_:b523489014 "4"^^ . _:b523489318 . _:b523489933 . _:b523489009 "4"^^ . _:b523489136 . _:b523489313 . _:b523489008 "4"^^ . _:b523489312 . _:b523488817 . _:b523489011 "4"^^ . _:b523489315 . . . _:b523489010 "4"^^ . _:b523489314 . . _:b523489021 "4"^^ . _:b523489325 . _:b523489020 "4"^^ . _:b523489324 . . _:b523489023 "4"^^ . _:b523489327 . _:b523489022 "4"^^ . _:b523489548 . _:b523489326 . _:b523489045 . . _:b523489321 . . _:b523489017 "4"^^ . _:b523489111 . _:b523489016 "4"^^ . . _:b523489320 . _:b523489019 "4"^^ . _:b523489323 . _:b523489725 . . _:b523489018 "4"^^ . _:b523489322 . _:b523489029 "4"^^ . _:b523489333 . _:b523489028 "4"^^ . _:b523489332 . . _:b523489031 "4"^^ . _:b523489335 . . . _:b523489030 "4"^^ . _:b523489334 . . _:b523489025 "4"^^ . . _:b523489329 . _:b523489024 "4"^^ . _:b523489131 . _:b523489328 . _:b523489027 "4"^^ . _:b523489331 . _:b523489088 . _:b523489026 "4"^^ . _:b22745145 "PiB retention in the FLR region is substantial in patients with diagnosed AD and has been used as a summary measure of PiB retention in previous studies33, >>34<<, 39. 1.25 is the value used to separate PiB+ and PiB\u2212 in the HAB cohort, and 1.5 is used to delineate between PiB+ and PiB\u2212 in the ADNI cohort." . _:b523489330 . _:b523489037 "4"^^ . _:b523489341 . _:b523488890 . _:b523489036 "4"^^ . _:b523489340 . _:b523489172 . _:b523489039 "4"^^ . _:b523489343 . _:b523489076 . . _:b523489038 "4"^^ . _:b523489342 . _:b523489033 "4"^^ . _:b523489337 . . _:b523490015 . _:b523489884 . _:b523489032 "4"^^ . _:b523489783 . _:b523489336 . _:b523489973 . _:b523490180 . _:b523489035 "4"^^ . _:b523489339 . _:b523489952 . _:b523489801 . _:b523489034 "4"^^ . _:b523489338 . _:b523489045 "4"^^ . _:b523489349 . _:b523489044 "4"^^ . _:b523489348 . . . _:b523489351 . _:b523489047 "4"^^ . . _:b523489285 . _:b523489297 . _:b523489046 "4"^^ . _:b523489350 . . . _:b523489345 . _:b523489041 "4"^^ . _:b523489833 . . . _:b523489040 "4"^^ . _:b523489344 . . _:b523489803 . _:b523489043 "4"^^ . _:b523489347 . . _:b523489042 "4"^^ . _:b523489346 . _:b523489053 "4"^^ . . _:b523489357 . . _:b523489052 "4"^^ . _:b523489356 . . _:b523489055 "4"^^ . _:b523489359 . . _:b523489054 "4"^^ . _:b523489358 . _:b523489049 "4"^^ . _:b523489353 . . _:b523489048 "4"^^ . _:b523489352 . . . _:b523489503 . _:b523489051 "4"^^ . _:b523489355 . _:b523489050 "4"^^ . _:b523489354 . _:b523489061 "4"^^ . _:b523489365 . _:b523489837 . _:b523489060 "4"^^ . _:b523489364 . _:b523489031 . _:b523489063 "4"^^ . _:b523489367 . . _:b523489062 "4"^^ . _:b523489366 . _:b523489057 "4"^^ . _:b523489361 . . _:b523489002 . _:b523489056 "4"^^ . _:b523489360 . . _:b523489059 "4"^^ . . _:b523489363 . _:b523489058 "4"^^ . _:b523489141 . _:b523489362 . _:b523489069 "4"^^ . . _:b523489373 . _:b523489068 "4"^^ . _:b523489372 . _:b523489071 "4"^^ . _:b523489375 . _:b523489070 "4"^^ . _:b523489374 . . _:b523489065 "4"^^ . _:b523489369 . . _:b523488806 . _:b523489064 "4"^^ . _:b523489880 . _:b523489368 . _:b523489067 "4"^^ . _:b523489371 . _:b523489066 "4"^^ . _:b523489370 . . _:b523489426 . _:b523488760 . . _:b523489077 "4"^^ . _:b523489381 . . _:b523489773 . _:b523489076 "4"^^ . _:b523489893 . _:b523489380 . _:b523489079 "4"^^ . _:b523489383 . . _:b523489078 "4"^^ . _:b523489382 . _:b523489083 . _:b523489073 "4"^^ . _:b523489377 . _:b523489072 "4"^^ . _:b523489376 . _:b523489075 "4"^^ . _:b523489379 . _:b523489074 "4"^^ . _:b523489378 . _:b523489085 "4"^^ . _:b523489389 . . _:b523489084 "4"^^ . . _:b523489388 . _:b523489087 "4"^^ . _:b523489391 . _:b523489086 "4"^^ . _:b523489390 . _:b523489081 "4"^^ . _:b523489385 . _:b523490054 . _:b523490149 . _:b523488931 . _:b523489080 "4"^^ . _:b523489384 . _:b523489202 . _:b523490171 . _:b523489083 "4"^^ . _:b523489387 . _:b523489082 "4"^^ . _:b523490134 . _:b523489386 . _:b523489093 "3"^^ . _:b523489397 . _:b523488920 . _:b523488749 . _:b523489092 "3"^^ . _:b523489396 . _:b523490061 . . _:b523488748 . _:b523489095 "3"^^ . _:b523489399 . _:b523488751 . _:b523489094 "3"^^ . _:b523489398 . _:b523488750 . _:b523489089 "4"^^ . _:b523489393 . _:b523489088 "4"^^ . _:b523489392 . _:b523489536 . _:b523488903 . _:b523489091 "4"^^ . _:b523489395 . _:b523488747 . _:b523489090 "4"^^ . _:b523489394 . _:b523488746 . _:b523489101 "3"^^ . _:b523490221 . _:b523489405 . _:b523489459 . . . _:b523488757 . _:b523489100 "3"^^ . . _:b523489404 . . _:b523488756 . _:b523490042 . _:b523489103 "3"^^ . . _:b523489407 . _:b523488759 . _:b523489102 "3"^^ . . _:b523489406 . _:b523489367 . _:b523488758 . _:b523489097 "3"^^ . _:b523489401 . _:b523490217 . _:b523488753 . _:b523489096 "3"^^ . _:b523489400 . _:b523488752 . _:b523489099 "3"^^ . _:b523489403 . . _:b523488755 . _:b523489098 "3"^^ . . . _:b523489402 . _:b523488754 . _:b523489109 "3"^^ . _:b523489758 . _:b523489413 . . _:b523488765 . _:b523489108 "3"^^ . _:b523489412 . . _:b523488764 . _:b523489111 "3"^^ . _:b523489415 . _:b523488767 . _:b523489110 "3"^^ . _:b523489414 . _:b523488766 . _:b523489105 "3"^^ . _:b523489409 . . _:b523488761 . _:b523489104 "3"^^ . _:b523489408 . . _:b523488760 . _:b523489107 "3"^^ . _:b523489411 . _:b523489284 . . _:b523488763 . _:b523489106 "3"^^ . _:b523490232 . _:b523489410 . . _:b523488762 . _:b523489117 "3"^^ . . _:b523489421 . _:b523489116 "3"^^ . _:b523489420 . _:b523489119 "3"^^ . _:b523489579 . _:b523489423 . _:b523489400 . _:b523489118 "3"^^ . _:b523489422 . _:b523489113 "3"^^ . _:b523489417 . . _:b523489112 "3"^^ . . . _:b523489416 . _:b523489115 "3"^^ . _:b523489419 . . _:b523489114 "3"^^ . _:b523489418 . _:b523489207 . _:b523489125 "3"^^ . _:b523489429 . _:b523489124 "3"^^ . _:b523489428 . . _:b523489127 "3"^^ . _:b523490064 . _:b523489431 . . _:b523489126 "3"^^ . _:b523489430 . _:b523488981 . _:b523489121 "3"^^ . _:b523489425 . . _:b523489976 . _:b523489120 "3"^^ . _:b523489424 . _:b523489123 "3"^^ . _:b523489427 . _:b523489609 . _:b523489122 "3"^^ . _:b523489426 . _:b523489137 . _:b523489133 "3"^^ . . _:b523489437 . _:b523489051 . . _:b523489132 "3"^^ . _:b523489436 . _:b523489135 "3"^^ . _:b523488986 . . _:b523489439 . _:b523489134 "3"^^ . _:b523489438 . _:b523489375 . . _:b523489129 "3"^^ . _:b523490148 . _:b523489433 . _:b523489261 . _:b523489128 "3"^^ . _:b523490085 . _:b523489432 . . _:b523489084 . . _:b523489131 "3"^^ . _:b523489435 . _:b523489130 "3"^^ . _:b523489434 . _:b523489141 "3"^^ . . _:b523489445 . _:b523489140 "3"^^ . _:b523489444 . _:b523489793 . _:b523489143 "3"^^ . . _:b523489447 . _:b523489658 . _:b523489061 . . _:b523489142 "3"^^ . _:b523489446 . _:b523490138 . _:b523489137 "3"^^ . _:b523489441 . _:b523489136 "3"^^ . _:b523489440 . . _:b523488785 . _:b523489139 "3"^^ . _:b523489443 . _:b523489870 . _:b523489138 "3"^^ . _:b523489442 . _:b523490059 . . _:b523489149 "3"^^ . _:b523489453 . _:b523489148 "3"^^ . . _:b523489452 . _:b523489151 "3"^^ . _:b523489662 . _:b523489455 . _:b523489797 . _:b523489150 "3"^^ . _:b523489454 . . . _:b523489145 "3"^^ . . _:b523489449 . . . _:b523489144 "3"^^ . _:b523489448 . _:b523489147 "3"^^ . _:b523489451 . . . _:b523489146 "3"^^ . . . _:b523489450 . _:b523489157 "3"^^ . _:b523489461 . . _:b523489156 "3"^^ . _:b22745130 . _:b523489460 . _:b523489159 "3"^^ . _:b523489463 . _:b523489158 "3"^^ . _:b523489462 . _:b523489491 . _:b523489153 "3"^^ . _:b523489457 . _:b523489152 "3"^^ . _:b523489456 . _:b523489155 "3"^^ . _:b523489459 . . _:b523489154 "3"^^ . _:b523489458 . _:b523489165 "3"^^ . _:b523489469 . _:b523490151 . _:b523490076 . _:b523489164 "3"^^ . _:b523489468 . . _:b523489167 "3"^^ . . . _:b523489471 . . . _:b523489166 "3"^^ . _:b523489470 . _:b523489944 . _:b523489751 . _:b523489161 "3"^^ . _:b523489465 . _:b523489160 "3"^^ . _:b523489464 . _:b523489163 "3"^^ . _:b523489467 . _:b523489162 "3"^^ . _:b523489466 . . . _:b523489173 "3"^^ . _:b523489537 . _:b523489477 . _:b523489172 "3"^^ . _:b523489476 . _:b523489175 "3"^^ . _:b523489479 . _:b523490114 . _:b523489294 . _:b523489174 "3"^^ . _:b523489478 . . _:b523489595 . _:b523488964 . _:b523489169 "3"^^ . _:b523489473 . _:b523489788 . _:b523489168 "3"^^ . _:b523489472 . _:b523489171 "3"^^ . . _:b523489475 . _:b523489170 "3"^^ . _:b523489474 . _:b523489181 "3"^^ . _:b523489485 . . _:b523489180 "3"^^ . . _:b523489287 . _:b523489484 . . _:b523488851 . _:b523489183 "3"^^ . . . _:b523490212 . _:b523489487 . . _:b523489182 "3"^^ . _:b523490211 . . _:b523489486 . _:b523489177 "3"^^ . _:b523489481 . _:b523489166 . _:b523489176 "3"^^ . _:b523489480 . _:b523490154 . _:b523489179 "3"^^ . _:b523489483 . . _:b523489178 "3"^^ . _:b523489482 . _:b523488959 . _:b523489189 "3"^^ . _:b523489493 . _:b523489712 . _:b523489188 "3"^^ . _:b523489492 . . _:b523489191 "3"^^ . _:b523489495 . _:b523489363 . _:b523489506 . _:b523489350 . _:b523489190 "3"^^ . _:b523489494 . _:b523489627 . _:b523489185 "3"^^ . _:b523489489 . . _:b523489184 "3"^^ . _:b523489488 . . . _:b523489187 "3"^^ . _:b523489529 . _:b523489491 . _:b523489186 "3"^^ . _:b523489490 . . _:b523489197 "3"^^ . _:b523489501 . . _:b523489196 "3"^^ . _:b523489127 . _:b523489500 . _:b523489628 . _:b523489199 "3"^^ . _:b523489503 . _:b523489993 . _:b523489198 "3"^^ . _:b523489502 . . _:b523489193 "3"^^ . _:b523489497 . _:b523489192 "3"^^ . . _:b523489326 . _:b523489496 . . _:b523489195 "3"^^ . _:b523489499 . _:b523490080 . _:b523489194 "3"^^ . . . _:b523489498 . _:b523488953 . _:b523489205 "3"^^ . _:b523489509 . _:b523490124 . _:b523489204 "3"^^ . _:b523489862 . _:b523489508 . _:b523489750 . _:b523489207 "3"^^ . _:b523489511 . _:b523489394 . _:b523489206 "3"^^ . _:b523489510 . . _:b523489201 "3"^^ . _:b523489248 . _:b523489505 . _:b523489200 "3"^^ . _:b523489504 . _:b523489203 "3"^^ . _:b523489507 . . _:b523489202 "3"^^ . . _:b523489469 . _:b523489506 . . . _:b523489213 "3"^^ . . _:b523489517 . _:b523489216 . _:b523489212 "3"^^ . _:b523489302 . _:b523489516 . _:b523489215 "3"^^ . _:b523489519 . _:b523489022 . _:b523489214 "3"^^ . _:b523489518 . . _:b523489262 . . _:b523489209 "3"^^ . . _:b523489513 . . _:b523489208 "3"^^ . . _:b523489512 . _:b523488976 . _:b523489211 "3"^^ . _:b523489515 . _:b523489575 . _:b523488898 . _:b523489210 "3"^^ . _:b523489514 . _:b523489221 "3"^^ . _:b523488955 . _:b523489525 . _:b523489258 . _:b523489220 "3"^^ . _:b523489524 . _:b523489238 . _:b523489652 . _:b523489223 "3"^^ . _:b523489316 . _:b523489527 . _:b523489222 "3"^^ . _:b523489526 . _:b523488854 . _:b523489217 "3"^^ . _:b523488866 . _:b523490099 . _:b523489669 . _:b523489521 . . _:b523488991 . _:b523489216 "3"^^ . _:b523489520 . _:b523489219 "3"^^ . . _:b523489523 . _:b523489218 "3"^^ . _:b523489220 . _:b523489522 . _:b523489329 . _:b523489229 "3"^^ . _:b523489533 . _:b523489228 "3"^^ . _:b523489532 . _:b523489943 . . . _:b523489231 "3"^^ . . _:b523489535 . _:b523489230 "3"^^ . . _:b523489534 . . _:b523489225 "3"^^ . _:b523489529 . _:b523489224 "3"^^ . _:b523489528 . _:b523489227 "3"^^ . _:b523489531 . _:b523489226 "3"^^ . _:b523489530 . . _:b523489237 "3"^^ . _:b523489236 "3"^^ . . _:b523489239 "3"^^ . _:b523489786 . _:b523489238 "3"^^ . _:b523489233 "3"^^ . _:b523489232 "3"^^ . _:b523489235 "3"^^ . . . _:b523489234 "3"^^ . _:b523488974 . _:b523489663 . _:b523489245 "3"^^ . _:b523489244 "3"^^ . _:b523489247 "3"^^ . _:b523489246 "3"^^ . _:b523489521 . _:b523489241 "3"^^ . . _:b523489240 "3"^^ . _:b523489444 . _:b523489556 . _:b523489243 "3"^^ . . _:b523489128 . _:b523489810 . _:b523489242 "3"^^ . _:b523489104 . _:b523489253 "3"^^ . _:b523489139 . _:b523489049 . _:b523489843 . _:b523489252 "3"^^ . . _:b523489255 "3"^^ . _:b523489771 . . _:b523489254 "3"^^ . . . _:b523489249 "3"^^ . _:b523489248 "3"^^ . . _:b523489772 . _:b523489251 "3"^^ . . _:b523489250 "3"^^ . _:b523489261 "3"^^ . _:b523489298 . _:b523490178 . _:b523489824 . . _:b523489260 "3"^^ . _:b523489263 "3"^^ . _:b523489447 . . _:b523489262 "3"^^ . . _:b523489257 "3"^^ . . _:b523489256 "3"^^ . _:b523489259 "3"^^ . _:b523490186 . _:b523489258 "3"^^ . _:b523490142 . _:b523489269 "3"^^ . . _:b523489268 "3"^^ . _:b523489271 "3"^^ . . _:b523489270 "3"^^ . . _:b523489293 . . _:b523489265 "3"^^ . . _:b523489264 "3"^^ . _:b523489401 . _:b523489267 "3"^^ . _:b523489299 . _:b523489016 . _:b523489266 "3"^^ . _:b523489277 "3"^^ . _:b523490032 . _:b523489276 "3"^^ . . _:b523489279 "3"^^ . . . _:b523489278 "3"^^ . _:b523489792 . _:b523489273 "3"^^ . _:b523489272 "3"^^ . . _:b523489275 "3"^^ . _:b523489274 "3"^^ . . _:b523489960 . _:b523489761 . _:b523489028 . _:b523489767 . . _:b523489343 . . _:b523489954 . _:b523489623 . _:b523490227 . . . . . _:b523490026 . . . . _:b523489211 . . . . _:b523489518 . . _:b523490200 . . . _:b523489985 . . _:b523489205 . _:b523489539 . _:b523489525 . . . . _:b523489530 . _:b523489398 . . . . _:b523489931 . . _:b523489075 . . . . _:b523488810 . _:b523488979 . . . . . . . _:b523488926 . . . "10.1038%2Fnn.3435" . _:b523489908 . _:b523488906 . _:b523489167 . . . . _:b523488874 . _:b523489975 . _:b523489149 . _:b523489499 . . _:b523490067 . . . . . . _:b523490175 . . _:b523489797 "2"^^ . _:b523489592 . _:b523489796 "2"^^ . _:b523489408 . _:b523489799 "2"^^ . _:b523489798 "2"^^ . _:b22745146 "PiB retention in the FLR region is substantial in patients with diagnosed AD and has been used as a summary measure of PiB retention in previous studies33, 34, >>39<<. 1.25 is the value used to separate PiB+ and PiB\u2212 in the HAB cohort, and 1.5 is used to delineate between PiB+ and PiB\u2212 in the ADNI cohort." . _:b523489793 "2"^^ . . _:b523489792 "2"^^ . _:b523490116 . _:b523489795 "2"^^ . _:b523489598 . _:b523489292 . _:b523489794 "2"^^ . _:b523489805 "2"^^ . . _:b523489804 "2"^^ . _:b523488918 . _:b523489807 "2"^^ . _:b523489806 "2"^^ . . _:b523488994 . _:b523489801 "2"^^ . _:b523488897 . _:b523489800 "2"^^ . _:b523489711 . . _:b523489803 "2"^^ . _:b523490105 . _:b523489802 "2"^^ . _:b523488932 . _:b523489813 "2"^^ . . _:b523489485 . _:b523489812 "2"^^ . _:b523489224 . _:b523489815 "2"^^ . _:b523489814 "2"^^ . _:b523489809 "2"^^ . . _:b523490118 . _:b523489808 "2"^^ . . _:b523489978 . . _:b523489811 "2"^^ . . _:b523489810 "2"^^ . _:b523489821 "2"^^ . _:b523489632 . _:b523489820 "2"^^ . _:b523489823 "2"^^ . _:b523489822 "2"^^ . _:b523489450 . _:b523490220 . _:b523489317 . _:b523489817 "2"^^ . . _:b523489822 . _:b523489816 "2"^^ . . _:b523489374 . _:b523489819 "2"^^ . _:b523489818 "2"^^ . . _:b523489829 "2"^^ . . . _:b523489000 . _:b22745147 "In addition to include a covariate for experimental batch in our models where appropriate, to correct for potential batch effects we have also applied an Empirical Bayes priors distribution estimation framework (Combat v. 2.0)>>40<<, as implemented in Gene Pattern41 using a parametric method." . _:b523489828 "2"^^ . _:b523489831 "2"^^ . _:b523488943 . _:b523489830 "2"^^ . _:b523489406 . . _:b523489825 "2"^^ . _:b523490013 . _:b523488963 . _:b523489824 "2"^^ . _:b523489616 . . . _:b523489827 "2"^^ . . _:b523489796 . _:b523489826 "2"^^ . _:b523489666 . _:b523489837 "2"^^ . _:b523489836 "2"^^ . _:b523489311 . _:b523489839 "2"^^ . _:b523489838 "2"^^ . . _:b523488788 . _:b523489833 "2"^^ . . _:b523489832 "2"^^ . _:b523489835 "2"^^ . . _:b523489834 "2"^^ . _:b523489391 . _:b523489845 "2"^^ . _:b523489844 "2"^^ . _:b523490036 . . _:b523489847 "2"^^ . _:b523488790 . _:b523489846 "2"^^ . _:b523488949 . _:b523489841 "2"^^ . . . . _:b523489840 "2"^^ . . _:b523489411 . . _:b523489843 "2"^^ . _:b523489842 "2"^^ . . . _:b523489853 "2"^^ . _:b523489852 "2"^^ . . . _:b523489855 "2"^^ . _:b523489314 . . _:b523489854 "2"^^ . . _:b523489246 . _:b523489849 "2"^^ . _:b523489848 "2"^^ . . _:b523489885 . _:b523489851 "2"^^ . . _:b523489901 . _:b523489850 "2"^^ . _:b523488752 . _:b523489861 "2"^^ . _:b523489860 "2"^^ . . _:b523489863 "2"^^ . _:b523489862 "2"^^ . _:b523489857 "2"^^ . _:b523489251 . _:b523489856 "2"^^ . _:b523489030 . _:b523489859 "2"^^ . _:b523489858 "2"^^ . _:b523489277 . . _:b523488922 . _:b523489869 "2"^^ . . _:b523489868 "2"^^ . . _:b523489871 "2"^^ . . _:b523489870 "2"^^ . _:b22745142 "Participants underwent PiB PET imaging as described previously33, >>34<<. Briefly, data were acquired using a Siemens/CTI ECAT HR scanner (3D mode; 63 image planes; 15.2 cm axial field of view; 5.6 mm transaxial resolution and 2.4 mm slice interval; 39 frames:" . _:b523489865 "2"^^ . . _:b523489864 "2"^^ . . _:b523489867 "2"^^ . _:b523490041 . _:b523489866 "2"^^ . _:b523489877 "2"^^ . _:b523489613 . . _:b523489876 "2"^^ . _:b523489879 "2"^^ . _:b523489053 . _:b22745134 "Brains were removed in a standard fashion as previously described>>27<<\u201329. After weighing, each brain was cut into 1cm coronal slabs using a Plexiglas jig." . _:b523489737 . _:b523489878 "2"^^ . . _:b523489972 . _:b523489873 "2"^^ . _:b523489872 "2"^^ . _:b523489875 "2"^^ . _:b523489874 "2"^^ . _:b523489089 . _:b523489142 . _:b523489885 "2"^^ . . . . _:b523489884 "2"^^ . _:b523490152 . . _:b523489352 . _:b523489887 "2"^^ . _:b523489886 "2"^^ . _:b523489881 "2"^^ . _:b523488859 . _:b523489678 . _:b523489535 . . _:b523489880 "2"^^ . . . _:b523489919 . _:b523489883 "2"^^ . . _:b523489882 "2"^^ . . _:b523489893 "2"^^ . _:b523489892 "2"^^ . . _:b523489895 "2"^^ . _:b523489894 "2"^^ . . _:b523489889 "2"^^ . _:b523490047 . . . _:b523490025 . . _:b523489888 "2"^^ . _:b523489891 "2"^^ . _:b523489890 "2"^^ . . _:b523489901 "2"^^ . _:b523489900 "2"^^ . _:b523489146 . _:b523489903 "2"^^ . _:b523489902 "2"^^ . _:b523489081 . _:b523488907 . . _:b523489897 "2"^^ . . _:b523489896 "2"^^ . _:b523489899 "2"^^ . . _:b523489898 "2"^^ . _:b523489839 . . _:b523489425 . _:b523489689 . _:b523489909 "2"^^ . _:b523489908 "2"^^ . _:b523489436 . _:b523489911 "2"^^ . . _:b523489495 . _:b523490176 . _:b523489910 "2"^^ . _:b523489905 "2"^^ . . _:b523489904 "2"^^ . _:b523489907 "2"^^ . _:b523489634 . . _:b523489906 "2"^^ . _:b523489121 . _:b523489551 . . _:b523489917 "2"^^ . . _:b523489916 "2"^^ . _:b523488860 . _:b523489919 "2"^^ . . _:b523489918 "2"^^ . . _:b523489675 . _:b523489913 "2"^^ . _:b523489351 . _:b523489912 "2"^^ . . _:b523488921 . . _:b523489915 "2"^^ . _:b523489190 . . . _:b523489914 "2"^^ . _:b523490117 . _:b523489925 "2"^^ . _:b523489924 "2"^^ . . _:b523489927 "2"^^ . _:b523490198 . _:b523488972 . _:b523489926 "2"^^ . . _:b523489921 "2"^^ . _:b523489565 . _:b523489008 . _:b523489920 "2"^^ . _:b523489296 . _:b523489923 "2"^^ . _:b523489922 "2"^^ . . _:b523489933 "2"^^ . _:b523489932 "2"^^ . _:b523489935 "2"^^ . _:b523489934 "2"^^ . . _:b523489929 "2"^^ . _:b523489928 "2"^^ . _:b523488823 . _:b523489931 "2"^^ . _:b523489930 "2"^^ . . _:b523489604 . _:b523489941 "2"^^ . . . _:b523489940 "2"^^ . . _:b523489620 . . _:b523489943 "2"^^ . . _:b523489799 . _:b523489942 "2"^^ . _:b523488946 . _:b523489937 "2"^^ . _:b523489784 . _:b523489936 "2"^^ . _:b523489939 "2"^^ . _:b523489938 "2"^^ . _:b523489681 . _:b523489382 . _:b523489949 "2"^^ . . _:b523489948 "2"^^ . . _:b523489945 . _:b523489951 "2"^^ . . _:b523489950 "2"^^ . . _:b523489945 "2"^^ . _:b523489944 "2"^^ . . _:b523489947 "2"^^ . _:b523489946 "2"^^ . _:b523489766 . _:b523489957 "2"^^ . . _:b523489956 "2"^^ . _:b523488814 . _:b523489959 "2"^^ . . _:b523489958 "2"^^ . . _:b523489953 "2"^^ . . _:b523489952 "2"^^ . . . _:b523489955 "2"^^ . _:b523488983 . _:b523489954 "2"^^ . _:b523489965 "2"^^ . _:b523490155 . _:b523489964 "2"^^ . _:b523489967 "2"^^ . _:b523489966 "2"^^ . _:b523489961 "2"^^ . _:b523490201 . _:b523489960 "2"^^ . . _:b523489963 "2"^^ . _:b523489962 "2"^^ . . _:b523489973 "2"^^ . _:b523489667 . . _:b523489972 "2"^^ . . _:b523489953 . _:b523488995 . _:b523489975 "2"^^ . _:b523490056 . _:b523489974 "2"^^ . . _:b523489969 "2"^^ . _:b523489968 "2"^^ . _:b523489494 . . _:b523489971 "2"^^ . _:b523489970 "2"^^ . . . _:b523489981 "2"^^ . . _:b523489980 "2"^^ . . . _:b523489983 "2"^^ . _:b523489852 . _:b523489982 "2"^^ . _:b523489977 "2"^^ . _:b523488830 . _:b523489976 "2"^^ . . _:b523489979 "2"^^ . _:b523489978 "2"^^ . _:b523489278 . _:b523489989 "2"^^ . _:b523489988 "2"^^ . _:b523489991 "2"^^ . _:b523489990 "2"^^ . . _:b523489985 "2"^^ . _:b523489984 "2"^^ . _:b523489353 . . _:b523489987 "2"^^ . . _:b523490096 . _:b523489986 "2"^^ . . _:b523489828 . _:b523489997 "2"^^ . . _:b523489996 "2"^^ . . _:b523488941 . _:b523489999 "2"^^ . . _:b523490128 . _:b523489998 "2"^^ . _:b523488985 . _:b523489993 "2"^^ . . _:b523490001 . _:b523489992 "2"^^ . _:b523489995 "2"^^ . _:b523489994 "2"^^ . _:b523489830 . _:b523490005 "2"^^ . _:b523489338 . _:b523490004 "2"^^ . . . _:b523490007 "2"^^ . . _:b523488826 . _:b523490006 "2"^^ . _:b523490001 "2"^^ . _:b523490000 "2"^^ . _:b523489295 . _:b523489328 . _:b523489921 . _:b523490003 "2"^^ . _:b523489621 . _:b523490002 "2"^^ . _:b523490013 "2"^^ . _:b523489199 . . _:b523490012 "2"^^ . _:b523490015 "2"^^ . _:b523489571 . _:b523490014 "2"^^ . _:b523489044 . _:b523489058 . _:b523489342 . _:b523489653 . _:b523490009 "2"^^ . _:b523490008 "2"^^ . . _:b523490011 "2"^^ . _:b523490121 . _:b523490010 "2"^^ . _:b523488836 . . _:b523489964 . _:b523489840 . _:b523490021 "2"^^ . _:b523490020 "2"^^ . _:b523490023 "2"^^ . _:b523489578 . _:b523489731 . _:b523490022 "2"^^ . . . . _:b523490017 "2"^^ . _:b523490016 "2"^^ . . _:b523490019 "2"^^ . _:b523490018 "2"^^ . _:b523490029 "2"^^ . _:b523490028 "2"^^ . _:b523490086 . _:b523490031 "2"^^ . _:b523490095 . _:b523490030 "2"^^ . _:b523490025 "2"^^ . _:b523489763 . _:b523490024 "2"^^ . _:b523490027 "2"^^ . _:b523489384 . . _:b523490026 "2"^^ . . _:b523490037 "2"^^ . . _:b523490036 "2"^^ . _:b523490224 . _:b523490039 "2"^^ . _:b523488925 . _:b523488891 . _:b523489702 . _:b523490038 "2"^^ . . _:b523489876 . _:b523490033 "2"^^ . _:b523489834 . _:b523490032 "2"^^ . . _:b523490035 "2"^^ . . _:b523489143 . _:b523490034 "2"^^ . _:b523490045 "2"^^ . . . _:b523490044 "2"^^ . . . . _:b523489458 . _:b523490047 "2"^^ . _:b523488935 . _:b523490046 "2"^^ . _:b523490035 . _:b523490041 "2"^^ . . _:b523490040 "2"^^ . _:b523490043 "2"^^ . . _:b523489159 . . _:b523490042 "2"^^ . . _:b523490053 "2"^^ . _:b523489327 . _:b523490052 "2"^^ . . _:b523489514 . _:b523490055 "2"^^ . _:b523490209 . . _:b523490054 "2"^^ . _:b523489802 . _:b523490049 "2"^^ . _:b523490048 "2"^^ . _:b523490051 "2"^^ . _:b523490050 "2"^^ . _:b523490061 "2"^^ . _:b523490060 "2"^^ . _:b523489349 . . . _:b523490063 "2"^^ . _:b523489315 . _:b523490062 "2"^^ . _:b523490057 "2"^^ . _:b523489764 . _:b523490056 "2"^^ . . _:b523490059 "2"^^ . _:b523489925 . _:b523490058 "2"^^ . . . _:b523490069 "2"^^ . _:b523489707 . . . _:b523490068 "2"^^ . . _:b523490158 . _:b523490071 "2"^^ . _:b523490070 "2"^^ . . . _:b523489035 . _:b523490065 "2"^^ . . _:b523490064 "2"^^ . . _:b523489174 . _:b523489217 . _:b523490067 "2"^^ . . _:b523490066 "2"^^ . . . _:b523489617 . _:b523490077 "2"^^ . . _:b523490076 "2"^^ . _:b523490196 . _:b523489757 . _:b523490079 "2"^^ . . _:b523490078 "2"^^ . _:b523490073 "2"^^ . _:b22745129 "Rating of 021, performed no worse than 1.5 SD units below the age- and education-corrected norm on the Logical Memory IIa subtest of the Wechsler Memory Scale-Revised22, and scored 26 or above on the Mini-Mental State Examination>>23<<. Participants were excluded if previously diagnosed with a neurological or psychiatric condition or if they scored >11 on the Geriatric Depression Scale24." . . . _:b523490072 "2"^^ . _:b523490075 "2"^^ . _:b523488799 . . _:b523490074 "2"^^ . . _:b523490085 "2"^^ . _:b523488769 . _:b523489891 . _:b523490084 "2"^^ . _:b523489395 . _:b22745134 . _:b523490087 "2"^^ . _:b523489854 . _:b523490086 "2"^^ . _:b523489768 . _:b523490081 "2"^^ . . _:b523490080 "2"^^ . _:b523488990 . _:b523490083 "2"^^ . . _:b523489080 . . _:b523490082 "2"^^ . _:b523490093 "2"^^ . . . _:b523490092 "2"^^ . . _:b523490008 . _:b523490095 "2"^^ . _:b523490094 "2"^^ . _:b523490089 "2"^^ . . _:b523489780 . _:b523490088 "2"^^ . _:b523489304 . _:b523490091 "2"^^ . _:b523488970 . _:b523490090 "2"^^ . . _:b523488877 . _:b523490101 "2"^^ . _:b523489697 . _:b523490100 "2"^^ . . . _:b523489037 . _:b523490103 "2"^^ . _:b523489670 . _:b523489264 . _:b523490181 . _:b523489911 . . _:b523490102 "2"^^ . . . _:b523490097 "2"^^ . _:b523489977 . _:b523488870 . _:b523490230 . _:b523490096 "2"^^ . . _:b523489615 . _:b523490099 "2"^^ . . . _:b523490098 "2"^^ . _:b523490109 "2"^^ . _:b523489321 . . . _:b523490108 "2"^^ . _:b523490111 "2"^^ . _:b523488840 . _:b523490110 "2"^^ . _:b523490105 "2"^^ . _:b523489419 . _:b523490037 . _:b523490104 "2"^^ . _:b523489212 . _:b523490107 "2"^^ . . . _:b523489231 . _:b523490106 "2"^^ . . _:b523490117 "2"^^ . . _:b523489561 . _:b523490116 "2"^^ . _:b523490187 . _:b523490002 . _:b523490119 "2"^^ . . _:b523490118 "2"^^ . _:b523490113 "2"^^ . _:b523488915 . _:b523490112 "2"^^ . _:b523489807 . _:b523490115 "2"^^ . _:b523490120 . _:b523490114 "2"^^ . _:b523489701 . _:b523489013 . _:b523490125 "2"^^ . _:b523490124 "2"^^ . _:b523490127 "2"^^ . _:b523489515 . _:b523490126 "2"^^ . _:b523489794 . _:b523489543 . _:b523490121 "2"^^ . _:b523490120 "2"^^ . . _:b523490123 "2"^^ . _:b22745130 "Participants were excluded if previously diagnosed with a neurological or psychiatric condition or if they scored >11 on the Geriatric Depression Scale>>24<<. Participants provided informed consent in accordance with protocols approved by the Partners Healthcare Inc. Institutional Review Board." . _:b523490122 "2"^^ . . _:b523489480 . _:b523490133 "2"^^ . _:b523489735 . . _:b523490132 "2"^^ . . . _:b523489310 . _:b523490135 "2"^^ . _:b523490134 "2"^^ . . _:b523490129 "2"^^ . _:b523489742 . . _:b523490070 . _:b523490128 "2"^^ . _:b523490172 . . _:b523490131 "2"^^ . _:b523488900 . _:b523490130 "2"^^ . . _:b523489452 . _:b523490141 "2"^^ . _:b523489468 . . _:b523490140 "2"^^ . . _:b523490143 "2"^^ . . _:b523490142 "2"^^ . _:b523490137 "2"^^ . _:b523490136 "2"^^ . . _:b523490139 "2"^^ . _:b523490138 "2"^^ . . _:b523490149 "2"^^ . _:b523490191 . _:b523490148 "2"^^ . _:b523490072 . _:b523490151 "2"^^ . _:b523489319 . _:b523490150 "2"^^ . . _:b523490145 "2"^^ . _:b523489566 . _:b523488857 . _:b523490144 "2"^^ . . _:b523490147 "2"^^ . _:b523488803 . _:b523490146 "2"^^ . _:b523490157 "2"^^ . _:b523490156 "2"^^ . _:b523489340 . _:b523489364 . _:b523490159 "2"^^ . _:b523489523 . _:b523488774 . _:b523490158 "2"^^ . . _:b523489982 . _:b523489063 . _:b523490153 "2"^^ . _:b523489626 . _:b523489820 . _:b523489691 . _:b523490152 "2"^^ . _:b523490027 . _:b523490155 "2"^^ . _:b523490154 "2"^^ . _:b523489744 . . _:b523490165 "2"^^ . _:b523490164 "2"^^ . _:b523490167 "2"^^ . . _:b523490166 "2"^^ . _:b523490161 "2"^^ . _:b523488914 . _:b523489614 . . . _:b523490160 "2"^^ . . _:b523489241 . _:b523490163 "2"^^ . . _:b523490162 "2"^^ . _:b523489645 . _:b523490173 "2"^^ . _:b523490126 . . _:b523490172 "2"^^ . _:b523489020 . _:b523490175 "2"^^ . . _:b523490174 "2"^^ . _:b523489889 . _:b523490169 "2"^^ . _:b22745137 "For analyses, the neuropathologic diagnosis of AD was considered absent if NIA-Reagan diagnosis was no or low and present if intermediate or high likelihood>>29<<. The density of neuritic plaques, diffuse plaques and neurofibrillary tangles was characterized using Bielschowsky silver stain for visualization and a graticule to count total number of each in a 1-mm2 area (100 magnification) of highest" . _:b523490168 "2"^^ . _:b523490171 "2"^^ . . _:b523490170 "2"^^ . _:b523490181 "2"^^ . . _:b523489656 . _:b523490180 "2"^^ . _:b523490183 "2"^^ . . . _:b523489345 . _:b523490182 "2"^^ . _:b523490177 "2"^^ . _:b523490176 "2"^^ . . _:b523490179 "2"^^ . _:b523490178 "2"^^ . _:b523490189 "2"^^ . _:b523490005 . _:b523489362 . _:b523490188 "2"^^ . _:b523489563 . _:b523490191 "2"^^ . . _:b523490190 "2"^^ . _:b523489481 . _:b523490185 "2"^^ . . . _:b523490184 "2"^^ . . _:b523489896 . _:b523489413 . _:b523490187 "2"^^ . _:b523489222 . _:b523490186 "2"^^ . . . . _:b523490197 "2"^^ . . _:b523488888 . _:b523490196 "2"^^ . _:b523490199 "2"^^ . . . _:b523490198 "2"^^ . . _:b523490193 "2"^^ . _:b523490192 "2"^^ . _:b523490195 "2"^^ . . _:b523490194 "2"^^ . _:b523488971 . _:b523490205 "2"^^ . _:b523489996 . . . _:b523490204 "2"^^ . _:b523489009 . _:b523490207 "2"^^ . _:b523489074 . . _:b523490206 "2"^^ . _:b523488916 . _:b523490201 "2"^^ . . . _:b523489437 . _:b523490200 "2"^^ . _:b523489092 . _:b523490203 "2"^^ . . . _:b523490202 "2"^^ . _:b22745147 . _:b523489473 . _:b523490213 "2"^^ . _:b523490212 "2"^^ . . _:b523489661 . _:b523489569 . _:b523490215 "2"^^ . _:b523488778 . _:b523490063 . . _:b523490214 "2"^^ . _:b523489555 . _:b523490209 "2"^^ . _:b523488846 . _:b523489421 . _:b523490208 "2"^^ . . . _:b523490211 "2"^^ . _:b523490210 "2"^^ . . . _:b523490221 "2"^^ . . _:b523488751 "29"^^ . . _:b523490220 "2"^^ . _:b523488875 . _:b523490223 "2"^^ . _:b523489677 . _:b523490222 "2"^^ . . _:b523490217 "2"^^ . _:b523489196 . _:b523488754 "25"^^ . _:b523489239 . _:b523489255 . _:b523490216 "2"^^ . _:b523489140 . _:b523490219 "2"^^ . _:b523488747 "53"^^ . _:b523488752 "25"^^ . _:b523488755 "21"^^ . _:b523488749 "38"^^ . _:b523488852 . _:b523488748 "43"^^ . _:b523490218 "2"^^ . _:b523488750 "37"^^ . _:b523488753 "25"^^ . _:b523489755 . _:b523490229 "2"^^ . _:b523488757 "20"^^ . _:b523490228 "2"^^ . _:b523489451 . _:b523488756 "20"^^ . _:b523488759 "18"^^ . _:b523490231 "2"^^ . _:b523488838 . _:b523488758 "18"^^ . _:b523488950 . _:b523490230 "2"^^ . _:b523490225 "2"^^ . . . _:b523488760 "17"^^ . _:b523490224 "2"^^ . . _:b523489733 . _:b523488761 "17"^^ . _:b523490227 "2"^^ . _:b523488762 "16"^^ . _:b22745143 . . _:b523490226 "2"^^ . _:b523488763 "15"^^ . _:b523488812 . . _:b523488764 "15"^^ . _:b523489424 . _:b523488765 "15"^^ . . _:b523488746 "62"^^ . _:b523488766 "14"^^ . . _:b523488811 . . _:b523488767 "14"^^ . . . _:b523490233 "2"^^ . . _:b523490232 "2"^^ . . . . . . . _:b523489466 . _:b523489229 . . . _:b22745127 "online methods" . . _:b523490052 . _:b523490053 . _:b523489019 . _:b523490206 . _:b523490054 . _:b523490055 . _:b523490048 . _:b523489642 . . . _:b523490049 . _:b523490050 . _:b523490199 . _:b523489831 . _:b523490051 . . _:b523490060 . _:b523490061 . . _:b523490062 . _:b523490063 . _:b523490056 . . _:b523490057 . _:b523490058 . _:b523488791 . _:b523490059 . _:b523490068 . _:b523490069 . _:b523490070 . _:b523490071 . _:b523490064 . _:b523490065 . _:b523489769 . _:b523490066 . _:b523488793 . _:b523490043 . _:b523490067 . _:b523490076 . _:b523490077 . _:b523490078 . _:b523490079 . _:b523490072 . _:b523490073 . _:b523490074 . _:b523488780 . _:b523490075 . _:b523490084 . _:b523490085 . . _:b523490086 . _:b523490087 . _:b523489817 . _:b523490080 . . _:b523490081 . _:b523490082 . _:b523490083 . _:b523490092 . _:b523490093 . _:b523490069 . _:b523490094 . _:b523490095 . _:b523490088 . _:b523490089 . . _:b523490090 . _:b523490091 . _:b523490100 . _:b523490101 . _:b523490102 . _:b523490103 . _:b523490096 . _:b523490097 . _:b523490098 . _:b523490099 . _:b523490108 . . _:b523490109 . _:b523490110 . _:b523490111 . _:b523490104 . _:b523490105 . _:b523490106 . . . _:b523490107 . . _:b523490116 . _:b523490117 . _:b523490118 . _:b523490119 . _:b523490112 . . . _:b523489272 . _:b523490113 . _:b523490114 . _:b523490115 . _:b523490124 . _:b523490125 . _:b523490126 . _:b523490127 . _:b523490120 . _:b523490121 . _:b523489320 . _:b523490122 . _:b523489117 . _:b523490123 . _:b523490132 . _:b523490133 . _:b523490134 . _:b523490135 . _:b523490128 . _:b523490129 . _:b523490130 . _:b523490131 . _:b523490140 . _:b523490141 . _:b523490142 . _:b523490143 . _:b523490140 . _:b523490136 . . _:b523490137 . _:b523490138 . _:b523490139 . _:b523490148 . . _:b523490040 . . _:b523490149 . _:b523490150 . . _:b523490151 . _:b523490144 . _:b523490145 . _:b523490146 . _:b523490147 . _:b523490156 . . _:b523490157 . _:b523490158 . _:b523490159 . _:b523489179 . _:b523490152 . _:b523490153 . _:b523490154 . _:b523490155 . _:b523490164 . . _:b523490165 . _:b523490166 . _:b523490167 . _:b523490160 . _:b523490161 . _:b523489187 . _:b523490162 . _:b523490163 . _:b523490172 . _:b523490173 . _:b523490174 . _:b523490175 . _:b523490168 . _:b523490169 . _:b523490170 . _:b523490171 . _:b523490180 . _:b523490181 . _:b523490182 . . _:b523488876 . _:b523490183 . . _:b523490176 . . _:b523490177 . _:b523490046 . _:b523490178 . _:b523490179 . _:b523490188 . _:b523489544 . _:b523490189 . . _:b523490190 . _:b523490191 . _:b523490184 . _:b523489116 . _:b523490185 . . _:b523490186 . _:b523490187 . _:b523490196 . _:b523490197 . _:b523490198 . _:b523490199 . _:b523490192 . _:b523490193 . _:b523490194 . _:b523489323 . _:b523490195 . _:b523490204 . _:b523490205 . _:b523490206 . _:b523490207 . _:b523490200 . _:b523489060 . _:b523490201 . _:b523490202 . _:b523490203 . _:b523489980 . _:b523490212 . _:b523490213 . _:b523490214 . _:b523490215 . _:b523489879 . _:b523490208 . _:b523490209 . _:b523490210 . _:b523490211 . _:b523490220 . _:b523490221 . _:b523490222 . _:b523490223 . . _:b523490216 . _:b523490217 . . _:b523490218 . _:b523490219 . . _:b523490228 . _:b523490229 . _:b523490230 . . _:b523490231 . _:b523490224 . _:b523489924 . _:b523490225 . _:b523490226 . _:b523490227 . _:b523489608 . . _:b523490028 . _:b523490232 . _:b523490233 . . _:b523489710 . . _:b523490131 . _:b523489428 . . . . . _:b523489949 . . _:b523489665 . _:b22745127 _:b22745144 . . _:b22745127 _:b22745145 . _:b22745127 _:b22745146 . _:b22745127 _:b22745147 . . _:b22745127 _:b22745148 . . _:b523489917 . . _:b22745127 _:b22745136 . _:b523489558 . _:b22745127 _:b22745137 . _:b22745127 _:b22745138 . _:b22745127 _:b22745139 . . _:b523490170 . _:b22745127 _:b22745140 . _:b523489285 "3"^^ . _:b22745127 _:b22745141 . _:b22745127 _:b22745142 . . _:b523490112 . _:b22745127 _:b22745143 . _:b523488819 . _:b22745127 _:b22745128 . _:b523489284 "3"^^ . _:b523489119 . _:b22745127 _:b22745129 . _:b22745127 _:b22745130 . _:b22745127 _:b22745131 . . _:b22745127 _:b22745132 . _:b523489287 "3"^^ . _:b22745127 _:b22745133 . _:b22745127 _:b22745134 . _:b22745127 _:b22745135 . _:b523489286 "3"^^ . _:b523489796 . . _:b523489797 . _:b523489798 . _:b523489799 . _:b523489281 "3"^^ . _:b523489792 . _:b523489793 . _:b523489794 . _:b523489591 . _:b523489795 . _:b523489745 . _:b523489280 "3"^^ . _:b523489804 . _:b523489805 . _:b523489806 . _:b523489807 . _:b523489283 "3"^^ . _:b523489800 . _:b523489801 . _:b523489802 . _:b523489803 . _:b523489282 "3"^^ . _:b523489812 . _:b523489813 . _:b523489814 . _:b523489815 . _:b523489293 "3"^^ . . _:b523489808 . _:b523489809 . . _:b523489810 . _:b523489811 . _:b523489292 "3"^^ . _:b523489820 . _:b523489821 . _:b523489822 . _:b523489823 . _:b523489295 "3"^^ . _:b523489816 . _:b523489817 . _:b523489818 . _:b523489903 . _:b523489819 . _:b523489294 "3"^^ . _:b523489828 . _:b523489829 . _:b523489830 . _:b523489831 . _:b22745148 "2.0)40, as implemented in Gene Pattern>>41<< using a parametric method. To correct for multiple comparisons, we performed a standard Bonferroni correction by setting the threshold of significance equal to 0.05 divided by the number of tests performed under each a priori hypothesis." . _:b523489289 "3"^^ . _:b523489824 . _:b523489825 . . _:b523489826 . _:b523489827 . _:b523489288 "3"^^ . . . _:b523489836 . _:b523489837 . _:b523489838 . _:b523489839 . _:b523489291 "3"^^ . _:b523489832 . _:b523489833 . _:b523489834 . _:b523489835 . _:b523489290 "3"^^ . _:b523488924 . _:b523489456 . _:b523489844 . _:b523489845 . _:b523489846 . _:b523490009 . _:b523489847 . _:b523489301 "3"^^ . _:b523489840 . _:b523489841 . _:b523490145 . _:b523489842 . _:b523489843 . _:b523489300 "3"^^ . _:b523489852 . _:b523489853 . . _:b523489854 . _:b523489855 . _:b523490055 . _:b523490012 . _:b523489303 "3"^^ . _:b523488937 . _:b523489848 . _:b523489849 . _:b523489850 . _:b523489851 . _:b523489302 "3"^^ . _:b523489860 . _:b523489861 . _:b523490091 . _:b523489862 . _:b523489863 . _:b523489297 "3"^^ . _:b523489856 . _:b523489857 . _:b523489858 . _:b523489859 . _:b523489296 "3"^^ . _:b523489868 . _:b523489869 . _:b523488864 . _:b523489870 . _:b523489871 . _:b523489299 "3"^^ . _:b523489864 . _:b523489534 . _:b523489865 . _:b523489866 . _:b523489867 . _:b523489298 "3"^^ . _:b523489876 . _:b523489877 . _:b523489878 . _:b523489879 . _:b523489309 "3"^^ . _:b523489872 . _:b523489873 . _:b523489874 . _:b523488762 . _:b523489875 . _:b523489308 "3"^^ . _:b523489884 . _:b523489885 . _:b523489886 . . _:b523489887 . _:b523489311 "3"^^ . _:b523489880 . _:b523489881 . _:b523489848 . _:b523489882 . . _:b523489883 . _:b523489310 "3"^^ . . _:b523489892 . _:b523489734 . _:b523489893 . _:b523489029 . _:b523489894 . _:b523489895 . _:b523489305 "3"^^ . _:b523489888 . _:b523489889 . _:b523489890 . . _:b523489891 . _:b523489304 "3"^^ . _:b523489900 . _:b523489901 . _:b523489902 . _:b523489903 . _:b523489307 "3"^^ . _:b523489896 . _:b523489897 . _:b523489898 . _:b523490110 . _:b523489899 . _:b523489959 . _:b523489306 "3"^^ . . _:b523489908 . _:b523489909 . _:b523489203 . _:b523489910 . _:b523489911 . . _:b523489317 "3"^^ . . _:b523489904 . _:b523489905 . _:b523489906 . _:b523489907 . _:b523489316 "3"^^ . _:b523489560 . _:b523489916 . _:b523489917 . _:b523489918 . _:b523488820 . _:b523489319 "3"^^ . _:b523489919 . _:b523489912 . _:b523489913 . _:b523489914 . _:b523489915 . _:b523489318 "3"^^ . _:b523489924 . _:b523490089 . _:b523489925 . _:b523488825 . _:b523489926 . _:b523489927 . _:b523489313 "3"^^ . . _:b523489920 . _:b523489921 . . _:b523489922 . _:b523489417 . _:b523489312 "3"^^ . _:b523489923 . . _:b523489932 . _:b523489933 . _:b523489934 . _:b523489935 . _:b523490101 . _:b523489315 "3"^^ . _:b523489928 . _:b523489929 . _:b523489930 . _:b523489931 . _:b523489314 "3"^^ . _:b523489940 . _:b523489941 . _:b523489942 . _:b523489943 . _:b523489325 "3"^^ . _:b523489936 . _:b523489765 . _:b523489937 . _:b523489938 . . _:b523489939 . _:b523489324 "3"^^ . _:b523489948 . _:b523489949 . _:b523489950 . _:b523489920 . _:b523489461 . _:b523489327 "3"^^ . _:b523489951 . _:b523489944 . _:b523489945 . _:b523489006 . _:b523489946 . _:b523489947 . _:b523489326 "3"^^ . _:b523489956 . _:b523489957 . _:b523489958 . _:b523489959 . _:b523489321 "3"^^ . _:b523489952 . _:b523489953 . _:b523489954 . _:b523489955 . _:b523489320 "3"^^ . _:b523489964 . _:b523489176 . _:b523489965 . _:b523489966 . _:b523489967 . _:b523489323 "3"^^ . _:b523489960 . _:b523489961 . _:b523489962 . _:b523489463 . _:b523489322 "3"^^ . _:b523489963 . _:b523489972 . . _:b523489973 . _:b523489974 . _:b523489975 . _:b523489333 "3"^^ . . _:b523489968 . _:b523490129 . _:b523489936 . _:b523488878 . _:b523489969 . _:b523489170 . _:b523489970 . _:b523489971 . _:b523489332 "3"^^ . _:b523489980 . _:b523489981 . . . _:b523489982 . _:b523489983 . _:b523489335 "3"^^ . . _:b523489983 . _:b523489976 . . _:b523489977 . _:b523489978 . . _:b523489979 . _:b523489334 "3"^^ . _:b523489988 . . _:b523489989 . . _:b523489990 . _:b523489991 . _:b523489329 "3"^^ . _:b523489984 . _:b523489985 . _:b523489986 . _:b523489987 . _:b523489328 "3"^^ . _:b523489996 . _:b523489997 . _:b523489998 . _:b523489999 . _:b523489331 "3"^^ . _:b523489992 . _:b523489993 . _:b523489994 . _:b523489995 . _:b523489330 "3"^^ . _:b523490004 . . _:b523490005 . _:b523490006 . _:b523490007 . _:b523489341 "3"^^ . _:b523490000 . _:b523489887 . _:b523490001 . _:b523490002 . _:b523490003 . _:b523489340 "3"^^ . _:b523490012 . . _:b523490013 . _:b523490014 . _:b523490015 . _:b523489343 "3"^^ . _:b523490008 . _:b523490009 . _:b523490010 . _:b523490011 . _:b523489342 "3"^^ . . _:b523490020 . _:b523490106 . . _:b523490021 . _:b523490022 . _:b523490023 . _:b523489337 "3"^^ . _:b523490016 . _:b523489934 . _:b523489860 . _:b523490017 . _:b523490018 . _:b523490019 . _:b523489336 "3"^^ . _:b523489101 . . _:b523490028 . . _:b523490029 . _:b523490030 . _:b523489873 . _:b523489429 . _:b523490031 . _:b523489339 "3"^^ . _:b523490024 . _:b523490025 . _:b523490026 . _:b523490027 . _:b523489338 "3"^^ . _:b523490036 . _:b523488952 . _:b523490037 . _:b523490038 . . _:b523490039 . _:b523490127 . _:b523489349 "3"^^ . _:b523489594 . _:b523490032 . _:b523490033 . _:b523490034 . _:b523490035 . _:b523489348 "3"^^ . _:b523490044 . _:b523490045 . _:b523490046 . _:b523490047 . _:b523489351 "3"^^ . _:b523490040 . _:b523490041 . _:b523490042 . _:b523488869 . _:b22745131 "All subjects had a global Clinical Dementia Rating scale>>21<< (CDR) score = 0, 0.5 or 1." . _:b523489350 "3"^^ . _:b523490043 . . _:b523489540 . _:b523489541 . _:b523489542 . . _:b523489543 . _:b523489345 "3"^^ . _:b523489536 . _:b22745138 . _:b523489537 . _:b523489538 . _:b523489446 . _:b523489344 "3"^^ . _:b523489539 . _:b523489098 . _:b523489548 . _:b523489549 . . _:b523489550 . _:b523489551 . _:b523489347 "3"^^ . _:b523489544 . _:b523490020 . _:b523489545 . _:b523489546 . _:b523489547 . _:b523489346 "3"^^ . _:b523489556 . _:b22745137 . _:b523489557 . _:b523489558 . _:b523489357 "2"^^ . _:b523489559 . _:b523489552 . _:b523489553 . _:b523489422 . _:b523489554 . _:b523489356 "2"^^ . _:b523489555 . _:b523489564 . _:b523489245 . _:b523489565 . _:b523489566 . _:b523489359 "2"^^ . _:b523489567 . _:b523489560 . _:b523489561 . . _:b523489358 "2"^^ . _:b523489562 . _:b523488794 . _:b523489563 . . _:b523489572 . _:b523489573 . _:b523489574 . _:b523489353 "2"^^ . . _:b523489575 . _:b523489568 . _:b523489569 . _:b523489570 . _:b523489571 . _:b523489352 "3"^^ . _:b523489580 . _:b523489581 . _:b523490033 . _:b523489582 . _:b523489355 "2"^^ . _:b523489583 . _:b523490179 . . _:b523489576 . _:b523489785 . _:b523489577 . _:b523489578 . _:b523489354 "2"^^ . _:b523489579 . _:b523489588 . _:b523489589 . _:b22745141 . _:b523489590 . _:b523489365 "2"^^ . _:b523489591 . _:b523489584 . _:b22745134 . _:b523489585 . _:b523489586 . _:b523489364 "2"^^ . _:b523488917 . _:b523489587 . _:b523489596 . _:b22745135 . _:b523489597 . . _:b523489598 . _:b523489367 "2"^^ . _:b523489599 . _:b523489592 . _:b523489593 . _:b22745144 . _:b523489594 . _:b523489366 "2"^^ . _:b523489595 . _:b523489604 . _:b523489605 . _:b523489606 . _:b523489361 "2"^^ . _:b523489607 . _:b523489600 . _:b523489601 . _:b523489602 . _:b523489360 "2"^^ . _:b523489603 . _:b523489612 . _:b523489613 . _:b523489614 . _:b523489363 "2"^^ . _:b523489615 . _:b523489608 . _:b523489609 . _:b523489610 . _:b523489362 "2"^^ . _:b523489611 . _:b523489620 . _:b523489621 . _:b523489679 . . _:b523489373 "2"^^ . _:b523489622 . _:b523489623 . _:b523489704 . _:b523489835 . _:b523489616 . _:b523489617 . _:b523490174 . . _:b523489372 "2"^^ . _:b523489618 . . _:b523489857 . _:b523489619 . _:b523489628 . _:b523489629 . _:b523489630 . _:b523489375 "2"^^ . _:b523489631 . _:b523489624 . _:b523489625 . _:b523489626 . _:b523489374 "2"^^ . _:b523489627 . _:b523489636 . _:b523489637 . _:b523489638 . _:b523489369 "2"^^ . _:b523489639 . _:b523489632 . _:b523489633 . _:b523489634 . _:b523489368 "2"^^ . _:b523489635 . _:b523490141 . _:b523489644 . _:b523489645 . _:b523489646 . _:b523489371 "2"^^ . _:b523489647 . _:b523489640 . _:b523489641 . . _:b523489370 "2"^^ . _:b523489642 . _:b523489643 . . _:b523489652 . _:b523489653 . _:b523489654 . . _:b523489381 "2"^^ . _:b523489655 . _:b523489648 . _:b523489649 . _:b523489249 . _:b523489380 "2"^^ . _:b523489650 . . . _:b523489651 . _:b523489660 . . . _:b523489661 . _:b523489662 . _:b523489383 "2"^^ . _:b523489663 . . _:b523489656 . _:b523488899 . _:b523489657 . _:b523489658 . _:b523489382 "2"^^ . _:b523489659 . _:b523490066 . _:b523489668 . _:b523489669 . . _:b523489670 . _:b523489377 "2"^^ . _:b523488849 . _:b523489671 . _:b523489664 . _:b523489665 . _:b523489849 . _:b523489666 . _:b523489376 "2"^^ . _:b523488939 . . _:b523489667 . . _:b523489676 . _:b523489677 . _:b523489678 . _:b523489379 "2"^^ . _:b523489679 . . _:b523489672 . _:b523489673 . _:b523489674 . _:b523489378 "2"^^ . _:b523489675 . . _:b523489684 . _:b523489685 . _:b523489686 . _:b523489389 "2"^^ . _:b523489687 . _:b523490097 . _:b523489680 . _:b523489958 . _:b523489681 . _:b523489682 . _:b523489388 "2"^^ . _:b523489683 . _:b523489692 . _:b523489693 . _:b523489694 . _:b523489391 "2"^^ . _:b523489695 . . _:b523489688 . _:b523489689 . . _:b523489390 "2"^^ . _:b523489690 . _:b523489691 . _:b523489700 . _:b523489701 . _:b523489814 . _:b523489702 . _:b523489385 "2"^^ . _:b523489703 . _:b523489477 . _:b523489696 . _:b523489697 . _:b523490182 . _:b523489698 . _:b523489384 "2"^^ . _:b523488993 . _:b523489699 . _:b523488927 . _:b523489708 . . _:b523489709 . _:b523489710 . _:b523489387 "2"^^ . _:b523489711 . _:b523489704 . _:b523489715 . _:b523489705 . _:b523489706 . _:b523489386 "2"^^ . _:b523489707 . _:b523489354 . _:b523489716 . _:b523489717 . _:b523489718 . _:b523489397 "2"^^ . _:b523489719 . _:b523489712 . _:b22745132 "The QC process included a principal components analysis using default parameters in EIGENSTRAT>>25<< to identify and remove population outliers." . _:b523489713 . _:b523489714 . _:b523489396 "2"^^ . _:b523489715 . _:b523489724 . _:b523489725 . _:b523489726 . _:b523489399 "2"^^ . _:b523489727 . . . _:b523489720 . _:b523489721 . _:b523489722 . _:b523489398 "2"^^ . _:b523489723 . _:b523489732 . . _:b523489733 . _:b523489734 . _:b523489393 "2"^^ . . _:b523489735 . _:b523489728 . _:b523489979 . _:b523489729 . _:b523489730 . _:b523489392 "2"^^ . . _:b523489731 . _:b523489740 . _:b523489741 . . _:b523489742 . _:b523489395 "2"^^ . _:b523489743 . . _:b523489736 . . _:b523489737 . _:b523489738 . _:b523489394 "2"^^ . _:b523489180 . _:b523489739 . _:b523489748 . _:b523489749 . _:b523489750 . _:b523489405 "2"^^ . _:b523489751 . _:b523489744 . _:b523489745 . _:b523489746 . _:b523489404 "2"^^ . . _:b523489747 . _:b523489756 . _:b523489757 . . . _:b523489407 "2"^^ . . _:b523489758 . _:b523489759 . _:b523489752 . . _:b523489753 . _:b523489033 . _:b523489754 . _:b523489406 "2"^^ . _:b523489755 . _:b523489764 . _:b523489657 . _:b523489765 . _:b523489766 . _:b523489401 "2"^^ . _:b523489767 . _:b523489760 . _:b523489640 . _:b523489761 . _:b523489762 . _:b523489400 "2"^^ . _:b523489763 . _:b523489772 . _:b523489773 . _:b523489774 . _:b523489403 "2"^^ . _:b523489775 . _:b523489722 . _:b523489720 . _:b523489768 . _:b523489769 . . _:b523489113 . _:b523489402 "2"^^ . _:b523489770 . _:b523489771 . _:b523489372 . _:b523489780 . _:b523489781 . _:b523489782 . _:b523489413 "2"^^ . _:b523489783 . _:b523489420 . _:b523489776 . . _:b523489777 . _:b523489778 . _:b523489412 "2"^^ . _:b523489779 . _:b523488837 . _:b523489788 . _:b523489789 . _:b523489790 . _:b523489415 "2"^^ . _:b523489791 . . . _:b523489784 . . _:b523489785 . _:b523489786 . _:b523489414 "2"^^ . _:b523489787 . _:b523489284 . _:b523489285 . _:b523489286 . _:b523489409 "2"^^ . _:b523489287 . _:b523489280 . _:b523489281 . . _:b523489408 "2"^^ . _:b523489282 . _:b523489283 . _:b523489292 . _:b523489460 . _:b523489293 . _:b523489294 . _:b523489411 "2"^^ . _:b523489295 . _:b523489288 . _:b523489418 . _:b523489289 . _:b523489290 . _:b523489410 "2"^^ . _:b523489291 . _:b523489300 . _:b523489301 . . _:b523489302 . _:b523489421 "2"^^ . _:b523489303 . _:b523489296 . _:b523489297 . _:b523489243 . _:b523489298 . _:b523489420 "2"^^ . _:b523489299 . _:b523489308 . . _:b523489228 . _:b523489309 . _:b523489310 . _:b523489423 "2"^^ . _:b523489311 . _:b523489304 . _:b523489305 . _:b523489306 . _:b523489422 "2"^^ . _:b523489528 . _:b523489307 . _:b523489316 . _:b523489317 . _:b523489318 . _:b523490098 . _:b523489417 "2"^^ . _:b523489319 . . _:b523489312 . _:b523489069 . _:b523489313 . _:b523489314 . _:b523489416 "2"^^ . _:b523489315 . _:b523490215 . _:b523489324 . _:b22745127 . _:b523490210 . _:b523489325 . _:b523489326 . _:b523489419 "2"^^ . _:b523489327 . _:b523489813 . _:b523489320 . _:b523489321 . _:b523489322 . _:b523489418 "2"^^ . _:b523489323 . . _:b523489332 . _:b523489333 . _:b523489334 . _:b523489429 "2"^^ . _:b523489335 . _:b523490011 . _:b523489328 . _:b523489329 . _:b523489330 . _:b523489428 "2"^^ . _:b523489331 . _:b523489340 . _:b523489341 . _:b523488997 . _:b523489431 "2"^^ . _:b523489342 . . _:b523489343 . _:b523489336 . _:b523489685 . _:b523489337 . _:b523489338 . _:b523489430 "2"^^ . _:b523488938 . . _:b523489339 . _:b523489348 . _:b523489349 . _:b523489350 . _:b523489425 "2"^^ . . _:b523489351 . _:b523489344 . _:b523489345 . _:b523489346 . _:b523489424 "2"^^ . _:b523489347 . _:b523489356 . . _:b523489357 . . _:b523489427 "2"^^ . _:b523489358 . _:b523489359 . _:b523489748 . _:b523489352 . _:b523489353 . _:b523489354 . _:b523489426 "2"^^ . _:b523489355 . _:b523489743 . _:b523489364 . _:b523489365 . _:b523489366 . _:b523489437 "2"^^ . _:b523489367 . _:b523489360 . _:b523489361 . _:b523489649 . _:b523489436 "2"^^ . _:b523489362 . _:b523489363 . _:b523489372 . _:b523489373 . _:b523489374 . _:b523489439 "2"^^ . _:b523489375 . _:b523489368 . _:b523489369 . _:b523489042 . . _:b523489438 "2"^^ . _:b523489370 . _:b523489371 . _:b523489380 . _:b523489381 . _:b523489382 . _:b523489433 "2"^^ . _:b523489383 . _:b523489376 . _:b523489377 . _:b523489378 . _:b523489432 "2"^^ . _:b523489379 . _:b523489388 . _:b523489389 . _:b523489390 . _:b523489435 "2"^^ . _:b523489391 . _:b523489384 . _:b523489385 . _:b523489386 . _:b523489434 "2"^^ . _:b523489387 . _:b523489396 . _:b523489397 . _:b523489398 . _:b523489445 "2"^^ . _:b523489399 . _:b523489770 . _:b523489392 . _:b523489393 . _:b523489995 . _:b523489394 . _:b523489444 "2"^^ . _:b523489395 . _:b523489404 . _:b523489405 . . _:b523489406 . _:b523489447 "2"^^ . _:b523489407 . _:b523489400 . . _:b523489401 . _:b523489402 . _:b523489446 "2"^^ . _:b523489403 . _:b523489412 . _:b523489413 . _:b523489414 . _:b523489441 "2"^^ . _:b523489415 . _:b523489408 . _:b523489409 . _:b523489410 . _:b523489440 "2"^^ . . . _:b523489411 . _:b523489420 . _:b523489421 . . _:b523489422 . _:b523489443 "2"^^ . _:b523489423 . _:b523489416 . _:b523489417 . _:b523489418 . _:b523489442 "2"^^ . _:b523489419 . _:b523489428 . . _:b523489429 . _:b523489430 . _:b523489453 "2"^^ . _:b523489431 . _:b523489424 . _:b523489425 . _:b523489426 . _:b523489452 "2"^^ . _:b523489427 . _:b523489436 . _:b523489437 . _:b523489438 . _:b523489455 "2"^^ . _:b523489439 . _:b523489432 . _:b523489433 . _:b523489913 . _:b523489434 . _:b523489454 "2"^^ . _:b523489435 . _:b523489444 . _:b523489445 . . _:b523489449 "2"^^ . _:b523489446 . _:b523489447 . _:b523489440 . _:b523489441 . _:b523489967 . . _:b523489448 "2"^^ . _:b523489650 . _:b523489442 . _:b523489443 . _:b523490137 . . _:b523489452 . _:b523489453 . _:b523489454 . _:b523489451 "2"^^ . _:b523489455 . _:b523489448 . _:b523489449 . _:b523489450 . _:b523489886 . _:b523489450 "2"^^ . _:b523489451 . _:b523489703 . _:b523489460 . _:b523489461 . _:b523489462 . _:b523489461 "2"^^ . _:b523489463 . _:b523489456 . _:b523489457 . _:b523489458 . _:b523489460 "2"^^ . _:b523489459 . _:b523489468 . _:b523488792 . _:b523489469 . _:b523489470 . _:b523489463 "2"^^ . _:b523489471 . _:b523489464 . _:b523489465 . _:b523489466 . _:b523489462 "2"^^ . . _:b523489467 . _:b523489476 . _:b523489948 . _:b523489477 . . . _:b523489457 "2"^^ . _:b523489478 . _:b523489479 . _:b523488766 . _:b523489472 . _:b523489473 . _:b523489474 . _:b523489456 "2"^^ . _:b523489475 . _:b523489484 . _:b523489485 . _:b523489486 . _:b523489459 "2"^^ . _:b523489487 . . _:b523489480 . _:b523489481 . _:b523489482 . _:b523489458 "2"^^ . _:b523489357 . _:b523489483 . _:b523489492 . _:b523489493 . _:b523489494 . _:b523489469 "2"^^ . _:b523489495 . _:b523489488 . _:b523489489 . . _:b523489468 "2"^^ . _:b523489490 . _:b523489491 . _:b523489500 . _:b523489501 . . _:b523489471 "2"^^ . _:b523489502 . _:b523489503 . _:b523489496 . _:b523489497 . _:b523489498 . _:b523489470 "2"^^ . _:b523489499 . _:b523489508 . _:b523489509 . _:b523489510 . _:b523489465 "2"^^ . _:b523489511 . _:b523489504 . . _:b523488758 . _:b523489505 . _:b523489506 . _:b523489464 "2"^^ . . _:b523489507 . _:b523489516 . _:b523489517 . _:b523489583 . _:b523489467 "2"^^ . _:b523489518 . _:b523489519 . _:b523489512 . _:b523490204 . _:b523489513 . _:b523489514 . _:b523489466 "2"^^ . _:b523489515 . _:b523489524 . _:b523489525 . _:b523489526 . . _:b523489477 "2"^^ . . _:b523489527 . _:b523489520 . _:b523489521 . . _:b523489476 "2"^^ . _:b523489522 . _:b523489523 . _:b523489532 . _:b523490226 . . _:b523489533 . _:b523489534 . _:b523489479 "2"^^ . _:b523489535 . _:b523489528 . _:b523489529 . _:b523489530 . _:b523489478 "2"^^ . _:b523489531 . _:b523489355 . . . _:b523489473 "2"^^ . _:b523489472 "2"^^ . _:b22745144 "PiB retention in the FLR region is substantial in patients with diagnosed AD and has been used as a summary measure of PiB retention in previous studies>>33<<, 34, 39. 1.25 is the value used to separate PiB+ and PiB\u2212 in the HAB cohort, and 1.5 is used to delineate between PiB+ and PiB\u2212 in the ADNI cohort." . _:b523489475 "2"^^ . . _:b523489474 "2"^^ . _:b523489485 "2"^^ . . _:b523490058 . . _:b523489484 "2"^^ . . _:b523489599 . _:b523489487 "2"^^ . _:b523488802 . _:b523489486 "2"^^ . _:b523489301 . _:b523489950 . _:b523489481 "2"^^ . . _:b523489864 . _:b523489480 "2"^^ . _:b523489483 "2"^^ . . _:b523489482 "2"^^ . . _:b523489493 "2"^^ . . _:b523489673 . _:b523489492 "2"^^ . . . _:b523489495 "2"^^ . . . _:b523489494 "2"^^ . _:b523489730 . _:b523489489 "2"^^ . _:b523489606 . _:b523489488 "2"^^ . . . _:b523489491 "2"^^ . _:b523488832 . _:b523489490 "2"^^ . _:b523490219 . . _:b523489501 "2"^^ . _:b523489844 . _:b523489500 "2"^^ . . _:b523489503 "2"^^ . _:b523489507 . _:b523489502 "2"^^ . . _:b523489497 "2"^^ . . _:b523490222 . _:b523489057 . _:b523489496 "2"^^ . _:b523489499 "2"^^ . _:b523490006 . . _:b523489498 "2"^^ . _:b523489509 "2"^^ . _:b523490068 . _:b523489169 . _:b523489508 "2"^^ . _:b523489038 . _:b523489511 "2"^^ . . _:b523489510 "2"^^ . _:b523489505 "2"^^ . _:b523488919 . _:b523488909 . _:b523489504 "2"^^ . . _:b523489507 "2"^^ . _:b523489506 "2"^^ . _:b523488892 . _:b523489517 "2"^^ . _:b523489542 . . _:b523489573 . . _:b523490021 . _:b523489516 "2"^^ . _:b523489806 . . . _:b523489519 "2"^^ . . . _:b523489940 . _:b523489518 "2"^^ . _:b22745135 "6 micron sections were used to visualize neuritic plaques, diffuse plaques, and neurofibrillary tangles in the frontal, temporal, parietal, entorhinal, and hippocampal cortices, as previously described, for the pathologic diagnosis of AD>>29<<. A neuropathologic diagnosis of \u201Cno AD,\u201D \u201Clow likelihood AD,\u201D \u201Cintermediate likelihood AD,\u201D or \u201Chigh likelihood AD\u201D was given based on semiquantitative estimates of neuritic plaque density as recommended by CERAD and the neurofibrillary" . . _:b523489513 "2"^^ . _:b523489910 . _:b523489512 "2"^^ . _:b523489740 . _:b523489515 "2"^^ . _:b523489331 . _:b523489514 "2"^^ . _:b523490109 . _:b523489525 "2"^^ . . _:b523489524 "2"^^ . _:b523489476 . _:b523489527 "2"^^ . . _:b523489526 "2"^^ . . . _:b523489521 "2"^^ . _:b523490173 . _:b523489520 "2"^^ . _:b523490090 . _:b523489523 "2"^^ . _:b523489522 "2"^^ . _:b523489774 . _:b22745129 . . _:b523489533 "2"^^ . . _:b22745133 "We tested monocyte uptake ability in circulating monocytes using two different substrates that have been deployed previously in this experimental paradigm>>26<<. After thawing, PBMCs were washed in 10 ml PBS." . _:b523489532 "2"^^ . . . _:b523489535 "2"^^ . _:b523489749 . _:b523488800 . _:b523489534 "2"^^ . _:b523489529 "2"^^ . _:b22745128 . _:b523489511 . _:b523489528 "2"^^ . _:b523489531 "2"^^ . _:b523490132 . _:b523489530 "2"^^ . . _:b22745131 . _:b523489541 "2"^^ . . _:b523488934 . _:b523489540 "2"^^ . _:b523489543 "2"^^ . _:b523489270 . _:b523489542 "2"^^ . _:b523489537 "2"^^ . _:b523489509 . _:b523489858 . _:b523489536 "2"^^ . _:b523490183 . _:b523489539 "2"^^ . _:b523488882 . _:b523489538 "2"^^ . . _:b523489549 "2"^^ . . _:b523489548 "2"^^ . _:b523489193 . _:b523489551 "2"^^ . _:b523489550 "2"^^ . _:b523489545 "2"^^ . _:b523489227 . . _:b523489544 "2"^^ . . _:b523489547 "2"^^ . _:b523489546 "2"^^ . . _:b523489557 "2"^^ . _:b523489164 . _:b523489556 "2"^^ . _:b523488749 . _:b523489909 . _:b523489559 "2"^^ . _:b523489517 . _:b523489558 "2"^^ . _:b523488940 . . _:b523489664 . _:b523489553 "2"^^ . . . _:b523489552 "2"^^ . . _:b523489204 . _:b523488750 . _:b523489555 "2"^^ . _:b523489554 "2"^^ . _:b523489612 . _:b523489565 "2"^^ . _:b523489096 . . _:b523489564 "2"^^ . _:b523489863 . _:b523489567 "2"^^ . . _:b523489566 "2"^^ . _:b523490216 . _:b523489561 "2"^^ . . _:b523489560 "2"^^ . . . _:b523489563 "2"^^ . _:b523489562 "2"^^ . . _:b22745128 "All participants had a Clinical Dementia Rating of >>021<<, performed no worse than 1.5 SD units below the age- and education-corrected norm on the Logical Memory IIa subtest of the Wechsler Memory Scale-Revised22, and scored 26 or above on the Mini-Mental State Examination23." . _:b523489573 "2"^^ . . . . _:b523489572 "2"^^ . _:b523489914 . _:b523489575 "2"^^ . _:b523489574 "2"^^ . _:b523489569 "2"^^ . . _:b523490093 . _:b523489568 "2"^^ . _:b523489571 "2"^^ . _:b523488980 . _:b523489570 "2"^^ . _:b523489011 . . _:b523489488 . _:b523489581 "2"^^ . . _:b523489746 . _:b523489580 "2"^^ . _:b523489583 "2"^^ . _:b523489588 . _:b523489582 "2"^^ . . _:b523489577 "2"^^ . . _:b523489576 "2"^^ . _:b523488989 . _:b523489300 . _:b523489579 "2"^^ . _:b523489578 "2"^^ . _:b523489589 "2"^^ . _:b523489588 "2"^^ . _:b523489591 "2"^^ . _:b523489449 . _:b523489930 . . _:b523489590 "2"^^ . _:b523489585 "2"^^ . _:b523488865 . _:b523489826 . _:b523489584 "2"^^ . _:b523489587 "2"^^ . . _:b523489846 . _:b523489586 "2"^^ . _:b523489597 "2"^^ . . _:b523490177 . _:b523489596 "2"^^ . _:b523489599 "2"^^ . _:b523489598 "2"^^ . _:b523489356 . . _:b523488831 . _:b523490078 . _:b523489593 "2"^^ . _:b523488797 . . _:b523490166 . _:b523489592 "2"^^ . _:b523489595 "2"^^ . _:b523488771 . _:b523489594 "2"^^ . _:b523489605 "2"^^ . _:b523490031 . _:b523489288 . . _:b523489659 . _:b523489604 "2"^^ . . _:b523489358 . _:b523489607 "2"^^ . _:b523489027 . _:b523489631 . . _:b523489606 "2"^^ . . _:b523489601 "2"^^ . _:b523490052 . _:b523489600 "2"^^ . _:b523489348 . _:b523489603 "2"^^ . . _:b523489590 . _:b523489454 . _:b523489602 "2"^^ . . _:b523489281 . _:b523489613 "2"^^ . _:b523489612 "2"^^ . _:b523489615 "2"^^ . . _:b523489752 . _:b523489614 "2"^^ . _:b523489609 "2"^^ . _:b523488839 . _:b523489739 . _:b523489608 "2"^^ . _:b523490087 . _:b523489611 "2"^^ . _:b523489847 . _:b523490189 . _:b523489610 "2"^^ . . _:b523489621 "2"^^ . . _:b523489620 "2"^^ . . _:b523489524 . _:b523489157 . _:b523489623 "2"^^ . _:b523489289 . . . _:b523489622 "2"^^ . _:b523489617 "2"^^ . _:b523489165 . . _:b523489616 "2"^^ . _:b523489148 . . . _:b523489619 "2"^^ . _:b523488801 . _:b523489618 "2"^^ . . _:b523489629 "2"^^ . _:b523489628 "2"^^ . . _:b523489631 "2"^^ . _:b523489823 . _:b523489992 . _:b523489630 "2"^^ . _:b523489625 "2"^^ . _:b523488965 . . _:b523489624 "2"^^ . . . _:b523489627 "2"^^ . . _:b523489626 "2"^^ . _:b523489637 "2"^^ . . . _:b523489334 . . _:b523489636 "2"^^ . _:b523489989 . _:b523489639 "2"^^ . _:b523489638 "2"^^ . . _:b523489633 "2"^^ . _:b523489632 "2"^^ . _:b22745127 . _:b523488798 . _:b523489635 "2"^^ . . _:b523489634 "2"^^ . _:b523489645 "2"^^ . . . . _:b523489644 "2"^^ . _:b523489647 "2"^^ . _:b523488862 . _:b22745132 . _:b523489646 "2"^^ . _:b523489438 . _:b22745133 . _:b523489641 "2"^^ . _:b22745134 . . _:b523489253 . _:b523489640 "2"^^ . _:b22745135 . _:b523489643 "2"^^ . _:b523489672 . _:b22745128 . _:b523489642 "2"^^ . . _:b22745129 . _:b523489653 "2"^^ . _:b22745130 . _:b523489652 "2"^^ . _:b22745131 . _:b523489655 "2"^^ . _:b22745140 . _:b523489335 . _:b523490188 . _:b523489282 . _:b523489762 . _:b523489324 . _:b523489654 "2"^^ . _:b22745141 . _:b523489997 . . _:b523488883 . _:b523489649 "2"^^ . _:b22745142 . _:b523490073 . _:b523489648 "2"^^ . _:b523490203 . _:b22745143 . . _:b523489651 "2"^^ . . _:b22745136 . _:b523489650 "2"^^ . _:b523489568 . _:b22745137 . _:b523489661 "2"^^ . . _:b22745138 . . . _:b523489219 . _:b523489660 "2"^^ . . . _:b22745139 . _:b22745136 "AD\u201D was given based on semiquantitative estimates of neuritic plaque density as recommended by CERAD and the neurofibrillary tangle stage by Braak and Braak as recommended by the National Institute on Aging (NIA) - Reagan criteria>>30<<. For analyses, the neuropathologic diagnosis of AD was considered absent if NIA-Reagan diagnosis was no or low and present if intermediate or high likelihood29." . _:b523489455 . _:b523489663 "2"^^ . _:b22745148 . . _:b523489866 . _:b523489662 "2"^^ . . . . _:b523489657 "2"^^ . _:b523489759 . _:b523489656 "2"^^ . . _:b523489659 "2"^^ . _:b523489572 . _:b22745144 . . _:b523489380 . _:b523489658 "2"^^ . _:b22745145 . _:b523488818 . . _:b523489669 "2"^^ . . _:b22745146 . _:b523489056 . _:b523489668 "2"^^ . _:b523489291 . _:b22745147 . _:b523489671 "2"^^ . _:b523489670 "2"^^ . _:b523489286 . _:b523489700 . _:b523489280 . _:b523489665 "2"^^ . _:b523489664 "2"^^ . _:b523489580 . _:b523489667 "2"^^ . . _:b523489276 . _:b523490139 . . _:b523489987 . _:b523489666 "2"^^ . _:b523489736 . _:b523489677 "2"^^ . _:b523489676 "2"^^ . _:b523489386 . _:b523489679 "2"^^ . _:b523489678 "2"^^ . . _:b523489673 "2"^^ . . _:b523489827 . _:b523489672 "2"^^ . _:b523488757 . _:b523489675 "2"^^ . _:b523489705 . . _:b523489674 "2"^^ . . _:b523489685 "2"^^ . _:b523489465 . _:b523489692 . _:b523489684 "2"^^ . _:b523489497 . _:b523490192 . _:b523489687 "2"^^ . _:b22745136 . _:b523489686 "2"^^ . . _:b523489681 "2"^^ . _:b523489150 . _:b523489680 "2"^^ . . _:b523489918 . _:b523489683 "2"^^ . . _:b523489682 "2"^^ . . _:b523489693 "2"^^ . . _:b523489692 "2"^^ . _:b523489695 "2"^^ . _:b523490107 . . . _:b523489694 "2"^^ . . . _:b523489689 "2"^^ . _:b523489688 "2"^^ . _:b523489691 "2"^^ . _:b523489690 "2"^^ . . . _:b523489701 "2"^^ . . . _:b523489700 "2"^^ . _:b523489347 . _:b523489703 "2"^^ . _:b523489702 "2"^^ . _:b523489697 "2"^^ . _:b523489337 . _:b523489696 "2"^^ . _:b523489699 "2"^^ . _:b523489698 "2"^^ . _:b523489546 . _:b523489709 "2"^^ . . _:b523489708 "2"^^ . . _:b523489916 . _:b523489711 "2"^^ . . _:b523489710 "2"^^ . _:b523490000 . _:b523489965 . _:b523489705 "2"^^ . _:b523489704 "2"^^ . _:b523488804 . _:b523489707 "2"^^ . _:b523489998 . . _:b523489800 . . _:b523489706 "2"^^ . . _:b523489717 "2"^^ . _:b523490049 . _:b523489716 "2"^^ . _:b523489926 . _:b523489001 . _:b523489719 "2"^^ . . _:b523489054 . _:b523488782 . _:b523489389 . _:b523489718 "2"^^ . . _:b523489399 . _:b523489713 "2"^^ . _:b523489712 "2"^^ . _:b523489790 . _:b523489715 "2"^^ . . . _:b523489714 "2"^^ . _:b523489725 "2"^^ . _:b523488880 . _:b523489396 . _:b523489724 "2"^^ . . _:b523489727 "2"^^ . _:b523489726 "2"^^ . . _:b523489721 "2"^^ . . _:b523488911 . _:b523489720 "2"^^ . _:b523489547 . _:b523489723 "2"^^ . . _:b523489722 "2"^^ . _:b523489733 "2"^^ . _:b523489732 "2"^^ . . _:b523489120 . _:b523489735 "2"^^ . . _:b523489734 "2"^^ . _:b523489040 . . . _:b523490130 . _:b523489186 . _:b523490022 . _:b523489729 "2"^^ . . _:b523489728 "2"^^ . _:b523489731 "2"^^ . _:b523489946 . _:b523489730 "2"^^ . . _:b523489145 . _:b523489741 "2"^^ . . _:b523489740 "2"^^ . . _:b523489490 . _:b523489743 "2"^^ . _:b523489742 "2"^^ . . _:b523489737 "2"^^ . _:b523488764 . _:b523489736 "2"^^ . _:b523489453 . . _:b523489739 "2"^^ . _:b523489728 . . _:b523489738 "2"^^ . _:b523489749 "2"^^ . _:b523488789 . _:b523489041 . _:b523489748 "2"^^ . _:b523489751 "2"^^ . _:b523488867 . _:b523489376 . _:b523489750 "2"^^ . . _:b523489745 "2"^^ . _:b523489744 "2"^^ . _:b523489747 "2"^^ . . _:b523489746 "2"^^ . _:b523489757 "2"^^ . _:b523489756 "2"^^ . _:b523489759 "2"^^ . . _:b523489758 "2"^^ . . _:b523489753 "2"^^ . _:b523489467 . _:b523489752 "2"^^ . . . _:b523489755 "2"^^ . _:b523488786 . _:b523489754 "2"^^ . _:b523489714 . _:b523489741 . _:b523489765 "2"^^ . _:b523489764 "2"^^ . . . _:b523489767 "2"^^ . . _:b523489766 "2"^^ . _:b523488754 . . _:b523489761 "2"^^ . . _:b523489760 "2"^^ . . . _:b523489763 "2"^^ . _:b523488879 . . _:b523489762 "2"^^ . . . _:b523489773 "2"^^ . . _:b523489772 "2"^^ . _:b523489775 "2"^^ . . . _:b523489774 "2"^^ . . . . _:b523489769 "2"^^ . _:b523490030 . _:b523489269 . _:b523488868 . _:b523489768 "2"^^ . . _:b523489771 "2"^^ . _:b523489888 . _:b523488905 . _:b523489770 "2"^^ . _:b523489781 "2"^^ . . _:b523489780 "2"^^ . . _:b523490161 . . _:b523489783 "2"^^ . _:b523488942 . _:b523489782 "2"^^ . . _:b523490190 . . _:b523489777 "2"^^ . _:b523489471 . _:b523489776 "2"^^ . _:b523489779 "2"^^ . _:b523489527 . _:b523489778 "2"^^ . . _:b523489789 "2"^^ . _:b523489788 "2"^^ . _:b523489729 . _:b523489791 "2"^^ . . _:b523489790 "2"^^ . . _:b523489956 . . . _:b523489785 "2"^^ . . . _:b523489784 "2"^^ . _:b523490156 . . _:b523489787 "2"^^ . _:b523489201 . . _:b523489786 "2"^^ . . . _:b523489263 . _:b523489695 . . . _:b523489173 . . . . _:b523489138 . _:b523490019 . _:b523488871 . _:b523489929 . . . _:b523489581 . _:b523489423 . . _:b523489371 . _:b523490100 . _:b523489160 . _:b523488887 . _:b523489226 . _:b523489922 . _:b523489230 . . . . _:b523489586 . . . . _:b523489872 . _:b523489018 . _:b523489639 . _:b523489409 . _:b523489723 . . _:b523489941 . . _:b523488828 . _:b523489859 . . _:b523489644 . . _:b523489003 . . . . . . _:b523490083 . _:b22745134 . _:b523488958 . . . . . _:b523489479 . . . . . . _:b523488765 . . . . _:b523488834 . _:b523489039 . . . _:b523489360 . . _:b523489875 . . _:b523489990 . . _:b523489052 . . . . _:b523488954 . . _:b523489716 . . . _:b523489520 . . . . _:b523489487 . _:b523489937 . . _:b523489306 . . . _:b523489782 . _:b523490208 . . . _:b523490081 . . . . . "PMC0" . . . . _:b523488904 . . _:b523488821 . _:b523489445 . . . . _:b523488861 . _:b523490029 . . _:b523490003 . _:b523489540 . _:b523489259 . _:b523489383 . . _:b523489208 . _:b523490223 . _:b523489346 . _:b523489443 . _:b523490084 . _:b523489482 . _:b523489475 . _:b523489390 . _:b523489434 . _:b523489957 . . . . . _:b523489273 . . _:b523490214 . _:b523488885 . . . _:b523489493 . . _:b523489696 . . _:b523489184 . _:b523489923 . _:b523489004 . . . _:b523489379 . . . _:b523489607 . . . _:b523489330 . . . . _:b523489250 . _:b523489114 . . . _:b523489991 . _:b523489441 . . _:b523488848 . . . . _:b523489144 . _:b523489322 . _:b523488881 . . _:b523490147 . . _:b523489553 . _:b523489648 . . _:b523489927 . . _:b523489048 . _:b523489307 . . _:b523489706 . _:b22745141 "Participants underwent PiB PET imaging as described previously>>33<<, 34. Briefly, data were acquired using a Siemens/CTI ECAT HR scanner (3D mode; 63 image planes; 15.2 cm axial field of view; 5.6 mm transaxial resolution and 2.4 mm slice interval; 39 frames:" . . . _:b523489907 . _:b523489531 . _:b523489811 . _:b523489951 . _:b523489026 . . _:b523489392 . _:b523489874 . _:b523489151 . . . _:b523489370 . _:b523489686 . _:b523489597 . _:b523489713 . _:b523489819 . _:b523489955 . _:b523488957 . _:b523489194 . _:b523489756 . . . . _:b523489498 . _:b523489154 . . _:b523489861 . . . _:b523488809 . _:b523489505 . _:b523489155 . . . . . . _:b523489242 . . . _:b523489690 . _:b523489102 . _:b523489183 . _:b523489168 . . . . _:b523489309 . _:b523489787 . . . . . . _:b523489845 . _:b523489059 . _:b523490153 . _:b22745143 "This approach has been applied to numerous PiB studies>>36<<\u201339 and yields data that are similar to arterial blood input methods37." . _:b523489185 . _:b523490197 . . _:b523488923 . _:b523489791 . _:b523489486 . . . . _:b523489869 . _:b523489808 . _:b523489899 . _:b523489233 . _:b523489865 . _:b523488873 . . _:b523489668 . . . . . _:b523489014 . . _:b523489867 . _:b523489086 . . _:b523490108 . . . _:b523489789 . . . _:b523488968 . _:b523490168 . _:b523490163 . _:b523489646 . _:b523489603 . . . . _:b523489191 . _:b523489605 . _:b523490018 . _:b523488853 . _:b523489158 . . . . . . _:b523489047 . _:b523490044 . _:b523490167 . _:b523489105 . . _:b523488759 . . . _:b523489853 . _:b523489724 . . . _:b523490038 . _:b523490007 . _:b523489218 . _:b523489625 . _:b523489237 . . . . . . _:b523490228 . . . _:b523490104 . . _:b523489971 . . . . _:b523488978 . _:b523488755 . . . . _:b523488808 . _:b523489760 . . . . _:b523489513 . _:b523489197 . _:b523489532 . . . _:b523488894 . _:b523489721 . . _:b523490079 . _:b523489433 . _:b523489549 . . . _:b523488984 . . . _:b523489223 . _:b523489050 . _:b523489448 . _:b523489403 . . . . . _:b523490122 . . . _:b523489129 . . _:b523489065 . . _:b523490143 . _:b523488929 . . . _:b523488856 . . _:b523490053 . _:b523490052 . . _:b523490055 . _:b523490054 . _:b523490049 . _:b523489676 . _:b523490048 . _:b523490051 . . _:b523490050 . . _:b523490061 . _:b523490060 . _:b523489557 . . _:b523490218 . _:b523489795 . _:b523489023 . _:b523490063 . _:b523490092 . _:b523490062 . . . _:b523490057 . . _:b523490056 . _:b523490059 . _:b523489738 . _:b523489994 . . _:b523490102 . _:b523490058 . . _:b523490069 . . _:b523490068 . . _:b523490071 . _:b523490070 . . . _:b523488824 . _:b523490065 . _:b523490064 . . _:b523489198 . _:b523490067 . . _:b523489275 . _:b523488805 . . _:b523490066 . _:b523489112 . _:b523490077 . _:b523490076 . _:b523490082 . _:b523490079 . . _:b523490078 . _:b523490073 . _:b523490072 . . _:b523489359 . _:b523490075 . _:b523490074 . _:b523490085 . . _:b523489577 . _:b523490084 . _:b523490087 . _:b523488829 . . . _:b523490086 . . _:b523489601 . . . _:b523490081 . _:b523490080 . _:b523490083 . . _:b523490082 . . . _:b523490093 . _:b523490092 . _:b523488945 . _:b523490065 . . . _:b523490095 . . _:b523490094 . _:b523490089 . _:b523489240 . _:b523490088 . _:b523489115 . _:b523490091 . . _:b523490090 . _:b523489132 . _:b523490101 . . _:b523489708 . _:b523490100 . _:b523488896 . _:b523490103 . _:b523490102 . _:b523490097 . . _:b523490165 . . _:b523490096 . . _:b523490099 . _:b523489838 . _:b523489005 . _:b523490098 . _:b523490109 . _:b523490150 . . . _:b523490108 . . _:b523490048 . _:b523490111 . . _:b523490110 . _:b523489633 . _:b523490105 . . _:b523490104 . . . . _:b523490107 . _:b523490106 . _:b523489021 . _:b523490117 . . . _:b523490116 . _:b523490119 . _:b523490118 . _:b523488827 . _:b523490113 . . _:b523490112 . _:b523489500 . _:b523490115 . _:b523490114 . . _:b523488988 . _:b523488813 . _:b523490125 . . _:b523489015 . _:b523490124 . . . . _:b523488893 . _:b523490127 . . _:b523490126 . . . _:b523490193 . _:b523490207 . _:b523490121 . _:b523489082 . _:b523489034 . _:b523490120 . _:b523490123 . _:b523489290 . _:b523490122 . . _:b523488912 . _:b523489378 . _:b523490133 . _:b523490132 . _:b523490135 . _:b523489024 . _:b523490134 . . _:b523489584 . _:b523489501 . _:b523490129 . . _:b523490128 . _:b523490136 . _:b523490225 . _:b523489804 . _:b523490131 . _:b523489308 . _:b523489832 . _:b523490130 . _:b523489103 . _:b523490141 . _:b523490140 . . _:b523490143 . . _:b523490142 . _:b523490137 . . _:b523490136 . . _:b523490139 . _:b523489265 . _:b523490138 . _:b523490149 . _:b523490148 . . . _:b523488999 . _:b523490151 . _:b523490150 . _:b523490145 . _:b523490144 . _:b523490160 . _:b523490147 . _:b523489332 . _:b523490146 . _:b523490157 . _:b523490156 . _:b523490159 . _:b523490158 . . _:b523490153 . _:b22745138 "five regions (midfrontal cortex, middle temporal cortex, inferior parietal cortex, entorhinal cortex, and hippocampus CA1/subiculum) and then converted to standardized scores using the mean of the entire deceased cohort for that region>>29<<." . . _:b523490152 . . . _:b523490155 . . _:b523489336 . _:b523490154 . _:b523490165 . _:b523489440 . _:b523488833 . _:b523490164 . _:b523490167 . _:b523490166 . . _:b523489483 . . _:b523490161 . . _:b523490160 . . _:b523488863 . _:b523490163 . _:b523490162 . _:b523489582 . _:b523489781 . _:b523490173 . . _:b523489618 . _:b523490172 . _:b523489779 . _:b523489464 . _:b523490175 . _:b523490174 . . _:b523489684 . _:b523490169 . _:b523490168 . . _:b523488973 . _:b523490171 . . _:b523490170 . _:b523489777 . . _:b523490181 . . _:b523489344 . . _:b523490180 . _:b523489842 . _:b523489064 . _:b523490183 . _:b523489550 . _:b523490182 . . . _:b523490177 . _:b523490176 . _:b523490014 . _:b523490179 . _:b523488807 . _:b523490178 . _:b523490189 . _:b523489029 . _:b523490144 . _:b523488996 . _:b523490188 . _:b523489915 . _:b523489028 . _:b523490184 . _:b523490191 . _:b523489031 . . _:b523490190 . _:b523489030 . _:b523490185 . _:b523489025 . _:b523490184 . _:b523489024 . _:b523490187 . _:b523489046 . _:b523489027 . _:b523489871 . _:b523489754 . . _:b523490186 . _:b523489611 . _:b523489026 . _:b523490197 . _:b523489037 . _:b523490196 . _:b523489036 . _:b523490199 . _:b523489090 . _:b523489039 . _:b523490198 . _:b523489038 . _:b523490193 . _:b523489472 . _:b523489033 . _:b523490192 . _:b523489032 . _:b523489404 . _:b523490195 . _:b523489035 . _:b523490194 . _:b523489034 . _:b523490205 . _:b523489045 . . _:b523490204 . _:b523489044 . _:b523490207 . _:b523489047 . _:b523490206 . _:b523489087 . _:b523489046 . _:b523490201 . _:b523490229 . _:b523489041 . _:b523490200 . . . _:b523489040 . _:b523490203 . _:b523489043 . . _:b523490202 . _:b523489042 . _:b523490213 . _:b523489053 . _:b523490212 . _:b523489052 . _:b523490215 . _:b523489055 . _:b523490214 . _:b523489054 . _:b523490209 . . _:b523489049 . _:b523490208 . . _:b523489048 . _:b523490211 . _:b523489051 . _:b523490210 . _:b523489050 . . _:b523490221 . _:b523489061 . _:b523490220 . _:b523489387 . _:b523489060 . _:b523490223 . _:b523489063 . . _:b523490222 . _:b523489062 . _:b523489892 . _:b523490217 . _:b523489057 . _:b523490216 . _:b523489056 . _:b523489986 . _:b523490219 . _:b523489415 . _:b523489059 . _:b523490218 . _:b523489693 . _:b523489058 . . _:b523490229 . _:b523489069 . _:b523490228 . _:b523489068 . _:b523490231 . _:b523489071 . _:b523490230 . _:b523489070 . . _:b523490225 . _:b523490123 . _:b523489065 . _:b523490224 . _:b523489339 . _:b523489064 . _:b523490227 . _:b523489067 . . _:b523490226 . . _:b523489066 . _:b523488977 . _:b523489410 . _:b523489077 . . . . . _:b523489076 . . _:b523489079 . _:b523489078 . _:b523489085 . _:b523490233 . . _:b523489073 . _:b523490232 . . _:b523489072 . _:b523489075 . _:b523489904 . _:b523489074 . _:b22745132 . _:b523489085 . _:b523489963 . _:b523489084 . _:b523489570 . . _:b523489087 . _:b523489086 . _:b523489081 . _:b523488777 . _:b523490004 . _:b523488844 . _:b523489836 . _:b523489080 . _:b523489671 . _:b523489083 . _:b523489082 . _:b523490023 . _:b523489093 . _:b523489562 . _:b523489092 . _:b523489095 . _:b523489094 . _:b523489089 . _:b523489674 . _:b523489088 . _:b523488850 . _:b523489091 . . _:b523489090 . . _:b523489101 . _:b523489600 . _:b523489283 . _:b523489100 . . _:b523489103 . _:b523489970 . _:b523489102 . . _:b523489097 . . _:b523489096 . _:b523489099 . . . _:b523489492 . _:b523489098 . _:b523489109 . _:b523489108 . . _:b523489587 . _:b523489062 . _:b523489111 . _:b523489221 . _:b523489110 . _:b523489105 . _:b523489104 . _:b523489107 . . . . _:b523489106 . _:b523489825 . . . _:b523489753 . _:b523488992 . _:b523489130 . _:b523488975 . _:b523489117 . _:b523489905 . . . _:b523489116 . _:b22745143 . _:b523489119 . _:b523489895 . . _:b22745140 "Amyloid burden was measured with N-methyl-[11C]-2-(4-methylaminophenyl)-6-hydroxybenzothiazole (Pittsburgh Compound B; PiB), which binds to fibrillar amyloid, and was prepared at Massachusetts General Hospital as described previously31, >>32<<. Participants underwent PiB PET imaging as described previously33, 34." . _:b523489118 . . _:b523489113 . . _:b523489112 . _:b523489115 . . _:b523489114 . _:b523489602 . _:b523489125 . _:b523489897 . _:b523489124 . _:b523489127 . . _:b523489126 . . . _:b523489121 . . _:b22745146 . _:b523489120 . . _:b523488901 . _:b523489935 . _:b523489123 . . _:b523489122 . . _:b523489133 . _:b523489132 . _:b523489541 . . _:b523489622 . _:b523489135 . _:b523489134 . _:b523489129 . . _:b523489510 . _:b523489128 . . _:b523488787 . . _:b523489131 . _:b523489130 . _:b523489778 . _:b523489141 . _:b523489140 . . _:b523489143 . _:b523489938 . _:b523489093 . _:b523489142 . _:b523489478 . _:b523489137 . _:b523489868 . _:b523489136 . _:b523489638 . _:b523488858 . _:b523489139 . . _:b523490125 . . _:b523489138 . _:b523488767 . . _:b523489797 . _:b523489149 . _:b523489341 . _:b523489796 . _:b523489148 . _:b523489799 . _:b523489151 . _:b523489032 . _:b523488967 . . _:b523489798 . _:b523489150 . _:b523489793 . _:b523489898 . _:b523489145 . . _:b523489792 . _:b22745139 "Amyloid burden was measured with N-methyl-[11C]-2-(4-methylaminophenyl)-6-hydroxybenzothiazole (Pittsburgh Compound B; PiB), which binds to fibrillar amyloid, and was prepared at Massachusetts General Hospital as described previously>>31<<, 32. Participants underwent PiB PET imaging as described previously33, 34." . _:b523489144 . _:b523489636 . _:b523489795 . _:b523489147 . . _:b523489043 . _:b523489794 . _:b523489146 . _:b523489135 . _:b523489805 . _:b523489157 . _:b523489496 . _:b523489804 . . _:b523489156 . . _:b523489807 . _:b523489247 . _:b523489159 . _:b523489806 . _:b523489158 . _:b523489161 . _:b523489801 . _:b523489153 . _:b523489775 . _:b523489800 . _:b523489152 . _:b523490034 . _:b523489803 . _:b523489155 . _:b523489010 . _:b523489802 . _:b523489154 . . . . _:b523489813 . _:b523489165 . . _:b523489812 . _:b523489164 . _:b523490233 . . _:b523489815 . _:b523489167 . _:b523489067 . _:b523489814 . _:b523489166 . _:b523489809 . _:b523489533 . _:b523489161 . _:b523489808 . _:b523489552 . _:b523489160 . _:b523489811 . _:b523489163 . _:b523489810 . _:b523489162 . _:b523489821 . _:b523489173 . _:b523489442 . . _:b523489820 . _:b523489882 . _:b523489172 . _:b523490062 . _:b523489823 . . _:b523489175 . _:b523490057 . _:b523489822 . . _:b523489174 . . _:b523489817 . _:b523488966 . _:b523488886 . _:b523489169 . . _:b523489816 . _:b523489168 . _:b523489819 . _:b523489171 . _:b523488756 . _:b523489564 . _:b523489818 . _:b523489170 . _:b523489829 . _:b523489181 . _:b523489828 . _:b523489180 . _:b523489831 . _:b523489183 . . _:b523489830 . _:b523489182 . _:b523489825 . _:b523489177 . _:b523489824 . _:b523489176 . _:b523488982 . . _:b523489827 . _:b523489266 . _:b523489179 . _:b523489826 . _:b523489178 . _:b523489837 . _:b523489189 . _:b523489836 . _:b523489188 . _:b523489071 . _:b523489839 . _:b523489431 . _:b523489191 . _:b523490119 . . _:b523489181 . _:b523489838 . _:b523489190 . _:b523489833 . _:b523489244 . _:b523489798 . _:b523489185 . _:b523489412 . . _:b523489832 . _:b523489184 . . _:b523489835 . . _:b523489187 . _:b523489834 . _:b523489186 . . _:b523489845 . _:b523489197 . . _:b523489844 . _:b523489196 . . _:b523489407 . . _:b523489847 . _:b523489199 . . _:b523489846 . _:b523489198 . _:b523489841 . _:b523489193 . _:b523489840 . _:b523489192 . . _:b523489843 . _:b523489195 . _:b523489842 . _:b523489028 . _:b523489194 . _:b523489029 . _:b523489030 . _:b523489031 . _:b523489853 . _:b523489024 . _:b523489205 . _:b523489025 . _:b523489026 . _:b523489027 . _:b523489852 . _:b523489036 . _:b523489204 . . _:b523489037 . _:b523489038 . _:b523489235 . _:b523489039 . _:b523489855 . _:b523488998 . _:b523489032 . _:b523489207 . _:b523489033 . _:b523489034 . _:b523489035 . _:b523489854 . . _:b523489044 . _:b523489206 . _:b523489045 . _:b523489046 . . _:b523489047 . _:b523489849 . _:b523489040 . _:b523489201 . _:b523489881 . _:b523489041 . _:b523489042 . _:b523489043 . _:b523489848 . _:b523489052 . _:b523489200 . _:b523489053 . _:b523489054 . _:b523489055 . _:b523489851 . _:b523489048 . _:b523489203 . _:b523489049 . _:b523489050 . _:b523489051 . _:b523489850 . _:b523489060 . _:b523489202 . . _:b523489061 . _:b523489062 . _:b523489912 . _:b523489063 . _:b523489861 . _:b523489056 . _:b523489213 . _:b523489057 . . _:b523489058 . _:b523489059 . _:b523489860 . . _:b523489068 . _:b523489212 . _:b523489069 . _:b523489070 . . _:b523489863 . _:b523489071 . _:b523489064 . _:b523489215 . _:b523489065 . _:b523489066 . _:b523489067 . _:b523489862 . . _:b523489076 . . _:b523489214 . _:b523489077 . . _:b523489078 . _:b523489079 . _:b523489857 . _:b523489072 . _:b523489890 . _:b523489209 . _:b523489073 . _:b523489074 . _:b523489075 . _:b523489856 . _:b523489084 . _:b523489208 . _:b523489085 . _:b523489086 . _:b523489087 . _:b523489859 . . _:b523489080 . _:b523489593 . _:b523489134 . _:b523489211 . _:b523489081 . _:b523489252 . _:b523489082 . _:b523489083 . _:b523489858 . _:b523489092 . _:b523489210 . _:b523489093 . _:b523489094 . _:b523490185 . _:b523489095 . _:b523489869 . _:b523489068 . _:b523489088 . _:b523489221 . _:b523489089 . _:b523489090 . _:b523489091 . _:b523489868 . _:b523489100 . _:b523489220 . _:b523489101 . _:b523489102 . _:b523489103 . _:b523489871 . _:b523489096 . _:b523489223 . _:b523489097 . _:b523489098 . _:b523489099 . _:b523489870 . . _:b523489108 . _:b523489222 . _:b523489109 . _:b523489110 . _:b523489111 . _:b523489865 . . _:b523489104 . _:b523489217 . . _:b523489105 . _:b523489106 . _:b523489107 . _:b523489864 . _:b523489116 . _:b523489216 . _:b523489117 . . _:b523489850 . _:b523489118 . _:b523489119 . _:b523489867 . . _:b523489112 . _:b523489219 . _:b523489113 . _:b523489114 . _:b523489115 . _:b523489866 . _:b523489124 . _:b523489218 . _:b523489125 . _:b523489126 . _:b523489127 . _:b523489877 . . _:b523489120 . _:b523489229 . _:b523489017 . _:b523489121 . _:b523489122 . . . _:b523489876 . _:b523489123 . _:b523489132 . _:b523489228 . _:b523489133 . _:b523489134 . _:b523489135 . _:b523489879 . _:b523489128 . _:b523489231 . _:b523489129 . _:b523489130 . _:b523489131 . _:b523489878 . . _:b523489140 . _:b523489230 . _:b523489141 . _:b523489142 . _:b523489143 . _:b523489873 . _:b523489136 . _:b523489225 . _:b523489137 . _:b523489138 . 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