b446361137 . _:b446364094 . _:b446362563 . _:b446364095 . _:b446364088 . _:b446364459 . _:b446361136 . _:b446363667 "2"^^ . _:b446361506 "5"^^ . _:b446364089 . . _:b446362562 . . _:b446364090 . . _:b446364091 . _:b446363972 . _:b446361517 "4"^^ . _:b446361139 . _:b446363666 "2"^^ . _:b446363973 . _:b446363974 . _:b446362573 . _:b446363975 . . _:b446363968 . _:b446361138 . _:b446363677 "2"^^ . _:b446361516 "5"^^ . _:b446363969 . _:b446363970 . _:b446362572 . _:b446361190 . . _:b446363971 . _:b446363980 . _:b446361744 . _:b446361519 "4"^^ . _:b446361149 . _:b446363676 "2"^^ . _:b446363981 . _:b446361571 . _:b446363982 . _:b446362575 . _:b446363983 . _:b446361589 . _:b446363976 . _:b446361518 "4"^^ . . _:b446363679 "2"^^ . _:b446363977 . _:b446361148 . _:b446363978 . _:b446362574 . _:b446363979 . _:b446361182 . _:b446363988 . _:b446361151 . _:b446364396 . _:b446363678 "2"^^ . _:b446361513 "5"^^ . _:b446363989 . _:b446363990 . _:b446362569 . _:b446363991 . _:b446363984 . _:b446361150 . _:b446363673 "2"^^ . _:b446361512 "5"^^ . _:b446363985 . _:b446363986 . _:b446362568 . _:b446363987 . _:b446363996 . _:b446361145 . _:b446363672 "2"^^ . _:b446361515 "5"^^ . _:b446363997 . _:b446363998 . _:b446362571 . _:b446363999 . _:b446363992 . _:b446361144 . _:b446363675 "2"^^ . _:b446361514 "5"^^ . _:b446363993 . _:b446363994 . _:b446362570 . _:b446363995 . _:b446364004 . _:b446361525 "4"^^ . . _:b446363674 "2"^^ . _:b446364005 . _:b446361147 . _:b446364006 . _:b446362581 . _:b446364007 . _:b446364000 . _:b446361524 "4"^^ . _:b446361146 . _:b446363685 "2"^^ . _:b446364001 . . _:b446362580 . _:b446364002 . _:b446364003 . _:b446364012 . _:b446361527 "4"^^ . _:b446361157 . _:b446363684 "2"^^ . _:b446364013 . _:b446364014 . _:b446362583 . _:b446362069 . _:b446364015 . . _:b446364008 . _:b446363670 . _:b446361526 "4"^^ . _:b446361156 . _:b446363687 "2"^^ . _:b446363055 . _:b446364009 . _:b446364010 . _:b446362758 . _:b446362582 . _:b446364011 . _:b446364020 . _:b446361521 "4"^^ . _:b446361159 . _:b446363686 "2"^^ . _:b446364021 . _:b446364022 . _:b446362577 . _:b446364023 . . _:b446361520 "4"^^ . _:b446364016 . _:b446361158 . _:b446363681 "2"^^ . _:b446364017 . _:b446364018 . _:b446363369 . _:b446362576 . _:b446364019 . . _:b446361523 "4"^^ . _:b446364028 . _:b446361644 . _:b446361153 . _:b446363680 "2"^^ . _:b446364029 . _:b446364030 . _:b446362579 . _:b446364031 . _:b446364024 . _:b446361522 "4"^^ . _:b446361152 . _:b446363683 "2"^^ . _:b446364025 . _:b446361508 . . _:b446362578 . _:b446364026 . _:b446362074 . _:b446364027 . _:b446363908 . _:b446361533 "4"^^ . _:b446361155 . _:b446363682 "2"^^ . _:b446363909 . _:b446363910 . _:b446362589 . _:b446361801 . _:b446363911 . _:b446363904 . _:b446361532 "4"^^ . _:b446361154 . _:b446363693 "2"^^ . _:b446363905 . _:b446363906 . _:b446364457 . _:b446362588 . _:b446363907 . _:b446363598 . . _:b446363390 . . _:b446361535 "4"^^ . _:b446363916 . _:b446361165 . _:b446364552 . _:b446363692 "2"^^ . . _:b446363917 . _:b446363918 . _:b446362591 . _:b446363919 . _:b446363912 . _:b446361534 "4"^^ . _:b446361164 . _:b446363695 "2"^^ . _:b446363913 . _:b446363914 . _:b446362590 . _:b446363915 . _:b446363924 . _:b446361529 "4"^^ . _:b446361167 . _:b446363694 "2"^^ . _:b446363925 . _:b446363926 . _:b446362585 . _:b446362412 . _:b446363927 . _:b446363920 . _:b446361528 "4"^^ . _:b446361166 . _:b446363689 "2"^^ . _:b446363921 . . _:b446362584 . _:b446363922 . _:b446363923 . _:b446363932 . _:b446361531 "4"^^ . _:b446361161 . _:b446363688 "2"^^ . _:b446363933 . _:b446363934 . _:b446362587 . _:b446363935 . _:b446363928 . _:b446361530 "4"^^ . _:b446361160 . _:b446363691 "2"^^ . _:b446363929 . . _:b446362586 . _:b446363930 . _:b446363931 . _:b446362559 . _:b446363940 . _:b446361541 "4"^^ . _:b446361163 . _:b446363690 "2"^^ . _:b446363941 . _:b446363942 . _:b446362597 . . _:b446363943 . _:b446363936 . _:b446361540 "4"^^ . _:b446361162 . _:b446364162 . _:b446363701 "2"^^ . _:b446363937 . _:b446363938 . _:b446362596 . _:b446363939 . _:b446363948 . _:b446361543 "4"^^ . _:b446361173 . _:b446363700 "2"^^ . _:b446363949 . _:b446362187 . _:b446362599 . _:b446363950 . _:b446363951 . _:b446363944 . _:b446361542 "4"^^ . _:b446361172 . _:b446363703 "2"^^ . _:b446363358 . _:b446363945 . _:b446363946 . _:b446362598 . _:b446363947 . _:b446363956 . _:b446361537 "4"^^ . _:b446361175 . _:b446363702 "2"^^ . _:b446363957 . . _:b446363958 . _:b446362593 . . _:b446363959 . . _:b446363952 . _:b446361536 "4"^^ . _:b446361174 . _:b446363697 "2"^^ . _:b446363953 . _:b446363954 . _:b446362592 . . _:b446363955 . _:b446362180 . _:b446363964 . _:b446361539 "4"^^ . _:b446361169 . _:b446363696 "2"^^ . _:b446363965 . . _:b446362595 . _:b446363966 . _:b446363967 . _:b446363960 . _:b446361538 "4"^^ . _:b446361168 . _:b446363699 "2"^^ . _:b446363961 . _:b446363962 . _:b446362594 . _:b446363963 . _:b446364535 . _:b446364264 . _:b446363332 . _:b9113984 "This estimate is consistent with the average cell doubling time in pancreatic cancer from Amikura et al. >>20<< of 2.3 days." . _:b446363471 . _:b446361549 "4"^^ . _:b446361171 . _:b446364066 . _:b446363698 "2"^^ . _:b446363333 . _:b446363334 . _:b446362605 . _:b446363335 . _:b446363328 . _:b446361548 "4"^^ . _:b446361170 . _:b446363709 "2"^^ . _:b446363329 . _:b446363330 . _:b446363116 . _:b446362604 . _:b446363331 . _:b446362273 . _:b446361551 "4"^^ . _:b446363340 . . _:b446361181 . _:b446363708 "2"^^ . _:b446363341 . _:b446363342 . _:b446362607 . . _:b446364224 . _:b446362539 . _:b446363343 . _:b446363336 . _:b446361550 "4"^^ . _:b446361180 . _:b446363711 "2"^^ . _:b446363337 . _:b446363338 . _:b446362606 . _:b446363339 . _:b446361675 . _:b446363348 . _:b446361545 "4"^^ . _:b446361183 . _:b446363710 "2"^^ . _:b446363349 . . _:b446362960 . _:b446362601 . _:b446363350 . _:b446363351 . _:b446363344 . _:b446363440 . _:b446361544 "4"^^ . _:b446361182 . _:b446363705 "2"^^ . _:b446363345 . _:b446363346 . _:b446362600 . _:b446363347 . _:b446363356 . _:b446361547 "4"^^ . _:b446361177 . _:b446363704 "2"^^ . _:b446363357 . _:b446363358 . _:b446362603 . _:b446363359 . _:b446363152 . _:b446362403 . _:b446363352 . _:b446361546 "4"^^ . _:b446361176 . _:b446363707 "2"^^ . _:b446363353 . _:b446363354 . _:b446362602 . _:b446363355 . _:b446363364 . _:b446361557 "4"^^ . _:b446361179 . _:b446363706 "2"^^ . _:b446363365 . . _:b446363366 . _:b446362613 . _:b446363367 . _:b446363360 . _:b446361556 "4"^^ . _:b446361178 . _:b446363717 "2"^^ . _:b446363361 . _:b446363362 . _:b446362674 . _:b446362612 . _:b446363363 . _:b446363372 . _:b446361559 "4"^^ . . _:b446364283 . _:b446363716 "2"^^ . _:b446363373 . _:b446361189 . _:b446363374 . _:b446362615 . _:b446363375 . _:b446363368 . _:b446362982 . _:b446361558 "4"^^ . _:b446361188 . _:b446363719 "2"^^ . _:b446363369 . . _:b446362614 . _:b446363370 . _:b446363371 . _:b446361343 . _:b446363380 . _:b446361553 "4"^^ . _:b446361191 . _:b446363718 "2"^^ . _:b446363381 . _:b446363382 . _:b446362609 . _:b446363383 . _:b446363376 . _:b446361552 "4"^^ . _:b446361190 . _:b446363713 "2"^^ . _:b446363377 . _:b446363378 . _:b446362608 . _:b446363379 . _:b446363388 . _:b446361555 "4"^^ . _:b446361185 . _:b446363712 "2"^^ . _:b446363389 . _:b446363390 . _:b446362611 . _:b446363391 . . _:b446363384 . _:b446361554 "4"^^ . _:b446361184 . _:b446363715 "2"^^ . _:b446361025 . _:b446363385 . _:b446363386 . _:b446362610 . _:b446363387 . _:b446363268 . _:b446361565 "4"^^ . _:b446361187 . _:b446363714 "2"^^ . _:b446363269 . _:b446363270 . _:b446362621 . _:b446363271 . _:b446363264 . _:b446361564 "4"^^ . _:b446361383 . _:b446361186 . _:b446363725 "2"^^ . _:b446363265 . . _:b446362620 . _:b446363266 . . _:b446363205 . _:b446363196 . _:b446363267 . . _:b446361567 "4"^^ . _:b446363276 . _:b446361197 . _:b446363724 "2"^^ . _:b446363277 . _:b446363278 . _:b446362623 . _:b446363279 . _:b446362939 . _:b446363272 . _:b446361566 "4"^^ . _:b446361196 . _:b446363727 "2"^^ . _:b446363273 . _:b446363274 . _:b446362622 . _:b446363275 . _:b446361221 . _:b446361561 "4"^^ . _:b446363284 . _:b446361199 . _:b446363726 "2"^^ . _:b446363285 . _:b446363286 . _:b446362617 . _:b446363287 . . _:b446361560 "4"^^ . _:b446363280 . _:b446361198 . _:b446363721 "2"^^ . _:b446363281 . _:b446363282 . _:b446362616 . . _:b446363283 . _:b446363292 . _:b446361563 "4"^^ . _:b446361193 . _:b446363720 "2"^^ . _:b446363376 . _:b446363293 . . _:b446363294 . _:b446362619 . . _:b446363295 . _:b446363288 . _:b446361562 "4"^^ . _:b446361192 . _:b446363723 "2"^^ . _:b446363289 . _:b446363290 . _:b446362618 . _:b446363291 . _:b446363300 . _:b446362529 . _:b446361573 "4"^^ . . _:b446363722 "2"^^ . _:b446363301 . _:b446361195 . _:b446362117 . . _:b446363302 . _:b446363303 . _:b446363296 . _:b446361572 "4"^^ . _:b446361194 . _:b446363949 . _:b446363733 "2"^^ . _:b446363297 . _:b446362116 . . _:b446363298 . _:b446363299 . _:b446363308 . _:b446361575 "4"^^ . _:b446361205 . _:b446363732 "2"^^ . _:b446363483 . _:b446363309 . . _:b446362119 . _:b446363575 . _:b446363310 . _:b446363311 . _:b446363304 . _:b446361574 "4"^^ . _:b446361204 . _:b446363735 "2"^^ . _:b446363305 . _:b446362118 . _:b446363306 . _:b446363307 . _:b446363316 . _:b446361569 "4"^^ . _:b446361207 . _:b446363734 "2"^^ . _:b446363317 . _:b446362113 . _:b446363318 . _:b446363319 . . . _:b446361568 "4"^^ . _:b446363312 . _:b446361206 . _:b446363729 "2"^^ . _:b446363313 . _:b446362112 . _:b446363314 . _:b446363315 . _:b446363324 . _:b446361571 "4"^^ . _:b446361201 . _:b446363728 "2"^^ . _:b446363325 . _:b446362115 . _:b446364064 . _:b446363326 . . _:b446363327 . _:b446363320 . _:b446363501 . _:b446361570 "4"^^ . _:b446361200 . _:b446363731 "2"^^ . _:b446363321 . _:b446362114 . _:b446363322 . _:b446363323 . . _:b446361581 "4"^^ . _:b446363204 . _:b446361203 . _:b446363730 "2"^^ . _:b446363205 . _:b446362125 . _:b446363206 . . _:b446363207 . _:b446363200 . _:b446361580 "4"^^ . . _:b446361202 . _:b446363741 "2"^^ . _:b446363201 . _:b446362124 . _:b446363202 . . _:b446363203 . _:b446363212 . _:b446361583 "4"^^ . _:b446361213 . _:b446363740 "2"^^ . _:b446363213 . _:b446362127 . _:b446363214 . . _:b446360864 . _:b446363215 . _:b446363208 . _:b446361582 "4"^^ . _:b446361212 . _:b446363743 "2"^^ . _:b446363209 . _:b446362126 . _:b446363210 . _:b446362098 . . _:b446363211 . _:b446363220 . _:b446361577 "4"^^ . _:b446361215 . _:b446363742 "2"^^ . _:b446363221 . _:b446362121 . _:b446363222 . _:b446361230 . . . _:b446363223 . _:b446363216 . . _:b446361576 "4"^^ . _:b446361214 . _:b446363737 "2"^^ . _:b446363217 . _:b446362120 . _:b446363218 . _:b446363219 . _:b446364663 . _:b446363228 . _:b446361579 "4"^^ . _:b446361209 . _:b446363736 "2"^^ . _:b446363229 . . _:b446362123 . _:b446363230 . _:b446363231 . _:b446363224 . _:b446361578 "4"^^ . _:b446361208 . _:b446363739 "2"^^ . _:b446362481 . _:b446363225 . _:b446362122 . _:b446363226 . _:b446363227 . _:b446363236 . _:b446361589 "4"^^ . _:b446361211 . _:b446363738 "2"^^ . _:b446363237 . _:b446362133 . . _:b446363238 . _:b446362296 . _:b446363239 . _:b446363232 . _:b446361588 "4"^^ . _:b446361210 . _:b446363749 "2"^^ . _:b446363233 . _:b446362132 . _:b446363234 . _:b446363235 . . _:b446364193 . _:b446363193 . _:b446361591 "4"^^ . _:b446363244 . _:b446361221 . _:b446363748 "2"^^ . _:b446363245 . _:b446362135 . _:b446363246 . _:b446363247 . _:b446363240 . _:b446361590 "4"^^ . _:b446361220 . _:b446363751 "2"^^ . _:b446363241 . _:b446362134 . _:b446363242 . _:b446363243 . _:b446363252 . _:b446361585 "4"^^ . _:b446361223 . _:b446363750 "2"^^ . _:b446363253 . _:b446362129 . _:b446363254 . _:b446363255 . _:b446363248 . _:b446361584 "4"^^ . _:b446361222 . _:b446363745 "2"^^ . _:b446363249 . _:b446362128 . . _:b446363250 . _:b446363251 . _:b446364583 . _:b446363260 . _:b446361587 "4"^^ . _:b446361217 . _:b446363744 "2"^^ . . _:b446363261 . _:b446361214 . _:b446362131 . _:b446363262 . _:b446363263 . _:b446363256 . _:b446361586 "4"^^ . _:b446361216 . _:b446363747 "2"^^ . _:b446363257 . _:b446362130 . _:b446363258 . _:b446363259 . _:b446363140 . _:b446363344 . _:b446361597 "4"^^ . _:b446361219 . _:b446363746 "2"^^ . _:b446363141 . _:b446362141 . _:b446361394 . _:b446363142 . _:b446363143 . _:b446362226 . _:b446361596 "4"^^ . _:b446363136 . _:b446361218 . _:b446363757 "2"^^ . _:b446363137 . _:b446362140 . _:b446363138 . _:b446363139 . _:b446363148 . _:b446361599 "4"^^ . _:b446361229 . _:b446363756 "2"^^ . _:b446363149 . _:b446362143 . _:b446363150 . _:b446363151 . _:b446363144 . _:b446361598 "4"^^ . _:b446361228 . _:b446363759 "2"^^ . _:b446363145 . _:b446362142 . _:b446363146 . _:b446363147 . _:b446363156 . _:b446361593 "4"^^ . _:b446361231 . _:b446363758 "2"^^ . _:b446363157 . _:b446362137 . _:b446363158 . _:b446363159 . _:b446363152 . _:b446361592 "4"^^ . _:b446361230 . _:b446363753 "2"^^ . _:b446363153 . _:b446362136 . _:b446363154 . _:b446361137 . _:b446363155 . _:b446363164 . _:b446361595 "4"^^ . _:b446361225 . _:b446363752 "2"^^ . _:b446363147 . _:b446363165 . _:b446362139 . _:b446363166 . _:b446363167 . _:b446363160 . _:b446361594 "4"^^ . _:b446361224 . _:b446363755 "2"^^ . _:b446363161 . _:b446362138 . . _:b446363162 . . _:b446363163 . _:b446363172 . _:b446361227 . _:b446363754 "2"^^ . _:b446363173 . _:b446362149 . _:b446363174 . _:b446363175 . _:b446363168 . _:b446361226 . _:b446363765 "2"^^ . _:b446363169 . _:b446362148 . _:b446363170 . _:b446363171 . _:b446362050 . _:b446363180 . . . _:b446361237 . _:b446363764 "2"^^ . _:b446361768 . _:b446363181 . _:b446362151 . _:b446363182 . . _:b446363183 . _:b446361174 . _:b446361867 . _:b446363176 . _:b446361807 . _:b446363767 "2"^^ . _:b446363177 . . _:b446361236 . _:b446362150 . _:b446363178 . _:b446363179 . _:b446363188 . _:b446361239 . _:b446363766 "2"^^ . _:b446363189 . _:b446362145 . _:b446363190 . _:b446363191 . _:b446363184 . _:b446361238 . _:b446363761 "2"^^ . _:b446363185 . _:b446362144 . _:b446363186 . _:b446363187 . _:b446363196 . . _:b446363760 "2"^^ . _:b446363197 . _:b446361233 . _:b446362147 . _:b446363198 . _:b446363199 . _:b446363192 . _:b446362732 . _:b446361232 . _:b446363763 "2"^^ . _:b446363193 . _:b446362146 . _:b446363194 . _:b446363195 . _:b446363588 . . _:b446361235 . _:b446363762 "2"^^ . _:b446363589 . _:b446362157 . _:b446363590 . _:b446363591 . _:b446362290 . _:b446363584 . _:b446361234 . _:b446363773 "2"^^ . _:b446363585 . _:b446362156 . _:b446363586 . _:b446363587 . . _:b446363596 . _:b446361245 . _:b446363772 "2"^^ . _:b446363597 . _:b446362159 . _:b446363598 . _:b446363599 . _:b446363592 . _:b446361244 . _:b446363775 "2"^^ . _:b446363593 . _:b446362158 . _:b446363594 . _:b446363595 . _:b446363604 . _:b446361247 . _:b446363774 "2"^^ . _:b446363605 . _:b446362153 . _:b446363606 . _:b446363607 . . _:b446363600 . _:b446361246 . _:b446363769 "2"^^ . _:b446363601 . . _:b446363602 . _:b446362152 . _:b446363603 . _:b446363612 . _:b446361241 . _:b446363768 "2"^^ . _:b446363613 . . _:b446362155 . _:b446363614 . _:b446363615 . _:b446363608 . _:b446361240 . _:b446363771 "2"^^ . _:b446363609 . _:b446362154 . _:b446363997 . _:b446363610 . _:b446363611 . . _:b446363620 . _:b446361243 . _:b446363770 "2"^^ . _:b446363621 . _:b446362165 . _:b446363622 . _:b446363623 . . _:b446363616 . _:b446361242 . _:b446363781 "2"^^ . _:b446363617 . _:b446362164 . _:b446363618 . _:b446363619 . . _:b446363628 . _:b446361253 . _:b446363780 "2"^^ . _:b446363629 . _:b446362167 . _:b446363630 . _:b446363631 . _:b446363624 . _:b446361252 . _:b446363783 "2"^^ . _:b446363625 . _:b446362166 . _:b446363626 . . _:b446361250 . _:b446363627 . _:b446363636 . _:b446361255 . _:b446363782 "2"^^ . _:b446362511 . _:b446363637 . _:b446362161 . _:b446363638 . _:b446363639 . _:b446363632 . _:b446361254 . _:b446363953 . _:b446363777 "2"^^ . _:b446363633 . . _:b446363634 . _:b446362160 . _:b446363635 . _:b446363644 . _:b446361249 . _:b446363776 "2"^^ . _:b446363645 . _:b446362163 . _:b446363646 . _:b446363647 . . _:b446363640 . _:b446362086 . _:b446363973 . _:b446363779 "2"^^ . _:b446362404 . . _:b446363641 . _:b446361248 . _:b446362162 . _:b446363642 . _:b446363643 . _:b446363524 . _:b446361251 . _:b446363778 "2"^^ . _:b446363525 . _:b446362173 . _:b446363526 . . _:b446361986 . _:b446363527 . _:b446363520 . _:b446361250 . _:b446363789 "2"^^ . _:b446363521 . _:b446362172 . _:b446363522 . _:b446363523 . _:b446363532 . _:b446361261 . _:b446363788 "2"^^ . _:b446363533 . _:b446362175 . _:b446363534 . _:b446363535 . _:b446363528 . _:b446361260 . _:b446363791 "2"^^ . _:b446363529 . _:b446362174 . _:b446363530 . . _:b446363531 . _:b446363540 . _:b446362210 . _:b446363790 "2"^^ . _:b446363541 . _:b446361263 . . _:b446363990 . _:b446363542 . _:b446362169 . _:b446363543 . _:b446363476 . _:b446363536 . _:b446361262 . _:b446363785 "2"^^ . _:b446363537 . . _:b446362168 . _:b446363538 . _:b446363539 . _:b446363714 . _:b446362166 . _:b446363548 . . _:b446363784 "2"^^ . _:b446363549 . _:b446361257 . _:b446362171 . . _:b446363550 . _:b446360977 . _:b446363551 . _:b446361726 . _:b446362714 . _:b446363544 . . _:b446361256 . _:b446363787 "2"^^ . _:b446362825 . _:b446363545 . _:b446362170 . . _:b446363546 . _:b446363547 . _:b446363556 . _:b446361259 . _:b446363786 "2"^^ . _:b446363557 . _:b446362181 . _:b446363332 . _:b446363558 . _:b446363559 . _:b446363552 . _:b446361258 . _:b446363797 "2"^^ . _:b446363553 . _:b446362180 . _:b446363554 . _:b446363555 . . _:b446363564 . _:b446361269 . _:b446363796 "2"^^ . _:b446363565 . _:b446362183 . _:b446363566 . . _:b446363567 . _:b446363560 . _:b446361268 . _:b446363799 "2"^^ . _:b446363561 . _:b446362182 . _:b446363562 . _:b446363563 . _:b446363572 . _:b446361271 . _:b446363798 "2"^^ . _:b446363573 . _:b446362177 . _:b446363574 . _:b446363575 . _:b446363568 . _:b446361270 . _:b446363793 "2"^^ . _:b446363569 . _:b446362176 . _:b446363570 . _:b446363571 . . _:b446363580 . _:b446361265 . _:b446363792 "2"^^ . . _:b446363581 . _:b446362179 . _:b446363582 . . _:b446363583 . _:b446363576 . _:b446361264 . _:b446363795 "2"^^ . _:b446363577 . _:b446362178 . . _:b446363578 . _:b446363579 . _:b446363519 . _:b446363460 . _:b446363172 . . _:b446363794 "2"^^ . _:b446363461 . _:b446361267 . _:b446362189 . _:b446363518 . _:b446363462 . _:b446363463 . . _:b446363456 . _:b446361266 . _:b446363805 "2"^^ . _:b446363457 . _:b446362188 . _:b446363458 . _:b446363459 . _:b446363468 . _:b446361277 . _:b446363804 "2"^^ . _:b446362874 . _:b446363469 . _:b446362191 . _:b446363470 . _:b446361466 . _:b446363471 . _:b446363464 . _:b446361276 . _:b446363807 "2"^^ . _:b446363465 . _:b446362190 . _:b446363466 . _:b446363467 . _:b446363476 . _:b446361279 . _:b446363806 "2"^^ . _:b446363477 . _:b446362208 . _:b446364044 . _:b446363478 . _:b446362185 . _:b446363479 . _:b446363472 . _:b446361278 . _:b446363801 "2"^^ . _:b446363473 . _:b446362184 . _:b446363474 . _:b446363475 . _:b446360969 . _:b446363484 . _:b446361273 . _:b446363800 "2"^^ . _:b446363485 . _:b446362187 . _:b446363486 . . _:b446363487 . _:b446364153 . _:b446363480 . _:b446361272 . _:b446363803 "2"^^ . _:b446363292 . _:b446363481 . _:b446362186 . _:b446363482 . _:b446363483 . _:b446361334 . _:b446363492 . _:b446361275 . _:b446363802 "2"^^ . _:b446363493 . _:b446362197 . _:b446363494 . _:b446363495 . _:b446363488 . _:b446361274 . _:b446363813 "2"^^ . _:b446363489 . _:b446362196 . _:b446363490 . _:b446363491 . _:b446363500 . _:b446361285 . _:b446363812 "2"^^ . _:b446363501 . _:b446362199 . _:b446363502 . _:b446363503 . _:b446363496 . _:b446362801 . _:b446361284 . _:b446363815 "2"^^ . _:b446363497 . _:b446361435 . _:b446362198 . _:b446363498 . _:b446363499 . _:b446362625 . _:b446363508 . _:b446361287 . _:b446363814 "2"^^ . _:b446363509 . _:b446362193 . _:b446362091 . _:b446363510 . _:b446363511 . _:b446363504 . _:b446361286 . _:b446363809 "2"^^ . _:b446362626 . _:b446363505 . _:b446362192 . _:b446363506 . _:b446362297 . . _:b446363507 . _:b446362186 . _:b446363516 . _:b446361281 . _:b446363808 "2"^^ . _:b446363517 . _:b446361058 . _:b446362195 . _:b446363518 . _:b446363519 . _:b446363512 . _:b446361280 . _:b446363811 "2"^^ . _:b446363513 . _:b446362194 . _:b446363514 . _:b446363515 . _:b446363396 . _:b446361283 . _:b446363810 "2"^^ . _:b446363397 . _:b446361001 . _:b446362205 . _:b446363398 . _:b446363399 . . _:b446363392 . _:b446361282 . _:b446363821 "2"^^ . _:b446363393 . _:b446362204 . _:b446363394 . _:b446363395 . . _:b446363404 . . _:b446361293 . _:b446363820 "2"^^ . _:b446363405 . _:b446362207 . _:b446363406 . _:b446363407 . _:b446363400 . _:b446361292 . _:b446363823 "2"^^ . _:b446363401 . _:b446362206 . _:b446363402 . _:b446363403 . _:b446363412 . _:b446361295 . _:b446363822 "2"^^ . _:b446363413 . _:b446362201 . _:b446363414 . _:b446363415 . . . _:b446363408 . _:b446361294 . _:b446363817 "2"^^ . _:b446363409 . _:b446361110 . _:b446362200 . _:b446363410 . _:b446363411 . _:b446363420 . _:b446363323 . . _:b446361289 . _:b446363816 "2"^^ . _:b446363421 . _:b446362203 . . _:b446363422 . _:b446363423 . _:b446363416 . _:b446361288 . _:b446363819 "2"^^ . _:b446363417 . _:b446362202 . _:b446363418 . _:b446363419 . _:b446362222 . _:b446362292 . _:b446363428 . . _:b446363818 "2"^^ . _:b446363429 . _:b446361291 . _:b446362213 . _:b446363430 . _:b446363431 . _:b446363424 . _:b446361290 . _:b446364510 . _:b446363829 "2"^^ . _:b446363425 . _:b446362212 . _:b446363426 . _:b446363427 . . _:b446363436 . _:b446361301 . _:b446363828 "2"^^ . _:b446363437 . . . _:b446363438 . _:b446362215 . _:b446363439 . . _:b446363432 . _:b446360932 . _:b446363831 "2"^^ . _:b446363433 . . _:b446361300 . _:b446362214 . _:b446363434 . _:b446361368 . _:b446363435 . _:b446363444 . _:b446361303 . _:b446363830 "2"^^ . _:b446363445 . _:b446362209 . _:b446363446 . _:b446363447 . _:b446363440 . _:b446361302 . _:b446363825 "2"^^ . . _:b446363441 . . . _:b446363442 . _:b446362208 . _:b446363443 . _:b446363452 . _:b446361297 . _:b446363824 "2"^^ . _:b446363453 . _:b446362211 . . _:b446363454 . _:b446363455 . _:b446363448 . _:b446361296 . _:b446363827 "2"^^ . _:b446363449 . _:b446362210 . _:b446363450 . . _:b446363451 . . _:b446362820 . _:b446361299 . _:b446363826 "2"^^ . _:b446362821 . _:b446362221 . _:b446362822 . _:b446362823 . _:b446363239 . . _:b446362816 . _:b446361298 . _:b446363837 "2"^^ . _:b446362817 . _:b446362220 . _:b446362818 . . _:b446362819 . _:b446362828 . . _:b446361309 . _:b446363836 "2"^^ . _:b446361568 . _:b446362829 . _:b446362223 . _:b446362830 . _:b446362831 . _:b446362824 . _:b446361308 . _:b446363839 "2"^^ . _:b446361087 . _:b446362825 . _:b446362222 . _:b446362826 . _:b446362827 . _:b446361700 . _:b446362836 . . _:b446363838 "2"^^ . _:b446362837 . _:b446361311 . . _:b446362838 . _:b446362217 . _:b446362839 . _:b446362832 . _:b446361310 . _:b446363833 "2"^^ . _:b446363190 . _:b446362833 . _:b446362216 . _:b446362834 . _:b446362835 . . _:b446362844 . _:b446361305 . _:b446364530 . _:b446363832 "2"^^ . _:b446363076 . _:b446362845 . _:b446362219 . _:b446362838 . _:b446362846 . _:b446362847 . _:b446362840 . _:b446362309 . _:b446361304 . _:b446363835 "2"^^ . _:b446362841 . _:b446362218 . _:b446362842 . _:b446362843 . _:b446362852 . _:b446361307 . _:b446363834 "2"^^ . _:b446362853 . _:b446362229 . _:b446362854 . . _:b446362855 . . _:b446362848 . _:b446361306 . _:b446363845 "2"^^ . _:b446362849 . _:b446362228 . _:b446362850 . _:b446362189 . _:b446362851 . . _:b446362860 . _:b446361317 . _:b446363844 "2"^^ . _:b446362861 . _:b446362231 . _:b446362862 . _:b446362863 . . _:b446362856 . . _:b446361316 . _:b446363847 "2"^^ . _:b446362857 . _:b446362230 . _:b446362858 . . _:b446363948 . _:b446362859 . _:b446362868 . _:b446361319 . _:b446363846 "2"^^ . . _:b446362869 . _:b446362225 . _:b446362870 . _:b446362871 . _:b446362864 . _:b446361318 . _:b446363841 "2"^^ . _:b446362865 . _:b446362224 . _:b446362866 . _:b446362867 . _:b446362876 . _:b446363154 . _:b446361313 . _:b446363840 "2"^^ . _:b446363538 . _:b446362877 . _:b446362227 . _:b446363246 . _:b446362878 . _:b446362879 . _:b446362872 . _:b446361312 . _:b446363843 "2"^^ . _:b446362873 . _:b446362226 . _:b446362874 . _:b446362875 . _:b446363919 . _:b446362756 . _:b446361315 . _:b446363842 "2"^^ . _:b446362757 . _:b446362237 . _:b446362758 . . _:b446362759 . _:b446362752 . _:b446361314 . _:b446363853 "2"^^ . _:b446362753 . _:b446362236 . _:b446362754 . _:b446362755 . _:b446362764 . _:b446361325 . _:b446363852 "2"^^ . _:b446362765 . . _:b446362766 . _:b446362239 . _:b446362767 . _:b446363504 . _:b446362760 . _:b446361324 . _:b446363855 "2"^^ . _:b446362761 . _:b446362238 . _:b446362762 . _:b446362763 . _:b446361414 . _:b446362772 . _:b446361327 . _:b446363854 "2"^^ . _:b446362773 . _:b446362233 . _:b446362774 . _:b446360949 . _:b446362775 . _:b446362768 . _:b446361326 . _:b446363849 "2"^^ . _:b446362769 . _:b446362232 . _:b446362770 . _:b446362771 . _:b446362780 . _:b446362848 . _:b446361321 . _:b446363848 "2"^^ . _:b446362781 . _:b446362235 . _:b446362782 . _:b446362239 . _:b446362783 . _:b446362776 . _:b446361320 . _:b446363851 "2"^^ . _:b446362777 . . _:b446362778 . _:b446362234 . _:b446362779 . _:b446362788 . _:b446361323 . _:b446363850 "2"^^ . _:b446362789 . _:b446362245 . _:b446362790 . _:b446362791 . _:b446362784 . _:b446361322 . _:b446363861 "2"^^ . _:b446362785 . . _:b446362244 . _:b446362786 . _:b446362787 . _:b446362796 . _:b446362893 . _:b446361333 . _:b446363860 "2"^^ . _:b446362797 . _:b446362247 . _:b446362798 . _:b446362799 . . _:b446362792 . _:b446361332 . _:b446363863 "2"^^ . _:b446362793 . _:b446362246 . _:b446362794 . _:b446361883 . _:b446362795 . _:b446362804 . _:b446361335 . _:b446363862 "2"^^ . _:b446362805 . . _:b446362241 . _:b446363202 . _:b446362806 . _:b446362807 . . _:b446362800 . _:b446361334 . _:b446363857 "2"^^ . _:b446362801 . _:b446362240 . _:b446362802 . _:b446362803 . _:b446362812 . _:b446361329 . _:b446363856 "2"^^ . _:b446362813 . _:b446362243 . _:b446362814 . _:b446362815 . . _:b446362808 . _:b446361328 . _:b446363859 "2"^^ . _:b446362809 . _:b446362242 . _:b446362810 . _:b446362811 . _:b446362692 . . _:b446361331 . _:b446363858 "2"^^ . _:b446362693 . _:b446362253 . _:b446362694 . _:b446362695 . _:b446362688 . _:b446361330 . _:b446363869 "2"^^ . _:b446362689 . _:b446362252 . _:b446362690 . _:b446362691 . _:b446362700 . _:b446363690 . _:b446361341 . _:b446363868 "2"^^ . _:b446362701 . _:b446362255 . _:b446362702 . _:b446362703 . _:b446362696 . _:b446361340 . _:b446363871 "2"^^ . _:b446362697 . _:b446362254 . _:b9113979 . _:b446361548 . . _:b446362698 . _:b446362699 . _:b446362708 . _:b446361343 . _:b446363870 "2"^^ . _:b446362709 . _:b446362249 . _:b446362710 . _:b446362711 . _:b446362704 . _:b446361342 . _:b446363865 "2"^^ . _:b446362705 . _:b446362248 . _:b446362706 . _:b446362707 . _:b446362716 . _:b446361337 . _:b446363864 "2"^^ . _:b446362717 . _:b446362251 . _:b446362718 . _:b446362719 . _:b446362712 . _:b446361336 . _:b446363867 "2"^^ . _:b446362713 . _:b446362250 . _:b446362714 . _:b446362303 . _:b446362715 . _:b446362724 . _:b446361339 . _:b446363866 "2"^^ . _:b446362725 . _:b446362261 . _:b446362726 . _:b446362727 . _:b446362720 . _:b446361338 . _:b446363877 "2"^^ . _:b446362721 . _:b446362260 . _:b446362722 . _:b446362723 . _:b446360924 . _:b446362732 . _:b446362733 . _:b446363876 "2"^^ . _:b446362263 . . _:b446362734 . _:b446362735 . _:b446362728 . _:b446362729 . _:b446363879 "2"^^ . _:b446362262 . . _:b446362730 . . _:b446362731 . _:b446362740 . _:b446363862 . . _:b446363878 "2"^^ . _:b446362741 . _:b446360879 . _:b446362257 . _:b446362742 . _:b446362743 . _:b446362736 . _:b446362737 . _:b446363873 "2"^^ . _:b446362256 . _:b446362668 . _:b446362738 . _:b446362739 . _:b446362748 . _:b446362749 . _:b446363872 "2"^^ . _:b446362259 . _:b446362750 . . _:b446362362 . _:b446362751 . _:b446362744 . _:b446362745 . _:b446363875 "2"^^ . _:b446362258 . . _:b446362746 . _:b446362747 . _:b446362628 . _:b446364048 . _:b446362629 . _:b446363874 "2"^^ . _:b446362269 . _:b446362630 . _:b446362631 . . _:b446362624 . _:b446362625 . _:b446363885 "2"^^ . . _:b446362626 . _:b446362268 . . _:b446362627 . _:b446362636 . _:b446362637 . _:b446363884 "2"^^ . _:b446362271 . _:b446361532 . _:b446361308 . _:b446362638 . _:b446362639 . _:b446362632 . _:b446362633 . _:b446363887 "2"^^ . _:b446362270 . _:b446362634 . _:b446362635 . _:b446362780 . _:b446362644 . _:b446362645 . _:b446364406 . _:b446363886 "2"^^ . _:b446362265 . _:b446362646 . . _:b446362933 . _:b446362709 . _:b446362647 . _:b446362640 . _:b446362654 . _:b446361657 . _:b446363881 "2"^^ . _:b446362641 . _:b446362264 . _:b446362642 . _:b446362643 . _:b446364651 . _:b446362652 . _:b446361829 . _:b446363880 "2"^^ . _:b446363553 . _:b446362653 . _:b446362267 . _:b446364001 . _:b446362654 . _:b446362655 . . _:b446362648 . _:b446362649 . _:b446363883 "2"^^ . . _:b446362266 . _:b446362650 . _:b446362651 . _:b446363646 . _:b446362660 . . _:b446362661 . _:b446363882 "2"^^ . _:b446362277 . _:b446362662 . _:b446362663 . _:b446362656 . . _:b446362657 . _:b446363893 "2"^^ . _:b446361245 . _:b446362276 . _:b446362658 . _:b446362659 . _:b446362668 . _:b446360853 . _:b446363892 "2"^^ . _:b446362669 . _:b446362279 . _:b446362670 . _:b446360905 . _:b446362671 . _:b446363066 . _:b446362664 . _:b446360852 . _:b446363895 "2"^^ . _:b446362665 . . _:b446362278 . _:b446362666 . _:b446362667 . _:b446362676 . . _:b446363894 "2"^^ . _:b446362677 . _:b446360855 . _:b446362273 . _:b446362678 . . _:b446362679 . _:b446362672 . _:b446360854 . _:b446363889 "2"^^ . _:b446362673 . _:b446362272 . . _:b446362674 . _:b446362675 . _:b446362684 . _:b446364494 . _:b446360849 . _:b446363888 "2"^^ . _:b446362685 . _:b446362275 . _:b446363479 . _:b446362686 . _:b446362687 . _:b446362680 . _:b446362681 . _:b446363891 "2"^^ . _:b446362274 . _:b446362682 . _:b446362683 . _:b446363076 . _:b446360851 . _:b446363890 "2"^^ . _:b446363077 . _:b446362285 . _:b446363078 . _:b446363079 . _:b446363072 . _:b446360850 . _:b446363901 "2"^^ . _:b446363073 . _:b446362284 . _:b446363074 . _:b446363075 . _:b446363084 . _:b446360861 . _:b446363900 "2"^^ . _:b446363085 . _:b446362287 . _:b446363086 . . _:b446363087 . . _:b446363080 . _:b446360860 . _:b446363903 "2"^^ . _:b446362478 . _:b446363081 . _:b446362286 . _:b446363082 . . _:b446363083 . _:b446363092 . _:b446360863 . _:b446363902 "2"^^ . _:b446363093 . _:b446362281 . _:b446363094 . _:b446363095 . _:b446364524 . _:b446361785 . _:b446363088 . _:b446360862 . _:b446363897 "2"^^ . _:b446363089 . _:b446362280 . _:b446362733 . _:b446363090 . _:b446363091 . _:b446363100 . _:b446360857 . _:b446363896 "2"^^ . _:b446363101 . _:b446362283 . _:b446363102 . _:b446363103 . _:b446363096 . _:b446360856 . _:b446363899 "2"^^ . . _:b446363097 . _:b446362282 . _:b446363098 . _:b446363099 . _:b446363108 . . . _:b446363898 "2"^^ . _:b446363109 . _:b446360859 . . _:b446362293 . _:b446363110 . _:b446363111 . _:b446363104 . _:b446360858 . _:b446363909 "2"^^ . _:b446363105 . _:b446362292 . _:b446363106 . _:b446363107 . _:b446363116 . _:b446360869 . _:b446363908 "2"^^ . _:b446362659 . _:b446363117 . _:b446362295 . _:b446363118 . _:b446363119 . _:b446363112 . _:b446360868 . _:b446363911 "2"^^ . _:b446363113 . _:b446362294 . _:b446363114 . _:b446363115 . _:b446363124 . _:b446361906 . _:b446364287 . _:b446363910 "2"^^ . _:b446363125 . . _:b446360871 . _:b446362289 . _:b446363126 . _:b446363127 . _:b446363120 . . _:b446360870 . _:b446363905 "2"^^ . _:b446363121 . _:b446362288 . _:b446363122 . _:b446363123 . _:b446363132 . _:b446360865 . _:b446363904 "2"^^ . _:b446363133 . _:b446362291 . _:b446364289 . . _:b446363134 . _:b446363135 . _:b446363128 . _:b446360864 . _:b446363907 "2"^^ . _:b446363129 . _:b446362290 . _:b446363326 . _:b446363130 . _:b446363131 . _:b446363012 . _:b446360867 . _:b446363906 "2"^^ . _:b446361917 . _:b446363013 . _:b446362301 . _:b446363014 . _:b446363015 . _:b446363008 . _:b446360866 . _:b446363917 "2"^^ . _:b446363009 . _:b446362300 . _:b446363010 . _:b446363011 . _:b446364399 . _:b446363020 . . _:b446363916 "2"^^ . _:b446363021 . _:b446360877 . _:b446362303 . . _:b446363022 . _:b446363023 . _:b446363016 . _:b446361237 . _:b446363919 "2"^^ . _:b446363017 . _:b446360876 . _:b446362302 . _:b446363018 . _:b446363019 . _:b446363028 . _:b446360879 . _:b446363918 "2"^^ . _:b446363029 . _:b446362297 . _:b446363030 . _:b446363031 . _:b446363024 . _:b446360878 . _:b446363913 "2"^^ . _:b446363025 . _:b446362296 . _:b446363026 . _:b446363027 . _:b446363036 . _:b446361241 . _:b446364218 . _:b446363912 "2"^^ . _:b446363037 . _:b446360873 . _:b446362299 . _:b446363038 . _:b446363039 . _:b446363032 . _:b446360872 . _:b446363915 "2"^^ . _:b446363033 . _:b446362298 . _:b446363034 . _:b446363035 . _:b446361915 . _:b446363044 . _:b446360875 . _:b446363914 "2"^^ . _:b446363045 . _:b446363046 . _:b446362309 . _:b446363047 . _:b446363040 . _:b446360874 . _:b446363925 "2"^^ . _:b446363041 . _:b446362308 . _:b446363042 . . _:b446363043 . _:b446363110 . _:b446363052 . _:b446360885 . _:b446363924 "2"^^ . _:b446363053 . _:b446363054 . _:b446362311 . _:b446363055 . _:b446363048 . _:b446363998 . _:b446360884 . _:b446363947 . _:b446363927 "2"^^ . _:b446363049 . . _:b446362310 . _:b446363050 . _:b446363051 . _:b446363060 . _:b446360887 . _:b446363926 "2"^^ . _:b446363061 . _:b446362305 . _:b446363062 . _:b446363063 . _:b446363056 . _:b446360886 . _:b446363921 "2"^^ . _:b446363057 . _:b446361261 . _:b446362304 . _:b446363058 . _:b446363059 . . _:b446363068 . _:b446360881 . _:b446363920 "2"^^ . _:b446363069 . _:b446362307 . _:b446363070 . _:b446363071 . . _:b446363064 . _:b446360880 . _:b446363923 "2"^^ . _:b446363065 . _:b446362306 . _:b446363066 . _:b446363067 . _:b446362229 . . _:b446362948 . _:b446360883 . _:b446363922 "2"^^ . _:b446362949 . _:b446362950 . _:b446362317 . _:b446361476 . _:b446361040 . _:b446362951 . _:b446362944 . _:b446360882 . _:b446363933 "2"^^ . . _:b446362945 . . _:b446362316 . _:b446362946 . _:b446362947 . _:b446362956 . _:b446364107 . _:b446360893 . _:b446363932 "2"^^ . _:b446362957 . _:b446362958 . _:b446362319 . _:b446362959 . _:b446361467 . _:b446362952 . _:b446362203 . _:b446363935 "2"^^ . _:b446362953 . _:b446360892 . _:b446362954 . _:b446362318 . _:b446362955 . _:b446363886 . . _:b446362964 . _:b446361550 . _:b446360895 . _:b446363934 "2"^^ . _:b446362965 . _:b446362966 . _:b446362313 . . . _:b446362967 . _:b446362960 . _:b446360894 . _:b446363929 "2"^^ . _:b446362961 . _:b446362962 . _:b446362312 . _:b446362963 . _:b446362972 . _:b446360889 . _:b446363928 "2"^^ . _:b446362973 . _:b446362974 . _:b446362315 . _:b446362975 . _:b446362968 . _:b446360888 . _:b446363931 "2"^^ . _:b446362969 . _:b446362970 . _:b446362314 . _:b446362971 . _:b446362980 . . _:b446363930 "2"^^ . _:b446362981 . _:b446360891 . _:b446362982 . _:b446363865 . _:b446362325 . _:b446362983 . _:b446362976 . _:b446360890 . _:b446363941 "2"^^ . _:b446362977 . _:b446361954 . _:b446362324 . _:b446362978 . _:b446362979 . _:b446362988 . _:b446360901 . _:b446363940 "2"^^ . _:b446362989 . . _:b446362327 . _:b446362990 . _:b446362991 . _:b446361388 . _:b446362984 . _:b446360900 . _:b446363943 "2"^^ . _:b446362985 . _:b446362986 . _:b446362326 . . _:b446360902 . _:b446362987 . _:b446362996 . _:b446360903 . _:b446363942 "2"^^ . _:b446362997 . . _:b446362998 . _:b446362321 . _:b446362999 . _:b446362992 . _:b446360902 . _:b446363937 "2"^^ . _:b446362993 . _:b446362994 . _:b446364526 . _:b446363697 . _:b446363548 . _:b446362320 . _:b446362995 . _:b446363004 . _:b446360897 . _:b446363936 "2"^^ . . _:b446363005 . _:b446363006 . _:b446362323 . _:b446363007 . _:b446361530 . _:b446363000 . _:b446360896 . _:b446363939 "2"^^ . _:b446363001 . _:b446363002 . _:b446364389 . _:b446362322 . . _:b446363003 . _:b446362884 . _:b446360899 . _:b446363938 "2"^^ . _:b446362885 . _:b446362886 . _:b446362333 . _:b446362887 . _:b446362880 . _:b446360898 . _:b446363949 "2"^^ . _:b446362881 . _:b446362882 . _:b446362332 . _:b446362883 . _:b446363186 . _:b446362892 . _:b446360909 . _:b446363948 "2"^^ . _:b446362893 . . _:b446362335 . _:b446362894 . _:b446362895 . _:b446362888 . _:b446360908 . _:b446363951 "2"^^ . _:b446362889 . _:b446362890 . _:b446362334 . _:b446362891 . _:b446362900 . _:b446360911 . _:b446363950 "2"^^ . _:b446362901 . . _:b446362329 . . _:b446362902 . _:b446362903 . _:b446362896 . _:b446360910 . _:b446363945 "2"^^ . _:b446362897 . . _:b446362328 . _:b446362898 . _:b446362899 . _:b446362908 . _:b446360905 . _:b446363944 "2"^^ . _:b446362909 . _:b446362910 . _:b446362331 . _:b446362911 . _:b446361622 . . _:b446361411 . _:b446362904 . _:b446360904 . _:b446363947 "2"^^ . _:b446362905 . _:b446362906 . _:b446362330 . _:b446362907 . _:b446362916 . _:b446360907 . _:b446363946 "2"^^ . _:b446362917 . . _:b446362341 . _:b446362918 . _:b446362919 . _:b446362912 . _:b446360906 . _:b446363957 "2"^^ . _:b446362913 . _:b446362914 . _:b446362340 . _:b446362915 . _:b446362924 . _:b446360917 . _:b446363956 "2"^^ . _:b446362925 . _:b446362926 . _:b446362343 . _:b446362927 . . _:b446362920 . _:b446360916 . _:b446363959 "2"^^ . _:b446362483 . _:b446362921 . _:b446362922 . _:b446362342 . _:b446362923 . _:b446362932 . _:b446360919 . _:b446363958 "2"^^ . _:b446362933 . _:b446362934 . _:b446362337 . _:b446361400 . _:b446362935 . . _:b446362928 . _:b446360918 . _:b446363953 "2"^^ . _:b446362929 . _:b446361574 . _:b446362336 . _:b446362930 . _:b446362931 . _:b446362940 . _:b446360913 . _:b446363952 "2"^^ . _:b446362941 . . _:b446362942 . _:b446362339 . . _:b446362943 . _:b446362936 . _:b446363786 . _:b446360912 . _:b446364556 . _:b446363955 "2"^^ . _:b446362937 . _:b446362938 . _:b446362338 . _:b446362939 . _:b446362308 . _:b446360915 . _:b446363954 "2"^^ . _:b446362309 . _:b446362310 . _:b446362349 . _:b446362311 . _:b446362304 . _:b446364326 . _:b446360914 . _:b446363965 "2"^^ . _:b446362523 . . _:b446362305 . _:b446362306 . _:b446362348 . _:b446362307 . _:b446362913 . _:b446362316 . _:b446362153 . _:b446363964 "2"^^ . _:b446362317 . _:b446360925 . _:b446362318 . _:b446362351 . _:b446362319 . _:b446362312 . _:b446360924 . _:b446363967 "2"^^ . _:b446362313 . _:b446362314 . _:b446362350 . . _:b446362315 . . _:b446362324 . _:b446360927 . _:b446363966 "2"^^ . _:b446362325 . _:b446362326 . _:b446362345 . _:b446362327 . . _:b446362320 . _:b446360926 . _:b446363961 "2"^^ . _:b446362667 . _:b446362321 . _:b446362322 . _:b446362344 . _:b446362323 . _:b446362332 . _:b446360921 . _:b446363960 "2"^^ . _:b446362333 . _:b446362334 . _:b446362347 . _:b446362335 . _:b446362328 . _:b446360920 . _:b446363963 "2"^^ . _:b446362329 . _:b446362330 . _:b446362346 . _:b446360976 . _:b446362331 . _:b446362340 . _:b446360923 . _:b446363962 "2"^^ . _:b446362341 . _:b446362342 . _:b446362357 . . _:b446362343 . _:b446362129 . _:b446362407 . _:b446362336 . _:b446360922 . _:b446363973 "2"^^ . _:b446362337 . _:b446362338 . _:b446362356 . _:b446362339 . _:b446362348 . _:b446363599 . _:b446360933 . _:b446363972 "2"^^ . _:b446362349 . . _:b446362359 . _:b446361985 . _:b446362350 . . _:b446362351 . _:b446363590 . . _:b446362344 . . _:b446363975 "2"^^ . _:b446362345 . _:b446360932 . _:b446362346 . _:b446362358 . _:b446362347 . _:b446362356 . _:b446364228 . _:b446360935 . _:b446363974 "2"^^ . _:b446362357 . _:b446362358 . _:b446362857 . _:b446362353 . _:b446362359 . . _:b446362352 . _:b446360934 . _:b446363969 "2"^^ . _:b446362353 . _:b446362354 . _:b446362352 . _:b446362355 . _:b446363095 . . _:b446362364 . . _:b446363968 "2"^^ . . _:b446362365 . _:b446360929 . _:b446361599 . _:b446362355 . . _:b446362366 . _:b446362367 . . _:b446363987 . _:b446362360 . _:b446360928 . _:b446363971 "2"^^ . _:b446362361 . _:b446362362 . _:b446362354 . _:b446362363 . _:b446361231 . _:b446362244 . _:b446360931 . _:b446363970 "2"^^ . _:b446362245 . _:b446361939 . _:b446362365 . _:b446362246 . _:b446362247 . _:b446362240 . _:b446363819 . _:b446360930 . _:b446363981 "2"^^ . _:b446362241 . _:b446362242 . _:b446362364 . . _:b446362243 . _:b446362252 . . _:b446360941 . _:b446363980 "2"^^ . _:b446363911 . _:b446362253 . _:b446362254 . _:b446362367 . _:b446362255 . _:b446360964 . _:b446362248 . _:b446360940 . _:b446363983 "2"^^ . _:b446362249 . _:b446362250 . _:b446362505 . _:b446362366 . _:b446362251 . _:b446362260 . _:b446360943 . _:b446363982 "2"^^ . _:b446362261 . _:b446362262 . _:b446362361 . _:b446362263 . . _:b446362256 . _:b446360942 . _:b446363977 "2"^^ . _:b446362257 . _:b446362258 . _:b446364641 . _:b446362360 . _:b446361893 . _:b446362259 . _:b446362268 . _:b446360937 . _:b446363976 "2"^^ . _:b446362356 . _:b446362269 . _:b446362270 . _:b446362363 . _:b446362271 . _:b446361864 . _:b446362264 . _:b446362867 . _:b446360936 . _:b446363979 "2"^^ . _:b446362265 . _:b446362266 . _:b446362362 . _:b446362267 . _:b446362276 . . _:b446360939 . _:b446363978 "2"^^ . _:b446362425 . _:b446362277 . _:b446361861 . _:b446360968 . _:b446362278 . _:b446362279 . _:b446362272 . _:b446360938 . _:b446363989 "2"^^ . _:b446362273 . _:b446361860 . _:b446362274 . _:b446362275 . . . _:b446362284 . _:b446360949 . _:b446363988 "2"^^ . _:b446362285 . _:b446361863 . _:b446362286 . _:b446362287 . _:b446362280 . _:b446360948 . _:b446363991 "2"^^ . _:b446362281 . _:b446361862 . _:b446362282 . _:b446362283 . . _:b446362292 . _:b446360951 . _:b446363990 "2"^^ . _:b446362293 . _:b446361857 . _:b446361256 . _:b446362294 . _:b446362295 . _:b446362288 . _:b446360950 . _:b446363985 "2"^^ . _:b446362289 . _:b446361856 . _:b446362290 . _:b446362291 . _:b446362300 . _:b446360945 . _:b446363984 "2"^^ . _:b446362301 . . _:b446362302 . _:b446361859 . _:b446362303 . _:b446362296 . _:b446364091 . . _:b446363987 "2"^^ . _:b446363562 . _:b446362297 . _:b446361053 . _:b446360944 . . _:b446362298 . _:b446361858 . _:b446362299 . _:b446362180 . _:b446360947 . _:b446363986 "2"^^ . _:b446362181 . _:b446361869 . _:b446362182 . _:b446361724 . _:b446362183 . _:b446362365 . _:b446362176 . _:b446360946 . _:b446363997 "2"^^ . _:b446362177 . _:b446361868 . _:b446363879 . _:b446362076 . _:b446362178 . _:b446362179 . _:b446362188 . _:b446360957 . _:b446363996 "2"^^ . _:b446362189 . _:b446361871 . _:b446363127 . _:b446362988 . _:b446362190 . _:b446362191 . . _:b446362184 . _:b446360956 . _:b446363999 "2"^^ . _:b446362185 . _:b446361870 . _:b446362186 . _:b446361573 . . _:b446362187 . _:b446362196 . _:b446360959 . _:b446363998 "2"^^ . _:b446362197 . _:b446361865 . _:b446362198 . _:b446362199 . _:b446362192 . _:b446360958 . _:b446364328 . _:b446363993 "2"^^ . _:b446362193 . _:b446361864 . . _:b446362194 . _:b446362195 . _:b446362204 . _:b446361806 . _:b446363992 "2"^^ . _:b446362205 . _:b446360953 . _:b446361867 . _:b446362206 . _:b446362207 . . _:b446362650 . _:b446362200 . _:b446360952 . _:b446363995 "2"^^ . _:b446362201 . _:b446361866 . _:b446362202 . _:b446362203 . _:b446362212 . _:b446360955 . _:b446363994 "2"^^ . _:b446362213 . . _:b446361877 . _:b446362214 . . . _:b446362215 . . _:b446362208 . _:b446360954 . _:b446364005 "2"^^ . _:b446362209 . _:b446361876 . _:b446362210 . _:b446360959 . _:b446362211 . _:b446362220 . _:b446360965 . _:b446364004 "2"^^ . _:b446362221 . _:b446361879 . _:b446362222 . _:b446362223 . _:b446364559 . _:b446362216 . _:b446360964 . _:b446364007 "2"^^ . _:b446360974 . _:b446362217 . _:b446361878 . _:b446362218 . _:b446362219 . _:b446362228 . _:b446362413 . . _:b446364006 "2"^^ . _:b446362229 . _:b446360967 . . _:b446362230 . _:b446361873 . _:b446362231 . _:b446362485 . _:b446362224 . _:b446360966 . _:b446364001 "2"^^ . _:b446362225 . . _:b446361872 . _:b446363398 . _:b446362226 . _:b446362227 . . _:b446362236 . _:b446360961 . _:b446364000 "2"^^ . _:b446362237 . _:b446361875 . _:b446362238 . . _:b446362239 . _:b446362232 . _:b446361968 . _:b446364003 "2"^^ . _:b446362233 . _:b446360960 . _:b446361874 . _:b446362234 . _:b446362235 . _:b446362116 . _:b446360963 . _:b446364002 "2"^^ . _:b446362117 . . _:b446362118 . _:b446361885 . _:b446362119 . _:b446360867 . _:b446362112 . . _:b446364013 "2"^^ . _:b446362113 . _:b446360962 . _:b446361884 . _:b446362114 . . _:b446362115 . _:b446362124 . _:b446360973 . _:b446364012 "2"^^ . _:b446362125 . _:b446361887 . _:b446362126 . . _:b446362127 . _:b446362120 . _:b446360972 . _:b446364015 "2"^^ . . _:b446362121 . _:b446361886 . _:b446362122 . _:b446362123 . _:b446362132 . _:b446360975 . _:b446364014 "2"^^ . _:b446362133 . _:b446361881 . _:b446364453 . _:b446362134 . _:b446362135 . _:b446362128 . _:b446360974 . _:b446364009 "2"^^ . _:b446362129 . _:b446361880 . _:b446362130 . _:b446362131 . _:b446362301 . _:b446362140 . _:b446360969 . _:b446364008 "2"^^ . _:b446362141 . _:b446361883 . _:b446362142 . _:b446362143 . _:b446362136 . . _:b446364011 "2"^^ . _:b446362137 . _:b446360968 . _:b446361882 . _:b446362138 . . _:b446362914 . _:b446360861 "35"^^ . _:b446362139 . _:b446362148 . _:b446364130 . _:b446360971 . _:b446364010 "2"^^ . _:b446362149 . _:b446361893 . _:b446362150 . _:b446362151 . _:b446362144 . _:b446360860 "36"^^ . _:b446361156 . _:b446364021 "2"^^ . _:b446362145 . _:b446360970 . _:b446361892 . _:b446362146 . . _:b446360863 "35"^^ . . _:b446362147 . _:b446361551 . _:b446362156 . _:b446360981 . _:b446364020 "2"^^ . _:b446360852 "73"^^ . _:b446362157 . _:b446361895 . _:b446362158 . _:b446362159 . _:b446360862 "35"^^ . _:b446362152 . . _:b446364023 "2"^^ . . _:b446362153 . _:b446360980 . _:b446361894 . _:b446362154 . _:b446362155 . _:b446360858 "39"^^ . _:b446362261 . . _:b446360851 "76"^^ . _:b446362164 . _:b446360983 . _:b446364022 "2"^^ . _:b446362165 . . _:b446361889 . _:b446362166 . _:b446362167 . _:b446362160 . _:b446360982 . _:b446364017 "2"^^ . _:b446362161 . _:b446361888 . _:b446363511 . _:b446362162 . . _:b446360857 "43"^^ . _:b446362163 . . _:b446360859 "36"^^ . _:b446362172 . _:b446360977 . _:b446364016 "2"^^ . _:b446362173 . _:b446361891 . _:b446362174 . _:b446362175 . . _:b446360856 "43"^^ . _:b446362168 . _:b446360976 . _:b446364019 "2"^^ . _:b446362169 . _:b446361890 . _:b446362170 . _:b446362171 . . _:b446362564 . _:b446360979 . _:b446364018 "2"^^ . _:b446360855 "45"^^ . _:b446362565 . . _:b446361901 . _:b446362566 . _:b446362567 . _:b446362560 . _:b446360978 . _:b446364029 "2"^^ . _:b446362561 . _:b446361900 . _:b446362562 . . . _:b446362563 . _:b446362572 . _:b446360989 . _:b446364180 . _:b446364028 "2"^^ . _:b446362573 . _:b446361903 . _:b446362973 . _:b446362574 . . _:b446362575 . _:b446364015 . _:b446362568 . _:b446360988 . _:b446364031 "2"^^ . _:b446362569 . _:b446361902 . _:b446360853 "50"^^ . _:b446361851 . _:b446362570 . _:b446362571 . . _:b446362580 . _:b446360991 . _:b446364030 "2"^^ . _:b446362581 . _:b446361897 . . _:b446362582 . _:b446362583 . _:b446361879 . _:b446362576 . _:b446360990 . _:b446364025 "2"^^ . _:b446362577 . _:b446361896 . _:b446362946 . _:b446362578 . _:b446362579 . _:b446360854 "47"^^ . _:b446362588 . _:b446362386 . _:b446360985 . _:b446364024 "2"^^ . _:b446362589 . _:b446361015 . _:b446362590 . _:b446361899 . _:b446362591 . _:b446362584 . _:b446360984 . _:b446364027 "2"^^ . _:b446362585 . _:b446361898 . _:b446362586 . _:b446362587 . _:b446362596 . _:b446360987 . _:b446364026 "2"^^ . _:b446362597 . _:b446361909 . _:b446362598 . _:b446362599 . _:b446362592 . _:b446360986 . _:b446364037 "2"^^ . _:b446362593 . _:b446360915 . _:b446361908 . _:b446362594 . _:b446362595 . . . _:b446362604 . _:b446360997 . _:b446364036 "2"^^ . _:b446362605 . _:b446361911 . _:b446362606 . _:b446362607 . _:b446362600 . _:b446362844 . _:b446360996 . _:b446364039 "2"^^ . _:b446362601 . . _:b446361910 . _:b446363585 . _:b446362602 . _:b446362603 . _:b446362612 . _:b446360999 . _:b446364038 "2"^^ . _:b446362613 . _:b446361905 . _:b446363618 . _:b446362614 . . _:b446362615 . . _:b446362608 . _:b446362171 . _:b446364033 "2"^^ . _:b446362609 . _:b446361704 . _:b446360998 . _:b446361904 . _:b446362610 . _:b446362611 . . _:b446362620 . . _:b446360993 . _:b446364032 "2"^^ . _:b446362621 . _:b446361907 . _:b446364525 . _:b446362622 . _:b446362623 . _:b446362616 . _:b446360992 . _:b446364035 "2"^^ . _:b446362617 . _:b446361906 . _:b446362618 . _:b446361367 . _:b446362619 . _:b446362500 . _:b446362263 . _:b446364034 "2"^^ . _:b446362501 . _:b446360995 . . _:b446361917 . _:b446364503 . _:b446362502 . _:b446362503 . _:b446362496 . _:b446360994 . _:b446364045 "2"^^ . . _:b446362497 . _:b446361916 . _:b446362498 . _:b446362499 . _:b446362508 . _:b446361005 . _:b446364044 "2"^^ . _:b446362509 . _:b446361919 . _:b446362510 . _:b446362511 . _:b446362504 . _:b446361004 . _:b446364047 "2"^^ . _:b446362505 . _:b446361918 . _:b446362506 . _:b446362507 . _:b446362516 . _:b446361007 . _:b446364046 "2"^^ . _:b446362271 . _:b446362517 . . _:b446361913 . _:b446362159 . _:b446362518 . _:b446362519 . _:b446362512 . _:b446360990 . _:b446364041 "2"^^ . _:b446362513 . _:b446361006 . _:b446361912 . _:b446362514 . _:b446362515 . _:b446362524 . _:b446362344 . _:b446361001 . _:b446364040 "2"^^ . _:b446362525 . _:b446361915 . _:b446362526 . _:b446361521 . _:b446363989 . _:b446362954 . _:b446362527 . _:b446361107 . _:b446363783 . _:b446362520 . _:b446361000 . _:b446364043 "2"^^ . _:b446362521 . _:b446361914 . _:b446362522 . _:b446362523 . _:b446361023 . _:b446362532 . . _:b446364042 "2"^^ . _:b446362533 . _:b446361003 . _:b446361925 . _:b446362534 . _:b446362535 . . _:b446362528 . _:b446361002 . _:b446364053 "2"^^ . _:b446362529 . _:b446361924 . _:b446362530 . _:b446362531 . _:b446361315 . _:b446362540 . _:b446361013 . _:b446364052 "2"^^ . _:b446362541 . _:b446361927 . _:b446362542 . _:b446362543 . . _:b446362536 . _:b446361012 . _:b446364055 "2"^^ . _:b446362537 . _:b446361926 . _:b446362538 . _:b446362061 . _:b446362539 . _:b446362548 . _:b446360871 "28"^^ . _:b446361015 . _:b446364054 "2"^^ . _:b446362549 . _:b446361921 . _:b446362550 . . _:b446362551 . _:b446362544 . _:b446361014 . _:b446364049 "2"^^ . _:b446360870 "29"^^ . _:b446362545 . _:b446361920 . _:b446362546 . _:b446362547 . _:b446362556 . . _:b446364048 "2"^^ . _:b446362557 . _:b446361009 . _:b446361923 . _:b446362558 . _:b446362267 . _:b446362559 . _:b446362552 . _:b446361008 . _:b446364051 "2"^^ . _:b446362553 . _:b446361922 . _:b446360875 "26"^^ . _:b446362554 . _:b446361835 . _:b446362555 . . . _:b446362436 . _:b446361011 . _:b446364050 "2"^^ . _:b446362437 . . _:b446361933 . _:b446362438 . _:b446362439 . _:b446360874 "27"^^ . _:b446361474 . _:b446362432 . _:b446362191 . _:b446361010 . _:b446364061 "2"^^ . _:b446362433 . . _:b446362434 . _:b446361932 . _:b446362435 . _:b446360873 "27"^^ . _:b446362444 . _:b446362540 . _:b446361021 . _:b446364060 "2"^^ . _:b446362445 . _:b446361935 . _:b446362446 . _:b446361293 . _:b446362936 . _:b446360872 "27"^^ . _:b446362447 . . _:b446362440 . _:b446361020 . _:b446364063 "2"^^ . _:b446362441 . . _:b446362442 . _:b446361934 . _:b446362443 . . _:b446362452 . _:b446361023 . _:b446364062 "2"^^ . _:b446362522 . _:b446360878 "25"^^ . _:b446362453 . _:b446361929 . _:b446362454 . _:b446362455 . _:b446362448 . _:b446361022 . _:b446364057 "2"^^ . _:b446362402 . _:b446360879 "25"^^ . _:b446362449 . _:b446361928 . _:b446362450 . _:b446362451 . _:b446362460 . _:b446361017 . _:b446364056 "2"^^ . _:b446362461 . _:b446361931 . _:b446360876 "26"^^ . _:b446362462 . _:b446362463 . _:b446362456 . _:b446364258 . _:b446361016 . _:b446364059 "2"^^ . _:b446360877 "25"^^ . _:b446362457 . _:b446361930 . _:b446362458 . _:b446362459 . _:b446362468 . _:b446360882 "24"^^ . _:b446361019 . _:b446364058 "2"^^ . _:b446362469 . _:b446361941 . _:b446362470 . _:b446362471 . _:b446362464 . _:b446360883 "24"^^ . . _:b446361018 . _:b446364069 "2"^^ . _:b446363143 . _:b446362465 . _:b446361940 . _:b446362466 . _:b446362467 . _:b446362476 . _:b446361029 . _:b446364068 "2"^^ . _:b446360880 "25"^^ . _:b446362477 . _:b446361943 . _:b446364447 . _:b446362478 . _:b446362479 . _:b446362472 . . _:b446361028 . _:b446364071 "2"^^ . _:b446360881 "25"^^ . _:b446362473 . _:b446361942 . _:b446362568 . _:b446362474 . _:b446362475 . _:b446360886 "23"^^ . _:b446362484 . . _:b446361031 . _:b446364070 "2"^^ . _:b446362485 . _:b446361937 . _:b446362486 . _:b446362487 . _:b446360887 "23"^^ . _:b446362480 . _:b446361030 . _:b446364065 "2"^^ . _:b446362481 . . _:b446361936 . _:b446362482 . _:b446362483 . _:b446362492 . _:b446360884 "24"^^ . _:b446361373 . _:b446361025 . _:b446364064 "2"^^ . _:b446363564 . _:b446362493 . _:b446361939 . _:b446362494 . _:b446362495 . _:b446362907 . _:b446360885 "23"^^ . _:b446362488 . . _:b446361024 . _:b446364067 "2"^^ . _:b446362489 . _:b446361938 . _:b446360890 "22"^^ . _:b446362490 . _:b446362491 . _:b446360868 "31"^^ . . _:b446362372 . _:b446361027 . _:b446364066 "2"^^ . _:b446362373 . _:b446361949 . _:b446360869 "30"^^ . _:b446360891 "22"^^ . _:b446360849 "110"^^ . _:b446362374 . _:b446362375 . _:b446363795 . . _:b446362368 . _:b446361026 . _:b446364077 "2"^^ . _:b446362369 . _:b446361948 . _:b446362370 . . _:b446362371 . _:b446360888 "23"^^ . _:b446362380 . _:b446361037 . _:b446364076 "2"^^ . _:b446362381 . _:b446361951 . . _:b446362382 . _:b446362383 . _:b446360889 "23"^^ . _:b446362376 . _:b446361036 . _:b446364079 "2"^^ . _:b446362377 . _:b446361950 . . _:b446362378 . _:b446362379 . _:b446362388 . _:b446362923 . _:b446362847 . _:b446361039 . _:b446364078 "2"^^ . _:b446360893 "21"^^ . _:b446362389 . _:b446361945 . _:b446363192 . _:b446362390 . _:b446362391 . _:b446360864 "35"^^ . _:b446360865 "31"^^ . _:b446360850 "107"^^ . _:b446362384 . _:b446361038 . _:b446364073 "2"^^ . _:b446360892 "21"^^ . _:b446362385 . _:b446361944 . _:b446362386 . _:b446362387 . . _:b446360866 "31"^^ . _:b446362396 . _:b446361033 . _:b446364072 "2"^^ . _:b446360895 "21"^^ . _:b446362397 . _:b446361947 . _:b446362398 . _:b446362399 . _:b446360867 "31"^^ . _:b446362392 . _:b446361032 . _:b446364075 "2"^^ . _:b446360894 "21"^^ . _:b446362393 . _:b446361946 . _:b446362566 . _:b446362394 . _:b446362395 . _:b446362404 . _:b446360897 "20"^^ . _:b446361035 . _:b446364074 "2"^^ . _:b446362405 . _:b446361830 . _:b446364373 . _:b446362406 . _:b446361957 . _:b446362407 . _:b446362400 . _:b446361517 . _:b446364085 "2"^^ . _:b446360896 "21"^^ . _:b446362401 . _:b446361034 . _:b446361583 . _:b446362402 . _:b446361956 . _:b446362403 . _:b446360899 "19"^^ . _:b446362412 . _:b446361045 . _:b446364084 "2"^^ . _:b446362413 . _:b446361959 . _:b446362414 . _:b446362415 . . _:b446360898 "20"^^ . _:b446362408 . . . _:b446364087 "2"^^ . _:b446362409 . _:b446361044 . _:b446361958 . _:b446362410 . . _:b446362411 . _:b446360901 "19"^^ . . _:b446362420 . _:b446361047 . _:b446364086 "2"^^ . _:b446362421 . _:b446361953 . _:b446362422 . . _:b446360900 "19"^^ . _:b446362423 . _:b446362416 . _:b446361186 . _:b446361046 . _:b446364081 "2"^^ . _:b446362417 . _:b446361952 . _:b446362418 . _:b446362419 . _:b446360903 "19"^^ . _:b446362428 . _:b446361041 . _:b446364080 "2"^^ . _:b446362429 . _:b446361955 . _:b446362430 . _:b446362431 . _:b446360902 "19"^^ . _:b446362041 . _:b446362424 . _:b446361040 . _:b446364083 "2"^^ . _:b446363029 . _:b446362425 . _:b446361954 . _:b446360905 "18"^^ . _:b446362426 . _:b446362427 . _:b446361796 . _:b446361043 . _:b446364082 "2"^^ . _:b446361797 . _:b446361965 . _:b446362461 . _:b446360904 "18"^^ . _:b446361798 . . . . _:b446361799 . _:b446361792 . _:b446361042 . _:b446364093 "2"^^ . _:b446361793 . _:b446361480 . _:b446360907 "18"^^ . _:b446361794 . _:b446361964 . . _:b446363852 . _:b446361795 . . _:b446361804 . _:b446361053 . _:b446364092 "2"^^ . _:b446361805 . _:b446361967 . _:b446360906 "18"^^ . _:b446361806 . _:b446361807 . _:b446361800 . _:b446361052 . _:b446364095 "2"^^ . _:b446364063 . _:b446363966 . _:b446361801 . _:b446361966 . _:b446360909 "18"^^ . _:b446361802 . _:b446361803 . . _:b446361812 . _:b446361055 . _:b446364094 "2"^^ . _:b446361813 . _:b446361961 . _:b446360908 "18"^^ . _:b446361814 . _:b446361815 . _:b446361808 . _:b446361054 . _:b446364089 "2"^^ . _:b446361809 . _:b446361960 . . _:b446361810 . _:b446361811 . _:b446361820 . _:b446361049 . _:b446364088 "2"^^ . _:b446361821 . _:b446361963 . _:b446360910 "18"^^ . _:b446361822 . _:b446361823 . _:b446361816 . _:b446361048 . _:b446364091 "2"^^ . _:b446360911 "17"^^ . _:b446361817 . _:b446361962 . _:b446364662 . _:b446361818 . _:b446362220 . _:b446361819 . _:b446361828 . _:b446361051 . _:b446364090 "2"^^ . _:b446360912 "17"^^ . _:b446361829 . _:b446361973 . _:b446361830 . _:b446361831 . . _:b446361824 . _:b446361050 . _:b446364101 "2"^^ . _:b446360913 "17"^^ . _:b446361825 . _:b446361972 . _:b446361826 . _:b446361827 . . _:b446361836 . _:b446361061 . _:b446364100 "2"^^ . _:b446360914 "17"^^ . _:b446361837 . _:b446361975 . _:b446361376 . _:b446361838 . _:b446361839 . _:b446361832 . _:b446363337 . _:b446360915 "16"^^ . . _:b446364103 "2"^^ . _:b446361833 . _:b446361060 . _:b446361974 . _:b446361834 . _:b446361835 . _:b446361844 . _:b446360916 "16"^^ . . _:b446364102 "2"^^ . _:b446361845 . _:b446361063 . _:b446361969 . _:b446361846 . . _:b446362448 . _:b446361847 . _:b446360908 . _:b446360917 "16"^^ . _:b446361840 . . _:b446361062 . _:b446364097 "2"^^ . _:b446361841 . . _:b446362721 . _:b446361842 . _:b446361968 . _:b446361843 . _:b446361852 . _:b446360918 "16"^^ . _:b446361057 . _:b446364096 "2"^^ . _:b446361853 . _:b446361971 . _:b446361854 . _:b446361855 . _:b446361848 . _:b446360919 "16"^^ . _:b446361056 . _:b446364099 "2"^^ . _:b446361918 . _:b446361849 . _:b446361970 . _:b446361850 . _:b446361851 . _:b446361732 . _:b446360920 "16"^^ . _:b446361059 . _:b446364098 "2"^^ . _:b446361733 . _:b446361981 . _:b446361734 . _:b446361735 . _:b446362883 . _:b446361728 . _:b446362623 . _:b446360921 "16"^^ . _:b446361058 . _:b446364109 "2"^^ . _:b446361729 . _:b446361980 . _:b446361730 . _:b446361731 . . _:b446360922 "16"^^ . _:b446361740 . _:b446361069 . _:b446364108 "2"^^ . _:b446363715 . _:b446361741 . _:b446361983 . _:b446361742 . _:b446361743 . _:b446362868 . _:b446361115 . _:b446360923 "16"^^ . _:b446361736 . _:b446361068 . _:b446364111 "2"^^ . _:b446361737 . _:b446361982 . _:b446361738 . _:b446361739 . _:b446361748 . _:b446360924 "16"^^ . _:b446361071 . _:b446364110 "2"^^ . _:b446361749 . _:b446361207 . _:b446361977 . _:b446361750 . . _:b446361751 . _:b446361744 . _:b446360925 "16"^^ . . _:b446361070 . _:b446364105 "2"^^ . _:b446361745 . _:b446361184 . _:b446361746 . _:b446361976 . _:b446361111 . _:b446361747 . . _:b446360926 "16"^^ . _:b446361756 . _:b446361065 . _:b446364104 "2"^^ . _:b446361757 . . _:b446361979 . _:b446361758 . _:b446361759 . _:b446362730 . . _:b446360927 "16"^^ . . _:b446361752 . _:b446361064 . _:b446364107 "2"^^ . _:b446361753 . _:b446361978 . _:b446361754 . _:b446361755 . _:b446360928 "15"^^ . _:b446361764 . _:b446361067 . _:b446364106 "2"^^ . _:b446361765 . _:b446361989 . _:b446361766 . _:b446361766 . _:b446360929 "15"^^ . _:b446361767 . _:b446361760 . _:b446361066 . _:b446364117 "2"^^ . _:b446361761 . _:b446361988 . _:b446361762 . . . _:b446360930 "15"^^ . _:b446361763 . _:b446361732 . _:b446361772 . _:b446361077 . _:b446364116 "2"^^ . _:b446361773 . _:b446361991 . _:b446360956 . _:b446361774 . _:b446361775 . _:b446360931 "15"^^ . . _:b446361768 . _:b446361076 . _:b446364119 "2"^^ . _:b446361769 . _:b446361990 . _:b446361770 . _:b446361771 . _:b446364241 . _:b446360932 "15"^^ . _:b446361780 . _:b446361628 . _:b446361079 . _:b446364118 "2"^^ . _:b446361781 . _:b446361985 . _:b446361782 . _:b446361783 . . _:b446360933 "15"^^ . _:b446361776 . _:b446364490 . _:b446361078 . _:b446364113 "2"^^ . _:b446361777 . _:b446361984 . _:b446361778 . _:b446361779 . _:b446360934 "15"^^ . _:b446361788 . _:b446361073 . _:b446364112 "2"^^ . _:b446361789 . _:b446361987 . _:b446361790 . _:b446361791 . _:b446360935 "15"^^ . _:b446361784 . _:b446361072 . _:b446364115 "2"^^ . _:b446361785 . _:b446361986 . _:b446361786 . _:b446361787 . _:b446363901 . _:b446360936 "15"^^ . _:b446361668 . _:b446361075 . _:b446364114 "2"^^ . _:b446363837 . _:b446361669 . _:b446362070 . _:b446361997 . _:b446361670 . _:b446361671 . _:b446360937 "15"^^ . _:b446361664 . _:b446361074 . _:b446364125 "2"^^ . _:b446363649 . _:b446361665 . . _:b446361996 . _:b446361666 . _:b446361667 . _:b446360938 "15"^^ . . _:b446361676 . _:b446361085 . _:b446364124 "2"^^ . _:b446361677 . _:b446361999 . _:b446361678 . _:b446361679 . _:b446360939 "15"^^ . _:b446361672 . _:b446362727 . _:b446361084 . _:b446364127 "2"^^ . _:b446361673 . _:b446361998 . _:b446364154 . _:b446361674 . _:b446361675 . _:b446360940 "15"^^ . _:b446361684 . _:b446361087 . _:b446364126 "2"^^ . _:b446361685 . . _:b446360941 "14"^^ . . _:b446361686 . _:b446361993 . _:b446361687 . _:b446361680 . _:b446361086 . _:b446364121 "2"^^ . _:b446361681 . _:b446361992 . _:b446360942 "14"^^ . _:b446361682 . . _:b446361683 . _:b446361692 . _:b446361081 . _:b446364120 "2"^^ . _:b446361693 . _:b446361995 . _:b446360943 "14"^^ . _:b446361694 . _:b446361695 . _:b446361688 . _:b446361080 . _:b446364123 "2"^^ . _:b446361689 . _:b446361994 . _:b446360944 "14"^^ . _:b446361690 . _:b446361691 . _:b446361700 . _:b446361083 . _:b446364122 "2"^^ . _:b446363806 . _:b446361701 . . _:b446360945 "14"^^ . _:b446361702 . _:b446362005 . . _:b446361703 . _:b446361696 . _:b446361082 . _:b446364133 "2"^^ . _:b446363446 . _:b446361697 . _:b446361423 . _:b446362004 . _:b446360946 "14"^^ . _:b446361698 . _:b446361699 . _:b446361708 . _:b446361709 . _:b446364132 "2"^^ . _:b446362007 . _:b446360947 "14"^^ . _:b446361710 . _:b446361711 . _:b446361704 . . _:b446364135 "2"^^ . _:b446361705 . _:b446362006 . _:b446362944 . _:b446360948 "14"^^ . _:b446361706 . . _:b446361707 . _:b446361716 . _:b446361717 . _:b446364134 "2"^^ . _:b446362001 . . _:b446360949 "14"^^ . _:b446361718 . . _:b446361719 . _:b446361712 . _:b446361492 . _:b446364129 "2"^^ . _:b446361713 . _:b446362000 . _:b446360950 "14"^^ . _:b446361714 . . _:b446361715 . _:b446361724 . _:b446363008 . _:b446361725 . _:b446364128 "2"^^ . _:b446362003 . _:b446360951 "14"^^ . _:b446361726 . . _:b446361727 . _:b446361720 . . _:b446364131 "2"^^ . _:b446361721 . _:b446362002 . _:b446360952 "14"^^ . _:b446361722 . . _:b446361723 . _:b446361604 . _:b446361605 . _:b446364130 "2"^^ . _:b446360959 "13"^^ . _:b446362013 . _:b446360953 "14"^^ . _:b446361606 . _:b446361607 . _:b446363834 . _:b446361600 . . _:b446364141 "2"^^ . _:b446360958 "13"^^ . _:b446361601 . _:b446362012 . _:b446360954 "14"^^ . _:b446361602 . _:b446361603 . _:b446361612 . _:b446361613 . _:b446364140 "2"^^ . _:b446360957 "13"^^ . _:b446362015 . _:b446361614 . _:b446361615 . _:b446361608 . _:b446361609 . _:b446364143 "2"^^ . _:b446360956 "13"^^ . _:b446362014 . _:b446361610 . _:b446361611 . _:b446361620 . _:b446361621 . _:b446364142 "2"^^ . _:b446360955 "13"^^ . _:b446362009 . _:b446361622 . _:b446361623 . _:b446361616 . . _:b446364137 "2"^^ . _:b446363855 . _:b446361617 . _:b446362008 . _:b446363508 . . _:b446361618 . _:b446361619 . _:b446361628 . _:b446361629 . _:b446364136 "2"^^ . _:b446362011 . _:b446361630 . _:b446361631 . _:b446361624 . _:b446361625 . _:b446364139 "2"^^ . _:b446362010 . _:b446361626 . . . _:b446361627 . _:b446361636 . _:b446360967 "12"^^ . _:b446361637 . _:b446364138 "2"^^ . _:b446363728 . _:b446362021 . _:b446361638 . _:b446361639 . . _:b446361632 . _:b446361633 . _:b446364149 "2"^^ . _:b446360966 "13"^^ . _:b446362020 . _:b446361634 . _:b446361440 . _:b446361635 . _:b446361644 . _:b446361645 . _:b446364148 "2"^^ . _:b446360965 "13"^^ . _:b446362023 . _:b446363431 . _:b446361646 . _:b446361647 . _:b446361640 . _:b446361641 . _:b446364151 "2"^^ . _:b446360964 "13"^^ . _:b446362022 . _:b446361642 . . . _:b446361643 . . _:b446361652 . _:b446361653 . _:b446364150 "2"^^ . _:b446360963 "13"^^ . _:b446362017 . _:b446361654 . _:b446361655 . _:b446364098 . . . _:b446361648 . _:b446361649 . _:b446364145 "2"^^ . _:b446360962 "13"^^ . . _:b446362016 . _:b446361650 . . _:b446361651 . _:b446361660 . _:b446361661 . _:b446364144 "2"^^ . _:b446363484 . _:b446360961 "13"^^ . _:b446362019 . _:b446361662 . _:b446361663 . _:b446361656 . _:b446361657 . _:b446364147 "2"^^ . . _:b446360960 "13"^^ . _:b446362018 . _:b446361658 . _:b446361659 . _:b446362052 . _:b446360975 "12"^^ . _:b446361992 . _:b446362053 . _:b446364146 "2"^^ . _:b446362029 . _:b446362870 . _:b446362054 . _:b446362055 . _:b446362048 . _:b446360974 "12"^^ . _:b446362049 . _:b446364157 "2"^^ . _:b446362028 . _:b446362050 . _:b446362051 . _:b446362060 . _:b446360973 "12"^^ . . _:b446364156 "2"^^ . _:b446362061 . _:b446362031 . _:b446362062 . _:b446362063 . _:b446362056 . _:b446363155 . _:b446360972 "12"^^ . _:b446362057 . _:b446364159 "2"^^ . _:b446361195 . . _:b446362058 . _:b446362030 . . _:b446362059 . _:b446362068 . _:b446360971 "12"^^ . _:b446362069 . _:b446364158 "2"^^ . _:b446362025 . _:b446362070 . _:b446362071 . _:b446362064 . _:b446360970 "12"^^ . _:b446362289 . _:b446364153 "2"^^ . _:b446362664 . _:b446362065 . _:b446362024 . _:b446362066 . _:b446361229 . _:b446362067 . . _:b446360969 "12"^^ . _:b446362076 . _:b446362077 . _:b446364152 "2"^^ . _:b446362027 . _:b446362078 . _:b446361352 . _:b446362079 . _:b446362072 . _:b446360968 "12"^^ . _:b446362242 . _:b446364155 "2"^^ . _:b446362073 . _:b446362026 . _:b446362074 . . _:b446362075 . . _:b446360983 "12"^^ . _:b446362084 . _:b446362085 . _:b446364154 "2"^^ . _:b446362037 . _:b446362086 . _:b446362087 . _:b446362080 . _:b446363444 . _:b446360982 "12"^^ . _:b446362081 . _:b446362036 . _:b446362082 . _:b446361131 . _:b446363672 . _:b446362083 . _:b446361212 . _:b446364222 . _:b446360981 "12"^^ . _:b446362092 . _:b446362093 . _:b446362039 . _:b446362094 . _:b446362095 . _:b446362088 . _:b446360980 "12"^^ . . _:b446362089 . _:b446362038 . _:b446362090 . _:b446362091 . _:b446362100 . _:b446362357 . _:b446360979 "12"^^ . _:b446362101 . _:b446363943 . _:b446362578 . _:b446362033 . _:b446362102 . . _:b446362302 . _:b446362103 . _:b446362096 . _:b446360978 "12"^^ . . _:b446362097 . _:b446362032 . . _:b446362098 . _:b446362099 . _:b446362108 . _:b446360977 "12"^^ . _:b446362109 . _:b446362035 . _:b446362110 . _:b446362111 . . _:b446360976 "12"^^ . _:b446362104 . _:b446362105 . _:b446362424 . _:b446362034 . _:b446362662 . _:b446362106 . _:b446362107 . _:b446360991 "11"^^ . _:b446361988 . _:b446361989 . _:b446362045 . _:b446361990 . _:b446361991 . _:b446360990 "11"^^ . . _:b446361984 . . _:b446361985 . _:b446362044 . _:b446361986 . _:b446361987 . _:b446360989 "11"^^ . _:b446361996 . _:b446363048 . _:b446361997 . _:b446362660 . _:b446362047 . _:b446361998 . _:b446361999 . _:b446360988 "11"^^ . . _:b446361992 . . _:b446361993 . _:b446362046 . _:b446361994 . _:b446361995 . _:b446360987 "11"^^ . _:b446362004 . _:b446362005 . _:b446362041 . _:b446362006 . . _:b446364616 . _:b446360986 "11"^^ . _:b446362007 . _:b446362000 . _:b446362001 . _:b446362040 . _:b446362906 . _:b446362002 . . _:b446362003 . _:b446360985 "11"^^ . _:b446362012 . _:b446362013 . _:b446362043 . _:b446362014 . _:b446362015 . _:b446360984 "11"^^ . _:b446362008 . _:b446362009 . _:b446362042 . _:b446362010 . _:b446362011 . _:b446360999 "11"^^ . _:b446362020 . _:b446362021 . _:b446362053 . _:b446363335 . _:b446362022 . _:b446362023 . _:b446360998 "11"^^ . _:b446362016 . _:b446362017 . . _:b446362018 . _:b446362052 . _:b446362019 . _:b446360997 "11"^^ . _:b446362028 . _:b446362029 . _:b446362055 . _:b446362030 . _:b446362031 . _:b446360996 "11"^^ . _:b446362123 . _:b446361947 . _:b446362024 . _:b446362025 . _:b446362054 . _:b446362026 . _:b446362027 . _:b446360995 "11"^^ . _:b446362036 . _:b446362037 . _:b446362049 . _:b446362038 . . _:b446360994 "11"^^ . _:b446362039 . _:b446362032 . _:b446362033 . _:b446362048 . _:b446362034 . _:b446362035 . _:b446360993 "11"^^ . _:b446362044 . _:b446361114 . _:b446362045 . _:b446362051 . . _:b446362046 . _:b446362047 . _:b446360992 "11"^^ . _:b446362040 . _:b446362041 . _:b446362737 . _:b446362050 . _:b446362042 . _:b446362043 . _:b446361007 "11"^^ . _:b446361924 . . . . _:b446361925 . _:b446362061 . _:b446362632 . _:b446361926 . . _:b446361927 . _:b446361006 "11"^^ . . _:b446363613 . _:b446361920 . _:b446361921 . _:b446364388 . . _:b446361922 . _:b446362060 . _:b446361923 . _:b446361005 "11"^^ . . _:b446364597 . _:b446361932 . _:b446361933 . _:b446362063 . _:b446361934 . _:b446361935 . _:b446361004 "11"^^ . _:b446361928 . _:b446363233 . _:b446361929 . _:b446362062 . _:b446361930 . _:b446361931 . _:b446361003 "11"^^ . _:b446361688 . _:b446361940 . _:b446361941 . _:b446362057 . _:b446361942 . _:b446361943 . _:b446361002 "11"^^ . _:b446361936 . _:b446361937 . _:b446363581 . _:b446362056 . _:b446361938 . . _:b446361939 . _:b446361001 "11"^^ . _:b446361948 . _:b446361401 . _:b446361949 . _:b446362059 . _:b446361950 . . _:b446361951 . . _:b446361000 "11"^^ . _:b446361745 . _:b446361944 . _:b446361945 . . _:b446361015 "10"^^ . _:b446361946 . _:b446362058 . _:b446361947 . _:b446361956 . _:b446361957 . . _:b446361014 "10"^^ . _:b446361958 . _:b446362069 . _:b446361959 . _:b446361952 . _:b446361953 . _:b446362068 . _:b446361013 "10"^^ . _:b446361954 . _:b446361955 . _:b446361964 . _:b446361965 . _:b446362071 . _:b446361012 "10"^^ . _:b446361966 . _:b446361172 . _:b446361967 . . _:b446361960 . _:b446361961 . _:b446362070 . _:b446361962 . _:b446361963 . _:b446361011 "11"^^ . _:b446361972 . _:b446361973 . _:b446362065 . _:b446361974 . _:b446361975 . _:b446361010 "11"^^ . _:b446361968 . . _:b446361969 . _:b446362064 . _:b446361970 . . _:b446361009 "11"^^ . _:b446361971 . _:b446361980 . _:b446361981 . _:b446362067 . _:b446361982 . _:b446361983 . _:b446361008 "11"^^ . . _:b446361976 . _:b446361922 . _:b446361977 . . . _:b9113986 "We estimated the tumor doubling time was equal to the cell doubling time (Tgen) until the tumor size reached 100 microns in diameter at which time angiogenesis is required >>21<<. Thereafter, we used the median doubling time described above." . _:b446364555 . _:b446361023 "10"^^ . _:b446361978 . _:b446362066 . . _:b446361979 . _:b446361860 . _:b446361861 . _:b446362077 . _:b446361022 "10"^^ . _:b446361862 . _:b446361863 . _:b446361856 . . _:b446361857 . _:b446362076 . _:b446361021 "10"^^ . _:b446361858 . . . _:b446361859 . _:b446361868 . . _:b446361869 . . _:b446362079 . _:b446361020 "10"^^ . _:b446361870 . . _:b446361871 . _:b446361864 . _:b446363428 . _:b446361865 . _:b446362078 . _:b446361019 "10"^^ . _:b446361866 . . . _:b446361867 . _:b446361890 . _:b446361876 . _:b446361877 . _:b446362073 . _:b446363216 . _:b446362423 . _:b446361018 "10"^^ . _:b446361878 . _:b446361879 . . _:b446361872 . _:b446361873 . _:b446362072 . _:b446361017 "10"^^ . _:b446361874 . _:b446361875 . _:b446361925 . _:b446361884 . _:b446361885 . _:b446362075 . _:b446361016 "10"^^ . _:b446361886 . . _:b446361887 . _:b446361880 . _:b446361881 . _:b446362074 . _:b446361031 "10"^^ . _:b446361882 . _:b446361883 . _:b446361892 . _:b446361893 . _:b446362085 . _:b446361030 "10"^^ . _:b446361894 . _:b446361895 . _:b446364243 . _:b446361888 . _:b446361889 . _:b446362084 . _:b446363826 . _:b446361029 "10"^^ . _:b446361890 . _:b446361891 . _:b446361900 . _:b446361901 . _:b446362087 . _:b446361028 "10"^^ . _:b446361902 . _:b446361903 . _:b446361896 . _:b446361897 . . _:b446364540 . _:b446361027 "10"^^ . _:b446361898 . _:b446361330 . _:b446362086 . _:b446361899 . _:b446361908 . _:b446361909 . _:b446362081 . _:b446361026 "10"^^ . _:b446361910 . _:b446361911 . _:b446361904 . _:b446361905 . _:b446362080 . _:b446361025 "10"^^ . _:b446361906 . _:b446361907 . . _:b446361916 . _:b446361917 . _:b446362083 . _:b446361024 "10"^^ . _:b446361918 . . _:b446361919 . _:b446361912 . . _:b446361913 . _:b446362082 . _:b446361039 "10"^^ . _:b446361914 . _:b446361081 . _:b446361915 . . _:b446364265 . _:b446362093 . _:b446361038 "10"^^ . _:b446362092 . _:b446361037 "10"^^ . . _:b446362095 . _:b446361036 "10"^^ . . . _:b446364599 . . _:b446361035 "10"^^ . _:b446361265 . _:b446362094 . _:b446363568 . _:b446361067 . . _:b446362089 . _:b446361034 "10"^^ . . . . _:b446361233 . _:b446361033 "10"^^ . _:b446362088 . . _:b446364246 . _:b446362091 . _:b446361032 "10"^^ . . _:b446362090 . . _:b446362101 . _:b446361046 "10"^^ . _:b446361047 "9"^^ . _:b446362100 . _:b446363741 . _:b446361045 "10"^^ . . _:b446362103 . _:b446363775 . _:b446361044 "10"^^ . . . _:b446361043 "10"^^ . _:b446362102 . . _:b446364236 . _:b446362097 . _:b446362615 . _:b446361042 "10"^^ . . _:b446363831 . _:b446362096 . _:b446361041 "10"^^ . . _:b446361040 "10"^^ . _:b446362099 . _:b446362098 . _:b446361054 "9"^^ . _:b446362109 . _:b446361226 . . _:b446361055 "9"^^ . _:b446362108 . _:b446362541 . . _:b446361052 "9"^^ . _:b446362111 . _:b446361053 "9"^^ . _:b446363648 . _:b446362110 . _:b446361050 "9"^^ . _:b446362105 . _:b446362128 . _:b446361051 "9"^^ . _:b446362104 . _:b446361048 "9"^^ . _:b446362107 . _:b446364309 . _:b446361049 "9"^^ . _:b446362106 . _:b446361062 "9"^^ . _:b446361605 . . _:b446361063 "9"^^ . . _:b446361604 . _:b446361060 "9"^^ . _:b446361607 . _:b446361061 "9"^^ . _:b446361606 . _:b446361058 "9"^^ . _:b446361601 . _:b446361690 . _:b446362132 . _:b446361059 "9"^^ . _:b446361600 . _:b446361056 "9"^^ . _:b446361603 . . _:b446361057 "9"^^ . . _:b446361602 . _:b446361070 "9"^^ . _:b446361613 . _:b446363020 . _:b446361071 "9"^^ . _:b446361612 . . _:b446361068 "9"^^ . _:b446361615 . . . _:b446361069 "9"^^ . _:b446361614 . _:b446361066 "9"^^ . _:b446361609 . _:b446363677 . _:b446361443 . _:b446361067 "9"^^ . _:b446361608 . . _:b446362603 . _:b446361064 "9"^^ . _:b446361611 . _:b446361065 "9"^^ . . _:b446361610 . _:b446361078 "9"^^ . _:b446361621 . _:b446361079 "9"^^ . _:b446361620 . _:b446361711 . _:b446361076 "9"^^ . _:b446362115 . _:b446361623 . _:b446361077 "9"^^ . _:b446364368 . _:b446361622 . _:b446361074 "9"^^ . _:b446361617 . _:b446361075 "9"^^ . _:b446361616 . _:b446361072 "9"^^ . _:b446361619 . _:b446361073 "9"^^ . _:b446361618 . _:b446361086 "8"^^ . _:b446361629 . _:b446363458 . _:b446361087 "8"^^ . _:b446361628 . _:b446361084 "8"^^ . _:b446361631 . _:b446364408 . _:b446361085 "8"^^ . . _:b446361630 . . _:b446361082 "8"^^ . . _:b446361625 . _:b446363556 . _:b446361083 "8"^^ . _:b446361624 . _:b446361080 "8"^^ . _:b446362981 . _:b446361627 . _:b446361379 . . _:b446361081 "8"^^ . . _:b446361626 . . . _:b446361637 . . _:b446361636 . _:b446361324 . _:b446363605 . _:b446361639 . _:b446364170 . _:b446361638 . _:b446360997 . _:b446360911 . _:b446361633 . . _:b446361632 . _:b446361635 . . . _:b446361572 . . _:b446364378 . _:b446361634 . . . _:b446361645 . . _:b446361644 . . _:b446361647 . . _:b446361646 . . _:b446361641 . _:b446362142 . _:b446362025 . _:b446361640 . _:b446364315 . _:b446361735 . . _:b446361643 . _:b446361904 . _:b446361642 . _:b446361653 . _:b446360940 . _:b446364164 . _:b446361652 . _:b446362064 . _:b446361655 . . . _:b446361654 . . . _:b446361558 . _:b446364276 . _:b446362250 . _:b446361649 . _:b446361648 . _:b446361651 . . _:b446361650 . _:b446360906 . _:b446362547 . _:b446363958 . _:b446361661 . _:b446361660 . _:b446361663 . _:b446361662 . _:b446361657 . _:b446362103 . _:b446361656 . _:b446361659 . _:b446361658 . _:b446364464 . . _:b446361669 . . . . _:b446361668 . _:b446363401 . _:b446363789 . _:b446363064 . _:b446361671 . _:b446361670 . . _:b446361665 . . _:b446361664 . _:b446361667 . _:b446361666 . _:b446361043 . . . _:b446361677 . . _:b446363054 . _:b446361676 . _:b446362888 . . _:b446361679 . . _:b446364167 . _:b446363351 . . _:b446361678 . . _:b446361673 . . _:b446361239 . . _:b446361672 . _:b446361032 . _:b446361675 . _:b446361908 . _:b446362866 . _:b446361674 . . _:b446361685 . _:b446361977 . . . _:b446361684 . _:b446362706 . . . _:b446362197 . _:b446361687 . _:b446362393 . . _:b446361686 . . _:b446361681 . _:b446361680 . _:b446361683 . _:b446361682 . _:b446361693 . _:b446364442 . _:b446361692 . _:b446362524 . _:b446362451 . _:b446361695 . _:b446361694 . . . _:b446361689 . _:b446363830 . . _:b446361688 . . . _:b446362537 . _:b446361691 . . _:b446361690 . . _:b446361701 . _:b446361608 . _:b446362554 . _:b446361700 . . . _:b446361703 . _:b446361702 . . _:b446361899 . _:b446361697 . _:b446364004 . _:b446361118 . _:b446361696 . . _:b446361699 . _:b446363169 . _:b446361698 . _:b446361709 . . _:b446361708 . _:b446361711 . _:b446363384 . _:b446361710 . _:b446361705 . . . _:b446361870 . _:b446361704 . . . _:b446361707 . _:b446361937 . _:b446361706 . _:b446362872 . _:b446361717 . _:b446361716 . . _:b446361719 . _:b446362836 . _:b446362850 . _:b446361718 . _:b446361713 . _:b446361712 . . _:b446361288 . . _:b446361715 . _:b446364257 . _:b446361714 . . _:b446361725 . _:b446361724 . _:b446362190 . _:b446361292 . _:b446361727 . . . _:b446361726 . _:b446361527 . . _:b446363740 . . . _:b446361721 . _:b446364346 . _:b446361720 . _:b446363699 . . . _:b446363934 . _:b446361723 . _:b446361447 . _:b446361722 . _:b446361733 . . _:b446361732 . _:b446363279 . _:b446361735 . _:b446361734 . _:b446361729 . . _:b446362600 . _:b446363779 . _:b446361728 . _:b446364537 . . _:b446363574 . _:b446360923 . _:b446362873 . _:b446361731 . _:b9113989 "methods summary" . _:b446361730 . . . _:b446361741 . . . _:b446361740 . _:b446361743 . . _:b446362032 . _:b446361742 . _:b446364119 . _:b446361737 . . _:b446361736 . _:b446362062 . _:b446361739 . . _:b446364515 . _:b446362120 . _:b446361497 . _:b446361738 . _:b446361749 . _:b446361748 . _:b446363217 . _:b446361297 . _:b446361751 . _:b446362001 . _:b446361750 . _:b446362337 . _:b446361745 . _:b446363617 . _:b446361744 . . . _:b446361747 . . _:b446363673 . . _:b446361746 . _:b446361720 . . _:b446361757 . _:b446362387 . _:b446361756 . . . _:b446361759 . _:b446364458 . _:b446362886 . _:b446364293 . _:b446361758 . . . _:b446361753 . . . . . _:b446361752 . . . . . _:b446361755 . . _:b446361514 . _:b446361754 . _:b446361765 . _:b446363412 . _:b446361764 . . _:b446361767 . _:b446361766 . _:b446361761 . _:b446361747 . . _:b446361760 . . _:b446361763 . . _:b446361762 . _:b446364539 . . . _:b446361773 . . _:b446364401 . . . _:b446364478 . _:b446361772 . . _:b446361775 . _:b446361774 . _:b446364573 . _:b446361769 . _:b446362525 . _:b446361768 . . _:b446364138 . _:b446361771 . . _:b446361074 . _:b446361770 . . _:b446361781 . . _:b446361780 . _:b446364043 . . _:b446361783 . . _:b446361782 . _:b446361691 . _:b446363606 . _:b446361777 . . _:b446361776 . . _:b446361779 . . _:b446361778 . . _:b446363104 . _:b446361789 . _:b446361375 . _:b446361943 . _:b446361788 . _:b446361791 . _:b446361790 . . _:b446364344 . _:b446361785 . . . _:b446361784 . _:b446362538 . . _:b446364385 . _:b446361787 . _:b446360988 . _:b446363145 . _:b446362021 . _:b446361786 . . . . _:b446361797 . _:b446361464 . _:b446361796 . _:b446361428 . _:b446361799 . . _:b446363941 . _:b446361798 . . . _:b446364504 . _:b446361793 . . _:b446361792 . . _:b446361795 . _:b446362953 . _:b446361794 . . . _:b446361805 . _:b446363829 . _:b446361804 . _:b446362877 . . _:b446363366 . _:b446361807 . _:b446362991 . _:b446361806 . _:b446361801 . _:b446363945 . . _:b446361800 . . _:b446363071 . . _:b446361803 . _:b446361802 . _:b446362221 . _:b446361813 . _:b446361075 . _:b446362363 . . _:b446361812 . . _:b446361815 . . . _:b446362215 . _:b446361814 . . _:b446361809 . _:b446360931 . . _:b446361808 . _:b446362195 . . _:b446361509 . _:b446364316 . _:b446361811 . . _:b446361810 . . _:b446361358 . _:b446361708 . _:b446360896 . _:b446361821 . _:b446362899 . _:b446363965 . _:b446361348 . _:b446361820 . . . . _:b446361823 . . _:b446361822 . _:b446361948 . . . _:b446361817 . . . _:b446361816 . _:b446361803 . _:b446361819 . . _:b446363790 . _:b446361818 . _:b446361671 . _:b446361829 . _:b446364245 . _:b446361314 . _:b446361828 . _:b446361831 . _:b446362746 . _:b446361830 . _:b446361825 . _:b446361824 . _:b446361090 . _:b446364240 . _:b446362046 . _:b446361157 . . _:b446361827 . . _:b446362011 . . . _:b446361826 . . _:b446361837 . _:b446363241 . . _:b446361836 . _:b446362597 . _:b446362369 . _:b446361839 . _:b446362382 . _:b446361838 . _:b446363627 . _:b446361833 . _:b446362252 . . _:b446361832 . . . _:b446363226 . _:b446361835 . . . _:b446361834 . _:b446361845 . _:b446363452 . _:b446361844 . _:b446362649 . _:b446364481 . . . _:b446361847 . . _:b446362763 . . _:b446361846 . . . _:b446361841 . _:b446361840 . . _:b446362680 . _:b446361610 . _:b446361843 . . _:b446361276 . _:b446361842 . _:b446363752 . _:b446364498 . _:b446361853 . _:b446362711 . _:b446363021 . _:b446361852 . _:b446362820 . _:b446361855 . _:b446361854 . _:b446361849 . _:b446364201 . _:b446361848 . . _:b446361851 . _:b446363114 . _:b446364036 . _:b446361850 . _:b446361805 . _:b446362843 . _:b446362678 . . _:b446364126 . _:b446363199 . . _:b446361407 . . _:b446363124 . _:b446363392 . _:b446362350 . _:b446362345 . _:b446361926 . _:b446364172 . _:b446364000 . . _:b446363070 . . _:b446362588 . _:b446364072 . _:b446361309 . _:b446363125 . . _:b446362259 . . _:b446361815 . . . _:b446364449 . . . . . _:b446361587 . _:b446364667 . . . _:b446362285 . _:b446362979 . _:b446362225 . _:b446363838 . _:b446364484 . _:b446364536 . . _:b446362846 . _:b446364487 . _:b446360916 . _:b446363360 . _:b446360939 . _:b446364127 . . _:b446363487 . . _:b446361578 . . _:b446363615 . . . _:b446364466 . . _:b446361449 . _:b446361888 . . _:b446361853 . _:b446361150 . _:b446361000 . _:b446360884 . . _:b446363188 . _:b446362380 . . . _:b446362665 . . . _:b446363822 . . . _:b446364438 . . _:b446361575 . . . _:b446362435 . _:b446363223 . . . . . _:b446364197 . . _:b446363537 . . _:b446364198 . . _:b446363161 . _:b446363921 . _:b446364035 . _:b446363716 . . _:b446364657 . . _:b446362416 . . _:b446362708 . _:b446362598 . . _:b446364440 . _:b446362307 . . _:b446364275 . _:b446363915 . _:b446363341 . . _:b446361567 . _:b446363853 . _:b446363033 . . _:b446362879 . _:b446361429 . _:b446363719 . _:b446362818 . _:b446362854 . . _:b446361672 . . _:b446363682 . _:b446364648 . _:b446364595 . . . . . _:b446361140 . _:b446362111 . . . _:b446363513 . _:b446362280 . _:b446361523 . _:b446361978 . . . _:b446361263 . . _:b446361124 . _:b446362160 . _:b446364090 . _:b446363260 . _:b446363825 . _:b446361597 . _:b446363065 . . _:b446363569 . . . _:b446362851 . _:b446361836 . . . . . _:b446363771 . . . _:b446361838 . . _:b446363807 . _:b446364281 . _:b446362264 . _:b446362431 . _:b446361404 . _:b446364012 . _:b446361861 . _:b446363668 . _:b446361384 . _:b446362049 . _:b446363232 . . _:b446362900 . . . . _:b446361964 . . _:b446364511 . . . . . . _:b446361666 . . . . . _:b446361105 . _:b446362353 . _:b446362952 . . _:b446363571 . _:b446363311 . _:b446362305 . _:b446361391 . . . _:b446362532 . . . . . . _:b446361679 . _:b446363509 . . _:b446362185 . . . _:b446361941 . . _:b446362240 . _:b446361819 . _:b446361782 . . . _:b446361307 . _:b446363914 . . _:b446363053 . . . _:b446361974 . . . _:b446362024 . _:b446363804 . _:b446363317 . _:b446363773 . _:b9113977 "Xenograft enriched or low passage cell lines were generated from the post mortem cancer tissues of these seven patients as previously described >>13<<,14." . _:b446364123 . . . . . _:b446361958 . . . _:b446361556 . _:b446361621 . _:b446364021 . . _:b446364189 . . _:b446361827 . _:b446362368 . _:b446361395 . . _:b446363090 . _:b446363793 . _:b446364606 . . . . _:b446362471 . _:b446362997 . _:b446362713 . . . _:b446363347 . _:b446362167 . . _:b446363087 . . . . . . . . _:b446364030 . _:b446363603 . _:b446361544 . . . . . _:b446362083 . _:b446362014 . _:b446361541 . . . _:b446362007 . _:b446360920 . _:b446362122 . . _:b446364403 . . . _:b446361910 . _:b446363331 . . . . _:b446363462 . _:b446362370 . . _:b446362682 . _:b446364549 . . . _:b446364598 . _:b446363283 . . _:b446361909 . . _:b446361243 . _:b446361335 . _:b446360921 . . _:b446361580 . _:b446362534 . _:b446362277 . . _:b446363329 . . . . . . . _:b446361374 . _:b446362761 . . _:b446363333 . _:b446364431 . . _:b446362392 . _:b446363956 . . _:b446363797 . . . . . . _:b446363540 . . . . _:b9113983 "Assuming a median value for the S-phase duration in human tissues and tumors, Ts, of 10 hours >>18<<, and using the formula for the potential cell doubling time Tpot=\u03BBTs/LI, we get an estimate for Tpot of 3.5 days." . _:b446362326 . _:b446363848 . . . _:b446361771 . . _:b446364071 . _:b446360883 . _:b446361505 . . . . _:b446361277 . _:b446361876 . _:b446364620 . _:b446364560 . . . . _:b446364096 . _:b446362335 . . _:b446361141 . _:b446361661 . _:b446361009 . . _:b446363381 . _:b446361168 . . _:b446361284 . _:b446363582 . . . . . . _:b446361219 . _:b446364070 . _:b446363001 . _:b446363692 . _:b446364483 . _:b446363653 . . _:b446363751 . _:b446362740 . . . _:b446364496 . . . _:b446363215 . _:b446361629 . _:b446364017 . _:b446360979 . _:b446360952 . . _:b446360852 . _:b446363423 . . . _:b446363586 . _:b446362890 . _:b446363245 . . _:b446362790 . _:b446362134 . _:b446363013 . _:b446364601 . _:b446364263 . _:b446362283 . . _:b446363276 . _:b446362971 . _:b446363183 . . _:b446363425 . . _:b446364216 . _:b446362417 . . _:b446362265 . . . _:b446361537 . _:b446360853 . _:b446361442 . _:b446363833 . _:b446364531 . _:b446363377 . _:b446364195 . . . . _:b446363818 . . . . . . . . . _:b446362028 . _:b446363382 . . _:b446363406 . . _:b446363194 . _:b446361519 . _:b446362162 . _:b446364307 . . . . _:b446364014 . . _:b446362755 . _:b9113975 "methods" . . . . _:b446364425 . . _:b446364522 . _:b446361503 . _:b446363133 . _:b446361253 . . _:b446363992 . _:b446361112 . . . _:b446363225 . . _:b446364507 . _:b446364031 . . _:b446364085 . _:b446363362 . . _:b446362503 . . . . _:b446362833 . . . . . . _:b446364407 . _:b446362084 . _:b446363074 . _:b446361259 . _:b446361027 . . . _:b446360985 . _:b446364528 . . . _:b446362745 . _:b446364329 . _:b446364249 . _:b446364165 . . _:b446361761 . . _:b446364174 . . . _:b446363159 . _:b446361169 . . _:b446361127 . _:b446363870 . _:b446364364 . . _:b446362405 . _:b446364118 . . . . _:b446361636 . . _:b446364342 . . _:b446363573 . . _:b446363252 . . . . _:b446361618 . . . _:b446362802 . _:b446364299 . _:b446363170 . _:b446362433 . _:b446361328 . . _:b446361665 . _:b446361322 . . _:b446362771 . _:b446363725 . _:b446364469 . _:b446363222 . _:b446364053 . . _:b446362294 . _:b446360929 . _:b446361133 . _:b446360914 . _:b446363295 . _:b446363565 . _:b446362945 . . _:b446361068 . _:b446363824 . . . . _:b446361101 . _:b446364340 . . _:b446364008 . . . . . . _:b446362161 . _:b446361755 . . . _:b446362275 . _:b446362569 . _:b446362401 . _:b446362937 . _:b446361972 . _:b446364550 . _:b446361493 . _:b446362759 . . _:b446364041 . . . . . . . . _:b446363520 . _:b446361083 . _:b446362882 . . _:b446363030 . . _:b446361563 . _:b446364584 . _:b446362648 . . . _:b446362231 . _:b446362651 . _:b446362315 . _:b446363035 . . . . . . _:b446361938 . . _:b446363765 . . . . _:b446361529 . _:b446364067 . . . _:b446362595 . _:b446363096 . . . . . . . . . . _:b446360850 . _:b446362358 . . _:b446361991 . . . . _:b446361612 . . _:b446362677 . . . _:b446363137 . . _:b446362174 . _:b446362669 . _:b446362813 . . . . _:b446364437 . _:b446362490 . _:b446360893 . . . _:b446361539 . _:b446361718 . _:b446362580 . . . . _:b446362438 . . _:b446364544 . . _:b446363705 . . _:b446363098 . . . _:b446360951 . _:b446364380 . _:b446363874 . . _:b446362204 . _:b446363267 . _:b446363284 . _:b446361748 . _:b446361275 . _:b446361824 . _:b446361203 . _:b446362652 . . . _:b446361600 . . . . . . . . _:b446361316 . _:b446364377 . . . . . _:b446360900 . _:b446363850 . _:b446364317 . . . . _:b446360999 . _:b446361033 . _:b446360891 . _:b446364102 . _:b446362009 . . . . . _:b446364232 . _:b446361344 . _:b446363974 . . _:b446361018 . . _:b446362364 . _:b446362865 . . _:b446363278 . _:b446361490 . _:b446362484 . . _:b446363721 . . . _:b446362172 . _:b446361003 . _:b446362842 . _:b446360898 . . _:b446363206 . _:b446362951 . . . _:b446363037 . _:b446362310 . . _:b446363547 . _:b446361454 . . . _:b446360899 . . _:b446361703 . . . . . . . . . . _:b446362692 . . . . . _:b446363781 . _:b446364582 . _:b446363135 . _:b446360954 . . . _:b446363340 . _:b446360941 . _:b446362000 . . . _:b446362863 . _:b446363999 . _:b446364395 . _:b446364148 . . _:b446363639 . . _:b446362056 . . . _:b446361295 . _:b446362696 . _:b446362415 . . _:b446362739 . . _:b446362399 . _:b446361903 . _:b446363763 . _:b446363811 . . . _:b446361120 . _:b446361339 . . _:b446361144 . _:b446362663 . _:b446363693 . . . . . _:b446362898 . _:b446361676 . _:b446361916 . _:b446361577 . _:b446360860 . . . _:b446364422 . . _:b446361148 . . _:b446361624 . _:b446360922 . . _:b446364330 . . _:b446362331 . . . _:b446363308 . _:b446363689 . . . . _:b446364101 . . _:b446361206 . _:b446363051 . _:b446363419 . . . _:b446361607 . _:b446362253 . . . . _:b446361777 . _:b446364349 . _:b446360948 . _:b446363799 . _:b446364046 . _:b446364108 . . . _:b446363821 . . _:b446363468 . _:b446363129 . . _:b446361496 . _:b446364415 . . _:b446362496 . _:b446362637 . _:b446361202 . _:b446362219 . . _:b446361818 . _:b446362557 . _:b446361021 . _:b446362249 . _:b446363305 . _:b446364024 . _:b446363724 . _:b446363972 . . _:b446363237 . . _:b446362295 . . . . . _:b446361859 . . _:b446362891 . . . . . _:b446362518 . _:b446361017 . . . _:b446363633 . _:b446361327 . . _:b446364618 . . _:b446362695 . . _:b446361046 . . _:b446361119 . _:b446364613 . . . . . _:b446363370 . . _:b446360933 . _:b446361705 . . . _:b446362352 . _:b446361874 . _:b446364109 . _:b446364519 . _:b446361697 . _:b446362501 . . _:b446361051 . _:b446362441 . _:b446362507 . _:b446364383 . . _:b446362871 . _:b446361701 . _:b446363950 . _:b446363609 . _:b446361891 . . _:b446362919 . . _:b446362482 . . . _:b446364475 . _:b446362752 . _:b446363466 . _:b446361820 . _:b446364577 . _:b446362562 . . _:b446361501 . . . _:b446362805 . _:b446362963 . _:b446361362 . . . . . . . . . _:b446363319 . _:b446362090 . . . _:b446362269 . _:b446364194 . _:b446361163 . . _:b446360885 . _:b446362593 . . . _:b446361396 . _:b446363321 . _:b446361445 . _:b446364088 . . . . . . . _:b446364182 . . _:b446362821 . _:b446362202 . . . . _:b446361139 . . _:b446364321 . . _:b446363907 . . . . . _:b446362150 . . . . _:b446362931 . _:b446362797 . . . _:b446362270 . _:b446361717 . _:b446361471 . . _:b446364267 . . _:b446364214 . . _:b446364585 . . _:b446362005 . _:b446363955 . _:b446361696 . . _:b446362388 . _:b446362414 . _:b446362513 . _:b446363277 . . . _:b446364188 . . . _:b446363141 "2"^^ . _:b446364217 . _:b446363140 "2"^^ . _:b446363942 . _:b446361613 . _:b446363143 "2"^^ . _:b446363142 "2"^^ . . . _:b446363137 "2"^^ . _:b446363136 "2"^^ . . _:b446363403 . _:b446363139 "2"^^ . . _:b446363138 "2"^^ . _:b446361821 . . _:b446363149 "2"^^ . _:b446361963 . _:b446363148 "2"^^ . _:b446360972 . _:b446363473 . _:b446361695 . _:b446363151 "2"^^ . _:b446363150 "2"^^ . _:b446363145 "2"^^ . _:b446363144 "2"^^ . . _:b446363147 "2"^^ . _:b446361758 . . . _:b446363146 "2"^^ . . . _:b446363157 "2"^^ . _:b446363156 "2"^^ . _:b446363159 "2"^^ . . _:b446363158 "2"^^ . _:b446362036 . . _:b446363153 "2"^^ . _:b446363152 "2"^^ . _:b446363155 "2"^^ . _:b446363154 "2"^^ . . _:b446363165 "2"^^ . . _:b446362699 . _:b446361363 . _:b446363536 . _:b446362573 . _:b446363164 "2"^^ . . _:b446363061 . _:b446363587 . _:b446363167 "2"^^ . _:b446361855 . _:b446362585 . _:b446362822 . _:b446363166 "2"^^ . . _:b446363932 . _:b446361569 . _:b446363161 "2"^^ . _:b446363328 . _:b446363160 "2"^^ . . _:b446361707 . _:b446363163 "2"^^ . . _:b446363162 "2"^^ . . _:b446363173 "2"^^ . . _:b446362476 . _:b446363172 "2"^^ . _:b446363175 "2"^^ . _:b446363174 "2"^^ . _:b446363525 . . _:b446363169 "2"^^ . . . _:b446363168 "2"^^ . _:b446363171 "2"^^ . _:b446363170 "2"^^ . . . _:b446363181 "2"^^ . . . _:b446363180 "2"^^ . _:b446362517 . _:b446363183 "2"^^ . _:b446362436 . _:b446363182 "2"^^ . . _:b446363177 "2"^^ . . . . _:b446363176 "2"^^ . _:b446364590 . _:b446363179 "2"^^ . . _:b446363178 "2"^^ . _:b446363189 "2"^^ . _:b446363188 "2"^^ . _:b446363191 "2"^^ . . . _:b446363190 "2"^^ . _:b446363555 . _:b446363185 "2"^^ . _:b446363184 "2"^^ . _:b446361713 . _:b446363493 . _:b446363187 "2"^^ . . _:b446363186 "2"^^ . . _:b446363197 "2"^^ . . . . _:b446363196 "2"^^ . . _:b446363199 "2"^^ . _:b446363791 . . _:b446361468 . _:b446363198 "2"^^ . _:b446364350 . _:b446363193 "2"^^ . . . _:b446363655 . _:b446361382 . _:b446363192 "2"^^ . _:b446361565 . _:b446363144 . _:b446361426 . _:b446363195 "2"^^ . . . _:b446363094 . . _:b446363194 "2"^^ . _:b446363177 . . . _:b446363205 "2"^^ . _:b446363204 "2"^^ . _:b446363207 "2"^^ . _:b446362003 . _:b446363206 "2"^^ . _:b446360858 . . . _:b446363201 "2"^^ . _:b446362169 . _:b446361093 . _:b446363200 "2"^^ . _:b446361151 . . _:b446363203 "2"^^ . _:b446363202 "2"^^ . _:b446363213 "2"^^ . . _:b446363212 "2"^^ . . _:b446363215 "2"^^ . _:b446363214 "2"^^ . . . . _:b446363209 "2"^^ . _:b446363011 . _:b446363208 "2"^^ . _:b446362619 . _:b446363211 "2"^^ . . _:b446363210 "2"^^ . _:b446361619 . _:b446362673 . _:b446363221 "2"^^ . _:b446364495 . _:b446364612 . . _:b446363220 "2"^^ . . _:b446363223 "2"^^ . _:b446362743 . _:b446363222 "2"^^ . _:b446363217 "2"^^ . _:b446363216 "2"^^ . _:b446363219 "2"^^ . _:b446363218 "2"^^ . . _:b446363229 "2"^^ . _:b446363228 "2"^^ . _:b446363451 . _:b446362587 . _:b446363231 "2"^^ . _:b446361397 . _:b446363230 "2"^^ . . _:b446363225 "2"^^ . _:b446363151 . _:b446361166 . _:b446360991 . _:b446363224 "2"^^ . _:b446361649 . _:b446363227 "2"^^ . _:b446361402 . _:b446363226 "2"^^ . _:b446362700 . . _:b446363237 "2"^^ . . _:b446363236 "2"^^ . . _:b9113986 . _:b446362121 . _:b446362385 . _:b446363239 "2"^^ . _:b446362347 . _:b446363238 "2"^^ . _:b446363209 . . _:b446363233 "2"^^ . _:b446363232 "2"^^ . _:b446363235 "2"^^ . . _:b446363234 "2"^^ . _:b446363245 "2"^^ . . _:b446361438 . . _:b446363244 "2"^^ . _:b446361248 . _:b446361845 . _:b446363247 "2"^^ . _:b446362395 . . _:b446363246 "2"^^ . . _:b446363241 "2"^^ . _:b446361760 . . _:b446361889 . . . _:b446363240 "2"^^ . . . . _:b446361802 . . _:b446361535 . _:b446363243 "2"^^ . _:b446362992 . _:b446363242 "2"^^ . _:b446363835 . _:b446361180 . . _:b446363253 "2"^^ . _:b446362313 . _:b446363252 "2"^^ . . . _:b446363255 "2"^^ . _:b446364370 . _:b446363427 . _:b446364551 . _:b446363254 "2"^^ . _:b446364173 . _:b446363249 "2"^^ . _:b446363857 . _:b446363248 "2"^^ . _:b446363251 "2"^^ . . _:b446362152 . _:b446363250 "2"^^ . _:b446364561 . _:b446361177 . _:b446363868 . _:b446363261 "2"^^ . . _:b446363260 "2"^^ . . _:b446362460 . _:b446363263 "2"^^ . _:b446363402 . _:b446363262 "2"^^ . . _:b446363189 . _:b446363257 "2"^^ . . _:b446363256 "2"^^ . . _:b446363814 . . _:b446363259 "2"^^ . . _:b446362255 . _:b446363258 "2"^^ . _:b446361645 . _:b446363269 "2"^^ . _:b446362804 . _:b446363268 "2"^^ . . _:b446363271 "2"^^ . . _:b446362910 . _:b446363270 "2"^^ . _:b446362666 . _:b446360961 . _:b446363265 "2"^^ . . _:b446363935 . _:b446363264 "2"^^ . . _:b446363894 . _:b446363267 "2"^^ . _:b9113987 "In our calculations, we use the estimate for cell doubling time in pancreatic cancer from the literature >>20<< as the value of Tgen." . _:b446361285 . _:b446363266 "2"^^ . _:b446363277 "2"^^ . _:b446364022 . _:b446363882 . _:b446363276 "2"^^ . _:b446361554 . . _:b446362462 . . _:b446364292 . _:b446363279 "2"^^ . _:b446363278 "2"^^ . . . . . . . . _:b446363273 "2"^^ . _:b446363272 "2"^^ . . _:b446363275 "2"^^ . _:b446363274 "2"^^ . _:b446363285 "2"^^ . _:b446363738 . _:b446363284 "2"^^ . _:b446363890 . _:b446363287 "2"^^ . . . _:b446363778 . _:b446363286 "2"^^ . _:b446363281 "2"^^ . . _:b446364225 . . _:b446363280 "2"^^ . . _:b446363283 "2"^^ . . _:b446363282 "2"^^ . _:b446363823 . _:b446363293 "2"^^ . _:b446362058 . _:b446363292 "2"^^ . _:b446362955 . _:b446361320 . _:b446364084 . _:b446361588 . _:b446363295 "2"^^ . _:b446363294 "2"^^ . _:b446363289 "2"^^ . _:b446363288 "2"^^ . _:b446363291 "2"^^ . _:b446361084 . . . . _:b446363290 "2"^^ . _:b446363994 . . _:b446363988 . _:b446363301 "2"^^ . _:b446363022 . _:b446363300 "2"^^ . _:b446363303 "2"^^ . _:b446364190 . _:b446361513 . . _:b446362694 . _:b446363302 "2"^^ . _:b446363297 "2"^^ . . _:b446362646 . _:b446363296 "2"^^ . . . _:b446363299 "2"^^ . . . _:b446363298 "2"^^ . . . _:b446363309 "2"^^ . _:b446363259 . _:b446363308 "2"^^ . _:b446361444 . _:b446363311 "2"^^ . . _:b446363310 "2"^^ . . _:b446363305 "2"^^ . _:b446363928 . _:b446363304 "2"^^ . _:b446363307 "2"^^ . _:b446363306 "2"^^ . _:b446363680 . _:b446362829 . _:b446363317 "2"^^ . _:b446362409 . _:b446363316 "2"^^ . _:b446364581 . _:b446363319 "2"^^ . _:b446361432 . _:b446363318 "2"^^ . . _:b446363313 "2"^^ . _:b446364018 . _:b446361176 . _:b446363312 "2"^^ . . . . . _:b446363315 "2"^^ . _:b446363314 "2"^^ . _:b446361198 . _:b446361886 . . _:b446363343 . _:b446361019 . _:b446363325 "2"^^ . _:b446363324 "2"^^ . . _:b446363327 "2"^^ . _:b446364624 . _:b446363326 "2"^^ . _:b446363632 . . _:b446364187 . _:b446363321 "2"^^ . _:b446364233 . . _:b446363320 "2"^^ . . _:b446363323 "2"^^ . _:b446364642 . _:b446363322 "2"^^ . . _:b446364574 . _:b446363333 "2"^^ . _:b446364146 . _:b446363332 "2"^^ . _:b446361719 . _:b446360888 . _:b446363335 "2"^^ . _:b446363334 "2"^^ . _:b446363329 "2"^^ . _:b446363299 . _:b446363328 "2"^^ . . _:b446363854 . . _:b446360892 . _:b446363331 "2"^^ . _:b446363330 "2"^^ . _:b446363341 "2"^^ . . . _:b446363340 "2"^^ . _:b446363343 "2"^^ . _:b446363636 . . _:b446363342 "2"^^ . . _:b446363337 "2"^^ . . _:b446363336 "2"^^ . _:b446362329 . _:b446363339 "2"^^ . . . _:b446362716 . _:b446363338 "2"^^ . _:b446363349 "2"^^ . . _:b446363348 "2"^^ . . _:b446363351 "2"^^ . _:b446363342 . _:b446363350 "2"^^ . _:b446363285 . _:b446363900 . _:b446363345 "2"^^ . _:b446363344 "2"^^ . _:b446363347 "2"^^ . _:b446362427 . _:b446361683 . _:b446364357 . _:b446363346 "2"^^ . _:b446363117 . _:b446363357 "2"^^ . _:b446364384 . _:b446362957 . _:b446363356 "2"^^ . . _:b446363359 "2"^^ . . . . _:b446361737 . _:b446364191 . _:b446363358 "2"^^ . . _:b446363353 "2"^^ . _:b446363352 "2"^^ . . . _:b446363991 . _:b446361179 . _:b446363355 "2"^^ . . _:b446361902 . . _:b446361658 . . _:b446363354 "2"^^ . _:b446363365 "2"^^ . _:b446364460 . _:b446361071 . _:b446364421 . _:b446363364 "2"^^ . . _:b446364420 . _:b446363367 "2"^^ . _:b446363366 "2"^^ . _:b446364423 . _:b446363361 "2"^^ . _:b446364422 . _:b446361436 . _:b446361633 . _:b446363360 "2"^^ . _:b446364417 . . _:b446362497 . _:b446363363 "2"^^ . _:b446364416 . . _:b446363362 "2"^^ . _:b446364419 . _:b446363373 "2"^^ . _:b446364418 . . . . _:b446363372 "2"^^ . _:b446364429 . . _:b446363224 . _:b446363375 "2"^^ . _:b446364428 . _:b446363374 "2"^^ . _:b446364431 . _:b446361323 . _:b446363369 "2"^^ . _:b446364430 . _:b446363368 "2"^^ . _:b446364425 . . . . _:b446364424 . _:b446363371 "2"^^ . _:b446363370 "2"^^ . _:b446364427 . _:b446363381 "2"^^ . _:b446364426 . _:b446363380 "2"^^ . _:b446364437 . _:b446363698 . . _:b446363383 "2"^^ . _:b446364436 . . _:b446363382 "2"^^ . _:b446364439 . _:b446363377 "2"^^ . _:b446364438 . _:b446361380 . . _:b446364433 . _:b446363376 "2"^^ . . _:b446363379 "2"^^ . _:b446364432 . _:b446361158 . _:b446362300 . _:b446364435 . _:b446363378 "2"^^ . _:b446363203 . . _:b446363389 "2"^^ . _:b446364434 . _:b446362892 . _:b446363533 . _:b446363388 "2"^^ . _:b446364445 . _:b446363391 "2"^^ . _:b446364444 . . . _:b446363390 "2"^^ . _:b446364447 . . _:b446364100 . _:b446363794 . _:b446363385 "2"^^ . _:b446364446 . _:b446361247 . _:b446363384 "2"^^ . _:b446364441 . . _:b446363350 . . _:b446364440 . _:b446363387 "2"^^ . . . _:b446364443 . _:b446363386 "2"^^ . _:b446362027 . _:b446363243 . . . _:b446363397 "2"^^ . _:b446364442 . _:b446364444 . _:b446363396 "2"^^ . _:b446364453 . _:b446363399 "2"^^ . _:b446364452 . _:b446363623 . _:b446364567 . _:b446363398 "2"^^ . _:b446364455 . _:b446363393 "2"^^ . _:b446364454 . _:b446363661 . . _:b446363392 "2"^^ . _:b446364449 . _:b446361029 . _:b446364448 . _:b446363395 "2"^^ . . _:b446363394 "2"^^ . _:b446364451 . _:b446363405 "2"^^ . _:b446364450 . . _:b9113990 . . _:b446364461 . _:b446363404 "2"^^ . . _:b446363407 "2"^^ . _:b446364460 . . _:b446363406 "2"^^ . _:b446364463 . _:b446363414 . _:b446363401 "2"^^ . _:b446364462 . _:b446363400 "2"^^ . _:b446364626 . _:b446364457 . _:b446363954 . _:b446363403 "2"^^ . _:b446364456 . . . _:b446364459 . _:b446363402 "2"^^ . _:b446362582 . . _:b446363386 . . _:b446363413 "2"^^ . _:b446364458 . _:b446363412 "2"^^ . _:b446364469 . _:b446363415 "2"^^ . _:b446364468 . _:b446363414 "2"^^ . _:b446364471 . _:b446363409 "2"^^ . _:b446364470 . _:b446363408 "2"^^ . _:b446364465 . _:b446363411 "2"^^ . _:b446364470 . _:b446364464 . _:b446363410 "2"^^ . _:b446364467 . . _:b446361593 . . _:b446363421 "2"^^ . _:b446364466 . _:b446361660 . _:b446361072 . . _:b446364477 . _:b446363420 "2"^^ . _:b446363423 "2"^^ . _:b446364476 . . . _:b446364479 . _:b446363422 "2"^^ . . _:b446363952 . . _:b446363417 "2"^^ . _:b446364478 . . _:b446362897 . _:b446363416 "2"^^ . _:b446364473 . . _:b446363419 "2"^^ . _:b446364472 . . _:b446363418 "2"^^ . _:b446364475 . _:b446363685 . . . _:b446363770 . _:b446363429 "2"^^ . _:b446364474 . _:b446363904 . . _:b446364485 . _:b446363428 "2"^^ . _:b446361381 . . _:b446361185 . _:b446363431 "2"^^ . _:b446364484 . . _:b446361473 . . _:b446364361 . _:b446363430 "2"^^ . _:b446364487 . _:b446363425 "2"^^ . _:b446364486 . _:b446363424 "2"^^ . _:b446364481 . _:b446363427 "2"^^ . _:b446364480 . _:b446363426 "2"^^ . _:b446364483 . _:b446361594 . _:b446363437 "2"^^ . _:b446364482 . . . _:b446363436 "2"^^ . _:b446364493 . _:b446363304 . . _:b446363439 "2"^^ . _:b446364492 . _:b446363438 "2"^^ . _:b446364495 . . _:b446363433 "2"^^ . _:b446364494 . _:b446364491 . _:b446362100 . _:b446364489 . _:b446364376 . _:b446363432 "2"^^ . _:b446362564 . . . _:b446363435 "2"^^ . _:b446364488 . . _:b446363434 "2"^^ . _:b446364491 . _:b446362141 . . _:b446363445 "2"^^ . _:b446364490 . _:b446363500 . . _:b446363256 . _:b446363444 "2"^^ . _:b446364501 . . . _:b446364500 . _:b446363447 "2"^^ . _:b446364557 . _:b446363446 "2"^^ . _:b446364503 . . _:b446362333 . _:b446363441 "2"^^ . _:b446364502 . . . _:b446364497 . _:b446363440 "2"^^ . _:b446363570 . . _:b446363443 "2"^^ . _:b446364496 . . _:b446364499 . _:b446363442 "2"^^ . . _:b446363453 "2"^^ . _:b446364498 . _:b446361540 . . _:b446363452 "2"^^ . _:b446364509 . . . _:b446363455 "2"^^ . _:b446364508 . _:b446361652 . _:b446364511 . _:b446363454 "2"^^ . _:b446361354 . _:b446362494 . _:b446363449 "2"^^ . _:b446364510 . _:b446364639 . _:b446363448 "2"^^ . _:b446364505 . _:b446363451 "2"^^ . _:b446364504 . _:b446362022 . _:b446363318 . . _:b446363450 "2"^^ . _:b446364507 . _:b446361194 . _:b446363461 "2"^^ . _:b446364506 . _:b446361080 . . _:b446364009 . _:b446363460 "2"^^ . _:b446364517 . . _:b446363463 "2"^^ . _:b446364516 . . . . _:b446364519 . _:b446363462 "2"^^ . . _:b446363457 "2"^^ . _:b446364518 . . _:b446362924 . _:b446363456 "2"^^ . _:b446364513 . . _:b446361347 . . _:b446363459 "2"^^ . _:b446364512 . . _:b446363458 "2"^^ . _:b446364515 . _:b446363469 "2"^^ . _:b446364514 . . _:b446364525 . _:b446363468 "2"^^ . _:b446363471 "2"^^ . _:b446364524 . _:b446364131 . . _:b446363470 "2"^^ . _:b446364527 . _:b446363465 "2"^^ . _:b446364526 . _:b446363464 "2"^^ . _:b446364532 . _:b446364521 . . _:b446363873 . _:b446363467 "2"^^ . _:b446364520 . . _:b446361780 . _:b446364523 . _:b446363466 "2"^^ . . . . . . _:b446364522 . _:b446363477 "2"^^ . . _:b446362342 . _:b446363476 "2"^^ . _:b446364533 . . . _:b446364532 . _:b446363479 "2"^^ . _:b446362610 . _:b446363478 "2"^^ . _:b446364535 . . _:b446363473 "2"^^ . _:b446364534 . _:b446361178 . _:b446362935 . _:b446363472 "2"^^ . _:b446364529 . . . _:b446363475 "2"^^ . _:b446364528 . . _:b446363474 "2"^^ . _:b446364531 . . . _:b446364530 . _:b446363485 "2"^^ . . _:b446364541 . 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_:b446363985 . _:b446362928 "2"^^ . . _:b446363249 . . _:b446363984 . _:b446363106 . _:b446362931 "2"^^ . _:b446362930 "2"^^ . _:b446363987 . . _:b446362941 "2"^^ . _:b446363986 . _:b446363028 . _:b446361313 . _:b446362940 "2"^^ . _:b446363997 . . _:b446363529 . _:b446363849 . _:b446361552 . _:b446363996 . _:b446362943 "2"^^ . _:b446362217 . _:b446362942 "2"^^ . _:b446363999 . _:b446363158 . _:b446362937 "2"^^ . _:b446363998 . _:b446362936 "2"^^ . _:b446364386 . _:b446363993 . . _:b446362939 "2"^^ . _:b446363992 . _:b446364338 . . . . _:b446362938 "2"^^ . _:b446363995 . _:b446362949 "2"^^ . _:b446363994 . _:b446362948 "2"^^ . _:b446364005 . . _:b446363043 . . . . _:b446360998 . _:b446364004 . _:b446362951 "2"^^ . . _:b446362950 "2"^^ . _:b446364007 . _:b446362945 "2"^^ . _:b446364006 . . _:b446364001 . _:b446362944 "2"^^ . _:b446361518 . _:b446362361 . _:b446364000 . _:b446362947 "2"^^ . _:b446361716 . . . _:b446362946 "2"^^ . _:b446364332 . _:b446364003 . . _:b446363185 . _:b446362957 "2"^^ . _:b446364002 . _:b446362956 "2"^^ . _:b446364013 . _:b446362959 "2"^^ . _:b446364012 . _:b446362958 "2"^^ . _:b446364637 . _:b446364015 . . _:b446361095 . . _:b446364014 . _:b446362953 "2"^^ . _:b446362952 "2"^^ . _:b446364009 . _:b446362955 "2"^^ . _:b446364008 . . . _:b446362954 "2"^^ . _:b446364011 . _:b446361408 . _:b446362965 "2"^^ . _:b446364010 . _:b446363683 . _:b446362964 "2"^^ . _:b446364021 . _:b446362967 "2"^^ . _:b446364020 . . _:b446364023 . _:b446362966 "2"^^ . _:b446362961 "2"^^ . _:b446364022 . . _:b446364439 . _:b446362960 "2"^^ . _:b446364017 . _:b446364419 . _:b446362963 "2"^^ . _:b446364016 . . . _:b446362962 "2"^^ . _:b446364019 . _:b446362102 . _:b446364018 . _:b446362973 "2"^^ . . . _:b446362972 "2"^^ . _:b446364029 . . _:b446362975 "2"^^ . _:b446364028 . . _:b446364517 . . _:b446362974 "2"^^ . _:b446364031 . . _:b446362969 "2"^^ . _:b446364030 . . _:b446362968 "2"^^ . _:b446364025 . _:b446362971 "2"^^ . _:b446364024 . _:b446362970 "2"^^ . _:b446364027 . . . _:b446362981 "2"^^ . _:b446364026 . _:b446364011 . _:b446364477 . _:b446362980 "2"^^ . _:b446364037 . _:b446362293 . _:b446364036 . _:b446363909 . _:b446362983 "2"^^ . _:b446364303 . _:b446362982 "2"^^ . _:b446364039 . _:b446363491 . _:b446362977 "2"^^ . _:b446364038 . . _:b446360947 . . _:b446362976 "2"^^ . _:b446364033 . . _:b446363872 . _:b446362031 . _:b446364032 . _:b446362979 "2"^^ . _:b446362272 . _:b446364300 . _:b446363604 . _:b446362978 "2"^^ . _:b446364035 . _:b446362989 "2"^^ . _:b446364034 . _:b446361692 . _:b446362988 "2"^^ . _:b446364045 . . _:b446364298 . _:b446363293 . _:b446362991 "2"^^ . _:b446364044 . . _:b446361424 . _:b446362216 . _:b446362990 "2"^^ . _:b446364047 . _:b446362985 "2"^^ . _:b446364192 . _:b446364046 . _:b9113990 "Rapid autopsies were performed on seven individuals with Stage IV pancreatic cancer >>13<<. Genomic DNA was extracted from cell lines or xenografts established from one metastasis of each patient and used for exomic sequencing as previously described 5." . _:b446362984 "2"^^ . _:b446364041 . . _:b446364040 . _:b446362987 "2"^^ . _:b446362986 "2"^^ . _:b446364043 . _:b446361787 . . . _:b446362519 . . . _:b446364042 . _:b446362997 "2"^^ . . . _:b446364053 . _:b446362996 "2"^^ . . _:b446362999 "2"^^ . _:b446364052 . _:b446363810 . . _:b446363892 . _:b446362998 "2"^^ . _:b446364055 . _:b446364314 . _:b446362993 "2"^^ . _:b446364054 . _:b446363858 . _:b446362992 "2"^^ . _:b446364049 . . _:b446362995 "2"^^ . _:b446364048 . _:b446362994 "2"^^ . _:b446364051 . _:b446363168 . _:b446363595 . _:b446363005 "2"^^ . _:b446364050 . _:b446363004 "2"^^ . _:b446364061 . _:b446362645 . _:b446363007 "2"^^ . _:b446364060 . . . . _:b446363006 "2"^^ . _:b446364063 . _:b446362800 . _:b446364591 . _:b446363001 "2"^^ . _:b446364062 . . _:b446363596 . _:b446363000 "2"^^ . _:b446364057 . . . . _:b446364056 . _:b446363003 "2"^^ . . _:b446361843 . _:b446363002 "2"^^ . _:b446364059 . _:b446364005 . _:b446364652 . _:b446363013 "2"^^ . _:b446364288 . _:b446364058 . . _:b446363434 . _:b446363012 "2"^^ . _:b446364069 . . _:b446361147 . _:b446363015 "2"^^ . _:b446364068 . . . _:b446363014 "2"^^ . _:b446364071 . _:b446364156 . _:b446363009 "2"^^ . _:b446364070 . . _:b446361007 . . . _:b446364135 . _:b446364065 . _:b446363008 "2"^^ . . _:b446363011 "2"^^ . _:b446364339 . _:b446364064 . . _:b446364067 . _:b446363010 "2"^^ . . . _:b446364074 . _:b446363021 "2"^^ . _:b446364066 . _:b446362962 . _:b446363020 "2"^^ . _:b446364077 . _:b446361786 . _:b446364076 . _:b446363023 "2"^^ . _:b446363281 . . . . _:b446363022 "2"^^ . _:b446364079 . _:b446363962 . . _:b446360894 . _:b446361228 . _:b446364078 . _:b446363017 "2"^^ . _:b446363016 "2"^^ . _:b446364073 . _:b446362824 . _:b446363019 "2"^^ . _:b446364072 . _:b446363396 . _:b446360926 . _:b446363877 . _:b446363018 "2"^^ . _:b446364075 . . . _:b446364074 . _:b446363029 "2"^^ . _:b446363028 "2"^^ . _:b446364085 . _:b446363031 "2"^^ . _:b446364084 . . _:b446364227 . _:b446363030 "2"^^ . _:b446364087 . _:b446363025 "2"^^ . _:b446364086 . _:b446363024 "2"^^ . _:b446364081 . . _:b446362776 . _:b446362052 . _:b446362921 . _:b446362492 . _:b446364080 . _:b446363027 "2"^^ . . _:b446363026 "2"^^ . _:b446364083 . . _:b446363197 . _:b446363037 "2"^^ . _:b446364082 . _:b446363036 "2"^^ . _:b446364093 . _:b446364110 . . _:b446363039 "2"^^ . _:b446364092 . _:b446363470 . _:b446363038 "2"^^ . _:b446364095 . _:b446363033 "2"^^ . _:b446364094 . _:b446363032 "2"^^ . _:b446364089 . . _:b446361669 . . _:b446364088 . _:b446363035 "2"^^ . _:b446361710 . _:b446363034 "2"^^ . _:b446364091 . _:b446362616 . _:b446363045 "2"^^ . _:b446364090 . . _:b446363044 "2"^^ . _:b446364101 . _:b446361837 . _:b446363047 "2"^^ . _:b446364100 . _:b446363380 . _:b446362896 . _:b446364103 . _:b446363046 "2"^^ . _:b446363041 "2"^^ . _:b446364102 . . . _:b446363040 "2"^^ . _:b446364097 . _:b9113980 . . _:b446364096 . _:b446363043 "2"^^ . . . _:b446364099 . _:b446363042 "2"^^ . . _:b446363053 "2"^^ . _:b446364098 . . . _:b446361014 . . _:b446364109 . _:b446363052 "2"^^ . . _:b446363055 "2"^^ . _:b446364108 . . _:b446364111 . _:b446363054 "2"^^ . . _:b446362542 . _:b446363049 "2"^^ . _:b446364110 . _:b446363048 "2"^^ . _:b446364105 . _:b446363309 . _:b446363397 . _:b446363051 "2"^^ . _:b446364104 . _:b446363651 . _:b446364391 . . _:b446363050 "2"^^ . _:b446364107 . . _:b446363061 "2"^^ . _:b446364106 . . . . _:b446364117 . _:b446363060 "2"^^ . _:b446362015 . _:b446364116 . _:b446363063 "2"^^ . . . _:b446364119 . _:b446363062 "2"^^ . _:b446363057 "2"^^ . _:b446364118 . _:b446363056 "2"^^ . _:b446364113 . _:b446362198 . _:b446363059 "2"^^ . _:b446364112 . _:b446363058 "2"^^ . _:b446364115 . _:b446361056 . _:b446364114 . _:b446363069 "2"^^ . _:b446363068 "2"^^ . _:b446364125 . _:b446363071 "2"^^ . _:b446364333 . _:b446364124 . . _:b446363070 "2"^^ . _:b446364127 . . _:b446363065 "2"^^ . _:b446364126 . _:b446362355 . _:b446363064 "2"^^ . _:b446364121 . . _:b446364486 . _:b446363067 "2"^^ . _:b446364120 . . _:b446363066 "2"^^ . _:b446364123 . _:b446363077 "2"^^ . _:b446364122 . . _:b446363076 "2"^^ . _:b446364133 . _:b446361099 . _:b446363079 "2"^^ . _:b446364132 . _:b446361281 . _:b446362201 . _:b446364135 . _:b446363078 "2"^^ . . _:b446363073 "2"^^ . _:b446364134 . . . _:b446364129 . _:b446363072 "2"^^ . . . _:b446364128 . _:b446363075 "2"^^ . _:b446363074 "2"^^ . _:b446364131 . _:b446361982 . _:b446360928 . _:b446363085 "2"^^ . _:b446364130 . . _:b446364143 . _:b446363084 "2"^^ . _:b446364141 . . _:b446363087 "2"^^ . _:b446364140 . . _:b446363086 "2"^^ . _:b446364143 . . _:b446363081 "2"^^ . _:b446364142 . _:b446361461 . _:b446363080 "2"^^ . _:b446364137 . . _:b446364136 . _:b446363592 . _:b446363083 "2"^^ . _:b446363082 "2"^^ . _:b446364139 . _:b446363093 "2"^^ . _:b446364138 . _:b446363092 "2"^^ . _:b446364149 . _:b446363095 "2"^^ . _:b446364148 . _:b446363273 . _:b446362498 . _:b446362130 . _:b446363094 "2"^^ . _:b446364277 . _:b446364151 . _:b446364086 . _:b446363089 "2"^^ . _:b446364150 . _:b446363088 "2"^^ . _:b446364145 . _:b446363091 "2"^^ . _:b446364144 . . _:b446363090 "2"^^ . _:b446364147 . _:b446363166 . _:b446363101 "2"^^ . _:b446364146 . _:b446363100 "2"^^ . _:b446364157 . . _:b446363103 "2"^^ . _:b446364156 . _:b446364356 . _:b446362747 . _:b446361349 . _:b446363102 "2"^^ . _:b446364159 . _:b446363235 . _:b446363528 . _:b446363097 "2"^^ . _:b446364158 . _:b446361776 . . _:b446364153 . _:b446363096 "2"^^ . _:b446361728 . _:b446363297 . _:b446363421 . _:b446363099 "2"^^ . _:b446364152 . . _:b446364155 . _:b446363098 "2"^^ . _:b446362124 . . _:b446364154 . _:b446363109 "2"^^ . . _:b446363108 "2"^^ . _:b446363653 . . . _:b446363111 "2"^^ . _:b446363652 . . _:b446363655 . _:b446363110 "2"^^ . . _:b446363506 . _:b446363105 "2"^^ . _:b446363654 . . . _:b446363649 . _:b446363557 . _:b446363104 "2"^^ . _:b446362088 . . . _:b446363107 "2"^^ . _:b446363648 . . _:b446363651 . _:b446363106 "2"^^ . . _:b446360950 . _:b446363117 "2"^^ . _:b446363650 . _:b446363130 . . . _:b446363116 "2"^^ . _:b446363661 . . . _:b446363119 "2"^^ . _:b446363660 . _:b446361994 . _:b446362583 . _:b446363118 "2"^^ . _:b446363663 . _:b446363113 "2"^^ . _:b446363662 . . _:b446363657 . _:b446363112 "2"^^ . . _:b446361217 . . _:b446363081 . _:b446363656 . _:b446363115 "2"^^ . _:b446364416 . _:b446363114 "2"^^ . _:b446363659 . . _:b446363263 . _:b446363125 "2"^^ . _:b446363658 . . . _:b446363124 "2"^^ . _:b446363669 . . . _:b446363668 . _:b446363127 "2"^^ . _:b446364304 . _:b446363126 "2"^^ . _:b446363671 . _:b446362319 . _:b446363121 "2"^^ . _:b446363670 . _:b446362421 . . _:b446363665 . _:b446363120 "2"^^ . _:b446362268 . . _:b446363895 . . _:b446363123 "2"^^ . _:b446363664 . . _:b446361225 . . _:b446363122 "2"^^ . _:b446364125 . _:b446363667 . . _:b446363133 "2"^^ . _:b446363666 . _:b446363132 "2"^^ . _:b446363677 . _:b446362657 . _:b446363135 "2"^^ . _:b446363676 . _:b446363134 "2"^^ . _:b446363679 . _:b446361693 . _:b446363129 "2"^^ . _:b446363678 . _:b446363514 . _:b446363128 "2"^^ . _:b446363673 . _:b446363131 "2"^^ . _:b446363672 . _:b446363130 "2"^^ . _:b446363675 . _:b446363674 . _:b446362117 "3"^^ . _:b446363685 . _:b446362116 "3"^^ . . . _:b446363684 . . _:b446362119 "3"^^ . . _:b446362491 . _:b446363687 . . _:b446362118 "3"^^ . . _:b446363686 . _:b446362113 "3"^^ . . _:b446363681 . _:b446362112 "3"^^ . . _:b446363680 . _:b446362115 "3"^^ . _:b446363683 . _:b446362114 "3"^^ . _:b446362080 . _:b446363682 . _:b446362125 "3"^^ . . . _:b446363693 . _:b446362124 "3"^^ . _:b446362889 . . . _:b446363400 . _:b446363692 . _:b446362127 "3"^^ . _:b446363663 . _:b446363695 . _:b446362126 "3"^^ . _:b446363694 . _:b446362121 "3"^^ . _:b446363689 . _:b446362120 "3"^^ . . _:b446363688 . _:b446363488 . . _:b446362306 . _:b446361356 . _:b446362200 . _:b446362123 "3"^^ . . . _:b446363691 . . _:b9113980 "As the great majority of mutations identified in cancers are believed to be passengers, the results of the model are not highly dependent on the model used to estimate the relatively small number of drivers >>16<<." . _:b446362122 "3"^^ . _:b446361579 . _:b446363690 . _:b446362133 "3"^^ . . _:b446363701 . _:b446362132 "3"^^ . _:b446361757 . _:b446363700 . _:b446362135 "3"^^ . . _:b446363703 . _:b446362134 "3"^^ . _:b446363702 . _:b446362129 "3"^^ . _:b446362757 . _:b446363697 . _:b446362128 "3"^^ . _:b446361311 . _:b446361234 . _:b446363696 . _:b446362131 "3"^^ . . _:b446363699 . _:b446363876 . _:b446362130 "3"^^ . . _:b446361146 . . _:b446362551 . _:b446363698 . _:b446362141 "3"^^ . _:b446363709 . _:b446362140 "3"^^ . _:b446363702 . _:b446363708 . _:b446362143 "3"^^ . _:b446362576 . _:b446363711 . _:b446362142 "3"^^ . _:b446363710 . _:b446362137 "3"^^ . _:b446362772 . . _:b446361980 . _:b446363705 . _:b446361359 . _:b446362136 "3"^^ . _:b446364331 . _:b446363704 . _:b446362139 "3"^^ . _:b446363707 . _:b446362138 "3"^^ . _:b446363706 . _:b446362149 "3"^^ . . _:b446363717 . _:b446362168 . _:b446362148 "3"^^ . . _:b446363716 . _:b446363896 . _:b446362151 "3"^^ . _:b446362710 . . _:b446363719 . . _:b446362150 "3"^^ . _:b446362606 . _:b446363718 . . _:b446364269 . _:b446362145 "3"^^ . _:b446363713 . _:b446364501 . . _:b446362144 "3"^^ . _:b446361064 . _:b446362591 . _:b446363712 . _:b446362147 "3"^^ . . _:b446363715 . _:b446363674 . _:b446362146 "3"^^ . . _:b446363714 . _:b446362157 "3"^^ . _:b446362055 . _:b446363725 . _:b446362133 . _:b446362156 "3"^^ . _:b446363724 . _:b446362159 "3"^^ . _:b446363727 . _:b446362158 "3"^^ . _:b446363624 . _:b446361218 . _:b446363726 . _:b446362153 "3"^^ . _:b446363967 . _:b446363709 . _:b446363721 . _:b446361055 . _:b446362152 "3"^^ . _:b446363662 . . . _:b446362724 . _:b446363720 . _:b446362155 "3"^^ . . . _:b446363723 . _:b446362154 "3"^^ . . _:b446363722 . _:b446360993 . _:b446362165 "3"^^ . . _:b446360861 . _:b446363733 . _:b446362164 "3"^^ . _:b446364588 . . _:b446363732 . _:b446362167 "3"^^ . . . _:b446361113 . _:b446363735 . _:b446362166 "3"^^ . . _:b446363734 . _:b446362161 "3"^^ . _:b446363729 . _:b446362160 "3"^^ . . _:b446363728 . _:b446362163 "3"^^ . _:b446363731 . _:b446362162 "3"^^ . _:b446363730 . _:b446363936 . _:b446362173 "3"^^ . _:b446362338 . _:b446363741 . _:b446362172 "3"^^ . . _:b446363740 . _:b446362175 "3"^^ . _:b446363743 . . _:b446362174 "3"^^ . . _:b446361606 . _:b446363742 . _:b446364348 . _:b446362169 "3"^^ . . _:b446363737 . _:b446362168 "3"^^ . _:b446362967 . _:b446363736 . _:b446362171 "3"^^ . _:b446363739 . . _:b446363057 . _:b446362170 "3"^^ . _:b446362101 . . . _:b446363738 . _:b446362181 "3"^^ . _:b446361034 . _:b446363749 . _:b446362180 "3"^^ . _:b446363748 . _:b446362183 "3"^^ . . _:b446363751 . _:b446362182 "3"^^ . _:b446363750 . _:b446362177 "3"^^ . . _:b446363745 . _:b446362176 "3"^^ . _:b446363744 . _:b446362179 "3"^^ . _:b446361161 . _:b446363747 . . _:b446362178 "3"^^ . . . . _:b446361355 . _:b446363746 . _:b446362189 "3"^^ . _:b446363970 . _:b446363757 . _:b446362188 "3"^^ . . _:b446363756 . . _:b446362191 "3"^^ . . _:b446363759 . _:b446361913 . _:b446362190 "3"^^ . _:b446360913 . _:b446363758 . _:b446361290 . _:b446362185 "3"^^ . _:b446363753 . _:b446362184 "3"^^ . _:b446361641 . . _:b446363752 . _:b446361769 . _:b446362187 "3"^^ . _:b446363755 . _:b446362186 "3"^^ . _:b446363754 . _:b446362197 "3"^^ . _:b446363638 . _:b446363765 . . _:b446362196 "3"^^ . . . _:b446363764 . . . _:b446362199 "3"^^ . _:b446363767 . _:b446362198 "3"^^ . . _:b446363766 . _:b446362193 "3"^^ . . _:b446361268 . _:b446363761 . . _:b446362192 "3"^^ . _:b446362291 . _:b446363760 . . _:b446362195 "3"^^ . _:b446363763 . _:b446362194 "3"^^ . _:b446360870 . _:b446363762 . _:b446362205 "3"^^ . _:b446363543 . _:b446363773 . _:b446362204 "3"^^ . _:b446363772 . . _:b446362207 "3"^^ . _:b446363775 . _:b446362206 "3"^^ . _:b446361953 . _:b446363774 . _:b446363367 . _:b446362201 "3"^^ . _:b446363867 . . _:b446363769 . . _:b446362200 "3"^^ . . _:b446363768 . _:b446362203 "3"^^ . _:b446362742 . _:b446363925 . _:b446364593 . _:b446363771 . _:b446362202 "3"^^ . _:b446362697 . . . _:b446363770 . _:b446362213 "3"^^ . _:b446363667 . _:b446363781 . _:b446362212 "3"^^ . . _:b446363780 . _:b446362215 "3"^^ . _:b446363783 . _:b446362214 "3"^^ . _:b446363782 . _:b446362209 "3"^^ . . _:b446363777 . . _:b446362208 "3"^^ . _:b446362596 . _:b446363776 . . _:b446362211 "3"^^ . . . _:b446361709 . _:b446363779 . . _:b446362210 "3"^^ . . . . _:b446363778 . . _:b446362221 "3"^^ . . . _:b446363789 . _:b446364078 . _:b446362220 "3"^^ . _:b446363619 . _:b446363788 . _:b446362223 "3"^^ . _:b446362999 . _:b446363258 . . _:b446363791 . . _:b446364310 . _:b446362222 "3"^^ . _:b446363790 . _:b446362217 "3"^^ . _:b446363785 . _:b446362216 "3"^^ . . _:b446363784 . _:b446362219 "3"^^ . _:b446363675 . _:b446363312 . _:b446363787 . . _:b446362218 "3"^^ . _:b446363786 . _:b446362229 "3"^^ . . _:b446363797 . _:b446362228 "3"^^ . _:b446363796 . _:b446364206 . _:b446362231 "3"^^ . . . _:b446363799 . . _:b446362230 "3"^^ . . _:b446363798 . _:b446364636 . _:b446362225 "3"^^ . _:b446363793 . _:b446362224 "3"^^ . _:b446363792 . _:b446362227 "3"^^ . . _:b446363795 . _:b446362226 "3"^^ . _:b446364200 . _:b446361132 . _:b446363794 . _:b446362237 "3"^^ . . _:b446363805 . _:b446362236 "3"^^ . _:b446363804 . . _:b446362239 "3"^^ . _:b446363807 . _:b446362238 "3"^^ . . _:b446363806 . _:b446362233 "3"^^ . _:b446363388 . _:b446360944 . _:b446363801 . _:b446362232 "3"^^ . . _:b446361201 . _:b446361949 . _:b446363856 . . _:b446363800 . . _:b446362235 "3"^^ . _:b446363461 . . _:b446363803 . _:b446362234 "3"^^ . . _:b446363802 . _:b446362245 "3"^^ . _:b446363813 . . _:b446362244 "3"^^ . . _:b446363812 . _:b446361564 . _:b446362589 . _:b446362247 "3"^^ . _:b446363815 . _:b446362246 "3"^^ . . _:b446363814 . _:b446363971 . _:b446362241 "3"^^ . _:b446363809 . _:b446362240 "3"^^ . . _:b446363808 . _:b446362243 "3"^^ . _:b446363811 . _:b446362242 "3"^^ . _:b446360955 . . _:b446363810 . _:b446362253 "3"^^ . _:b446364296 . _:b446363821 . _:b446362252 "3"^^ . _:b446363820 . _:b446362255 "3"^^ . _:b446363823 . _:b446362254 "3"^^ . _:b446362376 . _:b446363822 . _:b446362249 "3"^^ . _:b446363255 . . _:b446361236 . _:b446363817 . . _:b446362248 "3"^^ . . _:b446363938 . . _:b446363816 . _:b446362251 "3"^^ . _:b446363819 . . _:b446362250 "3"^^ . _:b446363818 . _:b446362261 "3"^^ . . _:b446363829 . _:b446362260 "3"^^ . _:b446363828 . _:b446362263 "3"^^ . _:b446363831 . _:b446362262 "3"^^ . . _:b446363830 . _:b446362257 "3"^^ . _:b446363825 . _:b446364543 . _:b446362256 "3"^^ . _:b446363824 . _:b446362259 "3"^^ . _:b446363827 . _:b446362258 "3"^^ . _:b446362904 . _:b446363826 . _:b446362269 "3"^^ . _:b446363837 . . . _:b446362268 "3"^^ . _:b446363836 . _:b446362271 "3"^^ . . _:b446364122 . _:b446363839 . _:b446362270 "3"^^ . _:b446363838 . . _:b446362265 "3"^^ . _:b446363833 . . _:b446362264 "3"^^ . _:b446361036 . _:b446364448 . _:b446363832 . _:b446362267 "3"^^ . _:b446363993 . _:b446363835 . _:b446362266 "3"^^ . _:b446362552 . . _:b446363834 . _:b446362277 "3"^^ . . . _:b446363845 . _:b446362276 "3"^^ . . _:b446362855 . _:b446363844 . _:b446362279 "3"^^ . _:b446364229 . . _:b446363847 . _:b446362278 "3"^^ . _:b446363846 . _:b446362273 "3"^^ . _:b446363841 . _:b446362272 "3"^^ . _:b446363840 . _:b446362275 "3"^^ . . _:b446363843 . _:b446362274 "3"^^ . _:b446361653 . _:b446363767 . . _:b446363842 . _:b446360849 . _:b446362285 "3"^^ . . _:b446363853 . _:b446362284 "3"^^ . . _:b446363852 . _:b446362287 "3"^^ . _:b446363855 . _:b446362286 "3"^^ . _:b446363854 . _:b446362281 "3"^^ . _:b446363849 . _:b446362280 "3"^^ . _:b446363707 . _:b446363848 . _:b446364645 . _:b446362283 "3"^^ . _:b446363851 . _:b446362282 "3"^^ . . _:b446363850 . _:b446362293 "3"^^ . _:b446361213 . _:b446363861 . _:b446362292 "3"^^ . _:b446364553 . . . _:b446363860 . _:b446362295 "3"^^ . _:b446364502 . . _:b446363863 . _:b446362294 "3"^^ . . _:b446363862 . . _:b446362289 "3"^^ . . _:b446363857 . _:b446362288 "3"^^ . . _:b446364542 . . _:b446363856 . . _:b446362291 "3"^^ . _:b446363859 . _:b446362290 "3"^^ . . _:b446363858 . _:b446362301 "3"^^ . . _:b446363982 . _:b446363551 . _:b446364111 . _:b446363869 . . _:b446362300 "3"^^ . . _:b446363868 . _:b446362303 "3"^^ . . _:b446363871 . _:b446361078 . _:b446362956 . _:b446362302 "3"^^ . _:b446363870 . _:b446362297 "3"^^ . . _:b446363865 . _:b446362296 "3"^^ . . _:b446363864 . _:b446362299 "3"^^ . _:b446363867 . _:b446362298 "3"^^ . _:b446362679 . _:b446361694 . _:b446363866 . _:b446363902 . _:b446362309 "3"^^ . _:b446364615 . . _:b446363877 . _:b446362308 "3"^^ . . _:b446363747 . _:b446363736 . _:b446363876 . _:b446362311 "3"^^ . . _:b446364219 . _:b446363879 . . _:b446362310 "3"^^ . . _:b446363878 . . _:b446364603 . _:b446362985 . _:b446362305 "3"^^ . . _:b446363873 . _:b446362304 "3"^^ . _:b446363872 . _:b446362307 "3"^^ . _:b446363875 . _:b446362306 "3"^^ . _:b446363866 . _:b446363874 . _:b446362317 "3"^^ . _:b446363885 . _:b446362316 "3"^^ . . _:b446363884 . _:b446361462 . _:b446362319 "3"^^ . . _:b446363887 . . _:b446362318 "3"^^ . _:b446361897 . . _:b446363886 . _:b446362313 "3"^^ . . _:b446362075 . _:b446363881 . _:b446362312 "3"^^ . _:b446363182 . . _:b446363880 . _:b446362315 "3"^^ . . _:b446363883 . . _:b446362314 "3"^^ . _:b446362581 . _:b446363882 . _:b446362325 "3"^^ . _:b446363893 . _:b446361549 . _:b446362324 "3"^^ . . _:b446363892 . _:b446362327 "3"^^ . . . _:b446363895 . . _:b446362095 . _:b446362326 "3"^^ . . . _:b446363894 . _:b446362321 "3"^^ . _:b446363478 . _:b446363889 . _:b446362320 "3"^^ . . _:b446363888 . . _:b446362323 "3"^^ . . . _:b446363891 . _:b446362322 "3"^^ . _:b446362707 . _:b446363890 . _:b446362333 "3"^^ . _:b446363901 . _:b446362332 "3"^^ . _:b446363940 . _:b446363900 . . _:b446362390 . _:b446362335 "3"^^ . _:b446363903 . _:b446362334 "3"^^ . . _:b446362812 . _:b446363902 . _:b446362329 "3"^^ . . _:b446363897 . _:b446362281 . _:b446362328 "3"^^ . _:b446363097 . . _:b446363896 . _:b446362331 "3"^^ . . _:b446363899 . _:b446362817 . _:b446362330 "3"^^ . _:b446364285 . _:b446363898 . _:b446362341 "3"^^ . . _:b446362340 "3"^^ . _:b446364630 . _:b446362343 "3"^^ . _:b446361453 . _:b446361546 . _:b446362342 "3"^^ . . _:b446363772 . _:b446362337 "3"^^ . . . _:b446362336 "3"^^ . _:b446362940 . . . . _:b446363798 . _:b446362339 "3"^^ . . . _:b446362338 "3"^^ . _:b446363843 . . . _:b446364400 . _:b446362349 "3"^^ . . _:b446362785 . _:b446361279 . . _:b446362348 "3"^^ . . _:b446362351 "3"^^ . . . _:b446363261 . . . _:b446361912 . _:b446362350 "3"^^ . _:b446363085 . _:b446362071 . _:b446362345 "3"^^ . _:b446362156 . . _:b446362344 "3"^^ . . _:b446360966 . _:b446362347 "3"^^ . _:b446364007 . _:b446362346 "3"^^ . _:b446362357 "3"^^ . _:b446362356 "3"^^ . _:b446361952 . _:b446361930 . _:b446362359 "3"^^ . . _:b446363910 . _:b446362358 "3"^^ . . _:b446364157 . _:b446362353 "3"^^ . _:b446363496 . _:b446362352 "3"^^ . . _:b446362355 "3"^^ . _:b446364600 . _:b446362354 "3"^^ . . _:b446362365 "3"^^ . . _:b446362364 "3"^^ . _:b446362687 . _:b446361223 . _:b446363268 . _:b446362367 "3"^^ . _:b446361812 . _:b446362366 "3"^^ . . _:b446362361 "3"^^ . _:b446362360 "3"^^ . _:b446361734 . _:b446362766 . _:b446364105 . _:b446362363 "3"^^ . . . _:b446362362 "3"^^ . . _:b446362373 "3"^^ . _:b446362465 . _:b446361439 . _:b446362372 "3"^^ . . _:b446362375 "3"^^ . . _:b446361831 . _:b446362374 "3"^^ . . _:b446362369 "3"^^ . _:b446362154 . _:b446362368 "3"^^ . . _:b446364032 . . . _:b446362371 "3"^^ . _:b446362370 "3"^^ . _:b446363437 . . _:b446362381 "3"^^ . _:b446363069 . . . . _:b446362380 "3"^^ . _:b446362383 "3"^^ . . _:b446362382 "3"^^ . . _:b446362377 "3"^^ . _:b446364312 . _:b446361070 . _:b446361966 . . _:b446362376 "3"^^ . _:b446361775 . . _:b446362379 "3"^^ . _:b446364297 . _:b446363088 . _:b446362378 "3"^^ . . . _:b446362389 "3"^^ . _:b446363846 . . _:b446361061 . _:b446362388 "3"^^ . _:b446362304 . _:b446362391 "3"^^ . . _:b446362390 "3"^^ . _:b446362385 "3"^^ . . _:b446363363 . _:b446362384 "3"^^ . _:b446361651 . _:b446362387 "3"^^ . . _:b446362386 "3"^^ . _:b446362397 "3"^^ . _:b446362396 "3"^^ . _:b446362777 . _:b446362399 "3"^^ . _:b446362398 "3"^^ . . _:b446362393 "3"^^ . . _:b446362392 "3"^^ . _:b446362395 "3"^^ . _:b446362394 "3"^^ . _:b446364596 . _:b446362405 "3"^^ . _:b446362404 "3"^^ . . . _:b446363181 . . _:b446364223 . _:b446362407 "3"^^ . . . _:b446362406 "3"^^ . _:b446362401 "3"^^ . _:b446362736 . _:b446362400 "3"^^ . _:b446362403 "3"^^ . _:b446362402 "3"^^ . . _:b446362413 "3"^^ . _:b446362131 . . _:b446362412 "3"^^ . _:b446361418 . _:b446362415 "3"^^ . _:b446363108 . . _:b446362414 "3"^^ . . . _:b446364362 . _:b446362409 "3"^^ . . _:b446361561 . _:b446362408 "3"^^ . _:b446362411 "3"^^ . . _:b446360960 . _:b446362410 "3"^^ . . _:b446363003 . _:b446362179 . _:b446362421 "3"^^ . _:b446362420 "3"^^ . _:b446362423 "3"^^ . _:b446364614 . . _:b446362422 "3"^^ . _:b446362417 "3"^^ . . . _:b446363734 . . _:b446362416 "3"^^ . . _:b446363254 . . _:b446362419 "3"^^ . _:b446364013 . _:b446362418 "3"^^ . . . _:b446361028 . _:b446362717 . _:b446362429 "3"^^ . _:b446362428 "3"^^ . _:b446363788 . . _:b446362431 "3"^^ . _:b446362430 "3"^^ . _:b446362425 "3"^^ . _:b446362424 "3"^^ . . _:b446362081 . _:b446362427 "3"^^ . _:b446361862 . _:b446362426 "3"^^ . _:b446363430 . _:b446363579 . _:b446361415 . _:b446363112 . _:b446362437 "3"^^ . . _:b446362436 "3"^^ . . _:b446362439 "3"^^ . _:b446363559 . _:b446362438 "3"^^ . . _:b446362433 "3"^^ . . _:b446362432 "3"^^ . . _:b446362984 . _:b446362435 "3"^^ . . _:b446362434 "3"^^ . _:b446362445 "3"^^ . . _:b446362444 "3"^^ . _:b446362117 . _:b446362447 "3"^^ . . _:b446362446 "3"^^ . . . _:b446361778 . _:b446362441 "3"^^ . _:b446362440 "3"^^ . . _:b446362443 "3"^^ . . _:b446363286 . _:b446362442 "3"^^ . . _:b446361059 . _:b446364255 . _:b446362453 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