_:b482083422 . . _:b482083417 . . . _:b482083416 . . _:b482083419 . _:b482086419 . _:b482084141 . _:b482083418 . _:b482085900 . _:b482083429 . _:b482085978 . _:b482084650 . _:b482083180 . _:b482083428 . . _:b482083431 . . . _:b482083430 . . _:b482083425 . _:b482083424 . . _:b482083427 . _:b482083426 . _:b482083437 . . . _:b482084979 . _:b482083436 . _:b482084561 . _:b482083439 . _:b482084706 . _:b482083629 . . _:b482083438 . . . _:b482083433 . _:b482083432 . _:b482083435 . . . . _:b482085475 . _:b482083434 . _:b482083445 . _:b482085175 . _:b482083444 . _:b482085583 . _:b482084702 . _:b482083447 . . _:b482084277 . _:b482083446 . _:b482084145 . _:b14077284 "results" . _:b482083441 . . _:b482083440 . _:b482083443 . . _:b482083442 . _:b482083748 . _:b482085142 . _:b482083453 . _:b482086251 . . _:b482084894 . . _:b482086317 . _:b482083452 . _:b482084041 . . _:b482085737 . _:b482083455 . _:b482083454 . _:b482083449 . _:b482083448 . . _:b482083451 . . _:b482084169 . _:b482083450 . . _:b482083461 . _:b482084648 . _:b482083460 . _:b482084548 . _:b482083463 . _:b482085159 . . _:b482083462 . _:b482085878 . _:b482083457 . _:b482083456 . _:b14077308 "ALL patients using FISH and/or copy number alterations detected by SNP arrays, and it enhances the understanding of genetic changes acquired during disease progression, as previously described for breast and pancreatic cancer metastases >>22<<\u201325. Our data provide complementary information on clonal evolution in AML, using a much larger set of mutations that were quantified with deep sequencing; this provides an unprecedented number of events that can be used to precisely" . _:b482083459 . _:b482084784 . _:b482083458 . _:b482085176 . _:b482083469 . . _:b482083468 . _:b482086066 . _:b482085594 . _:b482083630 . _:b482083471 . _:b482083470 . . _:b482083465 . _:b482083464 . _:b482086011 . _:b482083467 . . . _:b482083466 . _:b482083477 . . . _:b482083476 . _:b482083479 . _:b482083977 . _:b482083478 . _:b482083473 . . _:b482083472 . _:b482084188 . _:b482083475 . _:b482083474 . _:b482083786 . _:b482083485 . _:b482083484 . _:b482084826 . _:b482083487 . . _:b482083779 . _:b482083486 . _:b482085229 . _:b482083481 . _:b482085379 . _:b482083480 . . _:b482083483 . _:b482083499 . _:b482083482 . . . _:b482083493 . . _:b482086546 . . . _:b482083492 . _:b482084902 . _:b482084662 . . _:b482083495 . . _:b482083494 . . _:b482084699 . _:b482083371 . _:b482083489 . . _:b482084900 . _:b482083488 . _:b482085744 . . _:b482083491 . _:b482086061 . _:b482083490 . . _:b482083501 . _:b482084354 . _:b482083500 . . _:b482083503 . _:b482084222 . _:b482084518 . _:b482083502 . _:b482083497 . . _:b482083496 . _:b482083499 . . _:b482083498 . _:b482084670 . _:b482083509 . _:b482083508 . _:b482086296 . _:b482083511 . _:b482083510 . _:b482083505 . _:b482085552 . _:b482084385 . _:b482083504 . . _:b482083507 . . _:b482084847 . _:b482083506 . . _:b482083517 . _:b482085827 . _:b482084128 . _:b482083516 . . _:b482083519 . _:b482083518 . _:b482085223 . _:b482083513 . _:b482084418 . . _:b482083512 . _:b482083559 . _:b482084485 . _:b482083515 . . _:b482083943 . _:b482083514 . _:b482083525 . _:b482083524 . _:b482084653 . _:b482083527 . . _:b482083526 . _:b482083894 . _:b482083521 . _:b482083520 . _:b482083523 . . _:b482083522 . _:b482086136 . _:b482083533 . _:b482083587 . _:b482083532 . _:b482083233 . _:b482085136 . . _:b482083535 . . . . _:b482083534 . _:b482085657 . _:b482085729 . _:b482084840 . _:b482083529 . _:b482083528 . _:b482084082 . _:b482083531 . _:b482083530 . _:b482084922 . _:b482083541 . _:b482085948 . _:b482086431 . _:b482086501 . _:b482083540 . _:b482083543 . _:b482084520 . _:b482083542 . . _:b482083537 . _:b482084471 . _:b482084187 . _:b482083536 . . _:b482083539 . _:b482085415 . _:b482083538 . _:b482083549 . . _:b482083548 . _:b482084812 . _:b482083551 . . _:b482083550 . . _:b482083545 . . _:b482084677 . _:b482083544 . _:b482086047 . . _:b482085241 . _:b482083547 . . _:b482083546 . . _:b482084317 . _:b482083557 . . . _:b482083556 . _:b482084333 . _:b482085597 . _:b482083559 . . . _:b482083558 . _:b482086440 . _:b482083553 . _:b482083552 . _:b482083879 . . . . _:b482083555 . _:b482086358 . _:b482083826 . _:b482083554 . . _:b482083565 . _:b482085855 . _:b482083564 . . _:b482083567 . . . _:b482083566 . . . _:b482086410 . _:b482083561 . _:b482083560 . _:b482085663 . _:b482086338 . . _:b482083368 . _:b482083563 . _:b482083562 . _:b482083573 . . _:b482083572 . _:b482083575 . _:b482083574 . _:b482083569 . . _:b482083510 . . _:b482083568 . _:b482083571 . . . . _:b482083570 . _:b482083581 . _:b482083580 . _:b482083583 . _:b482083582 . . _:b482085899 . _:b482083577 . _:b482083576 . . . _:b482083429 . _:b482083579 . _:b482083578 . _:b482083976 . _:b482083990 . _:b482084226 . _:b482085255 . . . . _:b482086326 . . . . _:b482086544 . . . _:b482083259 . . _:b482084076 . _:b482083783 . _:b482085152 . . . _:b482084631 . . _:b482085591 . _:b482083763 . _:b482084338 . . _:b482084207 . _:b482083207 . _:b482084259 . . . _:b14077295 . . _:b482085348 . . _:b482086109 . . . _:b482083540 . _:b14077288 "In addition to the ten somatic nonsynonymous mutations originally reported for the primary tumor sample>>3<<, we identified one deletion that was not detected in the original analysis (DNMT3A L723fs8) and three missense mutations previously misclassified as germline events (SMC3 G662C, PDXDC1 E421K, and TTN E14263K) (Fig." . _:b482084444 . . _:b482084834 . _:b482084717 . _:b482086080 . _:b482083276 . _:b482085092 . _:b482083407 . . _:b482083958 . _:b482086261 . _:b482083280 . _:b482085866 . . . . . . _:b482085078 . _:b482083800 . _:b482085888 . _:b482086255 . _:b482085444 . . . _:b482084382 . . . . . . . . _:b482085941 . . . . _:b482084652 . . . . . _:b482084389 . . . . . _:b482083841 . . . . . . . . . _:b482085533 . . . _:b482084247 . . . . . _:b482084737 . _:b482083344 . . . . _:b482084302 . . . _:b482084433 . . _:b482086319 . . _:b482086434 . _:b482086178 . . _:b482084249 . . _:b482084911 . . _:b482085505 . _:b482083684 . _:b482084626 . . . . . _:b482084777 . . . _:b482086522 . . _:b482085359 . _:b482083417 . . _:b482085944 . . _:b482084691 . . . _:b482085740 . _:b482084152 . _:b482083572 . _:b482085432 . _:b482085289 . . _:b482083187 . . . . . . _:b482083934 . . _:b482084180 . _:b482085667 . . _:b482083181 . _:b482083180 . . _:b482083183 . . _:b482083182 . _:b482085192 . . _:b482086398 . _:b482083179 . _:b482086023 . . _:b482083189 . . _:b482086094 . . _:b482083188 . . _:b482083191 . _:b482083190 . _:b482084820 . _:b482083989 . _:b482083185 . . . _:b482083219 . . _:b482083184 . . _:b482084560 . _:b482083187 . . . _:b482083186 . _:b482083197 . _:b482086071 . _:b482084977 . _:b482083196 . _:b482083504 . _:b482083199 . . _:b482083198 . _:b482083193 . . _:b482083576 . _:b482083192 . . _:b482083933 . _:b482083195 . . . . _:b482083194 . _:b482084012 . _:b482083836 . _:b482083205 . _:b482083204 . . . _:b482083207 . _:b482083206 . . _:b482083201 . . . _:b482083200 . . _:b482085127 . _:b482083456 . _:b482083203 . . _:b482083202 . _:b482084535 . _:b482083213 . _:b482085030 . _:b482083863 . _:b482085273 . _:b482084792 . _:b482083212 . _:b482084138 . _:b482083215 . _:b482085947 . _:b482083214 . _:b482083209 . _:b482086394 . . _:b482083208 . _:b482083927 . _:b482085558 . _:b482083211 . . _:b482083885 . _:b482083210 . _:b482083221 . _:b482083220 . _:b482083223 . . . _:b482083222 . _:b482085977 . _:b482084893 . _:b482083217 . _:b482084218 . _:b482085895 . _:b482083216 . _:b482083219 . _:b482084800 . _:b482083218 . _:b482084175 . . _:b482083229 . _:b482085166 . _:b482084407 . _:b482083228 . _:b482083833 . . _:b482084309 . _:b482083231 . . _:b482084140 . _:b482083230 . . _:b482086487 . _:b482083225 . . . _:b482083224 . _:b482083227 . . _:b482083226 . _:b482085113 . _:b482083237 . . _:b482084040 . _:b482083236 . . _:b482083239 . _:b482083238 . _:b482084747 . _:b482083233 . . _:b482085251 . . . _:b482084722 . _:b482083232 . _:b482083235 . _:b482083234 . _:b482083229 . _:b482085838 . . _:b482083245 . _:b482083244 . _:b482083247 . _:b482083522 . _:b482083246 . . _:b482083241 . . _:b482083907 . _:b482083240 . _:b482083243 . . _:b482083242 . _:b482086516 . . . _:b482085898 . _:b482083253 . _:b482085201 . . _:b482083252 . _:b482084375 . . _:b482083255 . . _:b482084656 . _:b482083254 . _:b482084467 . _:b482083249 . . _:b482083248 . . _:b482085637 . _:b482084846 . . _:b482083251 . . _:b482086233 . . _:b482083335 . . _:b482083250 . _:b482084981 . _:b482083261 . _:b482083260 . _:b482085365 . . _:b482083263 . . _:b482083262 . _:b482085258 . _:b482085702 . _:b14077292 "In addition to mutations in known AML genes such as DNMT3A8, FLT39, NPM>>110<<, IDH17, IDH211, WT112, RUNX113,14, PTPRT3, PHF615, and ETV616 in these 8 patients, we also discovered novel, recurring mutations in WAC, SMC3, DIS3, DDX41, and DAXX using 200 AML cases whose exomes were sequenced as part of the The Cancer" . _:b482083257 . . _:b482086091 . _:b482086308 . . _:b482083256 . . _:b482083299 . _:b482084725 . _:b482083259 . . _:b482083258 . _:b482085407 . _:b482083269 . . _:b482083268 . _:b482083271 . . _:b482083270 . . _:b482083265 . _:b482083264 . _:b482084694 . _:b482085987 . _:b482083267 . _:b482083266 . _:b482084366 . . _:b482083277 . _:b482083276 . _:b482083312 . _:b482083279 . . _:b482083278 . _:b482084594 . _:b482084327 . _:b482084939 . _:b482083273 . . _:b482083272 . _:b482083275 . . _:b482083274 . . _:b482084437 . . . _:b482083285 . _:b482083284 . _:b482085446 . _:b482085409 . . _:b482083287 . . _:b482083286 . _:b482083281 . . _:b482084182 . . _:b482083280 . _:b482084675 . _:b482083283 . _:b482084064 . . _:b482083231 . _:b482083282 . _:b482083293 . _:b482083582 . _:b482084593 . _:b482083292 . _:b482084192 . _:b482084786 . . _:b482083295 . . . _:b482083294 . _:b482083289 . _:b482083931 . _:b482084216 . _:b482083288 . _:b482083322 . _:b482083291 . . _:b482083290 . _:b482085377 . . _:b482083301 . _:b482083300 . _:b482084929 . . _:b482086353 . _:b482084933 . . _:b482083303 . . _:b482083302 . . _:b482083297 . _:b482084888 . _:b482084058 . _:b482083296 . _:b482083299 . . _:b482084744 . . . . _:b482083298 . _:b482084701 . _:b482083309 . _:b482086382 . _:b482083308 . _:b482084069 . _:b482083311 . _:b482083310 . _:b482083305 . _:b482083304 . _:b482085796 . . _:b482083307 . . _:b482083306 . . _:b482084220 . . _:b482083317 . . _:b482084842 . _:b482083316 . _:b482083319 . _:b482085027 . . _:b482083318 . . . _:b482083313 . _:b482084293 . . _:b482083312 . _:b482085248 . _:b482083315 . _:b482085065 . _:b482083314 . _:b482085337 . _:b482083325 . . _:b482083262 . . _:b482086343 . _:b482083324 . _:b482085852 . . . _:b482083327 . _:b482083326 . . . _:b482083321 . . _:b482083320 . . _:b482083323 . _:b482085674 . _:b482083322 . _:b482083794 . _:b482083961 . . _:b482084791 . _:b482085599 . _:b482086426 . . . . . . _:b482084233 . _:b482085877 . _:b482085886 . . . _:b482085831 . . . . _:b482084255 . . . . _:b482083287 . _:b482084476 . _:b482084909 . . . . . _:b482086020 . . _:b482086119 . . _:b482086256 . _:b482086316 . . . _:b482083563 . . _:b482083296 . . . . . _:b482085233 . _:b482084843 . . . _:b482085119 . _:b482083206 . _:b482084072 . _:b482083320 . . _:b482086231 . . . _:b482085539 . _:b482086204 . _:b482085777 . . _:b482086484 . . . _:b14077311 . . _:b14077303 . . . . _:b482084695 . _:b482084099 . . . _:b14077284 . . . . . . . _:b482085490 . _:b482083641 . _:b482084559 . _:b482085642 . . _:b482086334 . . . _:b482084404 . . . . _:b482083756 . _:b482084625 . . . . . . _:b482084478 . _:b482084620 . _:b482084059 . . _:b482084153 . . _:b482084371 . _:b482086518 . . _:b482084250 . . . _:b482085517 . _:b482086299 . _:b482084821 . _:b482083571 . . . _:b482085235 . _:b482083912 . . . _:b482083860 . . . _:b482084833 . _:b482084657 . _:b482084159 . . . . . . . _:b482083678 . . _:b482086079 . . . . _:b482086315 . _:b482085225 . _:b482084525 . _:b482086174 . . _:b482083503 . . _:b482083356 . . . . . _:b482083754 . _:b482086199 . . _:b482084425 . _:b482083271 . _:b482084947 . . _:b482084379 . _:b482084340 . . . . _:b482086520 . _:b482083218 . _:b482083622 . _:b482086417 . _:b482083431 . . _:b482084400 . . . _:b482083564 . _:b482084836 . . _:b482084324 . . . . _:b482083548 . . _:b482085427 . . _:b482085927 . _:b482086013 . . . . _:b482083784 . . _:b482086282 . . _:b482083649 . _:b482084199 . . . . . . . _:b482085826 . . . . . _:b482085676 . . . . . . . _:b482085081 . _:b482085035 . . _:b482086555 . _:b482085634 . _:b482083734 . . _:b482086064 . _:b482084482 . _:b482084874 . . _:b482086424 . . _:b482085655 . . . _:b482084454 . . . _:b482086323 . . _:b482085861 . . . . _:b482085991 . _:b482085799 . _:b482086300 . _:b482083782 . . . _:b482084432 . _:b482085750 . . . _:b482084213 . . . _:b482085270 . . . _:b482085627 . . _:b482083519 . . _:b482083595 . _:b482083338 . . . _:b482085137 . . . . . _:b482085209 . . . . _:b482084590 . _:b482085114 . . . _:b482084453 . _:b482084102 . . _:b482084760 . _:b482083965 . . . . . _:b482085946 . . . . . . _:b482085993 . _:b482086436 . . . . . . . . . _:b482086370 . _:b482086006 . _:b482083264 . _:b482085717 . . _:b482084924 . _:b482083827 . . _:b482086464 . . _:b482085071 . _:b482083706 . _:b482083830 . . _:b482086271 . . _:b482084000 . _:b482083801 . _:b482085364 . . _:b482085086 . . . . _:b482085449 . _:b482085954 . _:b482084838 . _:b482085349 . _:b482083685 . . . . . . . . _:b14077294 "In addition to mutations in known AML genes such as DNMT3A8, FLT39, NPM110, IDH17, IDH>>211<<, WT112, RUNX113,14, PTPRT3, PHF615, and ETV616 in these 8 patients, we also discovered novel, recurring mutations in WAC, SMC3, DIS3, DDX41, and DAXX using 200 AML cases whose exomes were sequenced as part of the The Cancer Genome Atlas" . . _:b482086041 . _:b482083988 . . _:b482085197 . . . . . . . . . . _:b482086548 . _:b482084830 . . . . _:b482083527 . _:b482084967 . . . _:b482084395 . _:b482085064 . _:b482086387 . _:b482084763 . _:b482085909 . . _:b482085150 . . . . . _:b482083199 . _:b482086407 . . . _:b482084292 . _:b482086535 . . _:b482084314 . _:b482085833 . _:b482083944 . . . _:b482084864 . _:b482084191 . . . . _:b482083583 . . . _:b482084203 . _:b482084343 . _:b482083904 . _:b482085982 . . _:b482086131 . . _:b482085643 . _:b482085157 . _:b482084412 . . _:b482085331 . . _:b482083581 . _:b482083861 . _:b482083326 . . . _:b482084311 . _:b482084555 . . _:b482086349 . _:b482084511 . . . _:b482085442 . _:b482085133 . . . . _:b482084193 . . . . . . . . _:b482083497 . . _:b482084456 . . _:b482084105 . _:b482085023 . . _:b482084470 . . _:b482085319 . . . _:b482083452 . _:b482084940 . _:b482086206 . _:b482083831 . _:b482085902 . . _:b482084803 . _:b482084713 . . _:b482084230 . _:b482083956 . _:b482083658 . _:b482084923 . _:b482084850 . . _:b14077302 "C:G->A:T transversions are the most common mutation in lung cancer patients who were exposed to tobacco-borne carcinogens>>18<< (Fig. 3b and Supplementary Table 11). We examined the 456 relapse-specific mutations and 3590 primary tumor point mutations from all 8 cases as a group, and found that the transversion frequency is significantly higher for" . _:b482085648 . . . _:b482084172 . _:b482084282 . _:b482084539 . _:b482083205 . . . . _:b482085969 . . _:b482084051 . . _:b482083669 . . _:b482085724 . _:b482085361 . _:b482084897 . _:b482084484 . _:b482086525 . _:b482083834 . _:b482083401 . . _:b482084052 . . . . . . . _:b482085297 . _:b482085957 . . . _:b482086447 . . _:b482085913 . . _:b482084809 . . _:b482085481 . _:b482085141 . _:b14077284 . _:b482085772 . _:b14077285 . _:b482085932 . _:b14077286 . _:b14077287 . _:b482086508 . . . . _:b482084129 . . . . . _:b14077292 . . _:b14077293 . _:b482084005 . _:b482086205 . _:b14077294 . . . _:b14077295 . . _:b14077288 . . _:b14077289 . _:b14077290 . _:b482084882 . _:b482085057 . _:b482086341 . _:b14077291 . . _:b14077300 . _:b482086289 . . _:b14077301 . _:b482085530 . . _:b14077302 . . _:b14077303 . . _:b482083343 . . _:b14077296 . . _:b482084424 . _:b482083200 . _:b14077297 . _:b14077298 . _:b14077299 . _:b482084473 . _:b14077308 . _:b14077309 . _:b482084761 . . _:b14077310 . . _:b14077311 . _:b14077304 . _:b482083340 . _:b482083341 . _:b482083342 . _:b14077305 . _:b482083343 . _:b482083336 . _:b482086393 . _:b482083337 . _:b482083338 . _:b14077306 . _:b482083339 . _:b482083332 . _:b482083333 . _:b482085221 . _:b482083334 . _:b14077307 . _:b482083335 . . _:b482083328 . _:b482085789 . _:b482083329 . _:b482084393 . _:b482083330 . _:b482083331 . _:b482083356 . _:b482083357 . _:b482083358 . _:b482083359 . _:b482085708 . _:b482083352 . _:b482083353 . _:b482083354 . _:b482083895 . _:b482083355 . _:b482083348 . _:b482083349 . _:b482083350 . _:b482083416 . _:b482083351 . _:b482085553 . _:b482083344 . _:b482083345 . . _:b14077312 . _:b482083346 . _:b482083347 . _:b482084930 . . _:b482083372 . _:b482083373 . . _:b482083374 . _:b482083375 . _:b482083368 . . _:b482083369 . _:b482083370 . . _:b482083371 . _:b482083364 . _:b482083365 . _:b482083366 . _:b482083367 . _:b482083360 . _:b482084214 . _:b482083361 . _:b482083362 . _:b482083363 . _:b482083388 . . _:b482083389 . . _:b482083390 . _:b482083391 . _:b482083384 . _:b482083385 . . _:b482083386 . _:b482083387 . _:b482083750 . _:b482083380 . _:b482083381 . _:b482083382 . _:b482083383 . . _:b482083376 . _:b482083377 . _:b482083378 . _:b482083379 . _:b482083404 . _:b482083405 . _:b482083406 . _:b482083407 . _:b482083400 . _:b482083401 . _:b482083402 . _:b482083403 . _:b482083396 . _:b482083397 . _:b482083398 . _:b482083399 . _:b482083392 . _:b482084858 . _:b482083393 . _:b482083394 . _:b482083395 . _:b482083420 . _:b482083421 . _:b482083422 . _:b482083423 . . _:b482083416 . _:b482084489 . _:b482083417 . _:b482083418 . . _:b482083419 . _:b482083412 . _:b482083413 . . _:b482083414 . _:b482083415 . _:b482085851 . _:b482084044 . _:b482083408 . _:b482083409 . _:b482083410 . _:b482083411 . _:b482083436 . _:b482085968 . _:b482083437 . _:b482083438 . _:b482083439 . _:b482083432 . _:b482083433 . _:b482083434 . _:b482083435 . _:b482083428 . . _:b482083429 . _:b482083430 . _:b482083431 . _:b482083424 . _:b482083425 . _:b482083426 . _:b482083427 . _:b482083452 . _:b482083453 . _:b482083354 . _:b482083269 . _:b482083454 . _:b482083654 . _:b482086152 . _:b482083455 . . _:b482083448 . _:b482083449 . _:b482083450 . _:b482083451 . _:b482083444 . _:b482083445 . _:b482083446 . _:b482083447 . _:b482083440 . . _:b482086158 . _:b482083441 . _:b482083442 . _:b482086141 . _:b482083443 . _:b482083468 . _:b482083469 . _:b482083470 . . _:b482083471 . _:b482083464 . . _:b482083465 . _:b482083466 . _:b482083467 . _:b482083460 . _:b482083461 . _:b482083539 . _:b482083462 . _:b482083463 . _:b482083456 . _:b482083457 . _:b482083458 . _:b482083459 . _:b482083484 . _:b482083485 . _:b482083486 . _:b482083487 . _:b482083480 . . _:b482085014 . _:b482083481 . _:b482083482 . _:b482083483 . _:b482083476 . _:b482086481 . _:b482083477 . _:b482083478 . _:b482083479 . _:b482083472 . _:b482083473 . _:b482083474 . _:b482083475 . _:b482083500 . . _:b482083501 . . _:b482083502 . . . _:b482083503 . _:b482083496 . _:b482083497 . _:b482086422 . _:b482085170 . _:b482083498 . _:b482083499 . _:b482083492 . _:b482083493 . _:b482083494 . . _:b482083495 . . _:b482083488 . _:b482083489 . _:b482083490 . _:b482083491 . _:b482083516 . _:b482084451 . _:b482084086 . _:b482083517 . . _:b482083518 . _:b482083519 . . _:b482083512 . _:b482083513 . _:b482083514 . _:b482083515 . _:b482083508 . _:b482083509 . _:b482083510 . _:b482083511 . . _:b482083504 . _:b482083505 . _:b482083735 . . . _:b482083506 . _:b482083507 . _:b482083532 . _:b482083533 . _:b482083534 . _:b482083535 . _:b482083528 . _:b482083529 . _:b482083530 . _:b482083531 . _:b482083524 . _:b482083525 . _:b482083526 . _:b482084177 . _:b482083527 . _:b482083520 . _:b482083521 . _:b482083522 . _:b482083523 . _:b482083548 . _:b482083549 . _:b482083550 . . _:b482083551 . . _:b482083544 . _:b482083545 . _:b14077288 . . _:b482083546 . _:b482083547 . _:b482083540 . _:b482083541 . _:b482083542 . _:b482083543 . _:b482083536 . . _:b482083537 . _:b482083538 . _:b482083539 . _:b482083564 . _:b482083565 . _:b482083566 . _:b482083567 . _:b482083560 . . _:b482085581 . . _:b482083561 . . _:b482083562 . _:b482083563 . _:b482083556 . _:b482083557 . _:b482083558 . _:b482083559 . _:b482083552 . _:b482083553 . _:b482083383 . _:b482083554 . _:b482083555 . _:b482083580 . . _:b482083581 . _:b482083582 . _:b482083583 . . _:b482083576 . _:b482083577 . _:b482083578 . _:b482083579 . . _:b482083572 . _:b482083573 . _:b482083574 . _:b482083575 . _:b482083568 . _:b482083569 . _:b482083570 . _:b482083571 . _:b482083596 . _:b482083597 . _:b14077285 . _:b482083598 . _:b482083599 . _:b482083592 . _:b482083593 . _:b482083594 . _:b482083595 . _:b482083588 . _:b482083589 . _:b482085780 . _:b482083590 . _:b482083591 . _:b482083584 . _:b482083585 . _:b482083586 . _:b482083587 . _:b482083612 . _:b482083613 . . _:b482083614 . _:b482083615 . _:b482083608 . _:b482083609 . _:b14077304 . _:b482083610 . _:b482083611 . _:b482083604 . _:b482083605 . . _:b482083606 . _:b482083607 . _:b482083600 . _:b482086405 . _:b482083601 . _:b482083602 . _:b482083603 . _:b482083628 . _:b482086404 . _:b482083629 . _:b482083630 . . _:b482083631 . . _:b482083624 . _:b482086407 . . _:b482083625 . _:b482083626 . _:b482083627 . _:b482083620 . _:b482086406 . _:b482083621 . _:b482084490 . _:b482083622 . _:b482083623 . _:b482083616 . _:b482086401 . _:b482083617 . . _:b482083618 . _:b482083619 . . . _:b482086400 . _:b482083644 . _:b482083645 . _:b482084554 . _:b482083646 . _:b482083647 . _:b482085279 . _:b482083640 . _:b482086403 . _:b482083641 . _:b482083642 . _:b482083643 . _:b482085512 . _:b482083636 . _:b482086402 . _:b482083637 . _:b482083638 . _:b482083639 . _:b482083632 . _:b482086413 . _:b482083633 . _:b14077298 . _:b482083634 . _:b482083635 . . _:b482086412 . _:b482083660 . _:b482083661 . 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_:b482083683 . _:b482086125 . . _:b482086416 . _:b482083708 . _:b482083709 . _:b482083710 . _:b482083711 . _:b482083704 . _:b482086419 . _:b482083705 . _:b482083706 . _:b482083707 . _:b482083700 . _:b482086418 . _:b482083701 . _:b482084709 . _:b482084861 . _:b482083702 . _:b482083703 . _:b482083696 . _:b482086429 . _:b482083697 . _:b482083698 . _:b482083699 . _:b482083724 . _:b482086428 . _:b482083725 . _:b482083726 . _:b482084206 . _:b482083727 . _:b482083720 . _:b482086431 . _:b482083721 . _:b482083722 . _:b482083723 . . _:b482086430 . _:b482083716 . _:b482083717 . _:b482084824 . _:b482083718 . _:b482083719 . _:b482083712 . _:b482086425 . _:b482083713 . _:b482083714 . _:b482083715 . _:b482083740 . _:b482086424 . _:b482083741 . _:b482083742 . _:b482083743 . _:b482085411 . _:b482083736 . _:b482086427 . _:b482083737 . . _:b482083738 . _:b482083739 . _:b482083732 . _:b482086426 . _:b482083733 . _:b482083734 . _:b482083735 . _:b482083728 . _:b482086437 . _:b482083729 . _:b482083730 . _:b482083731 . _:b482083756 . _:b482086436 . . _:b482083757 . _:b482085218 . . _:b482085925 . _:b482083758 . _:b482084103 . _:b482083759 . . _:b482086439 . _:b482083752 . _:b482083753 . _:b482083754 . . _:b482084629 . _:b482083755 . _:b482083748 . _:b482086438 . _:b482085000 . _:b482083749 . _:b482083750 . _:b482083751 . _:b482083744 . _:b482086433 . . _:b482083745 . . _:b482083746 . _:b482085779 . _:b482083747 . _:b482083772 . _:b482086432 . . _:b482083773 . _:b482083662 . _:b482083774 . _:b482084376 . _:b482083775 . _:b482083768 . _:b482086435 . _:b482083886 . _:b482083769 . _:b482083770 . _:b482083771 . _:b482083764 . _:b482086434 . _:b482083765 . _:b482083766 . _:b482083767 . _:b482083760 . _:b482086445 . _:b482086202 . _:b482083761 . _:b482086416 . _:b482083762 . _:b482083763 . _:b482084928 . _:b482084246 . _:b482086444 . _:b482083788 . _:b482083789 . _:b482083790 . _:b482083791 . _:b482083784 . _:b482086447 . _:b482083785 . _:b482083786 . _:b482083787 . _:b482083780 . _:b482086446 . _:b482083781 . _:b482083782 . _:b482083783 . _:b482083776 . _:b482086441 . _:b482083777 . _:b482083778 . . _:b482083779 . _:b482083804 . _:b482086440 . _:b482083805 . _:b482083806 . _:b482083807 . _:b482083800 . _:b482086443 . . _:b482083801 . _:b482083802 . _:b482083803 . _:b482083796 . _:b482086442 . _:b482083797 . _:b482084428 . _:b482083798 . . _:b482083799 . _:b482083203 . _:b482086453 . _:b482083792 . _:b482083793 . _:b482083794 . _:b482083201 . _:b482083795 . _:b482083715 . _:b482086452 . _:b482083820 . _:b482083821 . _:b482083822 . _:b482083823 . . _:b482083816 . _:b482086455 . _:b482083817 . _:b482083985 . _:b482083818 . _:b482083819 . . _:b482086454 . _:b482083812 . _:b482083813 . . _:b482083814 . _:b482083815 . _:b482083808 . _:b482086449 . _:b482083809 . _:b482083810 . _:b482083811 . . _:b482086448 . _:b482083836 . _:b482083837 . _:b482083838 . _:b482083839 . _:b482083832 . _:b482086451 . _:b482083833 . . _:b482086025 . _:b482083834 . _:b482083835 . _:b482083828 . _:b482086450 . _:b482083829 . _:b482083830 . _:b482083831 . _:b482083824 . _:b482086461 . _:b482083825 . _:b482083826 . _:b482083827 . _:b482086460 . . _:b482086463 . _:b482086462 . _:b482083810 . _:b482086457 . _:b482085846 . _:b482086456 . _:b482086459 . . _:b482086458 . _:b482086469 . _:b482086468 . . _:b482086471 . _:b482086470 . . _:b482086465 . _:b482086464 . _:b482086467 . . _:b482085938 . _:b482085588 . _:b482086466 . . _:b482086477 . _:b482084745 . . _:b482086476 . _:b482083236 . _:b482084963 . _:b482086479 . . . _:b482086478 . _:b482086473 . _:b482084440 . _:b482085956 . . _:b482086472 . . _:b482086475 . _:b482084475 . _:b482086474 . . _:b482085158 . . _:b482084357 "3"^^ . _:b482086485 . . _:b482084356 "3"^^ . . _:b482085540 . _:b482086484 . _:b482084359 "3"^^ . _:b482086085 . _:b482086487 . _:b482084358 "3"^^ . _:b482085569 . _:b482085986 . _:b482086486 . _:b482084409 . _:b482084353 "3"^^ . _:b482083858 . _:b482085396 . _:b482086481 . _:b482084352 "3"^^ . _:b482085791 . _:b482086480 . _:b482085945 . _:b482084355 "3"^^ . _:b482084537 . _:b482086483 . _:b482084354 "3"^^ . _:b482086482 . _:b482084365 "3"^^ . _:b482086493 . _:b482084410 . _:b482084364 "3"^^ . _:b482085863 . _:b482085253 . _:b482086492 . _:b482084367 "3"^^ . _:b482086495 . _:b482084366 "3"^^ . _:b482085783 . . _:b482086494 . _:b482084361 "3"^^ . _:b482084793 . _:b482086489 . _:b482084360 "3"^^ . _:b482086488 . _:b482084363 "3"^^ . . _:b482086491 . _:b482084362 "3"^^ . . _:b482086490 . _:b482084373 "3"^^ . _:b482086501 . . . _:b482084372 "3"^^ . . _:b482086500 . . _:b482084375 "3"^^ . . _:b482086503 . _:b482083644 . _:b482084374 "3"^^ . _:b482086502 . _:b482084369 "3"^^ . . _:b482086497 . _:b482084368 "3"^^ . _:b482084503 . _:b482086016 . _:b482086496 . _:b482084371 "3"^^ . . . _:b482086499 . _:b482084370 "3"^^ . _:b482086498 . _:b482084381 "3"^^ . _:b482086509 . _:b482084380 "3"^^ . . _:b482086508 . _:b482084383 "3"^^ . . _:b482086511 . _:b482084382 "3"^^ . . _:b482086510 . _:b482085672 . _:b482083620 . _:b482084377 "3"^^ . _:b482086505 . _:b482084376 "3"^^ . _:b482086504 . _:b482084379 "3"^^ . _:b482086374 . _:b482086507 . . _:b482084378 "3"^^ . _:b482086506 . _:b482083807 . _:b482084389 "3"^^ . _:b482084700 . _:b482084632 . _:b482083612 . _:b482086517 . _:b482084388 "3"^^ . . _:b482086516 . _:b482086262 . _:b482084391 "3"^^ . _:b482086519 . _:b482084577 . _:b482084438 . _:b482084390 "3"^^ . _:b482086518 . . _:b482084385 "3"^^ . _:b482083440 . _:b482085243 . _:b482086513 . _:b482084384 "3"^^ . _:b482084579 . _:b482086512 . _:b482084387 "3"^^ . _:b482084644 . _:b482086515 . _:b482084386 "3"^^ . _:b482086514 . _:b482084397 "3"^^ . _:b482086525 . _:b482084396 "3"^^ . _:b482086524 . . _:b482084399 "3"^^ . _:b482084886 . _:b482086527 . _:b482084398 "3"^^ . . _:b482086526 . _:b482084393 "3"^^ . _:b482086521 . _:b482085098 . _:b482084392 "3"^^ . _:b482086520 . . _:b482084395 "3"^^ . _:b482086523 . _:b482084394 "3"^^ . . . _:b482086522 . _:b482083816 . _:b482083687 . _:b482084405 "3"^^ . _:b482086533 . _:b482085574 . _:b482084404 "3"^^ . . _:b482086532 . _:b482084407 "3"^^ . _:b482086535 . _:b482084406 "3"^^ . . . _:b482086534 . _:b482084401 "3"^^ . _:b482086529 . _:b482084400 "3"^^ . _:b482084362 . . _:b482086528 . . _:b482084403 "3"^^ . _:b482086531 . _:b482084402 "3"^^ . _:b482085931 . . _:b482086530 . _:b482084413 "3"^^ . . . _:b482086541 . _:b482084412 "3"^^ . _:b482086540 . _:b482083892 . _:b482084415 "3"^^ . _:b482083436 . _:b482086543 . _:b482084414 "3"^^ . _:b482083911 . _:b482086542 . _:b482084409 "3"^^ . _:b482085342 . _:b482086537 . _:b482085757 . _:b482084408 "3"^^ . _:b482086536 . _:b482084411 "3"^^ . _:b482086539 . . _:b482084410 "3"^^ . _:b482086538 . _:b482084421 "3"^^ . _:b482085063 . _:b482085958 . . _:b482086549 . _:b482084762 . _:b482084420 "3"^^ . _:b482085232 . _:b482083373 . _:b482083180 . _:b482086548 . _:b482083181 . _:b482085621 . . _:b482083182 . _:b482084423 "3"^^ . _:b482083183 . _:b482086551 . _:b482084422 "3"^^ . _:b482083179 . . _:b482086550 . _:b482084417 "3"^^ . _:b482084349 . _:b482083514 . _:b482086545 . _:b482085148 . . _:b482084416 "3"^^ . . _:b482086544 . _:b482083196 . _:b482083197 . _:b482084419 "3"^^ . _:b482083198 . _:b482083199 . _:b482083192 . _:b482086547 . _:b482083193 . _:b482084418 "3"^^ . _:b482083194 . _:b482083195 . _:b482083188 . _:b482086546 . _:b482083189 . _:b482084429 "3"^^ . _:b482083190 . . _:b482083191 . _:b482083184 . _:b482086557 . _:b482083185 . . _:b482084428 "3"^^ . _:b482083186 . _:b482083187 . _:b482083212 . _:b482086556 . _:b482083213 . _:b482084431 "3"^^ . _:b482083214 . _:b482083215 . _:b482083208 . _:b482086559 . _:b482083209 . _:b482084430 "3"^^ . _:b482083210 . _:b482083211 . _:b482083204 . _:b482086558 . _:b482083205 . _:b482084425 "3"^^ . _:b482083206 . . _:b482083207 . _:b482084010 . _:b482086553 . _:b482083200 . _:b482083201 . _:b482084424 "3"^^ . _:b482083202 . . _:b482083203 . _:b482083228 . _:b482086552 . _:b482083229 . _:b482084427 "3"^^ . _:b482083230 . _:b482083231 . _:b482083224 . _:b482086555 . _:b482086494 . . _:b482083225 . _:b482084426 "3"^^ . _:b482083226 . _:b482083227 . _:b482083220 . _:b482086554 . _:b482083221 . . _:b482083222 . _:b482084437 "3"^^ . _:b482083223 . _:b482083216 . _:b482083217 . _:b482084436 "3"^^ . _:b482083218 . _:b482083995 . _:b482083219 . . _:b482083244 . _:b482084287 . _:b482083245 . _:b482084439 "3"^^ . _:b482083246 . . _:b482083247 . _:b482083240 . _:b482083241 . _:b482084438 "3"^^ . _:b482083242 . _:b482083243 . . _:b482083236 . . _:b482083237 . _:b482084433 "3"^^ . _:b482083238 . . _:b482083239 . _:b482085897 . _:b482083232 . _:b482086561 . _:b482083233 . _:b482083957 . _:b482084432 "3"^^ . _:b482083234 . _:b482083235 . _:b482085743 . _:b482083260 . _:b482086560 . _:b482083261 . _:b482086411 . _:b482084435 "3"^^ . _:b482083262 . _:b482083263 . _:b482083256 . _:b482083257 . . _:b482084434 "3"^^ . _:b482083258 . _:b482083259 . _:b482083252 . _:b482083253 . _:b482086097 . _:b482084445 "3"^^ . _:b482083254 . . _:b482083255 . _:b482083248 . _:b482083249 . _:b482084444 "3"^^ . _:b482083250 . _:b482084517 . _:b482083251 . _:b482083276 . _:b482085892 . _:b482083277 . _:b482084447 "3"^^ . _:b482083278 . _:b482083279 . _:b482083272 . _:b482083273 . _:b482084446 "3"^^ . _:b482083274 . _:b482083275 . _:b482083268 . _:b482083269 . _:b482084441 "3"^^ . _:b482083270 . _:b482083271 . . _:b482083264 . _:b482083265 . _:b482086350 . _:b482084440 "3"^^ . _:b482083266 . _:b482083267 . _:b482083292 . _:b482083293 . _:b482084443 "3"^^ . _:b482083294 . _:b482083295 . _:b482083288 . _:b482083656 . _:b482083289 . . _:b482084442 "3"^^ . _:b482083290 . _:b482083366 . _:b482083291 . _:b482083835 . _:b482083284 . _:b482083285 . _:b482086014 . _:b482084453 "3"^^ . _:b482083286 . _:b482083287 . _:b482085168 . _:b482083280 . _:b482083625 . _:b482083281 . _:b482084452 "3"^^ . _:b482083282 . _:b482083283 . _:b482083308 . _:b482083309 . _:b482084455 "3"^^ . _:b482085401 . _:b482083310 . _:b482083311 . _:b482083304 . . _:b482083305 . _:b482084454 "3"^^ . _:b482083306 . _:b482083307 . . _:b482083300 . _:b482083301 . _:b482084449 "3"^^ . _:b482083302 . _:b482083303 . _:b482083296 . _:b482083297 . _:b482084448 "3"^^ . _:b482085659 . _:b482083298 . . _:b482083299 . _:b482083324 . _:b482083394 . . _:b482083325 . _:b482084451 "3"^^ . _:b482083326 . _:b482083412 . _:b14077307 "19, Anderson et al.20, and Notta et al.>>21<<, who recently described patterns of clonal evolution in ALL patients using FISH and/or copy number alterations detected by SNP arrays, and it enhances the understanding of genetic changes acquired during disease progression, as previously" . _:b482083327 . _:b482083320 . . _:b482083321 . . _:b482084450 "3"^^ . _:b482083322 . _:b482083323 . _:b482083316 . _:b482083317 . . _:b482084461 "3"^^ . _:b482083318 . . _:b482083319 . _:b482083312 . _:b482083313 . _:b482084884 . _:b482083314 . _:b482084460 "3"^^ . _:b482083315 . _:b482084364 . _:b482085720 . _:b482084365 . _:b482084463 "3"^^ . _:b482084366 . _:b482084367 . _:b482084360 . _:b482083983 . _:b482084361 . _:b482084462 "3"^^ . _:b482084362 . _:b482084363 . _:b482084356 . _:b482085997 . _:b482084357 . _:b482084457 "3"^^ . _:b482084358 . _:b482084359 . _:b482084352 . _:b482084353 . _:b482085691 . _:b482084456 "3"^^ . _:b482084945 . _:b482084354 . _:b482084355 . _:b482084380 . _:b482084381 . _:b482084459 "3"^^ . _:b482084382 . _:b482084383 . _:b482084376 . _:b482084377 . _:b482084458 "3"^^ . _:b482084378 . _:b482084583 . _:b482084379 . _:b482084372 . _:b482084373 . _:b482084469 "3"^^ . _:b482084374 . _:b482084375 . _:b482084368 . _:b482084369 . . _:b482084370 . _:b482084468 "3"^^ . . _:b482084371 . _:b482084396 . _:b482086339 . _:b482084397 . _:b482084471 "3"^^ . _:b482084398 . _:b482084399 . _:b482084392 . . _:b482084393 . _:b482084470 "3"^^ . _:b482084394 . _:b482084395 . _:b482084388 . _:b482084389 . _:b482084465 "3"^^ . _:b482084390 . _:b482084391 . _:b482084384 . _:b482084385 . _:b482084464 "3"^^ . . _:b482084386 . _:b482084251 . _:b482084387 . _:b482084412 . _:b482084413 . . _:b482084414 . . _:b482084467 "3"^^ . _:b482084415 . _:b482084408 . _:b482084409 . _:b482084466 "3"^^ . _:b482084410 . _:b482084411 . _:b482084404 . _:b482084405 . _:b482084477 "3"^^ . _:b482084406 . _:b482084407 . _:b482084400 . _:b482084401 . _:b482084476 "3"^^ . _:b482084271 . _:b482084402 . _:b482084403 . . _:b482084428 . _:b482084429 . . _:b482084430 . _:b482084479 "3"^^ . . _:b482084431 . _:b482084424 . _:b482084425 . _:b482085260 . . _:b482084426 . . _:b482084478 "3"^^ . _:b482084427 . _:b482084420 . . _:b482084421 . _:b482084473 "3"^^ . _:b482084422 . _:b482084423 . _:b482084416 . _:b482086036 . _:b482084417 . _:b482084472 "3"^^ . _:b482084418 . . _:b482084419 . . _:b482084444 . _:b482084445 . _:b482084475 "3"^^ . . _:b482084446 . _:b482084447 . _:b482084440 . _:b482084441 . _:b482084474 "3"^^ . _:b482084442 . _:b482084443 . _:b482084436 . _:b482084437 . _:b482084485 "3"^^ . _:b482084438 . _:b482084728 . _:b482085579 . _:b482084439 . _:b482084432 . _:b482084433 . . _:b482084434 . . _:b482084484 "3"^^ . . _:b482084435 . _:b482084460 . _:b482084461 . _:b482084487 "3"^^ . _:b482084462 . _:b482084463 . _:b482084464 . _:b482084456 . _:b482084457 . . _:b14077296 "In addition to mutations in known AML genes such as DNMT3A8, FLT39, NPM110, IDH17, IDH211, WT112, RUNX>>113<<,14, PTPRT3, PHF615, and ETV616 in these 8 patients, we also discovered novel, recurring mutations in WAC, SMC3, DIS3, DDX41, and DAXX using 200 AML cases whose exomes were sequenced as part of the The Cancer Genome Atlas AML project" . _:b482084458 . _:b482084486 "3"^^ . _:b482084459 . _:b482083584 . _:b482084452 . _:b482084453 . _:b482085856 . _:b482084481 "3"^^ . _:b482084454 . _:b482084455 . _:b482084448 . _:b482084449 . _:b482084480 "3"^^ . _:b482084450 . . _:b482084451 . _:b482083566 . _:b482084476 . . . _:b482084477 . _:b482084483 "3"^^ . _:b482084478 . _:b482084479 . _:b482084472 . _:b482084473 . _:b482084944 . _:b482084482 "3"^^ . _:b482086102 . _:b482084474 . _:b482084475 . _:b482084468 . _:b482084469 . . _:b482084470 . _:b482084493 "3"^^ . _:b482084471 . _:b482084464 . . _:b482084465 . _:b482084492 "3"^^ . _:b482084466 . _:b482084467 . _:b482084492 . _:b482084493 . _:b482084495 "3"^^ . _:b482084494 . . _:b482084495 . _:b482084488 . _:b482084489 . _:b482084494 "3"^^ . _:b482084490 . _:b482084491 . _:b482084484 . _:b482084485 . _:b482084489 "3"^^ . _:b482084486 . _:b482084487 . _:b482084480 . _:b482084481 . . . _:b482084482 . _:b482084488 "3"^^ . _:b482084483 . _:b482084508 . _:b482083282 . _:b482085470 . _:b482084509 . . _:b482084491 "3"^^ . _:b482086403 . . _:b482084510 . _:b482084511 . _:b482084504 . _:b482084505 . . _:b482084506 . _:b482084490 "3"^^ . _:b482084458 . _:b482084507 . _:b482084500 . _:b482084501 . _:b482084501 "3"^^ . _:b482084502 . . _:b482084503 . _:b482084496 . _:b482084497 . _:b482084500 "3"^^ . _:b482084498 . _:b482084499 . . _:b482084524 . . _:b482084525 . _:b482084503 "3"^^ . _:b482085095 . _:b482084526 . _:b482084527 . _:b482084520 . _:b482083474 . _:b482084521 . _:b482084502 "3"^^ . _:b482084522 . _:b482084523 . _:b482084496 . _:b482084516 . _:b482084517 . _:b482084497 "3"^^ . _:b482084518 . _:b482084519 . _:b482084512 . _:b482084513 . _:b482084496 "3"^^ . _:b482084514 . _:b482083521 . _:b482085346 . _:b482084515 . _:b482084540 . _:b482084541 . _:b482085537 . _:b482084499 "3"^^ . _:b482084542 . _:b482084013 . _:b482085695 . _:b482084543 . _:b482084536 . _:b482084537 . _:b482084498 "3"^^ . _:b482084538 . _:b482084539 . _:b482084532 . _:b482084533 . _:b482084509 "3"^^ . _:b482084534 . _:b482084535 . . _:b482084528 . . _:b482084529 . . _:b482084530 . _:b482084508 "3"^^ . _:b482084531 . _:b482085889 . _:b482085554 . _:b482084556 . _:b482084007 . _:b482084557 . _:b482084511 "3"^^ . _:b482084558 . _:b482084559 . _:b482084552 . . _:b482084553 . _:b482084510 "3"^^ . _:b482084554 . _:b482084738 . _:b482084555 . _:b482084548 . _:b482084549 . _:b482084505 "3"^^ . _:b482084550 . . _:b482084551 . _:b482084544 . _:b482084545 . _:b482084504 "3"^^ . _:b482084546 . . _:b482084547 . _:b482084572 . _:b482084573 . . _:b482084574 . _:b482084507 "3"^^ . _:b482084575 . _:b482084568 . _:b482084569 . _:b482084506 "3"^^ . _:b482084570 . _:b482084571 . _:b482084564 . _:b482084565 . _:b482084517 "3"^^ . _:b482084566 . _:b482084567 . _:b482084560 . _:b482083213 . _:b482084561 . _:b482084516 "3"^^ . . _:b482084562 . _:b482084563 . _:b482084588 . _:b482084589 . _:b482084519 "3"^^ . _:b482084590 . _:b482084591 . _:b482084584 . _:b482084585 . _:b482084518 "3"^^ . _:b482084586 . _:b482084587 . _:b482084810 . _:b482084580 . _:b482084581 . _:b482084513 "3"^^ . _:b482084582 . _:b482084583 . _:b482085696 . _:b482084576 . _:b482084577 . _:b482084512 "3"^^ . _:b482084578 . _:b482084579 . _:b482084604 . _:b482084605 . _:b482084515 "3"^^ . _:b482086503 . _:b482084606 . . _:b482084607 . _:b482084600 . _:b482084601 . _:b482084514 "3"^^ . _:b482084602 . _:b482084603 . _:b482084596 . _:b482085215 . _:b482084597 . _:b482084525 "3"^^ . _:b482084598 . _:b482084599 . _:b482084592 . . _:b482084593 . _:b482084524 "3"^^ . _:b482084594 . . _:b482084595 . _:b482084620 . _:b482084621 . _:b482084527 "3"^^ . _:b482084622 . _:b482084136 . _:b482084623 . _:b482084616 . . _:b482084617 . _:b482084526 "3"^^ . _:b482084618 . _:b482084619 . _:b482084612 . _:b482084613 . _:b482084521 "3"^^ . _:b482084614 . _:b482084615 . . _:b482084608 . _:b482084609 . _:b482084520 "3"^^ . _:b482084610 . _:b482084611 . _:b482084636 . _:b482084637 . _:b482084523 "3"^^ . _:b482084638 . . _:b482084639 . . _:b482084632 . _:b482084633 . _:b482084522 "3"^^ . _:b482084634 . _:b482084635 . _:b482084628 . _:b482084629 . _:b482085222 . _:b482084533 "3"^^ . _:b482084630 . _:b482084631 . _:b482084624 . _:b482086149 . _:b482084625 . _:b482084532 "3"^^ . _:b482084626 . _:b482084627 . _:b482085272 . _:b482084652 . _:b482086148 . _:b482084653 . 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_:b482086280 . _:b482084188 . _:b482084667 "2"^^ . _:b482084189 . _:b482084190 . _:b482084191 . _:b482084184 . _:b482086283 . _:b482084666 "2"^^ . _:b482084185 . _:b482084671 . _:b482084186 . _:b482084187 . _:b482084180 . _:b482086282 . _:b482084677 "2"^^ . _:b482084181 . _:b482084182 . _:b482084183 . _:b482084176 . _:b482086293 . _:b482084676 "2"^^ . _:b482084177 . _:b482084178 . . . _:b482084179 . _:b482083982 . _:b482084204 . _:b482086292 . _:b482084679 "2"^^ . _:b482084205 . _:b482084206 . _:b482084207 . . _:b482084200 . _:b482086295 . _:b482084678 "2"^^ . _:b482084201 . _:b482084202 . _:b482084203 . _:b482084196 . _:b482086294 . _:b482084673 "2"^^ . _:b482084197 . _:b482084303 . _:b482084198 . _:b482084199 . _:b482084192 . _:b482086289 . _:b482084672 "2"^^ . _:b482084193 . _:b482084194 . . _:b482085639 . _:b482084195 . . . _:b482086288 . _:b482084220 . _:b482084675 "2"^^ . _:b482084221 . _:b482084222 . _:b482084223 . _:b482084216 . _:b482086291 . _:b482084674 "2"^^ . _:b482084217 . _:b482084218 . _:b482084219 . _:b482084212 . _:b482086290 . . . _:b482084213 . _:b482084685 "2"^^ . _:b482084214 . . _:b482084215 . _:b482084208 . _:b482086301 . _:b482084684 "2"^^ . _:b482084209 . . _:b482084210 . _:b482084211 . _:b482084236 . _:b482086300 . _:b482084687 "2"^^ . _:b482084237 . _:b482084238 . _:b482086462 . . _:b482085403 . _:b482084239 . _:b482084232 . _:b482086303 . . _:b482084233 . _:b482084686 "2"^^ . _:b482084234 . _:b482084235 . . _:b482086302 . _:b482084228 . _:b482084681 "2"^^ . _:b482084229 . _:b482084230 . . _:b482084231 . _:b482084224 . _:b482086297 . _:b482085748 . _:b482083238 . _:b482084225 . _:b482084680 "2"^^ . _:b482084226 . _:b482084227 . _:b482084252 . _:b482086296 . _:b482084683 "2"^^ . _:b482084253 . _:b482084254 . _:b482084255 . _:b482084248 . _:b482086299 . _:b482084682 "2"^^ . _:b482084249 . _:b482084775 . _:b482084250 . _:b482084251 . _:b482084674 . _:b482086298 . _:b482084244 . _:b482084693 "2"^^ . _:b482084245 . _:b482084246 . _:b482084247 . _:b482084240 . _:b482086309 . _:b482084692 "2"^^ . _:b482086444 . _:b482084241 . _:b482084242 . _:b482084243 . _:b482084268 . _:b482086308 . _:b482084695 "2"^^ . _:b482084269 . _:b482084270 . _:b482084271 . _:b482084264 . _:b482086311 . _:b482084694 "2"^^ . _:b482085692 . _:b482084265 . _:b482084266 . _:b482084267 . _:b482084260 . _:b482086310 . _:b482084689 "2"^^ . _:b482084261 . _:b482084262 . _:b482084263 . _:b482084256 . _:b482086305 . _:b482084688 "2"^^ . _:b482085967 . _:b482084257 . _:b482084258 . _:b482084259 . _:b482084284 . _:b482086304 . _:b482084691 "2"^^ . _:b482084285 . _:b482083787 . _:b482085051 . _:b482084286 . _:b482084287 . _:b482086258 . _:b482084280 . _:b482086307 . _:b482083513 . _:b482084281 . _:b482084690 "2"^^ . _:b482084282 . _:b482084283 . _:b482084276 . _:b482086306 . _:b482084701 "2"^^ . _:b482084277 . _:b482084278 . _:b482084279 . . _:b482086317 . _:b482084272 . _:b482084700 "2"^^ . _:b482084273 . _:b482084274 . _:b482084275 . _:b482084300 . _:b482086316 . _:b482084703 "2"^^ . _:b482084301 . _:b482084302 . _:b482084303 . _:b482084296 . _:b482086319 . _:b482084702 "2"^^ . _:b482084297 . _:b482084298 . . _:b482084299 . _:b482084292 . _:b482086318 . _:b482084697 "2"^^ . _:b482084293 . . _:b482084294 . . _:b482084716 . _:b482084295 . _:b482084288 . _:b482086313 . _:b482084696 "2"^^ . _:b482084289 . _:b482084290 . _:b482084291 . _:b482084316 . _:b482086312 . _:b482084699 "2"^^ . _:b482085298 . _:b482084317 . _:b482084318 . _:b482084319 . _:b482086105 . _:b482084312 . _:b482086315 . . _:b482084313 . _:b482084698 "2"^^ . . _:b482084314 . _:b482084315 . _:b482084308 . _:b482086314 . _:b482084709 "2"^^ . _:b482084309 . . _:b482084310 . _:b482084311 . . _:b482084304 . _:b482086325 . . _:b482084305 . _:b482084708 "2"^^ . _:b482084306 . . _:b482084307 . _:b482084332 . _:b482086324 . _:b482083586 . _:b482084333 . _:b482084711 "2"^^ . _:b482084334 . . . _:b482084335 . _:b482084328 . _:b482086327 . _:b482084570 . _:b482084329 . _:b482084710 "2"^^ . _:b482084330 . _:b482084009 . _:b482084331 . _:b482084031 . _:b482086326 . _:b482084324 . _:b482084705 "2"^^ . _:b482084325 . _:b482084326 . _:b482084327 . _:b482084320 . _:b482086321 . _:b482084704 "2"^^ . _:b482085586 . _:b482084321 . _:b482084322 . _:b482084323 . _:b482084348 . _:b482086320 . _:b482084707 "2"^^ . _:b482084349 . _:b482084350 . _:b482084351 . . _:b482086323 . _:b482084344 . . _:b482084345 . _:b482084706 "2"^^ . _:b482084346 . _:b482084347 . _:b482084340 . _:b482086322 . _:b482084717 "2"^^ . _:b482084341 . _:b482084342 . _:b482084343 . _:b482083193 . _:b482084336 . _:b482086333 . _:b482084716 "2"^^ . _:b482084337 . _:b482084338 . . _:b482084339 . _:b482085388 . _:b482086332 . . _:b482085389 . _:b482084719 "2"^^ . _:b482085390 . _:b482085391 . _:b482085384 . _:b482086335 . _:b482084718 "2"^^ . _:b482085385 . . _:b482085386 . _:b482085387 . . _:b482086334 . _:b482085380 . . _:b482085381 . _:b482084713 "2"^^ . _:b482085382 . _:b482085383 . . _:b482086329 . _:b482085376 . _:b482084712 "2"^^ . _:b482085377 . _:b482085378 . _:b482085379 . _:b482085404 . _:b482086328 . _:b482084715 "2"^^ . _:b482085405 . _:b482083673 . _:b482085406 . _:b482085407 . _:b14077306 . _:b482085400 . _:b482086331 . _:b482084714 "2"^^ . _:b482085401 . . _:b482085402 . . _:b482085403 . _:b482085396 . _:b482086330 . _:b482084725 "2"^^ . _:b482085397 . _:b482085398 . _:b482085399 . _:b482085392 . _:b482086341 . _:b482084724 "2"^^ . _:b482085393 . . _:b482085394 . _:b482084435 . _:b482085395 . . _:b482085420 . _:b482086340 . _:b482084727 "2"^^ . _:b482085421 . _:b482085422 . _:b482085423 . _:b482085416 . _:b482086343 . _:b482084726 "2"^^ . _:b482085417 . _:b482085418 . _:b482085419 . _:b482085412 . _:b482086342 . _:b482086330 . . _:b482085413 . _:b482084721 "2"^^ . _:b482085414 . _:b482084733 . _:b482085415 . . _:b482086337 . _:b482085479 . _:b482085408 . _:b482084720 "2"^^ . _:b482085409 . . _:b482085683 . _:b482085410 . . _:b482083553 . _:b482085411 . _:b482085436 . _:b482086336 . _:b482084723 "2"^^ . _:b482085437 . _:b482085438 . _:b482085439 . _:b482085432 . _:b482086339 . _:b482084722 "2"^^ . _:b482085433 . _:b482085434 . _:b482086008 . _:b482085435 . _:b482085428 . _:b482086338 . _:b482084733 "2"^^ . _:b482085429 . _:b482085430 . . _:b482085431 . _:b482085424 . _:b482086349 . _:b482084732 "2"^^ . _:b482085425 . _:b482085426 . . _:b482085427 . _:b482085452 . _:b482086348 . . _:b482085453 . _:b482084735 "2"^^ . _:b482085454 . _:b482084236 . _:b482085455 . _:b482085448 . _:b482086499 . _:b482086351 . _:b482084734 "2"^^ . _:b482086069 . _:b482085449 . . _:b482085450 . _:b482085451 . _:b482085444 . _:b482086350 . _:b482084729 "2"^^ . _:b482085445 . _:b482085446 . _:b482085447 . _:b482084276 . _:b482086345 . _:b482085567 . _:b482085440 . . _:b482084728 "2"^^ . _:b482085441 . _:b482085442 . _:b482085443 . _:b482085468 . _:b482086344 . _:b482085126 . _:b482084731 "2"^^ . _:b482085469 . _:b482085470 . _:b14077291 "In addition to mutations in known AML genes such as DNMT3A8, FLT>>39<<, NPM110, IDH17, IDH211, WT112, RUNX113,14, PTPRT3, PHF615, and ETV616 in these 8 patients, we also discovered novel, recurring mutations in WAC, SMC3, DIS3, DDX41, and DAXX using 200 AML cases whose exomes were sequenced as part of the" . _:b482085471 . _:b482085464 . _:b482086347 . _:b482084730 "2"^^ . _:b482085465 . _:b482085466 . _:b482085467 . _:b482085460 . _:b482086346 . . _:b482085461 . _:b482084741 "2"^^ . _:b482085462 . _:b482085463 . _:b482085456 . _:b482086357 . _:b482084740 "2"^^ . _:b482085457 . _:b482085458 . _:b482085459 . _:b482083450 . _:b482086356 . _:b482085484 . _:b482084743 "2"^^ . _:b482085485 . _:b482085486 . _:b482085487 . _:b482085480 . _:b482086359 . _:b482084742 "2"^^ . _:b482085481 . _:b482085482 . . _:b482085483 . _:b482085476 . _:b482086358 . _:b482084737 "2"^^ . _:b482085477 . _:b482085478 . _:b482085479 . . _:b482086353 . _:b482085472 . _:b482084736 "2"^^ . _:b482085473 . _:b482085474 . . _:b482085475 . _:b482085500 . _:b482086352 . _:b482084739 "2"^^ . _:b482085501 . _:b482085502 . _:b482085503 . _:b482085496 . _:b482086355 . _:b482084081 . _:b482085497 . _:b482084738 "2"^^ . _:b482085498 . _:b482085499 . _:b482085492 . _:b482086354 . _:b482084749 "2"^^ . _:b482085493 . . _:b482085829 . _:b482083360 . _:b482085494 . _:b482084684 . _:b482085495 . _:b482085488 . _:b482086365 . _:b482084748 "2"^^ . _:b482085489 . _:b482085490 . . _:b482085491 . _:b482085516 . _:b482086364 . _:b482084751 "2"^^ . _:b482085517 . _:b482085518 . _:b482085519 . _:b482085512 . _:b482086367 . _:b482084750 "2"^^ . _:b482085513 . _:b482085514 . _:b482085515 . _:b482085508 . _:b482086366 . _:b482084745 "2"^^ . _:b482085509 . _:b482085510 . _:b482085511 . _:b482085504 . _:b482086361 . _:b482084744 "2"^^ . _:b482085505 . _:b482085506 . _:b482085507 . _:b482085532 . _:b482086360 . _:b482084747 "2"^^ . _:b482085533 . _:b482085534 . _:b482085535 . _:b482084597 . _:b482086363 . _:b482085528 . _:b482084746 "2"^^ . _:b482085529 . . _:b482085530 . _:b482085531 . _:b482085356 . _:b482084066 . _:b482086362 . _:b482085524 . . _:b482085525 . _:b482084757 "2"^^ . _:b482085526 . _:b482085527 . _:b482086513 . _:b482085520 . _:b482086373 . _:b482084756 "2"^^ . _:b482085521 . _:b482085522 . _:b482085523 . _:b482085548 . _:b482086372 . _:b482084759 "2"^^ . _:b482085549 . _:b482085550 . _:b482085551 . _:b482085544 . _:b482086375 . _:b482084758 "2"^^ . _:b482085545 . _:b482085546 . _:b482085547 . _:b482085540 . _:b482086374 . . _:b482085541 . _:b482084753 "2"^^ . _:b482085542 . _:b482085543 . _:b482085536 . _:b482086369 . _:b482084752 "2"^^ . _:b482085537 . _:b482085538 . _:b482083838 . _:b482085539 . _:b482085564 . _:b482086368 . _:b482084755 "2"^^ . _:b482085565 . _:b482084854 . _:b482085566 . _:b482085567 . _:b482085560 . _:b482086371 . _:b482084754 "2"^^ . _:b482085561 . _:b482085562 . _:b482085563 . . _:b482086370 . _:b482085556 . _:b482084765 "2"^^ . _:b482085557 . _:b482085558 . _:b482085559 . _:b482083375 . _:b482086381 . . _:b482085552 . _:b482084764 "2"^^ . _:b482085553 . _:b482085554 . _:b482085555 . _:b482085580 . _:b482086380 . _:b482085280 . _:b482084767 "2"^^ . _:b482085581 . _:b482083948 . . _:b482085582 . _:b482085583 . . _:b482086383 . _:b482085576 . _:b482084766 "2"^^ . _:b482085577 . _:b482085578 . _:b482085461 . _:b482085579 . _:b482085572 . _:b482086382 . _:b482084761 "2"^^ . _:b482085573 . _:b482085574 . _:b482085575 . _:b482085568 . _:b482086377 . _:b482084760 "2"^^ . _:b482085569 . _:b482085570 . _:b482084814 . _:b482085571 . _:b482084712 . _:b482085596 . _:b482086376 . _:b482084763 "2"^^ . _:b482085597 . . . _:b482085598 . _:b482085599 . _:b482086449 . _:b482085592 . _:b482086379 . _:b482085578 . _:b482084762 "2"^^ . _:b482085593 . _:b482085594 . _:b482085595 . _:b482085588 . _:b482086378 . _:b482084773 "2"^^ . _:b482085589 . _:b482085590 . _:b482085591 . . _:b482086389 . _:b482085584 . _:b482084772 "2"^^ . _:b482085585 . _:b482085586 . _:b482085587 . _:b482085612 . _:b482086388 . _:b482084775 "2"^^ . _:b482085725 . _:b482085613 . _:b482085614 . _:b482085615 . _:b482085033 . _:b482085608 . _:b482086391 . _:b482084774 "2"^^ . _:b482085609 . _:b482085610 . _:b482085611 . _:b482085604 . _:b482086390 . . _:b482085605 . _:b482084769 "2"^^ . . _:b482085606 . _:b482085607 . _:b482085600 . _:b482086385 . _:b482084768 "2"^^ . _:b482085601 . _:b482085602 . _:b482084558 . _:b482085603 . . _:b482085628 . _:b482086384 . _:b482084771 "2"^^ . _:b482085629 . _:b482085630 . _:b482085631 . _:b482085624 . _:b482086387 . _:b482084770 "2"^^ . _:b482085625 . _:b482085626 . . _:b482085627 . _:b482085620 . _:b482086386 . _:b482083869 . _:b482085621 . _:b482084781 "2"^^ . _:b482085622 . _:b482085623 . _:b482085616 . _:b482086397 . _:b482084780 "2"^^ . _:b482085617 . _:b482085618 . _:b482085619 . _:b482085644 . _:b482086396 . _:b482084783 "2"^^ . _:b482085645 . _:b482084530 . _:b482085646 . _:b482085647 . . _:b482086399 . _:b482085640 . _:b482084782 "2"^^ . _:b482085641 . . _:b482085107 . _:b482085642 . _:b482085643 . _:b482086087 . _:b482085636 . _:b482086398 . _:b482084777 "2"^^ . _:b482085637 . _:b482085638 . . _:b14077308 . _:b482085639 . . _:b482086393 . _:b482085632 . . _:b482085633 . _:b482084776 "2"^^ . _:b482085634 . _:b482085635 . _:b482085660 . _:b482086392 . _:b482084779 "2"^^ . _:b482085661 . _:b482085662 . _:b482085663 . _:b482085656 . _:b482086395 . . _:b482085657 . _:b482084778 "2"^^ . _:b482085658 . _:b482085659 . _:b482085652 . _:b482086394 . _:b482084789 "2"^^ . _:b482085653 . _:b482084034 . _:b482085654 . _:b482085655 . _:b482085648 . _:b482085893 . _:b482084452 . _:b482085111 . _:b482085649 . _:b482084788 "2"^^ . _:b482085650 . _:b482085651 . _:b482085676 . _:b482085892 . _:b482084791 "2"^^ . _:b482085677 . _:b482085678 . _:b482085679 . _:b482085672 . _:b482085895 . _:b482084790 "2"^^ . _:b482085673 . _:b482085674 . . _:b482085675 . _:b482085668 . _:b482085894 . _:b482084785 "2"^^ . _:b482085669 . _:b482085670 . _:b482085671 . _:b482085664 . _:b482085889 . _:b482084784 "2"^^ . _:b482085665 . _:b482085666 . _:b482085667 . _:b482085692 . _:b482085888 . _:b482084787 "2"^^ . _:b482085693 . _:b482085694 . _:b482085695 . _:b482084522 . _:b482085891 . _:b482085571 . _:b482085688 . _:b482084786 "2"^^ . _:b482085689 . _:b482085690 . _:b482085691 . _:b482085684 . _:b482085890 . _:b482084797 "2"^^ . _:b482085685 . _:b482085686 . _:b482085891 . _:b482085687 . _:b482085680 . _:b482085901 . _:b482084796 "2"^^ . _:b482085681 . _:b482085682 . _:b482085683 . _:b482085708 . _:b482085900 . _:b482084799 "2"^^ . _:b482085709 . _:b482085710 . _:b482084851 . _:b482085711 . _:b482085704 . _:b482085903 . _:b482084798 "2"^^ . _:b482085705 . _:b482085706 . _:b482085707 . _:b482085700 . _:b482085902 . _:b482084793 "2"^^ . _:b482085701 . _:b482085702 . _:b482086214 . _:b482085703 . _:b482084950 . _:b482083757 . _:b482085897 . _:b482085696 . _:b482084792 "2"^^ . _:b482085697 . _:b482085698 . _:b482085699 . _:b482085724 . _:b482085896 . _:b482084795 "2"^^ . _:b482085725 . _:b482085726 . _:b482085727 . _:b482085257 . _:b482085720 . _:b482085899 . _:b482084794 "2"^^ . _:b482085721 . _:b482085722 . _:b482085723 . _:b482085716 . _:b482085898 . _:b482084805 "2"^^ . _:b482085717 . . _:b482085718 . _:b482084299 . _:b482085719 . _:b482085712 . _:b482085909 . _:b482084804 "2"^^ . _:b482085713 . _:b482085714 . _:b482085497 . _:b482085715 . _:b482085740 . _:b482085908 . _:b482084807 "2"^^ . _:b482085741 . _:b482085742 . _:b482085743 . _:b482085736 . _:b482085911 . _:b482084806 "2"^^ . _:b482085737 . . _:b482085738 . _:b482085808 . _:b482085739 . _:b482085732 . _:b482085910 . _:b482084801 "2"^^ . _:b482085733 . _:b482085734 . . _:b482085735 . . _:b482086523 . _:b482085905 . _:b482085728 . _:b482084800 "2"^^ . _:b482085729 . _:b482085730 . _:b482085731 . _:b482085756 . _:b482085904 . _:b482084803 "2"^^ . _:b482085757 . _:b482084326 . _:b482085758 . . _:b482085759 . _:b482085752 . _:b482085907 . _:b482084802 "2"^^ . _:b482085753 . _:b482084405 . _:b482085754 . _:b482085755 . _:b482083762 . _:b482085906 . _:b482085748 . _:b482084813 "2"^^ . _:b482085749 . . _:b482085750 . . . _:b482085751 . _:b482085744 . _:b482085917 . . _:b482085745 . _:b482084812 "2"^^ . _:b482085746 . _:b482086313 . _:b482085747 . _:b482085772 . _:b482085916 . _:b482084815 "2"^^ . _:b482085773 . _:b482085774 . . _:b482085775 . _:b482085768 . _:b482085919 . _:b482084814 "2"^^ . _:b482085769 . _:b482085770 . _:b482085771 . _:b482085764 . _:b482085918 . . _:b482085765 . _:b482084809 "2"^^ . . _:b482085766 . _:b482085767 . _:b482085760 . _:b482085913 . _:b482084808 "2"^^ . _:b482085761 . _:b482085762 . _:b482085763 . _:b482085788 . _:b482085912 . _:b482084811 "2"^^ . _:b482085789 . _:b482084563 . _:b482085790 . . . _:b482085791 . _:b482085784 . _:b482085915 . _:b482084810 "2"^^ . _:b482085785 . _:b482085786 . _:b482085787 . _:b482085780 . _:b482085914 . _:b482084821 "2"^^ . _:b482085781 . _:b482085782 . _:b482083454 . _:b482085783 . _:b482085776 . _:b482085925 . _:b482084820 "2"^^ . _:b482085777 . _:b482085778 . _:b482083695 . _:b482085955 . _:b482085779 . _:b482085804 . _:b482085924 . _:b482084823 "2"^^ . _:b482085805 . _:b482085806 . _:b482085807 . _:b482085800 . _:b482085927 . _:b482084822 "2"^^ . _:b482085801 . . _:b482085802 . _:b482085803 . _:b482085796 . _:b482085926 . _:b482084817 "2"^^ . _:b482085797 . _:b482085798 . _:b482085799 . _:b482085792 . _:b482085921 . . _:b482085793 . _:b482084816 "2"^^ . _:b482085794 . _:b482085795 . . _:b482085920 . _:b482085820 . _:b482084819 "2"^^ . _:b482085821 . . _:b482085822 . _:b482085823 . _:b482085816 . _:b482085923 . _:b482084818 "2"^^ . _:b482085817 . _:b482085818 . _:b482085819 . _:b482085812 . _:b482085922 . . _:b482085813 . _:b482084829 "2"^^ . _:b482085814 . _:b482085815 . _:b482085808 . _:b482085933 . _:b482084828 "2"^^ . _:b482085809 . _:b482085810 . _:b482085811 . . _:b482085932 . _:b482085836 . _:b482084831 "2"^^ . _:b482085837 . _:b482084373 . _:b482085838 . _:b482084799 . _:b482085839 . _:b482085832 . _:b482085935 . _:b482084830 "2"^^ . _:b482085833 . _:b482085834 . _:b482085835 . _:b482085420 . _:b482085828 . _:b482085934 . _:b482085604 . _:b482084825 "2"^^ . _:b482085829 . _:b482085830 . _:b482085831 . _:b482085824 . _:b482085929 . _:b482084824 "2"^^ . _:b482085825 . _:b482085826 . _:b482085827 . _:b482085852 . _:b482085928 . _:b482083811 . _:b482085853 . _:b482084827 "2"^^ . . _:b482085854 . _:b482085855 . _:b482085848 . _:b482085931 . _:b482083937 . _:b482085849 . _:b482084826 "2"^^ . _:b482085850 . _:b482085851 . _:b482085844 . _:b482085930 . _:b482084837 "2"^^ . _:b482085845 . _:b482085846 . _:b482084166 . _:b482085847 . _:b482085840 . _:b482085941 . _:b482084836 "2"^^ . _:b482085841 . _:b482084550 . _:b482085842 . _:b482085843 . _:b482085868 . _:b482085940 . _:b482084839 "2"^^ . _:b482085869 . _:b482085870 . _:b482085871 . _:b482085864 . _:b482085943 . _:b482084838 "2"^^ . _:b482085865 . . _:b482085866 . _:b482085867 . _:b482085860 . _:b482085942 . _:b482084833 "2"^^ . _:b482085861 . _:b482085862 . _:b482085863 . _:b482085856 . _:b482085937 . _:b482084832 "2"^^ . _:b482085857 . _:b482085858 . _:b482085859 . _:b482085884 . _:b482085936 . _:b482084835 "2"^^ . _:b482085885 . _:b482085886 . _:b482085887 . _:b482085880 . _:b482085939 . _:b482084834 "2"^^ . _:b482085853 . _:b482085881 . . . _:b482085882 . . _:b482085883 . _:b482085876 . _:b482085938 . _:b482083489 . _:b482085877 . _:b482084845 "2"^^ . _:b482085878 . _:b482085879 . _:b482085872 . _:b482085949 . _:b482084844 "2"^^ . _:b482085873 . _:b482085874 . _:b482085875 . _:b482083890 . _:b482085948 . _:b482084876 . _:b482084847 "2"^^ . _:b482084877 . _:b482083689 . _:b482085034 . _:b482084878 . _:b482084879 . _:b482084872 . _:b482085951 . _:b482084846 "2"^^ . _:b482084873 . _:b482084874 . _:b482084875 . _:b482085165 . _:b482084868 . _:b482085950 . _:b482084841 "2"^^ . _:b482084869 . _:b482084870 . _:b482084871 . _:b482084864 . _:b482085945 . _:b482084840 "2"^^ . _:b482084865 . _:b482084866 . _:b482084867 . _:b482084892 . _:b482085944 . . _:b482084951 . _:b482084893 . _:b482084843 "2"^^ . _:b482084323 . _:b482084894 . _:b482084895 . _:b482084888 . _:b482085947 . . _:b482084842 "2"^^ . _:b482084889 . _:b482084890 . _:b482086529 . _:b482084891 . _:b482084884 . _:b482085946 . _:b482084853 "2"^^ . _:b482084885 . _:b482084886 . _:b482084887 . _:b482084880 . _:b482085957 . _:b482084852 "2"^^ . _:b482084881 . _:b482084882 . _:b482084883 . _:b482084908 . _:b482085956 . _:b482084855 "2"^^ . _:b482084909 . _:b482084910 . _:b482084911 . _:b482084904 . _:b14077298 "In addition to mutations in known AML genes such as DNMT3A8, FLT39, NPM110, IDH17, IDH211, WT112, RUNX113,14, PTPRT>>3<<, PHF615, and ETV616 in these 8 patients, we also discovered novel, recurring mutations in WAC, SMC3, DIS3, DDX41, and DAXX using 200 AML cases whose exomes were sequenced as part of the The Cancer Genome Atlas AML project (Table 1," . _:b482085959 . _:b482084854 "2"^^ . _:b482084905 . _:b482084906 . _:b482084907 . _:b482085001 . _:b482084900 . _:b482085958 . _:b482084849 "2"^^ . _:b482084901 . _:b482084902 . _:b482084903 . _:b482084896 . _:b482085953 . _:b482084848 "2"^^ . _:b482084897 . _:b482084898 . _:b482084899 . _:b482084924 . _:b482085952 . . _:b482084925 . _:b482084851 "2"^^ . _:b482084926 . _:b482084927 . _:b482084920 . _:b482085955 . _:b482084850 "2"^^ . _:b482084921 . _:b482084922 . _:b482084923 . _:b482084916 . _:b482085954 . _:b482084861 "2"^^ . _:b482084917 . _:b482084918 . _:b482084919 . _:b482084912 . _:b482085965 . _:b482085606 . _:b482084860 "2"^^ . _:b482084913 . _:b482084914 . _:b482084915 . . _:b482085964 . _:b482084940 . _:b482084863 "2"^^ . _:b482084941 . . _:b482084942 . _:b482083241 . _:b482084943 . _:b482084936 . _:b482085967 . _:b482084862 "2"^^ . _:b482084937 . _:b482084938 . _:b482083712 . _:b482084939 . . _:b482085966 . _:b482084932 . _:b482084857 "2"^^ . _:b482084933 . _:b482084934 . _:b482084935 . _:b482084928 . _:b482085961 . _:b482084856 "2"^^ . _:b482086470 . _:b482084929 . _:b482084930 . _:b482084931 . _:b482083223 . _:b482085960 . _:b482085463 . _:b482084956 . _:b482084859 "2"^^ . _:b482084957 . _:b482084958 . _:b482084959 . _:b482084952 . _:b482085963 . _:b482084858 "2"^^ . _:b482084953 . _:b482084954 . _:b482084955 . _:b482084948 . _:b482085962 . _:b482084949 . _:b482084950 . _:b482083845 "4"^^ . _:b482084951 . _:b482084944 . _:b482085973 . _:b482084945 . _:b482084946 . _:b482083844 "4"^^ . _:b482084947 . _:b482084972 . _:b482085972 . _:b482084973 . _:b482084974 . _:b482086171 . _:b482083847 "4"^^ . _:b482084975 . _:b482084968 . _:b482085975 . . _:b482084969 . . _:b482084970 . _:b482083846 "4"^^ . _:b482084971 . _:b482084964 . _:b482085974 . _:b482084965 . _:b482084966 . _:b482083841 "4"^^ . _:b482084967 . _:b482084960 . _:b482085969 . _:b482083792 . _:b482086502 . _:b482084961 . _:b482084962 . _:b482085189 . _:b482083840 "4"^^ . _:b482084963 . . _:b482085968 . _:b482084988 . _:b482084989 . _:b482084990 . . _:b482084991 . _:b482083843 "4"^^ . _:b482084984 . _:b14077286 "Candidate somatic events in the primary tumor and relapse genomes were identified4,>>5<< and selected for hybridization capture-based validation using methods described in Supplementary Information." . _:b482085971 . _:b482084985 . . _:b482084986 . _:b482083842 "4"^^ . _:b482084987 . _:b482083476 . _:b482085970 . _:b482084980 . _:b482084981 . _:b482084982 . _:b482084114 . _:b482084983 . _:b482083853 "4"^^ . . _:b482085981 . _:b482084976 . _:b482084977 . _:b482084978 . _:b482083852 "4"^^ . _:b482085386 . _:b482084979 . _:b482085004 . _:b482085980 . _:b482085005 . _:b482085006 . . _:b482085007 . _:b482083855 "4"^^ . _:b482085000 . _:b482085983 . _:b482085001 . _:b482085002 . _:b482083854 "4"^^ . _:b482085003 . . _:b482085982 . _:b482084996 . . _:b482084997 . . _:b482084998 . _:b482083849 "4"^^ . _:b482084999 . . _:b482085977 . _:b482084992 . _:b482084993 . _:b482084994 . _:b482083848 "4"^^ . _:b482084995 . _:b482085020 . _:b482085976 . _:b482085021 . _:b482085022 . _:b482084455 . . . _:b482085023 . _:b482083851 "4"^^ . _:b482085016 . _:b482085979 . . _:b482085017 . _:b482085018 . _:b482085019 . _:b482083850 "4"^^ . _:b482085012 . _:b482085978 . _:b482084811 . _:b482085013 . _:b482085014 . _:b482084319 . _:b482085015 . _:b482083861 "4"^^ . _:b482085008 . _:b482086290 . _:b482085989 . _:b482085009 . _:b482085010 . _:b482085011 . _:b482083860 "4"^^ . _:b482085036 . _:b482085988 . . _:b482085037 . _:b482084708 . _:b482085038 . _:b482085039 . _:b482083863 "4"^^ . _:b482085032 . _:b482085991 . _:b482085033 . _:b482085034 . _:b482085035 . _:b482083862 "4"^^ . _:b482085028 . _:b482085990 . _:b482085428 . _:b482085029 . _:b482085030 . . _:b482085031 . _:b482083857 "4"^^ . _:b482085024 . _:b482085985 . _:b482085025 . _:b482085026 . _:b482086126 . _:b482085060 . _:b482085027 . _:b482083856 "4"^^ . . _:b482085052 . _:b482085984 . _:b482085053 . . _:b482085054 . _:b482085055 . _:b482083859 "4"^^ . _:b482085048 . _:b482085987 . _:b482085632 . _:b482085049 . _:b482085050 . _:b482085051 . _:b482083858 "4"^^ . _:b482085044 . _:b482085986 . _:b482085045 . _:b482085046 . _:b482085047 . _:b482083869 "4"^^ . _:b482085040 . _:b482085997 . _:b482085373 . _:b482085041 . _:b482085042 . _:b482085043 . _:b482083868 "4"^^ . _:b482083491 . _:b482085068 . _:b482085996 . . _:b482085069 . . _:b482085070 . _:b482084505 . _:b482085071 . _:b482083871 "4"^^ . _:b482085064 . _:b482085999 . _:b482085065 . _:b482085066 . . _:b482085067 . _:b482083870 "4"^^ . _:b482085060 . _:b482085998 . _:b482085061 . _:b482085525 . _:b482085062 . _:b482085063 . _:b482083865 "4"^^ . _:b482085056 . _:b482085993 . _:b482085057 . _:b482085058 . _:b482085059 . _:b482083864 "4"^^ . _:b482085084 . _:b482085992 . _:b482085085 . _:b482084459 . . _:b482085086 . _:b482085087 . _:b482083867 "4"^^ . _:b482085080 . _:b482086183 . _:b482085995 . _:b482085081 . _:b482085893 . _:b482085082 . _:b482085735 . _:b482085083 . _:b482083866 "4"^^ . _:b482085076 . _:b482085994 . _:b482085077 . _:b482084676 . _:b482085078 . . _:b482083877 "4"^^ . _:b482085079 . _:b482085072 . _:b482086278 . _:b482086005 . _:b482085073 . _:b482085074 . . _:b482085075 . _:b482083876 "4"^^ . _:b482085100 . _:b482086004 . _:b482085101 . _:b482085102 . _:b482085103 . _:b482083879 "4"^^ . . _:b482085096 . _:b482086007 . . _:b482085097 . . _:b482085098 . . _:b482085099 . _:b482083878 "4"^^ . _:b482085092 . _:b482086006 . . _:b482085093 . _:b482085094 . _:b482085095 . _:b482083873 "4"^^ . _:b482085088 . _:b482086001 . _:b482085089 . _:b482085090 . _:b482085091 . _:b482083872 "4"^^ . _:b482085116 . _:b482086000 . _:b482085117 . _:b482085118 . _:b482085119 . _:b482086362 . _:b482085363 . _:b482083875 "4"^^ . _:b482085112 . _:b482086003 . _:b482083399 . _:b482085113 . _:b482085114 . _:b482086547 . _:b482085115 . _:b482085652 . _:b482083874 "4"^^ . _:b482084352 . _:b482085108 . _:b482086002 . _:b482085109 . _:b482085110 . . 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"4"^^ . _:b482085364 . _:b482086066 . _:b482085365 . _:b482085366 . _:b482085367 . . _:b482083949 "4"^^ . _:b482085360 . _:b482086077 . _:b482085361 . _:b482085362 . _:b482085363 . _:b482083948 "4"^^ . _:b482086412 . _:b482086076 . _:b482086413 . _:b482086414 . _:b482086415 . _:b482083951 "4"^^ . _:b482086408 . _:b482086079 . . _:b482086409 . _:b482086410 . _:b482085666 . _:b482083974 . _:b482086411 . _:b482083950 "4"^^ . _:b482086404 . _:b482086093 . _:b482086078 . _:b482086405 . _:b482086406 . _:b482086407 . _:b482085656 . _:b482083945 "4"^^ . _:b482086400 . _:b482086073 . _:b482086401 . _:b482086402 . _:b482086403 . _:b482083944 "4"^^ . _:b482084151 . _:b482086428 . _:b482086072 . _:b482086429 . _:b482086430 . _:b482086431 . _:b482083947 "4"^^ . _:b482086424 . _:b482086075 . _:b482086425 . _:b482084399 . _:b482086426 . _:b482086427 . _:b482083946 "4"^^ . _:b482086420 . _:b482086074 . _:b482086421 . _:b482086422 . _:b482086423 . _:b482083957 "4"^^ . _:b482083823 . _:b482084225 . 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_:b482085470 . _:b482083338 "9"^^ . _:b482085465 . . _:b482085464 . _:b482083339 "9"^^ . _:b482083337 "10"^^ . _:b482083781 . _:b482085467 . _:b482083336 "10"^^ . _:b482085466 . _:b482083350 "9"^^ . _:b482085477 . . _:b482083351 "9"^^ . _:b482085476 . _:b482083348 "9"^^ . _:b482085479 . . _:b482085719 . _:b482083451 . _:b482085478 . _:b482083349 "9"^^ . _:b482083346 "9"^^ . _:b482085473 . _:b482084869 . _:b482083347 "9"^^ . _:b482085472 . _:b482085515 . _:b482083344 "9"^^ . _:b482085475 . _:b482083345 "9"^^ . _:b482085474 . _:b482083358 "9"^^ . _:b482085485 . . _:b482083359 "9"^^ . _:b482085484 . _:b482083356 "9"^^ . _:b482085487 . . _:b482085486 . _:b482083357 "9"^^ . _:b482085266 . _:b482083354 "9"^^ . _:b482085481 . _:b482084229 . _:b482083355 "9"^^ . _:b482085480 . _:b482085422 . _:b14077312 . _:b482083352 "9"^^ . _:b482085483 . _:b482084087 . _:b482083568 . _:b482085482 . _:b482083353 "9"^^ . _:b482083366 "9"^^ . _:b482085493 . _:b482085316 . _:b482083367 "9"^^ . _:b482085492 . _:b482084805 . _:b482083671 . _:b482083364 "9"^^ . _:b482086390 . _:b482085495 . _:b482083336 . _:b482085174 . _:b482083365 "9"^^ . _:b482085494 . _:b482083362 "9"^^ . _:b482085489 . _:b482083363 "9"^^ . _:b482085488 . . _:b482083360 "9"^^ . _:b482085491 . . _:b482085490 . _:b482083361 "9"^^ . _:b482085801 . _:b482083374 "8"^^ . . _:b482085501 . . . . _:b482084110 . _:b482083375 "8"^^ . _:b482085500 . . _:b482085503 . _:b482083372 "9"^^ . . _:b482083373 "9"^^ . _:b482085502 . _:b482084429 . _:b482083370 "9"^^ . _:b482085497 . . _:b482085787 . . _:b482085496 . _:b482083371 "9"^^ . _:b482083368 "9"^^ . _:b482085499 . . _:b482083369 "9"^^ . _:b482085498 . . . _:b482083382 "8"^^ . _:b482085509 . _:b482083383 "8"^^ . _:b482085508 . . _:b482083380 "8"^^ . _:b482085511 . _:b482083381 "8"^^ . . _:b482085510 . _:b482083378 "8"^^ . _:b482085505 . . . _:b482083379 "8"^^ . . _:b482086505 . _:b482085504 . _:b482085079 . _:b482084033 . _:b482083376 "8"^^ . _:b482085625 . _:b482085507 . _:b482083377 "8"^^ . _:b482083558 . _:b482085506 . _:b482083390 "8"^^ . _:b482085517 . . _:b482083391 "8"^^ . _:b482085516 . _:b482083388 "8"^^ . _:b482085519 . . _:b482083389 "8"^^ . _:b482085518 . . _:b482083386 "8"^^ . _:b482085513 . _:b482084618 . _:b482083387 "8"^^ . _:b482085512 . . . . _:b482083384 "8"^^ . . _:b482085515 . _:b482083692 . _:b482083385 "8"^^ . _:b482085514 . . _:b482086147 . _:b482083398 "8"^^ . . _:b482085525 . _:b482083936 . _:b482083399 "8"^^ . _:b482085524 . . _:b482083396 "8"^^ . _:b482085395 . _:b482085527 . _:b482083397 "8"^^ . _:b482085526 . _:b482083394 "8"^^ . _:b482085521 . . . _:b482083395 "8"^^ . _:b482085520 . _:b482083392 "8"^^ . . _:b482085523 . _:b482083393 "8"^^ . _:b482085522 . _:b482083406 "8"^^ . . _:b482085533 . . . _:b482083407 "8"^^ . _:b482085532 . _:b482083404 "8"^^ . _:b482085535 . . _:b482083405 "8"^^ . _:b482085534 . . _:b482083402 "8"^^ . _:b482083744 . _:b482085529 . _:b482083403 "8"^^ . _:b482085528 . _:b482086063 . . _:b482083400 "8"^^ . _:b482085531 . _:b482086185 . _:b482083401 "8"^^ . _:b482085530 . . _:b482083414 "8"^^ . _:b482085541 . _:b482085629 . _:b482083415 "8"^^ . _:b482085540 . _:b482083412 "8"^^ . _:b482085543 . _:b482083413 "8"^^ . _:b482085542 . _:b482085333 . _:b482086120 . _:b482085006 . _:b482083410 "8"^^ . _:b482084419 . _:b482085537 . _:b482083181 . _:b482083411 "8"^^ . . _:b482085536 . _:b482083408 "8"^^ . _:b482085539 . _:b482086015 . . _:b482083409 "8"^^ . . _:b482085538 . _:b482084396 . _:b482083422 "8"^^ . . _:b482085549 . _:b482083423 "8"^^ . _:b482085548 . _:b482084999 . _:b482083420 "8"^^ . _:b482085551 . . . _:b482083421 "8"^^ . _:b482084487 . _:b482085550 . . _:b482083418 "8"^^ . . _:b482085545 . . . _:b482083419 "8"^^ . _:b482083528 . _:b482085544 . _:b482083746 . _:b482083416 "8"^^ . . _:b482085547 . . _:b482083417 "8"^^ . _:b482085546 . _:b482083430 "7"^^ . _:b482085557 . _:b482083431 "7"^^ . . _:b482085556 . _:b482083428 "7"^^ . _:b482085559 . _:b482086304 . . _:b482083429 "7"^^ . _:b482085558 . . . _:b482083426 "7"^^ . . _:b482085553 . . _:b482083427 "7"^^ . _:b482084556 . _:b482085552 . _:b482085930 . _:b482083424 "7"^^ . _:b482086473 . . _:b482085555 . . _:b482083425 "7"^^ . _:b482083945 . _:b482086157 . _:b482083585 . _:b482085554 . _:b482084611 . . _:b482083438 "7"^^ . . _:b482085565 . _:b482083817 . _:b482083439 "7"^^ . _:b482085564 . . _:b482083436 "7"^^ . _:b482086263 . _:b482085567 . _:b482083437 "7"^^ . _:b482085566 . _:b482083434 "7"^^ . _:b482085561 . _:b482086228 . _:b482083435 "7"^^ . . _:b482085560 . _:b482083432 "7"^^ . _:b482085622 . _:b482085563 . _:b482083686 . _:b482083433 "7"^^ . _:b482085562 . . _:b482083446 "7"^^ . _:b482085135 . _:b482085573 . _:b482083447 "7"^^ . _:b482085572 . . _:b482083444 "7"^^ . _:b482085575 . _:b482083445 "7"^^ . _:b482085574 . _:b482083442 "7"^^ . _:b482085569 . _:b482083443 "7"^^ . _:b482084664 . _:b482085568 . . _:b482083440 "7"^^ . _:b482085571 . . _:b482083441 "7"^^ . _:b482084508 . _:b482085570 . _:b482083454 "7"^^ . . _:b482086040 . _:b482085581 . . _:b482083455 "7"^^ . _:b482085580 . _:b482083452 "7"^^ . _:b482085583 . _:b482083525 . _:b482083453 "7"^^ . _:b482085582 . . _:b482083450 "7"^^ . . _:b482085817 . _:b482085577 . _:b482083451 "7"^^ . _:b482085576 . _:b482084002 . _:b482083448 "7"^^ . _:b482085579 . . _:b482083449 "7"^^ . _:b482085132 . _:b482085578 . _:b482084285 . _:b482083462 "7"^^ . _:b482084544 . _:b482083765 . _:b482085589 . . . _:b482083463 "7"^^ . . _:b482085588 . _:b482083460 "7"^^ . _:b482083211 . _:b482085591 . . . _:b482083461 "7"^^ . _:b482083818 . _:b482085590 . _:b482083655 . _:b482083458 "7"^^ . _:b482085585 . . . _:b482083459 "7"^^ . . _:b482085584 . _:b482083456 "7"^^ . _:b482085387 . _:b482085587 . _:b482083457 "7"^^ . _:b482085586 . _:b482083470 "7"^^ . _:b482083418 . _:b482085597 . _:b482083471 "7"^^ . _:b482085596 . _:b482086485 . _:b482083468 "7"^^ . _:b482085599 . _:b482083469 "7"^^ . . _:b482085598 . _:b482083606 . _:b482083466 "7"^^ . _:b482085593 . _:b482083467 "7"^^ . _:b482085592 . _:b482083464 "7"^^ . _:b482085595 . . _:b482083465 "7"^^ . . _:b482085594 . _:b482083478 "7"^^ . . _:b482085605 . _:b482084057 . _:b482083479 "7"^^ . _:b482085028 . . _:b482085371 . _:b482085604 . . _:b482085736 . _:b482083476 "7"^^ . _:b482085607 . _:b482083477 "7"^^ . . _:b482085606 . . _:b482083474 "7"^^ . _:b482085601 . _:b482083475 "7"^^ . _:b482085532 . . _:b482085600 . . _:b482083472 "7"^^ . . _:b482085603 . _:b482083473 "7"^^ . . _:b482085602 . _:b482083486 "7"^^ . _:b482085875 . . _:b482085613 . _:b14077300 . _:b482083487 "7"^^ . _:b482086333 . _:b482083245 . _:b482083304 . _:b482085612 . . _:b482083484 "7"^^ . _:b482086538 . _:b482085615 . . _:b482083485 "7"^^ . . _:b482085614 . _:b482083482 "7"^^ . . . _:b482085609 . _:b482084318 . _:b482083483 "7"^^ . _:b482085186 . _:b482085608 . _:b482083480 "7"^^ . _:b482085611 . _:b482083481 "7"^^ . _:b482085472 . _:b482085610 . _:b482085412 . _:b482083494 "7"^^ . _:b482085621 . _:b482083495 "7"^^ . . _:b482083441 . _:b482085620 . _:b482083492 "7"^^ . . _:b482085623 . _:b482083493 "7"^^ . . . . _:b482085622 . _:b482083490 "7"^^ . _:b482085617 . _:b482083491 "7"^^ . _:b482085616 . _:b482083488 "7"^^ . . _:b482085619 . _:b482083489 "7"^^ . _:b482085618 . _:b482083502 "6"^^ . . _:b482085629 . _:b482083503 "6"^^ . _:b482085617 . _:b482085662 . _:b482085628 . _:b482083500 "6"^^ . _:b482085631 . _:b482083501 "6"^^ . _:b482084184 . _:b482085561 . _:b482085630 . _:b482083498 "6"^^ . . _:b482083921 . _:b482085625 . _:b482083499 "6"^^ . _:b482086166 . _:b482085624 . _:b482083496 "6"^^ . _:b482084025 . . _:b482085024 . _:b482085627 . _:b482083497 "6"^^ . . _:b482086116 . _:b482085626 . _:b482083510 "6"^^ . . _:b482085125 . _:b482083511 "6"^^ . _:b14077301 "and C:G->G:C (P = 0.00366) transversions, respectively, in relapse-specific mutations; of note, increased A:T->C:G transversion rate has also been observed in cases of chronic lymphocytic leukemia with mutated immunoglobulin genes>>17<<. C:G->A:T transversions are the most common mutation in lung cancer patients who were exposed to tobacco-borne carcinogens18 (Fig." . . _:b482085124 . _:b482083508 "6"^^ . _:b482085127 . _:b482083509 "6"^^ . _:b482083951 . _:b482085126 . _:b482086347 . _:b482083506 "6"^^ . . . . _:b482086186 . _:b482083517 . _:b482085121 . _:b482083507 "6"^^ . _:b482085120 . _:b482083504 "6"^^ . . _:b482085123 . _:b482083505 "6"^^ . . . _:b482085122 . _:b482083518 "6"^^ . _:b14077286 . _:b482085133 . _:b482083519 "6"^^ . _:b482085830 . . _:b482085132 . _:b482083516 "6"^^ . _:b482086032 . _:b482085135 . _:b482083517 "6"^^ . _:b482085144 . . _:b482085264 . _:b482085134 . _:b482083514 "6"^^ . _:b482086145 . _:b482085194 . . _:b482085129 . _:b482083515 "6"^^ . _:b482085128 . _:b482083512 "6"^^ . _:b482085131 . _:b482083513 "6"^^ . _:b482083515 . . . _:b482085130 . _:b482083526 "6"^^ . . _:b482085041 . _:b482085141 . _:b482083527 "6"^^ . _:b482086266 . _:b482084498 . _:b482085140 . _:b482085764 . _:b482083524 "6"^^ . . . _:b482083721 . _:b482085143 . _:b482083525 "6"^^ . _:b482085142 . _:b482083522 "6"^^ . _:b482085137 . _:b482083523 "6"^^ . . _:b482085136 . _:b482083520 "6"^^ . . . . _:b482085139 . _:b482083994 . _:b482083642 . _:b482083521 "6"^^ . . _:b482085138 . _:b482083534 "6"^^ . _:b482086084 . _:b482085471 . _:b482085149 . _:b482083535 "6"^^ . _:b482084966 . _:b482086060 . _:b482085148 . _:b482083532 "6"^^ . _:b482085151 . _:b482083533 "6"^^ . . _:b482085150 . _:b482083530 "6"^^ . _:b482085145 . _:b482083531 "6"^^ . . _:b482083950 . _:b482085144 . _:b482083528 "6"^^ . . . _:b482085147 . _:b482083529 "6"^^ . . _:b482083930 . _:b482085146 . _:b482083542 "6"^^ . _:b482083711 . _:b482086354 . _:b482085157 . _:b482083543 "6"^^ . _:b482085156 . _:b482083540 "6"^^ . _:b482085153 . _:b482084693 . . . _:b482085159 . _:b482085093 . _:b482083541 "6"^^ . . _:b482085158 . _:b482083538 "6"^^ . _:b482085989 . _:b482085153 . _:b482083539 "6"^^ . _:b482084551 . _:b482084067 . _:b482085152 . _:b482083536 "6"^^ . _:b482085155 . _:b482083537 "6"^^ . . _:b482085154 . _:b482083550 "6"^^ . _:b482083562 . . _:b482085165 . _:b482083551 "6"^^ . _:b482083776 . . _:b482086103 . . _:b482085164 . _:b482086127 . _:b482083548 "6"^^ . . _:b482083704 . . _:b482085167 . _:b482083549 "6"^^ . _:b482084825 . _:b482085166 . _:b482083546 "6"^^ . . . _:b482086143 . . _:b482085161 . _:b482083547 "6"^^ . _:b482085160 . _:b482083544 "6"^^ . . . _:b482085163 . _:b482083545 "6"^^ . . . _:b482085162 . _:b482083558 "6"^^ . _:b482083963 . _:b482085173 . _:b482083559 "6"^^ . _:b482083306 . _:b482085172 . _:b482083556 "6"^^ . . _:b482083551 . _:b482085175 . _:b482083557 "6"^^ . _:b482083697 . _:b482085174 . _:b482083554 "6"^^ . . . _:b482085169 . _:b482083555 "6"^^ . _:b482085936 . _:b482085168 . _:b482083552 "6"^^ . _:b482085171 . _:b482083553 "6"^^ . _:b482085170 . _:b482083566 "6"^^ . _:b482083707 . _:b482085181 . _:b482083567 "6"^^ . . _:b482085180 . _:b482083564 "6"^^ . _:b482085183 . _:b482083565 "6"^^ . _:b482083402 . . . _:b482085182 . _:b482083562 "6"^^ . _:b482083352 . . _:b482085177 . _:b482083563 "6"^^ . . _:b482085176 . _:b482083560 "6"^^ . . _:b482085179 . _:b482083561 "6"^^ . _:b14077295 "In addition to mutations in known AML genes such as DNMT3A8, FLT39, NPM110, IDH17, IDH211, WT>>112<<, RUNX113,14, PTPRT3, PHF615, and ETV616 in these 8 patients, we also discovered novel, recurring mutations in WAC, SMC3, DIS3, DDX41, and DAXX using 200 AML cases whose exomes were sequenced as part of the The Cancer Genome Atlas AML" . _:b482086372 . _:b482085178 . _:b482085322 . _:b482083574 "6"^^ . . _:b482085189 . _:b482083575 "6"^^ . _:b482085188 . _:b482083572 "6"^^ . _:b482084616 . _:b482085191 . _:b482083573 "6"^^ . . . _:b482085031 . _:b482085190 . _:b482083570 "6"^^ . _:b482085381 . _:b482085185 . _:b482083571 "6"^^ . _:b482085184 . _:b482083568 "6"^^ . _:b482086466 . . _:b482085187 . _:b482083569 "6"^^ . . _:b482085186 . _:b482083582 "6"^^ . _:b482085197 . _:b482083583 "6"^^ . _:b482085196 . _:b482083580 "6"^^ . . _:b482085199 . _:b482083581 "6"^^ . _:b482085198 . _:b482083578 "6"^^ . _:b482085193 . _:b482083579 "6"^^ . _:b482085192 . _:b482083576 "6"^^ . . _:b482085195 . _:b482083577 "6"^^ . _:b482086275 . _:b482085194 . _:b482083589 "5"^^ . _:b482085205 . _:b482084039 . . . _:b482085204 . _:b482083588 "6"^^ . . _:b482083591 "5"^^ . _:b482085207 . _:b482083590 "5"^^ . _:b482085206 . _:b482083586 "6"^^ . . . . _:b482085201 . _:b482083587 "6"^^ . . _:b482085200 . _:b482085753 . _:b482083584 "6"^^ . _:b482085582 . _:b482085203 . _:b482083585 "6"^^ . _:b482085202 . . _:b482086446 . _:b482083597 "5"^^ . _:b482085213 . _:b482084905 . _:b482083596 "5"^^ . _:b482085212 . . _:b482083599 "5"^^ . _:b482085215 . _:b482083992 . _:b482083598 "5"^^ . _:b482085214 . . _:b482083593 "5"^^ . _:b482085209 . _:b482086098 . . _:b482083592 "5"^^ . _:b482085208 . _:b482083392 . _:b482083595 "5"^^ . _:b482085211 . _:b482084707 . _:b482083594 "5"^^ . _:b482085210 . _:b482086549 . _:b482083605 "5"^^ . _:b482085221 . _:b482083814 . _:b482083604 "5"^^ . _:b482085220 . _:b482083971 . _:b482084919 . _:b482085924 . _:b482083607 "5"^^ . _:b482085223 . _:b482083606 "5"^^ . _:b482085222 . _:b482084504 . _:b482083601 "5"^^ . _:b482085217 . _:b482083600 "5"^^ . _:b482085216 . _:b482083603 "5"^^ . _:b482085219 . . _:b482085507 . _:b482083602 "5"^^ . _:b482085268 . _:b482085218 . _:b482083613 "5"^^ . _:b482085229 . _:b482083345 . . _:b482083612 "5"^^ . _:b482085228 . . _:b482083615 "5"^^ . _:b482085231 . _:b14077312 "Structural variations were identified using BreakDancer>>5<<. All predicted non-repetitive somatic SNVs, indels, and all structural variants were included on custom sequence capture arrays from Roche Nimblegen." . . _:b482085880 . _:b482083614 "5"^^ . _:b482085230 . _:b482083609 "5"^^ . _:b482085225 . . _:b482083608 "5"^^ . _:b482085224 . . _:b482084807 . _:b482083611 "5"^^ . _:b482085227 . . . _:b482083610 "5"^^ . _:b482085226 . . _:b482083621 "5"^^ . _:b482085237 . _:b482085511 . . _:b482084643 . _:b482083620 "5"^^ . _:b482085236 . . _:b482086423 . _:b482086243 . _:b482083623 "5"^^ . _:b482085239 . . _:b482085238 . _:b482083622 "5"^^ . _:b482083714 . . _:b482083617 "5"^^ . _:b482085233 . . _:b482084529 . _:b482083616 "5"^^ . _:b482085232 . _:b482084566 . _:b482083619 "5"^^ . _:b482085235 . _:b482083618 "5"^^ . _:b482085234 . . _:b482083629 "5"^^ . _:b482085245 . _:b482083628 "5"^^ . _:b482085244 . _:b482084564 . _:b482083631 "5"^^ . _:b482085247 . _:b482084615 . _:b482083630 "5"^^ . _:b482085246 . _:b482085244 . . _:b482083625 "5"^^ . _:b482085241 . . . _:b482083624 "5"^^ . _:b482085240 . _:b482083627 "5"^^ . _:b482085243 . _:b482083382 . _:b482083626 "5"^^ . _:b482085242 . _:b482083850 . _:b482083637 "5"^^ . _:b482085253 . . _:b482083636 "5"^^ . _:b482085252 . _:b482083639 "5"^^ . _:b482085255 . _:b482084567 . _:b482083638 "5"^^ . _:b482085254 . _:b482083633 "5"^^ . _:b482085249 . _:b482083632 "5"^^ . _:b482085248 . . _:b482084770 . _:b482083635 "5"^^ . _:b482085251 . _:b482084596 . _:b482083634 "5"^^ . _:b482085607 . _:b482085250 . _:b482085491 . _:b482084957 . _:b482083645 "5"^^ . _:b482085261 . _:b482083856 . . . _:b482083644 "5"^^ . _:b482085260 . . _:b482083647 "5"^^ . _:b482085263 . _:b482083646 "5"^^ . _:b482085262 . _:b482083837 . _:b482086254 . _:b482083641 "5"^^ . _:b482085257 . _:b482083640 "5"^^ . _:b482085256 . _:b482083281 . _:b482083643 "5"^^ . _:b482085259 . . _:b482085661 . _:b482083642 "5"^^ . _:b482085258 . _:b482083753 . _:b482084574 . _:b482083653 "5"^^ . _:b482085269 . _:b482085240 . . _:b482083314 . _:b482083652 "5"^^ . _:b482085268 . _:b482085123 . _:b482086406 . . . _:b482083655 "5"^^ . _:b482085271 . _:b482083997 . _:b482083654 "5"^^ . _:b482085270 . _:b482084562 . _:b482085747 . _:b482083649 "5"^^ . _:b482085265 . _:b482084586 . _:b482085935 . _:b482083648 "5"^^ . _:b482085520 . _:b482085264 . _:b482083347 . _:b482083651 "5"^^ . _:b482085267 . _:b482084527 . _:b482083650 "5"^^ . _:b482085266 . . _:b482083661 "5"^^ . _:b482085277 . . . _:b482083660 "5"^^ . _:b482085276 . . . _:b482083663 "5"^^ . _:b482085279 . . . _:b482083662 "5"^^ . _:b482085278 . . _:b482083657 "5"^^ . _:b482085273 . . _:b482083656 "5"^^ . _:b482085272 . _:b482083659 "5"^^ . _:b482085275 . _:b482083736 . _:b482083520 . . _:b482083658 "5"^^ . _:b482085274 . _:b482084312 . . _:b482083669 "5"^^ . _:b482085285 . . _:b482083668 "5"^^ . _:b482085284 . . . _:b482083671 "5"^^ . _:b482085287 . _:b482083670 "5"^^ . _:b482085286 . _:b482083665 "5"^^ . _:b482085605 . _:b482085281 . . _:b482083749 . _:b482083664 "5"^^ . _:b482085280 . . _:b482083567 . _:b482083667 "5"^^ . _:b482085283 . . _:b482085391 . _:b482084205 . _:b482083666 "5"^^ . _:b482085282 . . _:b482083677 "5"^^ . _:b482085293 . _:b482083184 . _:b482083676 "5"^^ . _:b482085292 . _:b482083679 "5"^^ . _:b482085295 . _:b482083678 "5"^^ . _:b482085294 . _:b482084515 . _:b482083673 "5"^^ . _:b482085289 . . _:b482086138 . _:b482083672 "5"^^ . _:b482085288 . . _:b482085096 . _:b482083675 "5"^^ . _:b482085291 . . _:b482083674 "5"^^ . _:b482086433 . _:b482085290 . _:b482083685 "5"^^ . _:b482085301 . _:b482083634 . . . _:b482083684 "5"^^ . _:b482085300 . . . _:b482084210 . . _:b482083687 "5"^^ . _:b482085303 . _:b482083686 "5"^^ . _:b482085376 . _:b482085302 . . . . _:b482085297 . _:b482083681 "5"^^ . . . . _:b482083680 "5"^^ . _:b482085296 . _:b482083433 . . . _:b482083683 "5"^^ . _:b482085299 . _:b482085462 . . _:b482083682 "5"^^ . _:b482085298 . _:b482084523 . _:b482083693 "5"^^ . _:b482085309 . . _:b482085675 . _:b482083692 "5"^^ . _:b482085308 . _:b482084266 . . . _:b482083695 "5"^^ . _:b482085311 . _:b482083694 "5"^^ . _:b482085310 . _:b482083689 "5"^^ . _:b482085305 . _:b482086182 . _:b482083688 "5"^^ . _:b482085304 . _:b482083839 . . _:b482083691 "5"^^ . _:b482085549 . _:b482085307 . _:b482085314 . _:b482083722 . _:b482083690 "5"^^ . _:b482085306 . . _:b482084743 . _:b482083701 "5"^^ . _:b482085317 . _:b482083700 "5"^^ . _:b482085316 . _:b14077296 . _:b482083703 "5"^^ . _:b482085319 . . _:b482083702 "5"^^ . _:b482085318 . _:b482084623 . _:b482086250 . _:b482083697 "5"^^ . _:b482085313 . _:b482083696 "5"^^ . _:b482085312 . . _:b482085284 . _:b482083699 "5"^^ . _:b482085315 . . _:b482085254 . _:b482083698 "5"^^ . _:b482085314 . _:b482083709 "5"^^ . _:b482085325 . . _:b482083708 "5"^^ . _:b482085324 . . _:b482086122 . . _:b482084806 . . _:b482083711 "5"^^ . _:b482085785 . _:b482085327 . . _:b482083710 "5"^^ . _:b482085326 . _:b482085049 . . "10.1038%2Fnature10738" . _:b482085859 . _:b482083705 "5"^^ . _:b482085321 . _:b482083704 "5"^^ . _:b482085344 . _:b482085320 . . _:b482083316 . _:b482084360 . . _:b482083707 "5"^^ . _:b482085323 . _:b482083803 . _:b482084301 . _:b482083706 "5"^^ . _:b482085322 . _:b482083790 . _:b482083717 "5"^^ . _:b482085333 . _:b482084221 . _:b482084958 . _:b482083716 "5"^^ . _:b482085332 . _:b482085076 . _:b482083256 . _:b482083719 "5"^^ . _:b482085335 . _:b482085318 . _:b482083718 "5"^^ . _:b482085334 . _:b482083713 "5"^^ . _:b482085329 . . . _:b482083712 "5"^^ . _:b482085328 . _:b482084336 . _:b482084542 . _:b482083715 "5"^^ . _:b482085331 . . _:b482083714 "5"^^ . _:b482085330 . _:b482083725 "5"^^ . _:b482085341 . _:b482083724 "5"^^ . _:b482085340 . . _:b482085979 . _:b482083727 "5"^^ . _:b482085343 . . _:b482083243 . . _:b482083726 "5"^^ . _:b482085342 . _:b482083721 "5"^^ . _:b482085337 . _:b482086321 . _:b482083778 . _:b482085404 . _:b482083720 "5"^^ . _:b482085336 . . . _:b482085421 . _:b482083723 "5"^^ . _:b482085339 . _:b482084736 . . _:b482083722 "5"^^ . _:b482085338 . _:b482083733 "5"^^ . _:b482085349 . _:b482084507 . _:b482083732 "5"^^ . _:b482085348 . _:b482083735 "5"^^ . _:b482085351 . . . _:b482083734 "5"^^ . _:b482085350 . _:b482084880 . . _:b482085059 . _:b482083729 "5"^^ . _:b482085345 . . _:b482083728 "5"^^ . _:b482085344 . _:b482083731 "5"^^ . _:b482085347 . . . _:b482083730 "5"^^ . _:b482085346 . _:b482086220 . . _:b482084780 . _:b482085357 . _:b482083741 "5"^^ . _:b482086124 . _:b482083740 "5"^^ . _:b482085356 . . _:b482083743 "5"^^ . _:b482085359 . _:b482083742 "5"^^ . _:b482085358 . _:b482083737 "5"^^ . _:b482085353 . _:b482083736 "5"^^ . _:b482085352 . _:b482083739 "5"^^ . _:b482085355 . _:b482085100 . _:b482083738 "5"^^ . _:b482085354 . _:b482083749 "5"^^ . _:b482085365 . _:b482085718 . _:b482083748 "5"^^ . _:b482085364 . _:b482083751 "5"^^ . _:b482085367 . _:b482083759 . _:b482083750 "5"^^ . _:b482085366 . _:b482083300 . _:b482085455 . _:b482083745 "5"^^ . _:b482085361 . _:b482083744 "5"^^ . _:b482085360 . _:b482083496 . _:b482085911 . . _:b482084663 . _:b482083747 "5"^^ . _:b482085363 . . _:b482083746 "5"^^ . _:b482085362 . _:b482086197 . _:b482083757 "5"^^ . _:b482085373 . . _:b482083756 "5"^^ . _:b482085372 . . _:b482083759 "5"^^ . _:b482085375 . . _:b482083758 "5"^^ . _:b482085374 . . _:b482085193 . _:b482083753 "5"^^ . _:b482085369 . . _:b482084997 . . _:b482083752 "5"^^ . _:b482085368 . . _:b482083755 "5"^^ . _:b482085371 . . _:b482083754 "5"^^ . _:b482085370 . . _:b482085679 . _:b482083765 "4"^^ . . _:b482083285 . _:b482084869 . _:b482083348 . _:b482083764 "4"^^ . _:b482084868 . _:b482086458 . _:b482083767 "4"^^ . _:b482084871 . . _:b482083766 "4"^^ . _:b482084870 . _:b482083761 "4"^^ . . _:b482084865 . _:b482083760 "4"^^ . _:b482084864 . _:b482083763 "4"^^ . _:b482084867 . _:b482083762 "4"^^ . _:b482083729 . _:b482084866 . _:b482084050 . _:b482083705 . _:b482083773 "4"^^ . _:b482084877 . _:b482085295 . _:b482083772 "4"^^ . _:b482084876 . _:b482084829 . _:b482083775 "4"^^ . _:b482084879 . _:b482083774 "4"^^ . _:b482084878 . _:b482084741 . . _:b482083769 "4"^^ . _:b482084873 . . . _:b482083768 "4"^^ . _:b482083614 . _:b482084872 . _:b482085242 . _:b482083771 "4"^^ . _:b482084875 . _:b482083770 "4"^^ . _:b482084874 . _:b482085960 . . _:b482083781 "4"^^ . _:b482084885 . . _:b482083780 "4"^^ . _:b482084884 . _:b482085488 . _:b482084896 . _:b482083783 "4"^^ . _:b482084887 . _:b482086361 . . _:b482084189 . _:b482083782 "4"^^ . _:b482084886 . _:b482083777 "4"^^ . _:b482084881 . _:b482083776 "4"^^ . . _:b482084880 . . _:b482083779 "4"^^ . _:b482084883 . _:b482084666 . _:b482084390 . _:b482083778 "4"^^ . . _:b482084882 . _:b482083789 "4"^^ . _:b482084893 . _:b482084787 . _:b482083788 "4"^^ . _:b482084892 . _:b482083791 "4"^^ . _:b482084895 . . _:b482083790 "4"^^ . _:b482084679 . _:b482084894 . _:b482085973 . _:b482083785 "4"^^ . _:b482084889 . _:b482083784 "4"^^ . _:b482084004 . _:b482086500 . _:b482084888 . _:b482083787 "4"^^ . _:b482084891 . _:b482083999 . _:b482083786 "4"^^ . _:b482084890 . _:b482083797 "4"^^ . _:b482084778 . _:b482084901 . _:b482083796 "4"^^ . _:b482084900 . _:b482083799 "4"^^ . _:b482085518 . _:b482084903 . _:b482083798 "4"^^ . _:b482084902 . _:b482083793 "4"^^ . _:b482084897 . _:b482083792 "4"^^ . . _:b482084896 . . _:b482083795 "4"^^ . _:b482085587 . _:b482083443 . _:b482084899 . . _:b482083227 . _:b482086348 . _:b482083794 "4"^^ . . . _:b482084898 . . _:b482083318 . _:b482083805 "4"^^ . . . _:b482083743 . _:b482084909 . _:b482083804 "4"^^ . _:b482084576 . . _:b482084908 . _:b482083862 . _:b482085036 . _:b482083807 "4"^^ . _:b482084030 . _:b482084911 . _:b482083806 "4"^^ . _:b482084910 . . _:b482083801 "4"^^ . _:b482084905 . _:b482083800 "4"^^ . _:b482086375 . _:b482084904 . _:b482083803 "4"^^ . _:b482084907 . _:b482085474 . _:b482083802 "4"^^ . _:b482084765 . _:b482084906 . _:b482083813 "4"^^ . _:b482085504 . . . _:b482084917 . _:b482086340 . _:b482083812 "4"^^ . _:b482084916 . _:b482085048 . _:b482086366 . _:b482083815 "4"^^ . . _:b482084919 . . . _:b482083814 "4"^^ . _:b482084918 . _:b482083809 "4"^^ . _:b482084913 . _:b482086067 . . _:b482083808 "4"^^ . _:b482084912 . . _:b482083811 "4"^^ . . _:b482084915 . _:b482083810 "4"^^ . _:b482084914 . _:b482085756 . _:b482084822 . _:b482083821 "4"^^ . . _:b482084925 . . _:b482083820 "4"^^ . . _:b482084924 . _:b482083823 "4"^^ . . _:b482084927 . _:b482083822 "4"^^ . _:b482084621 . . _:b482084926 . . _:b482083817 "4"^^ . _:b482083780 . _:b482084921 . _:b482083816 "4"^^ . _:b482084920 . _:b482083819 "4"^^ . _:b482084923 . _:b482086176 . _:b482083818 "4"^^ . _:b482084922 . _:b482083829 "4"^^ . _:b482084933 . _:b482083828 "4"^^ . . _:b482084932 . _:b482083831 "4"^^ . . _:b14077300 "In addition to mutations in known AML genes such as DNMT3A8, FLT39, NPM110, IDH17, IDH211, WT112, RUNX113,14, PTPRT3, PHF615, and ETV>>616<< in these 8 patients, we also discovered novel, recurring mutations in WAC, SMC3, DIS3, DDX41, and DAXX using 200 AML cases whose exomes were sequenced as part of the The Cancer Genome Atlas AML project (Table 1, Supplementary Table 4b," . _:b482084935 . . _:b482083830 "4"^^ . _:b482084934 . _:b482083825 "4"^^ . _:b482084442 . _:b482084929 . . _:b482083824 "4"^^ . _:b482083898 . _:b482084928 . _:b482083827 "4"^^ . _:b482084931 . _:b482083938 . _:b482084150 . _:b482085680 . _:b482083826 "4"^^ . _:b482084930 . _:b482083837 "4"^^ . _:b482084941 . _:b482083836 "4"^^ . . _:b482084940 . . _:b482084521 . _:b482083839 "4"^^ . _:b482084943 . _:b482083838 "4"^^ . _:b482084942 . _:b482086322 . _:b482085864 . _:b482083833 "4"^^ . . _:b482084937 . . _:b482085205 . _:b482085884 . _:b482083832 "4"^^ . _:b482084936 . . _:b482084823 . . . _:b482083835 "4"^^ . . _:b482084939 . _:b482083834 "4"^^ . _:b482084938 . _:b482084049 . _:b482083439 . _:b482084690 . _:b482084949 . . _:b482084948 . . . _:b482085385 . _:b482084951 . . _:b482085441 . . _:b482084950 . . _:b482084697 . . _:b482084945 . _:b482085871 . _:b482084944 . _:b482086226 . . _:b482084947 . _:b482085584 . . _:b482084953 . . _:b482084946 . . _:b482085339 . _:b482086270 . _:b482084957 . . _:b482084956 . . _:b482084959 . _:b482084600 . _:b482084958 . . _:b482084953 . _:b482083427 . _:b482084952 . _:b482084852 . _:b482085173 . _:b482084638 . _:b482084955 . . _:b482083601 . _:b482084954 . _:b482084965 . . _:b482084964 . _:b482084967 . . _:b482085778 . _:b482084610 . _:b482084966 . _:b482085374 . _:b482084961 . _:b482084227 . _:b482084960 . . . _:b482084963 . _:b482084962 . _:b482084660 . _:b482084264 . . _:b482084973 . _:b482085007 . _:b482084972 . . _:b482084975 . _:b482084512 . _:b482085013 . _:b482084974 . _:b482084969 . . . . _:b482084968 . . _:b482083920 . _:b482084971 . . _:b482084970 . _:b482084144 . . _:b482084981 . _:b482084980 . _:b482085498 . _:b482084983 . _:b482084472 . . _:b482085942 . _:b482084982 . _:b482084977 . . _:b482084976 . _:b482083688 . _:b482086312 . . . _:b482084979 . _:b482086244 . . _:b482084978 . _:b482083194 . . _:b482086450 . . _:b482084989 . _:b482084988 . . _:b482084991 . . _:b482085721 . . _:b482084509 . . _:b482084990 . _:b482084876 . _:b482084985 . _:b482084984 . _:b482086217 . _:b482084987 . _:b482085647 . . . _:b482084986 . _:b482084997 . . _:b482083891 . _:b482084996 . _:b482084262 . _:b482083321 . _:b482084999 . . . _:b482084998 . . _:b482084993 . _:b482083485 . _:b482084992 . . . _:b482084995 . . . _:b482084994 . _:b482086193 . _:b482085548 . _:b482085005 . _:b482085628 . _:b482085004 . _:b482085007 . . _:b482085006 . _:b482086514 . . . _:b482085001 . . . _:b482085000 . . _:b482085003 . . _:b482085002 . . _:b482085894 . _:b482085013 . _:b482084017 . _:b482085012 . _:b482083815 . _:b482085015 . _:b482085464 . _:b482085926 . _:b482085014 . . . _:b482085009 . . _:b482085008 . . . _:b482085011 . . _:b482086210 . _:b482085010 . . _:b482085021 . _:b482085368 . _:b482085020 . _:b482085023 . _:b482085022 . . _:b482085589 . _:b482085017 . _:b482085332 . _:b482085016 . . _:b482085019 . . . _:b482084183 . _:b482085018 . . _:b482086397 . _:b482084423 . _:b482085029 . . _:b482085028 . . _:b482085044 . _:b482083425 . _:b482085031 . _:b482084289 . . _:b482085030 . . . _:b482085025 . _:b482085024 . _:b482083926 . . _:b482085027 . . _:b482083434 . . _:b482085026 . _:b482086432 . _:b482085188 . _:b482085037 . . . _:b482085036 . _:b482085039 . _:b482084545 . . _:b482085038 . _:b482085033 . _:b482085032 . _:b482085035 . . . _:b482085034 . _:b482083923 . . _:b482085045 . _:b482086384 . _:b482085044 . _:b482083293 . . _:b482085047 . . _:b482085046 . _:b482085041 . _:b482085496 . _:b482085040 . _:b482086327 . . _:b482085043 . _:b482085097 . _:b482085868 . _:b482085042 . . _:b482085053 . . _:b482083192 . _:b482085052 . _:b482085055 . _:b482085002 . _:b482085054 . _:b482085049 . _:b482084413 . _:b482085048 . _:b482086336 . . _:b482085051 . . _:b482085050 . _:b482086232 . _:b482085020 . _:b482085061 . . _:b482085402 . _:b482085060 . _:b482084841 . _:b482085806 . . _:b482085600 . . . _:b482085063 . _:b482086154 . _:b482083330 . . _:b482085062 . _:b482085057 . _:b482086153 . _:b482085056 . _:b482085055 . _:b482085818 . _:b482083842 . _:b482085059 . _:b482085058 . _:b482084245 . _:b482085069 . _:b482085671 . _:b482084330 . _:b482083737 . _:b482084925 . _:b482085068 . _:b482084992 . _:b482083390 . _:b482083968 . . _:b482085071 . _:b482084047 . _:b482085039 . _:b482085070 . . _:b482085065 . _:b482084306 . . _:b482085064 . _:b482086155 . _:b482085067 . _:b482084913 . _:b482084434 . _:b482085066 . _:b482084345 . . _:b482085077 . _:b482085076 . _:b482085079 . _:b482085078 . . _:b482085073 . _:b482085072 . _:b482086400 . . . _:b482085075 . . _:b482085074 . _:b482086082 . _:b482085085 . _:b482083414 . _:b482084024 . _:b482085084 . _:b482085087 . _:b482084253 . _:b482085086 . _:b482085290 . . _:b482085081 . . _:b482085080 . _:b482085083 . _:b482085082 . _:b482084646 . _:b482085093 . _:b482085754 . _:b482085092 . _:b482084268 . _:b482085095 . _:b482085489 . _:b482085094 . _:b482084363 . _:b482085089 . . _:b482085088 . _:b482083845 . _:b482085091 . _:b482085090 . _:b482083724 . _:b482084127 . . _:b482085101 . _:b482084387 . _:b482084942 . _:b482085100 . _:b482085103 . _:b482083270 . _:b482085102 . _:b482085097 . . _:b482085096 . . _:b482083979 . _:b482085099 . _:b482085098 . . . _:b482085109 . . . _:b482085108 . _:b482083311 . _:b482085111 . _:b482084195 . _:b482084752 . . _:b482085110 . _:b482083675 . _:b482085105 . . _:b482085104 . _:b482083191 . _:b482085107 . _:b482085436 . _:b482085106 . . _:b482085117 . . _:b482085116 . _:b482084267 . . . _:b482085119 . _:b482085814 . _:b482085118 . . _:b482085113 . . _:b482085112 . _:b482085115 . _:b482086238 . _:b482085114 . _:b482084157 . . . . . . _:b482086559 . . . . . _:b482085741 . _:b482085704 . _:b482085129 . . . . . . _:b482085236 . . _:b482083268 . _:b482086201 . _:b482086331 . _:b482085303 . . . _:b482083812 . _:b482085082 . _:b482084441 . . _:b482086284 . . _:b482084479 . . _:b482085180 . _:b482084063 . _:b482084946 . _:b482084845 . _:b482085755 . . . _:b482086076 . _:b482083589 . . . . . _:b482084124 . _:b482085971 . _:b482085870 . _:b482086265 . . _:b482086490 . . . _:b482084696 . . _:b482085124 . _:b482085896 . _:b14077309 "evolution; clonal evolution can also occur after allogeneic transplantation (e.g. loss of mismatched HLA alleles via a uniparental disomy mechanism), demonstrating that the type of therapy itself can affect clonal evolution at relapse>>26<<,27. Taken together, these data demonstrate that AML cells routinely acquire a small number of additional mutations at relapse, and suggest that some of these mutations may contribute to clonal selection and chemotherapy resistance." . _:b482084130 . _:b482084801 . . _:b482086430 . _:b482086267 . _:b482085355 . _:b482084372 . . . _:b482086059 . _:b482085687 . _:b482083732 . _:b482086072 . . . . . _:b482085382 . . . _:b482084120 . . _:b482084734 . _:b482084381 . . . _:b482083657 . . _:b482084895 . _:b482086504 . . . _:b482084998 . . _:b482086110 . _:b482083899 . _:b482086242 . _:b482083925 . _:b482085803 . _:b482084263 . _:b482085706 . _:b482083840 . _:b482083302 . . . . _:b482085281 . . _:b482085773 . _:b482084974 . _:b14077284 _:b14077300 . _:b14077284 _:b14077301 . _:b14077284 _:b14077302 . . _:b14077284 _:b14077296 . _:b14077284 _:b14077297 . _:b14077284 _:b14077298 . _:b482084279 . . . _:b14077284 _:b14077299 . . . . _:b482085011 . _:b482085179 . _:b14077284 _:b14077285 . _:b14077284 _:b14077286 . _:b14077284 _:b14077287 . . _:b14077284 _:b14077292 . _:b14077284 _:b14077293 . _:b14077284 _:b14077294 . _:b14077284 _:b14077295 . _:b14077297 . . _:b482085245 . _:b14077284 _:b14077288 . _:b482083253 . _:b14077284 _:b14077289 . _:b14077284 _:b14077290 . _:b482085357 . _:b482083680 . _:b14077284 _:b14077291 . _:b482083537 . _:b14077299 . _:b482084098 . _:b482085824 . _:b482084446 . . . . _:b482085929 . _:b14077303 _:b14077304 . _:b14077303 _:b14077305 . . _:b14077303 _:b14077306 . . _:b482085477 . _:b482084297 . _:b14077303 _:b14077307 . _:b14077303 _:b14077308 . _:b14077303 _:b14077309 . _:b14077303 _:b14077310 . . . . . _:b482086065 . . _:b482085698 . _:b482085434 . _:b482086465 . _:b482086129 . _:b482085480 . _:b482086140 . _:b482084658 . _:b482085551 . . . . . _:b482086506 . _:b482086428 . . . _:b482086027 . . _:b482083665 . . _:b482086057 . . . _:b14077311 _:b14077312 . _:b482086380 . . _:b482085908 . . . _:b482085400 . . _:b482083289 . _:b482085644 . . . _:b482084015 . _:b482085336 . _:b482084758 . _:b482085313 . . _:b482083411 . . _:b482086479 . _:b482084921 . _:b482085145 . . . _:b482086379 . . . . _:b482083202 . _:b482084155 . _:b482083337 . _:b14077290 "In addition to mutations in known AML genes such as DNMT3A>>8<<, FLT39, NPM110, IDH17, IDH211, WT112, RUNX113,14, PTPRT3, PHF615, and ETV616 in these 8 patients, we also discovered novel, recurring mutations in WAC, SMC3, DIS3, DDX41, and DAXX using 200 AML cases whose exomes were sequenced as part of" . _:b482084334 . . . _:b482086117 . . _:b14077297 "In addition to mutations in known AML genes such as DNMT3A8, FLT39, NPM110, IDH17, IDH211, WT112, RUNX113,>>14<<, PTPRT3, PHF615, and ETV616 in these 8 patients, we also discovered novel, recurring mutations in WAC, SMC3, DIS3, DDX41, and DAXX using 200 AML cases whose exomes were sequenced as part of the The Cancer Genome Atlas AML project (Table" . . . . . . . _:b482083694 . . . . . . _:b482086245 . . . . _:b482085487 . . . . . _:b482086130 . . . . . _:b482086058 . _:b482085037 . . _:b482084037 . . _:b482084163 . _:b482083298 . _:b482083477 . . . _:b482083942 . _:b482083428 . . _:b482083183 . . . . . _:b482085169 . _:b482084607 . _:b482083197 "35"^^ . . _:b482084461 . _:b482083196 "36"^^ . . _:b482083199 "34"^^ . . _:b482083198 "34"^^ . . _:b482083194 "38"^^ . _:b482083626 . _:b482083192 "39"^^ . _:b482083195 "36"^^ . _:b482086472 . _:b482083193 "38"^^ . _:b482083185 "50"^^ . . . _:b482083190 "39"^^ . . _:b482083184 "51"^^ . . _:b482083191 "39"^^ . _:b482084774 . _:b482083186 "49"^^ . _:b482085885 . _:b482083187 "48"^^ . _:b482083274 . _:b482083189 "40"^^ . _:b482083188 "45"^^ . . . _:b482084729 . . . . _:b482086163 . . _:b482085384 . _:b482083182 "56"^^ . . _:b482083183 "51"^^ . _:b482084392 . _:b482085668 . _:b482084878 . _:b482086376 . _:b482083179 "88"^^ . _:b482085815 . _:b482083180 "81"^^ . _:b482083181 "80"^^ . _:b482085309 . . _:b482083328 . _:b482084398 . . _:b482083203 "29"^^ . _:b482083470 . . . _:b482084772 . _:b482083202 "29"^^ . _:b482083207 "28"^^ . _:b482084350 . _:b482083206 "28"^^ . _:b482086241 . _:b482084931 . . _:b482083205 "28"^^ . _:b482083204 "28"^^ . . _:b482083210 "26"^^ . . _:b482083211 "25"^^ . _:b482083209 "26"^^ . . _:b482083208 "26"^^ . . _:b482084604 . _:b482086492 . . _:b482083214 "24"^^ . . _:b482083215 "24"^^ . . . _:b482083212 "25"^^ . _:b482085797 . _:b482083213 "25"^^ . _:b482083218 "23"^^ . _:b482083362 . _:b482083219 "23"^^ . _:b482084256 . . . . _:b482085601 . . _:b482083216 "24"^^ . _:b482083217 "24"^^ . _:b482083222 "22"^^ . . _:b482084580 . _:b482083220 "23"^^ . _:b482083223 "21"^^ . _:b482083221 "23"^^ . _:b482086292 . _:b482083225 "21"^^ . . . _:b482083224 "21"^^ . _:b482084865 . . _:b482083227 "20"^^ . . _:b482083226 "20"^^ . . _:b482083200 "32"^^ . _:b482083229 "20"^^ . _:b482084211 . _:b482084536 . _:b482083201 "31"^^ . _:b482083228 "20"^^ . _:b482083231 "19"^^ . _:b482083230 "19"^^ . . _:b482086461 . _:b482083233 "18"^^ . . . . _:b482083232 "19"^^ . . _:b482083235 "18"^^ . _:b482083234 "18"^^ . _:b482083237 "18"^^ . . _:b482083236 "18"^^ . . _:b482083239 "18"^^ . _:b482086160 . _:b482084647 . _:b482083238 "18"^^ . . . _:b482085688 . . _:b482083569 . _:b482085616 . _:b482083240 "17"^^ . . _:b482086144 . _:b482084606 . _:b482085751 . _:b482083241 "17"^^ . _:b482083242 "16"^^ . _:b482083243 "16"^^ . _:b482083244 "16"^^ . _:b482084877 . _:b482083245 "16"^^ . _:b482083981 . _:b482083246 "16"^^ . _:b482083247 "16"^^ . _:b482083458 . _:b482083248 "15"^^ . _:b482083249 "15"^^ . _:b482083250 "15"^^ . _:b482086010 . _:b482083251 "15"^^ . _:b482086539 . _:b482086033 . . _:b482083252 "15"^^ . . _:b482083253 "15"^^ . _:b482085608 . . . _:b482083254 "15"^^ . _:b482083255 "14"^^ . _:b482083853 . . . _:b482083256 "14"^^ . _:b482085190 . . . _:b482083257 "14"^^ . _:b482083258 "14"^^ . _:b482083393 . . _:b482083259 "14"^^ . _:b482083230 . _:b482083260 "14"^^ . _:b482083261 "14"^^ . . _:b482085103 . _:b482083262 "14"^^ . _:b482085825 . . . . _:b482083263 "14"^^ . . _:b482083767 . _:b482083264 "14"^^ . . _:b482083271 "13"^^ . _:b482083265 "14"^^ . _:b482084014 . _:b482083270 "13"^^ . _:b482084439 . _:b482083269 "13"^^ . _:b482084204 . _:b482086247 . _:b482083268 "13"^^ . _:b482085635 . _:b482083267 "13"^^ . _:b482086325 . _:b482085965 . _:b482083266 "13"^^ . . _:b482083896 . . _:b482084986 . _:b482085730 . . _:b482083279 "13"^^ . . . _:b482083278 "13"^^ . _:b482083917 . _:b482083277 "13"^^ . . . _:b482083276 "13"^^ . . _:b482083275 "13"^^ . _:b482083274 "13"^^ . _:b482085383 . _:b482083273 "13"^^ . _:b482083272 "13"^^ . _:b482083287 "12"^^ . _:b482083286 "12"^^ . . _:b482083285 "12"^^ . _:b482086038 . _:b482083284 "12"^^ . . _:b482083283 "12"^^ . . _:b482083490 . _:b482083282 "12"^^ . _:b482084718 . _:b482083281 "13"^^ . _:b482083280 "13"^^ . _:b482083295 "12"^^ . _:b482085939 . _:b482086194 . . . _:b482083294 "12"^^ . _:b482083293 "12"^^ . _:b482084649 . _:b482083493 . _:b482083292 "12"^^ . _:b482083291 "12"^^ . . _:b482083829 . _:b482083647 . _:b482083426 . _:b482083290 "12"^^ . _:b482083289 "12"^^ . _:b482083288 "12"^^ . . _:b482085323 . _:b482083303 "11"^^ . _:b482085110 . _:b482084816 . . _:b482083461 . . _:b482083302 "11"^^ . _:b482084612 . _:b482083301 "11"^^ . . _:b482085269 . . . _:b482083300 "11"^^ . _:b482084242 . _:b482083299 "12"^^ . _:b482085200 . . _:b482083298 "12"^^ . . . _:b482083297 "12"^^ . _:b482084029 . _:b482083296 "12"^^ . . _:b482083311 "11"^^ . _:b482085776 . _:b482083310 "11"^^ . _:b482083462 . _:b482083309 "11"^^ . _:b482085697 . . . _:b482083308 "11"^^ . _:b482083307 "11"^^ . . _:b482085327 . _:b482083306 "11"^^ . _:b482086498 . _:b482085104 . _:b482083305 "11"^^ . _:b482084636 . _:b482084655 . _:b482083304 "11"^^ . _:b482083319 "10"^^ . . _:b482083766 . . _:b482083318 "10"^^ . _:b482085347 . _:b482083317 "10"^^ . . _:b482083316 "11"^^ . _:b482085469 . _:b482083315 "11"^^ . _:b482086297 . _:b482083404 . _:b482083314 "11"^^ . _:b482085458 . _:b482083313 "11"^^ . _:b482084305 . . _:b482083312 "11"^^ . _:b482083327 "10"^^ . _:b482085274 . . . _:b482083326 "10"^^ . _:b482086515 . _:b482083325 "10"^^ . _:b482083967 . _:b482083324 "10"^^ . _:b482083381 . . . . _:b482083323 "10"^^ . . _:b482083322 "10"^^ . _:b14077289 . _:b482083321 "10"^^ . _:b482083824 . _:b482083320 "10"^^ . _:b482084578 . _:b482086405 "2"^^ . _:b482085650 . _:b482083660 . _:b14077290 . . _:b482086404 "2"^^ . _:b482086100 . _:b482084095 . _:b482086407 "2"^^ . _:b482086406 "2"^^ . _:b482084907 . _:b482084335 . . _:b482086401 "2"^^ . _:b482086142 . _:b482085287 . . _:b482083651 . _:b482086400 "2"^^ . _:b482083623 . _:b482084370 . _:b482086403 "2"^^ . . _:b482085707 . . _:b482086402 "2"^^ . _:b482086413 "2"^^ . _:b482086412 "2"^^ . . _:b482083333 . _:b482086415 "2"^^ . _:b482085677 . . _:b482086414 "2"^^ . _:b482086409 "2"^^ . . _:b482086408 "2"^^ . _:b482086408 . . _:b482086411 "2"^^ . . . _:b482086410 "2"^^ . _:b482086421 "2"^^ . . _:b482086420 "2"^^ . _:b482085966 . _:b482084785 . _:b482084298 . _:b482086423 "2"^^ . _:b482085907 . _:b482086422 "2"^^ . _:b482083798 . _:b482086417 "2"^^ . _:b482083627 . _:b482086416 "2"^^ . _:b482085058 . _:b482086419 "2"^^ . . _:b482086418 "2"^^ . . _:b482084839 . _:b482086429 "2"^^ . . _:b482084167 . _:b482086428 "2"^^ . _:b482084687 . . . _:b482086431 "2"^^ . _:b482084934 . _:b482085317 . . _:b482085760 . _:b482086430 "2"^^ . _:b482083501 . _:b482086425 "2"^^ . _:b482084872 . _:b482086424 "2"^^ . _:b482086181 . _:b482086427 "2"^^ . _:b482084121 . _:b482085775 . _:b482086426 "2"^^ . . _:b482086437 "2"^^ . _:b482083901 . _:b482086436 "2"^^ . . _:b482086439 "2"^^ . _:b482086438 "2"^^ . _:b482084766 . _:b482086412 . . _:b482086433 "2"^^ . _:b482083855 . . . _:b482086432 "2"^^ . . _:b482086435 "2"^^ . _:b482084575 . _:b482086434 "2"^^ . _:b482083883 . _:b482084972 . _:b482086445 "2"^^ . _:b482084332 . _:b482086444 "2"^^ . . . _:b482086447 "2"^^ . _:b482086446 "2"^^ . _:b482084111 . . _:b482086441 "2"^^ . _:b482085577 . _:b482086440 "2"^^ . _:b482086443 "2"^^ . _:b482086134 . . _:b482086442 "2"^^ . . _:b482086453 "2"^^ . . _:b482086452 "2"^^ . . _:b482086455 "2"^^ . _:b482083740 . _:b482086454 "2"^^ . . _:b482086449 "2"^^ . _:b482083502 . _:b482085275 . . _:b482086448 "2"^^ . _:b482086418 . _:b14077305 "This study extends the findings of Mullighan et al.>>19<<, Anderson et al.20, and Notta et al." . _:b482083972 . _:b482086451 "2"^^ . . . _:b482086450 "2"^^ . _:b482086461 "2"^^ . _:b482083524 . . _:b482086460 "2"^^ . . _:b482086463 "2"^^ . . _:b482086462 "2"^^ . . . _:b482086457 "2"^^ . _:b482086456 "2"^^ . . _:b482086459 "2"^^ . _:b482085277 . _:b482086392 . _:b482086458 "2"^^ . _:b482085843 . _:b482086469 "2"^^ . _:b482083962 . _:b482084640 . _:b482084904 . _:b482086468 "2"^^ . . _:b482084196 . _:b482086471 "2"^^ . _:b482084094 . _:b482086470 "2"^^ . _:b482084952 . . _:b482086465 "2"^^ . _:b482086026 . _:b482086464 "2"^^ . . _:b482086467 "2"^^ . _:b482086466 "2"^^ . _:b482086560 . . _:b482083667 . _:b482086477 "2"^^ . . . _:b482086476 "2"^^ . . _:b482085484 . _:b482084698 . _:b482086479 "2"^^ . . _:b482086478 "2"^^ . . _:b482084899 . . _:b482086473 "2"^^ . . _:b482085398 . _:b482086472 "2"^^ . . _:b482083847 . _:b482086475 "2"^^ . _:b482086474 "2"^^ . _:b482084122 . . . _:b482086485 "2"^^ . . _:b482086484 "2"^^ . _:b482084296 . _:b482086487 "2"^^ . _:b482083277 . _:b482084767 . _:b482085805 . _:b482086486 "2"^^ . _:b482085340 . _:b482086481 "2"^^ . _:b482084776 . _:b482086480 "2"^^ . _:b482086483 "2"^^ . _:b482085794 . . _:b482086482 "2"^^ . _:b482086493 "2"^^ . . . . _:b482086492 "2"^^ . . _:b482086495 "2"^^ . _:b482086494 "2"^^ . _:b482086489 "2"^^ . . _:b482086488 "2"^^ . _:b482083859 . _:b482086491 "2"^^ . . _:b482085299 . _:b482086490 "2"^^ . . _:b482084235 . _:b482086501 "2"^^ . . _:b482086500 "2"^^ . _:b482084092 . . _:b482086503 "2"^^ . _:b482084751 . _:b482086502 "2"^^ . _:b482084364 . _:b482085021 . _:b482086497 "2"^^ . _:b482086496 "2"^^ . _:b482086499 "2"^^ . . _:b14077304 "We first described the use of deep sequencing to precisely define the variant allele frequencies of the mutations in the AML genome of case >>9331243<<, and here have refined and extended this technique to examine clonal evolution at relapse." . _:b482085283 . _:b482086498 "2"^^ . . _:b482085595 . _:b482084789 . . _:b482086509 "2"^^ . _:b482085999 . _:b482083408 . _:b482086508 "2"^^ . . _:b482085311 . _:b482086511 "2"^^ . . _:b482086281 . _:b482086510 "2"^^ . . _:b482085570 . _:b482086505 "2"^^ . . _:b482086504 "2"^^ . _:b482083518 . . _:b482086507 "2"^^ . _:b482086506 "2"^^ . _:b482086517 "2"^^ . _:b482086516 "2"^^ . . _:b482086519 "2"^^ . _:b482085483 . _:b482086146 . _:b482086518 "2"^^ . _:b482086513 "2"^^ . . _:b482086512 "2"^^ . _:b482086515 "2"^^ . _:b482086335 . _:b482086514 "2"^^ . _:b482086525 "2"^^ . _:b482086524 "2"^^ . _:b482085962 . . _:b482086527 "2"^^ . _:b482086273 . _:b482086526 "2"^^ . _:b482083545 . _:b482086521 "2"^^ . _:b482086520 "2"^^ . _:b482084344 . _:b482086523 "2"^^ . _:b482086106 . _:b482086522 "2"^^ . _:b482086533 "2"^^ . _:b482086532 "2"^^ . _:b482083543 . _:b482086535 "2"^^ . . _:b482086534 "2"^^ . . _:b482086529 "2"^^ . . _:b482086528 "2"^^ . _:b482083918 . _:b482086531 "2"^^ . _:b482086530 "2"^^ . _:b482086541 "2"^^ . _:b482086540 "2"^^ . . _:b482086543 "2"^^ . _:b482083384 . . _:b482086542 "2"^^ . . . . _:b482086537 "2"^^ . _:b482085369 . . _:b482086536 "2"^^ . . _:b482086539 "2"^^ . _:b482086459 . _:b482086489 . _:b482086538 "2"^^ . _:b482085016 . _:b482083703 . _:b482086549 "2"^^ . _:b482086548 "2"^^ . _:b482086012 . _:b482086551 "2"^^ . _:b482086550 "2"^^ . . _:b482086545 "2"^^ . _:b482085682 . _:b482086544 "2"^^ . . _:b482086022 . _:b482086547 "2"^^ . _:b482083505 . _:b482084630 . _:b482086073 . _:b482086546 "2"^^ . . _:b482086557 "2"^^ . _:b482086556 "2"^^ . . _:b482086559 "2"^^ . . . _:b482086558 "2"^^ . _:b482086086 . _:b482086553 "2"^^ . _:b482086552 "2"^^ . _:b482086555 "2"^^ . _:b482086554 "2"^^ . _:b482084614 . _:b482084097 . _:b482083591 . _:b482083196 . _:b482083991 . . _:b482086561 "2"^^ . _:b14077308 . _:b482086560 "2"^^ . _:b482085046 . . _:b482084726 . _:b482086381 . . _:b482086128 . _:b482085467 . . _:b482085765 . _:b482084281 . . _:b482083473 . . _:b482086468 . _:b482085213 . _:b14077309 . _:b482083556 . . _:b482085352 . _:b482084232 . . _:b482086222 . _:b482084601 . _:b482085043 . . . . _:b482085450 . . . . _:b482086212 . . . _:b482085758 . _:b482083702 . _:b482086482 . _:b482084403 . . . . _:b482086257 . _:b482085130 . . _:b482083377 . . . . _:b482083725 . _:b482085047 . _:b482083615 . _:b482086442 . . . . . . _:b482084704 . . . . . . _:b482083278 . _:b482084965 . . _:b482085022 . _:b482085459 . _:b482084365 . . . _:b482083774 . . . . . _:b482084274 . _:b482083849 . . _:b482083530 . . _:b482083775 . _:b482085435 . . . . . _:b482084080 . _:b482084572 . _:b482083453 . _:b482084386 . . _:b482083297 . . . . _:b482084926 . . _:b482084637 . _:b482085714 . _:b482085009 . . . . . _:b482083889 . _:b482086190 . . . _:b482085726 . . . _:b482086427 . _:b482085609 . . _:b482085325 . _:b482085121 . _:b482086177 . _:b482085134 . _:b482084208 . . . . . . _:b482083554 . . _:b482085693 . _:b482085841 . . . _:b482085187 . _:b482085752 . _:b482084749 . _:b482086307 . . _:b482085238 . _:b482086378 . . . . . _:b482083717 . . . . _:b482086467 . _:b482085354 . _:b482084779 . _:b482086200 . _:b482084613 . . . _:b482086083 . . _:b482083998 . _:b482084288 . . _:b482084008 . _:b482085185 . _:b482084156 . _:b482086301 . _:b482086478 . _:b482084651 . _:b482085204 . . _:b482084408 . _:b482083250 . . . . _:b482086248 . . _:b482085919 . . _:b482084420 . _:b482084964 . _:b14077310 "evolution; clonal evolution can also occur after allogeneic transplantation (e.g. loss of mismatched HLA alleles via a uniparental disomy mechanism), demonstrating that the type of therapy itself can affect clonal evolution at relapse26,>>27<<. Taken together, these data demonstrate that AML cells routinely acquire a small number of additional mutations at relapse, and suggest that some of these mutations may contribute to clonal selection and chemotherapy resistance." . . . _:b482085296 . . . _:b482083396 . _:b482085302 . _:b482084493 . . _:b482083464 . _:b482085509 . . _:b482084171 . . _:b482086150 . _:b482084244 . . . . _:b482084980 . . . _:b482083973 . . _:b482083637 . . _:b482086169 . . _:b482083730 . . _:b482086230 . . . . . . . _:b482084609 . . _:b482083573 . _:b482085738 . _:b482085821 . _:b482084987 . _:b482083769 . _:b14077305 . . _:b482084358 . _:b482086209 . _:b482084735 . . _:b482083580 . _:b482086049 . . . _:b482083389 . . . _:b482084495 . . . . . _:b482084856 . . . . . . . _:b482086024 . . _:b482083357 . . . _:b482084126 . _:b482085105 . _:b482083447 . . _:b482085084 . _:b482084486 . _:b482085784 . _:b482084908 . . . . _:b482084243 . . . . . _:b482083984 . . . . _:b482086346 . . _:b482084494 . . . _:b482083791 . _:b482084073 . _:b482085734 . . _:b482084889 . . _:b482084125 . . _:b482085094 . _:b482083872 . . _:b482084673 . _:b482083248 . _:b482085620 . . _:b482086421 . _:b482084990 . . . _:b14077307 . . . _:b482085673 . . _:b482086373 . _:b482086191 . _:b482083770 . _:b482086149 . _:b482084035 . _:b482084510 . . _:b482085106 . _:b482084361 . _:b482084819 . _:b482083708 . _:b482084828 . . _:b482083741 . . _:b14077292 . _:b482085630 . . _:b482085091 . _:b482084341 . . _:b482085478 . . . . _:b482085742 . _:b482083329 . . _:b482083597 . _:b482083415 . _:b482083608 . _:b482084624 . _:b482085887 . . _:b482084937 . . _:b482083683 . _:b482086328 . _:b482085640 . _:b482086404 . _:b482085684 . _:b482085876 . . . . _:b482085008 . . . _:b482084608 . . . . . _:b482085834 . _:b482086371 . _:b482085933 . . . _:b482083313 . _:b482085164 . . . _:b482084497 . _:b482085485 . . . _:b482084873 . . . _:b482084238 . _:b482084641 . . _:b482084096 . _:b482085592 . _:b482085494 . . _:b482084411 . _:b482083881 . _:b482086279 . . _:b482083799 . . . _:b482084968 . . _:b482085670 . _:b482083909 . _:b482085413 . _:b482086052 . _:b482083266 . _:b482086108 . . . . . . . _:b482083523 . . . . _:b482084783 . _:b482085211 . . . . _:b482086112 . _:b482084391 . . _:b482083257 . . . . . _:b482085544 . _:b482085921 . _:b482084378 . _:b482083924 . _:b482083575 . _:b482083283 . . . _:b482083593 . . . _:b482085995 . _:b482083700 . . _:b482085329 . . . _:b482086298 . . _:b482084915 . . . _:b482085893 "2"^^ . _:b482085892 "2"^^ . . _:b482085895 "2"^^ . . . _:b482085894 "2"^^ . _:b482086137 . _:b482084501 . _:b482083875 . _:b482085889 "2"^^ . . . _:b482085888 "2"^^ . . _:b482085891 "2"^^ . _:b482085890 "2"^^ . _:b482086443 . . . _:b482085901 "2"^^ . _:b482085900 "2"^^ . _:b482084771 . . _:b482085903 "2"^^ . _:b482084960 . _:b482085902 "2"^^ . _:b482085897 "2"^^ . . _:b482085896 "2"^^ . . _:b482086557 . _:b482085899 "2"^^ . _:b482085112 . _:b482085898 "2"^^ . _:b482085909 "2"^^ . _:b482085908 "2"^^ . _:b482085911 "2"^^ . _:b14077299 "In addition to mutations in known AML genes such as DNMT3A8, FLT39, NPM110, IDH17, IDH211, WT112, RUNX113,14, PTPRT3, PHF>>615<<, and ETV616 in these 8 patients, we also discovered novel, recurring mutations in WAC, SMC3, DIS3, DDX41, and DAXX using 200 AML cases whose exomes were sequenced as part of the The Cancer Genome Atlas AML project (Table 1, Supplementary" . _:b482085910 "2"^^ . . . _:b482083232 . _:b482083874 . _:b482085905 "2"^^ . . _:b482085904 "2"^^ . _:b482085832 . _:b482085907 "2"^^ . _:b482085906 "2"^^ . . _:b482085917 "2"^^ . _:b482085649 . _:b482085916 "2"^^ . _:b482085457 . _:b482083190 . _:b482085919 "2"^^ . _:b482084668 . _:b482085918 "2"^^ . . _:b482085913 "2"^^ . _:b482085681 . . _:b482085912 "2"^^ . _:b482085017 . _:b482085183 . _:b482085915 "2"^^ . _:b482084844 . _:b482085914 "2"^^ . . _:b482085925 "2"^^ . _:b482085924 "2"^^ . . _:b482085701 . _:b482085927 "2"^^ . . _:b482085926 "2"^^ . . . _:b482083928 . _:b482085921 "2"^^ . _:b482085399 . . _:b482085920 "2"^^ . . _:b482085923 "2"^^ . . _:b482084862 . _:b482085922 "2"^^ . _:b482085219 . _:b482083941 . _:b482085933 "2"^^ . . . . . _:b482085932 "2"^^ . . . _:b482085935 "2"^^ . _:b482085934 "2"^^ . _:b482086332 . _:b482085212 . _:b482085929 "2"^^ . . _:b482085928 "2"^^ . . . . _:b482083851 . . . _:b482085931 "2"^^ . . . . _:b482085930 "2"^^ . _:b482085941 "2"^^ . _:b482085940 "2"^^ . _:b482086551 . . _:b482085976 . _:b482085943 "2"^^ . _:b482086476 . _:b482085942 "2"^^ . _:b482085937 "2"^^ . . _:b482085745 . _:b482085936 "2"^^ . _:b482086009 . _:b482085939 "2"^^ . . . . _:b482085938 "2"^^ . . _:b482085949 "2"^^ . _:b482083327 . _:b482085948 "2"^^ . . . _:b482085951 "2"^^ . _:b482085950 "2"^^ . _:b482085945 "2"^^ . _:b482085944 "2"^^ . _:b482085947 "2"^^ . _:b482085538 . _:b482085946 "2"^^ . . _:b14077289 "In addition to the ten somatic nonsynonymous mutations originally reported for the primary tumor sample3, we identified one deletion that was not detected in the original analysis (DNMT3A L723fs>>8<<) and three missense mutations previously misclassified as germline events (SMC3 G662C, PDXDC1 E421K, and TTN E14263K) (Fig." . . _:b482085957 "2"^^ . _:b482085956 "2"^^ . _:b482084003 . . _:b482085959 "2"^^ . . _:b482085958 "2"^^ . _:b482085953 "2"^^ . _:b482085952 "2"^^ . . . _:b482085955 "2"^^ . _:b482085954 "2"^^ . . _:b482086486 . . _:b482085965 "2"^^ . _:b482084308 . _:b482085964 "2"^^ . _:b482083752 . . . _:b482085967 "2"^^ . _:b482084022 . _:b482084978 . _:b482085966 "2"^^ . _:b482085961 "2"^^ . _:b482085405 . _:b482085960 "2"^^ . _:b482084682 . _:b482084200 . _:b482085963 "2"^^ . _:b482086062 . _:b482085962 "2"^^ . _:b482085973 "2"^^ . _:b482083291 . _:b482085804 . _:b482085972 "2"^^ . _:b482085842 . . . _:b482085975 "2"^^ . . _:b482085974 "2"^^ . . _:b482085969 "2"^^ . _:b482085968 "2"^^ . _:b482083358 . _:b482085971 "2"^^ . . _:b482085970 "2"^^ . _:b482084116 . _:b482085981 "2"^^ . _:b482084859 . _:b482083679 . _:b482085980 "2"^^ . _:b482085288 . _:b482085983 "2"^^ . . . . _:b482085982 "2"^^ . _:b482085977 "2"^^ . _:b482085976 "2"^^ . . _:b482085979 "2"^^ . . _:b482085978 "2"^^ . _:b482085989 "2"^^ . . _:b482085988 "2"^^ . . _:b482085991 "2"^^ . _:b482085990 "2"^^ . _:b482083258 . . _:b482085985 "2"^^ . _:b482084797 . _:b482085984 "2"^^ . . _:b482085987 "2"^^ . . _:b482085986 "2"^^ . _:b482086414 . _:b482085997 "2"^^ . _:b482084209 . _:b482085996 "2"^^ . _:b482084261 . . _:b482084938 . _:b482085999 "2"^^ . _:b482085998 "2"^^ . . . _:b482085993 "2"^^ . _:b482085992 "2"^^ . _:b482083577 . _:b482085995 "2"^^ . . . _:b482085994 "2"^^ . . . . _:b482086005 "2"^^ . _:b482086004 "2"^^ . _:b482083916 . . _:b482086007 "2"^^ . _:b482086053 . _:b482084982 . _:b482086006 "2"^^ . . _:b482086001 "2"^^ . _:b482086000 "2"^^ . _:b482084357 . _:b482083772 . _:b482086003 "2"^^ . _:b482086002 "2"^^ . _:b482086013 "2"^^ . . _:b482084855 . _:b482086012 "2"^^ . . _:b482086015 "2"^^ . . _:b482086014 "2"^^ . _:b482086009 "2"^^ . . _:b482085951 . . _:b482086008 "2"^^ . _:b482086454 . . _:b482086011 "2"^^ . . _:b482086010 "2"^^ . _:b482086021 "2"^^ . . _:b482086020 "2"^^ . _:b482085970 . _:b482086023 "2"^^ . . _:b482086022 "2"^^ . . . _:b482086017 "2"^^ . . _:b482086016 "2"^^ . . _:b482085492 . _:b482086019 "2"^^ . _:b482085466 . _:b482086018 "2"^^ . . _:b482086029 "2"^^ . _:b482084502 . _:b482086028 "2"^^ . _:b482085392 . _:b482086208 . _:b482086031 "2"^^ . . _:b482085940 . _:b482086030 "2"^^ . _:b482086025 "2"^^ . _:b482084753 . _:b482086024 "2"^^ . _:b482086170 . _:b482084068 . _:b482086027 "2"^^ . . _:b482086026 "2"^^ . _:b482085500 . _:b482086037 "2"^^ . . _:b482085029 . _:b482086036 "2"^^ . . _:b482086039 "2"^^ . _:b482086038 "2"^^ . . _:b482086033 "2"^^ . . . _:b482086032 "2"^^ . _:b482085473 . _:b482086035 "2"^^ . _:b482083261 . . _:b482086034 "2"^^ . _:b482086045 "2"^^ . . _:b482086044 "2"^^ . . _:b482083773 . _:b482084043 . . _:b482086047 "2"^^ . _:b482086046 "2"^^ . . _:b482086041 "2"^^ . _:b482086040 "2"^^ . _:b482085042 . _:b482085301 . _:b482086043 "2"^^ . _:b482083224 . . _:b482086042 "2"^^ . _:b482085437 . _:b482086053 "2"^^ . _:b482085689 . . _:b482085531 . _:b482086052 "2"^^ . . _:b482086055 "2"^^ . . _:b482086054 "2"^^ . . _:b482086049 "2"^^ . _:b482086048 "2"^^ . . _:b482086051 "2"^^ . _:b482086050 "2"^^ . . . _:b482086061 "2"^^ . . _:b482086060 "2"^^ . _:b482086063 "2"^^ . . _:b482083359 . _:b482084628 . _:b482086062 "2"^^ . . _:b482086057 "2"^^ . _:b482086056 "2"^^ . . _:b482086059 "2"^^ . _:b482086058 "2"^^ . . _:b482086069 "2"^^ . _:b482086068 "2"^^ . _:b482086071 "2"^^ . _:b482086070 "2"^^ . _:b482086065 "2"^^ . _:b482083789 . _:b482086064 "2"^^ . . _:b482086067 "2"^^ . _:b482084589 . _:b482086066 "2"^^ . . _:b482086077 "2"^^ . _:b482083286 . _:b482086076 "2"^^ . _:b482086079 "2"^^ . _:b482083295 . _:b482083638 . _:b482086305 . _:b482086078 "2"^^ . _:b482086073 "2"^^ . _:b482085394 . _:b482086519 . _:b482086072 "2"^^ . . _:b482086216 . _:b482085038 . _:b482086075 "2"^^ . 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. _:b482084315 . _:b482086136 "2"^^ . . . . _:b482086139 "2"^^ . _:b482086138 "2"^^ . . _:b482085638 . _:b482086149 "2"^^ . _:b482086148 "2"^^ . _:b482086151 "2"^^ . _:b482086150 "2"^^ . . _:b482086145 "2"^^ . _:b482085074 . _:b482086144 "2"^^ . _:b482086448 . _:b482086147 "2"^^ . _:b482086146 "2"^^ . . . _:b482086157 "2"^^ . _:b482083822 . _:b482086537 . . . _:b482086156 "2"^^ . . _:b482086159 "2"^^ . _:b482084635 . _:b482086158 "2"^^ . . _:b482086153 "2"^^ . _:b482085089 . _:b482086152 "2"^^ . _:b482086155 "2"^^ . . . _:b482086154 "2"^^ . _:b482083751 . . . _:b482086165 "2"^^ . _:b482084108 . _:b482083438 . _:b482086164 "2"^^ . _:b482084147 . . _:b482086167 "2"^^ . _:b482086166 "2"^^ . _:b482086383 . _:b482086161 "2"^^ . . _:b482086456 . . _:b482086160 "2"^^ . _:b482084089 . _:b482086163 "2"^^ . _:b482086162 "2"^^ . . _:b482086173 "2"^^ . _:b482083361 . _:b482086172 "2"^^ . _:b482086237 . _:b482086175 "2"^^ . _:b482083217 . . _:b482086174 "2"^^ . . _:b482086169 "2"^^ . _:b482086168 "2"^^ . _:b482086171 "2"^^ . . . _:b482086170 "2"^^ . _:b482084613 . _:b482084612 . _:b482086181 "2"^^ . _:b482084615 . _:b482086180 "2"^^ . . _:b482084107 . _:b482084614 . _:b482086183 "2"^^ . _:b482084609 . _:b482086182 "2"^^ . . _:b482084608 . _:b482086177 "2"^^ . . _:b482084611 . _:b482086176 "2"^^ . _:b482083906 . _:b482084610 . _:b482086179 "2"^^ . _:b482084621 . _:b482086178 "2"^^ . . _:b482085985 . _:b482084620 . _:b482086189 "2"^^ . . _:b482084623 . _:b482086276 . _:b482086188 "2"^^ . _:b482085669 . _:b482084622 . _:b482086191 "2"^^ . _:b482083459 . . _:b482084617 . _:b482086190 "2"^^ . _:b482084616 . _:b482086185 "2"^^ . _:b482084619 . _:b482086184 "2"^^ . _:b482084260 . _:b482086164 . _:b482084618 . _:b482086187 "2"^^ . . _:b482084629 . _:b482086186 "2"^^ . . _:b482086051 . _:b482084628 . _:b482086197 "2"^^ . _:b482085651 . . _:b482084631 . _:b482086196 "2"^^ . _:b482085310 . _:b482084630 . _:b482086199 "2"^^ . _:b482083645 . _:b482084625 . _:b482086198 "2"^^ . . _:b482084624 . _:b482086193 "2"^^ . _:b482085156 . _:b482083324 . _:b482085397 . _:b482084627 . _:b482086192 "2"^^ . _:b482085715 . _:b482084754 . _:b482086195 "2"^^ . _:b482084626 . . . _:b482084637 . _:b482086194 "2"^^ . _:b482083866 . _:b482084636 . _:b482086205 "2"^^ . . _:b482084639 . _:b482086204 "2"^^ . _:b482085276 . _:b482084638 . _:b482086207 "2"^^ . . . _:b482084633 . _:b482086206 "2"^^ . _:b482084688 . _:b482086161 . _:b482084469 . _:b482084632 . _:b482086201 "2"^^ . . . _:b482084635 . _:b482086200 "2"^^ . _:b482086221 . _:b482085811 . _:b482084634 . _:b482086203 "2"^^ . . _:b482084645 . _:b482086202 "2"^^ . _:b482084773 . _:b482085300 . _:b482084644 . _:b482086213 "2"^^ . _:b482085798 . . _:b482084647 . _:b482086212 "2"^^ . . _:b482084646 . _:b482086215 "2"^^ . . _:b482083857 . _:b482084641 . _:b482086214 "2"^^ . _:b482084993 . _:b482084640 . _:b482086209 "2"^^ . _:b482085160 . _:b482084643 . _:b482086208 "2"^^ . _:b482083565 . _:b482086405 . . _:b482084642 . _:b482086211 "2"^^ . . _:b482084653 . _:b482086210 "2"^^ . . . . _:b482084652 . _:b482086221 "2"^^ . _:b482084655 . _:b482086220 "2"^^ . _:b482084654 . _:b482086223 "2"^^ . _:b482084649 . _:b482086222 "2"^^ . _:b482084648 . _:b482086217 "2"^^ . . . _:b482084651 . _:b482086216 "2"^^ . _:b482084650 . _:b482086219 "2"^^ . . . _:b482084661 . _:b482086218 "2"^^ . . . _:b482085980 . _:b482084660 . _:b482086229 "2"^^ . _:b482084781 . _:b482084663 . _:b482086228 "2"^^ . _:b482083413 . . _:b482086114 . _:b482084662 . _:b482086231 "2"^^ . . _:b482086227 . _:b482085293 . _:b482084657 . _:b482086230 "2"^^ . . _:b482084849 . _:b482084656 . _:b482086225 "2"^^ . _:b482084659 . _:b482086224 "2"^^ . _:b482084658 . _:b482086227 "2"^^ . . _:b482084176 . _:b482084705 . _:b482084669 . _:b482086226 "2"^^ . . _:b482084668 . _:b482086237 "2"^^ . _:b482084671 . _:b482086236 "2"^^ . . . . _:b482084670 . _:b482086239 "2"^^ . _:b482084665 . _:b482086238 "2"^^ . . _:b482084198 . _:b482084664 . _:b482086233 "2"^^ . . . _:b482084667 . _:b482086232 "2"^^ . . . _:b482084666 . _:b482086235 "2"^^ . . _:b482084677 . _:b482086234 "2"^^ . _:b482084676 . _:b482086245 "2"^^ . . . _:b482084605 . _:b482084679 . _:b482086244 "2"^^ . _:b482084678 . _:b482086247 "2"^^ . . . _:b482084673 . _:b482086246 "2"^^ . . . _:b482084672 . _:b482086241 "2"^^ . . _:b482084675 . _:b482086240 "2"^^ . . _:b482084674 . _:b482086243 "2"^^ . . _:b482084804 . . . _:b482084685 . _:b482086242 "2"^^ . _:b482084684 . _:b482086253 "2"^^ . _:b482084143 . _:b482084573 . . _:b482084687 . _:b482086252 "2"^^ . _:b482085576 . _:b482084686 . _:b482086255 "2"^^ . _:b482084681 . _:b482086254 "2"^^ . _:b482084680 . _:b482086249 "2"^^ . . _:b482086004 . . _:b482084683 . _:b482086248 "2"^^ . _:b482083905 . . _:b482084682 . _:b482086251 "2"^^ . . _:b482086402 . . _:b482083804 . _:b482086250 "2"^^ . . _:b482084693 . _:b482083179 . _:b482086029 . . _:b482085406 . _:b482084692 . _:b482086261 "2"^^ . . . _:b482084695 . _:b482086260 "2"^^ . . _:b482084694 . 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_:b482084459 . _:b482085512 "2"^^ . _:b482085419 . _:b482084458 . _:b482085515 "2"^^ . _:b482085992 . _:b482084469 . _:b482085514 "2"^^ . _:b482084468 . _:b482085525 "2"^^ . _:b482084471 . _:b482085524 "2"^^ . _:b482084470 . _:b482085527 "2"^^ . _:b482084465 . _:b482085526 "2"^^ . _:b482084464 . _:b482085521 "2"^^ . _:b482085560 . _:b482084467 . _:b482085520 "2"^^ . _:b482086527 . _:b482084466 . _:b482085523 "2"^^ . . _:b482084477 . _:b482085522 "2"^^ . _:b482085338 . _:b482084476 . _:b482085533 "2"^^ . _:b482083188 . _:b482084479 . _:b482085532 "2"^^ . _:b482084478 . _:b482085535 "2"^^ . _:b482084465 . _:b482084473 . _:b482085534 "2"^^ . . _:b482085508 . _:b482084472 . _:b482085529 "2"^^ . . _:b482084475 . _:b482085528 "2"^^ . _:b482084117 . _:b482084474 . _:b482085531 "2"^^ . _:b482084538 . _:b482084485 . _:b482085530 "2"^^ . . _:b482084484 . _:b482085541 "2"^^ . _:b482084487 . _:b482085540 "2"^^ . _:b482084683 . . _:b482085543 "2"^^ . _:b482084486 . _:b482084481 . _:b482085542 "2"^^ . _:b482086283 . . _:b482084480 . _:b482085537 "2"^^ . _:b482084483 . _:b482085536 "2"^^ . _:b482085519 . _:b482084482 . _:b482085539 "2"^^ . . _:b482083325 . . _:b482084493 . _:b482085538 "2"^^ . . . _:b482084492 . _:b482085549 "2"^^ . _:b482084495 . _:b482085548 "2"^^ . _:b482085423 . . . _:b482083220 . _:b482085551 "2"^^ . _:b482084494 . . _:b482084489 . _:b482085550 "2"^^ . . _:b482085545 "2"^^ . _:b482084488 . . _:b482085495 . . . _:b482084491 . _:b482085544 "2"^^ . _:b482084490 . _:b482085547 "2"^^ . _:b482083340 . _:b482084501 . _:b482085546 "2"^^ . _:b482084500 . _:b482085557 "2"^^ . . _:b482084746 . _:b482084503 . _:b482085556 "2"^^ . _:b482086509 . _:b482084502 . _:b482085559 "2"^^ . _:b482084627 . _:b482084497 . _:b482085558 "2"^^ . _:b482085690 . . _:b482084496 . _:b482085553 "2"^^ . _:b482084499 . _:b482085552 "2"^^ . _:b482084994 . _:b482085961 . _:b482084498 . _:b482085555 "2"^^ . _:b482084509 . _:b482085554 "2"^^ . _:b482084739 . _:b482085431 . _:b482084508 . _:b482085565 "2"^^ . _:b482084353 . _:b482084511 . _:b482085564 "2"^^ . _:b482083342 . _:b482084510 . _:b482085567 "2"^^ . _:b482083471 . _:b482086439 . _:b482086162 . _:b482084505 . _:b482085566 "2"^^ . _:b482084504 . _:b482085561 "2"^^ . _:b482084507 . _:b482085560 "2"^^ . _:b482084091 . _:b482085292 . . _:b482085563 "2"^^ . _:b482084506 . _:b482083226 . _:b482084517 . _:b482085562 "2"^^ . . _:b482083550 . _:b482084165 . _:b482084516 . _:b482085573 "2"^^ . _:b482084988 . . _:b482084519 . _:b482085572 "2"^^ . _:b482084518 . _:b482085575 "2"^^ . . _:b482084727 . _:b482085574 "2"^^ . _:b482084513 . _:b482084512 . _:b482085569 "2"^^ . _:b482084515 . _:b482085568 "2"^^ . _:b482084514 . _:b482085571 "2"^^ . _:b482085324 . _:b482084525 . _:b482085570 "2"^^ . _:b482084661 . _:b482085700 . _:b482084524 . _:b482085581 "2"^^ . _:b482084527 . _:b482085580 "2"^^ . _:b482084174 . _:b482084526 . _:b482085583 "2"^^ . _:b482084337 . _:b482084521 . _:b482085582 "2"^^ . _:b482084520 . _:b482085577 "2"^^ . _:b482084367 . _:b482084523 . _:b482086198 . _:b482085576 "2"^^ . . _:b482085579 "2"^^ . _:b482084522 . _:b482084533 . _:b482085578 "2"^^ . _:b482084532 . _:b482085589 "2"^^ . . _:b482084817 . _:b482083713 . _:b482084535 . _:b482085588 "2"^^ . _:b482084534 . _:b482085591 "2"^^ . _:b482084529 . _:b482085590 "2"^^ . _:b482085915 . _:b482084528 . _:b482085585 "2"^^ . . _:b482086121 . _:b482084531 . _:b482085584 "2"^^ . _:b482084530 . _:b482085587 "2"^^ . _:b482084541 . _:b482085586 "2"^^ . . _:b482084540 . _:b482085597 "2"^^ . _:b482085762 . _:b482084543 . _:b482085596 "2"^^ . . . _:b482084542 . _:b482085599 "2"^^ . _:b482083908 . _:b482084537 . _:b482086318 . _:b482085598 "2"^^ . _:b482083449 . _:b482084536 . _:b482085593 "2"^^ . _:b482084531 . _:b482084168 . _:b482086099 . _:b482084539 . _:b482085592 "2"^^ . _:b482084538 . _:b482085595 "2"^^ . . . _:b482084587 . _:b482085032 . _:b482084549 . _:b482085594 "2"^^ . _:b482083455 . _:b482084548 . _:b482085605 "2"^^ . _:b482084551 . _:b482085604 "2"^^ . . . . _:b482085607 "2"^^ . . _:b482084550 . _:b482084545 . _:b482085606 "2"^^ . _:b482084544 . _:b482085601 "2"^^ . . _:b482084547 . _:b482085600 "2"^^ . _:b482084546 . _:b482085603 "2"^^ . _:b482084755 . _:b482083349 . _:b482084557 . _:b482085602 "2"^^ . _:b482084556 . _:b482085613 "2"^^ . _:b482085358 . _:b482084559 . _:b482085612 "2"^^ . _:b482084558 . _:b482085615 "2"^^ . _:b482084553 . _:b482085614 "2"^^ . _:b482084552 . _:b482085609 "2"^^ . _:b482083369 . . . _:b482084555 . _:b482085608 "2"^^ . _:b482085162 . _:b482083631 . _:b482084554 . _:b482085611 "2"^^ . . _:b482084565 . _:b482085610 "2"^^ . _:b482084959 . _:b482084898 . . _:b482084564 . _:b482085621 "2"^^ . . _:b482083469 . _:b482084567 . _:b482085620 "2"^^ . . _:b482084566 . _:b482085623 "2"^^ . _:b482084519 . _:b482085622 "2"^^ . _:b482084561 . _:b482084560 . _:b482085617 "2"^^ . _:b482084563 . _:b482085616 "2"^^ . _:b482086291 . _:b482084562 . _:b482085619 "2"^^ . _:b482086225 . _:b482084573 . _:b482085618 "2"^^ . . . _:b482085629 "2"^^ . _:b482084572 . . _:b482084575 . _:b482085628 "2"^^ . . . _:b482086132 . _:b482084574 . _:b482085631 "2"^^ . . . _:b482084569 . _:b482085630 "2"^^ . _:b482084568 . _:b482085625 "2"^^ . _:b482084291 . _:b482083768 . _:b482085624 "2"^^ . _:b482084571 . . _:b482084355 . _:b482083876 . . . _:b482085627 "2"^^ . _:b482085005 . _:b482084570 . . _:b482085482 . _:b482083935 . _:b482084568 . _:b482084591 . _:b482085626 "2"^^ . _:b482084581 . _:b482086272 . _:b482084580 . _:b482085637 "2"^^ . _:b482083970 . _:b482084583 . _:b482085636 "2"^^ . . _:b482083806 . _:b482084582 . _:b482085639 "2"^^ . _:b482084577 . _:b482085638 "2"^^ . _:b482085759 . _:b482084669 . _:b482084576 . _:b482085633 "2"^^ . _:b482084579 . _:b482085632 "2"^^ . _:b482085389 . _:b482084578 . _:b482085635 "2"^^ . . . . . _:b482084589 . _:b482085634 "2"^^ . _:b482084588 . _:b482085645 "2"^^ . . _:b482084591 . _:b482085644 "2"^^ . _:b482086118 . _:b482084590 . _:b482085647 "2"^^ . _:b482083374 . _:b482084585 . _:b482085646 "2"^^ . . _:b482084584 . _:b482085641 "2"^^ . . _:b482084587 . _:b482085640 "2"^^ . . . _:b482084586 . _:b482085643 "2"^^ . _:b482084597 . _:b482085642 "2"^^ . . . . _:b482084596 . _:b482085653 "2"^^ . _:b482085334 . _:b482084599 . _:b482085653 . _:b482085652 "2"^^ . _:b482084983 . _:b482084598 . _:b482085655 "2"^^ . _:b482083546 . _:b482083731 . _:b482085654 "2"^^ . _:b482085304 . _:b482084593 . _:b482084304 . _:b482084592 . _:b482085649 "2"^^ . _:b482085573 . _:b482084516 . _:b482084595 . _:b482085648 "2"^^ . _:b482085216 . _:b482084594 . _:b482085651 "2"^^ . _:b482085315 . _:b482084605 . _:b482085650 "2"^^ . _:b482084604 . _:b482085661 "2"^^ . _:b482084607 . _:b482085660 "2"^^ . . _:b482084759 . _:b482084606 . _:b482085663 "2"^^ . _:b482084601 . _:b482085662 "2"^^ . _:b482086455 . . _:b482084600 . _:b482085657 "2"^^ . _:b482084603 . _:b482085656 "2"^^ . _:b482085393 . _:b482084602 . _:b482085659 "2"^^ . _:b482084101 . _:b482086413 . _:b482085658 "2"^^ . _:b482084100 . _:b482085669 "2"^^ . _:b482084680 . _:b482085668 "2"^^ . _:b482084103 . . _:b482084102 . _:b482085671 "2"^^ . _:b482085161 . _:b482084097 . _:b482085670 "2"^^ . . _:b482085665 "2"^^ . _:b482084096 . . . _:b482085664 "2"^^ . _:b482084099 . . . _:b482085667 "2"^^ . _:b482084098 . _:b482084109 . _:b482085666 "2"^^ . . _:b482084108 . _:b482085677 "2"^^ . _:b482084111 . _:b482085676 "2"^^ . _:b482085247 . _:b482084110 . _:b482085679 "2"^^ . _:b482084201 . _:b482085678 "2"^^ . _:b482084105 . _:b482084104 . _:b482085673 "2"^^ . . _:b482083492 . _:b482084107 . _:b482085672 "2"^^ . . . _:b482086309 . _:b482084106 . _:b482085675 "2"^^ . _:b482085685 . _:b482084117 . _:b482086021 . _:b482085674 "2"^^ . _:b482084116 . _:b482085685 "2"^^ . _:b482084119 . _:b482085684 "2"^^ . . . _:b482084118 . _:b482085687 "2"^^ . _:b482085151 . _:b482086477 . _:b482084113 . _:b482085686 "2"^^ . . . _:b482084112 . _:b482085681 "2"^^ . _:b482085062 . _:b482084115 . _:b482085680 "2"^^ . _:b482085198 . _:b482085147 . _:b482084114 . _:b482085683 "2"^^ . _:b482084477 . . _:b482084125 . _:b482085739 . _:b482085682 "2"^^ . . . . _:b482084124 . _:b482085693 "2"^^ . . _:b482084127 . _:b482086223 . _:b482085692 "2"^^ . _:b482085456 . _:b482084126 . _:b482085695 "2"^^ . . _:b482084121 . _:b482085694 "2"^^ . . _:b482084120 . _:b482085689 "2"^^ . _:b482084949 . _:b482084123 . _:b482085688 "2"^^ . _:b482084122 . _:b482085691 "2"^^ . _:b482085052 . . _:b482084133 . _:b482085690 "2"^^ . . _:b482084132 . _:b482085701 "2"^^ . _:b482086211 . _:b482084135 . _:b482085700 "2"^^ . _:b482085263 . _:b482085981 . _:b482084134 . _:b482085703 "2"^^ . _:b482084173 . _:b482084866 . _:b482084129 . _:b482085702 "2"^^ . _:b482084128 . _:b482085697 "2"^^ . . . _:b482084131 . _:b482085696 "2"^^ . _:b482085810 . . _:b482084130 . _:b482086377 . _:b482085699 "2"^^ . _:b482084141 . _:b482085698 "2"^^ . _:b482084006 . _:b482084140 . _:b482085709 "2"^^ . _:b482085261 . _:b482084143 . _:b482085708 "2"^^ . . _:b482084142 . _:b482085711 "2"^^ . _:b482084415 . _:b482084137 . _:b482086367 . _:b482085710 "2"^^ . _:b482086521 . _:b482084136 . _:b482085705 "2"^^ . _:b482085723 . _:b482084139 . _:b482085704 "2"^^ . _:b482084138 . _:b482085707 "2"^^ . . _:b482085706 "2"^^ . _:b482084149 . _:b482084148 . _:b482085717 "2"^^ . _:b482083516 . _:b14077287 "A total of 413 somatic events from tiers 1 to 3 were validated (see Mardis et al.>>7<< for tier designations; Supplementary Fig. 1a, Supplementary Tables 4a and 5)." . . . _:b482084151 . _:b482085716 "2"^^ . _:b482085686 . _:b482084150 . _:b482085719 "2"^^ . _:b482084145 . _:b482085718 "2"^^ . _:b482084144 . _:b482085713 "2"^^ . . _:b482084147 . _:b482085712 "2"^^ . _:b482084146 . _:b482085715 "2"^^ . . _:b482084157 . _:b482085714 "2"^^ . _:b482084721 . _:b482085725 "2"^^ . . _:b482084156 . _:b482086363 . . . _:b482084159 . _:b482085724 "2"^^ . _:b482084158 . _:b482085727 "2"^^ . . _:b482085726 "2"^^ . _:b482084153 . . . _:b482085721 "2"^^ . _:b482084152 . . _:b482084155 . _:b482085720 "2"^^ . _:b482085125 . _:b482083893 . . . _:b482085723 "2"^^ . _:b482084154 . . . _:b482085722 "2"^^ . _:b482084165 . _:b482083533 . _:b482084164 . _:b482085733 "2"^^ . _:b482085416 . _:b482084167 . _:b482085732 "2"^^ . _:b482083242 . _:b482084166 . _:b482085735 "2"^^ . _:b482084161 . _:b482085734 "2"^^ . _:b482084160 . _:b482085729 "2"^^ . _:b482084795 . _:b482084163 . _:b482085728 "2"^^ . _:b482085603 . . _:b482084162 . _:b482085731 "2"^^ . _:b482084173 . _:b482085730 "2"^^ . . _:b482084172 . _:b482085741 "2"^^ . . _:b482084175 . _:b482085740 "2"^^ . _:b482084414 . _:b482084174 . _:b482085743 "2"^^ . . _:b482083483 . _:b482084169 . _:b482085742 "2"^^ . _:b482085231 . _:b482084168 . _:b482085737 "2"^^ . _:b482085116 . _:b482085800 . _:b482084171 . _:b482085736 "2"^^ . _:b482084170 . _:b482085739 "2"^^ . _:b482086536 . _:b482084181 . _:b482085738 "2"^^ . . _:b482084180 . _:b482085749 "2"^^ . . _:b482085748 "2"^^ . _:b482084083 . _:b482084183 . _:b482084955 . _:b482083964 . _:b482084182 . _:b482085751 "2"^^ . . _:b482084177 . _:b482085750 "2"^^ . _:b482084176 . _:b482085745 "2"^^ . _:b482084598 . _:b482084139 . _:b482085184 . _:b482084179 . _:b482085744 "2"^^ . . . _:b482084178 . _:b482085747 "2"^^ . . _:b482084189 . _:b482085746 "2"^^ . _:b482085716 . . . . . _:b482084188 . _:b482085757 "2"^^ . _:b482084191 . _:b482085756 "2"^^ . _:b482084190 . _:b482085759 "2"^^ . _:b482083618 . _:b482084185 . _:b482085758 "2"^^ . _:b482084184 . _:b482085753 "2"^^ . _:b482085542 . . _:b482084514 . _:b482085949 . _:b482084187 . _:b482085752 "2"^^ . _:b482084331 . _:b482086115 . _:b482084186 . _:b482085755 "2"^^ . _:b482083588 . _:b482084197 . _:b482085754 "2"^^ . _:b482086302 . _:b482083478 . . _:b482086046 . _:b482085765 "2"^^ . _:b482084196 . _:b482084199 . _:b482085764 "2"^^ . _:b482085857 . _:b482084198 . _:b482085767 "2"^^ . _:b482085920 . . _:b482084193 . _:b482086541 . _:b482085766 "2"^^ . . . "PMC0" . _:b482085761 "2"^^ . _:b482084192 . . . . _:b482084195 . _:b482085760 "2"^^ . . _:b482083254 . _:b482083561 . _:b482084194 . _:b482085763 "2"^^ . _:b482085598 . _:b482084205 . _:b482085762 "2"^^ . . _:b482084204 . _:b482085773 "2"^^ . . _:b482085772 "2"^^ . _:b482084207 . . _:b482086441 . _:b482084206 . _:b482085775 "2"^^ . . _:b482086314 . _:b482084201 . _:b482085774 "2"^^ . _:b482084200 . _:b482085769 "2"^^ . . _:b482084203 . _:b482085768 "2"^^ . . . . _:b482085771 "2"^^ . _:b482084427 . _:b482084202 . . _:b482085923 . _:b482084213 . _:b482085770 "2"^^ . . . _:b482084212 . _:b482085781 "2"^^ . _:b482084215 . _:b482085780 "2"^^ . . _:b482086388 . _:b482084214 . _:b482085783 "2"^^ . _:b482084209 . _:b482085782 "2"^^ . _:b482084212 . . _:b482085777 "2"^^ . _:b482084208 . _:b482084397 . _:b482084211 . _:b482085776 "2"^^ . _:b482084210 . _:b482085779 "2"^^ . _:b482084221 . _:b482085778 "2"^^ . . _:b482085789 "2"^^ . _:b482084220 . _:b482084223 . _:b482085788 "2"^^ . . 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. _:b482086495 . . _:b482083955 . _:b482085008 "2"^^ . . _:b482083954 . _:b482085011 "2"^^ . _:b482084634 . . _:b482085010 "2"^^ . _:b482083965 . _:b482083964 . _:b482085021 "2"^^ . . _:b482084863 . _:b482083967 . _:b482085020 "2"^^ . . _:b482083225 . . _:b482083966 . _:b482085023 "2"^^ . _:b482083961 . _:b482085022 "2"^^ . _:b482083960 . _:b482085017 "2"^^ . _:b482084194 . _:b482085016 "2"^^ . _:b482083963 . . _:b482085646 . _:b482083962 . _:b482085019 "2"^^ . . . _:b482083239 . _:b482083973 . _:b482085018 "2"^^ . . _:b482085154 . _:b482083972 . _:b482085029 "2"^^ . . _:b482083975 . _:b482085028 "2"^^ . . _:b482083974 . _:b482085031 "2"^^ . _:b482083969 . _:b482085849 . _:b482085030 "2"^^ . _:b482083968 . _:b482085025 "2"^^ . _:b482083971 . _:b482085024 "2"^^ . _:b482084526 . . _:b482083970 . _:b482085027 "2"^^ . _:b482083981 . _:b482085026 "2"^^ . _:b482083980 . _:b482085037 "2"^^ . _:b482083682 . _:b482083983 . _:b482085036 "2"^^ . _:b482083982 . _:b482085039 "2"^^ . . _:b482083977 . _:b482085038 "2"^^ . . _:b482086056 . _:b482083873 . _:b482083976 . _:b482085033 "2"^^ . _:b482083979 . _:b482085032 "2"^^ . . _:b482083978 . _:b482085035 "2"^^ . _:b482083607 . _:b482084075 . _:b482085809 . _:b482083989 . _:b482085034 "2"^^ . _:b482086556 . _:b482083988 . _:b482085045 "2"^^ . _:b482084369 . . _:b482085044 "2"^^ . _:b482083991 . _:b482083990 . _:b482085047 "2"^^ . . . . _:b482085425 . _:b482083985 . _:b482085046 "2"^^ . . . _:b482083984 . _:b482085041 "2"^^ . _:b482086554 . _:b482083987 . _:b482086253 . _:b482085040 "2"^^ . . . _:b482083986 . _:b482085043 "2"^^ . . . _:b482084954 . _:b482083997 . _:b482085042 "2"^^ . . . _:b482083996 . _:b482085053 "2"^^ . _:b482083351 . _:b482083999 . _:b482085052 "2"^^ . . _:b482084790 . _:b482085055 "2"^^ . _:b482083998 . . _:b482086000 . _:b482083993 . _:b482085054 "2"^^ . _:b482083992 . _:b482085049 "2"^^ . . _:b482083995 . _:b482085048 "2"^^ . _:b482086264 . _:b482083994 . _:b482085051 "2"^^ . _:b482084005 . _:b482085050 "2"^^ . _:b482084910 . _:b482084917 . _:b482084004 . _:b482085061 "2"^^ . . _:b482085060 "2"^^ . _:b482084007 . _:b482085321 . _:b482084006 . _:b482085063 "2"^^ . . _:b482083350 . _:b482083771 . . _:b482085207 . _:b482084001 . _:b482085062 "2"^^ . _:b482086496 . _:b482084000 . _:b482085057 "2"^^ . _:b482084748 . _:b482084231 . _:b482084003 . _:b482085056 "2"^^ . . _:b482083367 . _:b482084002 . _:b482085059 "2"^^ . _:b482084013 . _:b482085058 "2"^^ . _:b482084588 . _:b482084012 . _:b482085069 "2"^^ . . . _:b482083410 . . . _:b482084015 . _:b482085068 "2"^^ . _:b482085015 . _:b482084014 . _:b482085071 "2"^^ . . . _:b482085070 "2"^^ . _:b482084009 . . _:b482085536 . . _:b482084008 . _:b482085065 "2"^^ . . _:b482084936 . _:b482084011 . _:b482085064 "2"^^ . . _:b482084010 . _:b482085067 "2"^^ . _:b482084021 . _:b482085066 "2"^^ . _:b482084093 . . _:b482085077 "2"^^ . _:b482084020 . _:b482083570 . _:b482083878 . _:b482084023 . _:b482085076 "2"^^ . _:b482084161 . . _:b482084022 . _:b482085079 "2"^^ . . _:b482084017 . _:b482085078 "2"^^ . . . _:b482085073 "2"^^ . _:b482084016 . . _:b482083197 . _:b482083292 . _:b482084019 . _:b482085072 "2"^^ . . _:b482084018 . _:b482085075 "2"^^ . _:b482084029 . _:b482085074 "2"^^ . . _:b482085085 "2"^^ . _:b482084028 . . _:b482085084 "2"^^ . _:b482084031 . _:b482084030 . _:b482085767 . _:b482085087 "2"^^ . _:b482083260 . _:b482084036 . _:b482084025 . _:b482085086 "2"^^ . . _:b482084024 . _:b482085081 "2"^^ . _:b482083189 . . _:b482084027 . _:b482086531 . _:b482085080 "2"^^ . . _:b482084026 . _:b482085083 "2"^^ . _:b482084837 . . _:b482084037 . _:b482085082 "2"^^ . _:b14077310 . . _:b482084036 . _:b482085093 "2"^^ . . _:b482084039 . _:b482085092 "2"^^ . . . _:b482084038 . _:b482085095 "2"^^ . . . _:b482084223 . _:b482085372 . . _:b482084033 . _:b482085094 "2"^^ . _:b482084703 . . _:b482083265 . . _:b482085410 . _:b482084032 . _:b482085089 "2"^^ . _:b482083424 . . _:b482083249 . _:b482085088 "2"^^ . . _:b482084035 . . _:b482085429 . _:b482084034 . _:b482085091 "2"^^ . . _:b482084045 . _:b482085090 "2"^^ . _:b482084135 . _:b482084044 . _:b482085101 "2"^^ . _:b482084047 . _:b482085100 "2"^^ . . . _:b482084046 . _:b482085103 "2"^^ . _:b482084450 . . _:b14077291 . _:b482085102 "2"^^ . _:b482084041 . . _:b14077301 . _:b482084040 . _:b482085097 "2"^^ . . _:b482084043 . _:b482085096 "2"^^ . . . _:b482084042 . _:b482085099 "2"^^ . _:b482084995 . . _:b482084053 . _:b482085098 "2"^^ . _:b482084052 . _:b482085109 "2"^^ . . _:b482084055 . _:b482085108 "2"^^ . _:b482085341 . _:b482085208 . . _:b482084054 . _:b482085111 "2"^^ . . _:b482084339 . _:b482084049 . _:b482085110 "2"^^ . . . _:b482084048 . _:b482085105 "2"^^ . _:b482084051 . _:b482085104 "2"^^ . _:b482084290 . . _:b482085107 "2"^^ . _:b482084050 . _:b482086030 . _:b482084061 . _:b482085106 "2"^^ . . _:b482084060 . _:b482085117 "2"^^ . . _:b482084063 . _:b482085116 "2"^^ . _:b482085307 . _:b482084062 . _:b482085119 "2"^^ . _:b482084057 . _:b482085118 "2"^^ . . _:b482085113 "2"^^ . _:b482084056 . _:b482084059 . _:b482085112 "2"^^ . . _:b482084058 . _:b482085206 . _:b482085115 "2"^^ . _:b482084055 . . . _:b482085114 "2"^^ . _:b482084069 . . _:b482083479 . . _:b482085125 "2"^^ . _:b482083966 . _:b482084068 . . _:b482084071 . _:b482085124 "2"^^ . _:b482083959 . _:b482085127 "2"^^ . _:b482084070 . _:b482084065 . _:b482085126 "2"^^ . _:b482084064 . _:b482085121 "2"^^ . _:b482084067 . _:b482085120 "2"^^ . _:b482084066 . _:b482085123 "2"^^ . _:b482084077 . _:b482085122 "2"^^ . _:b482085699 . _:b482086474 . _:b482084076 . _:b482086445 . _:b482085133 "2"^^ . . _:b482085782 . _:b482085259 . _:b482084079 . _:b482085132 "2"^^ . _:b482084084 . _:b482085135 "2"^^ . _:b482084078 . _:b482084073 . _:b482085134 "2"^^ . . _:b482084072 . _:b482085129 "2"^^ . . _:b482084075 . _:b482085128 "2"^^ . . _:b482084060 . _:b482085131 "2"^^ . _:b482084074 . _:b482083216 . . _:b482084085 . _:b482085130 "2"^^ . . . _:b482084084 . _:b482085854 . _:b482085141 "2"^^ . _:b482084087 . _:b482085140 "2"^^ . . _:b482084086 . _:b482085143 "2"^^ . . _:b482083208 . _:b482086018 . _:b482085142 "2"^^ . _:b482084081 . . _:b482084080 . _:b482085137 "2"^^ . _:b482084506 . _:b482084083 . _:b482085136 "2"^^ . . . _:b482084082 . _:b482086277 . _:b482085139 "2"^^ . _:b482084093 . _:b482085138 "2"^^ . . _:b482084092 . _:b482085149 "2"^^ . _:b482085424 . _:b482083987 . _:b482085148 "2"^^ . _:b482084095 . _:b482083237 . _:b482085151 "2"^^ . _:b482084094 . _:b482086368 . _:b482084089 . _:b482085150 "2"^^ . _:b482086528 . _:b482084088 . _:b482085145 "2"^^ . . _:b482084091 . _:b482085144 "2"^^ . . _:b482083507 . _:b482085918 . _:b482084090 . _:b482085147 "2"^^ . _:b482083589 . _:b482085146 "2"^^ . _:b482084764 . _:b482084300 . _:b482083588 . _:b482085157 "2"^^ . . _:b482083591 . _:b482085156 "2"^^ . . _:b482083590 . _:b482085159 "2"^^ . _:b482084254 . _:b482083509 . _:b482084088 . _:b482085158 "2"^^ . _:b482083585 . . _:b482086045 . . _:b482083584 . _:b482085153 "2"^^ . _:b482083587 . _:b482085152 "2"^^ . _:b482083586 . _:b482085155 "2"^^ . . _:b482083597 . _:b482085154 "2"^^ . _:b482083596 . _:b482085165 "2"^^ . . _:b482083599 . _:b482085164 "2"^^ . _:b482083598 . _:b482085167 "2"^^ . . _:b482083444 . _:b482083593 . _:b482085166 "2"^^ . . _:b482083592 . _:b482085161 "2"^^ . . _:b482083595 . _:b482085624 . _:b482085160 "2"^^ . _:b482083594 . _:b482085850 . _:b482085163 "2"^^ . _:b482085343 . _:b482083605 . _:b482085162 "2"^^ . . _:b482086074 . _:b482083604 . _:b482085173 "2"^^ . _:b482083607 . _:b482085172 "2"^^ . _:b482083739 . _:b482083606 . _:b482085175 "2"^^ . . _:b482083601 . _:b482085174 "2"^^ . _:b482083600 . _:b482085169 "2"^^ . _:b482083603 . _:b482085168 "2"^^ . _:b482084557 . _:b482083897 . _:b482084524 . _:b482083602 . _:b482085171 "2"^^ . _:b482083482 . _:b482083613 . _:b482085170 "2"^^ . _:b482083612 . _:b482085181 "2"^^ . _:b482083615 . _:b482085180 "2"^^ . _:b482083742 . _:b482085183 "2"^^ . _:b482083614 . . _:b482084118 . _:b482083609 . _:b482085182 "2"^^ . _:b482083813 . . . _:b482083608 . _:b482085177 "2"^^ . . _:b482084104 . _:b482085176 "2"^^ . _:b482083611 . _:b482083610 . _:b482085179 "2"^^ . _:b482083820 . _:b482083621 . _:b482085178 "2"^^ . _:b482085731 . _:b482085654 . _:b482083620 . _:b482085189 "2"^^ . . _:b482085188 "2"^^ . _:b482083623 . _:b482086151 . _:b482083622 . _:b482085191 "2"^^ . _:b482084061 . _:b482083617 . _:b482085190 "2"^^ . . _:b482083616 . _:b482085185 "2"^^ . . _:b482084769 . _:b482085705 . _:b482083619 . _:b482085184 "2"^^ . _:b482083618 . _:b482085187 "2"^^ . _:b482083629 . _:b482085186 "2"^^ . _:b482083628 . _:b482085197 "2"^^ . _:b482083631 . _:b482085196 "2"^^ . . _:b482085199 "2"^^ . _:b482083630 . _:b482086329 . _:b482083625 . _:b482085198 "2"^^ . . _:b482083624 . _:b482085193 "2"^^ . . _:b482083273 . _:b482083627 . _:b482085192 "2"^^ . _:b482083626 . _:b482085195 "2"^^ . _:b482086050 . _:b482083637 . _:b482085194 "2"^^ . _:b482085090 . _:b482085073 . _:b482083636 . _:b482085205 "2"^^ . _:b482083639 . _:b482085204 "2"^^ . . _:b482083865 . _:b482085207 "2"^^ . _:b482083638 . _:b482085115 . _:b482084215 . . _:b482083633 . _:b482085206 "2"^^ . . _:b482083632 . _:b482085201 "2"^^ . _:b482083635 . _:b482085200 "2"^^ . . _:b482085203 "2"^^ . _:b482083634 . _:b482086017 . _:b482085602 . _:b482083645 . _:b482086526 . _:b482085202 "2"^^ . _:b482083644 . _:b482085213 "2"^^ . _:b482086203 . . _:b482083647 . _:b482085212 "2"^^ . . _:b482084796 . _:b482083646 . _:b482085215 "2"^^ . _:b482083641 . _:b482085214 "2"^^ . _:b482083640 . _:b482085209 "2"^^ . . _:b482085335 . _:b482083643 . _:b482085208 "2"^^ . _:b482084989 . _:b482086344 . _:b482083642 . _:b482085211 "2"^^ . _:b482085118 . . _:b482083653 . _:b482085210 "2"^^ . _:b482084879 . _:b482085221 "2"^^ . _:b482083652 . _:b482083655 . _:b482085220 "2"^^ . _:b482083654 . _:b482085223 "2"^^ . _:b482085196 . _:b482084870 . _:b482086159 . _:b482083649 . _:b482085222 "2"^^ . _:b482083648 . _:b482085217 "2"^^ . _:b482083309 . _:b482084016 . . _:b482083651 . _:b482085216 "2"^^ . _:b482083723 . . _:b482085994 . _:b482084325 . _:b482083650 . _:b482085219 "2"^^ . . _:b482085218 "2"^^ . _:b482083661 . . _:b482086234 . _:b482083660 . _:b482085229 "2"^^ . . _:b482083663 . _:b482085228 "2"^^ . _:b482083662 . _:b482085231 "2"^^ . _:b482083657 . _:b482085230 "2"^^ . _:b482083656 . _:b482085225 "2"^^ . _:b14077311 "methods summary" . _:b482083659 . _:b482085224 "2"^^ . . _:b482084374 . _:b482083658 . _:b482085227 "2"^^ . _:b482085596 . _:b482083669 . _:b482085226 "2"^^ . _:b482083668 . _:b482085237 "2"^^ . _:b482086517 . _:b482083671 . _:b482085236 "2"^^ . _:b482085256 . _:b482083670 . _:b482085239 "2"^^ . _:b482085768 . _:b482083665 . _:b482085238 "2"^^ . . _:b482083664 . _:b482085233 "2"^^ . . . _:b482083667 . _:b482085232 "2"^^ . _:b482083666 . _:b482085235 "2"^^ . _:b482083472 . _:b482084860 . _:b482083552 . _:b482085234 "2"^^ . _:b482083677 . _:b482085847 . _:b482083676 . _:b482085245 "2"^^ . _:b482083679 . _:b482085244 "2"^^ . _:b482083592 . _:b482085247 "2"^^ . _:b482083678 . _:b482086437 . _:b482084892 . _:b482085246 "2"^^ . _:b482083673 . _:b482085770 . _:b482086337 . _:b482083672 . _:b482085241 "2"^^ . _:b482086168 . _:b482086365 . _:b482083675 . _:b482085240 "2"^^ . . _:b482085445 . _:b482083544 . _:b482085243 "2"^^ . _:b482083674 . _:b482083685 . _:b482085242 "2"^^ . _:b482084346 . _:b482085660 . _:b482083684 . _:b482085253 "2"^^ . _:b482085465 . _:b482085460 . _:b482083687 . _:b482085252 "2"^^ . . _:b482086524 . _:b482083986 . _:b482084295 . _:b482085255 "2"^^ . _:b482083686 . . _:b482083681 . _:b482085254 "2"^^ . . . . _:b482083680 . _:b482086530 . _:b482085249 "2"^^ . _:b482083683 . _:b482085248 "2"^^ . _:b482083682 . _:b482085251 "2"^^ . _:b482083761 . . _:b482085250 "2"^^ . _:b482083693 . . . _:b482083692 . _:b482085261 "2"^^ . _:b482083695 . _:b482085260 "2"^^ . _:b482084054 . _:b482085559 . . _:b482086179 . . _:b482085263 "2"^^ . _:b482083694 . _:b482084488 . _:b482083709 . _:b482083689 . _:b482085262 "2"^^ . _:b482083688 . _:b482085257 "2"^^ . . _:b482083494 . . _:b482083691 . _:b482085256 "2"^^ . . _:b482083690 . _:b482085259 "2"^^ . _:b482083701 . _:b482085258 "2"^^ . _:b482084827 . _:b482083463 . _:b482085543 . . _:b482085269 "2"^^ . _:b482083700 . . _:b482083871 . _:b482085268 "2"^^ . _:b482083703 . _:b482083702 . _:b482085271 "2"^^ . _:b14077285 "whether clonal evolution contributes to relapse, we performed whole genome sequencing of primary tumor-relapse pairs and matched skin samples from 8 patients, including UPN 933124, whose primary tumor mutations were previously reported>>3<<. Informed consent explicit for whole genome sequencing was obtained for all patients on a protocol approved by the Washington University Medical School Institutional Review Board." . _:b482083697 . _:b482085270 "2"^^ . . _:b482083696 . _:b482086095 . _:b482085265 "2"^^ . _:b482083332 . . _:b482083978 . _:b482083699 . _:b482086240 . _:b482085264 "2"^^ . . _:b482083698 . _:b482085267 "2"^^ . _:b482085565 . . _:b482085266 "2"^^ . _:b482083709 . . _:b482083708 . _:b482085277 "2"^^ . _:b482083711 . _:b482085276 "2"^^ . _:b482083710 . _:b482085279 "2"^^ . _:b482083705 . _:b482085278 "2"^^ . . . _:b482083704 . _:b482085273 "2"^^ . _:b482084133 . _:b482083707 . _:b482085272 "2"^^ . _:b482083246 . . _:b482085275 "2"^^ . _:b482083706 . _:b482083409 . _:b482086196 . . _:b482085274 "2"^^ . _:b482083717 . . _:b482084154 . _:b482085285 "2"^^ . _:b482084581 . _:b482083716 . . _:b482083719 . _:b482085284 "2"^^ . . . _:b482083718 . _:b482085287 "2"^^ . . _:b482083713 . _:b482085286 "2"^^ . _:b482083712 . _:b482085281 "2"^^ . _:b482083733 . _:b482085867 . _:b482083715 . _:b482085280 "2"^^ . _:b482084483 . _:b482083714 . _:b482085283 "2"^^ . _:b482083725 . _:b482085282 "2"^^ . _:b482083724 . _:b482085293 "2"^^ . _:b482083353 . _:b482083727 . _:b482085292 "2"^^ . . _:b482083726 . _:b482085295 "2"^^ . _:b482083721 . _:b482085294 "2"^^ . _:b482083255 . _:b482083720 . _:b482085289 "2"^^ . . . _:b482083723 . _:b482085288 "2"^^ . . . . _:b482083722 . _:b482085291 "2"^^ . . _:b482083733 . _:b482085290 "2"^^ . _:b482084436 . _:b482083732 . _:b482085301 "2"^^ . _:b482083209 . . _:b482083735 . _:b482085300 "2"^^ . . _:b482085303 "2"^^ . _:b482083734 . _:b482083215 . _:b482085302 "2"^^ . _:b482083729 . _:b482083728 . _:b482085297 "2"^^ . . . . _:b482085296 "2"^^ . _:b482083731 . . _:b482084085 . _:b482083730 . _:b482085813 . _:b482085299 "2"^^ . . _:b482083604 . . . _:b482083741 . _:b482085298 "2"^^ . . _:b482085309 "2"^^ . _:b482083740 . . . . _:b482085308 "2"^^ . . _:b482083743 . _:b482083613 . _:b482084731 . . . _:b482085311 "2"^^ . _:b482083742 . . _:b482083737 . _:b482085310 "2"^^ . _:b482083736 . _:b482085305 "2"^^ . . _:b482085304 "2"^^ . _:b482083739 . _:b482083738 . _:b482085307 "2"^^ . _:b482084571 . _:b482083913 . _:b482083749 . _:b482085306 "2"^^ . _:b482083748 . _:b482085317 "2"^^ . _:b482083751 . _:b482085493 . _:b482085316 "2"^^ . _:b482083750 . _:b482085319 "2"^^ . _:b482083745 . _:b482085318 "2"^^ . _:b482083639 . _:b482083744 . _:b482085313 "2"^^ . . . _:b482085312 "2"^^ . _:b482083747 . . _:b482085315 "2"^^ . _:b482083746 . _:b482085056 . . _:b482086488 . _:b482083757 . _:b482085314 "2"^^ . . . _:b482086113 . . _:b482083423 . _:b482085325 "2"^^ . _:b482083756 . _:b482083759 . _:b482085324 "2"^^ . _:b482083758 . _:b482085327 "2"^^ . _:b482083753 . _:b482085326 "2"^^ . _:b482085067 . _:b482083752 . _:b482085321 "2"^^ . _:b482085199 . _:b482083755 . _:b482085320 "2"^^ . _:b482083754 . _:b482085323 "2"^^ . _:b482083765 . _:b482085322 "2"^^ . _:b482083764 . _:b482085333 "2"^^ . _:b482083954 . _:b482083767 . _:b482086452 . _:b482085332 "2"^^ . _:b482083766 . _:b482085335 "2"^^ . _:b482083761 . _:b482085334 "2"^^ . _:b482083760 . _:b482085329 "2"^^ . _:b482086399 . _:b482083763 . _:b482085328 "2"^^ . . _:b482086184 . _:b482083762 . _:b482085452 . _:b482085331 "2"^^ . . _:b482083773 . _:b482085330 "2"^^ . _:b482085202 . _:b482083772 . _:b482085341 "2"^^ . . _:b482083775 . _:b482085516 . _:b482085340 "2"^^ . _:b482083774 . _:b482085343 "2"^^ . _:b482085430 . _:b482083719 . _:b482085342 "2"^^ . _:b482083769 . _:b482083768 . _:b482086497 . _:b482085337 "2"^^ . . _:b482083771 . _:b482085336 "2"^^ . _:b482085534 . . _:b482083770 . _:b482085339 "2"^^ . _:b482083781 . _:b482085338 "2"^^ . . . _:b482083780 . _:b482085349 "2"^^ . _:b482084569 . _:b482085348 "2"^^ . _:b482083783 . . . _:b482085351 "2"^^ . _:b482083782 . _:b482083777 . _:b482085350 "2"^^ . . _:b482085345 "2"^^ . _:b482083776 . _:b482085881 . _:b482083779 . _:b482085344 "2"^^ . _:b482084109 . _:b482085347 "2"^^ . _:b482084941 . _:b482083778 . _:b482083635 . _:b482083605 . _:b482085346 "2"^^ . _:b482083789 . _:b482085521 . _:b482083788 . _:b482085357 "2"^^ . _:b482085278 . _:b482084278 . . _:b482085641 . _:b482085356 "2"^^ . _:b482083791 . _:b482084310 . . _:b482085359 "2"^^ . _:b482083790 . . _:b482083785 . _:b482085358 "2"^^ . . _:b482083784 . _:b482085353 "2"^^ . . _:b482083787 . _:b482085352 "2"^^ . . _:b482083786 . _:b482085355 "2"^^ . _:b482083902 . _:b482083263 . _:b482083797 . _:b482085354 "2"^^ . . _:b482083808 . _:b482084976 . . _:b482083796 . _:b482085365 "2"^^ . _:b482084018 . _:b482085937 . . _:b482085364 "2"^^ . _:b482084890 . _:b482083799 . _:b482083798 . _:b482085367 "2"^^ . . _:b482083793 . _:b482085366 "2"^^ . _:b482083792 . _:b482085361 "2"^^ . . _:b482083795 . _:b482085360 "2"^^ . . _:b482083794 . _:b482085363 "2"^^ . _:b482085665 . . _:b482085362 "2"^^ . _:b482083805 . _:b482083969 . _:b482083867 . . _:b482083804 . _:b482085373 "2"^^ . . _:b482083807 . _:b482085372 "2"^^ . _:b482084142 . . . _:b482084584 . _:b482085375 "2"^^ . _:b482083806 . . . . . _:b482085486 . _:b482085374 "2"^^ . _:b482083801 . _:b482083800 . _:b482085369 "2"^^ . _:b482083803 . _:b482085368 "2"^^ . _:b482083802 . _:b482085371 "2"^^ . . _:b482083813 . _:b482085370 "2"^^ . _:b482083812 . _:b482083815 . _:b482083182 . _:b482083251 . _:b482085928 . _:b482083814 . _:b482083809 . _:b482083808 . . _:b482083811 . _:b482083810 . . _:b482084871 . _:b482083821 . _:b482084219 . . _:b482083820 . _:b482083823 . _:b482083953 . . _:b482083822 . _:b482083817 . . . _:b482083816 . . . _:b482083793 . . . _:b482083819 . . . . _:b482083818 . . _:b482083829 . _:b482083487 . _:b482085974 . _:b482083828 . . _:b482083831 . _:b482083830 . _:b482084160 . . _:b482083825 . _:b482083805 . _:b482083824 . . _:b482083827 . . _:b482083826 . . _:b482083837 . _:b482083836 . . _:b482083839 . _:b482085138 . _:b482083838 . _:b482085749 . . _:b482083833 . _:b482086550 . _:b482083832 . _:b482083835 . _:b482083834 . _:b482086342 . _:b482083333 . _:b482083332 . _:b482083335 . _:b482083468 . . _:b482083334 . _:b482083329 . _:b482083328 . . . . _:b482083532 . _:b482083331 . _:b482083599 . . _:b482083330 . _:b482083341 . _:b482083420 . _:b482083340 . _:b482083343 . _:b482086224 . _:b482083342 . _:b482083337 . . _:b482083336 . . . . . _:b482084973 . _:b482083339 . _:b482083338 . _:b482083349 . _:b482084019 . _:b482083348 . _:b482084468 . . _:b482083351 . _:b482085085 . _:b482083350 . _:b482084028 . . _:b482083345 . _:b482083344 . _:b482085250 . . _:b482083347 . _:b482085117 . _:b482083346 . _:b482083308 . . _:b482083357 . _:b482085499 . _:b482083356 . _:b482086534 . _:b482083303 . _:b482083359 . . _:b482085227 . _:b482083358 . _:b482084284 . _:b482083353 . _:b482083352 . _:b482085476 . _:b482083355 . _:b482085513 . _:b482083354 . _:b482083365 . _:b482084678 . . _:b482084474 . _:b482083364 . . . _:b482083367 . . _:b482083366 . _:b482083511 . _:b482083361 . _:b482083661 . _:b482084045 . . _:b482083360 . _:b482083672 . _:b482083363 . _:b482085610 . _:b482083362 . _:b482085623 . . _:b482083373 . _:b482084742 . _:b482083372 . . _:b482083375 . _:b482085120 . . . . _:b482083374 . _:b482083369 . _:b482084046 . _:b482083368 . _:b482086345 . _:b482083371 . . _:b482083370 . . _:b482083381 . _:b482083616 . . _:b482086386 . _:b482083380 . _:b482083383 . . . _:b482083382 . _:b482083377 . _:b482083795 . _:b482083376 . . . _:b482083379 . _:b482083378 . _:b482083389 . _:b482085390 . _:b482084714 . . _:b482086352 . _:b482083846 . _:b482083388 . . . _:b482083391 . _:b482083602 . . . _:b482083390 . _:b482083385 . _:b482085448 . . . _:b482083384 . _:b482084074 . _:b482083387 . _:b482084071 . _:b482083386 . _:b482083802 . _:b482083397 . _:b482083396 . _:b482085575 . _:b482083399 . _:b482084449 . _:b482083398 . _:b482083393 . _:b482085088 . _:b482083392 . . . _:b482083395 . . . _:b482083394 . _:b482085631 . _:b482083405 . _:b482085563 . . _:b482083404 . . _:b482085828 . _:b482085547 . _:b482083407 . . _:b482083406 . _:b482083401 . _:b482083400 . _:b482084270 . _:b482083403 . . _:b482083402 . _:b482085408 . _:b482083413 . _:b482083412 . . _:b482083415 . _:b482083560 . _:b482084053 . _:b482084711 . _:b482083414 . . _:b482084422 . _:b482083409 . . _:b482083222 . _:b482086512 . _:b482083408 . _:b482083764 . _:b482083960 . _:b482083411 . _:b482083410 . . _:b482083421 . _:b482086235 . . _:b482083435 . _:b482083420 . _:b14077293 "In addition to mutations in known AML genes such as DNMT3A8, FLT39, NPM110, IDH>>17<<, IDH211, WT112, RUNX113,14, PTPRT3, PHF615, and ETV616 in these 8 patients, we also discovered novel, recurring mutations in WAC, SMC3, DIS3, DDX41, and DAXX using 200 AML cases whose exomes were sequenced as part of the The Cancer Genome" . . _:b482083486 . . _:b482083423 .