_:b32492095 "This phenomenon is known as \u2018enhanced permeation and retention\u2019 (EPR) [58,>>60<<]. The drug-dendrimer conjugates show high solubility, reduced systemic toxicity, and selective accumulation in solid tumors." . . _:b556070324 . _:b556070547 . _:b556070419 . _:b556070317 . _:b556070706 . _:b556070446 . . _:b556070570 . . _:b556070691 . _:b556070313 . _:b556070709 . . . . . _:b556070445 . . _:b556070339 . . _:b556070489 . _:b556070438 . . _:b556070253 . . . _:b556070601 . _:b556070444 . _:b556070257 . . . . . . . _:b556070519 . _:b32492102 "Furthermore, highly sensitive analytical devices [77,78], MRI contrast agents [79], prion research [80], burn treatment [>>81<<], and EPR imaging with spin-labeled dendrimers [82-106] are some of the diverse areas of fascinating ongoing dendrimer research that are beyond the scope of this article." . _:b32492091 "They relate to the molecular chemistry world by virtue of their step-by-step controlled synthesis, and they relate to the polymer world because of their repetitive structure made of monomers [>>32<<-35]. The three traditional macromolecular architectural classes (i.e., linear, cross-linked, and branched) are broadly recognized to generate rather polydisperse products of different molecular weights. In contrast, the synthesis of" . _:b556070662 . . . . _:b556070233 . . _:b556070216 . . _:b556070357 . . _:b556070306 . _:b556070563 . _:b32492100 . _:b556070695 . . . _:b556070401 . . . _:b556070186 . _:b556070587 . . _:b556070214 . _:b556070595 . . . . _:b556070638 . _:b556070694 . _:b556070374 . . . _:b556070263 . . _:b556070213 . . . . _:b556070492 . _:b556070405 "2"^^ . _:b556070404 "2"^^ . _:b556070407 "2"^^ . _:b556070400 . _:b556070411 . _:b556070406 "2"^^ . _:b556070401 "2"^^ . _:b556070400 "2"^^ . _:b556070231 . _:b556070403 "2"^^ . . _:b32492089 . _:b556070402 "2"^^ . . . . _:b32492094 . _:b556070413 "2"^^ . . _:b556070412 "2"^^ . _:b556070415 "2"^^ . _:b556070414 "2"^^ . . _:b556070409 "2"^^ . _:b556070408 "2"^^ . . _:b556070384 . _:b556070411 "2"^^ . . _:b556070410 "2"^^ . _:b556070421 "2"^^ . _:b556070180 . _:b556070420 "2"^^ . _:b556070423 "2"^^ . _:b556070353 . . _:b556070422 "2"^^ . _:b556070417 "2"^^ . . _:b556070468 . _:b556070416 "2"^^ . . _:b556070419 "2"^^ . _:b556070418 "2"^^ . _:b556070429 "2"^^ . _:b556070161 . _:b556070428 "2"^^ . _:b556070707 . _:b556070431 "2"^^ . _:b556070430 "2"^^ . _:b556070425 "2"^^ . . _:b556070424 "2"^^ . . _:b556070427 "2"^^ . _:b556070426 "2"^^ . _:b556070502 . _:b556070437 "2"^^ . _:b556070436 "2"^^ . _:b556070439 "2"^^ . _:b556070438 "2"^^ . _:b556070716 . _:b556070433 "2"^^ . _:b556070630 . _:b556070220 . . _:b556070556 . _:b556070432 "2"^^ . . . _:b556070435 "2"^^ . . _:b556070434 "2"^^ . . _:b556070445 "2"^^ . . . _:b556070435 . _:b556070444 "2"^^ . _:b556070447 "2"^^ . _:b556070446 "2"^^ . _:b556070495 . _:b556070441 "2"^^ . _:b556070184 . _:b556070185 . _:b556070432 . _:b556070186 . _:b556070187 . _:b556070440 "2"^^ . _:b556070188 . _:b556070189 . _:b556070190 . . _:b556070387 . _:b556070191 . _:b556070443 "2"^^ . _:b556070499 . _:b556070176 . _:b556070177 . _:b556070178 . _:b556070179 . _:b556070442 "2"^^ . _:b556070180 . _:b556070181 . _:b556070182 . _:b556070183 . _:b556070453 "2"^^ . _:b556070200 . _:b556070201 . _:b556070202 . _:b556070203 . _:b556070452 "2"^^ . _:b556070204 . _:b556070205 . _:b556070206 . _:b556070207 . _:b556070455 "2"^^ . _:b556070192 . _:b556070193 . _:b556070194 . . _:b556070454 "2"^^ . _:b556070195 . _:b556070196 . _:b556070197 . _:b556070198 . _:b556070199 . _:b556070449 "2"^^ . . _:b556070458 . _:b556070448 "2"^^ . _:b556070451 "2"^^ . . . _:b556070592 . . _:b556070450 "2"^^ . . _:b556070461 "2"^^ . _:b556070168 . _:b556070169 . _:b556070170 . _:b556070171 . _:b556070460 "2"^^ . _:b556070172 . _:b556070173 . _:b556070174 . _:b556070175 . _:b556070463 "2"^^ . _:b556070161 . _:b556070162 . _:b556070163 . _:b556070462 "2"^^ . _:b556070164 . _:b556070165 . _:b556070473 . _:b556070166 . . _:b556070457 "2"^^ . _:b556070167 . _:b556070248 . _:b556070249 . _:b556070250 . _:b556070251 . _:b556070456 "2"^^ . _:b556070252 . _:b556070253 . _:b556070609 . _:b556070312 . _:b556070254 . _:b556070255 . _:b556070459 "2"^^ . _:b556070240 . _:b556070241 . _:b556070430 . _:b556070242 . _:b556070598 . _:b556070243 . _:b556070458 "2"^^ . _:b556070244 . _:b556070245 . . _:b556070246 . _:b556070334 . _:b556070469 "2"^^ . _:b556070247 . _:b556070264 . _:b556070265 . _:b556070266 . _:b556070267 . _:b556070468 "2"^^ . _:b556070268 . _:b556070410 . _:b556070269 . _:b556070270 . _:b556070717 . _:b556070271 . _:b556070471 "2"^^ . _:b556070256 . . _:b556070257 . _:b556070258 . _:b556070259 . _:b556070470 "2"^^ . _:b556070260 . _:b556070261 . _:b556070262 . _:b556070263 . _:b556070465 "2"^^ . _:b556070216 . _:b556070217 . _:b556070218 . _:b556070219 . _:b556070464 "2"^^ . _:b556070220 . _:b556070221 . _:b556070222 . _:b556070223 . _:b556070467 "2"^^ . _:b556070208 . _:b556070209 . _:b556070210 . _:b556070211 . _:b556070323 . _:b556070466 "2"^^ . _:b556070212 . _:b556070213 . _:b556070214 . _:b556070215 . _:b556070477 "2"^^ . . _:b556070232 . _:b556070233 . _:b556070234 . _:b556070235 . _:b556070476 "2"^^ . _:b556070236 . _:b556070237 . _:b556070238 . _:b556070239 . _:b556070479 "2"^^ . _:b556070224 . _:b556070225 . _:b556070226 . _:b556070227 . _:b556070478 "2"^^ . _:b556070228 . _:b556070284 . _:b556070229 . _:b556070230 . _:b556070231 . _:b556070473 "2"^^ . _:b556070312 . _:b556070313 . _:b556070314 . _:b556070315 . _:b556070391 . _:b556070472 "2"^^ . _:b556070316 . _:b556070317 . . _:b556070318 . _:b556070319 . _:b556070475 "2"^^ . _:b556070304 . _:b556070305 . . _:b556070644 . _:b556070306 . _:b32492087 "The advantages of these well-defined materials make them the newest class of macromolecular nano-scale delivery devices [>>18<<]. Dendritic macromolecules tend to linearly increase in diameter and adopt a more globular shape with increasing dendrimer generation. Therefore, dendrimers have become an ideal delivery vehicle candidate for explicit study of the effects" . _:b556070307 . _:b556070474 "2"^^ . _:b556070308 . _:b556070309 . _:b556070310 . _:b556070311 . _:b556070485 "2"^^ . _:b556070328 . _:b556070329 . _:b556070330 . _:b556070331 . _:b556070484 "2"^^ . _:b556070332 . _:b556070333 . . _:b556070334 . _:b556070335 . _:b556070487 "2"^^ . _:b556070320 . _:b556070321 . _:b556070322 . _:b556070323 . _:b556070486 "2"^^ . _:b556070324 . _:b556070325 . _:b556070326 . _:b556070327 . _:b556070481 "2"^^ . _:b556070280 . . _:b556070281 . _:b556070569 . _:b556070282 . _:b556070283 . _:b556070480 "2"^^ . _:b556070284 . _:b556070285 . _:b556070286 . _:b556070287 . _:b556070483 "2"^^ . _:b556070272 . _:b556070273 . _:b556070274 . . _:b556070275 . _:b556070482 "2"^^ . _:b556070276 . _:b556070277 . . _:b556070278 . _:b556070279 . _:b556070187 . _:b556070493 "2"^^ . _:b556070296 . _:b556070297 . _:b556070298 . _:b556070453 . _:b556070492 "2"^^ . _:b556070299 . _:b556070300 . _:b556070301 . _:b556070302 . _:b556070303 . _:b556070495 "2"^^ . _:b556070288 . . _:b556070289 . . _:b556070290 . _:b556070291 . _:b556070531 . _:b556070494 "2"^^ . _:b556070292 . _:b556070206 . _:b556070293 . _:b556070294 . _:b556070295 . _:b556070489 "2"^^ . _:b556070376 . _:b556070377 . _:b556070378 . _:b556070379 . _:b556070488 "2"^^ . _:b556070380 . _:b556070404 . _:b556070381 . _:b556070382 . _:b556070383 . . _:b556070491 "2"^^ . _:b556070368 . _:b556070369 . _:b556070370 . _:b556070371 . _:b556070490 "2"^^ . _:b556070372 . . _:b556070726 . _:b556070373 . _:b556070374 . _:b556070375 . _:b556070501 "2"^^ . _:b556070392 . _:b556070393 . _:b556070337 . _:b556070349 . _:b556070394 . _:b556070395 . _:b556070500 "2"^^ . _:b556070396 . _:b556070397 . _:b556070526 . _:b556070398 . _:b556070399 . _:b556070503 "2"^^ . _:b556070384 . _:b556070243 . . _:b556070385 . _:b556070386 . _:b32492092 "In this strategy, the final generation number is pre-determined, necessitating the synthesis of branches of a variety of requisite sizes beforehand for each generation [>>41<<] (Figure\u00A05)." . _:b556070249 . _:b556070387 . _:b556070488 . _:b556070502 "2"^^ . _:b556070388 . _:b556070389 . _:b556070390 . _:b556070391 . _:b556070497 "2"^^ . _:b556070344 . _:b556070345 . _:b556070346 . _:b556070347 . _:b556070496 "2"^^ . _:b556070348 . _:b556070349 . _:b556070350 . _:b556070351 . _:b556070499 "2"^^ . _:b556070336 . _:b556070337 . . _:b556070338 . _:b556070339 . _:b556070498 "2"^^ . _:b556070340 . _:b556070341 . _:b556070342 . _:b556070718 . _:b556070343 . . _:b556070509 "2"^^ . _:b556070620 . _:b556070360 . _:b556070361 . _:b556070362 . _:b556070363 . _:b556070508 "2"^^ . _:b556070364 . _:b556070365 . _:b556070366 . _:b556070367 . _:b556070511 "2"^^ . _:b556070352 . _:b556070353 . _:b556070354 . _:b556070278 . _:b556070510 "2"^^ . _:b556070355 . _:b556070649 . _:b556070356 . _:b556070357 . _:b556070326 . _:b556070358 . _:b556070641 . _:b556070359 . . _:b556070505 "2"^^ . _:b556070193 . _:b556070504 "2"^^ . . _:b556070507 "2"^^ . _:b556070582 . _:b556070506 "2"^^ . _:b556070600 . _:b556070517 "2"^^ . _:b556070516 "2"^^ . _:b556070519 "2"^^ . . _:b556070518 "2"^^ . . _:b556070513 "2"^^ . _:b556070512 "2"^^ . _:b556070515 "2"^^ . _:b556070451 . . _:b556070604 . _:b556070514 "2"^^ . . _:b556070525 "2"^^ . _:b556070524 "2"^^ . _:b32492098 . _:b556070669 . _:b556070527 "2"^^ . _:b556070526 "2"^^ . _:b556070275 . _:b556070521 "2"^^ . . _:b556070520 "2"^^ . _:b556070664 . _:b556070723 . _:b556070523 "2"^^ . _:b556070572 . _:b556070522 "2"^^ . _:b556070533 "2"^^ . . _:b556070532 "2"^^ . _:b556070535 "2"^^ . _:b556070534 "2"^^ . _:b556070529 "2"^^ . _:b556070304 . _:b556070239 . _:b556070528 "2"^^ . _:b556070551 . _:b556070288 . _:b556070531 "2"^^ . . . _:b556070530 "2"^^ . _:b556070541 "2"^^ . _:b556070540 "2"^^ . _:b556070496 . . . _:b556070209 . _:b556070543 "2"^^ . _:b556070542 "2"^^ . _:b556070298 . _:b556070537 "2"^^ . _:b556070536 "2"^^ . _:b556070246 . _:b556070539 "2"^^ . . . . _:b556070689 . _:b556070538 "2"^^ . . _:b556070549 "2"^^ . _:b556070612 . _:b556070548 "2"^^ . . . _:b556070551 "2"^^ . . _:b556070550 "2"^^ . _:b556070585 . _:b556070260 . _:b556070545 "2"^^ . . . _:b556070544 "2"^^ . . . _:b32492095 . _:b556070594 . _:b556070347 . _:b556070547 "2"^^ . . . _:b556070546 "2"^^ . _:b556070557 "2"^^ . _:b556070398 . _:b556070556 "2"^^ . _:b556070484 . _:b32492086 "are hyperbranched macromolecules with a carefully tailored architecture, the end-groups (i.e., the groups reaching the outer periphery), which can be functionalized, thus modifying their physicochemical or biological properties [>>11<<-16]. Dendrimers have gained a broad range of applications in supramolecular chemistry, particularly in host-guest reactions and self-assembly processes." . . _:b556070559 "2"^^ . . _:b556070558 "2"^^ . . _:b556070553 "2"^^ . _:b556070452 . _:b556070205 . _:b556070552 "2"^^ . _:b556070555 "2"^^ . . . . _:b556070554 "2"^^ . _:b556070565 "2"^^ . . _:b556070564 "2"^^ . _:b556070567 "2"^^ . _:b556070566 "2"^^ . . . _:b556070561 "2"^^ . _:b556070375 . _:b556070316 . _:b556070558 . _:b556070729 . _:b556070560 "2"^^ . . . . _:b556070563 "2"^^ . _:b556070548 . _:b556070309 . _:b556070562 "2"^^ . _:b556070573 "2"^^ . _:b556070325 . _:b556070572 "2"^^ . _:b556070575 "2"^^ . . _:b556070574 "2"^^ . _:b556070569 "2"^^ . _:b556070696 . _:b556070697 . _:b556070698 . . _:b556070568 "2"^^ . _:b556070699 . _:b556070700 . _:b556070701 . _:b556070702 . _:b556070703 . _:b556070571 "2"^^ . _:b556070688 . _:b556070689 . _:b556070690 . _:b556070691 . _:b556070570 "2"^^ . _:b556070692 . _:b556070693 . _:b556070694 . . _:b556070581 "2"^^ . _:b556070695 . _:b556070712 . _:b556070713 . _:b556070714 . _:b556070715 . _:b556070580 "2"^^ . _:b556070716 . _:b556070596 . _:b556070717 . _:b556070192 . . _:b556070718 . . . _:b556070583 "2"^^ . _:b556070719 . _:b556070704 . _:b556070705 . _:b556070706 . _:b556070707 . _:b556070582 "2"^^ . . _:b556070708 . _:b556070709 . _:b556070656 . . _:b556070710 . _:b556070711 . . _:b556070577 "2"^^ . _:b556070664 . . _:b556070665 . _:b556070666 . _:b556070667 . _:b556070576 "2"^^ . _:b556070668 . _:b556070504 . _:b556070669 . _:b556070238 . _:b556070670 . _:b556070671 . _:b556070579 "2"^^ . . _:b556070656 . _:b556070657 . _:b556070658 . _:b556070659 . _:b556070578 "2"^^ . _:b556070660 . _:b556070661 . _:b556070662 . _:b556070293 . . _:b556070589 "2"^^ . _:b556070663 . _:b556070680 . _:b556070681 . _:b556070682 . _:b556070683 . _:b556070588 "2"^^ . _:b556070684 . _:b556070685 . _:b556070686 . _:b556070687 . _:b556070591 "2"^^ . _:b556070672 . _:b32492092 . _:b556070673 . _:b556070674 . _:b556070340 . _:b556070590 "2"^^ . _:b556070675 . _:b556070676 . _:b556070677 . _:b556070543 . _:b556070678 . _:b556070679 . _:b556070585 "2"^^ . _:b556070486 . _:b556070584 "2"^^ . _:b556070587 "2"^^ . _:b556070586 "2"^^ . _:b556070597 "2"^^ . . _:b556070596 "2"^^ . _:b556070395 . . _:b556070599 "2"^^ . _:b556070598 "2"^^ . _:b556070593 "2"^^ . _:b556070728 . _:b556070729 . _:b556070730 . _:b556070731 . _:b556070592 "2"^^ . _:b556070732 . _:b556070361 . _:b556070595 "2"^^ . _:b556070720 . _:b556070721 . _:b556070722 . _:b556070723 . _:b556070594 "2"^^ . . _:b556070724 . _:b556070725 . _:b556070726 . _:b556070727 . _:b556070605 "2"^^ . . . _:b556070604 "2"^^ . _:b556070396 . _:b556070607 "2"^^ . _:b556070606 "2"^^ . _:b556070601 "2"^^ . _:b556070600 "2"^^ . _:b556070188 . _:b556070603 "2"^^ . _:b32492103 . _:b556070602 "2"^^ . . _:b556070613 "2"^^ . _:b556070612 "2"^^ . _:b32492103 . "PMC0" . _:b556070639 . _:b556070615 "2"^^ . _:b556070370 . _:b32492091 . _:b556070614 "2"^^ . . _:b556070609 "2"^^ . _:b556070608 "2"^^ . _:b556070611 "2"^^ . _:b32492102 . _:b556070610 "2"^^ . . . _:b32492096 . _:b556070621 "2"^^ . _:b556070620 "2"^^ . . _:b556070623 "2"^^ . _:b556070622 "2"^^ . . _:b556070617 "2"^^ . . _:b556070616 "2"^^ . . _:b556070619 "2"^^ . _:b556070618 "2"^^ . _:b556070201 . . _:b556070629 "2"^^ . _:b556070628 "2"^^ . . . _:b556070416 . _:b556070631 "2"^^ . _:b556070630 "2"^^ . _:b556070625 "2"^^ . _:b556070624 "2"^^ . _:b556070211 . _:b556070627 "2"^^ . . _:b556070626 "2"^^ . . . _:b556070637 "2"^^ . _:b556070330 . . _:b556070636 "2"^^ . _:b556070643 . _:b556070639 "2"^^ . . _:b556070638 "2"^^ . . _:b556070633 "2"^^ . _:b32492103 . _:b556070440 . _:b556070441 . _:b556070442 . _:b556070443 . _:b556070632 "2"^^ . _:b556070544 . _:b556070444 . _:b556070445 . . _:b556070446 . _:b556070276 . _:b556070635 "2"^^ . _:b556070447 . _:b556070432 . _:b556070433 . _:b556070434 . _:b556070435 . _:b556070634 "2"^^ . _:b556070436 . _:b556070437 . _:b556070438 . _:b556070658 . _:b556070645 "2"^^ . _:b556070439 . _:b556070456 . _:b556070457 . . _:b556070169 . _:b556070458 . . _:b556070644 "2"^^ . _:b556070459 . _:b556070460 . . _:b556070461 . _:b556070462 . _:b556070463 . _:b556070647 "2"^^ . _:b556070448 . _:b556070230 . _:b556070449 . _:b556070450 . _:b556070388 . _:b556070451 . _:b556070646 "2"^^ . _:b556070452 . _:b556070453 . _:b556070627 . _:b556070454 . _:b556070386 . _:b556070455 . _:b556070641 "2"^^ . _:b556070408 . _:b556070409 . _:b556070410 . _:b556070411 . _:b556070640 "2"^^ . . _:b556070412 . _:b556070413 . _:b556070414 . _:b556070415 . _:b556070643 "2"^^ . _:b556070400 . _:b556070401 . _:b556070402 . _:b556070403 . _:b556070642 "2"^^ . _:b556070404 . _:b556070405 . _:b556070406 . _:b556070407 . _:b556070653 "2"^^ . _:b556070424 . _:b556070425 . _:b556070457 . _:b556070426 . _:b556070427 . _:b556070652 "2"^^ . _:b556070428 . _:b556070254 . _:b556070429 . _:b556070430 . "10.1186%2F1556-276X-9-247" . _:b556070655 "2"^^ . _:b556070431 . _:b556070416 . _:b556070417 . _:b556070418 . _:b556070567 . _:b556070419 . _:b556070654 "2"^^ . _:b556070420 . _:b556070421 . _:b556070422 . _:b556070423 . _:b556070649 "2"^^ . _:b556070504 . _:b556070226 . _:b556070505 . _:b556070506 . _:b556070507 . _:b556070648 "2"^^ . _:b556070730 . _:b556070508 . _:b556070509 . _:b556070510 . _:b556070511 . . _:b556070651 "2"^^ . _:b556070481 . _:b556070496 . _:b556070497 . _:b556070498 . _:b556070499 . _:b556070650 "2"^^ . _:b556070500 . _:b556070501 . _:b556070502 . _:b556070700 . _:b556070661 "2"^^ . _:b556070503 . _:b556070520 . _:b556070521 . _:b556070522 . _:b556070523 . _:b556070660 "2"^^ . _:b556070524 . _:b556070525 . _:b556070526 . _:b556070527 . . _:b556070663 "2"^^ . _:b556070512 . _:b556070513 . _:b556070514 . _:b556070179 . _:b556070515 . _:b556070662 "2"^^ . _:b556070516 . _:b556070441 . _:b556070517 . _:b556070518 . _:b556070519 . _:b556070657 "2"^^ . _:b556070472 . _:b556070473 . _:b556070474 . _:b556070475 . _:b556070656 "2"^^ . _:b556070476 . _:b556070477 . _:b556070478 . _:b556070479 . _:b556070358 . _:b556070659 "2"^^ . _:b556070464 . . _:b556070465 . _:b556070466 . _:b556070467 . _:b556070658 "2"^^ . _:b556070468 . _:b556070469 . _:b556070331 . _:b556070470 . _:b556070471 . _:b556070669 "2"^^ . _:b556070488 . _:b556070489 . _:b556070490 . _:b556070491 . _:b556070668 "2"^^ . _:b556070492 . _:b556070493 . _:b556070342 . _:b556070494 . _:b556070495 . _:b556070671 "2"^^ . _:b556070480 . _:b556070377 . _:b556070481 . _:b556070482 . _:b556070483 . _:b556070670 "2"^^ . _:b556070484 . _:b556070673 . _:b556070485 . _:b556070486 . . _:b556070665 "2"^^ . _:b556070487 . _:b556070568 . _:b556070569 . _:b556070570 . _:b556070571 . _:b556070664 "2"^^ . _:b556070572 . _:b556070573 . _:b556070574 . _:b556070575 . _:b556070667 "2"^^ . _:b556070560 . _:b556070561 . _:b556070270 . _:b556070562 . _:b556070563 . _:b556070666 "2"^^ . _:b556070564 . _:b556070565 . _:b556070566 . _:b556070567 . _:b556070677 "2"^^ . _:b556070584 . _:b556070585 . _:b556070586 . _:b556070587 . _:b556070676 "2"^^ . _:b556070588 . _:b556070589 . _:b556070590 . _:b556070591 . _:b556070679 "2"^^ . _:b556070576 . _:b556070577 . . _:b556070578 . _:b556070579 . _:b556070678 "2"^^ . _:b556070580 . _:b556070581 . . _:b556070425 . _:b556070582 . . _:b556070673 "2"^^ . _:b556070583 . _:b556070536 . _:b556070537 . _:b556070538 . _:b556070539 . _:b556070672 "2"^^ . _:b556070540 . _:b556070541 . _:b556070542 . _:b556070543 . _:b556070675 "2"^^ . _:b556070528 . _:b556070529 . _:b556070530 . _:b556070531 . _:b556070674 "2"^^ . _:b556070532 . _:b556070533 . . _:b556070605 . _:b556070534 . _:b556070535 . _:b556070685 "2"^^ . _:b556070552 . _:b556070553 . . _:b556070554 . _:b556070555 . _:b556070684 "2"^^ . _:b556070556 . _:b556070557 . _:b556070558 . _:b556070508 . _:b556070687 "2"^^ . _:b556070559 . _:b556070544 . _:b556070545 . . _:b556070546 . _:b556070547 . _:b556070702 . _:b556070686 "2"^^ . _:b32492086 . _:b556070548 . _:b556070549 . _:b556070550 . _:b556070551 . _:b556070681 "2"^^ . _:b556070632 . _:b556070633 . _:b556070634 . _:b556070635 . _:b556070680 "2"^^ . _:b556070636 . _:b556070637 . _:b556070638 . _:b556070639 . _:b556070683 "2"^^ . _:b556070624 . _:b556070625 . _:b556070626 . _:b556070627 . . _:b556070682 "2"^^ . _:b556070628 . _:b556070629 . _:b556070630 . _:b556070631 . _:b556070693 "2"^^ . _:b556070648 . _:b556070649 . _:b556070650 . _:b556070651 . _:b556070692 "2"^^ . _:b556070652 . _:b556070653 . _:b556070654 . _:b556070655 . _:b556070695 "2"^^ . . _:b556070640 . _:b556070641 . . _:b556070642 . _:b556070643 . . _:b556070694 "2"^^ . _:b556070644 . _:b556070645 . _:b556070646 . _:b556070647 . _:b556070689 "2"^^ . _:b556070600 . _:b556070601 . _:b556070602 . _:b556070603 . _:b556070688 "2"^^ . _:b556070604 . _:b556070605 . _:b556070606 . _:b556070607 . _:b556070691 "2"^^ . . _:b556070592 . _:b556070345 . _:b556070593 . _:b556070594 . _:b556070595 . _:b556070690 "2"^^ . _:b556070596 . _:b556070597 . _:b556070598 . _:b556070599 . _:b556070701 "2"^^ . _:b556070616 . _:b556070617 . _:b556070618 . _:b556070619 . _:b556070700 "2"^^ . _:b556070620 . _:b556070621 . _:b556070622 . _:b556070623 . _:b556070703 "2"^^ . _:b556070608 . _:b556070609 . _:b556070610 . _:b556070611 . _:b556070702 "2"^^ . _:b556070602 . _:b556070612 . _:b556070613 . _:b556070614 . . . _:b556070615 . _:b556070697 "2"^^ . _:b556070696 "2"^^ . . _:b556070699 "2"^^ . . _:b556070626 . _:b556070698 "2"^^ . _:b556070709 "2"^^ . _:b556070708 "2"^^ . _:b556070711 "2"^^ . _:b556070710 "2"^^ . _:b556070352 . _:b556070705 "2"^^ . . . _:b556070704 "2"^^ . _:b556070469 . . . _:b556070707 "2"^^ . _:b556070706 "2"^^ . . _:b556070717 "2"^^ . _:b556070716 "2"^^ . _:b556070512 . _:b556070719 "2"^^ . . _:b556070653 . _:b556070718 "2"^^ . _:b556070713 "2"^^ . _:b556070712 "2"^^ . . _:b556070421 . _:b556070715 "2"^^ . . _:b556070714 "2"^^ . _:b556070399 . _:b556070725 "2"^^ . _:b556070459 . _:b556070203 . . _:b556070724 "2"^^ . . _:b556070727 "2"^^ . _:b556070726 "2"^^ . _:b556070721 "2"^^ . _:b556070732 . _:b556070720 "2"^^ . _:b556070723 "2"^^ . _:b556070722 "2"^^ . _:b556070732 "2"^^ . . . _:b556070729 "2"^^ . _:b556070185 . . . _:b556070728 "2"^^ . _:b556070731 "2"^^ . _:b556070730 "2"^^ . . _:b556070487 . . . _:b556070477 . _:b32492097 . . _:b556070413 . . _:b32492090 "Their chemistry is one of the most attractive and hastily growing areas of new chemistry [>>25<<-27]. Dendrimer chemistry, as other specialized research fields, has its own terms and abbreviations. Furthermore, a more brief structural nomenclature is applied to describe the different chemical events taking place at the dendrimer" . . _:b556070245 . _:b556070464 . _:b556070281 . . _:b556070344 . . _:b556070287 . . . . . _:b556070165 . . _:b556070237 . . _:b556070541 . _:b556070680 . . . . _:b556070554 . . . _:b556070240 . . . . _:b556070227 . _:b556070174 . _:b556070579 . . _:b556070176 . _:b556070608 . _:b556070195 . _:b556070368 . . _:b556070515 . _:b556070311 . _:b556070189 . _:b556070332 . . . _:b32492099 . _:b556070631 . _:b556070661 . _:b556070660 . _:b556070663 . . _:b556070178 . _:b556070662 . . _:b556070613 . _:b556070397 . _:b556070657 . . _:b556070656 . _:b556070659 . _:b556070685 . _:b556070658 . _:b556070669 . _:b556070722 . _:b556070493 . _:b556070472 . . _:b556070668 . _:b556070415 . _:b556070671 . . _:b556070505 . _:b556070670 . _:b556070553 . _:b556070665 . _:b556070523 . _:b556070664 . _:b556070336 . _:b556070710 . . _:b556070667 . . _:b32492099 . . _:b556070667 . _:b556070666 . _:b556070677 . _:b556070676 . . . _:b556070679 . _:b556070678 . _:b556070673 . _:b556070635 . . _:b556070672 . _:b556070675 . _:b556070674 . _:b556070462 . _:b556070685 . . . . _:b556070684 . _:b556070335 . _:b556070687 . . . _:b556070725 . _:b556070686 . _:b556070532 . _:b556070295 . _:b556070681 . _:b556070680 . _:b556070683 . _:b556070682 . _:b556070693 . _:b556070692 . _:b556070695 . _:b556070694 . _:b556070689 . _:b556070688 . _:b556070616 . _:b556070691 . _:b556070690 . _:b556070701 . _:b556070676 . _:b556070700 . . _:b556070225 . _:b556070255 . _:b556070703 . _:b556070702 . _:b556070697 . . _:b556070696 . _:b556070699 . _:b556070474 . _:b556070698 . _:b556070709 . _:b556070252 . . . . _:b556070708 . _:b556070711 . _:b556070710 . _:b556070705 . _:b556070704 . _:b556070428 . _:b556070707 . _:b556070657 . . _:b556070706 . _:b556070717 . _:b556070716 . . _:b556070719 . _:b556070372 . _:b556070718 . _:b556070713 . _:b556070712 . . _:b556070715 . _:b556070714 . _:b556070224 . _:b556070725 . _:b556070529 . _:b556070724 . _:b556070727 . . . _:b556070726 . _:b556070721 . . _:b556070302 . _:b556070720 . _:b556070723 . _:b556070722 . _:b556070732 . . . . _:b556070191 . _:b556070696 . _:b556070729 . . _:b556070636 . _:b556070417 . _:b556070728 . . _:b556070731 . . _:b556070301 . . _:b556070730 . _:b556070292 . . _:b556070622 . . . _:b556070665 . _:b556070320 . . . . . _:b556070671 . . . . . . . _:b32492103 . _:b556070578 . . _:b556070277 . . _:b556070675 . . _:b556070182 . _:b556070314 . . . . _:b556070385 . . . . _:b556070259 . _:b556070327 . . . _:b556070437 . _:b556070273 . . . . . . . . _:b556070642 . . _:b556070402 . _:b556070305 . . . . . _:b556070520 . _:b556070434 . _:b556070373 . _:b556070571 . _:b556070576 . . . _:b556070467 . _:b32492096 "Generally, in bioactive drugs having hydrophobic moieties in their structure and low water solubility, dendrimers are a good choice in the field of efficient delivery system [>>63<<]." . . _:b556070542 . . . _:b556070177 . . . . _:b556070328 . _:b556070390 . _:b556070589 . . _:b556070319 . _:b556070223 . _:b556070351 . _:b556070454 . . . _:b32492091 . _:b556070466 . _:b556070321 . . _:b32492086 . _:b32492084 _:b32492085 . _:b32492084 _:b32492086 . . _:b32492084 _:b32492087 . . . _:b556070389 . _:b556070418 . . _:b32492084 _:b32492092 . _:b32492084 _:b32492093 . _:b556070498 . _:b32492084 _:b32492094 . _:b556070699 . _:b32492084 _:b32492095 . _:b32492084 _:b32492088 . _:b32492084 _:b32492089 . _:b32492084 _:b32492090 . _:b32492084 _:b32492091 . . . _:b556070629 . . . _:b556070714 . . _:b556070461 . . . _:b556070503 . . _:b556070166 . . _:b556070509 . _:b556070535 . _:b556070403 . _:b32492084 _:b32492100 . _:b32492084 _:b32492101 . _:b32492084 _:b32492102 . _:b32492084 _:b32492103 . _:b32492084 _:b32492096 . _:b556070545 . _:b32492084 _:b32492097 . . _:b32492084 _:b32492098 . _:b32492084 _:b32492099 . _:b556070475 . . _:b556070322 . _:b556070655 . _:b556070194 . _:b556070603 . _:b556070534 . _:b556070412 . _:b556070308 . _:b556070383 . . _:b556070614 . _:b556070550 . _:b556070618 . . . . _:b556070447 . _:b32492099 "Dendritic delivery of PDT agents has been investigated within the last few years in order to improve upon tumor selectivity, retention, and pharmacokinetics [>>72<<-75]." . . _:b556070482 . _:b32492087 . . _:b556070501 . . . _:b556070218 . . . _:b556070449 . _:b556070560 . . . _:b556070282 . . . _:b556070703 . _:b556070621 . . _:b32492094 "When these groups are charged, the surface may have as a polyelectrolyte and is likely to electrostatically attract oppositely charged molecules [>>53<<]. One example of electrostatic interactions between polyelectrolyte dendrimers and charged species include the aggregation of methylene blue on the dendrimer surface and the binding of EPR probes such as copper complexes and nitroxide" . _:b32492084 . _:b556070565 . _:b32492085 . _:b556070232 . _:b556070409 . _:b32492086 . _:b556070661 . _:b556070646 . _:b32492087 . _:b556070427 . . _:b556070539 . _:b556070537 . . _:b32492092 . _:b32492093 . . _:b32492094 . . _:b32492095 . _:b556070597 . _:b556070307 . _:b32492088 . . _:b32492089 . _:b32492090 . _:b32492091 . _:b556070518 . _:b32492100 . _:b32492101 . _:b556070256 . . _:b32492102 . . _:b32492103 . _:b556070666 . _:b32492096 . . _:b32492097 . _:b32492098 . _:b32492099 . _:b556070443 . . . . _:b556070271 . _:b556070497 . . _:b556070406 . . . . . _:b556070480 . . . _:b556070573 . _:b556070164 . . _:b556070494 . _:b556070599 . . . _:b32492089 "There continues to be a debate about the exact structure of dendrimers, in particular whether they are fully extended with maximum density at the surface or whether the end-groups fold back into a densely packed interior [21,>>22<<]. Dendrimers can be prepared with a level of control not attainable with most linear polymers, leading to nearly monodisperse, globular macromolecules with a large number of peripheral groups as seen in Figure\u00A02, the structure of some" . . _:b32492097 "However, there is little doubt that genetic therapies will make a significant contribution to our therapeutic armamentarium once some of the key challenges, such as specific and efficient delivery, have been solved [>>64<<]. The ability to deliver pieces of DNA to the required parts of a cell includes many challenges. Current research is being performed to find ways to use dendrimers to traffic genes into cells without damaging or deactivating the DNA. To" . . . _:b556070392 . . _:b32492088 . . _:b556070491 . . _:b556070272 . _:b556070405 . _:b556070404 . _:b556070407 . _:b556070406 . _:b556070401 . _:b556070400 . . _:b556070198 . _:b556070403 . _:b556070513 . _:b556070402 . _:b556070413 . _:b556070412 . _:b556070415 . _:b556070414 . _:b556070409 . _:b556070162 . . _:b556070408 . _:b556070221 . _:b556070411 . _:b556070291 . _:b556070522 . _:b556070410 . _:b556070697 . _:b556070566 . _:b556070421 . . _:b556070514 . _:b556070420 . _:b556070528 . . _:b556070423 . _:b556070580 . _:b556070422 . _:b556070417 . _:b556070416 . _:b556070381 . _:b556070530 . _:b556070419 . . _:b556070418 . _:b556070303 . _:b556070708 . _:b556070429 . . _:b556070428 . . _:b556070431 . . _:b556070430 . _:b556070423 . . _:b556070425 . . . _:b556070424 . _:b556070433 . _:b556070427 . _:b556070511 . _:b556070426 . _:b556070437 . _:b556070455 . _:b556070436 . _:b556070439 . _:b556070438 . _:b556070433 . _:b556070540 . _:b556070432 . _:b556070654 . _:b556070435 . _:b556070434 . . _:b556070445 . . . _:b556070444 . . _:b556070447 . _:b32492093 . _:b556070446 . _:b556070441 . _:b556070436 . _:b556070300 . . . _:b556070607 . _:b556070440 . _:b556070443 . . _:b556070442 . _:b556070453 . _:b556070212 . . _:b556070452 . _:b556070651 . . _:b556070455 . _:b556070648 . _:b556070175 . _:b556070454 . . _:b556070449 . _:b556070448 . _:b556070451 . _:b556070450 . _:b556070562 . _:b556070461 . _:b556070460 . _:b556070463 . _:b556070462 . _:b556070457 . _:b556070456 . _:b556070459 . _:b556070458 . _:b556070469 . _:b32492103 "Furthermore, highly sensitive analytical devices [77,78], MRI contrast agents [79], prion research [80], burn treatment [81], and EPR imaging with spin-labeled dendrimers [>>82<<-106] are some of the diverse areas of fascinating ongoing dendrimer research that are beyond the scope of this article." . _:b556070468 . . . _:b556070471 . _:b556070470 . _:b556070181 . _:b556070555 . _:b556070234 . _:b556070465 . _:b556070464 . _:b556070467 . _:b556070355 . _:b556070466 . _:b556070632 . _:b556070477 . _:b556070476 . _:b556070479 . . . _:b556070478 . _:b556070473 . . _:b556070472 . _:b556070475 . _:b556070474 . . . _:b556070485 . _:b556070623 . _:b556070484 . _:b556070378 . _:b556070487 . _:b556070486 . . _:b556070481 . . _:b556070480 . _:b556070483 . _:b556070720 . _:b556070482 . _:b556070493 . _:b556070492 . _:b556070495 . _:b556070494 . . _:b556070456 . _:b556070489 . _:b556070488 . _:b556070414 . _:b556070491 . _:b556070490 . _:b32492090 . _:b556070501 . _:b556070500 . _:b556070380 . _:b556070503 . _:b556070502 . _:b32492093 . _:b556070497 . _:b556070496 . _:b556070507 . _:b556070633 . _:b556070499 . _:b556070538 . _:b556070498 . . _:b556070509 . _:b556070508 . _:b556070674 . _:b556070511 . _:b556070329 . _:b556070510 . . . _:b556070505 . _:b556070504 . _:b556070507 . . . . . _:b556070506 . . _:b556070517 . . . _:b556070516 . _:b556070274 . . _:b556070519 . . . _:b556070518 . _:b556070297 . _:b556070513 . _:b556070728 . _:b556070512 . . _:b556070382 . _:b556070515 . . . _:b556070514 . _:b556070525 . _:b556070524 . _:b556070637 . _:b556070527 . . . _:b556070526 . . . _:b556070521 . _:b556070520 . _:b32492088 "explicit study of the effects of polymer size, charge, and composition on biologically relevant properties such as lipid bilayer interactions, cytotoxicity, internalization, blood plasma retention time, biodistribution, and filtration [>>19<<] (Figure\u00A01)." . _:b556070523 . _:b556070522 . . _:b556070483 . . _:b556070533 . _:b556070343 . _:b556070698 . . _:b556070532 . _:b556070549 . . _:b556070535 . _:b556070534 . _:b556070166 "8"^^ . _:b556070529 . _:b556070167 "7"^^ . _:b556070161 "16"^^ . _:b556070528 . _:b556070162 "15"^^ . _:b556070164 "9"^^ . _:b556070531 . _:b556070165 "8"^^ . _:b556070530 . _:b556070341 . _:b556070541 . _:b556070163 "9"^^ . _:b556070540 . . . _:b556070543 . . . _:b556070174 "6"^^ . _:b556070542 . _:b556070175 "6"^^ . . _:b556070537 . _:b556070701 . _:b556070172 "6"^^ . _:b556070684 . _:b556070536 . . _:b556070173 "6"^^ . _:b556070539 . _:b556070568 . _:b556070280 . _:b556070424 . . _:b556070538 . _:b556070170 "7"^^ . . _:b556070190 . _:b556070171 "6"^^ . _:b556070549 . . . _:b556070236 . _:b556070548 . _:b556070168 "7"^^ . _:b556070551 . . . . _:b556070169 "7"^^ . _:b556070241 . _:b556070727 . _:b556070550 . _:b556070181 "5"^^ . _:b556070545 . _:b556070180 "5"^^ . _:b556070544 . _:b556070183 "5"^^ . _:b556070547 . _:b556070182 "5"^^ . _:b556070546 . _:b556070177 "5"^^ . _:b556070557 . . _:b556070176 "6"^^ . _:b556070556 . _:b556070179 "5"^^ . . _:b556070559 . . _:b556070721 . . . . _:b556070178 "5"^^ . . . _:b556070405 . _:b556070558 . _:b556070228 . _:b556070189 "4"^^ . _:b556070553 . _:b556070199 . _:b556070188 "4"^^ . _:b556070552 . . _:b556070191 "4"^^ . _:b556070555 . _:b556070190 "4"^^ . . _:b556070554 . _:b556070185 "5"^^ . _:b556070565 . _:b556070184 "5"^^ . _:b556070564 . _:b556070187 "5"^^ . . _:b556070567 . _:b556070186 "5"^^ . _:b556070566 . _:b556070197 "4"^^ . _:b556070561 . _:b556070196 "4"^^ . _:b556070560 . _:b556070199 "4"^^ . . _:b556070563 . . _:b556070198 "4"^^ . _:b556070562 . _:b556070193 "4"^^ . _:b556070573 . _:b556070192 "4"^^ . . _:b556070572 . _:b556070195 "4"^^ . . _:b556070575 . _:b556070184 . _:b556070194 "4"^^ . _:b556070659 . _:b556070470 . _:b556070525 . _:b556070574 . _:b556070205 "4"^^ . _:b556070172 . _:b556070569 . _:b556070204 "4"^^ . _:b556070568 . _:b556070207 "4"^^ . _:b556070682 . . _:b556070360 . _:b556070571 . _:b556070206 "4"^^ . _:b556070731 . _:b556070207 . _:b556070570 . . _:b556070201 "4"^^ . _:b556070581 . _:b556070200 "4"^^ . _:b556070580 . _:b556070203 "4"^^ . _:b556070583 . _:b556070202 "4"^^ . _:b556070582 . _:b556070213 "4"^^ . _:b556070577 . . _:b556070364 . _:b556070212 "4"^^ . _:b556070576 . _:b556070215 "3"^^ . . _:b556070258 . _:b556070579 . _:b556070214 "3"^^ . _:b556070578 . _:b556070209 "4"^^ . _:b556070589 . _:b556070208 "4"^^ . _:b556070262 . _:b556070588 . _:b556070211 "4"^^ . _:b556070261 . _:b556070634 . _:b556070591 . _:b556070210 "4"^^ . _:b556070296 . _:b556070660 . . _:b556070590 . _:b556070221 "3"^^ . _:b556070670 . _:b556070585 . _:b556070220 "3"^^ . . _:b556070584 . _:b556070223 "3"^^ . _:b556070587 . _:b556070222 "3"^^ . _:b556070394 . _:b556070586 . _:b556070217 "3"^^ . _:b556070597 . _:b556070216 "3"^^ . _:b556070596 . _:b556070219 "3"^^ . _:b556070599 . _:b556070218 "3"^^ . _:b556070610 . _:b556070229 "3"^^ . . _:b556070598 . . _:b556070593 . _:b556070228 "3"^^ . . _:b556070168 . _:b556070289 . _:b556070592 . _:b556070231 "3"^^ . _:b556070595 . _:b556070230 "3"^^ . _:b556070594 . _:b556070225 "3"^^ . _:b556070559 . . _:b556070605 . _:b556070224 "3"^^ . . _:b556070485 . _:b556070604 . _:b556070227 "3"^^ . _:b556070354 . _:b556070348 . _:b556070581 . _:b556070607 . _:b556070226 "3"^^ . _:b556070606 . _:b556070237 "3"^^ . . _:b556070601 . _:b556070236 "3"^^ . _:b556070600 . _:b556070239 "3"^^ . . _:b556070603 . _:b556070238 "3"^^ . _:b556070290 . _:b556070602 . _:b556070233 "3"^^ . _:b556070286 . _:b556070613 . _:b556070232 "3"^^ . _:b556070686 . _:b556070264 . _:b556070235 "3"^^ . _:b556070612 . . _:b556070615 . _:b556070234 "3"^^ . _:b556070265 . _:b32492093 "The strategy of coupling small molecules to polymeric scaffolds by covalent linkages to improve their pharmacological properties has been under experimental test for over three decades [>>43<<-46]. In most cases, however, the conjugated dendritic assembly functions as \u2018pro-drug\u2019 where, upon internalization into the target cell, the conjugate must be liberated to activate the drug (Figure\u00A06)." . . _:b556070614 . _:b556070245 "3"^^ . _:b556070672 . _:b556070609 . _:b556070244 "3"^^ . _:b556070516 . . _:b556070608 . _:b556070247 "3"^^ . _:b556070611 . _:b556070246 "3"^^ . _:b556070610 . _:b556070241 "3"^^ . _:b556070621 . _:b556070240 "3"^^ . _:b556070620 . _:b556070243 "3"^^ . _:b556070704 . _:b556070623 . _:b556070242 "3"^^ . _:b556070500 . _:b556070622 . _:b556070253 "3"^^ . . _:b556070617 . _:b556070252 "3"^^ . _:b556070616 . _:b556070255 "3"^^ . _:b556070619 . _:b556070254 "3"^^ . _:b556070408 . _:b556070618 . _:b556070249 "3"^^ . _:b556070629 . _:b556070248 "3"^^ . . _:b556070628 . _:b556070251 "3"^^ . . _:b556070631 . _:b556070250 "3"^^ . _:b556070683 . _:b556070630 . _:b556070261 "3"^^ . . _:b556070625 . . _:b556070260 "3"^^ . . _:b556070624 . _:b556070263 "3"^^ . . _:b556070561 . _:b556070652 . _:b556070627 . _:b556070262 "3"^^ . _:b556070692 . _:b556070626 . _:b556070257 "3"^^ . _:b556070217 . _:b556070637 . _:b556070256 "3"^^ . _:b556070636 . _:b556070259 "3"^^ . _:b556070269 . _:b556070639 . _:b556070258 "3"^^ . _:b556070638 . _:b556070269 "3"^^ . _:b556070633 . _:b556070268 "3"^^ . _:b556070625 . _:b556070271 "3"^^ . _:b556070632 . _:b556070635 . _:b556070270 "3"^^ . _:b556070471 . _:b556070634 . _:b556070265 "3"^^ . _:b556070645 . _:b556070264 "3"^^ . _:b556070644 . _:b556070267 "3"^^ . _:b556070440 . _:b32492085 . _:b556070647 . _:b556070266 "3"^^ . _:b556070202 . _:b556070646 . _:b556070277 "3"^^ . _:b556070641 . _:b556070200 . _:b556070276 "3"^^ . _:b556070640 . _:b556070279 "3"^^ . _:b556070611 . _:b556070643 . _:b556070278 "3"^^ . _:b556070642 . _:b556070273 "3"^^ . _:b556070222 . _:b556070653 . _:b556070272 "3"^^ . . _:b556070652 . _:b556070275 "3"^^ . _:b556070655 . _:b556070274 "3"^^ . _:b556070285 "2"^^ . _:b556070654 . _:b556070284 "2"^^ . _:b556070649 . _:b556070287 "2"^^ . _:b556070648 . _:b556070577 . . _:b556070286 "2"^^ . _:b556070651 . _:b556070294 . . _:b556070650 . _:b556070281 "3"^^ . . _:b556070280 "3"^^ . _:b556070283 "2"^^ . . _:b556070315 . _:b556070420 . _:b556070282 "3"^^ . _:b556070235 . _:b556070293 "2"^^ . _:b556070292 "2"^^ . _:b556070713 . _:b556070295 "2"^^ . . _:b556070294 "2"^^ . . _:b556070289 "2"^^ . _:b556070288 "2"^^ . _:b556070490 . _:b556070291 "2"^^ . . _:b556070290 "2"^^ . _:b556070301 "2"^^ . _:b556070300 "2"^^ . _:b556070647 . _:b556070303 "2"^^ . _:b556070302 "2"^^ . _:b556070338 . _:b556070297 "2"^^ . . _:b556070296 "2"^^ . . _:b556070165 . _:b556070299 "2"^^ . _:b556070164 . _:b556070681 . _:b556070298 "2"^^ . _:b556070167 . . _:b556070650 . _:b556070309 "2"^^ . _:b556070166 . _:b556070229 . _:b556070308 "2"^^ . . _:b556070161 . _:b556070311 "2"^^ . _:b556070310 "2"^^ . _:b556070163 . . _:b556070305 "2"^^ . _:b556070162 . _:b556070304 "2"^^ . _:b556070173 . _:b556070307 "2"^^ . _:b556070251 . _:b556070172 . . _:b556070306 "2"^^ . _:b556070175 . _:b556070317 "2"^^ . _:b556070174 . _:b556070316 "2"^^ . . _:b556070169 . _:b556070319 "2"^^ . _:b556070168 . _:b556070318 "2"^^ . _:b556070171 . . . _:b556070313 "2"^^ . _:b556070170 . _:b556070312 "2"^^ . _:b556070181 . _:b556070711 . _:b556070315 "2"^^ . _:b556070180 . . _:b556070314 "2"^^ . _:b556070183 . _:b556070668 . _:b556070325 "2"^^ . _:b556070182 . . _:b32492085 "Dendrimers might also be called \u2018cascade molecules\u2019\u2009, but this term is not as much established as \u2018dendrimers\u2019 [>>2<<-4]. Dendrimers are nearly monodisperse macromolecules that contain symmetric branching units built around a small molecule or a linear polymer core [5-7]. \u2018Dendrimer\u2019 is only an architectural motif and not a compound. Polyionic dendrimers" . _:b556070324 "2"^^ . _:b556070177 . . _:b556070517 . _:b556070327 "2"^^ . _:b556070176 . . . _:b556070407 . . _:b556070326 "2"^^ . _:b556070179 . _:b556070536 . _:b556070321 "2"^^ . _:b556070178 . _:b556070320 "2"^^ . _:b556070189 . . _:b556070323 "2"^^ . _:b556070188 . _:b556070322 "2"^^ . _:b556070191 . . _:b556070333 "2"^^ . _:b556070190 . . _:b556070363 . _:b556070332 "2"^^ . _:b556070185 . _:b556070422 . _:b556070588 . _:b556070335 "2"^^ . _:b556070184 . _:b556070334 "2"^^ . _:b556070187 . . . _:b556070329 "2"^^ . _:b556070186 . _:b556070328 "2"^^ . _:b556070197 . . _:b556070331 "2"^^ . _:b556070196 . _:b556070346 . _:b556070330 "2"^^ . _:b556070199 . _:b556070724 . _:b556070715 . _:b556070341 "2"^^ . _:b556070198 . _:b556070340 "2"^^ . . _:b556070193 . . _:b556070343 "2"^^ . _:b556070192 . . _:b556070342 "2"^^ . _:b556070195 . _:b556070163 . _:b556070337 "2"^^ . _:b556070194 . _:b556070336 "2"^^ . _:b556070205 . _:b556070339 "2"^^ . _:b556070204 . _:b556070338 "2"^^ . _:b556070207 . _:b556070349 "2"^^ . _:b556070206 . . _:b556070348 "2"^^ . _:b556070201 . . _:b556070351 "2"^^ . _:b32492099 . _:b556070200 . _:b556070693 . _:b556070350 "2"^^ . _:b556070203 . . _:b556070345 "2"^^ . _:b556070202 . . _:b556070344 "2"^^ . _:b556070213 . . . _:b556070347 "2"^^ . _:b556070212 . _:b556070285 . . _:b556070346 "2"^^ . _:b556070215 . . . _:b556070376 . _:b556070624 . _:b556070357 "2"^^ . _:b556070214 . _:b556070356 "2"^^ . _:b556070209 . _:b556070359 "2"^^ . _:b556070208 . _:b556070358 "2"^^ . _:b556070211 . _:b556070663 . _:b556070353 "2"^^ . _:b556070210 . . _:b556070352 "2"^^ . _:b556070221 . _:b556070355 "2"^^ . _:b556070220 . _:b556070439 . . _:b556070354 "2"^^ . _:b556070223 . _:b556070365 "2"^^ . _:b556070222 . _:b556070364 "2"^^ . _:b556070217 . . _:b556070367 "2"^^ . _:b556070216 . . _:b556070366 "2"^^ . _:b556070244 . . _:b556070219 . _:b556070361 "2"^^ . _:b556070218 . . _:b556070360 "2"^^ . _:b556070677 . . _:b556070229 . _:b556070363 "2"^^ . _:b556070228 . _:b556070208 . _:b556070688 . _:b556070362 "2"^^ . _:b556070231 . _:b556070373 "2"^^ . _:b556070230 . _:b556070372 "2"^^ . _:b556070225 . _:b556070375 "2"^^ . _:b556070224 . _:b556070719 . _:b556070374 "2"^^ . _:b556070227 . _:b556070369 "2"^^ . _:b556070226 . _:b556070368 "2"^^ . _:b556070237 . . _:b556070371 "2"^^ . _:b556070236 . _:b556070370 "2"^^ . _:b556070239 . _:b556070381 "2"^^ . . _:b556070238 . . _:b556070380 "2"^^ . _:b556070233 . _:b556070478 . _:b556070383 "2"^^ . _:b556070574 . _:b556070232 . _:b556070382 "2"^^ . _:b556070235 . _:b556070377 "2"^^ . . _:b556070234 . . _:b556070376 "2"^^ . _:b556070245 . . _:b556070379 "2"^^ . . _:b556070244 . _:b556070333 . _:b556070378 "2"^^ . _:b556070247 . . _:b556070389 "2"^^ . _:b556070246 . _:b556070388 "2"^^ . _:b556070241 . . . . _:b556070391 "2"^^ . _:b556070240 . _:b556070365 . _:b32492101 . _:b556070390 "2"^^ . _:b556070243 . _:b556070527 . _:b556070533 . _:b556070362 . _:b556070183 . _:b556070385 "2"^^ . _:b556070299 . _:b556070242 . _:b556070384 "2"^^ . . _:b556070687 . _:b556070253 . _:b556070387 "2"^^ . _:b556070252 . _:b556070386 "2"^^ . _:b556070210 . _:b556070255 . . _:b556070397 "2"^^ . _:b556070254 . _:b556070396 "2"^^ . _:b556070249 . . _:b556070399 "2"^^ . . _:b556070248 . _:b32492101 "Furthermore, highly sensitive analytical devices [77,78], MRI contrast agents [79], prion research [>>80<<], burn treatment [81], and EPR imaging with spin-labeled dendrimers [82-106] are some of the diverse areas of fascinating ongoing dendrimer research that are beyond the scope of this article." . _:b556070398 "2"^^ . _:b556070251 . _:b556070393 "2"^^ . _:b556070250 . _:b556070279 . _:b556070392 "2"^^ . _:b556070261 . _:b556070593 . _:b556070395 "2"^^ . _:b556070260 . . _:b556070379 . _:b556070394 "2"^^ . . _:b556070263 . _:b556070705 . _:b556070310 . _:b556070546 . _:b556070262 . _:b556070257 . _:b556070256 . . _:b556070259 . _:b556070258 . _:b556070269 . . _:b556070268 . . _:b556070271 . _:b556070640 . _:b556070606 . . _:b556070270 . . _:b556070366 . _:b556070265 . _:b556070264 . . _:b556070267 . _:b556070266 . . _:b556070277 . _:b556070215 . _:b556070276 . _:b556070279 . _:b556070278 . _:b556070273 . _:b556070272 . . _:b556070275 . _:b556070268 . _:b556070173 . _:b556070274 . . _:b556070285 . _:b556070284 . _:b556070247 . _:b556070287 . _:b556070506 . _:b556070286 . _:b556070575 . _:b32492103 . _:b556070281 . _:b556070712 . _:b556070280 . . . _:b556070283 . _:b556070282 . . _:b556070293 . . _:b556070292 . _:b32492084 . _:b556070295 . _:b556070371 . _:b556070294 . _:b556070450 . _:b556070289 . _:b556070167 . _:b556070552 . _:b556070288 . . . _:b556070291 . . _:b556070290 . _:b556070301 . _:b32492084 "review" . _:b556070300 . _:b556070303 . . _:b556070302 . . . _:b556070297 . _:b556070170 . _:b556070296 . _:b556070299 . _:b556070298 . _:b32492099 . . _:b556070615 . _:b556070309 . _:b556070171 . _:b556070308 . . . . _:b556070311 . . . . _:b556070310 . . _:b556070305 . . _:b556070359 . _:b556070645 . _:b556070304 . _:b556070557 . _:b556070307 . . . . _:b556070306 . _:b556070317 . _:b556070316 . . _:b556070479 . _:b556070319 . . . _:b556070318 . . _:b556070313 . _:b556070312 . _:b556070315 . . _:b556070314 . _:b556070325 . . _:b556070324 . _:b556070327 . _:b556070326 . . . . _:b556070321 . . _:b556070320 . _:b556070323 . _:b556070219 . _:b556070322 . . . . . _:b556070333 . _:b556070332 . _:b556070678 . _:b556070335 . . _:b556070334 . _:b556070204 . _:b556070329 . . _:b556070328 . _:b556070476 . _:b556070331 . _:b556070330 . _:b556070393 . _:b556070341 . _:b556070350 . _:b556070340 . _:b556070267 . _:b556070343 . . . _:b556070369 . _:b556070342 . _:b556070564 . _:b556070337 . _:b556070336 . _:b556070339 . _:b556070338 . _:b32492100 "Furthermore, highly sensitive analytical devices [77,78], MRI contrast agents [>>79<<], prion research [80], burn treatment [81], and EPR imaging with spin-labeled dendrimers [82-106] are some of the diverse areas of fascinating ongoing dendrimer research that are beyond the scope of this article." . _:b556070349 . _:b556070442 . _:b556070348 . _:b556070463 . _:b32492098 "Research has shown that the fast-degrading functional polymer has great potential for localized transfection [>>65<<-67]." . . _:b556070351 . _:b556070350 . _:b556070345 . _:b556070344 . . _:b556070318 . _:b556070590 . _:b556070347 . _:b556070197 . _:b556070346 . _:b556070583 . _:b556070357 . _:b556070356 . _:b556070359 . . _:b556070358 . _:b556070242 . _:b556070196 . _:b556070353 . _:b556070679 . _:b556070352 . . _:b556070283 . _:b556070355 . _:b556070617 . . _:b556070354 . _:b556070365 . _:b556070364 . _:b556070367 . . _:b556070366 . _:b556070510 . _:b556070361 . _:b556070360 . _:b556070363 . . . . _:b556070362 . _:b556070248 . _:b556070586 . _:b556070373 . _:b556070372 . _:b556070619 . _:b556070375 . _:b556070266 . _:b556070374 . _:b556070369 . _:b556070367 . . _:b556070368 . . _:b556070371 . _:b556070370 . . . _:b556070381 . . _:b556070380 . . _:b556070383 . _:b556070524 . _:b556070382 . _:b556070465 . _:b556070591 . . _:b556070460 . _:b556070377 . _:b556070431 . _:b556070376 . . _:b556070379 . . _:b556070378 . . _:b556070389 . . _:b556070388 . _:b556070391 . _:b556070584 . _:b556070390 . . _:b556070385 . _:b556070628 . _:b556070426 . _:b556070448 . _:b556070384 . _:b556070387 . _:b556070386 . . _:b556070521 . . . _:b556070397 . . . _:b556070396 . . . _:b556070399 . . _:b556070398 . _:b556070393 . _:b556070392 . . _:b556070395 . _:b556070356 . _:b556070429 . _:b556070394 . _:b556070690 . _:b556070250 .