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_:b558155962 . . . _:b558155963 . _:b558155940 . _:b558154271 . . _:b558155941 . _:b33181486 . _:b558155237 "2"^^ . _:b558155942 . _:b558155943 . . _:b558155936 . _:b558154270 . _:b558155937 . _:b558155236 "2"^^ . _:b558148534 . _:b558155938 . _:b558155939 . _:b558155948 . _:b558154265 . _:b558155949 . _:b558155239 "2"^^ . _:b558155950 . _:b558155951 . _:b558155944 . _:b558154264 . _:b558155945 . _:b558155238 "2"^^ . _:b558155946 . _:b558155947 . _:b558149754 . _:b558154267 . . _:b558155233 "2"^^ . _:b558152715 . _:b558154266 . . _:b558155232 "2"^^ . _:b558154277 . _:b558155235 "2"^^ . _:b558154276 . _:b558155626 . _:b558155234 "2"^^ . . . _:b558152340 . _:b558154279 . _:b558155245 "2"^^ . . _:b558154278 . _:b558155244 "2"^^ . _:b558154273 . _:b558155247 "2"^^ . _:b558154272 . _:b558155246 "2"^^ . . _:b558154275 . . _:b558155241 "2"^^ . _:b558150828 . _:b558154274 . _:b558155240 "2"^^ . . _:b558155675 . _:b558154285 . . _:b558155243 "2"^^ . _:b558154284 . _:b558155242 "2"^^ . . 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_:b558155214 . _:b558154243 "2"^^ . . _:b558154308 . . _:b558154242 "2"^^ . _:b558154311 . _:b558154253 "2"^^ . _:b558154310 . _:b558154252 "2"^^ . _:b558154305 . _:b558154255 "2"^^ . . _:b558154304 . _:b558149148 . _:b558154254 "2"^^ . _:b558150362 . . _:b558154307 . _:b558154249 "2"^^ . . . _:b558154306 . _:b558154248 "2"^^ . . _:b558154317 . _:b558154251 "2"^^ . _:b558153615 . _:b558149903 . _:b558154316 . _:b558154250 "2"^^ . . _:b558154319 . _:b558154261 "2"^^ . _:b558154318 . . _:b558154260 "2"^^ . _:b558150917 . _:b558154313 . . _:b558154263 "2"^^ . _:b558148797 . . _:b558154312 . . _:b558154262 "2"^^ . . . _:b558154315 . . _:b558154257 "2"^^ . . _:b558155774 . _:b558154314 . . _:b558154256 "2"^^ . . _:b558154325 . _:b558152207 . _:b558154259 "2"^^ . _:b558151608 . _:b558149205 . _:b558154324 . . _:b558155760 . _:b558154258 "2"^^ . . _:b558154892 . _:b558154327 . _:b558154269 "2"^^ . _:b558149912 . _:b558154326 . _:b558154268 "2"^^ . _:b558154144 . _:b558154321 . _:b558153497 . 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_:b558154350 . _:b558154292 "2"^^ . _:b558149817 . . . . _:b558154345 . _:b558154295 "2"^^ . _:b558154344 . _:b558150082 . _:b558154294 "2"^^ . . . _:b558154347 . _:b558154289 "2"^^ . _:b558154346 . _:b558154288 "2"^^ . _:b558154357 . _:b558154291 "2"^^ . . _:b558154356 . _:b558154290 "2"^^ . _:b558154359 . . _:b558154301 "2"^^ . . _:b558154358 . _:b558154300 "2"^^ . _:b558152446 . . _:b558154353 . _:b558154303 "2"^^ . _:b558154352 . _:b558154815 . _:b558154302 "2"^^ . _:b558153365 . _:b558154355 . _:b558154297 "2"^^ . _:b558154354 . _:b558154296 "2"^^ . _:b558154365 . _:b558154299 "2"^^ . _:b558153521 . _:b558154364 . . _:b558154298 "2"^^ . _:b558148428 . _:b558154367 . _:b558154309 "2"^^ . _:b558154366 . . _:b558154308 "2"^^ . . _:b558155687 . _:b558149885 . _:b558154361 . . _:b558154311 "2"^^ . . _:b558154360 . . _:b558154310 "2"^^ . . _:b558151841 . _:b558149374 . _:b558154363 . _:b558154305 "2"^^ . . _:b558154362 . _:b558155090 . _:b558154304 "2"^^ . _:b558154373 . _:b558154307 "2"^^ . . . _:b558154372 . . _:b558154306 "2"^^ . _:b558149275 . _:b558150921 . _:b558154375 . _:b558154317 "2"^^ . . _:b558154374 . _:b558154316 "2"^^ . _:b558154369 . _:b558154319 "2"^^ . _:b558154368 . _:b558153039 . _:b558154318 "2"^^ . . _:b558155051 . . _:b558154371 . _:b558154313 "2"^^ . _:b558154370 . _:b558154312 "2"^^ . . . . _:b558154381 . . _:b558154315 "2"^^ . _:b558154380 . _:b558152129 . _:b558154314 "2"^^ . _:b558154383 . _:b558154325 "2"^^ . _:b558152406 . _:b558154382 . _:b558154324 "2"^^ . _:b558154377 . . _:b558154327 "2"^^ . _:b558150410 . . _:b558154376 . _:b558154326 "2"^^ . . _:b558154379 . . _:b558154321 "2"^^ . _:b558154378 . _:b558154320 "2"^^ . . _:b558154389 . _:b558154323 "2"^^ . _:b558149755 . _:b558154388 . _:b558153690 . _:b558154322 "2"^^ . . _:b558154391 . _:b558154333 "2"^^ . _:b558148371 . _:b558154390 . _:b33181486 "1). All major histologic types of lung adenocarcinoma were represented: 5% lepidic, 33% acinar, 9% papillary, 14% micropapillary, 25% solid, 4% invasive mucinous, 0.4% colloid and 8% unclassifiable adenocarcinoma (Supplementary Fig. 1)>>14<<. Median follow-up was 19 months, and 163 patients were alive at the time of last follow-up." . . _:b558154332 "2"^^ . _:b558154385 . _:b558154335 "2"^^ . . _:b558155056 . _:b558154384 . _:b558154334 "2"^^ . _:b558154387 . . _:b558154329 "2"^^ . . _:b558154386 . . _:b558154328 "2"^^ . _:b558154397 . _:b558155859 . . _:b558154331 "2"^^ . _:b558154396 . _:b558152418 . _:b558154330 "2"^^ . . _:b558153936 . _:b558154399 . _:b558154341 "2"^^ . _:b558149881 . _:b558154398 . _:b558154340 "2"^^ . _:b558154393 . _:b558154343 "2"^^ . . _:b558152307 . _:b558154392 . . _:b558154342 "2"^^ . _:b558150060 . . _:b558154395 . _:b558154337 "2"^^ . _:b558154394 . . _:b558154336 "2"^^ . _:b558148713 . _:b558154405 . _:b558154339 "2"^^ . _:b558148648 . . _:b558154404 . _:b558154338 "2"^^ . _:b558154407 . _:b558154349 "2"^^ . . _:b558154406 . _:b558154348 "2"^^ . _:b558154464 . . . _:b558154401 . _:b558154351 "2"^^ . _:b558154400 . _:b558154350 "2"^^ . . _:b558149259 . _:b558154403 . _:b558154345 "2"^^ . 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. . _:b558154425 . _:b558154375 "2"^^ . . _:b558154424 . _:b558154374 "2"^^ . _:b558154427 . _:b558154369 "2"^^ . _:b558152537 . . _:b558154426 . . _:b558154368 "2"^^ . _:b558153608 . _:b558154437 . _:b558154371 "2"^^ . _:b558154436 . _:b558154370 "2"^^ . . _:b558153247 . . . _:b558154439 . _:b558154381 "2"^^ . _:b558150112 . _:b558149032 . _:b558154438 . _:b558154380 "2"^^ . _:b558154433 . _:b558154383 "2"^^ . . _:b558154432 . _:b558154382 "2"^^ . _:b558154435 . _:b558154377 "2"^^ . _:b558149841 . . _:b558152886 . _:b558154434 . _:b558154376 "2"^^ . . . _:b558154445 . . _:b558154379 "2"^^ . . _:b558154444 . _:b558154378 "2"^^ . . _:b558150332 . . . _:b558154447 . _:b558154389 "2"^^ . _:b558152051 . . _:b558154446 . _:b558152282 . _:b558154388 "2"^^ . _:b558154441 . _:b558154391 "2"^^ . _:b558154440 . _:b558154390 "2"^^ . _:b558155360 . _:b558154443 . _:b558154385 "2"^^ . _:b558149189 . . _:b558154442 . _:b558153630 . _:b558154384 "2"^^ . . . . _:b558155847 . _:b558154453 . 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"2"^^ . _:b558154722 . _:b558154723 . _:b558154732 . _:b558154057 . _:b558154733 . _:b558154519 "2"^^ . _:b558154734 . _:b558154735 . _:b558154728 . _:b558154056 . _:b558154729 . _:b558154518 "2"^^ . _:b558154730 . . _:b558154731 . _:b558154644 . _:b558154059 . _:b558154645 . _:b558154513 "2"^^ . _:b558154646 . _:b558154647 . _:b558154640 . _:b558154058 . _:b558153579 . . _:b558154641 . _:b558154512 "2"^^ . _:b558154642 . _:b558154643 . _:b558154652 . _:b558154069 . _:b558154653 . _:b558154515 "2"^^ . _:b558154654 . _:b558149990 . _:b558154655 . _:b558150412 . _:b558154648 . _:b558155518 . _:b558154068 . . _:b558154649 . _:b558154514 "2"^^ . _:b558154650 . _:b558154651 . _:b558154628 . _:b558154071 . _:b558154629 . _:b558154525 "2"^^ . _:b558154630 . _:b558154631 . _:b558156215 . _:b558154624 . _:b558154070 . . . _:b558154625 . _:b558154524 "2"^^ . _:b558154626 . _:b558154627 . _:b558154636 . _:b558154065 . _:b558154637 . _:b558154527 "2"^^ . _:b558154638 . . _:b558154639 . _:b558154632 . _:b558154064 . _:b558154633 . _:b558154526 "2"^^ . _:b558154634 . _:b558154635 . _:b558154676 . _:b558154067 . _:b558150156 . _:b558154677 . _:b558154521 "2"^^ . _:b558154678 . . _:b558154679 . _:b558149445 . . _:b558154672 . _:b558154066 . . _:b558154673 . _:b33181526 "Our results confirm a prior report>>40<< and provide additional insights into this epigenetic program." . _:b558154520 "2"^^ . . _:b558154674 . _:b558154675 . _:b558154684 . _:b558154077 . _:b558153336 . _:b558148367 . _:b558154523 "2"^^ . . _:b558154685 . _:b558154686 . _:b558154687 . _:b558154680 . _:b558154076 . _:b558154681 . _:b558154522 "2"^^ . . _:b558154682 . _:b558154940 . _:b558154683 . _:b558154660 . _:b558154079 . _:b558150227 . _:b558154661 . _:b558154533 "2"^^ . _:b558154662 . _:b558154663 . _:b558154656 . _:b558154078 . _:b558150450 . . _:b558154657 . _:b558154532 "2"^^ . _:b558154658 . . _:b558154659 . _:b558154668 . _:b558154073 . _:b558154669 . _:b558154535 "2"^^ . _:b558154670 . 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. _:b558154459 . _:b558154436 . _:b558154119 . . _:b558154573 "2"^^ . _:b558154437 . _:b558154438 . . _:b558154439 . _:b558154432 . _:b558154118 . _:b558154433 . _:b558154572 "2"^^ . _:b558154434 . _:b558154435 . _:b558154444 . _:b558154480 . _:b558154113 . _:b558154445 . _:b558154575 "2"^^ . _:b558149449 . _:b558154446 . _:b558154447 . _:b558154440 . _:b558154112 . _:b558154441 . _:b558154574 "2"^^ . _:b558154442 . . _:b558154443 . _:b558154484 . _:b558154115 . _:b558152300 . _:b558154485 . _:b558154569 "2"^^ . . _:b558154486 . _:b558154487 . _:b558154480 . _:b558154114 . _:b558154481 . _:b558154568 "2"^^ . _:b558154482 . _:b558152917 . _:b558154483 . _:b558154492 . _:b558154125 . _:b558154493 . _:b558154571 "2"^^ . _:b558154494 . _:b558154495 . _:b558154488 . _:b558154124 . _:b558154489 . _:b558154570 "2"^^ . _:b558154490 . _:b558154491 . _:b558152161 . . _:b558154468 . _:b558154127 . _:b558151898 . _:b558154469 . _:b558154581 "2"^^ . _:b558154470 . _:b558153612 . . . _:b558154471 . 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_:b558154591 "2"^^ . _:b558154382 . _:b558153501 . _:b558154383 . _:b558154376 . _:b558154128 . _:b558154377 . _:b558154590 "2"^^ . . _:b558154378 . . _:b558154379 . _:b558154420 . _:b558154131 . _:b558154421 . _:b558154585 "2"^^ . _:b558150340 . _:b558154422 . _:b558154423 . . _:b558154130 . _:b558154416 . _:b558154417 . _:b558155180 . _:b558154584 "2"^^ . _:b558151064 . _:b558154418 . _:b558154419 . _:b558154428 . _:b558155388 . _:b558154141 . . _:b558154429 . _:b558154587 "2"^^ . . . _:b558154430 . _:b558154431 . _:b558154424 . _:b558154140 . _:b558154425 . _:b558154586 "2"^^ . _:b558154426 . _:b558154427 . _:b558149825 . _:b558154143 . _:b558154404 . _:b558154405 . _:b558154597 "2"^^ . _:b558150473 . _:b558148955 . _:b558155503 . _:b558154406 . _:b558154407 . _:b558154400 . _:b558154142 . _:b558154401 . _:b558154596 "2"^^ . . _:b558151582 . _:b558154402 . _:b558154403 . _:b558154412 . _:b558154137 . _:b558154413 . _:b558154599 "2"^^ . _:b558154414 . _:b558155072 . _:b558154415 . _:b33181498 "We found RB1 mutations in transversion-low adenocarcinomas were enriched for frameshift indels versus single nucleotide substitutions compared to SCLC (P <0.05)>>20<<,21 suggesting a mutational mechanism in transversion-low adenocarcinoma that is probably distinct from smoking in SCLC." . _:b558154408 . _:b558154136 . _:b558154409 . _:b558155364 . _:b558154598 "2"^^ . _:b558154410 . _:b558152388 . _:b558154411 . _:b558154950 . . _:b558154068 . _:b558154139 . _:b558154069 . _:b558154593 "2"^^ . _:b558154070 . _:b558154071 . _:b558155381 . _:b558154064 . _:b558154138 . _:b558154065 . _:b558154592 "2"^^ . _:b558154066 . _:b558154067 . _:b558154076 . _:b558154149 . _:b558148459 . _:b558154077 . _:b558154595 "2"^^ . _:b558154078 . _:b558154079 . _:b558154072 . _:b558154598 . _:b558154148 . . _:b558154594 "2"^^ . _:b558154073 . _:b558154074 . _:b558154075 . _:b558154052 . _:b558154151 . _:b558150819 . _:b558148479 . _:b558154053 . _:b558154605 "2"^^ . _:b558154054 . _:b558154055 . _:b558154048 . _:b558154150 . _:b558154049 . _:b558154604 "2"^^ . _:b558154050 . _:b558154051 . _:b558154060 . _:b558154145 . _:b558154061 . _:b558154607 "2"^^ . _:b558154062 . _:b558154063 . _:b558155915 . _:b558154056 . _:b558154144 . _:b558154057 . _:b558154606 "2"^^ . _:b558150624 . _:b558154058 . _:b558154059 . _:b558154100 . _:b558154147 . _:b558154101 . _:b558154601 "2"^^ . _:b558154102 . _:b558154103 . _:b558154096 . _:b558154146 . . _:b558154600 "2"^^ . _:b558154097 . _:b558154098 . _:b558154099 . . _:b558154157 . _:b558154108 . _:b558154109 . _:b558155054 . _:b558154603 "2"^^ . _:b558154110 . _:b558151173 "3"^^ . . . _:b558154111 . . _:b558154156 . _:b558154104 . _:b558154105 . _:b558154602 "2"^^ . . _:b558154106 . _:b558153971 . _:b558148364 . _:b558154107 . _:b558151172 "3"^^ . _:b558154084 . _:b558154159 . _:b558154085 . _:b558154613 "2"^^ . . _:b558154086 . _:b558153271 . _:b558151175 "3"^^ . . _:b558154087 . _:b558154080 . _:b558154158 . _:b558154081 . _:b558154612 "2"^^ . . _:b558154082 . _:b558151174 "3"^^ . _:b558154083 . _:b558154092 . _:b558154153 . _:b558154093 . _:b558154615 "2"^^ . . _:b558154094 . _:b558151169 "3"^^ . _:b558154095 . _:b558154088 . _:b558154152 . _:b558154089 . _:b558154614 "2"^^ . _:b558151344 . . _:b558154090 . _:b558151168 "3"^^ . _:b558154091 . _:b558154004 . _:b558154155 . . _:b558154609 "2"^^ . _:b558154005 . _:b558154006 . _:b558151171 "3"^^ . _:b558154007 . _:b558154000 . _:b558154154 . _:b558154001 . _:b558154608 "2"^^ . _:b558154002 . _:b558151170 "3"^^ . _:b558154003 . _:b558154012 . _:b558154165 . _:b558154013 . _:b558154611 "2"^^ . _:b558154014 . _:b558151181 "3"^^ . . _:b558154015 . _:b558154008 . _:b558154164 . _:b558154009 . _:b558154610 "2"^^ . . _:b558154010 . _:b558151180 "3"^^ . _:b558154011 . _:b558153988 . _:b558154167 . _:b558153989 . _:b558154621 "2"^^ . _:b558153990 . _:b558155000 . _:b558151183 "3"^^ . . _:b558153991 . _:b558153984 . _:b558154166 . _:b558153985 . _:b558154620 "2"^^ . _:b558153986 . _:b558151182 "3"^^ . _:b558153987 . _:b558153996 . _:b558155517 . _:b558154161 . . _:b558154623 "2"^^ . . _:b558153997 . _:b558153998 . _:b558151177 "3"^^ . _:b558153999 . _:b558153992 . _:b558154160 . _:b558153993 . _:b558154622 "2"^^ . _:b558153994 . _:b558151176 "3"^^ . _:b558153995 . _:b558154036 . _:b558154163 . _:b558154037 . _:b558154617 "2"^^ . . _:b558154038 . . _:b558151179 "3"^^ . _:b558154039 . _:b558154032 . _:b558154162 . . _:b558154033 . _:b558154616 "2"^^ . . _:b558154034 . _:b558151178 "3"^^ . _:b558154035 . _:b558154044 . _:b558154173 . _:b558154045 . _:b558154619 "2"^^ . _:b558149007 . _:b558154046 . _:b558151189 "3"^^ . _:b558154047 . _:b558154040 . _:b558154172 . _:b558154041 . _:b558154618 "2"^^ . . . _:b558154042 . _:b558151188 "3"^^ . _:b558155826 . _:b558150793 . _:b558154043 . _:b558154020 . _:b558154175 . _:b558154021 . _:b558154629 "2"^^ . _:b558154022 . _:b558151191 "3"^^ . _:b558148639 . _:b558154023 . _:b558154016 . _:b558154174 . _:b558154017 . _:b558154628 "2"^^ . _:b558154018 . . _:b558151190 "3"^^ . _:b558154019 . _:b558154028 . _:b558154169 . _:b558154029 . _:b558154631 "2"^^ . _:b558154030 . _:b558151185 "3"^^ . _:b558154031 . _:b558154024 . _:b558154168 . . _:b558154630 "2"^^ . _:b558154025 . _:b558154026 . . _:b558151184 "3"^^ . _:b558154027 . _:b558154196 . _:b558154171 . . _:b558154197 . _:b558154625 "2"^^ . _:b558154198 . _:b558151187 "3"^^ . _:b558154199 . _:b558154192 . _:b558154170 . . _:b558154193 . _:b558154624 "2"^^ . _:b558153915 . _:b558154194 . . _:b558151186 "3"^^ . _:b558154195 . _:b558154204 . _:b558154181 . _:b558154205 . _:b558154627 "2"^^ . _:b558154206 . _:b558151197 "3"^^ . . _:b558154207 . _:b558154200 . _:b558154180 . _:b558154201 . _:b558154626 "2"^^ . _:b558154202 . _:b558151196 "3"^^ . _:b558154203 . _:b558154180 . _:b558154183 . _:b558154181 . _:b558154637 "2"^^ . _:b558154182 . . _:b558151199 "3"^^ . _:b558154183 . _:b558154176 . _:b558154182 . _:b558154177 . _:b558154636 "2"^^ . _:b558154178 . _:b558151198 "3"^^ . _:b558154179 . _:b558154188 . _:b558154177 . _:b558154189 . _:b558154639 "2"^^ . _:b558154190 . _:b558151193 "3"^^ . _:b558154191 . _:b558154184 . _:b558154176 . _:b558154185 . _:b558155572 . _:b558154638 "2"^^ . _:b558150726 . _:b558154186 . _:b558151192 "3"^^ . _:b558154187 . _:b558154228 . _:b558154179 . . _:b558154633 "2"^^ . _:b558151684 . _:b558154229 . _:b558154230 . _:b558151195 "3"^^ . _:b558154231 . _:b558154224 . _:b558154178 . _:b558154225 . _:b558154632 "2"^^ . _:b558154226 . . _:b558150499 . _:b558154227 . _:b558151194 "3"^^ . _:b558154236 . _:b558154189 . _:b558154237 . _:b558154635 "2"^^ . _:b558154238 . _:b558151205 "3"^^ . _:b558154239 . _:b558154232 . _:b558154188 . _:b558154233 . _:b558154634 "2"^^ . _:b558154234 . _:b558156310 . _:b558151204 "3"^^ . _:b558154235 . _:b558154212 . _:b558154191 . _:b558154213 . _:b558154645 "2"^^ . . . _:b558154214 . _:b558151207 "3"^^ . _:b558154215 . _:b558154208 . _:b558154190 . _:b558154209 . _:b558154644 "2"^^ . _:b558154210 . _:b558151206 "3"^^ . _:b558154211 . _:b558154220 . _:b558155128 . _:b558154185 . _:b558154221 . _:b558154647 "2"^^ . _:b558154222 . _:b558151201 "3"^^ . _:b558154223 . _:b558154216 . _:b558154184 . _:b558154217 . _:b558154646 "2"^^ . _:b558154218 . _:b558151200 "3"^^ . _:b558154219 . _:b558154132 . _:b558154187 . _:b558154133 . _:b558154641 "2"^^ . _:b558151219 . . _:b558154134 . _:b558151203 "3"^^ . _:b558154135 . _:b558154128 . _:b558154186 . _:b558154129 . _:b558155499 . _:b558154640 "2"^^ . _:b558152180 . _:b558154130 . _:b558152040 . _:b558149487 . _:b558151202 "3"^^ . _:b558154131 . _:b558154140 . _:b558154197 . . _:b558154141 . _:b558154643 "2"^^ . . _:b558154142 . _:b558151213 "3"^^ . _:b558154143 . _:b558154136 . _:b558154196 . _:b558154137 . _:b558154642 "2"^^ . _:b558154138 . _:b558151283 . _:b558151212 "3"^^ . _:b558154139 . _:b558154116 . _:b558154199 . _:b558154117 . _:b558154653 "2"^^ . _:b558149681 . . _:b558149103 . _:b558154118 . _:b558151215 "3"^^ . _:b558154119 . _:b558154112 . _:b558154198 . _:b558154113 . _:b558154652 "2"^^ . _:b558154114 . _:b558151214 "3"^^ . . _:b558154115 . _:b558154124 . _:b558154193 . _:b558154125 . _:b558154655 "2"^^ . _:b558154126 . _:b558151209 "3"^^ . _:b558153938 . _:b558154127 . _:b558154120 . _:b558154192 . _:b558154121 . _:b558154654 "2"^^ . _:b558154122 . _:b558151208 "3"^^ . _:b558154123 . _:b558154164 . _:b558154195 . _:b558154165 . _:b558154649 "2"^^ . _:b558154166 . _:b558151211 "3"^^ . _:b558153569 . _:b558154167 . _:b558154160 . _:b558154194 . _:b558151508 . _:b558154161 . _:b558154648 "2"^^ . _:b558154162 . _:b558151210 "3"^^ . _:b558153078 . . _:b558154163 . _:b558154172 . _:b558154205 . _:b558154173 . _:b558154651 "2"^^ . _:b558154174 . _:b558151221 "3"^^ . _:b558153552 . _:b558154175 . _:b558151033 . _:b558155310 . _:b558154204 . _:b558154168 . _:b558154169 . _:b558156438 . _:b558154650 "2"^^ . . _:b558154170 . _:b558155547 . _:b558151220 "3"^^ . . _:b558154171 . _:b558154148 . _:b558154207 . _:b558154149 . _:b558154661 "2"^^ . _:b558154150 . _:b558154151 . _:b558151223 "3"^^ . _:b558154144 . _:b558154206 . _:b558154145 . _:b558154660 "2"^^ . _:b558154146 . _:b558151222 "3"^^ . _:b558152058 . _:b558154147 . _:b558154156 . _:b558154201 . _:b558154157 . _:b558154663 "2"^^ . _:b558151662 . _:b558154158 . _:b558151217 "3"^^ . _:b558155555 . . _:b558154159 . _:b558154152 . _:b558154200 . _:b558154153 . _:b558154662 "2"^^ . _:b558154154 . _:b558151216 "3"^^ . _:b558154155 . _:b558153812 . _:b558154203 . _:b558153813 . _:b558154657 "2"^^ . _:b558153814 . _:b558151219 "3"^^ . _:b558151473 . _:b558153815 . _:b558153808 . _:b558154202 . _:b558153809 . _:b558154656 "2"^^ . _:b558153810 . . _:b558151218 "3"^^ . _:b558153811 . _:b558153820 . _:b558154213 . _:b558153821 . _:b558154659 "2"^^ . _:b558152933 . _:b558153822 . _:b558154603 . _:b558149782 . . _:b558151229 "3"^^ . . _:b558153823 . _:b558153816 . _:b558154212 . . . _:b558154658 "2"^^ . _:b558153817 . . _:b558153818 . _:b558153819 . _:b558151228 "3"^^ . . . _:b558154215 . _:b558153796 . _:b558153797 . _:b558154669 "2"^^ . . _:b558153798 . _:b558149197 . _:b558153799 . _:b558151231 "3"^^ . . _:b558154214 . _:b558153792 . _:b558153793 . _:b558154668 "2"^^ . . _:b558153794 . . _:b558151230 "3"^^ . _:b558153795 . _:b558153804 . _:b558154209 . _:b558153805 . _:b558154671 "2"^^ . . . _:b558153806 . _:b558153807 . _:b558151225 "3"^^ . _:b558153800 . _:b558154208 . _:b558153801 . _:b558154670 "2"^^ . _:b558151200 . _:b558153802 . _:b558153803 . _:b558151224 "3"^^ . _:b558153844 . _:b558154211 . . _:b558153845 . _:b558154665 "2"^^ . _:b558153846 . _:b558153847 . _:b558151227 "3"^^ . _:b558153840 . _:b558154210 . . _:b558153841 . _:b558154664 "2"^^ . _:b558152335 . _:b558153842 . _:b558154545 . _:b558153445 . _:b558153843 . _:b558151226 "3"^^ . _:b558153852 . _:b558154221 . . _:b558148785 . _:b558154667 "2"^^ . _:b558153853 . _:b558153854 . _:b558154004 . _:b558153855 . _:b558151237 "3"^^ . _:b558153848 . _:b558154220 . _:b558153849 . _:b558156468 . _:b558155267 . _:b558154666 "2"^^ . _:b558153850 . . _:b558153851 . _:b558151236 "3"^^ . . _:b558154223 . _:b558153828 . _:b558153829 . _:b558154677 "2"^^ . _:b558153830 . . _:b558153831 . _:b558151239 "3"^^ . _:b558153824 . _:b558154222 . _:b558153825 . _:b558154676 "2"^^ . . _:b558153826 . _:b558153827 . _:b558151238 "3"^^ . _:b558153836 . _:b558154217 . _:b558153837 . _:b558154932 . _:b558154679 "2"^^ . _:b558153838 . _:b558153839 . _:b558151233 "3"^^ . _:b558153832 . _:b558154216 . _:b558153833 . _:b558154678 "2"^^ . _:b558153834 . _:b558153835 . _:b558154565 . _:b558151232 "3"^^ . _:b558153748 . _:b558154219 . . _:b558154673 "2"^^ . _:b558153749 . _:b558153750 . _:b558153751 . _:b558151852 . _:b558151235 "3"^^ . _:b558153744 . _:b558154218 . . . _:b558154672 "2"^^ . _:b558153745 . _:b558153746 . _:b558153326 . _:b558153747 . _:b558151234 "3"^^ . _:b558153756 . _:b558154229 . _:b558152091 . _:b558153757 . _:b558154675 "2"^^ . _:b558152442 . _:b558153758 . _:b558153759 . _:b558151245 "3"^^ . _:b558153752 . _:b558154228 . _:b558153753 . _:b558154674 "2"^^ . . _:b558153754 . _:b558153755 . _:b558151244 "3"^^ . . _:b558154231 . _:b558150147 . _:b558153732 . _:b558153733 . _:b558154685 "2"^^ . _:b558153734 . _:b558156328 . _:b558153735 . _:b558151247 "3"^^ . . _:b558153728 . _:b558154230 . _:b558153729 . _:b558154684 "2"^^ . _:b558153730 . _:b558153731 . _:b558151246 "3"^^ . . _:b558154225 . _:b558153740 . _:b558153741 . _:b558154687 "2"^^ . _:b558153742 . _:b558155136 . _:b558153743 . _:b558151241 "3"^^ . _:b558153736 . _:b558154224 . _:b558153737 . _:b558154686 "2"^^ . _:b558153738 . _:b558153739 . _:b558151240 "3"^^ . _:b558153780 . _:b558154227 . . _:b558153781 . _:b558154681 "2"^^ . _:b558153782 . _:b558153783 . _:b558151243 "3"^^ . _:b558153776 . _:b558154226 . _:b558149020 . _:b558153777 . _:b558154680 "2"^^ . _:b558153778 . . _:b558151242 "3"^^ . . _:b558153779 . . _:b558153788 . _:b558154237 . 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. _:b558153948 . _:b558153733 . _:b558153949 . _:b558154691 "2"^^ . _:b558153950 . _:b558153951 . _:b558151261 "3"^^ . . _:b558153944 . _:b558153732 . _:b558153945 . _:b558154690 "2"^^ . . _:b558153946 . _:b558153947 . _:b558151260 "3"^^ . _:b558153924 . _:b558153735 . . _:b558153925 . _:b558154701 "2"^^ . _:b558153926 . _:b558149829 . _:b558153927 . _:b558151263 "3"^^ . _:b558153920 . _:b558153734 . _:b558153921 . _:b558154700 "2"^^ . _:b558153922 . . _:b558151262 "3"^^ . _:b558153923 . _:b558153932 . _:b558153729 . _:b558153933 . _:b558154703 "2"^^ . _:b558153934 . _:b558153935 . _:b558151257 "3"^^ . _:b558153928 . _:b558156022 . _:b558154394 . _:b558153728 . _:b558148901 . _:b558153929 . _:b558154702 "2"^^ . _:b558153930 . _:b558153931 . _:b558151256 "3"^^ . _:b558153972 . _:b558153731 . _:b558153973 . _:b558154697 "2"^^ . _:b558153974 . _:b558153975 . _:b558151259 "3"^^ . _:b558153968 . _:b558153730 . _:b558153969 . _:b558154696 "2"^^ . _:b558153970 . _:b558153971 . _:b558151258 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mutations in PIK3CA and STK11, STK11 protein levels, and AMPK and AKT phosphorylation>>33<< led to the identification of three major mTOR patterns in lung adenocarcinoma:" . _:b558153971 . _:b558154805 . _:b558153913 "2"^^ . _:b558150633 . _:b558154806 . . _:b558151499 "3"^^ . _:b558154807 . . _:b558154800 . _:b558153970 . _:b558154801 . _:b558153912 "2"^^ . _:b558154802 . _:b558154803 . _:b558151498 "3"^^ . _:b558154812 . _:b558153981 . _:b558154813 . _:b558153915 "2"^^ . _:b558154814 . _:b558154815 . _:b558151509 "3"^^ . _:b558154808 . _:b558153980 . . _:b558154809 . _:b558153914 "2"^^ . _:b558154810 . _:b558154811 . _:b558152283 . _:b558151508 "3"^^ . _:b558154788 . _:b558153983 . _:b558154789 . _:b558153925 "2"^^ . _:b558153585 . _:b558154790 . _:b558154791 . _:b558151511 "3"^^ . _:b558154784 . _:b558153982 . _:b558154785 . _:b558153924 "2"^^ . _:b558154786 . _:b558154787 . _:b558151510 "3"^^ . _:b558154796 . _:b558153977 . _:b558154797 . _:b558153927 "2"^^ . _:b558154798 . . 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. . _:b558151539 "3"^^ . _:b558153952 "2"^^ . _:b558151538 "3"^^ . . _:b558153955 "2"^^ . _:b558151549 "3"^^ . _:b558153954 "2"^^ . _:b558153451 . _:b558150402 . _:b558156231 . _:b558151548 "3"^^ . . _:b558153965 "2"^^ . _:b558152896 . _:b558151551 "3"^^ . _:b558149786 . . _:b558153964 "2"^^ . _:b558151550 "3"^^ . _:b558150244 . _:b558156372 . _:b558153967 "2"^^ . . _:b558151545 "3"^^ . _:b558149054 . _:b558153966 "2"^^ . _:b558151544 "3"^^ . . _:b558153961 "2"^^ . . _:b558151547 "3"^^ . . _:b558153960 "2"^^ . _:b558154847 . _:b558149731 . _:b558151546 "3"^^ . . _:b558153963 "2"^^ . _:b558151557 "3"^^ . _:b558153134 . _:b558153962 "2"^^ . _:b558151556 "3"^^ . _:b558149066 . _:b558153973 "2"^^ . _:b558151559 "3"^^ . _:b558153972 "2"^^ . _:b558151558 "3"^^ . _:b558153975 "2"^^ . _:b558151553 "3"^^ . _:b558153974 "2"^^ . . _:b558151552 "3"^^ . _:b558148707 . _:b558153969 "2"^^ . . _:b558153496 . _:b558151555 "3"^^ . . . _:b558153968 "2"^^ . _:b558151554 "3"^^ . . . _:b558153971 "2"^^ . 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these samples, a 5\u2032 or 3\u2032 splice site mutation or deletion was identified>>27<<. MET exon 14 skipping was also found in the setting of a MET Y1003* stop codon mutation (Fig. 2b, Supplementary Fig. 8a). The codon affected by the Y1003* mutation is predicted to disrupt multiple splicing enhancer sequences, but the" . _:b558151636 "3"^^ . _:b558151844 . _:b558154053 "2"^^ . . _:b558151639 "3"^^ . . _:b558154052 "2"^^ . _:b558151638 "3"^^ . . _:b558154055 "2"^^ . . _:b558151633 "3"^^ . _:b558150348 . _:b558154054 "2"^^ . _:b558151632 "3"^^ . _:b558154049 "2"^^ . . _:b558151635 "3"^^ . _:b33181493 . _:b558154048 "2"^^ . . _:b558152278 . _:b558151634 "3"^^ . _:b558154541 . _:b558154051 "2"^^ . _:b558151645 "3"^^ . _:b558154050 "2"^^ . . _:b558151644 "3"^^ . . _:b558154061 "2"^^ . . . _:b558151647 "3"^^ . _:b558154060 "2"^^ . . _:b558151408 . _:b558151646 "3"^^ . _:b558154063 "2"^^ . . _:b558151641 "3"^^ . . _:b558154062 "2"^^ . . _:b558155798 . _:b558151640 "3"^^ . . _:b558154057 "2"^^ . _:b558149453 . _:b558151643 "3"^^ . _:b558156207 . _:b558154056 "2"^^ . _:b558151642 "3"^^ . . _:b558150123 . _:b558154059 "2"^^ . . . _:b558151653 "3"^^ . _:b558154058 "2"^^ . _:b558151652 "3"^^ . 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. _:b558149358 . _:b558151160 "3"^^ . _:b33181482 "Significantly mutated genes were identified by comparing them with expectation models based on the exact measured rates of specific sequence lesions>>42<<. GISTIC analysis of the circular-binary-segmented Affymetrix SNP 6.0 copy number data was used to identify recurrent amplification and deletion peaks31. Consensus clustering approaches were used to analyse mRNA, miRNA and methylation" . . _:b558148720 . _:b558151404 . . _:b558149774 . _:b558151163 "3"^^ . _:b558151162 "3"^^ . . _:b558150149 "4"^^ . _:b558150148 "4"^^ . _:b558155808 . _:b558150151 "4"^^ . . _:b558150150 "4"^^ . . _:b558150145 "4"^^ . . . . _:b558150144 "4"^^ . . _:b558150147 "4"^^ . _:b558150146 "4"^^ . _:b558155404 . _:b558150157 "4"^^ . _:b558152627 . _:b558150156 "4"^^ . . _:b558152018 . _:b558149005 . _:b558154834 . _:b558150159 "4"^^ . _:b558156092 . _:b558150960 . _:b558150158 "4"^^ . _:b558150153 "4"^^ . . _:b558150152 "4"^^ . _:b558153325 . _:b558150155 "4"^^ . . _:b558150154 "4"^^ . _:b558151763 . . _:b558150165 "4"^^ . _:b558150164 "4"^^ . . _:b558151518 . _:b558150167 "4"^^ . . _:b558154761 . _:b558150166 "4"^^ . . _:b558154490 . _:b558150161 "4"^^ . _:b558150160 "4"^^ . . _:b558150163 "4"^^ . _:b558153145 . _:b558150162 "4"^^ . _:b558150173 "4"^^ . . _:b558150172 "4"^^ . . . _:b558150175 "4"^^ . _:b558150174 "4"^^ . _:b558153810 . _:b558150169 "4"^^ . _:b558150168 "4"^^ . . _:b558150171 "4"^^ . . _:b558151079 . . _:b558150170 "4"^^ . _:b558149367 . _:b558150181 "4"^^ . _:b558153348 . _:b558151303 . _:b558155287 . _:b558150180 "4"^^ . _:b558150183 "4"^^ . . . _:b558150182 "4"^^ . . _:b558150177 "4"^^ . . _:b558150176 "4"^^ . . _:b558150179 "4"^^ . _:b558151152 . _:b558150178 "4"^^ . _:b558150807 . _:b558150189 "4"^^ . . . _:b558150188 "4"^^ . . _:b558151660 . _:b558150191 "4"^^ . _:b558153262 . . _:b558149476 . _:b558150190 "4"^^ . _:b558150185 "4"^^ . . _:b558150184 "4"^^ . _:b558153807 . _:b558152355 . _:b558150187 "4"^^ . _:b558150090 . _:b558154374 . _:b558150186 "4"^^ . _:b558151092 . _:b558150197 "4"^^ . . _:b558150196 "4"^^ . _:b558150199 "4"^^ . . _:b558150198 "4"^^ . _:b558150193 "4"^^ . _:b558150192 "4"^^ . _:b558150840 . _:b558156193 . _:b558154031 . _:b558150195 "4"^^ . _:b558150194 "4"^^ . _:b558150205 "4"^^ . _:b558155193 . _:b558150204 "4"^^ . . _:b558150207 "4"^^ . _:b558156298 . . _:b558150206 "4"^^ . _:b558151810 . . . _:b558150201 "4"^^ . . _:b558150200 "4"^^ . . _:b558149802 . _:b558149176 . _:b558150203 "4"^^ . _:b558150202 "4"^^ . _:b558155299 . _:b558150213 "4"^^ . _:b558154513 . _:b558150212 "4"^^ . _:b558155727 . . . _:b558150215 "4"^^ . _:b558149756 . _:b558148420 . _:b558148381 . _:b558150214 "4"^^ . . . _:b558150209 "4"^^ . _:b558150208 "4"^^ . _:b558153169 . . . _:b558150211 "4"^^ . _:b558152635 . _:b558149140 . _:b558150210 "4"^^ . . . _:b558149695 . _:b558150221 "4"^^ . _:b558156079 . _:b558150220 "4"^^ . _:b558156080 . . . . _:b558150223 "4"^^ . _:b558150222 "4"^^ . _:b558155571 . _:b558150217 "4"^^ . . . . _:b558150216 "4"^^ . . . _:b558152206 . . _:b558150219 "4"^^ . _:b558150218 "4"^^ . _:b558150229 "4"^^ . _:b558150228 "4"^^ . . . _:b558150231 "4"^^ . . . . . _:b558151493 . _:b558152749 . _:b558150230 "4"^^ . . _:b558150225 "4"^^ . _:b558154718 . _:b558150224 "4"^^ . _:b558148794 . _:b558151880 . _:b558150227 "4"^^ . . . _:b558156255 . _:b558150226 "4"^^ . _:b558151249 . _:b558150237 "4"^^ . _:b558150236 "4"^^ . _:b558153729 . . _:b558150239 "4"^^ . _:b558150238 "4"^^ . _:b558151938 . . _:b558150233 "4"^^ . . _:b558149210 . . _:b558150232 "4"^^ . _:b558155250 . . _:b558154383 . . _:b558150235 "4"^^ . _:b558152134 . _:b558152652 . _:b558150234 "4"^^ . . . . _:b558150245 "4"^^ . _:b558150244 "4"^^ . _:b558150425 . _:b558150247 "4"^^ . _:b33181487 "DNA, RNA and protein were extracted from specimens and quality-control assessments were performed as described previously>>15<<. Supplementary Table 3 summarizes molecular estimates of tumour cellularity16." . . _:b558152661 . _:b558150246 "4"^^ . . _:b558150262 . _:b558149601 . _:b558150241 "4"^^ . . _:b558150240 "4"^^ . . _:b558154704 . _:b558150243 "4"^^ . _:b558153131 . _:b558152009 . _:b558150242 "4"^^ . _:b558154441 . . . . _:b558150253 "4"^^ . _:b558152305 . _:b558150252 "4"^^ . _:b558150255 "4"^^ . _:b558156005 . _:b558150254 "4"^^ . _:b558150240 . _:b558150249 "4"^^ . _:b558149082 . . _:b558150248 "4"^^ . _:b558150251 "4"^^ . . _:b558150250 "4"^^ . _:b558155134 . _:b558149560 . _:b558150261 "4"^^ . . _:b558152616 . . . _:b558148859 . _:b558150260 "4"^^ . _:b558150263 "4"^^ . _:b558152477 . _:b558150262 "4"^^ . _:b558150257 "4"^^ . . _:b558150256 "4"^^ . _:b558150259 "4"^^ . _:b558148947 . _:b558150258 "4"^^ . . _:b558150269 "4"^^ . _:b558150580 . _:b558150366 . _:b558150268 "4"^^ . . _:b558156027 . _:b558148676 . . _:b558150271 "4"^^ . _:b558148517 . _:b558151659 . . _:b558149078 . _:b558150270 "4"^^ . . . _:b558155248 . _:b558150265 "4"^^ . . . . _:b558150264 "4"^^ . _:b558148482 . _:b558153299 . _:b558149710 . . _:b558150267 "4"^^ . _:b558155349 . _:b558150266 "4"^^ . _:b558150277 "4"^^ . . _:b558150276 "4"^^ . _:b558154659 . _:b558150279 "4"^^ . _:b558155258 . _:b558148307 . _:b558150278 "4"^^ . . _:b558155655 . _:b558150273 "4"^^ . _:b558154626 . _:b558154369 . . . _:b558150272 "4"^^ . _:b558150728 . _:b558154159 . _:b558150275 "4"^^ . _:b558148802 . _:b558150274 "4"^^ . . _:b558150285 "4"^^ . _:b558148320 . _:b558150284 "4"^^ . . . _:b558150287 "4"^^ . _:b558151906 . . _:b558149417 . _:b558154449 . _:b558150286 "4"^^ . _:b558155124 . _:b558156204 . _:b558150281 "4"^^ . _:b558150280 "4"^^ . . . _:b558150283 "4"^^ . _:b558150282 "4"^^ . _:b558150293 "4"^^ . _:b558150292 "4"^^ . . _:b558148766 . _:b558150295 "4"^^ . _:b558149362 . . _:b558150294 "4"^^ . . _:b558149674 . _:b558150289 "4"^^ . _:b558150288 "4"^^ . _:b558150291 "4"^^ . _:b558150290 "4"^^ . _:b558151965 . . . _:b558150301 "4"^^ . . _:b558150883 . _:b558150300 "4"^^ . _:b558150303 "4"^^ . _:b558150302 "4"^^ . _:b558150297 "4"^^ . . _:b558151981 . . _:b558155262 . _:b558150296 "4"^^ . . . _:b558148627 . _:b558150299 "4"^^ . . . _:b558150298 "4"^^ . _:b558150309 "4"^^ . _:b558150308 "4"^^ . _:b558149750 . _:b558155630 . . _:b558150311 "4"^^ . _:b558149001 . . _:b558148400 . _:b558150310 "4"^^ . _:b558155411 . _:b558154016 . _:b558150305 "4"^^ . _:b558151912 . . . _:b558150304 "4"^^ . _:b558150307 "4"^^ . . . . . _:b558150306 "4"^^ . . . _:b558150317 "4"^^ . _:b558150316 "4"^^ . _:b558153910 . _:b558150319 "4"^^ . . _:b558153939 . _:b558150318 "4"^^ . _:b558152142 . _:b558154156 . _:b558150313 "4"^^ . . _:b558150312 "4"^^ . _:b558151753 . . _:b558150315 "4"^^ . . _:b558154889 . . _:b558150314 "4"^^ . _:b558150325 "4"^^ . . _:b558150324 "4"^^ . _:b558156110 . _:b558152084 . _:b558150327 "4"^^ . . . . _:b558150326 "4"^^ . _:b558154610 . _:b558150321 "4"^^ . . _:b558150320 "4"^^ . _:b558150323 "4"^^ . _:b558150322 "4"^^ . _:b558149152 . . _:b558150333 "4"^^ . . . _:b558150332 "4"^^ . . _:b558150335 "4"^^ . _:b558149871 . . _:b558150334 "4"^^ . . . _:b558150329 "4"^^ . _:b558156430 . _:b558155865 . _:b558150328 "4"^^ . . . _:b558148369 . _:b558150331 "4"^^ . _:b558150330 "4"^^ . _:b558150341 "4"^^ . _:b558149219 . . _:b558150340 "4"^^ . _:b558149730 . _:b558150343 "4"^^ . _:b558155172 . . . _:b558150342 "4"^^ . _:b558153146 . _:b558150337 "4"^^ . _:b558150336 "4"^^ . . _:b558151403 . _:b558149768 . _:b558150339 "4"^^ . _:b558151843 . _:b558148857 . _:b558150338 "4"^^ . . _:b558148709 . _:b558149046 . _:b558151994 . _:b558150349 "4"^^ . . _:b558154047 . _:b558153740 . _:b558150348 "4"^^ . _:b558152803 . _:b558148765 . _:b558148831 . _:b558150014 . . _:b558150351 "4"^^ . _:b558152110 . . _:b558150350 "4"^^ . . . _:b558156096 . _:b558153399 . . _:b558150345 "4"^^ . . _:b558150344 "4"^^ . . _:b558150347 "4"^^ . _:b558150346 "4"^^ . . . _:b558150357 "4"^^ . _:b558150933 . _:b558150356 "4"^^ . _:b558150359 "4"^^ . _:b558149824 . _:b558153273 . _:b558150358 "4"^^ . _:b558150353 "4"^^ . . . _:b558150352 "4"^^ . . _:b558150355 "4"^^ . . _:b558150354 "4"^^ . _:b558150703 . _:b558150365 "4"^^ . _:b558154249 . _:b558154418 . _:b558150011 . _:b558150364 "4"^^ . _:b558151180 . _:b558150367 "4"^^ . _:b558150366 "4"^^ . . _:b558153168 . _:b558150361 "4"^^ . _:b558150360 "4"^^ . _:b558150773 . . _:b558150363 "4"^^ . _:b558149592 . . _:b558150362 "4"^^ . . _:b558150373 "4"^^ . _:b558153234