. _:b595519163 . _:b595520188 . _:b595520223 . _:b595518427 . . . . . _:b595518279 . _:b595519208 . _:b595519149 . . _:b595518452 . _:b47353791 . _:b595520051 . _:b595519878 . _:b595518619 . . . . _:b595518916 . _:b595520232 . . _:b595518918 . . _:b595518205 . . . _:b595518384 . . . _:b595519260 . . _:b595518026 . . . . _:b595519206 . _:b595520073 . _:b595520079 . . . _:b595519758 . . . _:b595518260 . _:b595518803 . . _:b595519652 . . _:b595519802 . . . . _:b595519648 . _:b595519729 . _:b595519431 . _:b595520380 . . . . _:b595519383 . . _:b595519296 . _:b595520068 . . . . _:b47353814 "The following CRISPR small guide RNAs were cloned into the LentiCRISPR vector obtained from the Zhang lab>>43<<: GFP: 5\u2032-GAG CTG GAC GGC GAC GTA AA -3\u2032, Insulator: 5\u2032-GCC ACA GAT AAT GCA GCT AGA -3\u2032." . . _:b595519223 . _:b595518007 . . _:b595520317 . _:b595520216 . . _:b595519284 . _:b595518782 . . _:b595519113 . . _:b595519791 . _:b595518849 . . _:b595520434 . _:b595520306 . _:b595520399 . _:b595518675 . . . . _:b595519151 . . . . . _:b595519250 . . _:b595519243 . . . . _:b595518289 . . _:b595518315 . . . _:b595519643 . _:b595519684 . . _:b595520272 . _:b595518597 . _:b595518852 . _:b595520009 . . . . _:b595519778 . . _:b595520265 . _:b595518192 . _:b595518365 . _:b595520377 . _:b595519757 . _:b595519937 . _:b47353799 . _:b595518032 . . _:b595518319 . . . _:b595520129 . _:b595518746 . _:b595520504 . . . . _:b595520256 . . . _:b595519307 . _:b595518595 . . . . _:b595520520 . _:b595518521 . _:b595519634 . . . . _:b595519354 . _:b595520107 . _:b595519422 . . _:b595519539 . _:b595519306 . . _:b595519034 . . . . _:b595519280 . . . _:b595519027 . _:b595518661 . . _:b595519613 . _:b595518650 . . . _:b595520238 . . _:b595518090 . . . _:b595520173 . _:b595519465 . . _:b595520349 . . _:b595520509 . _:b595518703 . . . . _:b595519386 . . _:b595518473 . _:b595520092 . _:b595518620 . . _:b595520246 . . _:b595519147 . . . _:b595518892 . _:b595519304 . _:b595518833 . . . _:b595520308 . . _:b595518553 . . . _:b595519928 . _:b595518511 . . . _:b595519509 . _:b595520006 . _:b595520055 . _:b595518375 . . . . _:b595518510 . _:b595518028 . _:b595519447 . _:b595520217 . . . _:b595520048 . . _:b595520302 . _:b595519252 . _:b595519614 . . . _:b595518290 . . . _:b595519132 . . _:b595519889 . _:b595519349 . _:b595518283 . . . . _:b595519174 . . _:b595518436 . . _:b595519254 . _:b595519965 . _:b595520448 . _:b595518348 . . . _:b595519874 . _:b595518959 . _:b595520144 . _:b595518658 . _:b595519868 . . _:b595519994 . . . . . _:b595518379 . . . _:b595518067 . _:b595519264 . _:b595520413 . . _:b595519468 . _:b595518941 . . . . . . _:b595519656 . . _:b595518533 . . . . _:b595520393 . _:b595518297 . _:b595518316 . _:b595519081 . . . . _:b595519625 . . _:b595520283 . . _:b595518588 . . _:b595518038 . . _:b595519035 . _:b595520263 . _:b595518092 . _:b595518402 . _:b595518670 . . . . _:b595518774 . . _:b595518443 . . _:b47353807 . _:b595520293 . _:b595518579 . _:b595520098 . _:b47353802 "RNA-seq data and copy number profiles for lower grade gliomas were downloaded from TCGA23,>>24<<. Contact domains of IMR90, GM12878, K562 and NHEK cells were obtained from published HiC data15. Genes were assigned to the inner most domain their transcription start site fell within. Gene pairs were considered to be in the same domain" . _:b595519302 . _:b595519792 . _:b595518985 . . . . . _:b595519173 . . _:b595518822 . . _:b595520505 . _:b595518453 . _:b595519921 . . _:b595518409 . . . _:b595519162 . . _:b595520198 . . . _:b595519774 . _:b595518415 . _:b595518220 . _:b595518926 . . . . . . _:b595519332 . . . _:b595519721 . . . _:b595519524 . _:b595518178 . . . _:b595519261 . _:b595518789 . _:b595519775 . . _:b595518716 . . . _:b595518312 . _:b595520492 . _:b595518431 . . _:b595519479 . . _:b595519689 . . _:b595518091 . _:b595519248 . . . . . _:b595520408 . _:b595518006 . _:b595518836 . _:b595518754 . _:b595520112 . . _:b595519846 . _:b595519087 . . _:b595518154 . . _:b595518314 . _:b595519384 . . _:b595520366 . . _:b595518953 . . . . . . _:b595518759 . _:b595518435 . _:b595518747 . _:b595519527 . _:b595519448 . . . . _:b595518060 . . _:b595519341 . . _:b595518721 . _:b595520157 . _:b595518242 . . _:b595519136 . _:b595519675 . . _:b595517999 . _:b595518576 . _:b595518622 . . . _:b595518515 . _:b595518169 . _:b595520476 . _:b595518966 . . _:b595518142 . . . _:b595518025 . . _:b595520342 . . _:b595518659 . . . _:b595518683 . . . . _:b595519205 . . _:b595519742 . _:b595518479 . . _:b595520202 . . . . . _:b595520314 . . _:b595518036 . . . _:b595518468 . _:b595519558 . . _:b595519727 . _:b595518536 . . _:b595520529 . . . . . _:b595518423 . _:b595520056 . . _:b595519591 . _:b595518064 . _:b595518633 . . . _:b595520121 . . _:b47353805 "In addition to PDGFRA, top ranking genes include CHD4 (p<10\u221232), a driver of glioblastoma tumor initiation>>38<<, L1CAM (p<10\u22128), a regulator of the glioma stem cells and tumor growth39, and other candidate regulators (Supplemental Table 1)." . _:b595518835 . . _:b595520489 . _:b595520225 . . _:b595519404 . . _:b595520315 . _:b595518962 . . _:b595519337 . . . _:b595518552 . . . . . _:b595519316 . . . _:b595520354 . . _:b595518621 . . . _:b595518403 . _:b595518100 . . . _:b595519490 . _:b595519122 . _:b595519424 . . . . . _:b595519138 . . . _:b595519225 . _:b595518148 . _:b595518567 . _:b595518065 . _:b595518354 . _:b595520007 . . . _:b595518848 . . _:b595518664 . . _:b595518647 . . _:b595518159 . _:b595519514 . _:b595517994 . _:b595519687 . _:b595518213 . _:b595520169 . _:b595518690 . _:b595519478 . . _:b595518107 . . _:b595518011 . . . . _:b595520031 . _:b595519348 . . . _:b595518420 . . . . _:b595519220 . _:b595520499 . _:b595519366 . _:b595520062 . . . _:b595519364 . _:b595518623 . . _:b595518688 . . _:b595518240 . . . _:b595518165 . _:b595519453 . . . . _:b595518753 . . . _:b595519896 . . _:b595518362 . _:b595519476 . . . _:b595518780 . _:b595519624 . . _:b595520481 . _:b595519655 . . . _:b595518134 . . . . . _:b595519325 . _:b595519668 . . _:b595518269 . _:b595520389 . _:b595518499 . . . . _:b595518261 . _:b595519960 . _:b595518177 . . _:b595519842 . . . . _:b595518247 . . . . . _:b595518305 . . _:b47353795 "BT142 gliomasphere line (IDH1 mutant)>>35<< was obtained from ATCC, and cultured as described above except 25% conditioned media was carried over each passage." . . . . _:b595519948 . _:b595518676 . . _:b595519440 . _:b595519532 . . . . _:b595519566 . _:b595520427 . . _:b595518185 . . . . . . . . _:b595518807 . _:b595520433 . . _:b595518586 . . . . . . _:b595519278 . . _:b595518657 . _:b595518284 . . _:b595518369 . _:b595518528 . _:b595518933 . . _:b595520154 . _:b595518537 . . . . _:b595520134 . _:b595519062 . . . . _:b595519111 . . . _:b595518042 . . . . _:b595519237 . _:b595519236 . _:b595520459 . _:b595519239 . _:b595519238 . _:b595518304 . _:b595519233 . . _:b595519232 . _:b595519657 . _:b595519235 . _:b595520085 . _:b595519234 . _:b595519245 . _:b595519244 . _:b595519247 . _:b595519600 . _:b595519246 . _:b595520294 . _:b595519241 . _:b595519240 . _:b595519243 . . . . _:b595519242 . . _:b595519253 . . . _:b595519252 . _:b595519191 . _:b595519255 . _:b595519394 . _:b595519254 . _:b595519249 . _:b595518408 . _:b595519248 . _:b595518345 . _:b595519251 . . _:b595519250 . _:b595519261 . . _:b595519260 . _:b595518686 . _:b595519263 . _:b595519262 . _:b595519257 . _:b595519256 . _:b595519061 . _:b595518193 . . _:b595519259 . _:b595518114 . _:b595518915 . _:b595519258 . _:b595520468 . _:b595519269 . . _:b595519268 . . . _:b595519271 . . _:b595519270 . . _:b595519265 . . _:b595519264 . _:b595518309 . . _:b595519267 . . _:b595519266 . _:b595518606 . _:b595519277 . _:b595519276 . _:b595519279 . _:b595519278 . . . _:b595519273 . _:b595519272 . _:b595519275 . _:b595519274 . _:b595519159 . _:b595518105 . _:b595519285 . . _:b595519036 . _:b595519284 . _:b595519287 . _:b595519236 . _:b595519286 . . _:b595520108 . _:b595519281 . _:b595518412 . _:b595519280 . . _:b595519283 . _:b595520042 . _:b595519129 . _:b595519282 . . _:b595519293 . _:b595519292 . _:b595519295 . . . . _:b595519294 . _:b595519535 . . _:b595519289 . _:b595519288 . _:b595519291 . _:b595519469 . . _:b595519290 . _:b595519301 . . _:b595519300 . _:b595518475 . _:b595519633 . _:b595519303 . . _:b595519302 . _:b595519297 . _:b595519864 . _:b595519296 . _:b595518391 . . _:b595519299 . _:b595518979 . . _:b595519298 . . _:b47353801 . . _:b595519309 . _:b595519308 . . _:b595518557 . _:b595519311 . _:b595518578 . _:b595519702 . _:b595519310 . _:b595520324 . . _:b595519305 . _:b595518487 . _:b595519304 . _:b595519307 . _:b595519306 . . . _:b595519317 . _:b595519812 . _:b595519316 . . _:b595519249 . _:b595519319 . . _:b595519318 . _:b595518594 . . _:b595519313 . . _:b595519312 . _:b595518935 . . _:b595519315 . _:b595519031 . _:b595519515 . . _:b595519314 . _:b595519325 . . . _:b595519324 . . _:b595520420 . . _:b595519327 . . _:b595519326 . _:b595520490 . _:b595519321 . _:b595519371 . _:b595519320 . . _:b595518292 . _:b595519323 . _:b595519847 . . _:b595519322 . . _:b595519333 . . _:b595519332 . _:b595519335 . . _:b595519334 . _:b595519329 . _:b595520267 . _:b595520029 . _:b595519328 . . . _:b595519331 . . _:b595519330 . . _:b595518464 . _:b595519341 . _:b595519340 . _:b595519343 . . _:b595519342 . _:b47353806 . _:b595519337 . . _:b595519336 . _:b595519339 . _:b595519338 . _:b595519349 . _:b595518350 . _:b595519348 . _:b595519351 . _:b595519350 . _:b595519345 . . _:b595519344 . _:b595518878 . _:b595519324 . . _:b595519347 . _:b595519735 . _:b595519346 . _:b595520032 . _:b595519357 . _:b595519356 . . _:b595519152 . _:b595519359 . _:b595519358 . _:b595519353 . _:b595519352 . _:b595519355 . _:b595519354 . _:b595519365 . _:b595519364 . . _:b595519367 . . _:b595519366 . . _:b595518004 . _:b595519361 . _:b595519360 . _:b595519363 . . _:b595520486 . _:b595519362 . . _:b595519373 . . _:b595519372 . . _:b595519375 . _:b595519374 . . _:b595519369 . _:b595520454 . _:b595519368 . _:b595520045 . _:b595519371 . . _:b595519370 . _:b595519381 . _:b595519380 . . _:b47353798 . _:b595519383 . . _:b595519382 . _:b595519098 . _:b595519377 . _:b595519046 . _:b595519376 . . _:b595519379 . _:b595518433 . _:b595519378 . _:b595519389 . . _:b595519388 . _:b595519391 . . . _:b595519390 . . _:b595520030 . _:b595519385 . . _:b595518762 . _:b595519384 . _:b595518378 . _:b595519387 . _:b595519386 . _:b595518864 . . _:b595519397 . _:b595519396 . _:b595519569 . _:b595519399 . _:b595519398 . _:b47353799 "Methylation levels were quantified over these same regions for 3 IDH mutant and 3 IDH wildtype tumors, using TCGA data generated by whole genome bisulfite sequencing>>10<<. Briefly, methylation levels (%) based on proportion of reads with protected CpG were averaged over all CpG dinucleotides in these regions, treating each tumor separately." . _:b47353792 "Gliomaspheres were maintained in culture as described>>32<<,33. Briefly, neurosphere cultures contain Neurobasal media supplemented with 20 ng/mL recombinant EGF (R and D Systems), 20ng/mL FGF2 (R and D Systems), 1X B27 supplement (Invitrogen), 0.5X N2 supplement (Invitrogen), 3mM L-glutamine, and" . _:b595519393 . _:b595519392 . _:b595518372 . _:b595519395 . _:b595518326 . _:b595519394 . _:b595518399 . _:b595519405 . _:b595519404 . . _:b595520069 . . _:b595519681 . _:b595519202 . _:b595519407 . _:b595519406 . . . _:b595519401 . _:b595520319 . _:b595519400 . _:b595519403 . _:b595519402 . . _:b595519413 . . . _:b595519412 . _:b595519415 . _:b595519414 . _:b595519409 . . _:b595519408 . _:b595520249 . _:b595519411 . _:b595519410 . _:b595519421 . . _:b595519420 . _:b595519086 . _:b595519423 . _:b595518440 . _:b595519422 . _:b595519417 . . _:b595519416 . _:b595519419 . . . . _:b595519418 . _:b595519491 . _:b595518180 . _:b595519429 . . _:b595518861 . _:b595519428 . _:b595519431 . _:b595519916 . . . _:b595519430 . . _:b595519425 . _:b595520145 . _:b595519424 . . _:b595519427 . . _:b595519426 . . _:b595519437 . . _:b595519436 . . _:b595520428 . _:b595519439 . _:b595519432 . . _:b595519438 . _:b595519433 . _:b595518660 . _:b595519432 . _:b595519435 . . . _:b595519434 . _:b595520103 . _:b595518986 . _:b595519445 . _:b595520517 . . _:b595519444 . _:b595519447 . . _:b595518607 . _:b595519446 . _:b595519441 . _:b595520474 . _:b595519265 . _:b595519440 . _:b595519443 . . _:b595519442 . _:b595519453 . . _:b595519452 . . _:b595519455 . _:b595519454 . . _:b595519449 . _:b595519807 . . _:b595519448 . _:b595519451 . . _:b595519450 . _:b595519998 . _:b595520398 . _:b595519461 . _:b595519460 . _:b595520391 . _:b595518960 . _:b595519463 . . _:b595520477 . _:b595519462 . . _:b595519457 . . . _:b595519456 . . . _:b595518162 . . _:b595519459 . . _:b595519458 . _:b595519863 . _:b595519469 . . _:b595519468 . . _:b595519471 . _:b595518602 . _:b595519109 . . _:b595519498 . _:b595519470 . _:b595519712 . _:b595519465 . _:b595519464 . _:b595519467 . . _:b595519466 . _:b595519477 . . _:b595519848 . _:b595519772 . _:b595519476 . _:b595519479 . _:b595518981 "3"^^ . _:b595519478 . _:b595518980 "3"^^ . . _:b595519473 . _:b595518983 "3"^^ . . _:b595519472 . _:b595518982 "3"^^ . _:b595519475 . _:b595518977 "3"^^ . _:b595519474 . _:b595518976 "3"^^ . . _:b595519017 . _:b595518979 "3"^^ . _:b595519485 . . _:b595519063 . _:b595519484 . _:b595520368 . _:b595518978 "3"^^ . _:b595519487 . _:b595518989 "3"^^ . _:b595519486 . . _:b595518988 "3"^^ . _:b595519685 . _:b595519481 . _:b595518991 "3"^^ . _:b595519480 . _:b595518990 "3"^^ . _:b595519483 . _:b595518985 "3"^^ . _:b595519482 . _:b595518984 "3"^^ . _:b595519106 . _:b595520372 . . _:b595518981 . _:b595518987 "3"^^ . _:b595518980 . _:b595518986 "3"^^ . . _:b595518983 . _:b595518997 "3"^^ . _:b595518982 . _:b595518996 "3"^^ . . _:b595518398 . _:b595518977 . _:b595518999 "3"^^ . _:b595518976 . _:b595518998 "3"^^ . . _:b595518979 . _:b595518993 "3"^^ . . . _:b595518978 . _:b595518992 "3"^^ . 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_:b595520358 . _:b595519019 "3"^^ . . _:b595519012 . _:b595519018 "3"^^ . _:b595519015 . _:b595519029 "3"^^ . _:b595519470 . . _:b595519014 . _:b595519028 "3"^^ . _:b595519009 . _:b595519031 "3"^^ . _:b595519097 . _:b595519008 . _:b595519030 "3"^^ . _:b595519011 . _:b595519025 "3"^^ . . _:b595519542 . _:b595519076 . _:b595519010 . _:b595519056 . _:b595519024 "3"^^ . _:b595518749 . _:b595519021 . _:b595519027 "3"^^ . _:b595519020 . _:b595519026 "3"^^ . _:b595519023 . _:b595519037 "3"^^ . . . _:b595519022 . . _:b595519036 "3"^^ . _:b595519017 . _:b595519039 "3"^^ . . _:b595519016 . _:b595519222 . _:b595519038 "3"^^ . . _:b595519019 . _:b595519033 "3"^^ . . . . _:b595519018 . _:b595519032 "3"^^ . . _:b595520478 . _:b595519929 . _:b595517990 . _:b595519029 . _:b595519035 "3"^^ . . _:b595520503 . _:b595519028 . _:b595519034 "3"^^ . _:b595519631 . . _:b595519031 . _:b595519045 "3"^^ . _:b595520120 . . _:b595519030 . _:b595519044 "3"^^ . _:b595519025 . _:b595519047 "3"^^ . _:b595519420 . 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"2"^^ . _:b595518428 . . _:b595518721 . . _:b595520039 . _:b595519254 "2"^^ . . _:b595518720 . . _:b595519249 "2"^^ . _:b595518723 . _:b595519343 . _:b595519248 "2"^^ . _:b595518722 . . _:b595519251 "2"^^ . _:b595518733 . . _:b595519250 "2"^^ . _:b595518732 . _:b595519261 "2"^^ . _:b595518735 . . _:b595519260 "2"^^ . _:b595518734 . _:b595520299 . _:b595519263 "2"^^ . _:b595518729 . _:b595519226 . _:b595519428 . _:b595519262 "2"^^ . _:b595518728 . _:b595519257 "2"^^ . _:b595518731 . . _:b595519256 "2"^^ . _:b595518730 . _:b595518020 . _:b595519259 "2"^^ . _:b595518234 . _:b595518741 . _:b595519258 "2"^^ . _:b595518740 . _:b595519057 . _:b595519269 "2"^^ . _:b595518743 . _:b595519268 "2"^^ . _:b595518742 . . _:b595519271 "2"^^ . _:b595518737 . . . _:b595519270 "2"^^ . . _:b595518736 . _:b595519265 "2"^^ . . _:b595518739 . . _:b595520403 . _:b595519264 "2"^^ . _:b595518738 . _:b595519267 "2"^^ . . _:b595518749 . _:b595519266 "2"^^ . _:b595518748 . _:b595519277 "2"^^ . _:b595518751 . _:b595519276 "2"^^ . _:b595518750 . _:b595519279 "2"^^ . _:b595518745 . _:b595520214 . . _:b595519278 "2"^^ . _:b595518744 . _:b595519273 "2"^^ . _:b595518747 . _:b595519272 "2"^^ . _:b595518746 . . _:b595519275 "2"^^ . _:b595518757 . . "PMC0" . _:b595519274 "2"^^ . _:b595518785 . . _:b595518756 . _:b595519285 "2"^^ . _:b595517992 . _:b595518759 . _:b595519284 "2"^^ . _:b595518758 . . _:b595519287 "2"^^ . _:b595518753 . _:b595519286 "2"^^ . _:b595518752 . _:b595519281 "2"^^ . _:b47353808 "For the correlation of FIP1L1 and PDGFRA expression, RNAseq data from the TCGA Lower Grade Glioma (LGG) and Glioblastoma (GBM) datasets2,>>24<< were downloaded and segregated by IDH1 mutation status and subtype." . _:b595518755 . . _:b595519280 "2"^^ . _:b595518754 . . _:b595519283 "2"^^ . _:b595518765 . . _:b595519282 "2"^^ . _:b595518764 . . . _:b595519293 "2"^^ . _:b595518767 . _:b595519292 "2"^^ . _:b595518766 . _:b595518225 . _:b595519295 "2"^^ . _:b595518761 . . _:b595519294 "2"^^ . _:b595518760 . . _:b595519289 "2"^^ . _:b595518763 . _:b595519288 "2"^^ . _:b595519635 . . _:b595518762 . _:b595519291 "2"^^ . . _:b595518773 . . _:b595519290 "2"^^ . _:b595518772 . _:b595519301 "2"^^ . _:b595518775 . _:b595519300 "2"^^ . _:b595518774 . _:b595519303 "2"^^ . _:b595518769 . . _:b595519302 "2"^^ . _:b595518768 . _:b595519297 "2"^^ . _:b595518771 . . _:b595519549 . _:b595519296 "2"^^ . _:b595518770 . _:b595519299 "2"^^ . _:b595520457 . . . _:b595518781 . . _:b595519298 "2"^^ . _:b595518780 . _:b595519309 "2"^^ . _:b595518783 . . _:b595519308 "2"^^ . _:b595518782 . _:b595519311 "2"^^ . _:b595518777 . _:b595520046 . . . _:b595519310 "2"^^ . _:b595518776 . _:b595519378 . . _:b595519305 "2"^^ . _:b595518779 . . _:b595519304 "2"^^ . _:b595518778 . _:b595519307 "2"^^ . _:b595518789 . . _:b595519306 "2"^^ . _:b595518788 . . _:b595519317 "2"^^ . _:b595518791 . _:b595518332 . _:b595519316 "2"^^ . _:b595518790 . _:b595519319 "2"^^ . _:b595518785 . . _:b595519318 "2"^^ . _:b595518784 . . _:b595519313 "2"^^ . _:b595518787 . _:b595519801 . _:b595519312 "2"^^ . _:b595518786 . _:b595518630 . _:b595519315 "2"^^ . _:b595518797 . . . _:b595519294 . _:b595519314 "2"^^ . _:b595518796 . _:b595519325 "2"^^ . _:b595518799 . _:b595519324 "2"^^ . _:b595518798 . _:b595519327 "2"^^ . _:b595518793 . _:b595519326 "2"^^ . . _:b595518792 . . _:b595519321 "2"^^ . _:b595518795 . _:b595519540 . _:b595519320 "2"^^ . _:b595518794 . _:b595519164 . _:b595519323 "2"^^ . _:b595518805 . _:b595519322 "2"^^ . _:b595519943 . _:b595518804 . _:b595519333 "2"^^ . _:b595518807 . . _:b595519332 "2"^^ . _:b595518806 . _:b595518077 . . _:b595519335 "2"^^ . _:b595518801 . _:b595519300 . _:b595519334 "2"^^ . _:b595518800 . . _:b595519329 "2"^^ . _:b595518803 . _:b595519328 "2"^^ . _:b595518258 . _:b595519543 . _:b595518717 . _:b595518802 . . _:b595519331 "2"^^ . . _:b595518519 . _:b595518813 . _:b595519330 "2"^^ . _:b595518812 . _:b595519341 "2"^^ . _:b595519217 . _:b595518815 . _:b595519340 "2"^^ . _:b595519434 . _:b595518814 . . _:b595518784 . _:b595519343 "2"^^ . _:b595518809 . . . _:b47353803 "Contact domains of IMR90, GM12878, K562 and NHEK cells were obtained from published HiC data>>15<<. Genes were assigned to the inner most domain their transcription start site fell within. Gene pairs were considered to be in the same domain if they were assigned to the same domain in both GM12878 and IMR90. Gene pairs were considered" . _:b595519342 "2"^^ . _:b595518808 . _:b595519337 "2"^^ . _:b595518811 . _:b595519336 "2"^^ . _:b595518810 . _:b595520183 . _:b595518422 . _:b595518259 . _:b595519339 "2"^^ . _:b595518821 . . _:b595520135 . _:b595519499 . _:b595519338 "2"^^ . _:b595520195 . _:b595518820 . _:b595519349 "2"^^ . _:b595518823 . _:b595519348 "2"^^ . _:b595518822 . . _:b595519351 "2"^^ . _:b595518817 . . _:b595519350 "2"^^ . _:b595518816 . _:b595520502 . _:b595520125 . _:b595519345 "2"^^ . _:b595518819 . _:b595519344 "2"^^ . _:b595518818 . _:b595519347 "2"^^ . _:b595518204 . _:b595518829 . . _:b595519346 "2"^^ . _:b595518828 . _:b595518783 . _:b595519357 "2"^^ . _:b595518831 . _:b595519356 "2"^^ . _:b595518830 . _:b595519400 . _:b595519359 "2"^^ . _:b595518825 . _:b595519358 "2"^^ . _:b595518799 . _:b595518824 . _:b595519353 "2"^^ . _:b595518827 . _:b595519352 "2"^^ . . _:b595518826 . _:b595518824 . _:b595519355 "2"^^ . _:b595518837 . _:b595519354 "2"^^ . _:b595518836 . . _:b595518450 . _:b595519365 "2"^^ . _:b595518839 . _:b595518218 . _:b595519364 "2"^^ . _:b595518838 . . . _:b595519367 "2"^^ . _:b595518833 . _:b595519659 . _:b595518825 . _:b595519366 "2"^^ . _:b595518832 . _:b595519361 "2"^^ . _:b595520507 . _:b595518835 . _:b595519125 . _:b595519360 "2"^^ . _:b595518834 . _:b595519363 "2"^^ . _:b595518845 . _:b595519845 . _:b595519362 "2"^^ . _:b595518844 . _:b595520136 . _:b595519373 "2"^^ . _:b595518847 . _:b595519372 "2"^^ . _:b595518846 . _:b595519375 "2"^^ . _:b595518841 . . . _:b595519374 "2"^^ . _:b595518840 . _:b595519369 "2"^^ . _:b595518843 . . . _:b595519368 "2"^^ . _:b595518842 . _:b595519371 "2"^^ . _:b595518853 . _:b595519370 "2"^^ . . _:b595518852 . . . _:b595518722 . . _:b595519381 "2"^^ . _:b595518855 . _:b595519380 "2"^^ . _:b595518854 . . _:b595519383 "2"^^ . _:b595518849 . _:b595519382 "2"^^ . _:b595518848 . _:b595519377 "2"^^ . . _:b595518851 . _:b595519667 . _:b595519997 . _:b595519376 "2"^^ . _:b595518850 . . _:b595519379 "2"^^ . _:b595518861 . _:b595519378 "2"^^ . . _:b595518860 . _:b595519389 "2"^^ . _:b595518863 . _:b595519388 "2"^^ . _:b595518862 . _:b595519391 "2"^^ . _:b595518857 . _:b595519390 "2"^^ . _:b595518856 . _:b595519506 . . _:b595519385 "2"^^ . _:b595520362 . _:b595518859 . _:b595519546 . _:b595519384 "2"^^ . _:b595518858 . _:b595519387 "2"^^ . _:b595518869 . . _:b595519386 "2"^^ . _:b595518868 . . _:b595519397 "2"^^ . _:b595518871 . . _:b595519396 "2"^^ . . _:b595518870 . . _:b595519399 "2"^^ . _:b595518865 . . _:b595518015 . _:b595519398 "2"^^ . _:b595518478 . _:b595518864 . _:b595519393 "2"^^ . _:b595518867 . _:b595519392 "2"^^ . . _:b595518866 . _:b595519342 . _:b595519395 "2"^^ . _:b595519318 . _:b595518877 . . . _:b595519394 "2"^^ . _:b595518876 . . _:b595519405 "2"^^ . _:b595518879 . . . . _:b595519404 "2"^^ . . _:b595518878 . . . _:b595519407 "2"^^ . _:b595518873 . _:b595519406 "2"^^ . _:b595518872 . _:b595519594 . _:b595519185 . _:b595519032 . _:b595519401 "2"^^ . _:b595518875 . _:b595519139 . _:b595519400 "2"^^ . _:b595519756 . _:b595518874 . _:b595519403 "2"^^ . _:b595519580 . _:b595518885 . _:b595520318 . _:b595520333 . _:b595519402 "2"^^ . _:b595518884 . _:b595519070 . _:b595519413 "2"^^ . . _:b595518887 . _:b595519412 "2"^^ . _:b595518886 . . _:b595519415 "2"^^ . . . _:b595518881 . _:b595519414 "2"^^ . _:b47353805 . _:b595518347 . _:b595518880 . . _:b595519409 "2"^^ . _:b595518883 . _:b595519408 "2"^^ . _:b595518882 . _:b595519411 "2"^^ . _:b595518893 . . _:b595519410 "2"^^ . _:b595518892 . _:b595519452 . _:b595519421 "2"^^ . _:b595518895 . _:b595520115 . _:b595519991 . _:b595519420 "2"^^ . _:b595518894 . _:b595519626 . _:b595519423 "2"^^ . _:b595518889 . _:b595519422 "2"^^ . _:b595518888 . _:b595519417 "2"^^ . _:b595518891 . _:b595519416 "2"^^ . _:b595518890 . . . _:b595519419 "2"^^ . _:b595518901 . . _:b595519418 "2"^^ . . _:b595518900 . _:b595519429 "2"^^ . _:b595518903 . _:b595519428 "2"^^ . _:b595518902 . _:b595520512 . _:b595519431 "2"^^ . _:b595518897 . _:b595519534 . . _:b595519430 "2"^^ . _:b595518896 . _:b595519305 . _:b595519425 "2"^^ . _:b595518899 . _:b595519782 . _:b595519736 . _:b595519424 "2"^^ . _:b595518898 . . _:b595519427 "2"^^ . _:b595518909 . _:b595518613 . _:b595518873 . _:b595519426 "2"^^ . _:b595518908 . . _:b595519437 "2"^^ . _:b595518911 . _:b595519436 "2"^^ . _:b595518910 . _:b595519439 "2"^^ . _:b595518905 . _:b595519021 . _:b595520234 . _:b595519438 "2"^^ . _:b595518904 . . _:b595519433 "2"^^ . _:b595518920 . _:b595518907 . _:b595518206 . _:b595519432 "2"^^ . _:b595518906 . _:b595519245 . . _:b595519435 "2"^^ . _:b595518917 . _:b595519434 "2"^^ . _:b595518916 . . _:b595519445 "2"^^ . _:b595518919 . _:b595519444 "2"^^ . _:b595518918 . _:b595519447 "2"^^ . _:b595518913 . . _:b595519446 "2"^^ . . _:b595518912 . . _:b595519441 "2"^^ . _:b595518915 . _:b595519440 "2"^^ . _:b595518914 . . _:b595519443 "2"^^ . _:b595518925 . _:b595519608 . _:b595519912 . _:b595519442 "2"^^ . _:b595518924 . _:b595519453 "2"^^ . _:b595518927 . . _:b595519452 "2"^^ . . _:b595518926 . _:b595519455 "2"^^ . _:b595518921 . _:b595520275 . _:b595519454 "2"^^ . _:b595518920 . _:b595519692 . _:b595519449 "2"^^ . _:b595518923 . . _:b595519448 "2"^^ . _:b47353804 . _:b595518922 . _:b595519451 "2"^^ . _:b595518933 . _:b595519450 "2"^^ . _:b595518932 . _:b595519461 "2"^^ . _:b595518935 . _:b595519460 "2"^^ . _:b595518934 . . _:b595519463 "2"^^ . _:b595518929 . _:b595519327 . _:b595519462 "2"^^ . _:b595518928 . . . _:b595518000 . _:b595519457 "2"^^ . _:b595518931 . . _:b595519679 . _:b595519456 "2"^^ . . _:b595518930 . . _:b595519459 "2"^^ . _:b595518941 . _:b595519458 "2"^^ . _:b595518940 . . _:b595519469 "2"^^ . _:b595518943 . . _:b595519468 "2"^^ . _:b595518942 . . _:b595519815 . _:b595519471 "2"^^ . . _:b595518937 . _:b595519887 . _:b595519470 "2"^^ . _:b595518936 . _:b595519465 "2"^^ . _:b595518939 . _:b595519464 "2"^^ . _:b595518938 . _:b595519946 . . _:b595519467 "2"^^ . _:b595518949 . . . _:b595519466 "2"^^ . _:b595518948 . _:b595519477 "2"^^ . _:b595518951 . . _:b595519476 "2"^^ . _:b595518950 . _:b595519479 "2"^^ . _:b595518945 . _:b595520260 . _:b595519478 "2"^^ . _:b595518944 . _:b595519520 . _:b595520417 . _:b595519473 "2"^^ . _:b595518947 . _:b595519472 "2"^^ . . _:b595518946 . . _:b595519475 "2"^^ . . _:b595518957 . _:b595518736 . _:b595519474 "2"^^ . _:b595518956 . _:b595518841 . . _:b595519485 "2"^^ . . _:b595518160 . _:b595518959 . . _:b595519568 . _:b595519484 "2"^^ . _:b595518958 . _:b595518811 . _:b595519487 "2"^^ . _:b595518953 . _:b595519486 "2"^^ . _:b595518952 . . _:b595519481 "2"^^ . _:b595518955 . _:b595519480 "2"^^ . _:b595518954 . . _:b595519483 "2"^^ . _:b595518965 . _:b595518550 . _:b595518961 . _:b595519482 "2"^^ . . _:b595518964 . _:b595520210 . _:b595519322 . _:b595518492 . _:b595518967 . _:b595518469 "5"^^ . _:b595518966 . _:b595518468 "5"^^ . _:b595518961 . _:b595518471 "5"^^ . _:b595518960 . . _:b595518278 . _:b595520371 . _:b595518470 "5"^^ . _:b595518963 . _:b595518465 "5"^^ . . _:b595518962 . _:b595518464 "5"^^ . _:b595518973 . _:b595518467 "5"^^ . _:b595518972 . _:b595518466 "5"^^ . _:b595518975 . _:b595518267 . _:b595518477 "5"^^ . _:b595518974 . _:b595518715 . _:b595518476 "5"^^ . _:b595518969 . . _:b595520194 . _:b595518479 "5"^^ . _:b595518968 . _:b595518478 "5"^^ . _:b595518808 . _:b595518971 . _:b595518473 "5"^^ . _:b595518525 . _:b595518970 . . _:b595518472 "5"^^ . . _:b595519408 . _:b595518469 . . _:b595518475 "5"^^ . _:b595518880 . _:b595518468 . _:b595519761 . _:b595518474 "5"^^ . . _:b595518471 . _:b595518485 "5"^^ . _:b595518463 . _:b595518470 . _:b595518484 "5"^^ . _:b595518465 . _:b595518487 "5"^^ . _:b595518464 . . _:b595518486 "5"^^ . _:b595518467 . _:b595518481 "5"^^ . _:b595518466 . . _:b595518480 "5"^^ . . _:b595518477 . _:b595518483 "5"^^ . _:b595518476 . . _:b595518482 "5"^^ . . . _:b595518479 . _:b595520340 . _:b595518493 "5"^^ . _:b595518478 . _:b595520387 . _:b595520165 . _:b595518492 "5"^^ . _:b595518473 . 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"28"^^ . _:b595517987 "45"^^ . _:b595517994 . _:b595518014 "28"^^ . . _:b595518005 . _:b595520167 . _:b595518013 "28"^^ . . . _:b595518004 . _:b595520390 . _:b595518012 "29"^^ . _:b595518019 "26"^^ . _:b595518007 . _:b595520410 . _:b595518006 . _:b595518018 "27"^^ . _:b595519153 . _:b595518001 . _:b595518017 "27"^^ . _:b595518000 . _:b595518016 "28"^^ . . . . _:b595518003 . . _:b595518022 "25"^^ . _:b595519025 . _:b595518002 . _:b595518023 "24"^^ . _:b595518013 . . _:b595518020 "25"^^ . _:b595518012 . _:b595518021 "25"^^ . _:b595519859 . _:b595518854 . _:b595518026 "23"^^ . _:b595518015 . _:b595518693 . _:b595518355 . _:b595518014 . _:b595518027 "23"^^ . _:b595518009 . _:b595518416 . _:b595518024 "24"^^ . _:b595518008 . _:b595518025 "23"^^ . . _:b595518030 "22"^^ . _:b595518778 . . _:b595518011 . _:b595518031 "22"^^ . _:b595518010 . _:b595518517 . _:b595518021 . _:b595518028 "23"^^ . . _:b595518029 "22"^^ . _:b595518020 . _:b595518023 . _:b595518033 "21"^^ . _:b595519620 . _:b595518022 . _:b595520011 . _:b595518032 "21"^^ . _:b595518017 . _:b595518035 "21"^^ . _:b595519058 . _:b595518016 . . _:b595518034 "21"^^ . _:b595518019 . _:b595518037 "20"^^ . _:b595519104 . _:b595518018 . _:b595518036 "20"^^ . _:b595518029 . _:b595518039 "20"^^ . _:b595518028 . _:b595518038 "20"^^ . . . _:b595518031 . _:b595518041 "20"^^ . _:b595518030 . _:b595518040 "20"^^ . _:b595518025 . _:b595518043 "20"^^ . _:b595518024 . . _:b595518042 "20"^^ . _:b595518942 . . _:b595518045 "19"^^ . _:b595518027 . _:b595520496 . _:b595518026 . _:b595518044 "19"^^ . _:b595520187 . _:b595518037 . _:b595519826 . _:b595518047 "19"^^ . _:b595518036 . _:b595518046 "19"^^ . _:b595518039 . _:b595518049 "19"^^ . _:b595518272 . _:b595518038 . _:b595518048 "19"^^ . _:b595519596 . . _:b595518051 "18"^^ . _:b595518729 . _:b595518033 . _:b595518050 "18"^^ . _:b595518032 . _:b595518053 "18"^^ . _:b595518035 . _:b595518052 "18"^^ . _:b595518034 . _:b595518108 . _:b595520089 . _:b595518045 . _:b47353807 "For the correlation of FIP1L1 and PDGFRA expression, RNAseq data from the TCGA Lower Grade Glioma (LGG) and Glioblastoma (GBM) datasets>>2<<,24 were downloaded and segregated by IDH1 mutation status and subtype." . _:b595518054 "17"^^ . _:b595518044 . _:b595518055 "17"^^ . _:b595518047 . _:b595518396 . _:b595518056 "17"^^ . _:b595517996 . _:b595518046 . _:b595518646 . _:b595519545 . _:b595518057 "17"^^ . _:b595518483 . _:b595518041 . _:b595519705 . _:b595518058 "17"^^ . _:b595518385 . _:b595518040 . _:b595519256 . _:b595518059 "17"^^ . _:b595518123 . _:b595518043 . _:b595520310 . . _:b595518060 "17"^^ . _:b595518474 . _:b595518042 . . . _:b595518061 "17"^^ . _:b595518053 . _:b595518062 "16"^^ . _:b595518052 . _:b595518063 "16"^^ . _:b595518055 . _:b595518064 "16"^^ . _:b595518054 . . _:b595518065 "16"^^ . _:b595518119 . _:b595518049 . _:b595518066 "16"^^ . _:b595520224 . _:b595518048 . _:b595518067 "16"^^ . _:b595518051 . _:b595518522 . _:b595518068 "16"^^ . _:b595518050 . _:b595518069 "16"^^ 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_:b595518078 . _:b595518343 "6"^^ . _:b595518340 "6"^^ . . _:b595518477 . _:b595518182 . _:b595520061 . _:b595518341 "6"^^ . . _:b595518338 "6"^^ . _:b595518339 "6"^^ . . _:b595518472 . _:b595518336 "6"^^ . _:b595518337 "6"^^ . _:b595519885 . _:b595518350 "6"^^ . . _:b595518351 "6"^^ . _:b595518348 "6"^^ . _:b595518349 "6"^^ . _:b595519877 . _:b595519533 . _:b595518346 "6"^^ . _:b595520193 . . . _:b595518347 "6"^^ . . _:b595518344 "6"^^ . _:b595519345 . _:b595518345 "6"^^ . . _:b595518358 "6"^^ . _:b595518359 "6"^^ . _:b595518356 "6"^^ . . _:b595518357 "6"^^ . _:b595518354 "6"^^ . . _:b595518355 "6"^^ . _:b595518352 "6"^^ . _:b595518353 "6"^^ . . _:b595518366 "6"^^ . _:b595519204 . _:b595518367 "6"^^ . _:b595518584 . _:b595520082 . _:b595518364 "6"^^ . _:b595519589 . _:b595518635 . _:b595518365 "6"^^ . . . _:b595518362 "6"^^ . _:b595519764 . _:b595518363 "6"^^ . . . _:b595518360 "6"^^ . _:b595518361 "6"^^ . _:b595518374 "6"^^ . _:b595520277 . _:b595518375 "6"^^ . . _:b595519510 . 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_:b595518404 "5"^^ . _:b595519920 . _:b595518407 "5"^^ . _:b595519351 . _:b595519961 . _:b595518406 "5"^^ . _:b595518402 "6"^^ . _:b595519462 . _:b595518403 "6"^^ . . _:b595518400 "6"^^ . _:b595518401 "6"^^ . _:b595518600 . _:b595518413 "5"^^ . _:b595519919 . _:b595518412 "5"^^ . . _:b595518415 "5"^^ . . . _:b595519806 . _:b595518414 "5"^^ . _:b595520096 . . _:b595518409 "5"^^ . _:b595519538 . _:b595518408 "5"^^ . . _:b595520071 . . _:b595518411 "5"^^ . _:b595519040 . . _:b595519677 . _:b595518410 "5"^^ . . _:b595518421 "5"^^ . _:b595518420 "5"^^ . . _:b595518423 "5"^^ . _:b595518422 "5"^^ . _:b595518417 "5"^^ . _:b595518416 "5"^^ . _:b595518264 . . _:b595518419 "5"^^ . _:b595518418 "5"^^ . _:b595520466 . _:b595518429 "5"^^ . . _:b595518428 "5"^^ . . _:b595519117 . _:b595518431 "5"^^ . . . _:b595518430 "5"^^ . . _:b595518425 "5"^^ . _:b595518424 "5"^^ . _:b595518427 "5"^^ . _:b595518671 . _:b595518426 "5"^^ . _:b595518437 "5"^^ . _:b595518436 "5"^^ . _:b595520316 . _:b595518439 "5"^^ . _:b595518429 . . _:b595518438 "5"^^ . . . _:b595518433 "5"^^ . _:b595518432 "5"^^ . _:b595518435 "5"^^ . . _:b595518434 "5"^^ . _:b595518445 "5"^^ . _:b595518444 "5"^^ . _:b595518447 "5"^^ . _:b595518446 "5"^^ . . _:b595518330 . _:b595518209 . _:b595518441 "5"^^ . _:b595519437 . _:b595518440 "5"^^ . _:b595518443 "5"^^ . _:b595518442 "5"^^ . . _:b595518453 "5"^^ . . _:b595518452 "5"^^ . . _:b595518455 "5"^^ . _:b595518454 "5"^^ . _:b595518449 "5"^^ . . _:b595518448 "5"^^ . _:b595518451 "5"^^ . _:b595518450 "5"^^ . _:b595518461 "5"^^ . _:b595518460 "5"^^ . . _:b595518463 "5"^^ . _:b595519562 . _:b595518462 "5"^^ . _:b595519595 . _:b595518457 "5"^^ . . _:b595518456 "5"^^ . _:b595519913 . _:b595519660 . _:b595518459 "5"^^ . . _:b595518458 "5"^^ . _:b595519953 . _:b595519956 . _:b595520485 . _:b595518871 . . . . _:b595518458 . . . _:b595520168 . _:b47353815 _:b47353816 . . _:b595518881 . _:b595519571 . . . . _:b595518681 . _:b595519516 . . . . _:b595518146 . _:b595518388 . . . . _:b595519449 . . . _:b595518460 . . . . . . . _:b595520018 . _:b595520401 . _:b595520303 . _:b595519869 . . _:b595520467 . . . _:b595519019 . _:b595518187 . . _:b595518558 . _:b595519814 . _:b595519330 . _:b595519242 . . . _:b595519718 . _:b595518993 . . . . _:b595519298 . _:b595518246 . . _:b595518120 . _:b595518459 . _:b595519103 . . _:b595519045 . _:b595520480 . _:b595519753 . . _:b595520186 . . _:b595519387 . _:b595520034 . . . _:b595519500 . . _:b595518037 . _:b595518655 . . _:b595520462 . _:b595520498 . . _:b595519477 . . . . _:b595520436 . . _:b595519719 . _:b595518069 . _:b595519488 . . _:b595518349 . _:b595519218 . . _:b47353790 _:b47353791 . . . _:b595520110 . _:b595518524 . _:b595518167 . . _:b595519787 . . . _:b595518856 . . _:b47353790 _:b47353812 . _:b47353790 _:b47353813 . _:b47353790 _:b47353814 . _:b47353790 _:b47353808 . _:b47353790 _:b47353809 . _:b47353790 _:b47353810 . _:b47353790 _:b47353811 . _:b595519917 . _:b595519981 . _:b595519519 . _:b47353790 _:b47353804 . _:b47353790 _:b47353805 . _:b47353790 _:b47353806 . _:b47353790 _:b47353807 . _:b47353790 _:b47353800 . _:b47353790 _:b47353801 . _:b47353790 _:b47353802 . . _:b47353790 _:b47353803 . _:b47353790 _:b47353796 . _:b47353790 _:b47353797 . _:b47353790 _:b47353798 . _:b47353790 _:b47353799 . _:b47353790 _:b47353792 . _:b47353790 _:b47353793 . _:b595518957 . _:b47353790 _:b47353794 . . _:b47353790 _:b47353795 . . _:b47353815 "extended data" . . . . _:b595520438 . _:b595518527 . _:b595518351 . _:b595518724 . . _:b595518382 . . _:b595520184 . . _:b595520444 . . . . . . _:b595518380 . . . . . _:b595519441 . . . _:b595519201 . _:b595520235 . . _:b595520083 . . . . _:b595519908 . _:b595519604 . _:b595520290 . _:b595518043 . . _:b595520035 . . . _:b595520181 . . . . . . . _:b595518024 . _:b47353814 . _:b595518424 . _:b595520228 . . _:b595519043 . . _:b595519051 . . _:b595518276 . _:b595518667 . _:b595518066 . _:b595519773 . . _:b595520066 . . _:b595520406 . _:b595519100 . _:b595519693 . . _:b595520067 . _:b595519817 . . _:b595519114 . . . _:b595519459 . _:b595518705 . _:b595520233 . _:b595520177 . _:b595520258 . . _:b595518050 . . . _:b595518539 . _:b595518704 . _:b595519550 . . . . _:b595520331 . . . . _:b595520527 . _:b595518947 . _:b595518867 . _:b595518490 . . . _:b595519197 . _:b595519925 . . . . _:b595519783 . . _:b595518851 . . _:b595520208 . . _:b595520524 . . _:b595518538 . _:b595518678 . . _:b595520244 . _:b595519312 . _:b595518593 . _:b595517983 . _:b595518728 . . . . . . . . . _:b595519429 . _:b595518201 . _:b595519741 . . . . . _:b595520040 . _:b595518057 . _:b595519598 . . _:b595519584 . . . . . . _:b595518321 . . _:b595520027 . _:b595518760 . . _:b595519988 . _:b595518329 . _:b595518470 . _:b595519390 . _:b595520270 . _:b595518252 . _:b595518902 . _:b595519940 . _:b595519381 . . . . _:b47353796 . _:b595520036 . _:b595520430 . . . . . _:b595518071 . . . _:b595518872 . . . . _:b595519391 . _:b595519903 . _:b595518887 . . _:b595518341 . . _:b595519165 . _:b595519831 . . _:b595519949 . _:b595518573 . _:b595519096 . . . . . _:b595518842 . _:b595519251 . . _:b595520185 . . . . _:b595520364 . _:b595518949 . . . . . _:b595519678 . . _:b595520020 . _:b595519094 . _:b595518543 . _:b595519856 . _:b595519873 . _:b595519187 . . . . _:b595520190 . . . _:b595518637 . _:b595520332 . _:b595519910 . . _:b595519427 . . . . . . _:b595518413 . . . _:b595518909 . _:b595518302 . _:b595519501 . . _:b595520021 . . _:b595518059 . . _:b595520182 . _:b595518781 . . . _:b595518238 . . _:b595519411 . _:b595517998 . _:b595520376 . . _:b595518322 . . . . . _:b595520286 . _:b595518624 . . _:b595518181 . . _:b595518255 . _:b595519346 . . . _:b595520350 . _:b595519405 . . . _:b595519399 . _:b595518934 . _:b595518222 . _:b595519592 . _:b595520149 . _:b595520266 . . _:b595518758 . _:b595520159 . . . _:b595518869 . . _:b595520370 . _:b595517997 . . . . _:b595518955 . . . . _:b595518672 . . _:b595518680 . . _:b595519973 . _:b595518866 . . _:b595518531 . . _:b595519466 . _:b595520373 . . . _:b595519890 . . . _:b595519303 . . . _:b595519924 . . . _:b595518301 . . . _:b595520064 . _:b595520057 . . . _:b595519443 . . _:b595519471 . _:b595518328 . . _:b595519075 . . . _:b595518310 . . . . _:b595519952 . . . . _:b595518556 . _:b595519178 . . _:b595518088 . _:b595518280 . _:b595520483 . _:b595520521 . _:b595518197 . _:b595519356 . . . _:b595518313 . _:b595519005 . _:b595518063 . _:b595519133 . _:b595518907 . _:b595518214 . _:b595520130 . _:b595518058 . _:b595518438 . . _:b595518106 . _:b595518097 . . . _:b595520065 . _:b595518158 . _:b595518061 . . _:b595520355 . . . . _:b595519338 . _:b595518632 . . _:b595519603 . . . . _:b595518207 . _:b595519414 . _:b595518755 . _:b595520015 . . _:b595519188 . _:b595518764 . . _:b595518298 . _:b595519739 . _:b595519803 . . . _:b595519755 . . _:b595519688 . _:b595518772 . _:b595520017 . . _:b595518156 . . . _:b595519518 . . . . _:b595519024 . _:b595519091 . _:b595518801 . _:b595520114 . . . . _:b595519576 . _:b595519959 . _:b595519020 . _:b595518994 . _:b595518449 . . . . . . . _:b595520156 . . _:b595519365 . . . . . . _:b595519363 . . _:b595518273 . . . . . . . . . _:b595518199 . _:b595519763 . _:b595519992 . _:b595519320 . . . _:b595519927 . _:b595519837 . _:b595518875 . . _:b595520012 . . _:b595520435 . _:b595519409 . . . . . . . . _:b595520058 . _:b595519637 . _:b595519829 . . . . . _:b595518628 . _:b595519059 . . . _:b595518155 . _:b595518998 . . . _:b595519828 . . _:b595519784 . . _:b595519247 . . . _:b595519030 . . . _:b595518775 . . . . . _:b595518617 . . _:b595518397 . _:b595518574 . _:b47353812 . _:b595519054 . _:b595518905 . _:b47353816 "(a) Expression of FIP1L1 in isolated mouse brain cell types>>44<<. (b) Kaplan-Meier Plot based on TCGA data3 indicates that combined FIP1L1 and PDGFRA expression is a negative prognostic factor in IDH1 mutant lower-grade gliomas." . . . _:b595518188 . _:b595519344 . _:b595520488 . _:b595520378 . _:b595518787 . . . _:b595519362 . _:b595520287 . _:b595518796 . . . . . . _:b595520160 . . _:b595518731 . . . _:b595518770 . . _:b595519235 . . _:b595519641 . _:b595520050 . . . _:b595518708 . . _:b595519886 . . . . _:b595518236 . . . . . _:b595518858 . _:b595519259 . . _:b595518698 . . _:b595520174 . . . _:b595519214 . . _:b595518439 . . . _:b595520411 . . _:b595519744 . . . _:b595518560 . . . . . . _:b595518137 . _:b595519954 . . . . . . _:b595520139 . _:b595519182 . _:b595520455 . . . _:b595518094 . _:b595518493 . . _:b595519288 . . _:b595518710 . _:b595518652 . _:b595518668 . _:b595519329 . . _:b595519662 . . _:b595519615 . _:b595518604 . . . _:b595520385 . . . . _:b595520248 . _:b595519590 . _:b595518281 . . _:b595519805 . _:b595520226 . . . _:b595518457 . . . . _:b595519830 . . _:b595519194 . . . _:b595518117 . . _:b595518988 . . _:b595519052 . . . . _:b595518447 . . _:b595518883 . . . _:b595518131 . _:b595519239 . _:b595519707 . . _:b47353791 "IDH1 status was determined for all clinical samples by SNaPshot multiplex PCR>>31<<. PDGFRA status was confirmed by FISH analysis. Tissue (200\u2013500 \u03BCg) was mechanically minced with a sterile razor blade prior to further processing." . _:b595519339 . . . _:b595518229 . _:b595519186 . _:b595518414 . _:b595519851 . _:b595520028 . . . . _:b595520158 . _:b595519601 . _:b595519289 . _:b595518821 . . . . . . _:b595520141 . _:b595518735 . . . . . . . _:b595518506 . _:b595519105 . . _:b595519270 . . . . . _:b595518996 . . . _:b47353811 . . _:b595519026 . . . _:b595518798 . _:b595519291 . . . . . _:b595518761 . . _:b47353811 "Bisulfite converted DNA specific to the CTCF binding site (defined by JASPAR>>40<<) in the boundary adjacent to PDGFRA was amplified using the following primers F:" . _:b595518542 . . _:b595519629 . . . . _:b595520178 . . _:b595518363 . _:b595520394 . _:b595518845 . _:b595518977 . . . . _:b595520464 . _:b595519067 . . _:b595519572 . . _:b595520384 . _:b595518338 . . _:b595518797 . _:b595520221 . . . _:b595518802 . _:b595519272 . _:b595518643 . _:b595519593 . _:b595519011 . _:b595519237 . _:b595519268 . . _:b595520254 . _:b595518742 . _:b595518645 . . _:b595519554 . _:b595519359 . _:b595518079 . . _:b595519743 . _:b595518356 . . _:b595519575 . _:b595519444 . . _:b595518198 . . . . . . . _:b595520461 . . . _:b595519135 . . . _:b595519820 . . _:b595519883 . _:b595520300 . _:b595518663 . . . . _:b595519904 . _:b595518629 . _:b595519957 . _:b595518697 . _:b595519199 . . _:b595519716 . . _:b595519455 . _:b595519726 . . _:b595520086 . _:b595519227 . . _:b595520400 . . . . . . _:b595520204 . _:b595519041 . _:b595519101 . _:b595520356 . _:b595518540 . . _:b595520305 . . _:b595519064 . _:b595518777 . . . _:b595520211 . _:b595519746 . _:b595519674 . . . . . . . . _:b595519314 . _:b595518488 . _:b595519900 . _:b595518748 . _:b595518548 . _:b595517989 . . _:b595519176 . . _:b595518366 . _:b595518927 . . _:b595518282 . . . _:b595520237 . _:b595518287 . _:b595518189 . . _:b595518392 . _:b595519934 . . . . . _:b595519029 . . . . _:b595519146 . _:b595518954 . _:b595520472 . . . . . . _:b595518018 . _:b595518509 . . . . . _:b595518115 . . _:b595519686 . _:b595519353 . . . _:b595518773 . . _:b595520397 . _:b595520274 . _:b595518719 . . _:b595518003 . . _:b595520074 . _:b595518917 . _:b595518153 . . . _:b595520113 . . _:b595518502 . _:b595520123 . _:b595518529 . _:b595519709 . . . . _:b595518932 . _:b595518564 . . _:b595520119 . . _:b595519177 . . . _:b595517995 . . _:b595519628 . _:b595518598 . _:b595519456 . . _:b595519548 . _:b595520077 . _:b595518738 . _:b595520439 . . _:b47353800 "RNA-seq data for 357 normal brain samples was downloaded from GTEx>>20<<. RNA-seq data and copy number profiles for lower grade gliomas were downloaded from TCGA23,24." . . _:b595519281 . _:b595520325 . . _:b595518249 . . . . _:b595520041 . _:b595519221 . . . _:b595519077 . _:b595518674 . _:b595519836 . . _:b595520328 . . . . . _:b595520415 . _:b595519790 . _:b595519389 . _:b595517980 . _:b595520517 "2"^^ . . _:b595520471 . _:b595520516 "2"^^ . _:b595519472 . . _:b595520519 "2"^^ . . _:b595520518 "2"^^ . . _:b595520513 "2"^^ . . . _:b595520512 "2"^^ . _:b595518837 . _:b595520515 "2"^^ . _:b595518268 . _:b595520514 "2"^^ . _:b595519938 . _:b595519541 . _:b595520525 "2"^^ . _:b595520524 "2"^^ . _:b595519385 . _:b595520527 "2"^^ . _:b595520526 "2"^^ . _:b595520521 "2"^^ . _:b595520520 "2"^^ . _:b595519140 . _:b595520523 "2"^^ . _:b595520517 . _:b595520522 "2"^^ . _:b595519691 . _:b595520516 . _:b595520519 . . _:b595520518 . _:b595520513 . . _:b595519209 . . _:b595520512 . _:b595520529 "2"^^ . _:b595520515 . _:b595520528 "2"^^ . _:b595520514 . _:b595520531 "2"^^ . _:b595520525 . _:b595520530 "2"^^ . . _:b595520524 . _:b595519839 . _:b595520527 . _:b595518695 . . _:b595520526 . _:b595520521 . _:b595520520 . _:b595520523 . _:b595520522 . _:b595519511 . _:b47353810 "org/juicebox/)>>15<<. Data shown is from the IMR90 cell line at 5kb resolution, normalized to coverage." . _:b595518233 . _:b595520529 . . _:b595520528 . . _:b595520531 . _:b595520530 . . _:b47353803 . . . _:b595518925 . _:b595519612 . . . _:b47353809 . _:b47353810 . . . _:b595520241 . . _:b595520381 . _:b595518340 . _:b595520132 . . . _:b595519158 . . . . _:b595519945 . _:b595518569 . . _:b595518812 . _:b595518549 . . _:b595520023 . . . . _:b595520279 . . _:b595518741 . _:b595519073 . . . _:b595518446 . . _:b595519701 . _:b595518299 . . _:b595518625 . _:b595518611 . _:b47353793 "Gliomaspheres were maintained in culture as described32,>>33<<. Briefly, neurosphere cultures contain Neurobasal media supplemented with 20 ng/mL recombinant EGF (R and D Systems), 20ng/mL FGF2 (R and D Systems), 1X B27 supplement (Invitrogen), 0.5X N2 supplement (Invitrogen), 3mM L-glutamine, and" . . _:b595520312 . _:b595518720 . _:b595519311 . . . _:b595520307 . _:b595518882 . . _:b595519644 . . . . _:b595519751 . _:b595519436 . _:b595518840 . _:b595519415 . _:b47353793 . _:b595519986 . . _:b595519253 . . _:b47353794 . _:b595518732 . _:b595518323 . . . _:b595519513 . _:b595519412 . _:b595519233 . . _:b595518827 . _:b595520220 . _:b595518336 . _:b595519038 . . _:b595519275 . . . _:b595519797 . _:b595520494 . _:b595518030 . _:b595519445 . _:b595518786 . _:b595518138 . _:b595519271 . . . _:b595518806 . _:b595518270 . _:b595519653 . _:b595519824 . _:b595519865 . _:b595518451 . . . . . _:b595520445 . . . _:b595518335 . . _:b595519789 . . . . _:b47353806 "In addition to PDGFRA, top ranking genes include CHD4 (p<10\u221232), a driver of glioblastoma tumor initiation38, L1CAM (p<10\u22128), a regulator of the glioma stem cells and tumor growth>>39<<, and other candidate regulators (Supplemental Table 1)." . _:b595518779 . . _:b595518266 . . . . . _:b595518948 . . _:b595519037 . . _:b595520469 . . . _:b595519777 . . _:b595518012 . _:b595518644 . _:b595519759 . . . . . . . _:b595519915 . . . _:b595518055 . . _:b595520449 . _:b595519563 . . _:b595518139 . . . _:b595518163 . _:b595519776 . . _:b595519765 . . . _:b595518800 . . . _:b595518103 . . . _:b595518358 . _:b595519078 . . . . _:b595519446 . _:b595519180 . . _:b595519906 . . . . _:b595519079 . . . . _:b595520425 . . . _:b595518507 . . _:b595519737 . _:b595520422 . . . _:b595518253 . . _:b595518482 . . _:b595519277 . _:b595518484 . _:b595520330 . . . . . _:b595519082 . _:b595519377 . _:b595519582 . . . . _:b595519556 . . _:b595518045 . . _:b595520155 . . . . _:b595520146 . _:b595518649 . _:b595519834 . _:b595519666 . . _:b595520273 . _:b595518561 . _:b595519663 . _:b595519570 . _:b47353804 "We considered all domains and boundaries scored in IMR90 HiC data>>13<<. Gene pairs crossing a CTCF peak and an IMR90 boundary (i.e. can be assigned to different domains) that were significantly more correlated in IDH mutant tumors were considered to support the loss of that boundary." . _:b595518709 . _:b595519213 . _:b595518903 . . . _:b595519507 . _:b595518946 . _:b595519224 . _:b595518421 . _:b595518939 . _:b595519119 . _:b595520336 . _:b595520127 . . . . _:b595520261 . _:b595520260 . . _:b595520263 . _:b595520262 . _:b595519980 . _:b595520257 . _:b595518963 . _:b595520256 . _:b595520259 . . _:b595520258 . . . _:b595520269 . _:b595519617 . . _:b595520268 . . _:b595520271 . _:b595520270 . _:b595520265 . _:b595518101 . _:b595520264 . . . _:b595520267 . _:b595520266 . _:b595519419 . _:b595520277 . _:b595519123 . _:b595520276 . _:b595520151 . _:b595520279 . _:b595519492 . _:b595520278 . _:b595520273 . _:b595519841 . _:b595520272 . _:b595520203 . _:b595520288 . _:b595519902 . _:b595520275 . _:b595520274 . . _:b595520285 . _:b595520284 . _:b595520264 . . _:b595520287 . _:b595520286 . _:b595520281 . . _:b595520280 . _:b595518467 . _:b595519699 . . _:b595520283 . _:b595520282 . _:b595519521 . _:b595519001 . _:b595520293 . _:b595520292 . _:b595520441 . _:b595519171 . _:b595520295 . _:b595520294 . _:b595519966 . . _:b595520289 . _:b595519850 . . _:b595520288 . _:b595520291 . _:b595520290 . _:b595520327 . _:b595520301 . . _:b595520300 . _:b595520303 . . _:b595520302 . . _:b595520297 . _:b595518757 . _:b595520296 . . _:b595520299 . _:b595518555 . _:b595520298 . _:b595520309 . _:b595519093 . _:b595520308 . _:b595520311 . . _:b595519936 . _:b595520310 . . . . _:b595519388 . _:b595520305 . _:b595518031 . _:b595520304 . . _:b595520307 . _:b595518150 . _:b595520306 . _:b595518618 . _:b595520153 . _:b595520317 . . _:b595520316 . _:b595520319 . _:b595518333 . . _:b595520318 . _:b595520313 . _:b595519821 . _:b595520312 . _:b595520315 . _:b595520314 . _:b595520325 . _:b595520324 . . . . _:b595520327 . _:b595520326 . _:b595518615 . _:b595520321 . . . . _:b595519531 . _:b595520320 . _:b595520296 . _:b595520323 . _:b595520078 . . _:b595520322 . . _:b595520379 . _:b595520333 . _:b595518196 . _:b595519375 . _:b595520332 . _:b595518053 . _:b595520335 . _:b595520334 . _:b595520162 . _:b595520329 . _:b595518844 . _:b595520328 . _:b595520331 . . _:b595520330 . _:b595520341 . . _:b595518215 . _:b595520340 . _:b595520343 . _:b595519857 . _:b595520342 . . _:b595520337 . _:b595519969 . _:b595520336 . . _:b595520339 . _:b595519983 . _:b595520338 . . _:b595520349 . _:b595520348 . . _:b595520351 . _:b595520350 . _:b595519780 . . _:b595520345 . _:b595518318 . _:b595520344 . _:b595519881 . _:b595519788 . . _:b595520347 . . _:b595518523 . _:b595520346 . _:b595519781 . _:b595519645 . _:b595520357 . _:b595520356 . _:b595519749 . _:b595520359 . _:b595520447 . _:b595520358 . _:b595520353 . . _:b595520352 . _:b595520355 . . . . _:b595520354 . _:b595518157 . _:b595520365 . _:b595520049 . _:b595519838 . _:b595520364 . _:b595520367 . . . _:b595520366 . 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