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PMC0
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10.1038%2Fnature12972
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supplementary material
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The bars reproduce the findings of a fixed clonal assay using the same Lgr5-Confetti mouse construct used in the present study and first presented in Ref. [>>7<<]. Error bars denote SEM.
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assay (see Fig. 3 and supplementary notes) following the representative marking of stem cells at the crypt base, and the line shows the predictions of the strictly one-dimensional neutral drift dynamics model introduced in Ref. [>>8<<] with a stem cell loss replacement rate of 0.24 per day and a total of 8 stem cells.
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these parameters translate to the ratio ╬╗pcc/Nstem2 =0.026 per week, very close to the figure of 0.025 per week obtained from a fit of the measured monoclonal crypt fraction to the one-dimensional neutral drift dynamics model in Ref. [>>8<<]. (For the labeling protocol and the experimental data points, we refer to the original reference).
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online-only methods
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To obtain R26R-Confetti; Lgr5-EGFP-Ires-CreERT2 mice, R26R-Confetti>>7<< mice were crossed with Lgr5-EGFP-Ires-CreERT21.
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To obtain R26R-Confetti; Lgr5-EGFP-Ires-CreERT2 mice, R26R-Confetti7 mice were crossed with Lgr5-EGFP-Ires-CreERT>>21<<. Random double heterozygous male mice between 10-22 weeks old were used for experiments. Three days before imaging, mice were injected with 2.5-5 mg Tamoxifen (single injection; Sigma Aldrich) to induce activation of Cre recombinase to
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