_:b496049863 . _:b496049516 "3"^^ . _:b496049862 . _:b496049519 "3"^^ . _:b496049857 . . _:b496049518 "3"^^ . _:b496050169 . _:b496049373 . _:b496049757 . _:b496049856 . _:b496049596 . _:b496049513 "3"^^ . _:b496050342 . _:b496049859 . . _:b496049512 "3"^^ . . _:b496049858 . _:b496049515 "3"^^ . _:b496049869 . _:b496050176 . _:b496049514 "3"^^ . _:b496049978 . _:b496049868 . _:b496049525 "3"^^ . _:b496049268 . _:b496049871 . _:b496049524 "3"^^ . _:b496049870 . . _:b496049527 "3"^^ . _:b496049865 . _:b496049526 "3"^^ . . _:b496049864 . _:b496049521 "3"^^ . _:b496049744 . . _:b496049867 . _:b16663555 "Recombinant human SIRT7 protein was purified from baculovirus-infected insect cells as described>>8<<." . _:b496049520 "3"^^ . _:b496049906 . _:b496049866 . _:b496049523 "3"^^ . _:b496049877 . _:b496049522 "3"^^ . . _:b496049876 . _:b496049533 "3"^^ . _:b496049879 . _:b496049532 "3"^^ . _:b496049654 . _:b496049878 . _:b496049620 . _:b496049535 "3"^^ . _:b496049510 . . _:b496049873 . _:b496049169 . _:b496049534 "3"^^ . _:b496049910 . _:b496049872 . _:b496049529 "3"^^ . _:b496049875 . _:b496049528 "3"^^ . . _:b496049874 . _:b496049531 "3"^^ . _:b496049885 . _:b496049148 . _:b496049530 "3"^^ . _:b496049149 . _:b496049150 . _:b496049913 . _:b496049151 . _:b496049884 . _:b496049761 . _:b496049541 "3"^^ . _:b496049147 . _:b496049887 . _:b496049882 . _:b496049540 "3"^^ . _:b496049692 . _:b496049886 . _:b496049543 "3"^^ . . . _:b496049881 . _:b496049542 "3"^^ . . . _:b496049880 . _:b496049537 "3"^^ . _:b496049548 . _:b496049883 . _:b496049536 "3"^^ . _:b496049882 . _:b496049539 "3"^^ . _:b496049893 . _:b496049538 "3"^^ . _:b496049565 . _:b496049365 . . _:b496049892 . _:b496049549 "3"^^ . _:b496049895 . _:b496049548 "3"^^ . _:b496049894 . _:b496049551 "3"^^ . . _:b496049889 . _:b496049550 "3"^^ . _:b16663546 "The SIRT7 target genes were identified by detecting the SIRT7 binding peaks within 3 kb upstream to 3 kb downstream of transcription start sites (TSS\u2019s) of RefSeq genes using CEAS>>35<<. In total, 253 target genes were identified, including 241 protein-coding genes. The GO analysis was performed using DAVID Bioinformatics Resources 6.7 (http://david.abcc.ncifcrf.gov) 39,40." . _:b496049888 . _:b496049545 "3"^^ . _:b496049891 . _:b496049544 "3"^^ . _:b496049690 . _:b496049890 . _:b496049547 "3"^^ . _:b496050372 . _:b496049901 . _:b496049546 "3"^^ . _:b496049719 . _:b496049987 . _:b496049900 . _:b496049557 "3"^^ . _:b496049903 . _:b496049556 "3"^^ . _:b496049675 . _:b496049902 . _:b496049559 "3"^^ . _:b496049251 . _:b496049897 . _:b496049558 "3"^^ . _:b496049896 . _:b496049553 "3"^^ . _:b496049899 . _:b496049552 "3"^^ . _:b496049898 . _:b496049555 "3"^^ . . _:b496049909 . _:b496049554 "3"^^ . _:b496050405 . _:b496049908 . _:b496049565 "3"^^ . _:b496049967 . _:b496049911 . _:b496049564 "3"^^ . . _:b496049366 . _:b496049910 . . _:b496049567 "3"^^ . . _:b496049905 . _:b496049566 "3"^^ . _:b496050042 . _:b496049904 . _:b496049561 "3"^^ . _:b496049349 . _:b496049907 . _:b496049560 "3"^^ . _:b496050192 . _:b496049908 . _:b496050283 . _:b496049906 . _:b496049563 "3"^^ . . _:b496050108 . _:b496049917 . _:b496050206 . . _:b496049562 "3"^^ . . _:b496049726 . _:b496050199 . _:b496049916 . _:b496049573 "3"^^ . _:b496049919 . _:b496049572 "3"^^ . . . _:b496049918 . _:b496049252 . _:b496049575 "3"^^ . . . _:b496049769 . _:b496049913 . "PMC0" . _:b496049574 "3"^^ . _:b496050388 . _:b496049912 . _:b496049569 "3"^^ . . _:b496049915 . _:b496049439 . _:b496049568 "3"^^ . _:b496049914 . . _:b496049571 "3"^^ . _:b496049413 . _:b496049570 "3"^^ . _:b496049412 . _:b496049581 "3"^^ . _:b496050161 . _:b496049415 . _:b496049580 "3"^^ . _:b496049414 . _:b496049583 "3"^^ . _:b16663554 "methods summary" . _:b496050212 . _:b496049409 . _:b496049582 "3"^^ . _:b496049408 . _:b496049577 "3"^^ . _:b496049411 . _:b496049576 "3"^^ . _:b496049891 . _:b496049795 . _:b496049217 . _:b496049410 . _:b496049579 "3"^^ . . _:b496049421 . _:b496049578 "3"^^ . _:b496049420 . _:b496049589 "3"^^ . _:b496049423 . _:b496049588 "3"^^ . _:b496049422 . _:b496049591 "3"^^ . _:b496049845 . _:b496049417 . _:b496049590 "3"^^ . _:b496049416 . _:b496049585 "3"^^ . . . _:b496049419 . _:b496049584 "3"^^ . _:b496049418 . . _:b496049587 "3"^^ . _:b496050078 . _:b496049429 . . _:b496049586 "3"^^ . _:b496049428 . _:b496049597 "3"^^ . _:b496049431 . _:b496049596 "3"^^ . _:b496049430 . _:b496049599 "3"^^ . _:b496049425 . _:b496049598 "3"^^ . _:b496049424 . . _:b496049593 "3"^^ . _:b496049427 . _:b496049210 . _:b496049592 "3"^^ . . _:b496049971 . . _:b496049426 . _:b496049595 "3"^^ . . _:b16663535 "ELK4 knockdown target sequences are as follows: ELK4 KD1, 5\u2019-CGACACAGACATTGATTCA-3\u2019; ELK4 KD2, 5\u2019-GAGAATGGAGGGAAAGATA-3\u2019, as previously described>>20<<. ELK1 knockdown target sequence: GATGTGAGTAGAAGAGTTA. GABP\u03B1 knockdown target sequence: TGAAGAAGCTCAAGTGATA. HDAC1 knockdown target sequences: HDAC1 KD1 5\u2019- AGAAAGACCCAGAGGAGAA-3\u2019, HDAC1 KD2 5\u2019-GCAAGCAGATGCAGAGATT-3\u2019. Double-stranded" . _:b496049437 . _:b496049594 "3"^^ . . _:b496049436 . _:b496049605 "3"^^ . _:b496050384 . _:b496049439 . _:b496049604 "3"^^ . . _:b496049446 . _:b496049438 . _:b496049607 "3"^^ . _:b496049831 . _:b496049433 . _:b496049606 "3"^^ . . _:b496049432 . _:b496049601 "3"^^ . _:b496049435 . . _:b496049600 "3"^^ . _:b496049923 . . _:b496049434 . _:b496049603 "3"^^ . _:b496049445 . _:b496049602 "3"^^ . _:b496049444 . _:b496049613 "3"^^ . _:b496049447 . _:b496049612 "3"^^ . _:b496049257 . . . _:b496049446 . _:b496049615 "3"^^ . . _:b496049441 . _:b496049614 "3"^^ . _:b496049440 . _:b496049609 "3"^^ . _:b496049403 . . _:b496049443 . . _:b496049608 "3"^^ . _:b496049442 . _:b496049611 "3"^^ . _:b496049453 . _:b496049610 "3"^^ . _:b496049452 . _:b496049621 "3"^^ . _:b496049704 . . _:b496049455 . . _:b496049620 "3"^^ . _:b496049454 . . _:b496049623 "3"^^ . _:b496049714 . _:b496049449 . _:b496049269 . _:b496049622 "3"^^ . _:b496049441 . _:b496049448 . _:b496049617 "3"^^ . . _:b496049451 . _:b496049616 "3"^^ . _:b496050323 . _:b496049450 . . _:b496049619 "3"^^ . . _:b496049229 . _:b496049461 . . _:b496049618 "3"^^ . _:b496049570 . _:b496050346 . _:b496049460 . _:b496050040 . _:b496049629 "3"^^ . _:b496049463 . _:b496049707 . _:b496049628 "3"^^ . _:b496049462 . _:b496049631 "3"^^ . _:b496049457 . _:b496049630 "3"^^ . _:b496049456 . . _:b496049625 "3"^^ . _:b496049459 . . _:b496049624 "3"^^ . . _:b496049458 . _:b496049622 . _:b496049627 "3"^^ . _:b496049469 . _:b496050250 . _:b496050379 . _:b496049626 "3"^^ . _:b496049468 . _:b496049637 "3"^^ . _:b496049471 . _:b496049636 "3"^^ . . _:b496049470 . _:b496049639 "3"^^ . . _:b496049548 . _:b496049465 . _:b496049549 . _:b496049638 "3"^^ . _:b496049550 . _:b496049551 . _:b496049544 . _:b496049464 . _:b496049545 . _:b496049633 "3"^^ . _:b496049546 . _:b496049829 . _:b496049547 . _:b496049540 . _:b496049467 . _:b496049541 . _:b496049632 "3"^^ . _:b496049542 . _:b496049708 . _:b496049543 . _:b496049536 . _:b496049466 . _:b496049537 . _:b496049635 "3"^^ . _:b496049538 . _:b16663541 "Acid-extracted total histones were subjected to chemical derivatization using D0-proionic anhydride and digestion with trypsin at a substrate to enzyme ratio of 10:1 for 6 hours at 37\u00B0C as previously described>>34<<. An additional round of propionylation was performed on the digested peptides, with one sample being derivatized with the same D0-propionic anhydride reagent, and the other being derivatized with D10-propionic anhydride for quantitative" . _:b496049539 . . _:b496049564 . _:b496049477 . _:b496049565 . _:b496049634 "3"^^ . _:b496049566 . _:b496049567 . _:b496049560 . _:b496049476 . _:b496049561 . _:b496049645 "3"^^ . _:b496049562 . _:b496049563 . _:b496049556 . _:b496049479 . _:b496049557 . _:b496049644 "3"^^ . _:b496049558 . _:b496049559 . _:b496049552 . _:b496049478 . _:b496049553 . _:b496049647 "3"^^ . _:b496049554 . _:b496049555 . _:b496049580 . _:b496049473 . . _:b496049581 . _:b496049646 "3"^^ . _:b496049582 . _:b496049583 . _:b496049576 . _:b496049472 . _:b496049577 . _:b496049641 "3"^^ . _:b496049578 . . _:b496049579 . _:b496049572 . . _:b496049475 . _:b496049573 . _:b496049640 "3"^^ . _:b496049574 . _:b496049575 . _:b496049568 . _:b496049474 . _:b496049569 . _:b496049643 "3"^^ . _:b496049962 . _:b496049570 . _:b496049571 . _:b496049596 . _:b496049485 . _:b496049597 . _:b496049642 "3"^^ . _:b496049598 . _:b496049599 . . _:b496049592 . _:b496049484 . _:b496049593 . _:b496049653 "3"^^ . _:b496049646 . _:b496049594 . _:b496049595 . _:b496049588 . _:b496049487 . _:b496049589 . _:b496049652 "3"^^ . _:b496049327 . _:b496049590 . _:b496049591 . _:b496049584 . _:b496049894 . _:b496049486 . . _:b496049655 "3"^^ . _:b496049585 . _:b496049586 . _:b496049587 . _:b496049612 . _:b496049481 . _:b496049613 . _:b496049654 "3"^^ . _:b496049452 . _:b496049614 . _:b496049615 . _:b496049683 . _:b496049608 . _:b496049480 . _:b496049609 . _:b496049649 "3"^^ . _:b496049610 . _:b496049611 . _:b496049604 . _:b496049483 . _:b496049605 . _:b496050370 . _:b496049648 "3"^^ . _:b496049805 . _:b496049606 . _:b496049433 . _:b496049607 . _:b496049600 . _:b496049482 . _:b496049601 . _:b496049651 "3"^^ . _:b496049602 . _:b496049603 . _:b496049628 . _:b496049493 . _:b496049629 . _:b496049650 "3"^^ . _:b496049630 . _:b496049631 . _:b496049314 . _:b496049624 . _:b496049492 . _:b496049625 . . _:b496049661 "3"^^ . _:b496049626 . _:b496049627 . . _:b496049620 . . _:b496049495 . _:b496049621 . _:b496049660 "3"^^ . _:b496049622 . _:b496049623 . _:b496049616 . _:b496049494 . _:b496049617 . _:b496049663 "3"^^ . _:b496049618 . _:b496049619 . _:b496050147 . _:b496049248 . _:b496049489 . _:b496049644 . _:b496049645 . _:b496049662 "3"^^ . _:b496049646 . _:b496049647 . _:b496049640 . _:b496049488 . _:b496049641 . _:b496049657 "3"^^ . _:b496049642 . _:b496049643 . . _:b496049636 . _:b496049491 . _:b496049637 . _:b496049656 "3"^^ . _:b496049638 . _:b496049639 . _:b496049632 . _:b496049490 . _:b496049633 . _:b496049659 "3"^^ . _:b496049634 . _:b496049331 . _:b496049635 . _:b496049660 . _:b496049501 . _:b496049661 . _:b496049658 "3"^^ . _:b496049662 . _:b496049663 . _:b496049656 . _:b496049500 . _:b496049657 . _:b496049658 . _:b496049659 . _:b496049652 . _:b496049503 . _:b496049653 . _:b496049654 . _:b496050131 . _:b496049655 . _:b496049648 . _:b496049502 . . _:b496049649 . _:b496049650 . _:b496049651 . _:b496049420 . _:b496049497 . _:b496049711 . _:b496049421 . _:b496049422 . _:b496049423 . _:b496049416 . _:b496049496 . _:b496049417 . . _:b496049418 . _:b496049419 . _:b496049412 . _:b496049499 . _:b496049413 . _:b496049414 . . _:b496049415 . _:b496049408 . . _:b496049498 . _:b496049409 . _:b496049878 . _:b496049410 . _:b496049411 . _:b496049436 . _:b496049509 . _:b496049437 . _:b496049438 . _:b496049439 . _:b496050185 . _:b496049432 . _:b496049508 . _:b496049433 . _:b496049274 . _:b496049434 . _:b496049435 . . _:b496049511 . . _:b496049428 . _:b496049429 . _:b496049430 . _:b496049431 . _:b496049424 . _:b496049510 . _:b496049425 . _:b496049426 . _:b496049427 . _:b496049452 . _:b496049505 . _:b496049453 . _:b496049454 . _:b496049455 . _:b496049448 . _:b496049504 . _:b496049449 . . _:b496049450 . . _:b496049451 . _:b496049444 . _:b496049507 . _:b496049445 . _:b496049446 . _:b496049447 . _:b496049440 . _:b496049506 . _:b496049441 . _:b496049442 . . _:b496049443 . _:b496049732 . _:b496049149 . _:b496049468 . _:b496049517 . _:b496049469 . _:b496049470 . _:b496049471 . _:b496049464 . _:b496049516 . _:b496049465 . _:b496049466 . _:b496049467 . _:b496049460 . _:b496049519 . _:b496049461 . _:b496049462 . _:b496049853 . _:b496049463 . _:b496049456 . _:b496049518 . _:b496049457 . _:b496049458 . _:b496049167 . _:b496049459 . _:b496049484 . _:b496049513 . _:b496049485 . _:b496049486 . _:b496049487 . _:b496049480 . _:b496049512 . _:b496049481 . _:b496049482 . . _:b496049483 . _:b496049476 . _:b496049515 . _:b496049837 . _:b496049477 . _:b496049478 . . _:b496049479 . _:b496049472 . _:b496049514 . _:b496049473 . _:b496049474 . _:b496049475 . _:b496050014 . _:b496049500 . _:b496049525 . _:b496049501 . _:b496049502 . . _:b496049503 . _:b496049496 . _:b496049524 . _:b496049497 . _:b496049498 . _:b496049499 . . _:b496049492 . _:b496049527 . _:b496049493 . _:b496049494 . _:b496049495 . _:b496049438 . _:b496049488 . _:b496049526 . . _:b496049489 . _:b496049490 . _:b496049491 . . _:b496049516 . _:b496049521 . _:b496049517 . _:b496049518 . _:b496049519 . . _:b496049512 . _:b496049520 . _:b496049513 . _:b496049514 . _:b496049515 . _:b496049508 . _:b496049523 . _:b496049509 . _:b496049510 . _:b496049511 . _:b496049504 . _:b496049522 . . _:b496049505 . _:b496049506 . _:b496050181 . _:b496049507 . _:b496049532 . _:b496049533 . _:b496049533 . _:b496049534 . _:b496050180 . _:b496049535 . _:b496049528 . _:b496049532 . _:b496049529 . _:b496049530 . _:b496050183 . _:b496049531 . _:b496049524 . _:b496049535 . . _:b496049525 . _:b496049526 . _:b496050182 . _:b496049527 . . _:b496049520 . _:b496049534 . _:b496049521 . _:b496049522 . _:b496050177 . _:b496049523 . _:b496049292 . _:b496049529 . _:b496049293 . _:b496049294 . _:b496050176 . _:b496049295 . _:b496049236 . _:b496050276 . _:b496049528 . _:b496049288 . _:b496049289 . _:b496049290 . _:b496050179 . _:b496049291 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_:b496049898 . _:b496050331 . _:b496049899 . _:b496049892 . _:b496049171 . _:b496049893 . _:b496049894 . _:b496050330 . _:b496049895 . _:b496049888 . _:b496049170 . _:b496049889 . _:b496049890 . _:b496050352 . _:b496050341 . _:b496049891 . _:b496049916 . _:b496049181 . _:b496049917 . _:b496049918 . _:b496050340 . _:b496049919 . . _:b496049912 . _:b496049540 . _:b496049180 . _:b496050103 . _:b496049913 . _:b496049914 . _:b496050343 . _:b496049915 . . _:b496049183 . _:b496049908 . _:b496049909 . _:b496049910 . _:b496050342 . _:b496049911 . _:b496049942 . _:b496049904 . _:b496049182 . _:b496049905 . _:b496049906 . _:b496050337 . _:b496049907 . _:b496049676 . _:b496049177 . _:b496049677 . _:b496049988 . _:b496049678 . _:b496050336 . _:b496049679 . _:b496049672 . _:b496049176 . _:b496049673 . _:b496049674 . _:b496050339 . . _:b496049675 . _:b496049668 . _:b496049179 . _:b496049669 . _:b496049670 . _:b496050338 . _:b496049671 . _:b496049664 . _:b496049178 . _:b496049665 . _:b496050189 . _:b496049666 . _:b496050349 . . _:b496049667 . . _:b496049692 . _:b496049189 . . _:b496049693 . _:b496049694 . _:b496050348 . . _:b496049695 . _:b496049688 . _:b496049188 . _:b496049689 . _:b496049690 . _:b496050351 . _:b496049691 . _:b496049684 . _:b496049191 . . _:b496049685 . . _:b496049686 . _:b496050350 . _:b496049354 . _:b496049687 . _:b496049680 . _:b496049190 . _:b496049681 . _:b496049682 . _:b496050345 . _:b496049683 . _:b496049708 . _:b496049185 . _:b496049709 . _:b496049710 . _:b496050344 . _:b496049711 . _:b496049704 . _:b496049184 . _:b496049666 . _:b496049705 . _:b496049706 . _:b496050347 . _:b496049707 . _:b496049697 . _:b496049424 . _:b496049700 . _:b496049187 . _:b496049701 . . _:b496049702 . _:b496050346 . _:b496049703 . _:b496049696 . _:b496049186 . _:b496049697 . _:b496049698 . _:b496050357 . _:b496049699 . _:b496049724 . _:b496049197 . _:b496049875 . _:b496049725 . _:b496049726 . _:b496050356 . _:b496049727 . _:b496049720 . _:b496049196 . _:b496049721 . _:b496049722 . _:b496050359 . _:b496049723 . _:b496049716 . _:b496049199 . _:b496049717 . _:b496049718 . _:b496050358 . _:b496049719 . _:b496049712 . _:b496049198 . _:b496049713 . _:b496049714 . _:b496050353 . _:b496049695 . _:b496049715 . _:b496049740 . _:b496049193 . _:b496049741 . _:b496049742 . _:b496050352 . _:b496049743 . _:b496049736 . _:b496049192 . _:b496049737 . _:b496049242 . _:b496049738 . _:b496050355 . _:b496049739 . _:b496049732 . _:b496049195 . _:b496049733 . _:b496049734 . _:b496050354 . _:b496049735 . _:b496049728 . _:b496049194 . _:b496050264 . _:b496049729 . _:b496049326 . _:b496050365 . _:b496049730 . _:b496049731 . _:b496049756 . _:b496049205 . _:b496049757 . _:b496049758 . _:b496050364 . _:b496049710 . _:b496049759 . _:b496049752 . _:b496049204 . _:b496049753 . _:b496049754 . _:b496050367 . _:b496049755 . _:b496049748 . _:b496049207 . _:b496049749 . _:b496049750 . _:b496050366 . _:b496049751 . _:b496049744 . _:b496049206 . _:b496049745 . _:b496049746 . _:b496050361 . . _:b496049747 . _:b496049772 . . _:b496049201 . _:b496049773 . _:b496049774 . _:b496050360 . _:b496049775 . _:b496049768 . _:b496049200 . _:b496049769 . _:b496049643 . _:b496050363 . _:b496049770 . _:b496049771 . _:b496049764 . _:b496049203 . _:b496049765 . _:b496049766 . _:b496050362 . _:b496049767 . _:b496049760 . _:b496049202 . _:b496049761 . _:b496049762 . _:b496050373 . _:b496049763 . _:b496049788 . _:b496049213 . _:b496049789 . _:b496049790 . _:b496050372 . _:b496049791 . _:b496049721 . _:b496049784 . _:b496049212 . _:b496049785 . _:b496049786 . _:b496050375 . _:b496049787 . _:b496049780 . _:b496049215 . _:b496049781 . . _:b496049782 . _:b496050374 . _:b496049783 . _:b496049776 . _:b496049214 . _:b496049777 . _:b496049778 . _:b496050369 . _:b496049779 . _:b496050215 . _:b496049209 . _:b496050368 . _:b496050170 . _:b496050191 . . _:b496049208 . _:b496049740 . _:b496050371 . _:b496049211 . _:b496050370 . . _:b496049210 . _:b496050381 . _:b496049221 . _:b496050380 . _:b496049220 . _:b496050383 . _:b496049223 . _:b496050382 . _:b496049629 . _:b496049222 . _:b496050377 . _:b496049217 . _:b496050376 . _:b496049216 . . _:b496050379 . _:b496049219 . _:b496050378 . _:b496049218 . _:b496050389 . _:b496049229 . _:b496050388 . _:b496049228 . _:b496049773 . _:b496050391 . . _:b496049231 . _:b496050390 . _:b496049230 . _:b496050311 . _:b496050385 . _:b496049225 . . _:b496050384 . _:b496049224 . _:b496050038 . _:b496050387 . _:b496049227 . _:b496050386 . _:b496049534 . _:b496049226 . _:b496050363 . _:b496050397 . _:b496049237 . _:b496050396 . _:b496049236 . _:b496050399 . _:b496049239 . . _:b496049852 . _:b496050398 . . _:b496049238 . _:b496050158 . _:b496050393 . _:b496049458 . _:b496049233 . _:b496049222 . . _:b496050392 . _:b496049994 . _:b496049232 . _:b496050395 . _:b16663552 . _:b496049235 . _:b496050394 . _:b496049234 . . _:b496050405 . _:b496049245 . _:b496050404 . _:b496049244 . . _:b496050407 . _:b496049247 . . _:b496049370 . _:b496050406 . _:b496049246 . _:b496050401 . _:b496049896 . _:b496049241 . _:b496050400 . _:b496049965 . . _:b496049240 . _:b496049550 . . _:b496050403 . _:b496049537 . _:b496049243 . _:b496050402 . _:b496049242 . _:b496049253 . _:b496049660 . _:b496049252 . _:b496049747 . _:b496049255 . _:b496049254 . _:b496049249 . . _:b496050408 . _:b496049248 . _:b496049413 . . _:b496049251 . _:b496049963 . _:b496049250 . _:b496050334 . . _:b496049261 . _:b496050293 . _:b496049260 . _:b496049263 . _:b496049262 . _:b496050114 . . . _:b496049257 . _:b496049256 . _:b496049259 . _:b496049975 . _:b496049644 . _:b496049258 . _:b496049269 . _:b496049268 . _:b496049271 . _:b496049552 . _:b496049270 . _:b496049265 . _:b496050130 . _:b496049264 . . _:b496049267 . _:b496050200 . _:b496049266 . _:b496049227 . _:b496049277 . _:b496049276 . _:b496049254 . _:b496049279 . _:b496049518 . _:b496049278 . _:b496049273 . _:b496049272 . . _:b496049275 . _:b496050380 . _:b496049274 . _:b496049285 . _:b496049284 . _:b496049348 . _:b496049265 . . _:b496049287 . . . _:b496049286 . _:b496049281 . _:b496049952 . _:b496049280 . . _:b496050011 . _:b496049554 . _:b496049283 . _:b496049282 . _:b496049293 . _:b496049292 . . _:b496049295 . . _:b496049294 . _:b496050308 . _:b496049289 . _:b496049288 . . _:b496049291 . _:b496049174 . . . _:b496049290 . _:b496049301 . . _:b496050260 . _:b496049300 . _:b496049303 . . _:b496049553 . _:b496049302 . . _:b496049297 . . _:b496049296 . _:b496049299 . _:b496049249 . _:b496050348 . _:b496049298 . . _:b496049652 . _:b496049309 . _:b496049308 . _:b496049311 . _:b496049310 . . _:b496049305 . . . _:b496049304 . . . _:b496049307 . _:b496049631 . _:b496049531 . _:b496049306 . . _:b496049317 . _:b496050037 . . _:b496049316 . _:b496049319 . _:b496049318 . . _:b496050355 . _:b496050280 . _:b496049313 . . _:b496049312 . . _:b496049315 . . . _:b496049314 . _:b496049325 . _:b496049324 . . _:b496049327 . _:b496049505 . _:b496049326 . _:b496049343 . _:b496049147 . _:b496049321 . _:b496049467 . _:b496049320 . _:b496049889 . . _:b496049642 . _:b496049323 . _:b496049897 . _:b496050290 . _:b496049322 . _:b496049333 . _:b496050289 . _:b496049332 . _:b496049335 . _:b496049334 . _:b496049329 . _:b496049539 . . _:b496049812 . _:b496049328 . _:b496049331 . _:b496049330 . _:b496049341 . . _:b496049340 . _:b496050230 . _:b496050341 . _:b496049243 . . _:b496049581 . _:b496049343 . _:b496049342 . . _:b496049973 . _:b496049337 . _:b496049483 . _:b496049336 . _:b496049339 . . _:b496049338 . _:b496049349 . _:b496049322 . _:b496049348 . _:b496049930 . _:b496049584 . . _:b496049351 . . _:b496049350 . . . _:b496049345 . _:b496049951 . _:b496049344 . . _:b496049347 . . _:b496050060 . _:b496049346 . _:b496049357 . _:b16663549 "For identification of ELK4 ChIP-sequencing target genes, the ChIP-sequencing reads from O'Geen et al. (GSE24685)>>16<<, were remapped to hg18, and peaks were called using MACS (Supplementary Table 9)." . . _:b496050378 . _:b496049356 . _:b496049359 . _:b496049358 . _:b496049879 . _:b496050313 . _:b496050238 . _:b496049353 . _:b496049352 . _:b496049457 . _:b496050257 . _:b496049909 . _:b496049355 . _:b496049922 . _:b496049354 . _:b496049365 . . _:b496049364 . _:b496049367 . _:b496049440 . _:b496049645 . _:b496049486 . _:b496049366 . . _:b496049361 . _:b496049784 . _:b496049360 . _:b496049932 . _:b496049363 . _:b496050121 . . _:b496049362 . _:b496049373 . . _:b496049372 . . _:b496049375 . _:b496049374 . _:b496049165 . _:b496049369 . _:b496049886 . _:b496049368 . _:b496049371 . _:b496049865 . _:b496049370 . _:b496049381 . _:b496049157 . . _:b496049380 . _:b496049447 . . _:b496049383 . _:b496050330 . _:b496049382 . . _:b496049377 . _:b496050152 . _:b496049376 . _:b496049379 . . _:b496049378 . _:b496049389 . _:b16663534 . _:b496049388 . _:b496049912 . _:b496050034 . _:b496049391 . _:b496049390 . . _:b496049385 . . . _:b496049384 . . _:b496049387 . _:b496049208 . . _:b496049386 . _:b496049397 . _:b496049396 . _:b496049566 . _:b496049399 . . _:b496050136 . _:b496050396 . . _:b496049417 . _:b496049398 . _:b496049393 . _:b496049223 . _:b496049226 . _:b496049392 . . _:b496049395 . _:b496049394 . _:b16663554 _:b16663556 . _:b496049405 . _:b496049404 . . _:b16663554 _:b16663555 . _:b496049407 . . _:b496049406 . _:b496049401 . _:b496049380 . . _:b496049400 . _:b496049403 . _:b496049402 . . . _:b496049197 . _:b496049640 . _:b496049601 . . _:b496050375 . . . _:b496050385 . _:b496049279 . _:b496049191 . _:b496049835 . _:b496049306 . . _:b496049807 . _:b496049767 . . _:b496049359 . _:b496050128 . . _:b496049733 . . . _:b496050019 . . _:b496050045 . _:b496050174 . _:b496049190 . . . _:b496049915 . _:b496049418 . . _:b496049275 . . . . . . _:b496049722 . _:b496050033 . . . _:b496049400 . _:b496050180 . . _:b496049864 . . . _:b496050365 . _:b496050030 . . _:b496049247 . _:b496049277 . . _:b496049149 "32"^^ . . _:b496049148 "38"^^ . _:b496049762 . _:b496049150 "30"^^ . . _:b496049501 . . . _:b496049147 "39"^^ . _:b496049698 . . _:b496050100 . _:b496049499 . . . _:b496050374 . _:b496050247 . _:b16663536 . _:b496049183 . . . _:b496049607 . _:b496049154 . _:b496050066 . . _:b496049626 . . _:b496049734 . . . _:b496049284 . . _:b496050246 . . . _:b496049151 "26"^^ . _:b496050032 . . _:b496049324 . . . _:b496049462 . . _:b496049810 . _:b496049904 . _:b496049676 . . . _:b496050124 . _:b496049585 . _:b496050039 . _:b496049995 . _:b496049180 . . . _:b496049657 . _:b496049944 . . . . . _:b496050005 . _:b496049790 . . _:b496049560 . _:b496050369 . _:b496049484 . _:b496050314 . _:b496050301 . _:b496050127 . _:b496049627 . . _:b496049685 . _:b496049758 . _:b496049786 . . . . _:b496049777 . _:b496050137 . _:b496049179 . . _:b496050226 . . _:b496049158 . _:b16663542 "was performed on the digested peptides, with one sample being derivatized with the same D0-propionic anhydride reagent, and the other being derivatized with D10-propionic anhydride for quantitative proteomics as previously described>>35<<. D10-propionic anhydride introduces a 5 Da shift by derivatization of the free N-termini of all peptides generated from the trypsin digest." . _:b496050214 . . . _:b496049924 . . . _:b496050053 . . _:b496049340 . _:b496049672 . _:b496050315 . . . _:b496050105 . _:b496049527 . . _:b496050382 . _:b496049187 . _:b496049325 . _:b496049850 . . . _:b496049968 . _:b496050190 . _:b496049383 . _:b496049898 . _:b496050194 . . _:b496050235 . . _:b496049658 . _:b496050364 . . _:b496049189 . . _:b496049347 . . _:b496049371 . _:b496049667 . _:b496049899 . . . . . . . . _:b496049588 . . _:b496049544 . _:b496049311 . _:b496049760 . _:b496049465 . . _:b16663551 . . _:b496049212 . . . _:b496049405 . _:b496049947 . . _:b496049428 . . . . _:b496050133 . _:b496049993 . . _:b496050255 . _:b496050291 . _:b496049905 . . _:b496049381 . _:b496049653 . . _:b496049367 . . _:b496049205 . . . _:b496049281 . _:b496050109 . _:b496049155 . _:b496049204 . . _:b496050036 . . . _:b16663548 "The GO analysis was performed using DAVID Bioinformatics Resources 6.7 (http://david.abcc.ncifcrf.gov) 39,>>40<<." . . . . . . . _:b496049871 . . . _:b496050273 . _:b496049921 . _:b496050055 . . . _:b496049328 . . . . . _:b496050392 . . _:b496050143 . . . . _:b496049235 . . . . _:b496049342 . . _:b496049234 . _:b496049637 . . _:b496049415 . _:b496049149 . _:b496049956 . _:b496049148 . _:b496049728 . . _:b496049151 . _:b496050018 . _:b496049150 . . _:b496049754 . _:b16663543 . . _:b496049199 . _:b496049147 . _:b496050403 . _:b496050254 . _:b496050183 . . _:b496049701 . . . _:b496050087 . . . . . . _:b496049278 . _:b496049870 . . . . . _:b496050387 . _:b16663537 . . _:b496050111 . _:b496049750 . . . _:b496049813 . . _:b496049260 . _:b496049487 . _:b496049858 . _:b496049669 . _:b496050282 . _:b496050095 . . . . _:b496049935 . _:b496049156 . _:b496049363 . _:b496049656 . . _:b496050279 . . _:b496050390 . . _:b496050188 . _:b496049759 . . . _:b496049938 . _:b496050008 . _:b496049895 . _:b496049702 . . _:b496050358 . . . . . . . _:b496049228 . . _:b16663538 "Co-immunoprecipitations were performed as previously described>>32<<, except that one 150 mm plate of cells was used per IP, Protein A/G beads (Sigma) were used instead of FLAG-resin, and elution was performed by boiling beads in Laemmli loading buffer." . _:b496050296 . . . . . _:b496050181 . _:b496049706 . . _:b496049216 . _:b496049641 . _:b496049928 . . . _:b496049856 . . _:b496049153 . . _:b496049293 . _:b496049573 . _:b496050266 . _:b496049294 . . . _:b496049557 . _:b496049946 . _:b496049271 . . . _:b496050085 . _:b496049687 . . _:b496049320 . _:b496049576 . . . . _:b496049177 . _:b496049980 . _:b16663536 "Anchorage-independent growth was measured as previously described>>30<<. Annexin V analysis was performed using the FITC Annexin Apoptosis Detection Kit (BD Pharmingen), on S7KD and control U2OS cells cultured in 1% serum." . . _:b496049699 . _:b496049900 . _:b496049649 . . _:b496050075 . . . . . . _:b496050020 . . _:b496050245 . . _:b496049943 . . _:b496049341 . . . . _:b496049802 . _:b496049253 . _:b496050307 . _:b496050271 . _:b496049881 . _:b496049526 . _:b496049720 . _:b496049725 . . _:b496049344 . . _:b496050153 . . . . . . . _:b496049290 . _:b496049751 . _:b496049356 . _:b496050041 . . _:b496049718 . . . _:b496049753 . . . _:b16663554 . _:b496049713 . . . . _:b496049617 . . . . _:b496050351 . . _:b496050337 . . . . . _:b496049401 . . _:b496049936 . . _:b16663552 "The position weight matrix of the ELK4 motif (Supplementary Table 6) was remapped to the identified SIRT7 peaks using cisgenome>>34<<, with parameter \u201C\u2013r 30\u201D." . . . . . _:b496049958 . . _:b496049811 . . _:b496050338 . _:b496049976 . _:b496049358 . . _:b496050047 . . . . _:b496049953 . _:b496050202 . . . _:b496050064 . _:b496049255 . . _:b496050234 . . . _:b496049171 . . _:b16663551 "The top 50 detected de novo motifs (top 5 of each motif size) were recorded and compared with JASPAR motif database using STAMP with default settings>>42<<. The position weight matrix of the ELK4 motif (Supplementary Table 6) was remapped to the identified SIRT7 peaks using cisgenome34, with parameter \u201C\u2013r 30\u201D." . . _:b496049148 . . _:b496049170 . . _:b496049523 . _:b496050317 . . _:b496050324 . _:b496049500 . _:b496050259 . _:b496049150 . . _:b496049839 . . . . _:b496049862 . . . _:b496049681 . _:b496049787 . _:b496049738 . _:b496049606 . _:b496049308 . _:b496049673 . _:b496049815 . . _:b496050067 . _:b496049715 . _:b496049996 . . . _:b496049488 . _:b496049329 . _:b496050156 . . _:b496050163 . _:b496049684 . . . . . . _:b496049270 . _:b496050006 . . . _:b16663549 . . _:b496049594 . . _:b496050404 . . _:b496049209 . . . . . . . _:b496049782 . . _:b496049872 . _:b496049323 . . _:b496049307 . _:b496049959 . _:b496049838 . . _:b496050092 . _:b496049765 . . . . _:b496049161 . . _:b496050316 . _:b496049730 . _:b496049593 . . . _:b496049478 . _:b496049974 . . _:b496050058 . _:b496050381 . _:b496050157 . . _:b496049873 . _:b496049536 . _:b496050048 . . . . . _:b496050050 . _:b496049832 . . _:b496049619 . . _:b496050013 . _:b496049463 . . . . _:b496049443 . . . _:b496049659 . _:b496049368 . . _:b496049867 . _:b496049477 . _:b496049296 . _:b496049618 . . _:b496049211 . . . _:b496049940 . _:b496049880 . . . . _:b496049259 . _:b496050319 . . _:b496050305 . _:b496049749 . _:b496049949 . . _:b496050089 . _:b496050298 . . _:b496050299 . _:b496049742 . _:b496050244 . _:b496050101 . _:b496049497 . . _:b496050261 . _:b496049890 . _:b496049818 . _:b496049608 . _:b496050155 . _:b16663543 "Equal amounts of both samples as quantified earlier by a Bradford assay were mixed together, and digested peptides were desalted using homemade STAGE tips as reported earlier>>36<<. Desalted peptides were loaded onto fused silica microcapillary column (75 \u00B5m) packed with C18 resin constructed with an ESI tip through an Eksigent AS-2 autosampler (Eksigent Technologies Inc., Dublin, CA) at a rate of ~200 nL/minute." . . . . _:b496050000 . . _:b496049801 . _:b496049833 . . . . . . _:b496049207 . _:b16663534 _:b16663552 . _:b16663534 _:b16663553 . . . _:b496049185 . . _:b496049770 . . . . _:b496049903 . _:b496050357 . . . . _:b496049469 . _:b496049768 . _:b496049288 . _:b496049474 . _:b496050070 . . . _:b496049885 . . . . _:b496050065 . _:b496049611 . _:b496050126 . _:b496049406 . . . . _:b496049336 . _:b496050054 . . . _:b496049407 . _:b496049665 . _:b496049800 . _:b496049604 . _:b496049337 . _:b496049817 . _:b496049287 . _:b496050248 . . . _:b496049798 . _:b496050112 . _:b496049855 . _:b496049743 . _:b496050146 . . _:b496050407 . . . _:b496050393 . _:b496049628 . _:b496050080 . _:b496050088 . _:b496050149 . _:b496050120 . _:b496049686 . . . . . . _:b496049819 . . _:b496049231 . _:b496049664 . _:b496049454 . _:b496049166 . . . _:b496049911 . _:b496049382 . _:b496049639 . . _:b496049847 . . . _:b496050125 . . _:b496049869 . . _:b496049395 . _:b496049599 . . . _:b496049778 . _:b496050394 . _:b496049492 . _:b496049857 . . _:b496049780 . _:b496049571 . . . . _:b16663548 . . _:b496049860 . _:b496049286 . . _:b496050159 . _:b496049411 . _:b16663546 . _:b496049567 . . . . _:b496050004 . _:b496049352 . . _:b496050181 "2"^^ . . _:b496049521 . _:b496050180 "2"^^ . . _:b16663542 . . _:b496050183 "2"^^ . _:b496050182 "2"^^ . _:b496050177 "2"^^ . _:b496050104 . _:b496050176 "2"^^ . _:b496050179 "2"^^ . _:b496050148 . . _:b496050178 "2"^^ . _:b496049256 . _:b496050189 "2"^^ . _:b496050188 "2"^^ . . _:b496050191 "2"^^ . _:b496050285 . _:b496050190 "2"^^ . . _:b496050175 . _:b496050185 "2"^^ . . _:b496049436 . _:b496050184 "2"^^ . . . _:b496050187 "2"^^ . . _:b496050186 "2"^^ . _:b496050197 "2"^^ . _:b496050196 "2"^^ . . _:b496050199 "2"^^ . _:b496050198 "2"^^ . . _:b496049453 . _:b496050193 "2"^^ . . . _:b496050192 "2"^^ . . _:b496050195 "2"^^ . _:b496050194 "2"^^ . _:b496049541 . _:b496050205 "2"^^ . _:b496050399 . _:b496050204 "2"^^ . _:b496049589 . _:b496050207 "2"^^ . . _:b496050206 "2"^^ . _:b496050201 "2"^^ . _:b496050200 "2"^^ . . _:b496050203 "2"^^ . _:b496049547 . _:b496050202 "2"^^ . _:b496049568 . _:b496050213 "2"^^ . _:b496049491 . _:b496050212 "2"^^ . . _:b496050072 . _:b496050215 "2"^^ . _:b496049933 . . _:b496050214 "2"^^ . _:b16663541 . . _:b496050209 "2"^^ . _:b496049689 . _:b496050275 . _:b496050208 "2"^^ . _:b496049582 . . _:b496050211 "2"^^ . _:b496049489 . . _:b496050210 "2"^^ . _:b496050221 "2"^^ . . _:b496050220 "2"^^ . . . _:b496049920 . _:b496050223 "2"^^ . _:b496049841 . . _:b496050222 "2"^^ . _:b496050332 . _:b496050217 "2"^^ . . . _:b496050216 "2"^^ . _:b496049164 . _:b496050219 "2"^^ . _:b496050218 "2"^^ . . _:b496050229 "2"^^ . _:b496050118 . _:b496050228 "2"^^ . _:b496050231 "2"^^ . _:b496050230 "2"^^ . _:b496049384 . _:b496049682 . _:b496050316 . _:b496050225 "2"^^ . _:b496050317 . . _:b496050318 . _:b496050319 . _:b496050312 . _:b496050224 "2"^^ . _:b496050233 . _:b496050313 . _:b496049712 . _:b496050314 . _:b496050315 . _:b496050308 . _:b496050227 "2"^^ . _:b496050309 . _:b496049931 . _:b496050310 . _:b496050311 . . _:b496050304 . _:b496050226 "2"^^ . _:b496050305 . _:b496050306 . _:b496050307 . _:b496050327 . _:b496050332 . _:b496050237 "2"^^ . . _:b496050333 . _:b496050334 . _:b496050335 . _:b496050328 . _:b496050236 "2"^^ . . _:b496050329 . _:b496050330 . _:b496050331 . _:b496050324 . _:b496050239 "2"^^ . _:b496050325 . _:b496050326 . _:b496050166 . . _:b496050327 . _:b496050320 . _:b496050238 "2"^^ . _:b496050321 . _:b496050322 . . _:b496050323 . _:b496050348 . _:b496050233 "2"^^ . _:b496050349 . _:b496050350 . _:b496050113 . _:b496050351 . _:b496050344 . _:b496050232 "2"^^ . _:b496050345 . _:b496050346 . _:b496050347 . _:b496050340 . _:b496050235 "2"^^ . _:b496049859 . _:b496050341 . _:b496050342 . _:b496050343 . _:b496050336 . _:b496050234 "2"^^ . _:b496050337 . _:b496050338 . _:b496050339 . _:b496050364 . _:b496050245 "2"^^ . _:b496050365 . _:b496050366 . _:b496049175 . _:b496049422 . _:b496050367 . _:b496050360 . _:b496050244 "2"^^ . _:b496050361 . _:b496050362 . _:b496050363 . _:b496049919 . _:b496050356 . _:b496050247 "2"^^ . _:b496050357 . _:b496050358 . _:b496050359 . _:b496049504 . _:b496050134 . _:b496050352 . _:b496049375 . _:b496050246 "2"^^ . _:b496050353 . _:b496050354 . _:b496050355 . _:b496050322 . _:b496050380 . _:b496050241 "2"^^ . _:b496050381 . _:b496050382 . _:b496050383 . _:b496050376 . _:b496050240 "2"^^ . _:b496050377 . _:b496050378 . _:b496050379 . _:b496050372 . _:b496050243 "2"^^ . _:b496050373 . _:b496050374 . _:b496050375 . _:b496050368 . _:b496050242 "2"^^ . _:b496050369 . _:b496050370 . _:b496050371 . . _:b496050396 . _:b496050253 "2"^^ . _:b496050397 . _:b496050398 . . _:b496050399 . _:b496050392 . _:b496050252 "2"^^ . _:b496050393 . _:b496050394 . _:b496050395 . _:b496050388 . _:b496050255 "2"^^ . _:b496050389 . . _:b496050390 . _:b496050391 . . _:b496050384 . _:b496050254 "2"^^ . _:b496050385 . _:b496049240 . _:b496050386 . _:b496050387 . _:b496050249 "2"^^ . _:b496050408 . _:b496050248 "2"^^ . _:b496049225 . _:b496050318 . _:b496050404 . _:b496050251 "2"^^ . _:b496050405 . _:b496050406 . _:b496050407 . _:b496049351 . _:b496050400 . _:b496050250 "2"^^ . _:b496050401 . _:b496050402 . _:b496050403 . _:b496050261 "2"^^ . _:b496050260 "2"^^ . _:b496049662 . _:b496050263 "2"^^ . . . _:b496050262 "2"^^ . . _:b496049482 . _:b496050188 . _:b496050257 "2"^^ . _:b496050189 . _:b496050190 . _:b496050191 . _:b496050184 . _:b496050256 "2"^^ . _:b496050185 . _:b496050186 . _:b496050187 . _:b496050180 . _:b496050259 "2"^^ . _:b496050181 . _:b496050182 . _:b496050183 . _:b496050176 . _:b496050258 "2"^^ . _:b496050177 . _:b496049520 . _:b496050178 . _:b496050179 . . _:b496050204 . _:b496050269 "2"^^ . _:b496050205 . . _:b496050206 . _:b496050207 . _:b496050200 . _:b496050268 "2"^^ . _:b496050201 . _:b496050202 . _:b496050362 . _:b496050203 . _:b496049448 . _:b496050196 . _:b496050271 "2"^^ . _:b496050197 . _:b496050198 . _:b496050199 . _:b496050192 . _:b496050270 "2"^^ . _:b496050193 . _:b496050194 . _:b496049360 . _:b496050195 . _:b496049979 . _:b496050220 . _:b496050265 "2"^^ . _:b496050221 . _:b496050222 . _:b496050223 . . _:b496050216 . _:b496050339 . _:b496050264 "2"^^ . _:b496050217 . _:b496050218 . _:b496050219 . _:b496050212 . _:b496050267 "2"^^ . . _:b496050213 . _:b496050214 . _:b496050215 . . _:b496050266 "2"^^ . _:b496050208 . _:b496050209 . _:b496050210 . _:b496050211 . _:b496050236 . _:b496050302 . _:b496050277 "2"^^ . . _:b496050237 . . _:b496050238 . _:b496049678 . _:b496050239 . _:b496049990 . _:b496050232 . _:b496050276 "2"^^ . _:b496050233 . . _:b496050234 . . _:b496050235 . _:b496050228 . _:b496050279 "2"^^ . . _:b496050229 . _:b496050230 . _:b496050231 . _:b496050224 . _:b496050278 "2"^^ . _:b496049509 . _:b496050225 . _:b496050226 . . _:b496050227 . _:b496050252 . _:b496050273 "2"^^ . . _:b496050253 . _:b496050254 . _:b496050255 . _:b496050248 . _:b496050272 "2"^^ . _:b496050249 . _:b496050250 . _:b496050251 . _:b496050244 . _:b496050275 "2"^^ . _:b496050245 . _:b496050246 . _:b496050247 . _:b496050240 . _:b496050274 "2"^^ . _:b496050241 . _:b496050242 . _:b496050138 . _:b496050243 . _:b496050268 . _:b496050285 "2"^^ . _:b496050269 . _:b496049808 . _:b496050270 . . . _:b496050271 . _:b496050264 . _:b496050284 "2"^^ . . _:b496050265 . _:b496050266 . _:b496050267 . _:b496050260 . _:b496050287 "2"^^ . _:b496050261 . _:b496050262 . _:b496050263 . _:b496050256 . _:b496050286 "2"^^ . _:b496050257 . _:b496050258 . _:b496050117 . _:b496050259 . . _:b496050281 "2"^^ . _:b496050284 . _:b496050285 . _:b496050286 . _:b496050287 . _:b496050280 . _:b496050280 "2"^^ . . _:b496050281 . _:b496050282 . _:b496050283 . . _:b496050283 "2"^^ . . _:b496050276 . _:b496050277 . _:b496050278 . _:b496050279 . _:b496049195 . _:b496050282 "2"^^ . _:b496050272 . _:b496050273 . _:b496050274 . _:b496050275 . _:b496050300 . _:b496050293 "2"^^ . _:b496050301 . _:b496050302 . _:b496050303 . _:b496049677 . _:b496050296 . _:b496050292 "2"^^ . _:b496050297 . . _:b496050298 . _:b496050299 . . _:b496050295 "2"^^ . _:b496050292 . . _:b496050293 . _:b496050294 . _:b496050295 . _:b496050288 . _:b496050294 "2"^^ . _:b496050289 . . _:b496050290 . _:b496050291 . _:b496050289 "2"^^ . _:b496050288 "2"^^ . _:b496049345 . _:b496050291 "2"^^ . . _:b496050290 "2"^^ . _:b496050301 "2"^^ . . _:b496050300 "2"^^ . . _:b496050303 "2"^^ . _:b496050302 "2"^^ . _:b496049316 . _:b496050297 "2"^^ . _:b496050296 "2"^^ . . . _:b496050299 "2"^^ . _:b496049361 . _:b496050298 "2"^^ . _:b496049283 . . _:b496050309 "2"^^ . _:b496049176 . _:b496050308 "2"^^ . _:b496050311 "2"^^ . _:b496050197 . . _:b496050310 "2"^^ . . _:b496049888 . _:b496050305 "2"^^ . _:b496050304 "2"^^ . . _:b496050196 . _:b496050307 "2"^^ . _:b496050129 . _:b496050306 "2"^^ . . . _:b496050317 "2"^^ . _:b496050316 "2"^^ . _:b496049887 . _:b496050211 . _:b496050319 "2"^^ . . . _:b496050318 "2"^^ . _:b496050313 "2"^^ . . _:b496050312 "2"^^ . _:b496049220 . _:b496050315 "2"^^ . _:b496050376 . . _:b496050314 "2"^^ . _:b496050325 "2"^^ . . _:b496049741 . _:b496050324 "2"^^ . . _:b496050327 "2"^^ . . _:b496050326 "2"^^ . _:b496050321 "2"^^ . _:b496050198 . _:b496050182 . _:b496050397 . _:b496050320 "2"^^ . _:b496050323 "2"^^ . _:b496050353 . _:b496050322 "2"^^ . _:b496050110 . _:b496050333 "2"^^ . . . _:b496050332 "2"^^ . . . _:b496050335 "2"^^ . _:b496049735 . _:b496050334 "2"^^ . . . . _:b496049485 . . _:b496050329 "2"^^ . . . _:b496050328 "2"^^ . _:b496050331 "2"^^ . _:b496050223 . _:b496050330 "2"^^ . . _:b496050341 "2"^^ . _:b496050340 "2"^^ . . . _:b496050343 "2"^^ . _:b496049555 . . _:b496049299 . _:b496050342 "2"^^ . . _:b496050337 "2"^^ . _:b496050336 "2"^^ . _:b496049577 . _:b496050249 . _:b496050339 "2"^^ . _:b496050338 "2"^^ . _:b496050074 . . _:b496050349 "2"^^ . _:b496050348 "2"^^ . _:b496050351 "2"^^ . . . _:b496050350 "2"^^ . . _:b496050164 . _:b496049399 . _:b496050345 "2"^^ . _:b496050201 . _:b496049513 . _:b496050344 "2"^^ . . _:b496050347 "2"^^ . . . _:b496050292 . _:b496050346 "2"^^ . . _:b496049423 . _:b496050357 "2"^^ . _:b496050052 . . _:b496050356 "2"^^ . _:b496050359 "2"^^ . _:b496050358 "2"^^ . _:b496049624 . _:b496049151 . _:b496050353 "2"^^ . _:b496050352 "2"^^ . . _:b496049625 . _:b496050355 "2"^^ . _:b496050354 "2"^^ . _:b496050365 "2"^^ . _:b496049661 . _:b496050364 "2"^^ . _:b496050368 . _:b496050367 "2"^^ . _:b496050366 "2"^^ . . . _:b496050361 "2"^^ . _:b496050360 "2"^^ . _:b496050363 "2"^^ . . . _:b496050362 "2"^^ . _:b496050373 "2"^^ . _:b496050210 . . _:b496050372 "2"^^ . _:b496050375 "2"^^ . _:b496050374 "2"^^ . _:b496049398 . _:b496050007 . _:b496050369 "2"^^ . _:b496050239 . _:b496050300 . . _:b496050368 "2"^^ . . _:b496050371 "2"^^ . _:b496049615 . _:b496050370 "2"^^ . _:b496050381 "2"^^ . _:b496049846 . _:b496049339 . _:b496050380 "2"^^ . _:b496049202 . _:b496050383 "2"^^ . _:b496049412 . _:b496050382 "2"^^ . . _:b496050377 "2"^^ . _:b496050376 "2"^^ . _:b496050310 . _:b496050379 "2"^^ . _:b496050378 "2"^^ . _:b496050389 "2"^^ . _:b496050306 . . _:b496050029 . _:b496050388 "2"^^ . _:b496050391 "2"^^ . _:b496050390 "2"^^ . _:b496050385 "2"^^ . _:b496050384 "2"^^ . . _:b496050387 "2"^^ . _:b496049532 . _:b496050386 "2"^^ . . _:b496050397 "2"^^ . _:b496050396 "2"^^ . _:b496049671 . . _:b496050399 "2"^^ . . . _:b496050398 "2"^^ . _:b496050393 "2"^^ . _:b496050016 . _:b496049569 . _:b496050392 "2"^^ . . _:b496050395 "2"^^ . _:b496050394 "2"^^ . _:b496049828 . _:b496050405 "2"^^ . _:b496050404 "2"^^ . . _:b496050407 "2"^^ . . _:b16663534 _:b16663548 . _:b16663534 _:b16663549 . _:b16663534 _:b16663550 . _:b16663534 _:b16663551 . _:b496050406 "2"^^ . _:b16663534 _:b16663544 . _:b496049791 . _:b16663534 _:b16663545 . . _:b16663534 _:b16663546 . _:b16663534 _:b16663547 . _:b496050401 "2"^^ . . _:b16663534 _:b16663540 . . _:b16663534 _:b16663541 . _:b16663534 _:b16663542 . _:b16663534 _:b16663543 . _:b496050400 "2"^^ . _:b16663534 _:b16663536 . _:b16663534 _:b16663537 . _:b16663534 _:b16663538 . _:b16663534 _:b16663539 . _:b496050403 "2"^^ . _:b16663534 _:b16663535 . _:b496050402 "2"^^ . . . _:b496049981 . _:b496050408 "2"^^ . . _:b496049198 . _:b496050056 . _:b496050177 . _:b496049178 . _:b496049592 . _:b496049957 . . _:b496050356 . _:b496050391 . . _:b496050333 . _:b496049515 . . _:b496049748 . . . . _:b496050262 . _:b16663545 "The uniquely mapped reads from replicates of SIRT7 and input control samples were pooled respectively and processed by MACS (version 1.3.6)>>38<< to generate the whole-genome ChIP-sequencing profiles, with the \u201C--diag\u201D option enabled for the sequencing depth saturation test." . . _:b496049396 . . . . . _:b496049388 . _:b496050377 . _:b496050122 . _:b496049562 . . . _:b496049983 . . . . . . . . _:b496050232 . . _:b496049670 . _:b496049648 . _:b496050090 . _:b496049840 . . _:b496050395 . _:b496050081 . _:b16663545 . _:b16663540 . . . _:b496050061 . . . _:b496049427 . . _:b496049723 . . . _:b496049394 . _:b496049516 . _:b496050208 . _:b496050107 . _:b496050010 . . . . . . . . _:b496049450 . . _:b16663537 "Samples enriched for cytoplasmic, nucleoplasmic, and chromatin fractions were prepared as previously described>>31<<. Co-immunoprecipitations were performed as previously described32, except that one 150 mm plate of cells was used per IP, Protein A/G beads (Sigma) were used instead of FLAG-resin, and elution was performed by boiling beads in Laemmli" . _:b496049614 . _:b496049332 . . . _:b496049479 . _:b496049473 . _:b496049991 . . _:b496050240 . . . . _:b496049825 . . . _:b496050203 . _:b496049261 . _:b496049188 . . . _:b496050328 . . _:b496049321 . . . _:b16663553 . . . . . . _:b16663556 . _:b496049579 . . . _:b496049305 . _:b496050281 . _:b496049669 "3"^^ . _:b496049668 "3"^^ . . _:b496050009 . _:b496049671 "3"^^ . . _:b496049670 "3"^^ . _:b496049674 . . _:b496049665 "3"^^ . . _:b496049664 "3"^^ . _:b496049434 . _:b496050304 . _:b496049667 "3"^^ . . . . _:b496049666 "3"^^ . _:b496049432 . . _:b496050093 . . _:b496049677 "3"^^ . _:b496049676 "3"^^ . _:b496049679 "3"^^ . . _:b496049678 "3"^^ . _:b496049616 . . _:b496049673 "3"^^ . _:b496049672 "3"^^ . _:b496049498 . . _:b496049675 "3"^^ . . _:b496049674 "3"^^ . _:b16663539 "Purification of human SIRT7 protein from baculovirus-infected insect cells was described previously>>8<<. Calf thymus histones were obtained from Roche, and poly-nucleosomes were purified from HeLa cells as previously described33. Histone peptides were synthesized at the Yale W. M. Keck peptide synthesis facility, and liquid chromatography" . _:b496049685 "3"^^ . _:b496049684 "3"^^ . _:b496050242 . _:b496049687 "3"^^ . . . _:b496049686 "3"^^ . . _:b496049681 "3"^^ . . _:b496049680 "3"^^ . _:b496049683 "3"^^ . _:b496049338 . _:b496049682 "3"^^ . _:b496049693 "3"^^ . . _:b496049692 "3"^^ . _:b496049695 "3"^^ . _:b496049694 "3"^^ . _:b496049834 . _:b496049689 "3"^^ . _:b496049688 "3"^^ . _:b496049414 . _:b496049861 . _:b496049691 "3"^^ . . _:b496049690 "3"^^ . _:b496049350 . _:b496049575 . _:b496049701 "3"^^ . _:b496049333 . _:b496049700 "3"^^ . . _:b496050221 . _:b496049703 "3"^^ . _:b496049556 . _:b496050326 . _:b496049702 "3"^^ . . . _:b496049697 "3"^^ . . _:b496049696 "3"^^ . _:b496049699 "3"^^ . _:b496049698 "3"^^ . _:b496049709 "3"^^ . . _:b496049708 "3"^^ . . _:b496049711 "3"^^ . . _:b496049710 "3"^^ . . _:b496049705 "3"^^ . _:b496049704 "3"^^ . _:b496049707 "3"^^ . _:b496049706 "3"^^ . _:b496050145 . _:b496049717 "3"^^ . _:b496049752 . . . _:b496049716 "3"^^ . . _:b496049719 "3"^^ . _:b496049718 "3"^^ . _:b496049713 "3"^^ . . _:b496049712 "3"^^ . _:b496049715 "3"^^ . _:b496049714 "3"^^ . _:b496049725 "2"^^ . . _:b496049724 "2"^^ . _:b496049948 . _:b496049874 . _:b496049727 "2"^^ . _:b496050173 . _:b496049726 "2"^^ . _:b496050002 . _:b496049721 "3"^^ . . _:b496049720 "3"^^ . _:b496049525 . _:b496049723 "2"^^ . _:b16663544 . _:b496049722 "3"^^ . _:b496049733 "2"^^ . _:b496049732 "2"^^ . . _:b496049735 "2"^^ . . _:b496049734 "2"^^ . _:b496050268 . _:b496049997 . _:b496049876 . _:b496049729 "2"^^ . . . _:b496049728 "2"^^ . . _:b496049731 "2"^^ . . _:b496049730 "2"^^ . . . _:b496049232 . _:b496049741 "2"^^ . _:b496049551 . _:b496049517 . . _:b496049854 . . _:b496049740 "2"^^ . . _:b496049743 "2"^^ . _:b496049742 "2"^^ . _:b496049514 . _:b496049737 "2"^^ . _:b496050256 . _:b496049736 "2"^^ . . _:b16663553 "Cells were prepared for ChIP as previously described>>29<<, with the exception that DNA was washed and eluted using a PCR purification kit (Qiagen) rather than by phenol-chloroform extraction." . _:b496049612 . _:b496049739 "2"^^ . _:b496049738 "2"^^ . _:b496049749 "2"^^ . _:b496049748 "2"^^ . _:b496049820 . _:b496049751 "2"^^ . _:b496049750 "2"^^ . . . . _:b496049745 "2"^^ . _:b496049744 "2"^^ . _:b496049747 "2"^^ . _:b496049746 "2"^^ . _:b496049194 . . _:b496049757 "2"^^ . _:b496049756 "2"^^ . . _:b496049759 "2"^^ . _:b496049758 "2"^^ . _:b496049826 . _:b496049753 "2"^^ . _:b496049752 "2"^^ . _:b496049755 "2"^^ . _:b496049884 . _:b496049754 "2"^^ . _:b496049765 "2"^^ . _:b496050001 . . _:b496049561 . _:b496049764 "2"^^ . _:b496049767 "2"^^ . . _:b496049766 "2"^^ . _:b496049761 "2"^^ . _:b496049760 "2"^^ . . _:b496050119 . _:b496049763 "2"^^ . _:b496049696 . . . _:b496049762 "2"^^ . _:b496050035 . . _:b496049773 "2"^^ . _:b16663555 . _:b496049772 "2"^^ . _:b496050207 . _:b496049775 "2"^^ . . . _:b496049774 "2"^^ . _:b496049769 "2"^^ . . _:b496049768 "2"^^ . . _:b496049771 "2"^^ . . _:b496049770 "2"^^ . . _:b496049781 "2"^^ . _:b496049780 "2"^^ . _:b496049783 "2"^^ . _:b496049390 . _:b496049877 . . . _:b496049782 "2"^^ . . . _:b496049777 "2"^^ . . . . _:b496049776 "2"^^ . _:b496049779 "2"^^ . . _:b496049778 "2"^^ . _:b496049955 . _:b496049335 . _:b496049789 "2"^^ . _:b16663539 . _:b496049558 . _:b496049788 "2"^^ . . _:b496049563 . _:b496049791 "2"^^ . _:b496049709 . . _:b496049790 "2"^^ . _:b496049785 "2"^^ . _:b496049784 "2"^^ . _:b496049460 . _:b496049787 "2"^^ . _:b496049786 "2"^^ . _:b496049797 "2"^^ . _:b496049796 "2"^^ . _:b496050063 . _:b496049799 "2"^^ . . . . _:b496049798 "2"^^ . . _:b496049173 . . _:b496049793 "2"^^ . . _:b496049792 "2"^^ . . _:b496049843 . _:b496049795 "2"^^ . _:b496049772 . _:b496049794 "2"^^ . _:b496049805 "2"^^ . . _:b496050284 . _:b496049804 "2"^^ . . _:b496049705 . _:b496049807 "2"^^ . _:b496049215 . _:b496049806 "2"^^ . _:b496049801 "2"^^ . _:b496049580 . _:b496049800 "2"^^ . _:b496049803 "2"^^ . . _:b496049802 "2"^^ . _:b16663556 . _:b496049813 "2"^^ . _:b496049812 "2"^^ . _:b496050218 . _:b496049815 "2"^^ . _:b496049814 "2"^^ . _:b496049250 . _:b16663552 . _:b496049809 "2"^^ . _:b16663553 . _:b496050312 . _:b496049808 "2"^^ . _:b16663554 . _:b496049233 . _:b496049914 . _:b496049811 "2"^^ . _:b16663555 . _:b496049810 "2"^^ . _:b496049799 . _:b496049821 "2"^^ . _:b496049820 "2"^^ . _:b496049823 "2"^^ . _:b496049822 "2"^^ . . _:b496049636 . _:b496049817 "2"^^ . . _:b496049816 "2"^^ . _:b496050184 . _:b496049391 . _:b496049466 . _:b496049819 "2"^^ . _:b496049703 . _:b496049818 "2"^^ . _:b496049937 . _:b496049829 "2"^^ . _:b496049828 "2"^^ . . . _:b496049831 "2"^^ . . _:b496049830 "2"^^ . _:b496049635 . _:b496049825 "2"^^ . _:b496049824 "2"^^ . . . _:b496049827 "2"^^ . _:b496049826 "2"^^ . _:b496049837 "2"^^ . _:b496049836 "2"^^ . _:b496050258 . _:b496049298 . . _:b496049839 "2"^^ . _:b496049838 "2"^^ . _:b496049833 "2"^^ . _:b496049832 "2"^^ . _:b496049756 . _:b496049835 "2"^^ . _:b496049834 "2"^^ . . . . _:b496049845 "2"^^ . _:b496049844 "2"^^ . _:b496049847 "2"^^ . . _:b496049846 "2"^^ . _:b496049459 . . _:b496049841 "2"^^ . _:b496049840 "2"^^ . . _:b496049843 "2"^^ . _:b496050062 . _:b496049842 "2"^^ . _:b496049853 "2"^^ . . _:b496050023 . _:b496049852 "2"^^ . _:b496049855 "2"^^ . _:b496049854 "2"^^ . _:b496049313 . . _:b496049849 "2"^^ . _:b496049262 . _:b496050231 . _:b496049848 "2"^^ . _:b496049511 . _:b496049851 "2"^^ . _:b496049850 "2"^^ . _:b496049861 "2"^^ . . _:b496049860 "2"^^ . _:b496049863 "2"^^ . _:b496049602 . _:b496049862 "2"^^ . _:b496049857 "2"^^ . . _:b496049856 "2"^^ . _:b496049859 "2"^^ . . _:b496049858 "2"^^ . _:b496049869 "2"^^ . _:b496049163 . _:b496049868 "2"^^ . . _:b496049871 "2"^^ . _:b496049455 . _:b496049304 . _:b496049870 "2"^^ . . _:b496049865 "2"^^ . _:b496049864 "2"^^ . _:b496050321 . _:b496050024 . _:b496049745 . _:b496049867 "2"^^ . _:b496049866 "2"^^ . . . _:b496049877 "2"^^ . . _:b496049876 "2"^^ . . . _:b496049879 "2"^^ . . _:b496049369 . _:b496049878 "2"^^ . _:b496049873 "2"^^ . . . _:b496049872 "2"^^ . . _:b496049875 "2"^^ . _:b496049638 . . . _:b496049874 "2"^^ . _:b496049885 "2"^^ . . . . _:b496049884 "2"^^ . _:b496049887 "2"^^ . . _:b496049886 "2"^^ . . _:b496049881 "2"^^ . _:b496050051 . _:b496049379 . _:b496049880 "2"^^ . _:b496049883 "2"^^ . _:b496049882 "2"^^ . _:b496049964 . . _:b496049364 . _:b496049893 "2"^^ . _:b496049892 "2"^^ . _:b496049264 . _:b496049895 "2"^^ . _:b496049196 . . _:b496049894 "2"^^ . _:b496050295 . _:b496049889 "2"^^ . . _:b496049888 "2"^^ . _:b496049891 "2"^^ . _:b496049508 . _:b496049890 "2"^^ . . _:b496049901 "2"^^ . _:b496049900 "2"^^ . _:b496050167 . . _:b496049442 . _:b496049903 "2"^^ . _:b496049902 "2"^^ . _:b496049897 "2"^^ . . _:b496049896 "2"^^ . _:b496049282 . _:b496049899 "2"^^ . . _:b496050297 . _:b496049898 "2"^^ . _:b496049909 "2"^^ . _:b496049908 "2"^^ . _:b496049911 "2"^^ . . _:b496049910 "2"^^ . _:b496050044 . _:b496050373 . _:b496049905 "2"^^ . . . _:b496049904 "2"^^ . . _:b496049419 . . _:b496049907 "2"^^ . . _:b496049906 "2"^^ . _:b496049522 . _:b496049917 "2"^^ . _:b496049916 "2"^^ . _:b496049919 "2"^^ . _:b496049918 "2"^^ . . _:b496050263 . . _:b496049913 "2"^^ . _:b496049912 "2"^^ . . . _:b496050225 . _:b496049915 "2"^^ . . _:b496049914 "2"^^ . _:b496049970 . _:b496049925 "2"^^ . _:b496049435 . _:b496049924 "2"^^ . . . _:b496049927 "2"^^ . . . _:b496049977 . _:b496050237 . _:b496049926 "2"^^ . . _:b496049921 "2"^^ . _:b496049376 . _:b496049920 "2"^^ . _:b496049923 "2"^^ . _:b496049922 "2"^^ . . _:b496049933 "2"^^ . _:b496049932 "2"^^ . . _:b496049935 "2"^^ . _:b496049934 "2"^^ . _:b16663556 "ChIP was performed as previously described>>29<<, except that the Qiagen PCR purification kit was used for DNA purification (Qiagen)." . . _:b496049929 "2"^^ . _:b496049456 . _:b496049928 "2"^^ . . _:b496049931 "2"^^ . _:b496049930 "2"^^ . _:b496049941 "2"^^ . _:b496049806 . _:b496049940 "2"^^ . . . _:b496049943 "2"^^ . _:b496049942 "2"^^ . . _:b496049937 "2"^^ . . _:b496049936 "2"^^ . _:b496049310 . . _:b496049939 "2"^^ . _:b496049938 "2"^^ . _:b496049476 . _:b496049949 "2"^^ . _:b496049357 . _:b496049948 "2"^^ . . _:b496049951 "2"^^ . . _:b496050003 . _:b496049950 "2"^^ . _:b496050367 . . _:b496049945 "2"^^ . . _:b496049944 "2"^^ . _:b496049490 . _:b496049947 "2"^^ . . _:b496050345 . _:b496049946 "2"^^ . _:b496049902 . . _:b496049957 "2"^^ . _:b496049956 "2"^^ . _:b496049385 . _:b496049651 . _:b496049959 "2"^^ . _:b496049958 "2"^^ . _:b16663544 "ChIP for ChIP-sequencing analysis was performed as previously described>>37<<. Four ChIP samples were sequenced using Illumina Solexa Genome Analyzer II single end sequencing protocol, including two SIRT7 replicates and two input control replicates." . . _:b496049953 "2"^^ . _:b496049679 . _:b496049952 "2"^^ . . _:b496049493 . _:b496049955 "2"^^ . . _:b496049954 "2"^^ . . _:b496049965 "2"^^ . _:b496049964 "2"^^ . _:b496049967 "2"^^ . _:b496049966 "2"^^ . _:b496049961 "2"^^ . _:b496050043 . _:b496049960 "2"^^ . _:b496049963 "2"^^ . _:b496049301 . _:b496050106 . . _:b496049258 . _:b496049962 "2"^^ . . . . _:b496049973 "2"^^ . _:b496049972 "2"^^ . _:b496049680 . . _:b496049975 "2"^^ . _:b496049969 . _:b496050335 . _:b496049974 "2"^^ . _:b496049969 "2"^^ . _:b496050132 . _:b16663538 . . _:b496049968 "2"^^ . _:b496049971 "2"^^ . . _:b496049970 "2"^^ . _:b496049319 . _:b496049981 "2"^^ . . _:b496049184 . _:b496049980 "2"^^ . . . _:b496049983 "2"^^ . . . _:b496049982 "2"^^ . _:b496049977 "2"^^ . _:b496049976 "2"^^ . . _:b496049979 "2"^^ . _:b496049633 . . _:b496049978 "2"^^ . _:b496049989 "2"^^ . . . _:b496049988 "2"^^ . _:b496049926 . . _:b496049991 "2"^^ . . _:b496049990 "2"^^ . . . _:b496049985 "2"^^ . . . . . _:b496049984 "2"^^ . . _:b496049987 "2"^^ . . _:b496049986 "2"^^ . . . _:b496049997 "2"^^ . _:b496049996 "2"^^ . _:b496049426 . _:b496049999 "2"^^ . _:b496050220 . _:b496049998 "2"^^ . _:b496049993 "2"^^ . . _:b496050366 . _:b496049992 "2"^^ . _:b496050402 . _:b496049995 "2"^^ . . _:b496050204 . _:b496049994 "2"^^ . . _:b496049330 . _:b496050005 "2"^^ . _:b496049774 . . _:b496050004 "2"^^ . _:b496050007 "2"^^ . _:b496050006 "2"^^ . _:b496050001 "2"^^ . . . _:b496049960 . _:b496050000 "2"^^ . _:b496050003 "2"^^ . _:b496050084 . _:b496050002 "2"^^ . _:b496050013 "2"^^ . _:b496050172 . _:b496050012 "2"^^ . _:b496049927 . _:b496049160 . _:b496050213 . _:b496050015 "2"^^ . _:b496050014 "2"^^ . _:b496049821 . _:b496050009 "2"^^ . _:b496049512 . . _:b496050008 "2"^^ . _:b496050011 "2"^^ . _:b496050286 . . . . _:b496050010 "2"^^ . _:b496050083 . _:b496050021 "2"^^ . . . _:b496050020 "2"^^ . _:b496050096 . _:b496050325 . . _:b496050023 "2"^^ . _:b496050022 "2"^^ . . _:b496050017 "2"^^ . _:b496050016 "2"^^ . _:b496050019 "2"^^ . _:b16663550 . _:b496049597 . . _:b496050018 "2"^^ . _:b496050029 "2"^^ . _:b496050354 . . _:b496050028 "2"^^ . _:b496050031 . . _:b496050031 "2"^^ . _:b496050030 "2"^^ . _:b496050025 "2"^^ . _:b496050024 "2"^^ . . _:b496050027 "2"^^ . _:b496050154 . _:b496050026 "2"^^ . . _:b496050037 "2"^^ . _:b496050036 "2"^^ . _:b496050039 "2"^^ . . _:b496050038 "2"^^ . . _:b496050033 "2"^^ . . _:b496049378 . _:b496050032 "2"^^ . _:b496049572 . _:b496050035 "2"^^ . _:b496050034 "2"^^ . _:b496049925 . . _:b496050045 "2"^^ . _:b496050219 . _:b496050044 "2"^^ . _:b496050047 "2"^^ . . _:b496050046 "2"^^ . _:b496050041 "2"^^ . _:b496050040 "2"^^ . _:b496050142 . _:b496049559 . _:b496050043 "2"^^ . _:b496050193 . _:b496050042 "2"^^ . . _:b496050053 "2"^^ . _:b496049542 . _:b496050052 "2"^^ . _:b496050055 "2"^^ . _:b496050054 "2"^^ . _:b496050049 "2"^^ . . _:b496050048 "2"^^ . _:b496050051 "2"^^ . . _:b496050050 "2"^^ . . _:b496050061 "2"^^ . _:b496049827 . _:b496050060 "2"^^ . _:b496050063 "2"^^ . . _:b496050062 "2"^^ . . _:b496050057 "2"^^ . . . _:b496050056 "2"^^ . _:b496050059 "2"^^ . _:b496050058 "2"^^ . . _:b496050082 . _:b496050069 "2"^^ . _:b496050068 "2"^^ . _:b496049950 . _:b496049901 . . . _:b496050071 "2"^^ . _:b496050097 . _:b496050070 "2"^^ . _:b496050027 . . . . _:b496050065 "2"^^ . _:b496050064 "2"^^ . _:b496050067 "2"^^ . _:b496049219 . _:b496050066 "2"^^ . . _:b496050077 "2"^^ . _:b496049416 . _:b496049803 . _:b496049630 . . . _:b496050076 "2"^^ . _:b496050079 "2"^^ . _:b496050078 "2"^^ . . _:b496050360 . _:b496050073 "2"^^ . _:b496050072 "2"^^ . . _:b496050075 "2"^^ . . _:b496050074 "2"^^ . _:b496049739 . _:b496050085 "2"^^ . . _:b496050084 "2"^^ . _:b496050087 "2"^^ . . _:b496050086 "2"^^ . _:b496049214 . _:b496050081 "2"^^ . _:b496050080 "2"^^ . _:b496050083 "2"^^ . _:b496050098 . _:b496049925 . . _:b496050082 "2"^^ . _:b496049924 . _:b496050093 "2"^^ . _:b496049302 . _:b496050141 . _:b496049927 . _:b496050092 "2"^^ . _:b496050274 . _:b496049926 . _:b496050095 "2"^^ . . _:b496049543 . _:b496049921 . _:b496050094 "2"^^ . _:b496049920 . _:b496050089 "2"^^ . _:b496049923 . _:b496050088 "2"^^ . _:b496050252 . _:b496049922 . _:b496049961 . _:b496049907 . _:b496050091 "2"^^ . _:b496049590 . . . _:b496049933 . _:b496050090 "2"^^ . . _:b496049574 . _:b496049932 . _:b496050101 "2"^^ . _:b496049793 . . _:b496050408 . _:b496049935 . _:b496050100 "2"^^ . . _:b496049934 . _:b496050103 "2"^^ . . _:b496049929 . _:b496049663 . _:b496050102 "2"^^ . . _:b496049928 . . _:b496050097 "2"^^ . . . _:b496049931 . _:b496050096 "2"^^ . _:b496049930 . _:b496050099 "2"^^ . _:b496049941 . _:b496050098 "2"^^ . . _:b496049940 . _:b496050109 "2"^^ . . _:b496049731 . _:b496049796 . _:b496049943 . _:b496050108 "2"^^ . _:b496050102 . _:b496049942 . _:b496050111 "2"^^ . . _:b496049937 . _:b496050110 "2"^^ . . _:b496049936 . _:b496050105 "2"^^ . _:b496049939 . _:b496050104 "2"^^ . . _:b496049938 . _:b496050107 "2"^^ . . _:b496049949 . _:b496050106 "2"^^ . _:b496049494 . _:b496049948 . _:b496050117 "2"^^ . _:b496049771 . _:b496049951 . _:b496050116 "2"^^ . _:b496049950 . _:b496050119 "2"^^ . _:b496050068 . . _:b496049945 . _:b496050118 "2"^^ . _:b496049998 . . _:b496049944 . _:b496050113 "2"^^ . _:b496049947 . _:b496050112 "2"^^ . . _:b496049946 . _:b496050115 "2"^^ . _:b496049989 . . _:b496049957 . _:b496050114 "2"^^ . _:b496050160 . _:b496049956 . . _:b496050125 "2"^^ . . _:b496049621 . _:b496049959 . _:b496050124 "2"^^ . _:b496049958 . _:b496050127 "2"^^ . _:b496050076 . _:b496049953 . _:b496050126 "2"^^ . _:b496049952 . _:b496050121 "2"^^ . _:b496049303 . _:b496049613 . _:b496049397 . _:b496049955 . _:b496050120 "2"^^ . . . _:b496049954 . _:b496050343 . _:b496050123 "2"^^ . _:b496049965 . _:b496050122 "2"^^ . . _:b496049964 . _:b496050133 "2"^^ . _:b496049605 . _:b496049967 . _:b496050132 "2"^^ . _:b496049966 . _:b496050135 "2"^^ . . . _:b496049961 . _:b496050134 "2"^^ . . _:b496050017 . _:b496049960 . _:b496050386 . _:b496050129 "2"^^ . _:b496049963 . _:b496050128 "2"^^ . . _:b496049962 . _:b496050131 "2"^^ . _:b496049973 . _:b496050130 "2"^^ . _:b496049192 . _:b496049972 . _:b496050141 "2"^^ . _:b496049975 . _:b496050140 "2"^^ . _:b496049974 . _:b496050143 "2"^^ . _:b496049969 . _:b496050142 "2"^^ . _:b496049968 . _:b496050137 "2"^^ . _:b496049971 . _:b496050136 "2"^^ . _:b496049970 . _:b496050139 "2"^^ . . _:b496049549 . _:b496049981 . _:b496050138 "2"^^ . _:b496049598 . _:b496049980 . _:b496050149 "2"^^ . . _:b496049983 . _:b496050148 "2"^^ . _:b496050303 . _:b496049982 . _:b496050151 "2"^^ . _:b496049977 . _:b496049245 . _:b496050150 "2"^^ . _:b496049246 . _:b496049737 . _:b496049976 . _:b496050145 "2"^^ . _:b496050294 . _:b496049979 . _:b496050144 "2"^^ . _:b496049978 . _:b496050147 "2"^^ . . _:b496049989 . _:b496050146 "2"^^ . . _:b496049988 . _:b496050157 "2"^^ . _:b496049239 . . _:b496049991 . _:b496050156 "2"^^ . . . _:b496049990 . _:b496050159 "2"^^ . . _:b496050278 . _:b496049404 . . . _:b496049985 . _:b496050158 "2"^^ . . _:b496049984 . _:b496050153 "2"^^ . . . _:b496049987 . _:b496050152 "2"^^ . _:b496049315 . _:b496049986 . . _:b496050155 "2"^^ . _:b496050269 . "10.1038%2Fnature11043" . _:b496049997 . _:b496050154 "2"^^ . _:b496049996 . _:b496050165 "2"^^ . _:b496050165 . _:b496049842 . _:b496049999 . _:b496050164 "2"^^ . _:b496049998 . _:b496050167 "2"^^ . _:b496049993 . _:b496050166 "2"^^ . _:b496049992 . _:b496050161 "2"^^ . . . _:b496050160 "2"^^ . _:b496049995 . _:b496049994 . _:b496050163 "2"^^ . _:b496049276 . _:b496050309 . _:b496050005 . . _:b496050162 "2"^^ . _:b496050004 . _:b496050195 . _:b496050173 "2"^^ . . _:b496050007 . _:b496050172 "2"^^ . _:b496049804 . _:b496050006 . _:b496050175 "2"^^ . . _:b496049387 . _:b496050001 . _:b496050174 "2"^^ . . _:b496050000 . _:b496050169 "2"^^ . . _:b496050003 . _:b496050168 "2"^^ . _:b496050002 . _:b496050171 "2"^^ . _:b496049162 . _:b496050013 . _:b496050170 "2"^^ . _:b496050012 . _:b496049154 "24"^^ . _:b496049334 . _:b496050015 . _:b496049155 "23"^^ . _:b496050014 . _:b496049355 . . _:b496050009 . _:b496049152 "26"^^ . _:b496049362 . . . _:b496049153 "25"^^ . _:b496050008 . _:b496049158 "22"^^ . _:b496050011 . _:b496050010 . _:b496049156 "23"^^ . _:b496049159 "21"^^ . _:b496050021 . _:b496049157 "22"^^ . _:b496050020 . _:b496049161 "20"^^ . _:b496050406 . _:b496050023 . _:b496049160 "21"^^ . _:b496050022 . _:b496049163 "18"^^ . _:b496050017 . _:b496049237 . . _:b496049162 "19"^^ . _:b496050016 . _:b496049164 "17"^^ . _:b496050019 . _:b496049165 "17"^^ . _:b496050018 . . . _:b496050349 . _:b496049166 "17"^^ . . _:b496050029 . _:b496049167 "17"^^ . _:b496050028 . . _:b496049461 . _:b496049168 "16"^^ . _:b496050031 . . _:b496049169 "16"^^ . . . _:b496050030 . _:b496049170 "16"^^ . _:b496049530 . _:b496050025 . _:b496049171 "16"^^ . _:b496050024 . . _:b496049172 "16"^^ . _:b496050027 . _:b496049173 "16"^^ . . _:b496050026 . _:b496049174 "15"^^ . _:b496050037 . _:b496049175 "15"^^ . . _:b496050036 . _:b496049176 "15"^^ . _:b496050039 . _:b496049177 "15"^^ . . _:b496050038 . _:b496049178 "15"^^ . . _:b496050033 . _:b496049179 "15"^^ . _:b16663550 "De novo motifs with sizes from 6 to 15 nucleotides were searched within SIRT7 binding sites using MDModule>>41<<, with repetitive regions masked and running parameters \u201C-s 100 -t 50\u201D. The top 50 detected de novo motifs (top 5 of each motif size) were recorded and compared with JASPAR motif database using STAMP with default settings42." . . _:b496049468 . _:b496050032 . . _:b496049180 "14"^^ . _:b16663535 . _:b496050035 . _:b496049181 "14"^^ . _:b496050034 . _:b496049182 "14"^^ . _:b496050045 . _:b496049183 "14"^^ . _:b496050401 . . _:b496050044 . _:b496049184 "14"^^ . _:b496049191 "13"^^ . _:b496050047 . . _:b496049185 "14"^^ . _:b496049190 "13"^^ . _:b496050046 . _:b496049238 . _:b496049186 "14"^^ . . _:b496050217 . _:b496049189 "13"^^ . _:b496050041 . _:b496049814 . _:b496049188 "13"^^ . _:b496050040 . _:b496049187 "13"^^ . . _:b496050043 . . . _:b496050042 . _:b496050053 . . _:b496049181 . _:b496050052 . _:b496049199 "11"^^ . . _:b496050055 . _:b496049198 "11"^^ . _:b496050054 . _:b496049197 "11"^^ . . . _:b496049431 . _:b496050049 . _:b496049196 "12"^^ . _:b496050048 . _:b496049939 . _:b496050331 . _:b496049195 "12"^^ . _:b496049934 . _:b496050051 . _:b496049538 . . _:b496049194 "12"^^ . . . . _:b496050050 . _:b496049193 "12"^^ . _:b496050061 . _:b496049587 . _:b496049192 "12"^^ . _:b496049945 . _:b496050060 . _:b496049207 "10"^^ . . _:b496050063 . _:b496050187 . _:b496049206 "10"^^ . _:b496050062 . . _:b496049205 "11"^^ . _:b496050057 . _:b496049204 "11"^^ . _:b496050056 . _:b496049203 "11"^^ . _:b496050059 . _:b496049202 "11"^^ . . _:b496049206 . _:b496050058 . _:b496049201 "11"^^ . _:b496050069 . _:b496049200 "11"^^ . . _:b496050068 . _:b496049215 "10"^^ . . . _:b496049267 . . _:b496050071 . _:b496049214 "10"^^ . . _:b496049610 . _:b496049213 "10"^^ . _:b496050070 . _:b496050065 . _:b496049212 "10"^^ . _:b496049374 . . _:b496050099 . _:b496050064 . _:b496049211 "10"^^ . _:b496050067 . _:b496049210 "10"^^ . _:b496050091 . _:b496050066 . _:b496049849 . _:b496049209 "10"^^ . _:b16663540 "Calf thymus histones were obtained from Roche, and poly-nucleosomes were purified from HeLa cells as previously described>>33<<. Histone peptides were synthesized at the Yale W. M. Keck peptide synthesis facility, and liquid chromatography mass spectrometry was performed at the Stanford University Vincent Coates Foundation Mass Spectrometry Laboratory. To" . _:b496049724 . _:b496049208 "10"^^ . _:b496050077 . _:b496050398 . _:b496050076 . _:b496049222 "9"^^ . _:b496050079 . . _:b496049223 "9"^^ . _:b496050078 . _:b16663547 "The GO analysis was performed using DAVID Bioinformatics Resources 6.7 (http://david.abcc.ncifcrf.gov) >>39<<,40." . _:b496049220 "9"^^ . _:b496050073 . . _:b496049464 . _:b496049221 "9"^^ . _:b496050072 . _:b496049219 "10"^^ . . . _:b496050075 . _:b496049218 "10"^^ . . . _:b496049217 "10"^^ . . _:b496050074 . _:b496050025 . _:b496050085 . _:b496049216 "10"^^ . _:b496049402 . _:b496050084 . . _:b496049230 "8"^^ . _:b496049781 . . _:b496050087 . _:b496049231 "8"^^ . _:b496050086 . _:b496049228 "8"^^ . _:b496050081 . _:b496050359 . _:b496049229 "8"^^ . _:b496050080 . _:b496049226 "9"^^ . _:b496050083 . _:b496049227 "9"^^ . . _:b496050082 . _:b496049766 . _:b496050229 . _:b496049224 "9"^^ . _:b496050093 . _:b496049225 "9"^^ . . _:b496050092 . _:b496049238 "8"^^ . _:b496050095 . _:b496050144 . _:b496049239 "8"^^ . _:b496050094 . _:b496049377 . _:b496049236 "8"^^ . _:b496049794 . _:b496050089 . _:b496049237 "8"^^ . _:b496050088 . . _:b496049234 "8"^^ . _:b496050091 . . _:b496049235 "8"^^ . . _:b496050090 . _:b496049232 "8"^^ . _:b496050101 . . _:b496049233 "8"^^ . . _:b496050100 . _:b496050288 . _:b496049246 "8"^^ . _:b496050103 . _:b496049247 "8"^^ . _:b496050336 . _:b496050102 . . _:b496049244 "8"^^ . _:b496050097 . . _:b496049941 . _:b496049245 "8"^^ . _:b496050096 . _:b496049242 "8"^^ . _:b496050099 . . _:b496049243 "8"^^ . _:b496050098 . _:b496049240 "8"^^ . _:b496050109 . _:b496049241 "8"^^ . _:b496050178 . _:b496050108 . _:b496049254 "7"^^ . . _:b496050111 . _:b496049255 "7"^^ . _:b496050110 . _:b496049252 "7"^^ . . _:b496050105 . _:b496049253 "7"^^ . _:b496049883 . _:b496050104 . _:b496049250 "7"^^ . . _:b496050107 . . _:b496049251 "7"^^ . _:b496049954 . _:b496050106 . _:b496049248 "8"^^ . _:b496050117 . _:b496050168 . _:b496049249 "7"^^ . _:b496049168 . _:b496050116 . _:b496049262 "7"^^ . _:b496050119 . _:b496049295 . _:b496049263 "7"^^ . _:b496050171 . . . _:b496050118 . _:b496049260 "7"^^ . _:b496050113 . _:b496049261 "7"^^ . _:b496050112 . _:b496049258 "7"^^ . _:b496050115 . _:b496049259 "7"^^ . _:b496050114 . _:b496049256 "7"^^ . _:b496049230 . _:b496050125 . _:b496049746 . _:b496049257 "7"^^ . . _:b496050124 . _:b496049270 "6"^^ . . _:b496050127 . _:b496049271 "6"^^ . _:b496050126 . _:b496049268 "7"^^ . _:b496049863 . _:b496049221 . _:b496050121 . _:b496049269 "7"^^ . . . _:b496050120 . . _:b496049266 "7"^^ . _:b496050123 . _:b496049267 "7"^^ . _:b496049244 . _:b496049830 . _:b496050122 . _:b496049264 "7"^^ . _:b496049783 . _:b496050133 . _:b496049265 "7"^^ . _:b496049346 . _:b496050132 . _:b496049278 "6"^^ . _:b496049200 . _:b496050135 . _:b496049279 "6"^^ . . _:b16663534 . _:b496050134 . _:b496049276 "6"^^ . _:b496049430 . _:b16663535 . _:b496050129 . _:b496049277 "6"^^ . _:b496050128 . _:b496049274 "6"^^ . _:b496050131 . _:b496049275 "6"^^ . _:b496050130 . _:b496049272 "6"^^ . . _:b496050141 . . _:b496049273 "6"^^ . _:b16663540 . _:b496050140 . _:b496049286 "6"^^ . _:b16663541 . . _:b496049287 "6"^^ . _:b496050143 . _:b496050140 . _:b16663542 . . _:b496050142 . _:b496049284 "6"^^ . . _:b16663543 . _:b496050137 . _:b496049285 "6"^^ . _:b16663536 . _:b496050136 . _:b496049282 "6"^^ . _:b496049546 . _:b16663537 . _:b496050205 . _:b496050139 . _:b496049283 "6"^^ . _:b16663538 . . _:b496050138 . _:b496049280 "6"^^ . _:b16663539 . . _:b496050149 . _:b496049281 "6"^^ . _:b16663548 . _:b496050148 . _:b496049294 "6"^^ . _:b496050243 . _:b16663549 . _:b496050151 . _:b496049295 "6"^^ . _:b496049727 . _:b16663550 . _:b496050150 . _:b496049292 "6"^^ . _:b16663551 . _:b496050145 . _:b496049293 "6"^^ . _:b16663544 . _:b496049186 . _:b496050144 . . _:b496049290 "6"^^ . . _:b16663545 . _:b16663547 . _:b496050147 . _:b496049291 "6"^^ . _:b16663546 . _:b496050146 . _:b496049288 "6"^^ . _:b16663547 . _:b496050389 . _:b496050157 . _:b496049289 "6"^^ . _:b496050156 . _:b496049302 "6"^^ . . _:b496049303 "6"^^ . _:b496050159 . . _:b496049300 "6"^^ . _:b496050158 . . . _:b496050153 . _:b496049301 "6"^^ . _:b496050152 . _:b496049298 "6"^^ . _:b496050155 . _:b496049299 "6"^^ . . _:b496050154 . _:b496049296 "6"^^ . . _:b496050135 . . _:b496049297 "6"^^ . _:b496050165 . . . _:b496049310 "6"^^ . _:b496050164 . _:b496049291 . _:b496050167 . _:b496049311 "6"^^ . _:b496050166 . . _:b496049308 "6"^^ . _:b496050161 . _:b496049309 "6"^^ . . _:b496050160 . _:b496049306 "6"^^ . _:b496049449 . _:b496050163 . _:b496049307 "6"^^ . _:b496050162 . _:b496049304 "6"^^ . _:b496049203 . _:b496050173 . _:b496049305 "6"^^ . _:b496049528 . _:b496050172 . _:b496049317 "5"^^ . _:b496050175 . _:b496049316 "5"^^ . . _:b496050174 . . _:b496049319 "5"^^ . _:b496050169 . _:b496049318 "5"^^ . _:b496050168 . _:b496049313 "5"^^ . _:b496050171 . _:b496049312 "5"^^ . _:b496050170 . _:b496049315 "5"^^ . _:b496049669 . _:b496049776 . _:b496049314 "5"^^ . _:b496049668 . _:b496049984 . _:b496049437 . _:b496049325 "5"^^ . _:b496049671 . _:b496049480 . _:b496049324 "5"^^ . _:b496049670 . . _:b496049327 "5"^^ . _:b496050371 . _:b496049665 . _:b496049326 "5"^^ . _:b496049664 . _:b496049496 . . _:b496049321 "5"^^ . _:b496049667 . . _:b496049320 "5"^^ . _:b496049666 . . _:b496049323 "5"^^ . _:b496049677 . . _:b496049322 "5"^^ . _:b496049676 . _:b496049333 "5"^^ . _:b496049679 . . . _:b496049332 "5"^^ . _:b496049678 . _:b496049335 "5"^^ . _:b496049673 . _:b496049445 . _:b496049334 "5"^^ . . _:b496049672 . _:b496049329 "5"^^ . . _:b496049675 . _:b496050028 . _:b496049328 "5"^^ . _:b496049674 . . . _:b496049331 "5"^^ . _:b496049685 . _:b496049330 "5"^^ . _:b496049684 . . . _:b496049729 . . _:b496049341 "5"^^ . _:b496049687 . _:b496049340 "5"^^ . _:b496049686 . _:b496049343 "5"^^ . _:b496049681 . . _:b496049342 "5"^^ . . _:b496049680 . _:b496049337 "5"^^ . _:b496049683 . _:b496049336 "5"^^ . _:b496049682 . . _:b496049339 "5"^^ . _:b496049693 . _:b496049533 . _:b496049338 "5"^^ . _:b496049692 . _:b496049410 . _:b496049349 "5"^^ . _:b496049695 . _:b496049218 . _:b496049348 "5"^^ . _:b496049694 . . . _:b496049351 "5"^^ . _:b496049689 . _:b496049350 "5"^^ . _:b496049688 . _:b496049345 "5"^^ . _:b496049691 . _:b496049344 "5"^^ . _:b496049690 . _:b496049347 "5"^^ . _:b496049701 . _:b496049346 "5"^^ . _:b496049700 . _:b496049357 "5"^^ . _:b496049703 . _:b496050400 . _:b496049356 "5"^^ . _:b496049702 . _:b496049359 "5"^^ . _:b496049697 . _:b496049358 "5"^^ . _:b496049696 . _:b496049717 . _:b496049353 "5"^^ . _:b496049699 . _:b496049851 . _:b496049352 "5"^^ . _:b496049698 . _:b496049355 "5"^^ . _:b496049709 . . . _:b496049354 "5"^^ . _:b496049708 . _:b496049999 . _:b496049365 "5"^^ . _:b496049711 . . _:b496049364 "5"^^ . _:b496049710 . . _:b496049367 "5"^^ . _:b496049705 . _:b496049918 . _:b496049366 "5"^^ . _:b496049704 . _:b496049361 "5"^^ . _:b496049707 . _:b496049360 "5"^^ . _:b496049848 . _:b496049706 . _:b16663534 "methods" . _:b496050241 . _:b496049363 "5"^^ . _:b496049717 . _:b496049362 "5"^^ . _:b496049716 . . _:b496049373 "5"^^ . _:b496049719 . . . . _:b496049372 "5"^^ . _:b496049718 . _:b496049375 "4"^^ . _:b496049300 . . _:b496049713 . . _:b496049374 "5"^^ . _:b496049712 . _:b496049312 . _:b496049369 "5"^^ . _:b496049715 . _:b496050151 . _:b496049368 "5"^^ . _:b496049714 . _:b496049371 "5"^^ . _:b496049725 . _:b496049370 "5"^^ . _:b496049724 . _:b496049381 "4"^^ . _:b496050228 . _:b496049727 . _:b496049380 "4"^^ . . . _:b496049726 . _:b496049383 "4"^^ . _:b496049721 . _:b496049382 "4"^^ . _:b496049866 . _:b496049720 . _:b496050340 . _:b496049266 . _:b496049377 "4"^^ . _:b496049723 . _:b496049376 "4"^^ . _:b496049722 . _:b496049379 "4"^^ . _:b496049733 . . _:b496049378 "4"^^ . _:b496049732 . _:b496049292 . _:b496049389 "4"^^ . _:b496049735 . . _:b496049388 "4"^^ . _:b496049734 . _:b496049391 "4"^^ . . _:b496049729 . _:b496049390 "4"^^ . _:b496049728 . _:b496049385 "4"^^ . _:b496049731 . . _:b496049384 "4"^^ . 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