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bibo:doi: 10.1038%2Fng.796
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Subject Item: _:vb10568059
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dc:title: methods
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Subject Item: _:vb10568060
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rdf:value: A 9.8kb was retrieved from BAC bMQ-282D14 using oligonucleotide recombineering>>29<< and modified to the Npm1flox-cA targeting construct (duplicated region: NCBIM37-chr11:
n2:mentions: n3:12618378

Subject Item: _:vb10568061
rdf:type: n2:Context
rdf:value: Npm1cA (Post-Cre) ES cell clones were derived under FIAU selection>>30<<. Npm1flox-cA/+ and Npm1flox-cA/flox-cA mice were crossed with Stella-Cre for embryonic viability and Mx1-Cre31 mice for hemopoietic studies.
n2:mentions: n3:11020714

Subject Item: _:vb10568062
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rdf:value: Npm1flox-cA/+ and Npm1flox-cA/flox-cA mice were crossed with Stella-Cre for embryonic viability and Mx1-Cre>>31<< mice for hemopoietic studies.
n2:mentions: n3:7660125

Subject Item: _:vb10568063
rdf:type: n2:Context
rdf:value: Mouse femurs and spleens were processed as described>>32<<. For BM lineage analysis we stained with Gr1-PE and CD11b(Mac1)-FITC, or B220-APC-Alexa750 and CD19-PE.
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Subject Item: _:vb10568064
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rdf:value: Data were quantile normalised>>33<< and analyzed using the bioconductor (http://www.
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Subject Item: _:vb10568065
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rdf:value: BM or spleen cells were plated in M3434 (Stem Cell Technologies) as described>>33<<. Colonies were counted/picked after 10-12 days. For re-plating assays 50,000 BM cells from 6xNpm1cA/+ and 6xNpm1WT mice were plated and counted after 8 days with 30,000 cells re-plated etc.
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Subject Item: _:vb10568066
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rdf:value: These were done as described>>36<< using SB-specific primers and 454-sequenced.
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Subject Item: _:vb10568067
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rdf:value: To identify CISs, non-redundant insertions were analyzed using a Gaussian Kernel Convolution-based framework>>37<< for 10Kb, 30Kb, 60Kb and 120Kb windows and all windows merged to compile CIS lists38.
n2:mentions: n3:17154714

Subject Item: _:vb10568068
rdf:type: n2:Context
rdf:value: To identify CISs, non-redundant insertions were analyzed using a Gaussian Kernel Convolution-based framework37 for 10Kb, 30Kb, 60Kb and 120Kb windows and all windows merged to compile CIS lists>>38<<. To identify previously described CISs we searched the retroviral tagged cancer gene database (RTCGD, http://rtcgd.ncifcrf.gov)36 and recent insertional mutagenesis publications3-4,39-40.
n2:mentions: n3:14681473

Subject Item: _:vb10568069
rdf:type: n2:Context
rdf:value: To identify previously described CISs we searched the retroviral tagged cancer gene database (RTCGD, http://rtcgd.ncifcrf.gov)>>36<< and recent insertional mutagenesis publications3-4,39-40.
n2:mentions: n3:19528954

Subject Item: _:vb10568070
rdf:type: n2:Context
rdf:value: To identify previously described CISs we searched the retroviral tagged cancer gene database (RTCGD, http://rtcgd.ncifcrf.gov)36 and recent insertional mutagenesis publications>>3<<-4,39-40.
n2:mentions: n3:16015321 n3:16015333

Subject Item: _:vb10568071
rdf:type: n2:Context
rdf:value: To identify previously described CISs we searched the retroviral tagged cancer gene database (RTCGD, http://rtcgd.ncifcrf.gov)36 and recent insertional mutagenesis publications3-4,>>39<<-40.
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