This HTML5 document contains 4648 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
xsdhhttp://www.w3.org/2001/XMLSchema#
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n8http://togows.dbcls.jp/entry/pubmed/
bibohttp://purl.org/ontology/bibo/
n9http://dx.doi.org/
n4http://purl.org/spar/doco/
dchttp://purl.org/dc/elements/1.1/
n10http://pubannotation.org/docs/sourcedb/PMC/sourceid/
rdfshttp://www.w3.org/2000/01/rdf-schema#
n2http://purl.jp/bio/10/colil/ontology/201303#
n11http://www.ncbi.nlm.nih.gov/pmc/articles/
n3http://purl.jp/bio/10/colil/id/

Statements

Subject Item
n3:27522506
rdf:type
n2:CitationPaper n2:RelevantPaper n2:ReferencePaper
rdfs:seeAlso
n8:27522506 n9:10.1007%2Fs00401-016-1606-5 n10:0 n11:0
bibo:cites
n3:23695293 n3:3971148 n3:15748959 n3:22366759 n3:3734882 n3:25309322 n3:25894876 n3:6742132 n3:24818670 n3:22064427 n3:22287710 n3:18830405 n3:16585265 n3:7668828 n3:24316973 n3:26975356 n3:10365103 n3:9306968 n3:1694970 n3:10994852 n3:1373020 n3:24590280 n3:18923183 n3:9418990 n3:12658277 n3:25814152 n3:15931259 n3:18711435 n3:15894540 n3:15943078 n3:19918869 n3:21259015 n3:26656646 n3:2860501 n3:23609350 n3:24565479 n3:11596127 n3:18496841 n3:22896675 n3:22848551 n3:2413113 n3:22162058 n3:1463583 n3:24252464 n3:25285078 n3:3374751 n3:26358409 n3:21040844 n3:7630927 n3:18865105 n3:21300915 n3:25345857 n3:11518729 n3:11371357 n3:23172993 n3:26030524 n3:19050840 n3:2254158 n3:26077718 n3:7510047 n3:1720138 n3:15186921 n3:14734524 n3:20483748 n3:15735653 n3:26435380 n3:9736023 n3:24828040 n3:25100740 n3:25100741 n3:27338806 n3:11138923 n3:25712734 n3:25521178 n3:20817872 n3:24145049 n3:11524285 n3:15939794 n3:12044977 n3:18802067 n3:12731042 n3:23624600 n3:1669702 n3:3796814 n3:22030551 n3:26876174 n3:22926201 n3:18208483 n3:9550136 n3:24740164 n3:19305396 n3:25797609 n3:17091291 n3:1722030 n3:19023878 n3:12421916 n3:25587368 n3:25421634 n3:26383824 n3:22031325 n3:11823530 n3:22291210 n3:7223889 n3:345773 n3:22855606 n3:19234858 n3:9973470 n3:12662319 n3:23818064 n3:16972896 n3:17129764 n3:12829791 n3:12714572 n3:23685843 n3:3826655 n3:22903150 n3:3392571 n3:23489283 n3:18000062 n3:25102344 n3:1341962 n3:16112683 n3:21910991 n3:19829296 n3:1613459 n3:25545837 n3:26863192 n3:22170742 n3:760365 n3:16204309 n3:12595306 n3:2180767 n3:22914092 n3:16885505 n3:26399987 n3:25673843 n3:23413811 n3:21349152
n2:cocitationWith
n3:3971148 n3:29570159 n3:30643288 n3:28862640 n3:32917953 n3:33911285 n3:31461408 n3:9728088 n3:11294783 n3:23695293 n3:15679948 n3:28459441 n3:18215617 n3:25828099 n3:29437767 n3:30740048 n3:24305823 n3:28135240 n3:28029927 n3:28627037 n3:22366799 n3:29903035 n3:19339255 n3:22366759 n3:20619340 n3:28228568 n3:25561720 n3:11860459 n3:26869887 n3:22632727 n3:22759265 n3:10696507 n3:31915375 n3:21516112 n3:25136634 n3:21349439 n3:21148344 n3:27234656 n3:24440640 n3:22064427 n3:21737504 n3:6742132 n3:28636961 n3:28636962 n3:20944625 n3:20944627 n3:26105538 n3:31757960 n3:29101220 n3:22287710 n3:15930352 n3:23400708 n3:27459405 n3:29428972 n3:7062119 n3:29397420 n3:15931160 n3:18007663 n3:15294142 n3:3950724 n3:28526764 n3:23316936 n3:16281912 n3:18604199 n3:33446503 n3:26998085 n3:10852536 n3:28853674 n3:16585265 n3:27135602 n3:25678956 n3:27239529 n3:8596936 n3:24936446 n3:20197061 n3:31821174 n3:12843411 n3:26733797 n3:30602786 n3:28598415 n3:22393530 n3:24316888 n3:27540165 n3:27540163 n3:29618808 n3:25278937 n3:29653606 n3:26975356 n3:25891508 n3:21291474 n3:10911963 n3:30280653 n3:29627873 n3:5957959 n3:27460561 n3:27608759 n3:31916277 n3:27496004 n3:26590417 n3:25765070 n3:29443965 n3:27409813 n3:24625825 n3:26245965 n3:25900222 n3:16960091 n3:19111869 n3:20142990 n3:17619996 n3:23007702 n3:29368214 n3:11311463 n3:17619998 n3:31932797 n3:15048884 n3:25589753 n3:9418990 n3:1373020 n3:24227727 n3:16039904 n3:25589747 n3:19132915 n3:17828272 n3:20738866 n3:18923183 n3:24601941 n3:26846644 n3:26682987 n3:29754206 n3:21990350 n3:29996134 n3:17036005 n3:8370472 n3:27776109 n3:22037947 n3:29740121 n3:25399804 n3:26323545 n3:18809917 n3:31042697 n3:19226510 n3:17077814 n3:26661250 n3:21259015 n3:28099414 n3:17438020 n3:26713745 n3:27337340 n3:3551211 n3:12010739 n3:25329858 n3:26661200 n3:10858586 n3:24336108 n3:4366438 n3:25823458 n3:23609350 n3:23298378 n3:11596125 n3:26195256 n3:23126372 n3:23575640 n3:85446 n3:1928403 n3:16011870 n3:32213628 n3:29053035 n3:26995317 n3:22714021 n3:26463008 n3:18496841 n3:25727254 n3:26546453 n3:22664787 n3:22896675 n3:10818495 n3:31132378 n3:1463583 n3:17638898 n3:26353940 n3:6155466 n3:21068832 n3:21169520 n3:15193029 n3:20654699 n3:22252717 n3:16799555 n3:11807399 n3:17620468 n3:26153041 n3:31178118 n3:26524530 n3:16567637 n3:27096319 n3:22811424 n3:27916653 n3:15489380 n3:28043954 n3:29755681 n3:27582220 n3:25727737 n3:26284939 n3:19002474 n3:28138136 n3:19664713 n3:25285078 n3:16866984 n3:28883786 n3:28446786 n3:23136223 n3:10408445 n3:22968321 n3:31270459 n3:21149252 n3:24029635 n3:23307741 n3:24366271 n3:21040844 n3:20056930 n3:20047691 n3:18865105 n3:21300915 n3:3614542 n3:21738161 n3:28470822 n3:20924629 n3:27729857 n3:16476660 n3:4137563 n3:33508229 n3:8669469 n3:27530322 n3:28855621 n3:19346498 n3:15100718 n3:29141865 n3:28229893 n3:16806499 n3:25862573 n3:19779720 n3:26030524 n3:18676439 n3:28031395 n3:26619118 n3:16174293 n3:27980126 n3:18873158 n3:28161508 n3:28715552 n3:26376966 n3:25580734 n3:23160197 n3:19533601 n3:27141424 n3:20129251 n3:27025652 n3:2254158 n3:23635358 n3:19050840 n3:27141419 n3:23812703 n3:17715340 n3:25355681 n3:7510047 n3:28826498 n3:26903861 n3:28844499 n3:26077718 n3:14704766 n3:16936277 n3:21387374 n3:19104149 n3:30598527 n3:29106980 n3:20851191 n3:19169263 n3:31341278 n3:27403742 n3:28969373 n3:28371827 n3:29025771 n3:16698083 n3:26030851 n3:21498572 n3:8347303 n3:14734524 n3:15186921 n3:20439540 n3:29283289 n3:21701599 n3:24670647 n3:32001524 n3:28117416 n3:17121744 n3:15846794 n3:27327500 n3:23481704 n3:24552317 n3:23160472 n3:28961037 n3:25078775 n3:25995466 n3:29873694 n3:8963753 n3:23187627 n3:12743111 n3:19018243 n3:16650807 n3:20725515 n3:31157827 n3:27358487 n3:21149665 n3:23233386 n3:31051162 n3:20976767 n3:12433975 n3:25340933 n3:30353860 n3:15735653 n3:19260033 n3:9736023 n3:25361776 n3:16960575 n3:23443171 n3:28302766 n3:3117606 n3:17487182 n3:30651548 n3:25792098 n3:18553315 n3:10537110 n3:29127332 n3:28396408 n3:21371012 n3:24828040 n3:28188218 n3:30310148 n3:27214551 n3:17522861 n3:15758009 n3:25653369 n3:25100741 n3:30224810 n3:29420261 n3:11923409 n3:16355212 n3:26690495 n3:27852330 n3:25704809 n3:23653359 n3:28235764 n3:20610345 n3:16732273 n3:12876559 n3:16365086 n3:25307057 n3:28860328 n3:32376954 n3:24357543 n3:23150934 n3:12417434 n3:28002679 n3:21296405 n3:25002752 n3:11901243 n3:27338705 n3:15717053 n3:19269895 n3:27551677 n3:22048062 n3:30326293 n3:32621291 n3:590401 n3:20178740 n3:21839917 n3:23752249 n3:26952098 n3:29518260 n3:22144466 n3:22829269 n3:26300732 n3:25378163 n3:25521178 n3:28716371 n3:29377008 n3:17272818 n3:24145049 n3:31332391 n3:23867200 n3:28798076 n3:20565964 n3:16025095 n3:29195051 n3:25888557 n3:22150037 n3:30747918 n3:1566067 n3:3796814 n3:19129672 n3:22030551 n3:24583233 n3:18698034 n3:25947369 n3:9883839 n3:26247808 n3:28288125 n3:23412074 n3:16775224 n3:24045166 n3:20966214 n3:28552391 n3:24566916 n3:26748031 n3:23334579 n3:28003545 n3:22926201 n3:20179016 n3:19164813 n3:22226359 n3:12794167 n3:25257319 n3:18208483 n3:26912648 n3:19954936 n3:16540683 n3:29061693 n3:15056293 n3:19046364 n3:31604244 n3:11958825 n3:17470760 n3:12130773 n3:23434588 n3:21757525 n3:1713524 n3:28758994 n3:29988793 n3:18182301 n3:16166562 n3:27514673 n3:19305396 n3:23462419 n3:28292436 n3:22022637 n3:19868782 n3:25448765 n3:12640446 n3:23420871 n3:29391404 n3:29089479 n3:25687367 n3:26499397 n3:29426702 n3:25417164 n3:27601434 n3:25287860 n3:26084936 n3:29752066 n3:19023878 n3:29400711 n3:7356021 n3:31883839 n3:12421916 n3:24583950 n3:12612547 n3:27929105 n3:25908461 n3:25421634 n3:17388955 n3:28971799 n3:21778362 n3:28541408 n3:26312599 n3:8419962 n3:29681904 n3:24012647 n3:23597431 n3:21840891 n3:30760929 n3:20720507 n3:11557630 n3:22291210 n3:15831717 n3:12834104 n3:26711460 n3:27543501 n3:27001570 n3:22622580 n3:28938276 n3:32413299 n3:25204284 n3:22907116 n3:28092374 n3:18359102 n3:25972006 n3:25274032 n3:7223889 n3:7223890 n3:345773 n3:25096616 n3:26327684 n3:15067033 n3:24925914 n3:25471560 n3:19306372 n3:16230320 n3:23039106 n3:18083105 n3:26583089 n3:16636173 n3:30269986 n3:12578225 n3:27027288 n3:23477737 n3:24309662 n3:11222803 n3:17682068 n3:10499794 n3:15695511 n3:30104766 n3:23818064 n3:16636135 n3:22615835 n3:25186741 n3:8987746 n3:25991443 n3:23709744 n3:17129764 n3:19828616 n3:31078957 n3:23858432 n3:6411905 n3:31235908 n3:11240037 n3:24559670 n3:30471926 n3:23152628 n3:10655103 n3:25398455 n3:12829791 n3:16972896 n3:28092660 n3:26993511 n3:26442694 n3:26993512 n3:11810184 n3:30076374 n3:30815987 n3:29039724 n3:22932670 n3:21886162 n3:6658996 n3:25982749 n3:25757756 n3:29344300 n3:17846148 n3:24946077 n3:28426845 n3:11558796 n3:19714497 n3:27462115 n3:19265055 n3:18619524 n3:27725773 n3:15956523 n3:28886007 n3:30340601 n3:9211853 n3:30250261 n3:25003359 n3:5765759 n3:23553482 n3:18026096 n3:30420755 n3:26431936 n3:24916913 n3:24817998 n3:31942068 n3:22903149 n3:22903150 n3:26603901 n3:23489283 n3:24848101 n3:19201002 n3:24418464 n3:1341963 n3:22857991 n3:23692610 n3:30389931 n3:17302889 n3:26973460 n3:1341962 n3:16199517 n3:10527772 n3:32094487 n3:6886750 n3:32094452 n3:22722893 n3:33462448 n3:31063132 n3:25013150 n3:19648929 n3:10037799 n3:10934227 n3:30150661 n3:19786543 n3:17140851 n3:15195085 n3:21779395 n3:21944997 n3:27721430 n3:27836940 n3:7910634 n3:12486269 n3:19349616 n3:26005850 n3:28957666 n3:19829296 n3:26718201 n3:16547515 n3:29339443 n3:16371949 n3:31322758 n3:15141078 n3:24103194 n3:29610928 n3:18375385 n3:28193695 n3:17483690 n3:11381080 n3:26863192 n3:16415867 n3:26775912 n3:29387036 n3:18363936 n3:22466658 n3:3276004 n3:24569378 n3:27920202 n3:29162645 n3:22442384 n3:24285616 n3:27810172 n3:24137023 n3:21799171 n3:30046111 n3:6685237 n3:19028999 n3:24088808 n3:16204309 n3:19019972 n3:25611508 n3:28939709 n3:24136970 n3:27443914 n3:16793937 n3:20081185 n3:12430718 n3:27227366 n3:12412020 n3:28903061 n3:23945592 n3:26745839 n3:31165009 n3:11120756 n3:15668734 n3:27697546 n3:15256471 n3:22914092 n3:10190820 n3:23335631 n3:16399703 n3:23650139 n3:25205593 n3:25190438 n3:22718543 n3:21995440 n3:24162737 n3:28567588 n3:26687840 n3:25392494 n3:26687838 n3:16885505 n3:20468051 n3:27033548 n3:24162655 n3:23413811 n3:23602162 n3:28847942 n3:26884166 n3:26090084 n3:25112380 n3:25673843 n3:24056773 n3:28916821 n3:23296339 n3:26471369 n3:21349152 n3:21280082 n3:29023798 n3:20107219 n3:29091775
n2:hasRelevantBibliographicResourceOf
_:vb611582452 _:vb611582453 _:vb611582454 _:vb611582455 _:vb611582448 _:vb611582449 _:vb611582450 _:vb611582451 _:vb611582460 _:vb611582461 _:vb611582462 _:vb611582463 _:vb611582456 _:vb611582457 _:vb611582458 _:vb611582459 _:vb611582436 _:vb611582437 _:vb611582438 _:vb611582439 _:vb611582432 _:vb611582433 _:vb611582434 _:vb611582435 _:vb611582444 _:vb611582445 _:vb611582446 _:vb611582447 _:vb611582440 _:vb611582441 _:vb611582442 _:vb611582443 _:vb611582420 _:vb611582421 _:vb611582422 _:vb611582423 _:vb611582418 _:vb611582419 _:vb611582428 _:vb611582429 _:vb611582430 _:vb611582431 _:vb611582424 _:vb611582425 _:vb611582426 _:vb611582427 _:vb611582708 _:vb611582709 _:vb611582710 _:vb611582711 _:vb611582704 _:vb611582705 _:vb611582706 _:vb611582707 _:vb611582716 _:vb611582717 _:vb611582718 _:vb611582719 _:vb611582712 _:vb611582713 _:vb611582714 _:vb611582715 _:vb611582692 _:vb611582693 _:vb611582694 _:vb611582695 _:vb611582688 _:vb611582689 _:vb611582690 _:vb611582691 _:vb611582700 _:vb611582701 _:vb611582702 _:vb611582703 _:vb611582696 _:vb611582697 _:vb611582698 _:vb611582699 _:vb611582676 _:vb611582677 _:vb611582678 _:vb611582679 _:vb611582672 _:vb611582673 _:vb611582674 _:vb611582675 _:vb611582684 _:vb611582685 _:vb611582686 _:vb611582687 _:vb611582680 _:vb611582681 _:vb611582682 _:vb611582683 _:vb611582660 _:vb611582661 _:vb611582662 _:vb611582663 _:vb611582656 _:vb611582657 _:vb611582658 _:vb611582659 _:vb611582668 _:vb611582669 _:vb611582670 _:vb611582671 _:vb611582664 _:vb611582665 _:vb611582666 _:vb611582667 _:vb611582644 _:vb611582645 _:vb611582646 _:vb611582647 _:vb611582640 _:vb611582641 _:vb611582642 _:vb611582643 _:vb611582652 _:vb611582653 _:vb611582654 _:vb611582655 _:vb611582648 _:vb611582649 _:vb611582650 _:vb611582651 _:vb611582628 _:vb611582629 _:vb611582630 _:vb611582631 _:vb611582624 _:vb611582625 _:vb611582626 _:vb611582627 _:vb611582636 _:vb611582637 _:vb611582638 _:vb611582639 _:vb611582632 _:vb611582633 _:vb611582634 _:vb611582635 _:vb611582612 _:vb611582613 _:vb611582614 _:vb611582615 _:vb611582608 _:vb611582609 _:vb611582610 _:vb611582611 _:vb611582620 _:vb611582621 _:vb611582622 _:vb611582623 _:vb611582616 _:vb611582617 _:vb611582618 _:vb611582619 _:vb611582596 _:vb611582597 _:vb611582598 _:vb611582599 _:vb611582592 _:vb611582593 _:vb611582594 _:vb611582595 _:vb611582604 _:vb611582605 _:vb611582606 _:vb611582607 _:vb611582600 _:vb611582601 _:vb611582602 _:vb611582603 _:vb611582580 _:vb611582581 _:vb611582582 _:vb611582583 _:vb611582576 _:vb611582577 _:vb611582578 _:vb611582579 _:vb611582588 _:vb611582589 _:vb611582590 _:vb611582591 _:vb611582584 _:vb611582585 _:vb611582586 _:vb611582587 _:vb611582564 _:vb611582565 _:vb611582566 _:vb611582567 _:vb611582560 _:vb611582561 _:vb611582562 _:vb611582563 _:vb611582572 _:vb611582573 _:vb611582574 _:vb611582575 _:vb611582568 _:vb611582569 _:vb611582570 _:vb611582571 _:vb611582548 _:vb611582549 _:vb611582550 _:vb611582551 _:vb611582544 _:vb611582545 _:vb611582546 _:vb611582547 _:vb611582556 _:vb611582557 _:vb611582558 _:vb611582559 _:vb611582552 _:vb611582553 _:vb611582554 _:vb611582555 _:vb611582532 _:vb611582533 _:vb611582534 _:vb611582535 _:vb611582528 _:vb611582529 _:vb611582530 _:vb611582531 _:vb611582540 _:vb611582541 _:vb611582542 _:vb611582543 _:vb611582536 _:vb611582537 _:vb611582538 _:vb611582539 _:vb611582516 _:vb611582517 _:vb611582518 _:vb611582519 _:vb611582512 _:vb611582513 _:vb611582514 _:vb611582515 _:vb611582524 _:vb611582525 _:vb611582526 _:vb611582527 _:vb611582520 _:vb611582521 _:vb611582522 _:vb611582523 _:vb611582500 _:vb611582501 _:vb611582502 _:vb611582503 _:vb611582496 _:vb611582497 _:vb611582498 _:vb611582499 _:vb611582508 _:vb611582509 _:vb611582510 _:vb611582511 _:vb611582504 _:vb611582505 _:vb611582506 _:vb611582507 _:vb611582484 _:vb611582485 _:vb611582486 _:vb611582487 _:vb611582480 _:vb611582481 _:vb611582482 _:vb611582483 _:vb611582492 _:vb611582493 _:vb611582494 _:vb611582495 _:vb611582488 _:vb611582489 _:vb611582490 _:vb611582491 _:vb611582468 _:vb611582469 _:vb611582470 _:vb611582471 _:vb611582464 _:vb611582465 _:vb611582466 _:vb611582467 _:vb611582476 _:vb611582477 _:vb611582478 _:vb611582479 _:vb611582472 _:vb611582473 _:vb611582474 _:vb611582475 _:vb611582964 _:vb611582965 _:vb611582966 _:vb611582967 _:vb611582960 _:vb611582961 _:vb611582962 _:vb611582963 _:vb611582972 _:vb611582973 _:vb611582974 _:vb611582975 _:vb611582968 _:vb611582969 _:vb611582970 _:vb611582971 _:vb611582948 _:vb611582949 _:vb611582950 _:vb611582951 _:vb611582944 _:vb611582945 _:vb611582946 _:vb611582947 _:vb611582956 _:vb611582957 _:vb611582958 _:vb611582959 _:vb611582952 _:vb611582953 _:vb611582954 _:vb611582955 _:vb611582932 _:vb611582933 _:vb611582934 _:vb611582935 _:vb611582928 _:vb611582929 _:vb611582930 _:vb611582931 _:vb611582940 _:vb611582941 _:vb611582942 _:vb611582943 _:vb611582936 _:vb611582937 _:vb611582938 _:vb611582939 _:vb611582916 _:vb611582917 _:vb611582918 _:vb611582919 _:vb611582912 _:vb611582913 _:vb611582914 _:vb611582915 _:vb611582924 _:vb611582925 _:vb611582926 _:vb611582927 _:vb611582920 _:vb611582921 _:vb611582922 _:vb611582923 _:vb611582900 _:vb611582901 _:vb611582902 _:vb611582903 _:vb611582896 _:vb611582897 _:vb611582898 _:vb611582899 _:vb611582908 _:vb611582909 _:vb611582910 _:vb611582911 _:vb611582904 _:vb611582905 _:vb611582906 _:vb611582907 _:vb611582884 _:vb611582885 _:vb611582886 _:vb611582887 _:vb611582880 _:vb611582881 _:vb611582882 _:vb611582883 _:vb611582892 _:vb611582893 _:vb611582894 _:vb611582895 _:vb611582888 _:vb611582889 _:vb611582890 _:vb611582891 _:vb611582868 _:vb611582869 _:vb611582870 _:vb611582871 _:vb611582864 _:vb611582865 _:vb611582866 _:vb611582867 _:vb611582876 _:vb611582877 _:vb611582878 _:vb611582879 _:vb611582872 _:vb611582873 _:vb611582874 _:vb611582875 _:vb611582852 _:vb611582853 _:vb611582854 _:vb611582855 _:vb611582848 _:vb611582849 _:vb611582850 _:vb611582851 _:vb611582860 _:vb611582861 _:vb611582862 _:vb611582863 _:vb611582856 _:vb611582857 _:vb611582858 _:vb611582859 _:vb611582836 _:vb611582837 _:vb611582838 _:vb611582839 _:vb611582832 _:vb611582833 _:vb611582834 _:vb611582835 _:vb611582844 _:vb611582845 _:vb611582846 _:vb611582847 _:vb611582840 _:vb611582841 _:vb611582842 _:vb611582843 _:vb611582820 _:vb611582821 _:vb611582822 _:vb611582823 _:vb611582816 _:vb611582817 _:vb611582818 _:vb611582819 _:vb611582828 _:vb611582829 _:vb611582830 _:vb611582831 _:vb611582824 _:vb611582825 _:vb611582826 _:vb611582827 _:vb611582804 _:vb611582805 _:vb611582806 _:vb611582807 _:vb611582800 _:vb611582801 _:vb611582802 _:vb611582803 _:vb611582812 _:vb611582813 _:vb611582814 _:vb611582815 _:vb611582808 _:vb611582809 _:vb611582810 _:vb611582811 _:vb611582788 _:vb611582789 _:vb611582790 _:vb611582791 _:vb611582784 _:vb611582785 _:vb611582786 _:vb611582787 _:vb611582796 _:vb611582797 _:vb611582798 _:vb611582799 _:vb611582792 _:vb611582793 _:vb611582794 _:vb611582795 _:vb611582772 _:vb611582773 _:vb611582774 _:vb611582775 _:vb611582768 _:vb611582769 _:vb611582770 _:vb611582771 _:vb611582780 _:vb611582781 _:vb611582782 _:vb611582783 _:vb611582776 _:vb611582777 _:vb611582778 _:vb611582779 _:vb611582756 _:vb611582757 _:vb611582758 _:vb611582759 _:vb611582752 _:vb611582753 _:vb611582754 _:vb611582755 _:vb611582764 _:vb611582765 _:vb611582766 _:vb611582767 _:vb611582760 _:vb611582761 _:vb611582762 _:vb611582763 _:vb611582740 _:vb611582741 _:vb611582742 _:vb611582743 _:vb611582736 _:vb611582737 _:vb611582738 _:vb611582739 _:vb611582748 _:vb611582749 _:vb611582750 _:vb611582751 _:vb611582744 _:vb611582745 _:vb611582746 _:vb611582747 _:vb611582724 _:vb611582725 _:vb611582726 _:vb611582727 _:vb611582720 _:vb611582721 _:vb611582722 _:vb611582723 _:vb611582732 _:vb611582733 _:vb611582734 _:vb611582735 _:vb611582728 _:vb611582729 _:vb611582730 _:vb611582731 _:vb611583108 _:vb611583109 _:vb611583110 _:vb611583111 _:vb611583104 _:vb611583105 _:vb611583106 _:vb611583107 _:vb611583116 _:vb611583117 _:vb611583118 _:vb611583119 _:vb611583112 _:vb611583113 _:vb611583114 _:vb611583115 _:vb611583092 _:vb611583093 _:vb611583094 _:vb611583095 _:vb611583088 _:vb611583089 _:vb611583090 _:vb611583091 _:vb611583100 _:vb611583101 _:vb611583102 _:vb611583103 _:vb611583096 _:vb611583097 _:vb611583098 _:vb611583099 _:vb611583076 _:vb611583077 _:vb611583078 _:vb611583079 _:vb611583072 _:vb611583073 _:vb611583074 _:vb611583075 _:vb611583084 _:vb611583085 _:vb611583086 _:vb611583087 _:vb611583080 _:vb611583081 _:vb611583082 _:vb611583083 _:vb611583060 _:vb611583061 _:vb611583062 _:vb611583063 _:vb611583056 _:vb611583057 _:vb611583058 _:vb611583059 _:vb611583068 _:vb611583069 _:vb611583070 _:vb611583071 _:vb611583064 _:vb611583065 _:vb611583066 _:vb611583067 _:vb611583044 _:vb611583045 _:vb611583046 _:vb611583047 _:vb611583040 _:vb611583041 _:vb611583042 _:vb611583043 _:vb611583052 _:vb611583053 _:vb611583054 _:vb611583055 _:vb611583048 _:vb611583049 _:vb611583050 _:vb611583051 _:vb611583028 _:vb611583029 _:vb611583030 _:vb611583031 _:vb611583024 _:vb611583025 _:vb611583026 _:vb611583027 _:vb611583036 _:vb611583037 _:vb611583038 _:vb611583039 _:vb611583032 _:vb611583033 _:vb611583034 _:vb611583035 _:vb611583012 _:vb611583013 _:vb611583014 _:vb611583015 _:vb611583008 _:vb611583009 _:vb611583010 _:vb611583011 _:vb611583020 _:vb611583021 _:vb611583022 _:vb611583023 _:vb611583016 _:vb611583017 _:vb611583018 _:vb611583019 _:vb611582996 _:vb611582997 _:vb611582998 _:vb611582999 _:vb611582992 _:vb611582993 _:vb611582994 _:vb611582995 _:vb611583004 _:vb611583005 _:vb611583006 _:vb611583007 _:vb611583000 _:vb611583001 _:vb611583002 _:vb611583003 _:vb611582980 _:vb611582981 _:vb611582982 _:vb611582983 _:vb611582976 _:vb611582977 _:vb611582978 _:vb611582979 _:vb611582988 _:vb611582989 _:vb611582990 _:vb611582991 _:vb611582984 _:vb611582985 _:vb611582986 _:vb611582987
n2:pmcid
PMC0
bibo:doi
10.1007%2Fs00401-016-1606-5
n4:contains
_:vb54525980 _:vb54526054 _:vb54526071 _:vb54525863 _:vb54525868 _:vb54525826 _:vb54525850 _:vb54525986
Subject Item
_:vb54525826
rdf:type
n4:Section
dc:title
introduction
n4:contains
_:vb54525836 _:vb54525837 _:vb54525838 _:vb54525839 _:vb54525832 _:vb54525833 _:vb54525834 _:vb54525835 _:vb54525828 _:vb54525829 _:vb54525830 _:vb54525831 _:vb54525827 _:vb54525848 _:vb54525849 _:vb54525844 _:vb54525845 _:vb54525846 _:vb54525847 _:vb54525840 _:vb54525841 _:vb54525842 _:vb54525843
Subject Item
_:vb54525827
rdf:type
n2:Context
rdf:value
immune privilege for the CNS arose from experiments by Shirai nearly 100 years ago in which foreign homologous tissues were grafted to the brain and survived for prolonged periods; the concept was further emphasised by Medawar in 1948 [>>29<<, 86]. Nevertheless, immunological reactions do occur within the CNS particularly in association with infections by microorganisms and with diseases, such as multiple sclerosis (MS), that have an autoimmune component.
n2:mentions
n3:16972896
Subject Item
_:vb54525828
rdf:type
n2:Context
rdf:value
privilege for the CNS arose from experiments by Shirai nearly 100 years ago in which foreign homologous tissues were grafted to the brain and survived for prolonged periods; the concept was further emphasised by Medawar in 1948 [29, >>86<<]. Nevertheless, immunological reactions do occur within the CNS particularly in association with infections by microorganisms and with diseases, such as multiple sclerosis (MS), that have an autoimmune component.
n2:mentions
n3:18865105
Subject Item
_:vb54525829
rdf:type
n2:Context
rdf:value
As a sequel to the grafting experiments, it was shown that if the same allografts were subsequently grafted on to the skin, allografts in the brain were rapidly rejected [>>29<<, 86]. It appears, therefore, that immunization in peripheral tissues precipitates immunological rejection of foreign tissue in the CNS. The description of immune privileged sites as those in which: “grafts transplanted to them are in some
n2:mentions
n3:16972896
Subject Item
_:vb54525830
rdf:type
n2:Context
rdf:value
As a sequel to the grafting experiments, it was shown that if the same allografts were subsequently grafted on to the skin, allografts in the brain were rapidly rejected [29, >>86<<]. It appears, therefore, that immunization in peripheral tissues precipitates immunological rejection of foreign tissue in the CNS. The description of immune privileged sites as those in which: “grafts transplanted to them are in some way
n2:mentions
n3:18865105
Subject Item
_:vb54525831
rdf:type
n2:Context
rdf:value
of immune privileged sites as those in which: “grafts transplanted to them are in some way partially or fully exempted from the normal rigours imposed by their histocompatibility status” is a definition of a state of relative tolerance [>>12<<, 45]. One further point that has been emphasised is that immune privilege does not apply to the meninges and CSF spaces [45].
n2:mentions
n3:345773
Subject Item
_:vb54525832
rdf:type
n2:Context
rdf:value
privileged sites as those in which: “grafts transplanted to them are in some way partially or fully exempted from the normal rigours imposed by their histocompatibility status” is a definition of a state of relative tolerance [12, >>45<<]. One further point that has been emphasised is that immune privilege does not apply to the meninges and CSF spaces [45].
n2:mentions
n3:17129764
Subject Item
_:vb54525833
rdf:type
n2:Context
rdf:value
One further point that has been emphasised is that immune privilege does not apply to the meninges and CSF spaces [>>45<<]. If foreign tissue grafted into the brain enters the ventricles, it is rejected [45, 85].
n2:mentions
n3:17129764
Subject Item
_:vb54525834
rdf:type
n2:Context
rdf:value
If foreign tissue grafted into the brain enters the ventricles, it is rejected [>>45<<, 85].
n2:mentions
n3:17129764
Subject Item
_:vb54525835
rdf:type
n2:Context
rdf:value
If foreign tissue grafted into the brain enters the ventricles, it is rejected [45, >>85<<].
n2:mentions
n3:3796814
Subject Item
_:vb54525836
rdf:type
n2:Context
rdf:value
Expression of MHC class I and II molecules on microglial cells has been shown to be suppressed by the electrical activity of CNS neurons [>>94<<]. Disturbance of this activity during neurological disorders combined with cytokine activation of microglial cells leads to expression of MHC class I and class II molecules on their surfaces and subsequent presentation of antigen to
n2:mentions
n3:11596127
Subject Item
_:vb54525837
rdf:type
n2:Context
rdf:value
activity during neurological disorders combined with cytokine activation of microglial cells leads to expression of MHC class I and class II molecules on their surfaces and subsequent presentation of antigen to receptive T lymphocytes [>>13<<, 70, 80]. The adaptive response depends upon the presentation of antigen to lymphocytes by antigen-presenting cells (APC).
n2:mentions
n3:19829296
Subject Item
_:vb54525838
rdf:type
n2:Context
rdf:value
during neurological disorders combined with cytokine activation of microglial cells leads to expression of MHC class I and class II molecules on their surfaces and subsequent presentation of antigen to receptive T lymphocytes [13, >>70<<, 80]. The adaptive response depends upon the presentation of antigen to lymphocytes by antigen-presenting cells (APC).
n2:mentions
n3:18496841
Subject Item
_:vb54525839
rdf:type
n2:Context
rdf:value
during neurological disorders combined with cytokine activation of microglial cells leads to expression of MHC class I and class II molecules on their surfaces and subsequent presentation of antigen to receptive T lymphocytes [13, 70, >>80<<]. The adaptive response depends upon the presentation of antigen to lymphocytes by antigen-presenting cells (APC).
n2:mentions
n3:23624600
Subject Item
_:vb54525840
rdf:type
n2:Context
rdf:value
CSF drains from the subarachnoid space into lymphatic vessels in the nasal mucosa, in the dura mater, and into lymphatics associated with the sheaths of cranial and spinal nerve roots [>>11<<, 33, 69, 81].
n2:mentions
n3:26077718
Subject Item
_:vb54525841
rdf:type
n2:Context
rdf:value
CSF drains from the subarachnoid space into lymphatic vessels in the nasal mucosa, in the dura mater, and into lymphatics associated with the sheaths of cranial and spinal nerve roots [11, >>33<<, 69, 81]. The nasal and dural routes appear to allow the traffic of APC to lymph nodes [66, 81]; CSF compartments, (the ventricles and subarachnoid space), do not exhibit the same immune privilege as the parenchyma of the CNS. In contrast
n2:mentions
n3:1341962
Subject Item
_:vb54525842
rdf:type
n2:Context
rdf:value
CSF drains from the subarachnoid space into lymphatic vessels in the nasal mucosa, in the dura mater, and into lymphatics associated with the sheaths of cranial and spinal nerve roots [11, 33, >>69<<, 81]. The nasal and dural routes appear to allow the traffic of APC to lymph nodes [66, 81]; CSF compartments, (the ventricles and subarachnoid space), do not exhibit the same immune privilege as the parenchyma of the CNS. In contrast to
n2:mentions
n3:7510047
Subject Item
_:vb54525843
rdf:type
n2:Context
rdf:value
CSF drains from the subarachnoid space into lymphatic vessels in the nasal mucosa, in the dura mater, and into lymphatics associated with the sheaths of cranial and spinal nerve roots [11, 33, 69, >>81<<]. The nasal and dural routes appear to allow the traffic of APC to lymph nodes [66, 81]; CSF compartments, (the ventricles and subarachnoid space), do not exhibit the same immune privilege as the parenchyma of the CNS. In contrast to CSF,
n2:mentions
n3:26030524
Subject Item
_:vb54525844
rdf:type
n2:Context
rdf:value
The nasal and dural routes appear to allow the traffic of APC to lymph nodes [>>66<<, 81]; CSF compartments, (the ventricles and subarachnoid space), do not exhibit the same immune privilege as the parenchyma of the CNS.
n2:mentions
n3:22291210
Subject Item
_:vb54525845
rdf:type
n2:Context
rdf:value
The nasal and dural routes appear to allow the traffic of APC to lymph nodes [66, >>81<<]; CSF compartments, (the ventricles and subarachnoid space), do not exhibit the same immune privilege as the parenchyma of the CNS.
n2:mentions
n3:26030524
Subject Item
_:vb54525846
rdf:type
n2:Context
rdf:value
In contrast to CSF, ISF drains from the brain parenchyma to cervical lymph nodes along very narrow, restricted pathways that comprise 100–150 nm-thick basement membranes in the walls of cerebral capillaries, arterioles, and arteries [>>24<<, 26] (Fig. 1).
n2:mentions
n3:18208483
Subject Item
_:vb54525847
rdf:type
n2:Context
rdf:value
contrast to CSF, ISF drains from the brain parenchyma to cervical lymph nodes along very narrow, restricted pathways that comprise 100–150 nm-thick basement membranes in the walls of cerebral capillaries, arterioles, and arteries [24, >>26<<] (Fig. 1). Such intramural perivascular basement membrane pathways are not large enough to allow the traffic of APC to regional lymph nodes and this may be a key factor in inducing immune privilege in the parenchyma of the CNS [24, 26].
n2:mentions
n3:24145049
Subject Item
_:vb54525848
rdf:type
n2:Context
rdf:value
Such intramural perivascular basement membrane pathways are not large enough to allow the traffic of APC to regional lymph nodes and this may be a key factor in inducing immune privilege in the parenchyma of the CNS [>>24<<, 26].Fig.
n2:mentions
n3:18208483
Subject Item
_:vb54525849
rdf:type
n2:Context
rdf:value
Such intramural perivascular basement membrane pathways are not large enough to allow the traffic of APC to regional lymph nodes and this may be a key factor in inducing immune privilege in the parenchyma of the CNS [24, >>26<<].Fig.
n2:mentions
n3:24145049
Subject Item
_:vb54525850
rdf:type
n4:Section
dc:title
tolerance
n4:contains
_:vb54525852 _:vb54525853 _:vb54525854 _:vb54525855 _:vb54525851 _:vb54525860 _:vb54525861 _:vb54525862 _:vb54525856 _:vb54525857 _:vb54525858 _:vb54525859
Subject Item
_:vb54525851
rdf:type
n2:Context
rdf:value
contributions of cervical lymph nodes to detrimental immunity in multiple sclerosis (MS) and EAE may seem rather obvious, it is important to point out that the cervical lymph nodes clearly can also mediate the induction of tolerance [>>88<<, 143]. For example, the injection of myelin basic protein into the CSF induces tolerance and prevents the subsequent induction of EAE [49].
n2:mentions
n3:24565479
Subject Item
_:vb54525852
rdf:type
n2:Context
rdf:value
of cervical lymph nodes to detrimental immunity in multiple sclerosis (MS) and EAE may seem rather obvious, it is important to point out that the cervical lymph nodes clearly can also mediate the induction of tolerance [88, >>143<<]. For example, the injection of myelin basic protein into the CSF induces tolerance and prevents the subsequent induction of EAE [49].
n2:mentions
n3:9973470
Subject Item
_:vb54525853
rdf:type
n2:Context
rdf:value
For example, the injection of myelin basic protein into the CSF induces tolerance and prevents the subsequent induction of EAE [>>49<<]. Intranasal administration of antigen also drives tolerance through superficial cervical and internal jugular lymph nodes [143].
n2:mentions
n3:1720138
Subject Item
_:vb54525854
rdf:type
n2:Context
rdf:value
Intranasal administration of antigen also drives tolerance through superficial cervical and internal jugular lymph nodes [>>143<<].
n2:mentions
n3:9973470
Subject Item
_:vb54525855
rdf:type
n2:Context
rdf:value
As reviewed by Card et al. [>>28<<], lymphatic endothelium can play active roles in regulating host immunity.
n2:mentions
n3:24590280
Subject Item
_:vb54525856
rdf:type
n2:Context
rdf:value
Recent studies claim that in experimental stroke, autoimmunity does develop after massive release of CNS antigens, [>>133<<]. This follows up on studies by the same group demonstrating brain antigens in cervical lymph nodes of patients with stroke; there is some correlation between antigen load, type, and clinical outcome [108].
n2:mentions
n3:25309322
Subject Item
_:vb54525857
rdf:type
n2:Context
rdf:value
This follows up on studies by the same group demonstrating brain antigens in cervical lymph nodes of patients with stroke; there is some correlation between antigen load, type, and clinical outcome [>>108<<]. Very little evidence of MS or encephalitis has emerged following
n2:mentions
n3:22287710
Subject Item
_:vb54525858
rdf:type
n2:Context
rdf:value
Very recently, in back-to-back studies, the next generation sequencing was used to assess B-cell receptor repertoire in MS in peripheral blood versus CSF [>>104<<] and in brain versus cervical lymph nodes [82, 128].
n2:mentions
n3:25100740
Subject Item
_:vb54525859
rdf:type
n2:Context
rdf:value
Very recently, in back-to-back studies, the next generation sequencing was used to assess B-cell receptor repertoire in MS in peripheral blood versus CSF [104] and in brain versus cervical lymph nodes [82, >>128<<]. Stern and colleagues [128] found B-cell populations with sequences closely resembling the germline, dubbed founder events, which were highly represented in both the CNS and cervical lymph nodes.
n2:mentions
n3:25100741
Subject Item
_:vb54525860
rdf:type
n2:Context
rdf:value
Stern and colleagues [>>128<<] found B-cell populations with sequences closely resembling the germline, dubbed founder events, which were highly represented in both the CNS and cervical lymph nodes.
n2:mentions
n3:25100741
Subject Item
_:vb54525861
rdf:type
n2:Context
rdf:value
First, in a transgenic spontaneous EAE model driven by CD4+ T cells against MOG92-106, in which germfree conditions abolish disease induction, the cervical lymph nodes feature an ongoing MOG-specific germinal centre reaction [>>18<<]. Second, work from Lloyd and Dennis Kasper on how polysaccharide A from Bacteroides fragilis protects against EAE demonstrates increased numbers of regulatory T cells in cervical lymph nodes [98]. These studies underscore the importance
n2:mentions
n3:22031325
Subject Item
_:vb54525862
rdf:type
n2:Context
rdf:value
Second, work from Lloyd and Dennis Kasper on how polysaccharide A from Bacteroides fragilis protects against EAE demonstrates increased numbers of regulatory T cells in cervical lymph nodes [>>98<<]. These studies underscore the importance of cervical lymph nodes for both T-cell and B-cell responses.
n2:mentions
n3:20817872
Subject Item
_:vb54525863
rdf:type
n4:Section
dc:title
lymphatic drainage of systemic organs other than the cns
n4:contains
_:vb54525864 _:vb54525865 _:vb54525866 _:vb54525867
Subject Item
_:vb54525864
rdf:type
n2:Context
rdf:value
the brain, spinal cord and parts of the eye, specialized lymphatic vessels begin as blind-ended capillaries and allow the free uptake of excess protein-rich ISF via discontinuous button-like junctions between lymphatic endothelial cells [>>6<<] (Fig. 2a). Once within the lymphatic vessels, tissue fluid is referred to as lymph.
n2:mentions
n3:22064427
Subject Item
_:vb54525865
rdf:type
n2:Context
rdf:value
DCs first crawl along the lymphatic endothelium using specific adhesive interactions, e.g., the cytokine CCL21, before they detach and are passively transported to the regional lymph nodes in the larger calibre lymphatic vessels [>>97<<, 115]. Once they have arrived in the lymph node, DCs activate antigen-specific T cells that in turn proliferate and reach the blood stream via the efferent lymphatic vessels. The activation of B cells is mediated by the binding of soluble
n2:mentions
n3:22855606
Subject Item
_:vb54525866
rdf:type
n2:Context
rdf:value
DCs first crawl along the lymphatic endothelium using specific adhesive interactions, e.g., the cytokine CCL21, before they detach and are passively transported to the regional lymph nodes in the larger calibre lymphatic vessels [97, >>115<<]. Once they have arrived in the lymph node, DCs activate antigen-specific T cells that in turn proliferate and reach the blood stream via the efferent lymphatic vessels.
n2:mentions
n3:26876174
Subject Item
_:vb54525867
rdf:type
n2:Context
rdf:value
cues from food (e.g., vitamin A) and sunlight (UV induced vitamin D3) are metabolized by DCs which allows them to imprint tissue-specific homing patterns in activated effector lymphocytes during the process of antigen presentation [>>125<<]. Effector T cells produced in lymph nodes that drain the skin express the chemokine receptors CCR4 and CCR10 and the cutaneous lymphocyte antigen, while effector T cells produced in lymph nodes that drain the gut express CCR9 and α4β7
n2:mentions
n3:18711435
Subject Item
_:vb54525868
rdf:type
n4:Section
dc:title
lymphatic drainage of the cns
n4:contains
_:vb54525908 _:vb54525909 _:vb54525910 _:vb54525911 _:vb54525904 _:vb54525905 _:vb54525906 _:vb54525907 _:vb54525916 _:vb54525917 _:vb54525918 _:vb54525919 _:vb54525912 _:vb54525913 _:vb54525914 _:vb54525915 _:vb54525892 _:vb54525893 _:vb54525894 _:vb54525895 _:vb54525888 _:vb54525889 _:vb54525890 _:vb54525891 _:vb54525900 _:vb54525901 _:vb54525902 _:vb54525903 _:vb54525896 _:vb54525897 _:vb54525898 _:vb54525899 _:vb54525940 _:vb54525941 _:vb54525942 _:vb54525943 _:vb54525936 _:vb54525937 _:vb54525938 _:vb54525939 _:vb54525948 _:vb54525949 _:vb54525950 _:vb54525951 _:vb54525944 _:vb54525945 _:vb54525946 _:vb54525947 _:vb54525924 _:vb54525925 _:vb54525926 _:vb54525927 _:vb54525920 _:vb54525921 _:vb54525922 _:vb54525923 _:vb54525932 _:vb54525933 _:vb54525934 _:vb54525935 _:vb54525928 _:vb54525929 _:vb54525930 _:vb54525931 _:vb54525876 _:vb54525877 _:vb54525878 _:vb54525879 _:vb54525872 _:vb54525873 _:vb54525874 _:vb54525875 _:vb54525884 _:vb54525885 _:vb54525886 _:vb54525887 _:vb54525880 _:vb54525881 _:vb54525882 _:vb54525883 _:vb54525869 _:vb54525870 _:vb54525871 _:vb54525972 _:vb54525973 _:vb54525974 _:vb54525975 _:vb54525968 _:vb54525969 _:vb54525970 _:vb54525971 _:vb54525976 _:vb54525977 _:vb54525978 _:vb54525979 _:vb54525956 _:vb54525957 _:vb54525958 _:vb54525959 _:vb54525952 _:vb54525953 _:vb54525954 _:vb54525955 _:vb54525964 _:vb54525965 _:vb54525966 _:vb54525967 _:vb54525960 _:vb54525961 _:vb54525962 _:vb54525963
Subject Item
_:vb54525869
rdf:type
n2:Context
rdf:value
Of the two extracellular tissue fluids associated with the CNS, CSF is mainly located in the ventricles and subarachnoid spaces and has a total volume in humans of 140 mL [>>19<<]. The other fluid is ISF in the extracellular spaces of the brain and spinal cord parenchyma and amounts to 280 mL in humans [19].
n2:mentions
n3:11524285
Subject Item
_:vb54525870
rdf:type
n2:Context
rdf:value
The other fluid is ISF in the extracellular spaces of the brain and spinal cord parenchyma and amounts to 280 mL in humans [>>19<<]. Both CSF and ISF drain to lymph nodes and are involved in immunological reactions within the CNS [34, 74, 106].
n2:mentions
n3:11524285
Subject Item
_:vb54525871
rdf:type
n2:Context
rdf:value
Both CSF and ISF drain to lymph nodes and are involved in immunological reactions within the CNS [>>34<<, 74, 106].
n2:mentions
n3:1463583
Subject Item
_:vb54525872
rdf:type
n2:Context
rdf:value
Both CSF and ISF drain to lymph nodes and are involved in immunological reactions within the CNS [34, >>74<<, 106].
n2:mentions
n3:23695293
Subject Item
_:vb54525873
rdf:type
n2:Context
rdf:value
Both CSF and ISF drain to lymph nodes and are involved in immunological reactions within the CNS [34, 74, >>106<<].
n2:mentions
n3:9306968
Subject Item
_:vb54525874
rdf:type
n2:Context
rdf:value
A further proportion of CSF drains to regional lymph nodes via nasal lymphatics and dural lymphatics and via lymphatic vessels associated with cranial and spinal nerve roots [>>11<<, 33, 65, 69, 81] (Fig.
n2:mentions
n3:26077718
Subject Item
_:vb54525875
rdf:type
n2:Context
rdf:value
A further proportion of CSF drains to regional lymph nodes via nasal lymphatics and dural lymphatics and via lymphatic vessels associated with cranial and spinal nerve roots [11, >>33<<, 65, 69, 81] (Fig.
n2:mentions
n3:1341962
Subject Item
_:vb54525876
rdf:type
n2:Context
rdf:value
A further proportion of CSF drains to regional lymph nodes via nasal lymphatics and dural lymphatics and via lymphatic vessels associated with cranial and spinal nerve roots [11, 33, 65, >>69<<, 81] (Fig.
n2:mentions
n3:7510047
Subject Item
_:vb54525877
rdf:type
n2:Context
rdf:value
A further proportion of CSF drains to regional lymph nodes via nasal lymphatics and dural lymphatics and via lymphatic vessels associated with cranial and spinal nerve roots [11, 33, 65, 69, >>81<<] (Fig. 1). It is estimated that at least 50 % of CSF drains into lymphatics in some mammals, [33] but the proportion in humans is still unknown [65].
n2:mentions
n3:26030524
Subject Item
_:vb54525878
rdf:type
n2:Context
rdf:value
It is estimated that at least 50 % of CSF drains into lymphatics in some mammals, [>>33<<] but the proportion in humans is still unknown [65].
n2:mentions
n3:1341962
Subject Item
_:vb54525879
rdf:type
n2:Context
rdf:value
This pathway was demonstrated in humans in 1912 [148] and has more recently been confirmed in more detail in rats and other mammals, including humans [65, >>69<<]. CSF from the spinal subarachnoid space drains to lumbar lymph nodes [69].
n2:mentions
n3:7510047
Subject Item
_:vb54525880
rdf:type
n2:Context
rdf:value
This pathway was demonstrated in humans in 1912 [148] and has more recently been confirmed in more detail in rats and other mammals, including humans [65, 69]. CSF from the spinal subarachnoid space drains to lumbar lymph nodes [>>69<<].
n2:mentions
n3:7510047
Subject Item
_:vb54525881
rdf:type
n2:Context
rdf:value
Two recent articles elegantly demonstrated functional lymphatic vessels in the dura mater of the mouse situated bilaterally along the superior sagittal sinus and draining through the cribriform plate into the nasal mucosa [>>11<<, 81]. Lymph vessels of the dura mater were probably described first by Mascagni in 1787 in his study “De lymphaticis profundis capitis et colli” [21], and since then, functional drainage by this route has been demonstrated by Schwalbe et
n2:mentions
n3:26077718
Subject Item
_:vb54525882
rdf:type
n2:Context
rdf:value
Two recent articles elegantly demonstrated functional lymphatic vessels in the dura mater of the mouse situated bilaterally along the superior sagittal sinus and draining through the cribriform plate into the nasal mucosa [11, >>81<<]. Lymph vessels of the dura mater were probably described first by Mascagni in 1787 in his study “De lymphaticis profundis capitis et colli” [21], and since then, functional drainage by this route has been demonstrated by Schwalbe et al.
n2:mentions
n3:26030524
Subject Item
_:vb54525883
rdf:type
n2:Context
rdf:value
Lymph vessels of the dura mater were probably described first by Mascagni in 1787 in his study “De lymphaticis profundis capitis et colli” [>>21<<], and since then, functional drainage by this route has been demonstrated by Schwalbe et al. [121], Andres et al. [9], Cserr and Knopf [34], Kida et al. [69], and more recently by Aspelund et al. [11] and by Louveau et al. [81].
n2:mentions
n3:26383824
Subject Item
_:vb54525884
rdf:type
n2:Context
rdf:value
dura mater were probably described first by Mascagni in 1787 in his study “De lymphaticis profundis capitis et colli” [21], and since then, functional drainage by this route has been demonstrated by Schwalbe et al. [121], Andres et al. [>>9<<], Cserr and Knopf [34], Kida et al. [69], and more recently by Aspelund et al. [11] and by Louveau et al. [81].
n2:mentions
n3:3826655
Subject Item
_:vb54525885
rdf:type
n2:Context
rdf:value
described first by Mascagni in 1787 in his study “De lymphaticis profundis capitis et colli” [21], and since then, functional drainage by this route has been demonstrated by Schwalbe et al. [121], Andres et al. [9], Cserr and Knopf [>>34<<], Kida et al. [69], and more recently by Aspelund et al. [11] and by Louveau et al. [81].
n2:mentions
n3:1463583
Subject Item
_:vb54525886
rdf:type
n2:Context
rdf:value
by Mascagni in 1787 in his study “De lymphaticis profundis capitis et colli” [21], and since then, functional drainage by this route has been demonstrated by Schwalbe et al. [121], Andres et al. [9], Cserr and Knopf [34], Kida et al. [>>69<<], and more recently by Aspelund et al. [11] and by Louveau et al. [81].
n2:mentions
n3:7510047
Subject Item
_:vb54525887
rdf:type
n2:Context
rdf:value
profundis capitis et colli” [21], and since then, functional drainage by this route has been demonstrated by Schwalbe et al. [121], Andres et al. [9], Cserr and Knopf [34], Kida et al. [69], and more recently by Aspelund et al. [>>11<<] and by Louveau et al. [81].
n2:mentions
n3:26077718
Subject Item
_:vb54525888
rdf:type
n2:Context
rdf:value
colli” [21], and since then, functional drainage by this route has been demonstrated by Schwalbe et al. [121], Andres et al. [9], Cserr and Knopf [34], Kida et al. [69], and more recently by Aspelund et al. [11] and by Louveau et al. [>>81<<]. Although it has been suggested that lymphatic vessels in the dura drain fluid, solutes, and cells from the brain parenchyma, no such drainage has been demonstrated and the anatomical pathways for such drainage have not been demonstrated.
n2:mentions
n3:26030524
Subject Item
_:vb54525889
rdf:type
n2:Context
rdf:value
The capacity of the lymphatic drainage pathways for the CSF is reflected in experiments using particulate matter, such as Indian ink and Microfil [65, >>69<<]. Several studies have also demonstrated efflux of T cells and APC from the CSF into deep cervical lymph nodes [47, 50, 51, 66, 101].
n2:mentions
n3:7510047
Subject Item
_:vb54525890
rdf:type
n2:Context
rdf:value
Several studies have also demonstrated efflux of T cells and APC from the CSF into deep cervical lymph nodes [>>47<<, 50, 51, 66, 101].
n2:mentions
n3:16885505
Subject Item
_:vb54525891
rdf:type
n2:Context
rdf:value
Several studies have also demonstrated efflux of T cells and APC from the CSF into deep cervical lymph nodes [47, >>50<<, 51, 66, 101].
n2:mentions
n3:16204309
Subject Item
_:vb54525892
rdf:type
n2:Context
rdf:value
Several studies have also demonstrated efflux of T cells and APC from the CSF into deep cervical lymph nodes [47, 50, >>51<<, 66, 101].
n2:mentions
n3:18830405
Subject Item
_:vb54525893
rdf:type
n2:Context
rdf:value
Several studies have also demonstrated efflux of T cells and APC from the CSF into deep cervical lymph nodes [47, 50, 51, >>66<<, 101]. Moreover, myelin and axonal epitopes have been found in deep cervical lymph nodes after axonal injury and (autoimmune) demyelination [36, 40, 79, 93]. Although it can be emphasised that APC may drain with CSF to lymph nodes by
n2:mentions
n3:22291210
Subject Item
_:vb54525894
rdf:type
n2:Context
rdf:value
Several studies have also demonstrated efflux of T cells and APC from the CSF into deep cervical lymph nodes [47, 50, 51, 66, >>101<<]. Moreover, myelin and axonal epitopes have been found in deep cervical lymph nodes after axonal injury and (autoimmune) demyelination [36, 40, 79, 93]. Although it can be emphasised that APC may drain with CSF to lymph nodes by various
n2:mentions
n3:760365
Subject Item
_:vb54525895
rdf:type
n2:Context
rdf:value
Moreover, myelin and axonal epitopes have been found in deep cervical lymph nodes after axonal injury and (autoimmune) demyelination [>>36<<, 40, 79, 93].
n2:mentions
n3:12421916
Subject Item
_:vb54525896
rdf:type
n2:Context
rdf:value
Moreover, myelin and axonal epitopes have been found in deep cervical lymph nodes after axonal injury and (autoimmune) demyelination [36, >>40<<, 79, 93]. Although it can be emphasised that APC may drain with CSF to lymph nodes by various routes, the migration of APC from brain parenchyma with ISF along narrow intramural periarterial pathways is highly unlikely (see section on
n2:mentions
n3:15748959
Subject Item
_:vb54525897
rdf:type
n2:Context
rdf:value
Moreover, myelin and axonal epitopes have been found in deep cervical lymph nodes after axonal injury and (autoimmune) demyelination [36, 40, >>79<<, 93]. Although it can be emphasised that APC may drain with CSF to lymph nodes by various routes, the migration of APC from brain parenchyma with ISF along narrow intramural periarterial pathways is highly unlikely (see section on
n2:mentions
n3:22366759
Subject Item
_:vb54525898
rdf:type
n2:Context
rdf:value
Moreover, myelin and axonal epitopes have been found in deep cervical lymph nodes after axonal injury and (autoimmune) demyelination [36, 40, 79, >>93<<]. Although it can be emphasised that APC may drain with CSF to lymph nodes by various routes, the migration of APC from brain parenchyma with ISF along narrow intramural periarterial pathways is highly unlikely (see section on “Intramural
n2:mentions
n3:17091291
Subject Item
_:vb54525899
rdf:type
n2:Context
rdf:value
the extracellular spaces (ECS) and then rapidly enter the basement membranes of cerebral capillaries and drain directly via basement membranes in the tunica media of arterioles and arteries out of the brain to cervical lymph nodes [>>24<<, 26, 33] (Figs. 1, 2c, 3, 4).
n2:mentions
n3:18208483
Subject Item
_:vb54525900
rdf:type
n2:Context
rdf:value
the extracellular spaces (ECS) and then rapidly enter the basement membranes of cerebral capillaries and drain directly via basement membranes in the tunica media of arterioles and arteries out of the brain to cervical lymph nodes [24, >>26<<, 33] (Figs. 1, 2c, 3, 4).
n2:mentions
n3:24145049
Subject Item
_:vb54525901
rdf:type
n2:Context
rdf:value
extracellular spaces (ECS) and then rapidly enter the basement membranes of cerebral capillaries and drain directly via basement membranes in the tunica media of arterioles and arteries out of the brain to cervical lymph nodes [24, 26, >>33<<] (Figs. 1, 2c, 3, 4).
n2:mentions
n3:1341962
Subject Item
_:vb54525902
rdf:type
n2:Context
rdf:value
This intramural perivascular drainage route is outlined in the human brain by deposits of amyloid β (Aβ) in basement membranes in cerebral amyloid angiopathy (CAA) associated with age and with Alzheimer’s disease [>>25<<, 141]. Injection of larger volumes (2 μL) of tracer into the striatum of the mouse brain results in the passage of tracer into CSF in the ventricles [15].Fig.
n2:mentions
n3:23489283
Subject Item
_:vb54525903
rdf:type
n2:Context
rdf:value
This intramural perivascular drainage route is outlined in the human brain by deposits of amyloid β (Aβ) in basement membranes in cerebral amyloid angiopathy (CAA) associated with age and with Alzheimer’s disease [25, >>141<<]. Injection of larger volumes (2 μL) of tracer into the striatum of the mouse brain results in the passage of tracer into CSF in the ventricles [15].Fig.
n2:mentions
n3:9736023
Subject Item
_:vb54525904
rdf:type
n2:Context
rdf:value
Injection of larger volumes (2 μL) of tracer into the striatum of the mouse brain results in the passage of tracer into CSF in the ventricles [>>15<<].Fig.
n2:mentions
n3:26435380
Subject Item
_:vb54525905
rdf:type
n2:Context
rdf:value
10 % contribution to the total volume of ISF, but recently, it has been proposed that a large fraction of ISF is derived from the blood, passing through the capillary endothelium and driven by Na, K ATPase with water following passively [>>2<<]. In addition to water, ISF consists of tissue metabolites and secreted proteins.
n2:mentions
n3:15186921
Subject Item
_:vb54525906
rdf:type
n2:Context
rdf:value
The rate of bulk flow of ISF is estimated to be 0.1–0.3 µL min−1 g−1 in the rat brain [>>2<<]. Tracer experiments and mathematical models show that ISF is eliminated from the brain by bulk flow along white matter fibre tracts and along perivascular pathways [32, 119].
n2:mentions
n3:15186921
Subject Item
_:vb54525907
rdf:type
n2:Context
rdf:value
Tracer experiments and mathematical models show that ISF is eliminated from the brain by bulk flow along white matter fibre tracts and along perivascular pathways [>>32<<, 119].
n2:mentions
n3:7223889
Subject Item
_:vb54525908
rdf:type
n2:Context
rdf:value
Tracer experiments and mathematical models show that ISF is eliminated from the brain by bulk flow along white matter fibre tracts and along perivascular pathways [32, >>119<<].
n2:mentions
n3:16112683
Subject Item
_:vb54525909
rdf:type
n2:Context
rdf:value
Electron microscopy has shown that very narrow gaps separate the cells of the CNS, particularly in the grey matter [>>58<<, 91]. The gaps are interconnected and are filled with ISF; they represent the extracellular spaces (ECS) and are in direct continuity with the basement membranes of capillaries [89].
n2:mentions
n3:10994852
Subject Item
_:vb54525910
rdf:type
n2:Context
rdf:value
The gaps are interconnected and are filled with ISF; they represent the extracellular spaces (ECS) and are in direct continuity with the basement membranes of capillaries [>>89<<]. The most significant exchange between blood and CNS occurs at the capillary level. Cerebral capillary endothelial cells are connected by highly complex and continuous tight junctions and form the BBB. While crossing the BBB requires
n2:mentions
n3:25285078
Subject Item
_:vb54525911
rdf:type
n2:Context
rdf:value
The movement of water mixed with the movement of soluble metabolites results in the flow of ISF [>>2<<, 3]. ISF drains from the ECS of the CNS parenchyma by entering capillary basement membranes and then draining along the basement membranes of cerebral arteries by bulk flow, as indicated by physiological tracer experiments [24]. Bulk flow
n2:mentions
n3:15186921
Subject Item
_:vb54525912
rdf:type
n2:Context
rdf:value
The movement of water mixed with the movement of soluble metabolites results in the flow of ISF [2, >>3<<]. ISF drains from the ECS of the CNS parenchyma by entering capillary basement membranes and then draining along the basement membranes of cerebral arteries by bulk flow, as indicated by physiological tracer experiments [24]. Bulk flow of
n2:mentions
n3:23609350
Subject Item
_:vb54525913
rdf:type
n2:Context
rdf:value
ISF drains from the ECS of the CNS parenchyma by entering capillary basement membranes and then draining along the basement membranes of cerebral arteries by bulk flow, as indicated by physiological tracer experiments [>>24<<]. Bulk flow of ISF also occurs along the white matter fibre tracts [2]. Functionally, the ECS provides a pathway for the diffusion and exchange of ions and molecules between cells; the movement of ISF through the ECS surrounding the cells
n2:mentions
n3:18208483
Subject Item
_:vb54525914
rdf:type
n2:Context
rdf:value
Bulk flow of ISF also occurs along the white matter fibre tracts [>>2<<]. Functionally, the ECS provides a pathway for the diffusion and exchange of ions and molecules between cells; the movement of ISF through the ECS surrounding the cells of nervous system depends on diffusion [96, 130].
n2:mentions
n3:15186921
Subject Item
_:vb54525915
rdf:type
n2:Context
rdf:value
Functionally, the ECS provides a pathway for the diffusion and exchange of ions and molecules between cells; the movement of ISF through the ECS surrounding the cells of nervous system depends on diffusion [>>96<<, 130]. Diffusion through the ECS and bulk flow of ISF along perivascular drainage routes changes with age and in Alzheimer’s disease [54, 87].
n2:mentions
n3:23172993
Subject Item
_:vb54525916
rdf:type
n2:Context
rdf:value
Functionally, the ECS provides a pathway for the diffusion and exchange of ions and molecules between cells; the movement of ISF through the ECS surrounding the cells of nervous system depends on diffusion [96, >>130<<]. Diffusion through the ECS and bulk flow of ISF along perivascular drainage routes changes with age and in Alzheimer’s disease [54, 87].
n2:mentions
n3:18923183
Subject Item
_:vb54525917
rdf:type
n2:Context
rdf:value
Diffusion through the ECS and bulk flow of ISF along perivascular drainage routes changes with age and in Alzheimer’s disease [>>54<<, 87].
n2:mentions
n3:21259015
Subject Item
_:vb54525918
rdf:type
n2:Context
rdf:value
Diffusion through the ECS and bulk flow of ISF along perivascular drainage routes changes with age and in Alzheimer’s disease [54, >>87<<].
n2:mentions
n3:12658277
Subject Item
_:vb54525919
rdf:type
n2:Context
rdf:value
These authors injected minute amounts of radioiodinated serum albumin tracer into various regions of the rat brain and showed that the tracer drained to cervical lymph nodes along the walls of cerebral arteries [>>33<<]. The speed of drainage to lymph nodes was comparable to that of lymphatic drainage elsewhere in the body. Only 10–15 % of tracer injected into the caudate nucleus or internal capsule passed into the CSF, although this figure was higher
n2:mentions
n3:1341962
Subject Item
_:vb54525920
rdf:type
n2:Context
rdf:value
Only 10–15 % of tracer injected into the caudate nucleus or internal capsule passed into the CSF, although this figure was higher for tracer injected into the midbrain [>>131<<].
n2:mentions
n3:6742132
Subject Item
_:vb54525921
rdf:type
n2:Context
rdf:value
Individually, blood vessels in the mouse brain have a similar basic structure to those in the human brain [>>76<<].
n2:mentions
n3:7630927
Subject Item
_:vb54525922
rdf:type
n2:Context
rdf:value
3) [91, >>110<<]. While the junctions between adjacent endothelial cells form unique zonulae occludentes that inhibit paracellular diffusion of solutes, the high number of pericytes embedded in brain capillary basement membranes inhibits transcellular
n2:mentions
n3:12662319
Subject Item
_:vb54525923
rdf:type
n2:Context
rdf:value
zonulae occludentes that inhibit paracellular diffusion of solutes, the high number of pericytes embedded in brain capillary basement membranes inhibits transcellular vesicular activity and thus transcellular diffusion of solutes [>>17<<]. Fibrous astrocytes form end feet that completely surround the capillary surface:
n2:mentions
n3:24828040
Subject Item
_:vb54525924
rdf:type
n2:Context
rdf:value
Fibrous astrocytes form end feet that completely surround the capillary surface: 40–100 nm separate the astrocyte end feet from the endothelium and this space is occupied by basement membrane [>>38<<]. The layer of basement membrane produced by endothelial cells is distinct in its molecular structure from the basement membrane of the glia limitans produced by astrocytes, but the two basement membranes are fused. The capillary basement
n2:mentions
n3:21349152
Subject Item
_:vb54525925
rdf:type
n2:Context
rdf:value
The capillary basement membrane is in direct communication with the brain extracellular spaces and encircles pericytes [>>142<<] that are responsible for the regulation of capillary diameter and of cerebral blood flow in response to neural activity [16].
n2:mentions
n3:22030551
Subject Item
_:vb54525926
rdf:type
n2:Context
rdf:value
basement membrane is in direct communication with the brain extracellular spaces and encircles pericytes [142] that are responsible for the regulation of capillary diameter and of cerebral blood flow in response to neural activity [>>16<<].
n2:mentions
n3:21040844
Subject Item
_:vb54525927
rdf:type
n2:Context
rdf:value
artery on the surface of the brain (leptomeningeal artery) has an endothelium separated from layers of smooth muscle cells by basement membrane, an intimal layer of extracellular matrix, and, frequently, an internal elastic lamina [>>138<<, 144]. As an artery enters the cerebral cortex, it loses its internal elastic lamina and its tunica adventitia to become an arteriole (Fig.
n2:mentions
n3:19234858
Subject Item
_:vb54525928
rdf:type
n2:Context
rdf:value
adhesion of the vascular smooth muscle cells to their basement membranes is essential for maintaining the integrity of the arterial wall and for recognizing and integrating the high variety of signals that modulate the cell function [>>126<<].
n2:mentions
n3:15894540
Subject Item
_:vb54525929
rdf:type
n2:Context
rdf:value
of desmosomes and small nexus junctions, are reflected from the surface of the brain and spinal cord to coat arteries and veins in the SAS, thus separating CSF in the subarachnoid space from the CNS and perivascular compartments [>>95<<, 137] (Fig. 4). Furthermore, leptomeningeal cells form a perivascular sheath around arteries, as they enter the brain.
n2:mentions
n3:3392571
Subject Item
_:vb54525930
rdf:type
n2:Context
rdf:value
of desmosomes and small nexus junctions, are reflected from the surface of the brain and spinal cord to coat arteries and veins in the SAS, thus separating CSF in the subarachnoid space from the CNS and perivascular compartments [95, >>137<<] (Fig. 4). Furthermore, leptomeningeal cells form a perivascular sheath around arteries, as they enter the brain.
n2:mentions
n3:15943078
Subject Item
_:vb54525931
rdf:type
n2:Context
rdf:value
Venous perivascular spaces communicate with the subpial space, as veins tend to lack a complete perivascular coat of leptomeningeal cells [>>146<<].
n2:mentions
n3:2254158
Subject Item
_:vb54525932
rdf:type
n2:Context
rdf:value
The pia mater prevents particles and erythrocytes [>>60<<] and, probably, neurotransmitters [41] in the CSF from entering perivascular compartments of the brain, but the exact degree of selective permeability to solutes of the pia mater and underlying glia limitans is not known.
n2:mentions
n3:3734882
Subject Item
_:vb54525933
rdf:type
n2:Context
rdf:value
The pia mater prevents particles and erythrocytes [60] and, probably, neurotransmitters [>>41<<] in the CSF from entering perivascular compartments of the brain, but the exact degree of selective permeability to solutes of the pia mater and underlying glia limitans is not known.
n2:mentions
n3:1722030
Subject Item
_:vb54525934
rdf:type
n2:Context
rdf:value
There are regional differences in the structure of arteries within the brain as shown by the enlarged perivascular spaces that develop with age around arteries in the basal ganglia [>>109<<] and white matter [140]; the perivascular spaces are enclosed by two layers of leptomeninges in these regions of the brain [109].
n2:mentions
n3:9418990
Subject Item
_:vb54525935
rdf:type
n2:Context
rdf:value
There are regional differences in the structure of arteries within the brain as shown by the enlarged perivascular spaces that develop with age around arteries in the basal ganglia [109] and white matter [>>140<<]; the perivascular spaces are enclosed by two layers of leptomeninges in these regions of the brain [109].
n2:mentions
n3:25521178
Subject Item
_:vb54525936
rdf:type
n2:Context
rdf:value
as shown by the enlarged perivascular spaces that develop with age around arteries in the basal ganglia [109] and white matter [140]; the perivascular spaces are enclosed by two layers of leptomeninges in these regions of the brain [>>109<<]. Arteries in the cortex, on the other hand, have only one layer of encompassing leptomeningeal cells and do not have perivascular space [146] (Fig.
n2:mentions
n3:9418990
Subject Item
_:vb54525937
rdf:type
n2:Context
rdf:value
Arteries in the cortex, on the other hand, have only one layer of encompassing leptomeningeal cells and do not have perivascular space [>>146<<] (Fig. 4).
n2:mentions
n3:2254158
Subject Item
_:vb54525938
rdf:type
n2:Context
rdf:value
In the brain, basement membranes have been reported to be secreted by meningeal cells and contribute to the migration and final positioning of neurons and to the differentiation of the laminar cortical pattern during development [>>89<<]. Basement membranes are composed mainly of collagen type IV, laminins, nidogens, fibronectin, and heparan sulphate proteoglycans. The basement membrane is a dynamic complex, capable of remodelling itself. In vitro, type IV collagen,
n2:mentions
n3:25285078
Subject Item
_:vb54525939
rdf:type
n2:Context
rdf:value
In vitro, type IV collagen, laminin, and fibronectin are capable of assembly into a protein network resembling basement membranes and are interdependent in the formation of the basement membranes [>>145<<].
n2:mentions
n3:2180767
Subject Item
_:vb54525940
rdf:type
n2:Context
rdf:value
drainage of ISF and solutes from the brain parenchyma, minute quantities (0.5 μL) of fluorescent dextran 3KDa or ovalbumin 49KDa were injected into the grey matter of the caudate putamen in the centre of the mouse cerebral hemisphere [>>24<<]. By 5 min after injection, tracers had spread diffusely through the ECS, but tracer was also present in the walls of blood vessels.
n2:mentions
n3:18208483
Subject Item
_:vb54525941
rdf:type
n2:Context
rdf:value
that tracers were co-localized with laminin in the basement membranes of capillaries and in the basement membranes in the tunica media of arteries at time intervals of 5–15 min after intracerebral injections into the caudate putamen [>>24<<] (Fig. 3).
n2:mentions
n3:18208483
Subject Item
_:vb54525942
rdf:type
n2:Context
rdf:value
walls was very specific, as tracer was only in the basement membranes between the smooth muscle cells in the tunica media and not in the endothelial basement membranes or in the outer basement membrane encompassing the artery wall [>>24<<]. This defined the drainage route for ISF as an intramural perivascular pathway.
n2:mentions
n3:18208483
Subject Item
_:vb54525943
rdf:type
n2:Context
rdf:value
the artery wall [24]. This defined the drainage route for ISF as an intramural perivascular pathway. In the normal brain, there are no actual “perivascular spaces” around arteries, as they enter the cerebral cortex (Fig. 4) [>>90<<, 137, 146]. The drainage route for ISF and solutes is along pathways within the tunica media of arteries and not along perivascular spaces (Fig.
n2:mentions
n3:26975356
Subject Item
_:vb54525944
rdf:type
n2:Context
rdf:value
4) [90, >>137<<, 146]. The drainage route for ISF and solutes is along pathways within the tunica media of arteries and not along perivascular spaces (Fig.
n2:mentions
n3:15943078
Subject Item
_:vb54525945
rdf:type
n2:Context
rdf:value
4) [90, 137, >>146<<]. The drainage route for ISF and solutes is along pathways within the tunica media of arteries and not along perivascular spaces (Fig.
n2:mentions
n3:2254158
Subject Item
_:vb54525946
rdf:type
n2:Context
rdf:value
By 30 min after injection, the tracers had disappeared from the ECS of the brain and from the basement membranes in the walls of capillaries and arteries, but tracers remained in the perivascular macrophages [>>24<<]. By 24 h after injection, the route taken by the tracers on their passage out of the brain was outlined by perivascular macrophages containing tracer and situated adjacent to intracerebral arteries and around leptomeningeal arteries on
n2:mentions
n3:18208483
Subject Item
_:vb54525947
rdf:type
n2:Context
rdf:value
the route taken by the tracers on their passage out of the brain was outlined by perivascular macrophages containing tracer and situated adjacent to intracerebral arteries and around leptomeningeal arteries on the surface of the brain [>>24<<].
n2:mentions
n3:18208483
Subject Item
_:vb54525948
rdf:type
n2:Context
rdf:value
When particles in the range of 15 nm–1 μm are injected into grey matter in the brain, they do not drain along intramural basement membranes, but track along the outside of arteries and separate the glia limitans from the vessel walls [>>24<<, 147]. It was concluded from these studies that it was very unlikely that, due to their size, APC would be able to track along intramural arterial basement membranes from the brain to cervical lymph nodes [24].
n2:mentions
n3:18208483
Subject Item
_:vb54525949
rdf:type
n2:Context
rdf:value
particles in the range of 15 nm–1 μm are injected into grey matter in the brain, they do not drain along intramural basement membranes, but track along the outside of arteries and separate the glia limitans from the vessel walls [24, >>147<<]. It was concluded from these studies that it was very unlikely that, due to their size, APC would be able to track along intramural arterial basement membranes from the brain to cervical lymph nodes [24].
n2:mentions
n3:1373020
Subject Item
_:vb54525950
rdf:type
n2:Context
rdf:value
It was concluded from these studies that it was very unlikely that, due to their size, APC would be able to track along intramural arterial basement membranes from the brain to cervical lymph nodes [>>24<<].
n2:mentions
n3:18208483
Subject Item
_:vb54525951
rdf:type
n2:Context
rdf:value
serum albumin as a tracer suggest that once ISF and solutes have left the brain, they drain along the tunica media and the tunica adventitia of the major cerebral arteries, through the base of the skull to deep cervical lymph nodes [>>131<<] (Fig. 2c).
n2:mentions
n3:6742132
Subject Item
_:vb54525952
rdf:type
n2:Context
rdf:value
The high levels of radioactive tracer and Aβ in the walls of intracranial arteries and the very low levels of tracer and Aβ in the walls of the carotid artery in the neck [>>123<<, 131] together with the presence of lymph nodes within the carotid sheath just below the base of the skull in humans strongly suggest that ISF and solutes leave artery walls in the neck to drain to adjacent cervical lymph nodes [30].
n2:mentions
n3:7668828
Subject Item
_:vb54525953
rdf:type
n2:Context
rdf:value
The high levels of radioactive tracer and Aβ in the walls of intracranial arteries and the very low levels of tracer and Aβ in the walls of the carotid artery in the neck [123, >>131<<] together with the presence of lymph nodes within the carotid sheath just below the base of the skull in humans strongly suggest that ISF and solutes leave artery walls in the neck to drain to adjacent cervical lymph nodes [30].
n2:mentions
n3:6742132
Subject Item
_:vb54525954
rdf:type
n2:Context
rdf:value
[123, 131] together with the presence of lymph nodes within the carotid sheath just below the base of the skull in humans strongly suggest that ISF and solutes leave artery walls in the neck to drain to adjacent cervical lymph nodes [>>30<<]. Quantitative studies of lymphatic drainage from the brain have shown that the speed of drainage is comparable to lymphatic drainage from other organs [131].
n2:mentions
n3:19918869
Subject Item
_:vb54525955
rdf:type
n2:Context
rdf:value
Quantitative studies of lymphatic drainage from the brain have shown that the speed of drainage is comparable to lymphatic drainage from other organs [>>131<<]. The quantity and volume of fluorescent tracers injected to outline the basement membrane pathways for drainage of ISF from grey matter [24] are too small to be detected in the cervical lymph nodes. However, there is further evidence of
n2:mentions
n3:6742132
Subject Item
_:vb54525956
rdf:type
n2:Context
rdf:value
The quantity and volume of fluorescent tracers injected to outline the basement membrane pathways for drainage of ISF from grey matter [>>24<<] are too small to be detected in the cervical lymph nodes.
n2:mentions
n3:18208483
Subject Item
_:vb54525957
rdf:type
n2:Context
rdf:value
In these mice, the amount of Aβ in the cervical lymph nodes reflects the degree of production of mutant Aβ in the brain parenchyma [>>105<<].
n2:mentions
n3:25102344
Subject Item
_:vb54525958
rdf:type
n2:Context
rdf:value
Impairment is associated with age-related changes in the artery walls and biochemical changes in vascular basement membranes [>>52<<–55]. It is also possible to block the perivascular drainage pathways along arterial basement membranes acutely as demonstrated by the impairment of drainage when Immune complexes lodge in arterial basement membranes [27]. Epigenetic
n2:mentions
n3:25345857 n3:21259015 n3:23413811 n3:22848551
Subject Item
_:vb54525959
rdf:type
n2:Context
rdf:value
It is also possible to block the perivascular drainage pathways along arterial basement membranes acutely as demonstrated by the impairment of drainage when Immune complexes lodge in arterial basement membranes [>>27<<]. Epigenetic modifications of the proteins that constitute the extracellular matrix appear to have a role in the properties of the cerebrovascular basement membranes [83] and may be involved in the impaired drainage of fluid and solutes
n2:mentions
n3:24252464
Subject Item
_:vb54525960
rdf:type
n2:Context
rdf:value
Epigenetic modifications of the proteins that constitute the extracellular matrix appear to have a role in the properties of the cerebrovascular basement membranes [>>83<<] and may be involved in the impaired drainage of fluid and solutes from the brain associated with hyperlipidaemia [53].
n2:mentions
n3:25797609
Subject Item
_:vb54525961
rdf:type
n2:Context
rdf:value
constitute the extracellular matrix appear to have a role in the properties of the cerebrovascular basement membranes [83] and may be involved in the impaired drainage of fluid and solutes from the brain associated with hyperlipidaemia [>>53<<].
n2:mentions
n3:25345857
Subject Item
_:vb54525962
rdf:type
n2:Context
rdf:value
One of the factors involved in the aetiology of WMH appears to be impaired drainage of fluid along intramural perivascular pathways in cerebral arteries affected by cerebral amyloid angiopathy [>>140<<]. Similarly, the occurrence of amyloid-related imaging abnormalities (ARIA) in the white matter of patients treated with Aβ immunotherapy for Alzheimer’s disease may be due to the increase in accumulation of Aβ in intramural perivascular
n2:mentions
n3:25521178
Subject Item
_:vb54525963
rdf:type
n2:Context
rdf:value
that perivascular transport only occurs in living animals and ceases immediately after cardiac arrest suggests that pulsations in artery walls may generate the motive force for the transport of ISF and solutes out of the brain [>>24<<]. Furthermore, mathematical models indicate that perivascular transport of ISF and solutes may be driven by the contrary (reflection) waves that follow each pulse wave [119].
n2:mentions
n3:18208483
Subject Item
_:vb54525964
rdf:type
n2:Context
rdf:value
Furthermore, mathematical models indicate that perivascular transport of ISF and solutes may be driven by the contrary (reflection) waves that follow each pulse wave [>>119<<]. The contrary wave travels in the reverse direction to the major pulse wave and in the reverse direction to the flow of blood. If the contrary wave does act as the motive force for the drainage of ISF and solutes, then the model dictates
n2:mentions
n3:16112683
Subject Item
_:vb54525965
rdf:type
n2:Context
rdf:value
contrary wave does act as the motive force for the drainage of ISF and solutes, then the model dictates that some form of valve-like action is required to prevent reflux during the passage of the major pulse wave along the vessel wall [>>119<<]. As the route of drainage is within basement membranes [24], it is possible that the valve-like action results from changes in the orientation of the molecules within the basement membranes [122].
n2:mentions
n3:16112683
Subject Item
_:vb54525966
rdf:type
n2:Context
rdf:value
As the route of drainage is within basement membranes [>>24<<], it is possible that the valve-like action results from changes in the orientation of the molecules within the basement membranes [122].
n2:mentions
n3:18208483
Subject Item
_:vb54525967
rdf:type
n2:Context
rdf:value
As the route of drainage is within basement membranes [24], it is possible that the valve-like action results from changes in the orientation of the molecules within the basement membranes [>>122<<]. As vessels age, they become arteriosclerotic, stiff, and less elastic, particularly in humans, and such stiffening may interfere with perivascular drainage of ISF and soluble metabolites in elderly individuals [59, 139].
n2:mentions
n3:26399987
Subject Item
_:vb54525968
rdf:type
n2:Context
rdf:value
As vessels age, they become arteriosclerotic, stiff, and less elastic, particularly in humans, and such stiffening may interfere with perivascular drainage of ISF and soluble metabolites in elderly individuals [>>59<<, 139].
n2:mentions
n3:25894876
Subject Item
_:vb54525969
rdf:type
n2:Context
rdf:value
As vessels age, they become arteriosclerotic, stiff, and less elastic, particularly in humans, and such stiffening may interfere with perivascular drainage of ISF and soluble metabolites in elderly individuals [59, >>139<<].
n2:mentions
n3:25814152
Subject Item
_:vb54525970
rdf:type
n2:Context
rdf:value
Ischaemic stroke as well as amyloid accumulation results in a failure of perivascular clearance of solutes in the affected hemisphere [>>10<<]. Cerebral hypoperfusion in a mouse model of Alzheimer’s disease leads to accelerated accumulation of Aβ in the walls of leptomeningeal vessels and this can be reversed by phosphodiesterase inhibitor and vasodilator Cilostazol [102].
n2:mentions
n3:23818064
Subject Item
_:vb54525971
rdf:type
n2:Context
rdf:value
Cerebral hypoperfusion in a mouse model of Alzheimer’s disease leads to accelerated accumulation of Aβ in the walls of leptomeningeal vessels and this can be reversed by phosphodiesterase inhibitor and vasodilator Cilostazol [>>102<<]. Thus, experimental evidence again suggests that the interplay between the strength of pulsations and vasomotion may be key to the efficient perivascular clearance along basement membranes.
n2:mentions
n3:22170742
Subject Item
_:vb54525972
rdf:type
n2:Context
rdf:value
When horseradish peroxidase or fluorescent tracers are infused into the cerebral CSF, they enter the surface of the brain along the outer aspects of penetrating arteries and mix with ISF in the ECS of the brain parenchyma [>>62<<, 113]. Entry of tracers in the CSF into the brain is along basement membranes between the outer pial coating of the artery and glia limitans [91] (Fig. 4) and appears to be driven by arterial pulsations [62, 113]. Mixing of CSF with ISF
n2:mentions
n3:22896675
Subject Item
_:vb54525973
rdf:type
n2:Context
rdf:value
When horseradish peroxidase or fluorescent tracers are infused into the cerebral CSF, they enter the surface of the brain along the outer aspects of penetrating arteries and mix with ISF in the ECS of the brain parenchyma [62, >>113<<]. Entry of tracers in the CSF into the brain is along basement membranes between the outer pial coating of the artery and glia limitans [91] (Fig. 4) and appears to be driven by arterial pulsations [62, 113]. Mixing of CSF with ISF is
n2:mentions
n3:3971148
Subject Item
_:vb54525974
rdf:type
n2:Context
rdf:value
4) and appears to be driven by arterial pulsations [>>62<<, 113]. Mixing of CSF with ISF is dependent upon the presence of astrocytic aquaporin 4 [62].
n2:mentions
n3:22896675
Subject Item
_:vb54525975
rdf:type
n2:Context
rdf:value
4) and appears to be driven by arterial pulsations [62, >>113<<]. Mixing of CSF with ISF is dependent upon the presence of astrocytic aquaporin 4 [62].
n2:mentions
n3:3971148
Subject Item
_:vb54525976
rdf:type
n2:Context
rdf:value
Mixing of CSF with ISF is dependent upon the presence of astrocytic aquaporin 4 [>>62<<]. Clearance of tracers that enter the brain from the CSF appears to be via paravenous flow either into the CSF or possibly to cervical lymph nodes [62]. The immunological significance of the convective tracer influx/glymphatic system [62,
n2:mentions
n3:22896675
Subject Item
_:vb54525977
rdf:type
n2:Context
rdf:value
Clearance of tracers that enter the brain from the CSF appears to be via paravenous flow either into the CSF or possibly to cervical lymph nodes [>>62<<]. The immunological significance of the convective tracer influx/glymphatic system [62, 113] is unclear. Fluid and tissue metabolites in this system appear to drain back into the CSF and may reach lymph nodes via the CSF.
n2:mentions
n3:22896675
Subject Item
_:vb54525978
rdf:type
n2:Context
rdf:value
The immunological significance of the convective tracer influx/glymphatic system [>>62<<, 113] is unclear.
n2:mentions
n3:22896675
Subject Item
_:vb54525979
rdf:type
n2:Context
rdf:value
The immunological significance of the convective tracer influx/glymphatic system [62, >>113<<] is unclear.
n2:mentions
n3:3971148
Subject Item
_:vb54525980
rdf:type
n4:Section
dc:title
pathways for the migration of antigen-presenting cells from the cns to regional lymph nodes
n4:contains
_:vb54525981 _:vb54525982 _:vb54525983 _:vb54525984 _:vb54525985
Subject Item
_:vb54525981
rdf:type
n2:Context
rdf:value
the CNS parenchyma are fourfold: (1) transformation into another functional subset, e.g., adoptively transferred Th17 cells changing into Th1 or IFN-gamma producing cells, or Th1* (IFN-gamma and IL-17 producing cells) or even Th2 cells [>>23<<], (2) eventual demise in situ and uptake by phagocytic cells, (3) long-term residence, that is presumably rare, and (4) emigration to secondary lymphoid organs.
n2:mentions
n3:24316973
Subject Item
_:vb54525982
rdf:type
n2:Context
rdf:value
In contrast, the spleens of adjuvant controls and untreated monkeys were almost completely devoid of cells containing myelin basic protein and proteolipid protein [>>36<<].
n2:mentions
n3:12421916
Subject Item
_:vb54525983
rdf:type
n2:Context
rdf:value
Using a chronic-relapsing EAE model in Biozzi ABH mice, van Zwam et al. [>>135<<] surgically removed a total of thirteen lymph nodes draining the CNS:
n2:mentions
n3:19023878
Subject Item
_:vb54525984
rdf:type
n2:Context
rdf:value
Furtado et al. [>>44<<] had similar results upon extirpation of deep and superficial cervical lymph nodes in a transgenic spontaneous EAE model, as did Phillips et al. [106] in a cryolesion-enhanced model of cerebral EAE.
n2:mentions
n3:18802067
Subject Item
_:vb54525985
rdf:type
n2:Context
rdf:value
Furtado et al. [44] had similar results upon extirpation of deep and superficial cervical lymph nodes in a transgenic spontaneous EAE model, as did Phillips et al. [>>106<<] in a cryolesion-enhanced model of cerebral EAE.
n2:mentions
n3:9306968
Subject Item
_:vb54525986
rdf:type
n4:Section
dc:title
efferent pathways between lymph nodes and the cns
n4:contains
_:vb54526052 _:vb54526053 _:vb54526048 _:vb54526049 _:vb54526050 _:vb54526051 _:vb54526028 _:vb54526029 _:vb54526030 _:vb54526031 _:vb54526024 _:vb54526025 _:vb54526026 _:vb54526027 _:vb54526020 _:vb54526021 _:vb54526022 _:vb54526023 _:vb54526016 _:vb54526017 _:vb54526018 _:vb54526019 _:vb54526044 _:vb54526045 _:vb54526046 _:vb54526047 _:vb54526040 _:vb54526041 _:vb54526042 _:vb54526043 _:vb54526036 _:vb54526037 _:vb54526038 _:vb54526039 _:vb54526032 _:vb54526033 _:vb54526034 _:vb54526035 _:vb54525996 _:vb54525997 _:vb54525998 _:vb54525999 _:vb54525992 _:vb54525993 _:vb54525994 _:vb54525995 _:vb54525988 _:vb54525989 _:vb54525990 _:vb54525991 _:vb54525987 _:vb54526012 _:vb54526013 _:vb54526014 _:vb54526015 _:vb54526008 _:vb54526009 _:vb54526010 _:vb54526011 _:vb54526004 _:vb54526005 _:vb54526006 _:vb54526007 _:vb54526000 _:vb54526001 _:vb54526002 _:vb54526003
Subject Item
_:vb54525987
rdf:type
n2:Context
rdf:value
The deep cervical and lumbar lymph nodes have been shown to a function as lymph nodes that drain the CNS [>>34<<]. Thus, effector T and B cells specifically targeting CNS antigens could well be activated in cervical and lumbar lymph nodes and might be imprinted there with CNS-specific-trafficking programs similar to those described above for lymph
n2:mentions
n3:1463583
Subject Item
_:vb54525988
rdf:type
n2:Context
rdf:value
routes and molecular mechanisms involved in the trafficking of immune cells from secondary immune organs into the CNS is mostly derived from studies in murine EAE, an animal model for MS that is focussed mainly on the spinal cord [>>39<<]. EAE can be induced by subcutaneous immunization of susceptible mice or rats with neuroantigens emulsified in adjuvants.
n2:mentions
n3:22926201
Subject Item
_:vb54525989
rdf:type
n2:Context
rdf:value
In this case, autoreactive effector T cells that are normal constituents of the immune repertoire [>>103<<, 120] are activated in lymph nodes draining the skin.
n2:mentions
n3:1694970
Subject Item
_:vb54525990
rdf:type
n2:Context
rdf:value
In this case, autoreactive effector T cells that are normal constituents of the immune repertoire [103, >>120<<] are activated in lymph nodes draining the skin.
n2:mentions
n3:2413113
Subject Item
_:vb54525991
rdf:type
n2:Context
rdf:value
Previous studies have provided direct evidence for the migration of low numbers of encephalitogenic T-cell blast across the BBB in the spinal cord within several hours after transfer [>>56<<, 134]. However, recent studies performed in a Lewis rat model of EAE have shown that the majority of intravenously inoculated encephalitogenic T-cell blasts do not directly cross CNS microvessels, but rather accumulate in the lung [43,
n2:mentions
n3:1669702
Subject Item
_:vb54525992
rdf:type
n2:Context
rdf:value
Previous studies have provided direct evidence for the migration of low numbers of encephalitogenic T-cell blast across the BBB in the spinal cord within several hours after transfer [56, >>134<<]. However, recent studies performed in a Lewis rat model of EAE have shown that the majority of intravenously inoculated encephalitogenic T-cell blasts do not directly cross CNS microvessels, but rather accumulate in the lung [43, 100].
n2:mentions
n3:11518729
Subject Item
_:vb54525993
rdf:type
n2:Context
rdf:value
However, recent studies performed in a Lewis rat model of EAE have shown that the majority of intravenously inoculated encephalitogenic T-cell blasts do not directly cross CNS microvessels, but rather accumulate in the lung [>>43<<, 100]. In the lung and its draining lymph nodes, the T-cell blasts were found to profoundly reprogram their gene expression profile, i.e., they upregulated a migratory program involving adhesion molecules, motility factors, and chemokine
n2:mentions
n3:11371357
Subject Item
_:vb54525994
rdf:type
n2:Context
rdf:value
However, recent studies performed in a Lewis rat model of EAE have shown that the majority of intravenously inoculated encephalitogenic T-cell blasts do not directly cross CNS microvessels, but rather accumulate in the lung [43, >>100<<]. In the lung and its draining lymph nodes, the T-cell blasts were found to profoundly reprogram their gene expression profile, i.e., they upregulated a migratory program involving adhesion molecules, motility factors, and chemokine
n2:mentions
n3:22914092
Subject Item
_:vb54525995
rdf:type
n2:Context
rdf:value
blasts were found to profoundly reprogram their gene expression profile, i.e., they upregulated a migratory program involving adhesion molecules, motility factors, and chemokine receptors, but down-regulated their activation program [>>100<<]. These newly-gained migratory properties enabled that these T cells to efficiently cross the BBB [13, 68].
n2:mentions
n3:22914092
Subject Item
_:vb54525996
rdf:type
n2:Context
rdf:value
These newly-gained migratory properties enabled that these T cells to efficiently cross the BBB [>>13<<, 68]. Interestingly, encephalitogenic T cells were also shown to persist as long-lived memory cells within the lung tissue, where they could be stimulated to gain the competence to enter the CNS and trigger autoimmune disease within the
n2:mentions
n3:19829296
Subject Item
_:vb54525997
rdf:type
n2:Context
rdf:value
These newly-gained migratory properties enabled that these T cells to efficiently cross the BBB [13, >>68<<]. Interestingly, encephalitogenic T cells were also shown to persist as long-lived memory cells within the lung tissue, where they could be stimulated to gain the competence to enter the CNS and trigger autoimmune disease within the CNS.
n2:mentions
n3:15939794
Subject Item
_:vb54525998
rdf:type
n2:Context
rdf:value
Epidemiological studies suggest that infections of the respiratory tract play an important role in triggering relapses in MS, i.e., relapses in MS regularly follow inflammation of the respiratory tract [>>124<<]. Therefore, it is quite conceivable that stimulatory environmental factors might directly elicit a pathogenic response of autoimmune T cells within the lung. These studies indicate that, in addition to the cervical lymph nodes and the
n2:mentions
n3:2860501
Subject Item
_:vb54525999
rdf:type
n2:Context
rdf:value
These studies indicate that, in addition to the cervical lymph nodes and the gut [>>18<<], the lung can also serve as a location, where autoreactive T cells potentially become re-activated.
n2:mentions
n3:22031325
Subject Item
_:vb54526000
rdf:type
n2:Context
rdf:value
that have directly addressed the early migratory steps of T cells into the CNS have mostly been performed in the framework of EAE and have suggested three potential routes of entry for encephalitogenic T cells into the CNS (reviewed in [>>39<<]) (Fig. 5).
n2:mentions
n3:22926201
Subject Item
_:vb54526001
rdf:type
n2:Context
rdf:value
Live cell-imaging studies have provided evidence for the migration of encephalitogenic CD4+ Th 1 cells across leptomeningeal vessels associated with the spinal cord and the brain [>>13<<, 107, 134]. Migration is achieved by engaging constitutively expressed VCAM-1 on the BBB endothelium with activated α4β1-integrins expressed on the surface of the activated CD4+ Th1 cells [107, 134] (Fig.
n2:mentions
n3:19829296
Subject Item
_:vb54526002
rdf:type
n2:Context
rdf:value
Live cell-imaging studies have provided evidence for the migration of encephalitogenic CD4+ Th 1 cells across leptomeningeal vessels associated with the spinal cord and the brain [13, >>107<<, 134]. Migration is achieved by engaging constitutively expressed VCAM-1 on the BBB endothelium with activated α4β1-integrins expressed on the surface of the activated CD4+ Th1 cells [107, 134] (Fig.
n2:mentions
n3:11823530
Subject Item
_:vb54526003
rdf:type
n2:Context
rdf:value
Live cell-imaging studies have provided evidence for the migration of encephalitogenic CD4+ Th 1 cells across leptomeningeal vessels associated with the spinal cord and the brain [13, 107, >>134<<]. Migration is achieved by engaging constitutively expressed VCAM-1 on the BBB endothelium with activated α4β1-integrins expressed on the surface of the activated CD4+ Th1 cells [107, 134] (Fig.
n2:mentions
n3:11518729
Subject Item
_:vb54526004
rdf:type
n2:Context
rdf:value
Migration is achieved by engaging constitutively expressed VCAM-1 on the BBB endothelium with activated α4β1-integrins expressed on the surface of the activated CD4+ Th1 cells [>>107<<, 134] (Fig.
n2:mentions
n3:11823530
Subject Item
_:vb54526005
rdf:type
n2:Context
rdf:value
Migration is achieved by engaging constitutively expressed VCAM-1 on the BBB endothelium with activated α4β1-integrins expressed on the surface of the activated CD4+ Th1 cells [107, >>134<<] (Fig. 5a).
n2:mentions
n3:11518729
Subject Item
_:vb54526006
rdf:type
n2:Context
rdf:value
Encephalitogenic T cells have also been shown to directly extravasate via the leptomeningeal microvessels into the subarachnoid space [>>13<<, 118] (Fig. 5b).
n2:mentions
n3:19829296
Subject Item
_:vb54526007
rdf:type
n2:Context
rdf:value
Encephalitogenic T cells have also been shown to directly extravasate via the leptomeningeal microvessels into the subarachnoid space [13, >>118<<] (Fig. 5b).
n2:mentions
n3:26863192
Subject Item
_:vb54526008
rdf:type
n2:Context
rdf:value
express the chemokine receptor CCR6 would appear to initiate EAE by crossing the blood–CSF barrier in the choroid plexus by engaging CCL20, which is produced by choroid plexus epithelial cells, but not by endothelial cells of the BBB [>>112<<]. With the ventricular CSF, the CD4+ Th17 cells seem to travel to the leptomeningeal (subarachnoid) spaces, where they accumulate and trigger neuroinflammation [111, 112] (Fig.
n2:mentions
n3:19305396
Subject Item
_:vb54526009
rdf:type
n2:Context
rdf:value
With the ventricular CSF, the CD4+ Th17 cells seem to travel to the leptomeningeal (subarachnoid) spaces, where they accumulate and trigger neuroinflammation [>>111<<, 112] (Fig.
n2:mentions
n3:22903150
Subject Item
_:vb54526010
rdf:type
n2:Context
rdf:value
With the ventricular CSF, the CD4+ Th17 cells seem to travel to the leptomeningeal (subarachnoid) spaces, where they accumulate and trigger neuroinflammation [111, >>112<<] (Fig. 5c).
n2:mentions
n3:19305396
Subject Item
_:vb54526011
rdf:type
n2:Context
rdf:value
In healthy individuals, it is mostly central memory T cells and B cells and low numbers of innate immune cells that are detected in the CSF [>>7<<, 46, 71, 111]. This further underscores the ability of activated T and B cells to breach the outer brain barriers in the absence of neuroinflammation and perform immunosurveillance of the CNS by entering the CSF spaces.
n2:mentions
n3:24818670
Subject Item
_:vb54526012
rdf:type
n2:Context
rdf:value
In healthy individuals, it is mostly central memory T cells and B cells and low numbers of innate immune cells that are detected in the CSF [7, >>46<<, 71, 111]. This further underscores the ability of activated T and B cells to breach the outer brain barriers in the absence of neuroinflammation and perform immunosurveillance of the CNS by entering the CSF spaces.
n2:mentions
n3:12714572
Subject Item
_:vb54526013
rdf:type
n2:Context
rdf:value
In healthy individuals, it is mostly central memory T cells and B cells and low numbers of innate immune cells that are detected in the CSF [7, 46, >>71<<, 111]. This further underscores the ability of activated T and B cells to breach the outer brain barriers in the absence of neuroinflammation and perform immunosurveillance of the CNS by entering the CSF spaces.
n2:mentions
n3:12829791
Subject Item
_:vb54526014
rdf:type
n2:Context
rdf:value
In healthy individuals, it is mostly central memory T cells and B cells and low numbers of innate immune cells that are detected in the CSF [7, 46, 71, >>111<<]. This further underscores the ability of activated T and B cells to breach the outer brain barriers in the absence of neuroinflammation and perform immunosurveillance of the CNS by entering the CSF spaces.
n2:mentions
n3:22903150
Subject Item
_:vb54526015
rdf:type
n2:Context
rdf:value
endothelial BBB or the epithelial blood–CSF barrier, T cells will encounter APC that are resident in the CNS and strategically localized in perivenular spaces and in CSF drained spaces right behind these brain barriers (summarized in [>>39<<, 111]). While the perivascular spaces around post-capillary venules harbour rare DCs [48], large numbers of macrophages are found in the subarachnoid spaces [13].
n2:mentions
n3:22926201
Subject Item
_:vb54526016
rdf:type
n2:Context
rdf:value
BBB or the epithelial blood–CSF barrier, T cells will encounter APC that are resident in the CNS and strategically localized in perivenular spaces and in CSF drained spaces right behind these brain barriers (summarized in [39, >>111<<]). While the perivascular spaces around post-capillary venules harbour rare DCs [48], large numbers of macrophages are found in the subarachnoid spaces [13].
n2:mentions
n3:22903150
Subject Item
_:vb54526017
rdf:type
n2:Context
rdf:value
While the perivascular spaces around post-capillary venules harbour rare DCs [>>48<<], large numbers of macrophages are found in the subarachnoid spaces [13].
n2:mentions
n3:15735653
Subject Item
_:vb54526018
rdf:type
n2:Context
rdf:value
While the perivascular spaces around post-capillary venules harbour rare DCs [48], large numbers of macrophages are found in the subarachnoid spaces [>>13<<]. In addition, cells that express MHC class II (Kolmer or epiplexus cells) adhere as APC to the apical aspect of the choroid plexus epithelial cells that form the blood–CSF barrier [78]. In the framework of EAE, it has been shown that the
n2:mentions
n3:19829296
Subject Item
_:vb54526019
rdf:type
n2:Context
rdf:value
In addition, cells that express MHC class II (Kolmer or epiplexus cells) adhere as APC to the apical aspect of the choroid plexus epithelial cells that form the blood–CSF barrier [>>78<<]. In the framework of EAE, it has been shown that the recognition of their cognate antigen on these APC is prerequisite for the subsequent migration of CD4+ T cells across the glia limitans into the CNS parenchyma to cause clinical EAE
n2:mentions
n3:9550136
Subject Item
_:vb54526020
rdf:type
n2:Context
rdf:value
In the framework of EAE, it has been shown that the recognition of their cognate antigen on these APC is prerequisite for the subsequent migration of CD4+ T cells across the glia limitans into the CNS parenchyma to cause clinical EAE [>>13<<]. Direct evidence for this scenario has been derived from live cell-imaging studies of the spinal cord leptomeningeal spaces.
n2:mentions
n3:19829296
Subject Item
_:vb54526021
rdf:type
n2:Context
rdf:value
T cells having crossed the blood–leptomeningeal barrier will encounter numerous macrophages distributed within the leptomeningeal 3D milieu. These cells actively scan their environment with their cell processes [>>13<<]. Effector T cells migrating within the leptomeningeal environment are in regular contact with these cells that constitutively express MHC class II molecules on their membrane surfaces and thus are able to present myelin antigens to the
n2:mentions
n3:19829296
Subject Item
_:vb54526022
rdf:type
n2:Context
rdf:value
within the leptomeningeal environment are in regular contact with these cells that constitutively express MHC class II molecules on their membrane surfaces and thus are able to present myelin antigens to the pathogenic effector T cells [>>13<<, 70, 99]. In fact, live cell-imaging studies with activation-driven biosensors are able to demonstrate that T cells recognize their cognate antigen on these APC [80, 92] (the cognate antigen is the antigen that the T cell first
n2:mentions
n3:19829296
Subject Item
_:vb54526023
rdf:type
n2:Context
rdf:value
the leptomeningeal environment are in regular contact with these cells that constitutively express MHC class II molecules on their membrane surfaces and thus are able to present myelin antigens to the pathogenic effector T cells [13, >>70<<, 99]. In fact, live cell-imaging studies with activation-driven biosensors are able to demonstrate that T cells recognize their cognate antigen on these APC [80, 92] (the cognate antigen is the antigen that the T cell first encountered
n2:mentions
n3:18496841
Subject Item
_:vb54526024
rdf:type
n2:Context
rdf:value
leptomeningeal environment are in regular contact with these cells that constitutively express MHC class II molecules on their membrane surfaces and thus are able to present myelin antigens to the pathogenic effector T cells [13, 70, >>99<<]. In fact, live cell-imaging studies with activation-driven biosensors are able to demonstrate that T cells recognize their cognate antigen on these APC [80, 92] (the cognate antigen is the antigen that the T cell first encountered and
n2:mentions
n3:18000062
Subject Item
_:vb54526025
rdf:type
n2:Context
rdf:value
In fact, live cell-imaging studies with activation-driven biosensors are able to demonstrate that T cells recognize their cognate antigen on these APC [>>80<<, 92] (the cognate antigen is the antigen that the T cell first encountered and which bound to its receptor and resulted in the cell proliferation and differentiation that generated the population of T cells sensitized to that antigen).
n2:mentions
n3:23624600
Subject Item
_:vb54526026
rdf:type
n2:Context
rdf:value
In fact, live cell-imaging studies with activation-driven biosensors are able to demonstrate that T cells recognize their cognate antigen on these APC [80, >>92<<] (the cognate antigen is the antigen that the T cell first encountered and which bound to its receptor and resulted in the cell proliferation and differentiation that generated the population of T cells sensitized to that antigen).
n2:mentions
n3:23685843
Subject Item
_:vb54526027
rdf:type
n2:Context
rdf:value
The resulting antigen-specific activation of the T cells is not only of relevance for the adherence of the T cells to the leptomeningeal milieu [>>118<<], but also for the consecutive expression of pro-inflammatory cytokine by the effector T cells that constitutes a crucial signal for the initiation of the parenchymal invasion of immune cells and the clinical autoimmune process [67].
n2:mentions
n3:26863192
Subject Item
_:vb54526028
rdf:type
n2:Context
rdf:value
[118], but also for the consecutive expression of pro-inflammatory cytokine by the effector T cells that constitutes a crucial signal for the initiation of the parenchymal invasion of immune cells and the clinical autoimmune process [>>67<<]. The local T-cell activation triggers inflammatory events that lead to the upregulation of additional adhesion molecules and chemokines on endothelium at the BBB and epithelium at the blood–CSF barrier, thus, allowing the recruitment of
n2:mentions
n3:14734524
Subject Item
_:vb54526029
rdf:type
n2:Context
rdf:value
Lack of T-cell activation by leptomeningeal macrophages will lead to T-cell detachment and their release into the CSF which flows largely driven by respiration rather than the cardiac cycle [>>37<<, 118] in this space.
n2:mentions
n3:25673843
Subject Item
_:vb54526030
rdf:type
n2:Context
rdf:value
Lack of T-cell activation by leptomeningeal macrophages will lead to T-cell detachment and their release into the CSF which flows largely driven by respiration rather than the cardiac cycle [37, >>118<<] in this space.
n2:mentions
n3:26863192
Subject Item
_:vb54526031
rdf:type
n2:Context
rdf:value
expression of ICAM-1, VCAM-1, and de-novo expression of P-selectin and other adhesion molecules) is mediated by a multi-step cascade starting with P-selectin glycoprotein-1 (PSGL-1)-mediated T cell rolling on endothelial P-selectin [>>116<<] (Fig. 6).
n2:mentions
n3:24740164
Subject Item
_:vb54526032
rdf:type
n2:Context
rdf:value
Subsequent polarization and extended crawling of the T cells against the direction of flow have been shown in vitro to be mediated by LFA-1 interaction with endothelial ICAM-1 and ICAM-2 as in other vascular beds [>>1<<].
n2:mentions
n3:25545837
Subject Item
_:vb54526033
rdf:type
n2:Context
rdf:value
Crawling of encephalitogenic T cells against the direction of blood flow on the luminal side of spinal cord meningeal vessels in vivo has first been observed during the initiation phase of EAE in a Lewis rat EAE model [>>13<<]. In this case, T-cell adhesion to the endothelium and subsequent crawling was significantly reduced by blocking the function of α4β1-integrins, but not LFA-1 [13].
n2:mentions
n3:19829296
Subject Item
_:vb54526034
rdf:type
n2:Context
rdf:value
In this case, T-cell adhesion to the endothelium and subsequent crawling was significantly reduced by blocking the function of α4β1-integrins, but not LFA-1 [>>13<<]. In addition, it has been proposed that the other adhesion molecules, such as ninjurin-1, ALCAM, and MCAM, participate in T-cell migration across the BBB [61]. A recent in vitro study showed that extensive crawling of encephalitogenic T
n2:mentions
n3:19829296
Subject Item
_:vb54526035
rdf:type
n2:Context
rdf:value
In addition, it has been proposed that the other adhesion molecules, such as ninjurin-1, ALCAM, and MCAM, participate in T-cell migration across the BBB [>>61<<]. A recent in vitro study showed that extensive crawling of encephalitogenic T cells against the blood flow is a unique characteristic when low levels of ICAM-1 are expressed on the BBB allowing the T cells to find sites for paracellular
n2:mentions
n3:22162058
Subject Item
_:vb54526036
rdf:type
n2:Context
rdf:value
vitro study showed that extensive crawling of encephalitogenic T cells against the blood flow is a unique characteristic when low levels of ICAM-1 are expressed on the BBB allowing the T cells to find sites for paracellular diapedesis [>>1<<]. Inflammatory stimuli increased the cell surface levels of ICAM-1 on the BBB endothelium, which abrogated extended T-cell crawling and allowed the T cells to cross the BBB via transcellular routes.
n2:mentions
n3:25545837
Subject Item
_:vb54526037
rdf:type
n2:Context
rdf:value
Similar mechanisms for trafficking across the BBB have also been shown for myeloid cells, including DC; this applies especially to the predominant role for α4-integrins [>>42<<, 63]. These findings have been translated to clinical use by treating relapsing-remitting MS with the humanized anti-α4-integrin antibody natalizumab [127].
n2:mentions
n3:12044977
Subject Item
_:vb54526038
rdf:type
n2:Context
rdf:value
Similar mechanisms for trafficking across the BBB have also been shown for myeloid cells, including DC; this applies especially to the predominant role for α4-integrins [42, >>63<<]. These findings have been translated to clinical use by treating relapsing-remitting MS with the humanized anti-α4-integrin antibody natalizumab [127].
n2:mentions
n3:20483748
Subject Item
_:vb54526039
rdf:type
n2:Context
rdf:value
These findings have been translated to clinical use by treating relapsing-remitting MS with the humanized anti-α4-integrin antibody natalizumab [>>127<<].
n2:mentions
n3:15931259
Subject Item
_:vb54526040
rdf:type
n2:Context
rdf:value
(MMP-2) and MMP-9 in perivascular and leptomeningeal myeloid cells leading to the cleavage of astrocyte dystroglycan which anchors the astrocyte foot processes to the parenchymal basement membrane of the glia limitans [>>4<<]. At the same time, the scavenger receptor CXCR7 is upregulated on the inflamed BBB endothelium leading to downregulation in the levels of the chemokine CXCL12 in the perivascular spaces which further facilitates mobilization of CXCR4+ T
n2:mentions
n3:16585265
Subject Item
_:vb54526041
rdf:type
n2:Context
rdf:value
on the inflamed BBB endothelium leading to downregulation in the levels of the chemokine CXCL12 in the perivascular spaces which further facilitates mobilization of CXCR4+ T cells from the perivascular space into the CNS parenchyma [>>31<<]. In the CSF, CXCL12 acts as a homeostatic chemokine that maintains the expression of its ligand CXCR4 by immune cells, keeping them in the subarachnoid space; this may be relevant for immune surveillance.
n2:mentions
n3:21300915
Subject Item
_:vb54526042
rdf:type
n2:Context
rdf:value
In humans, the glia limitans on the surface of the CNS is much thicker than in rodents and consists of multiple layers of astrocyte processes [>>5<<]. Although lymphocytes and APC readily penetrate the delicate glia limitans around post-capillary venules in the human brain, the penetration of inflammatory cells through the thicker glia limitans on the surface of the brain and spinal
n2:mentions
n3:3374751
Subject Item
_:vb54526043
rdf:type
n2:Context
rdf:value
For example, plaques of demyelination on the surface of the cerebral cortex in MS may be associated with inflammatory cells in the overlying subarachnoid space [>>57<<]. However, the penetration of such cells across the glia limitans is not seen. The apposition of inflammatory cells in the CSF and demyelination in the cerebral cortex suggests that the diffusion of soluble agents may either pass from CSF
n2:mentions
n3:25421634
Subject Item
_:vb54526044
rdf:type
n2:Context
rdf:value
The apposition of inflammatory cells in the CSF and demyelination in the cerebral cortex suggests that the diffusion of soluble agents may either pass from CSF into brain [>>57<<], or agents, such as cytokines, may defuse from the brain into the CSF and attract inflammatory cells to the subarachnoid space [8].
n2:mentions
n3:25421634
Subject Item
_:vb54526045
rdf:type
n2:Context
rdf:value
in the cerebral cortex suggests that the diffusion of soluble agents may either pass from CSF into brain [57], or agents, such as cytokines, may defuse from the brain into the CSF and attract inflammatory cells to the subarachnoid space [>>8<<].
n2:mentions
n3:1613459
Subject Item
_:vb54526046
rdf:type
n2:Context
rdf:value
between these steps serve as checkpoints, in which the molecular keys required for immune cells to breach the glia limitans and to enter the CNS parenchyma are dependent upon local recognition of CNS antigens by the invading T cells [>>38<<].
n2:mentions
n3:21349152
Subject Item
_:vb54526047
rdf:type
n2:Context
rdf:value
Although CD8 T cells contribute to immune surveillance of the CNS [>>22<<] and are key players in neuroinflammation [117], little is known about the cellular and molecular mechanisms involved in the migration of CD8 T cells into the CNS.
n2:mentions
n3:12731042
Subject Item
_:vb54526048
rdf:type
n2:Context
rdf:value
Although CD8 T cells contribute to immune surveillance of the CNS [22] and are key players in neuroinflammation [>>117<<], little is known about the cellular and molecular mechanisms involved in the migration of CD8 T cells into the CNS.
n2:mentions
n3:21910991
Subject Item
_:vb54526049
rdf:type
n2:Context
rdf:value
Interaction between PSGL-1 and P-selectin has been shown to contribute to the recruitment of human CD8 T cells in leptomeningeal brain vessels [>>14<<]. Recent development of mouse models of CNS autoimmunity driven by CD8 T cells has led to the identification of the first molecular mechanisms involved in cytotoxic CD8 T-cell migration into the CNS and has shown that these mechanisms are
n2:mentions
n3:12595306
Subject Item
_:vb54526050
rdf:type
n2:Context
rdf:value
Although α4β1-integrin is essential for CD8 T-cell entry into the CNS in vivo, the vascular ligand engaged was identified as junctional adhesion molecule-B (JAM-B) rather then VCAM-1 used by CD4+ T cells [>>84<<]. A recent side by side comparison of CD8 versus CD4 T-cell migration across an in vitro model of the BBB further substantiated that molecular mechanisms mediating the multistep extravasation of CD8+ T cells across the BBB are
n2:mentions
n3:26358409
Subject Item
_:vb54526051
rdf:type
n2:Context
rdf:value
CD4 T-cell migration across an in vitro model of the BBB further substantiated that molecular mechanisms mediating the multistep extravasation of CD8+ T cells across the BBB are distinguishable from those involved for CD4+ T cells [>>114<<] and thus need further investigation.
n2:mentions
n3:27338806
Subject Item
_:vb54526052
rdf:type
n2:Context
rdf:value
Although α4β1-integrins contribute to B cell and myeloid cell entries into the CNS [>>63<<, 77], the precise entry routes and molecular mechanisms involved in their multi-step recruitment across the brain barriers remain to be explored.
n2:mentions
n3:20483748
Subject Item
_:vb54526053
rdf:type
n2:Context
rdf:value
Although α4β1-integrins contribute to B cell and myeloid cell entries into the CNS [63, >>77<<], the precise entry routes and molecular mechanisms involved in their multi-step recruitment across the brain barriers remain to be explored.
n2:mentions
n3:25712734
Subject Item
_:vb54526054
rdf:type
n4:Section
dc:title
relationships between lymphatic drainage of the brain and neurological disease
n4:contains
_:vb54526068 _:vb54526069 _:vb54526070 _:vb54526064 _:vb54526065 _:vb54526066 _:vb54526067 _:vb54526060 _:vb54526061 _:vb54526062 _:vb54526063 _:vb54526056 _:vb54526057 _:vb54526058 _:vb54526059 _:vb54526055
Subject Item
_:vb54526055
rdf:type
n2:Context
rdf:value
This finding suggests that specific responses to CNS antigens are initiated within lymph nodes that drain the CNS [>>135<<]. Further evidence comes from the cryolesion-enhanced form of cerebral EAE in which the removal of deep cervical lymph nodes during the incubation period of EAE and at the same time as the cerebral cryolesion significantly reduces the
n2:mentions
n3:19023878
Subject Item
_:vb54526056
rdf:type
n2:Context
rdf:value
form of cerebral EAE in which the removal of deep cervical lymph nodes during the incubation period of EAE and at the same time as the cerebral cryolesion significantly reduces the burden of EAE in the cerebral hemispheres [>>106<<]. Transfer of lymphocytes from animals with cryolesion-EAE resulted in EAE lesions that were predominantly in the cerebral hemispheres [73].
n2:mentions
n3:9306968
Subject Item
_:vb54526057
rdf:type
n2:Context
rdf:value
Transfer of lymphocytes from animals with cryolesion-EAE resulted in EAE lesions that were predominantly in the cerebral hemispheres [>>73<<]. These results suggest that lymphocytes from donors with cryolesion-EAE target the brain in recipient animals in preference to the spinal cord. This might be due to tissue-specific cues influencing the function of DC in the draining
n2:mentions
n3:10365103
Subject Item
_:vb54526058
rdf:type
n2:Context
rdf:value
a focal cortical cryolesion injury initially involve chemokines, such as the macrophage chemoattractants CCL2 (MCP-1) and CCL12 (MCP-5), and the activities of afferent and efferent neuronal connections with the site of damage [>>129<<]. By analogy, similar factors may modulate or reactivate autoimmune inflammation in MS [129].
n2:mentions
n3:11138923
Subject Item
_:vb54526059
rdf:type
n2:Context
rdf:value
By analogy, similar factors may modulate or reactivate autoimmune inflammation in MS [>>129<<].
n2:mentions
n3:11138923
Subject Item
_:vb54526060
rdf:type
n2:Context
rdf:value
However, the resulting infiltration of immune cells into the CNS does not occur until weeks after the insult [>>79<<, 132].
n2:mentions
n3:22366759
Subject Item
_:vb54526061
rdf:type
n2:Context
rdf:value
However, the resulting infiltration of immune cells into the CNS does not occur until weeks after the insult [79, >>132<<].
n2:mentions
n3:26656646
Subject Item
_:vb54526062
rdf:type
n2:Context
rdf:value
In MS, neuronal antigens were present in pro-inflammatory antigen-presenting cells in cervical lymph nodes, whereas the majority of cells containing myelin were anti-inflammatory [>>136<<]. This may reflect a different origin of the cells or different drainage mechanisms.
n2:mentions
n3:19050840
Subject Item
_:vb54526063
rdf:type
n2:Context
rdf:value
It was concluded from this study [>>136<<] that the type and frequencies of CNS antigens within the cervical lymph nodes are determined by the type and extent of CNS damage.
n2:mentions
n3:19050840
Subject Item
_:vb54526064
rdf:type
n2:Context
rdf:value
There is no evidence from clinical experience in MS that cervical lymph nodes are enlarged or reactive, but this does not appear to have been pursued by systematic imaging [>>40<<]. However, there is great promise and opportunity in the development of advanced imaging methods both in experimental animals, and in humans.
n2:mentions
n3:15748959
Subject Item
_:vb54526065
rdf:type
n2:Context
rdf:value
Progress in sonography, computed tomography, and magnetic resonance imaging could yield useful insights (reviewed in [>>75<<]), facilitated by the fact that cervical lymph nodes are relatively near to the skin.
n2:mentions
n3:25587368
Subject Item
_:vb54526066
rdf:type
n2:Context
rdf:value
restricted pathway for the elimination of ISF and solutes from its parenchyma to cervical lymph nodes that serves not only an immunological function but is also a pathway for the elimination of soluble metabolites from the brain [>>25<<]. This system of elimination fails with age [54], and this appears to be a major factor in the aetiology of CAA and Alzheimer’s disease.
n2:mentions
n3:23489283
Subject Item
_:vb54526067
rdf:type
n2:Context
rdf:value
This system of elimination fails with age [>>54<<], and this appears to be a major factor in the aetiology of CAA and Alzheimer’s disease.
n2:mentions
n3:21259015
Subject Item
_:vb54526068
rdf:type
n2:Context
rdf:value
Elimination of Aβ from the brain entails absorption into the blood, degradation by enzymes, such as neprilysin, and drainage, along intramural perivascular routes with ISF to lymph nodes [>>25<<]. With age and Alzheimer’s disease, insoluble fibrillary Aβ is deposited in intramural basement membranes of capillaries and arteries of the brain as CAA. Age-related changes in cerebral arteries impair intramural perivascular drainage of
n2:mentions
n3:23489283
Subject Item
_:vb54526069
rdf:type
n2:Context
rdf:value
Age-related changes in cerebral arteries impair intramural perivascular drainage of ISF [>>54<<], and this may be a trigger for the amyloid cascade, loss of homeostasis and propagation of tau protein in the brain in Alzheimer’s disease [139].
n2:mentions
n3:21259015
Subject Item
_:vb54526070
rdf:type
n2:Context
rdf:value
Age-related changes in cerebral arteries impair intramural perivascular drainage of ISF [54], and this may be a trigger for the amyloid cascade, loss of homeostasis and propagation of tau protein in the brain in Alzheimer’s disease [>>139<<].
n2:mentions
n3:25814152
Subject Item
_:vb54526071
rdf:type
n4:Section
dc:title
immune privilege
n4:contains
_:vb54526072 _:vb54526073 _:vb54526074
Subject Item
_:vb54526072
rdf:type
n2:Context
rdf:value
The original experiments demonstrating immune privilege in the brain showed that skin grafts directly implanted into the brain survived, but were rejected when similar grafts were placed on the skin [>>86<<]. However, if grafts extended into the ventricles and thus the CSF, they were rejected [86].
n2:mentions
n3:18865105
Subject Item
_:vb54526073
rdf:type
n2:Context
rdf:value
However, if grafts extended into the ventricles and thus the CSF, they were rejected [>>86<<]. It has also been shown by several groups and more recently directly by live cell imaging that activated T cells can enter the CSF in the leptomeningeal spaces irrespective of their antigen-specificity; this closely resembles the routine
n2:mentions
n3:18865105
Subject Item
_:vb54526074
rdf:type
n2:Context
rdf:value
that activated T cells can enter the CSF in the leptomeningeal spaces irrespective of their antigen-specificity; this closely resembles the routine immunosurveillance of tissues performed by T cells in organs other than the CNS [>>118<<]. These observations emphasise that, although there is immune privilege in the CNS, such privilege does not extend to the ventricles and leptomeningeal spaces that contain CSF.
n2:mentions
n3:26863192
Subject Item
_:vb611582418
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
28
n2:hasRelevantPaperId
n3:26030524
Subject Item
_:vb611582419
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
22
n2:hasRelevantPaperId
n3:26077718
Subject Item
_:vb611582420
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
12
n2:hasRelevantPaperId
n3:22896675
Subject Item
_:vb611582421
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
12
n2:hasRelevantPaperId
n3:28092374
Subject Item
_:vb611582422
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
12
n2:hasRelevantPaperId
n3:7510047
Subject Item
_:vb611582423
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
11
n2:hasRelevantPaperId
n3:18208483
Subject Item
_:vb611582424
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
11
n2:hasRelevantPaperId
n3:26975356
Subject Item
_:vb611582425
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
11
n2:hasRelevantPaperId
n3:29428972
Subject Item
_:vb611582426
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
10
n2:hasRelevantPaperId
n3:30046111
Subject Item
_:vb611582427
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
10
n2:hasRelevantPaperId
n3:29127332
Subject Item
_:vb611582428
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
9
n2:hasRelevantPaperId
n3:24136970
Subject Item
_:vb611582429
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
9
n2:hasRelevantPaperId
n3:28862640
Subject Item
_:vb611582430
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
9
n2:hasRelevantPaperId
n3:26993512
Subject Item
_:vb611582431
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
9
n2:hasRelevantPaperId
n3:20944627
Subject Item
_:vb611582432
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
9
n2:hasRelevantPaperId
n3:24227727
Subject Item
_:vb611582433
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
8
n2:hasRelevantPaperId
n3:29195051
Subject Item
_:vb611582434
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
8
n2:hasRelevantPaperId
n3:26195256
Subject Item
_:vb611582435
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
7
n2:hasRelevantPaperId
n3:27135602
Subject Item
_:vb611582436
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
7
n2:hasRelevantPaperId
n3:25947369
Subject Item
_:vb611582437
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
7
n2:hasRelevantPaperId
n3:19664713
Subject Item
_:vb611582438
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
7
n2:hasRelevantPaperId
n3:30224810
Subject Item
_:vb611582439
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
7
n2:hasRelevantPaperId
n3:6742132
Subject Item
_:vb611582440
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
6
n2:hasRelevantPaperId
n3:21840891
Subject Item
_:vb611582441
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
6
n2:hasRelevantPaperId
n3:23489283
Subject Item
_:vb611582442
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
6
n2:hasRelevantPaperId
n3:29754206
Subject Item
_:vb611582443
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
6
n2:hasRelevantPaperId
n3:16371949
Subject Item
_:vb611582444
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
6
n2:hasRelevantPaperId
n3:28969373
Subject Item
_:vb611582445
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
6
n2:hasRelevantPaperId
n3:16885505
Subject Item
_:vb611582446
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
6
n2:hasRelevantPaperId
n3:29141865
Subject Item
_:vb611582447
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
6
n2:hasRelevantPaperId
n3:29377008
Subject Item
_:vb611582448
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
6
n2:hasRelevantPaperId
n3:18363936
Subject Item
_:vb611582449
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
6
n2:hasRelevantPaperId
n3:27929105
Subject Item
_:vb611582450
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
6
n2:hasRelevantPaperId
n3:25471560
Subject Item
_:vb611582451
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
6
n2:hasRelevantPaperId
n3:22926201
Subject Item
_:vb611582452
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
6
n2:hasRelevantPaperId
n3:29023798
Subject Item
_:vb611582453
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
6
n2:hasRelevantPaperId
n3:30353860
Subject Item
_:vb611582454
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
6
n2:hasRelevantPaperId
n3:25204284
Subject Item
_:vb611582455
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
6
n2:hasRelevantPaperId
n3:16972896
Subject Item
_:vb611582456
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
6
n2:hasRelevantPaperId
n3:25678956
Subject Item
_:vb611582457
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
6
n2:hasRelevantPaperId
n3:19829296
Subject Item
_:vb611582458
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
6
n2:hasRelevantPaperId
n3:21259015
Subject Item
_:vb611582459
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
6
n2:hasRelevantPaperId
n3:31341278
Subject Item
_:vb611582460
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
6
n2:hasRelevantPaperId
n3:23695293
Subject Item
_:vb611582461
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
5
n2:hasRelevantPaperId
n3:26863192
Subject Item
_:vb611582462
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
5
n2:hasRelevantPaperId
n3:19002474
Subject Item
_:vb611582463
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
5
n2:hasRelevantPaperId
n3:16174293
Subject Item
_:vb611582464
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
5
n2:hasRelevantPaperId
n3:15141078
Subject Item
_:vb611582465
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
5
n2:hasRelevantPaperId
n3:28957666
Subject Item
_:vb611582466
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
5
n2:hasRelevantPaperId
n3:29368214
Subject Item
_:vb611582467
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
5
n2:hasRelevantPaperId
n3:15831717
Subject Item
_:vb611582468
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
5
n2:hasRelevantPaperId
n3:20976767
Subject Item
_:vb611582469
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
5
n2:hasRelevantPaperId
n3:22903150
Subject Item
_:vb611582470
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
5
n2:hasRelevantPaperId
n3:12130773
Subject Item
_:vb611582471
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
5
n2:hasRelevantPaperId
n3:23812703
Subject Item
_:vb611582472
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
5
n2:hasRelevantPaperId
n3:15735653
Subject Item
_:vb611582473
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
5
n2:hasRelevantPaperId
n3:2254158
Subject Item
_:vb611582474
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
5
n2:hasRelevantPaperId
n3:23818064
Subject Item
_:vb611582475
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
5
n2:hasRelevantPaperId
n3:11381080
Subject Item
_:vb611582476
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
5
n2:hasRelevantPaperId
n3:28847942
Subject Item
_:vb611582477
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
5
n2:hasRelevantPaperId
n3:16415867
Subject Item
_:vb611582478
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
4
n2:hasRelevantPaperId
n3:19339255
Subject Item
_:vb611582479
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
4
n2:hasRelevantPaperId
n3:28302766
Subject Item
_:vb611582480
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
4
n2:hasRelevantPaperId
n3:29873694
Subject Item
_:vb611582481
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
4
n2:hasRelevantPaperId
n3:24145049
Subject Item
_:vb611582482
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
4
n2:hasRelevantPaperId
n3:29740121
Subject Item
_:vb611582483
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
4
n2:hasRelevantPaperId
n3:19050840
Subject Item
_:vb611582484
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
4
n2:hasRelevantPaperId
n3:15193029
Subject Item
_:vb611582485
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
4
n2:hasRelevantPaperId
n3:27540163
Subject Item
_:vb611582486
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
4
n2:hasRelevantPaperId
n3:11120756
Subject Item
_:vb611582487
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
4
n2:hasRelevantPaperId
n3:29344300
Subject Item
_:vb611582488
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
4
n2:hasRelevantPaperId
n3:28446786
Subject Item
_:vb611582489
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
4
n2:hasRelevantPaperId
n3:25521178
Subject Item
_:vb611582490
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
4
n2:hasRelevantPaperId
n3:28029927
Subject Item
_:vb611582491
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
4
n2:hasRelevantPaperId
n3:15679948
Subject Item
_:vb611582492
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
4
n2:hasRelevantPaperId
n3:18865105
Subject Item
_:vb611582493
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
4
n2:hasRelevantPaperId
n3:10852536
Subject Item
_:vb611582494
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
4
n2:hasRelevantPaperId
n3:17438020
Subject Item
_:vb611582495
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
4
n2:hasRelevantPaperId
n3:25765070
Subject Item
_:vb611582496
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
4
n2:hasRelevantPaperId
n3:31942068
Subject Item
_:vb611582497
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
4
n2:hasRelevantPaperId
n3:28883786
Subject Item
_:vb611582498
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
4
n2:hasRelevantPaperId
n3:8987746
Subject Item
_:vb611582499
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
4
n2:hasRelevantPaperId
n3:23867200
Subject Item
_:vb611582500
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
4
n2:hasRelevantPaperId
n3:27227366
Subject Item
_:vb611582501
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
4
n2:hasRelevantPaperId
n3:3276004
Subject Item
_:vb611582502
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
4
n2:hasRelevantPaperId
n3:28971799
Subject Item
_:vb611582503
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
4
n2:hasRelevantPaperId
n3:28758994
Subject Item
_:vb611582504
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
4
n2:hasRelevantPaperId
n3:16585265
Subject Item
_:vb611582505
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
4
n2:hasRelevantPaperId
n3:6886750
Subject Item
_:vb611582506
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
4
n2:hasRelevantPaperId
n3:22064427
Subject Item
_:vb611582507
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
4
n2:hasRelevantPaperId
n3:29996134
Subject Item
_:vb611582508
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
4
n2:hasRelevantPaperId
n3:24088808
Subject Item
_:vb611582509
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
4
n2:hasRelevantPaperId
n3:27409813
Subject Item
_:vb611582510
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
4
n2:hasRelevantPaperId
n3:3971148
Subject Item
_:vb611582511
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
4
n2:hasRelevantPaperId
n3:26376966
Subject Item
_:vb611582512
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
4
n2:hasRelevantPaperId
n3:20439540
Subject Item
_:vb611582513
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
4
n2:hasRelevantPaperId
n3:26431936
Subject Item
_:vb611582514
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
4
n2:hasRelevantPaperId
n3:20944625
Subject Item
_:vb611582515
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
4
n2:hasRelevantPaperId
n3:7223890
Subject Item
_:vb611582516
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
4
n2:hasRelevantPaperId
n3:29426702
Subject Item
_:vb611582517
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
4
n2:hasRelevantPaperId
n3:12421916
Subject Item
_:vb611582518
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
4
n2:hasRelevantPaperId
n3:21148344
Subject Item
_:vb611582519
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
4
n2:hasRelevantPaperId
n3:21068832
Subject Item
_:vb611582520
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
4
n2:hasRelevantPaperId
n3:31270459
Subject Item
_:vb611582521
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
4
n2:hasRelevantPaperId
n3:25190438
Subject Item
_:vb611582522
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:27460561
Subject Item
_:vb611582523
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:27920202
Subject Item
_:vb611582524
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:28138136
Subject Item
_:vb611582525
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:30310148
Subject Item
_:vb611582526
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:8370472
Subject Item
_:vb611582527
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:10655103
Subject Item
_:vb611582528
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:16540683
Subject Item
_:vb611582529
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:22714021
Subject Item
_:vb611582530
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:24012647
Subject Item
_:vb611582531
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:16793937
Subject Item
_:vb611582532
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:19305396
Subject Item
_:vb611582533
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:1713524
Subject Item
_:vb611582534
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:32094452
Subject Item
_:vb611582535
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:8669469
Subject Item
_:vb611582536
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:22914092
Subject Item
_:vb611582537
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:26903861
Subject Item
_:vb611582538
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:20966214
Subject Item
_:vb611582539
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:26327684
Subject Item
_:vb611582540
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:20468051
Subject Item
_:vb611582541
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:23152628
Subject Item
_:vb611582542
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:30150661
Subject Item
_:vb611582543
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:25421634
Subject Item
_:vb611582544
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:32094487
Subject Item
_:vb611582545
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:26884166
Subject Item
_:vb611582546
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:21387374
Subject Item
_:vb611582547
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:25580734
Subject Item
_:vb611582548
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:27358487
Subject Item
_:vb611582549
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:22622580
Subject Item
_:vb611582550
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:23039106
Subject Item
_:vb611582551
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:11311463
Subject Item
_:vb611582552
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:29752066
Subject Item
_:vb611582553
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:24670647
Subject Item
_:vb611582554
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:21040844
Subject Item
_:vb611582555
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:29610928
Subject Item
_:vb611582556
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:27033548
Subject Item
_:vb611582557
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:27337340
Subject Item
_:vb611582558
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:4137563
Subject Item
_:vb611582559
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:7062119
Subject Item
_:vb611582560
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:12829791
Subject Item
_:vb611582561
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:30280653
Subject Item
_:vb611582562
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:24316888
Subject Item
_:vb611582563
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:15100718
Subject Item
_:vb611582564
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:26245965
Subject Item
_:vb611582565
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:590401
Subject Item
_:vb611582566
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:21349152
Subject Item
_:vb611582567
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:6685237
Subject Item
_:vb611582568
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:22632727
Subject Item
_:vb611582569
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:25823458
Subject Item
_:vb611582570
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:25888557
Subject Item
_:vb611582571
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:19779720
Subject Item
_:vb611582572
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:27530322
Subject Item
_:vb611582573
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:23434588
Subject Item
_:vb611582574
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:17129764
Subject Item
_:vb611582575
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:28798076
Subject Item
_:vb611582576
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:29420261
Subject Item
_:vb611582577
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:23609350
Subject Item
_:vb611582578
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:5765759
Subject Item
_:vb611582579
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:7356021
Subject Item
_:vb611582580
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:28903061
Subject Item
_:vb611582581
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:29101220
Subject Item
_:vb611582582
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:29653606
Subject Item
_:vb611582583
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:23945592
Subject Item
_:vb611582584
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:16476660
Subject Item
_:vb611582585
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:21291474
Subject Item
_:vb611582586
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:10911963
Subject Item
_:vb611582587
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:33462448
Subject Item
_:vb611582588
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:28886007
Subject Item
_:vb611582589
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:26247808
Subject Item
_:vb611582590
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:22144466
Subject Item
_:vb611582591
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:23412074
Subject Item
_:vb611582592
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:30602786
Subject Item
_:vb611582593
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:26005850
Subject Item
_:vb611582594
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:28288125
Subject Item
_:vb611582595
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:29061693
Subject Item
_:vb611582596
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:24566916
Subject Item
_:vb611582597
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:17140851
Subject Item
_:vb611582598
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:25561720
Subject Item
_:vb611582599
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:20610345
Subject Item
_:vb611582600
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:21990350
Subject Item
_:vb611582601
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:26590417
Subject Item
_:vb611582602
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:28844499
Subject Item
_:vb611582603
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:29518260
Subject Item
_:vb611582604
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:25891508
Subject Item
_:vb611582605
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:18083105
Subject Item
_:vb611582606
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:27697546
Subject Item
_:vb611582607
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:28092660
Subject Item
_:vb611582608
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:9736023
Subject Item
_:vb611582609
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:27551677
Subject Item
_:vb611582610
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:29283289
Subject Item
_:vb611582611
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:17077814
Subject Item
_:vb611582612
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:23635358
Subject Item
_:vb611582613
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:17828272
Subject Item
_:vb611582614
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:21738161
Subject Item
_:vb611582615
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:24056773
Subject Item
_:vb611582616
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:14734524
Subject Item
_:vb611582617
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:16636135
Subject Item
_:vb611582618
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:7223889
Subject Item
_:vb611582619
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:9418990
Subject Item
_:vb611582620
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:23126372
Subject Item
_:vb611582621
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:16355212
Subject Item
_:vb611582622
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:26713745
Subject Item
_:vb611582623
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:22030551
Subject Item
_:vb611582624
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:9883839
Subject Item
_:vb611582625
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:23413811
Subject Item
_:vb611582626
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:27234656
Subject Item
_:vb611582627
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:28292436
Subject Item
_:vb611582628
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:25307057
Subject Item
_:vb611582629
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:33508229
Subject Item
_:vb611582630
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:25908461
Subject Item
_:vb611582631
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:18026096
Subject Item
_:vb611582632
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:1341962
Subject Item
_:vb611582633
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:24828040
Subject Item
_:vb611582634
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:17620468
Subject Item
_:vb611582635
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:27459405
Subject Item
_:vb611582636
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:26546453
Subject Item
_:vb611582637
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:28099414
Subject Item
_:vb611582638
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:21839917
Subject Item
_:vb611582639
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:23597431
Subject Item
_:vb611582640
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:19023878
Subject Item
_:vb611582641
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:27001570
Subject Item
_:vb611582642
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:20720507
Subject Item
_:vb611582643
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:28826498
Subject Item
_:vb611582644
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
3
n2:hasRelevantPaperId
n3:26661250
Subject Item
_:vb611582645
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:21149252
Subject Item
_:vb611582646
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:8596936
Subject Item
_:vb611582647
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:10537110
Subject Item
_:vb611582648
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:29053035
Subject Item
_:vb611582649
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:11222803
Subject Item
_:vb611582650
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:23420871
Subject Item
_:vb611582651
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:12612547
Subject Item
_:vb611582652
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:24285616
Subject Item
_:vb611582653
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:24848101
Subject Item
_:vb611582654
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:31235908
Subject Item
_:vb611582655
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:25417164
Subject Item
_:vb611582656
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:25972006
Subject Item
_:vb611582657
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:19164813
Subject Item
_:vb611582658
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:21169520
Subject Item
_:vb611582659
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:28470822
Subject Item
_:vb611582660
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:10037799
Subject Item
_:vb611582661
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:11810184
Subject Item
_:vb611582662
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:30269986
Subject Item
_:vb611582663
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:30340601
Subject Item
_:vb611582664
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:30420755
Subject Item
_:vb611582665
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:30643288
Subject Item
_:vb611582666
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:17483690
Subject Item
_:vb611582667
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:18182301
Subject Item
_:vb611582668
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:26499397
Subject Item
_:vb611582669
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:4366438
Subject Item
_:vb611582670
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:27980126
Subject Item
_:vb611582671
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:8963753
Subject Item
_:vb611582672
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:10499794
Subject Item
_:vb611582673
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:10696507
Subject Item
_:vb611582674
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:22932670
Subject Item
_:vb611582675
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:23136223
Subject Item
_:vb611582676
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:29162645
Subject Item
_:vb611582677
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:11860459
Subject Item
_:vb611582678
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:29903035
Subject Item
_:vb611582679
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:30104766
Subject Item
_:vb611582680
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:15256471
Subject Item
_:vb611582681
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:25274032
Subject Item
_:vb611582682
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:25399804
Subject Item
_:vb611582683
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:25653369
Subject Item
_:vb611582684
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:19868782
Subject Item
_:vb611582685
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:20654699
Subject Item
_:vb611582686
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:27462115
Subject Item
_:vb611582687
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:27776109
Subject Item
_:vb611582688
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:21280082
Subject Item
_:vb611582689
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:28193695
Subject Item
_:vb611582690
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:22037947
Subject Item
_:vb611582691
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:22287710
Subject Item
_:vb611582692
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:28853674
Subject Item
_:vb611582693
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:23334579
Subject Item
_:vb611582694
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:29387036
Subject Item
_:vb611582695
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:29443965
Subject Item
_:vb611582696
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:24045166
Subject Item
_:vb611582697
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:30389931
Subject Item
_:vb611582698
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:15294142
Subject Item
_:vb611582699
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:24916913
Subject Item
_:vb611582700
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:25002752
Subject Item
_:vb611582701
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:16399703
Subject Item
_:vb611582702
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:16866984
Subject Item
_:vb611582703
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:31915375
Subject Item
_:vb611582704
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:26687838
Subject Item
_:vb611582705
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:19714497
Subject Item
_:vb611582706
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:19954936
Subject Item
_:vb611582707
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:28228568
Subject Item
_:vb611582708
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:10408445
Subject Item
_:vb611582709
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:23007702
Subject Item
_:vb611582710
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:30651548
Subject Item
_:vb611582711
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:15668734
Subject Item
_:vb611582712
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:24936446
Subject Item
_:vb611582713
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:31821174
Subject Item
_:vb611582714
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:17388955
Subject Item
_:vb611582715
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:22252717
Subject Item
_:vb611582716
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:22615835
Subject Item
_:vb611582717
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:16204309
Subject Item
_:vb611582718
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:16365086
Subject Item
_:vb611582719
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:31461408
Subject Item
_:vb611582720
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:16698083
Subject Item
_:vb611582721
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:16799555
Subject Item
_:vb611582722
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:32213628
Subject Item
_:vb611582723
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:32413299
Subject Item
_:vb611582724
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:17522861
Subject Item
_:vb611582725
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:25757756
Subject Item
_:vb611582726
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:27214551
Subject Item
_:vb611582727
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:21149665
Subject Item
_:vb611582728
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:21516112
Subject Item
_:vb611582729
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:28459441
Subject Item
_:vb611582730
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:28636961
Subject Item
_:vb611582731
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:28715552
Subject Item
_:vb611582732
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:28855621
Subject Item
_:vb611582733
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:22968321
Subject Item
_:vb611582734
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:23335631
Subject Item
_:vb611582735
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:29391404
Subject Item
_:vb611582736
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:11901243
Subject Item
_:vb611582737
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:15195085
Subject Item
_:vb611582738
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:31042697
Subject Item
_:vb611582739
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:25003359
Subject Item
_:vb611582740
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:25078775
Subject Item
_:vb611582741
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:25136634
Subject Item
_:vb611582742
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:31757960
Subject Item
_:vb611582743
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:31916277
Subject Item
_:vb611582744
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:17121744
Subject Item
_:vb611582745
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:25900222
Subject Item
_:vb611582746
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:26284939
Subject Item
_:vb611582747
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:26687840
Subject Item
_:vb611582748
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:26995317
Subject Item
_:vb611582749
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:27540165
Subject Item
_:vb611582750
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:3614542
Subject Item
_:vb611582751
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:28426845
Subject Item
_:vb611582752
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:28526764
Subject Item
_:vb611582753
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:28598415
Subject Item
_:vb611582754
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:10818495
Subject Item
_:vb611582755
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:23602162
Subject Item
_:vb611582756
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:12412020
Subject Item
_:vb611582757
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:30747918
Subject Item
_:vb611582758
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:31165009
Subject Item
_:vb611582759
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:25096616
Subject Item
_:vb611582760
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:25378163
Subject Item
_:vb611582761
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:19028999
Subject Item
_:vb611582762
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:19648929
Subject Item
_:vb611582763
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:27443914
Subject Item
_:vb611582764
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:20725515
Subject Item
_:vb611582765
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:27514673
Subject Item
_:vb611582766
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:6658996
Subject Item
_:vb611582767
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:23400708
Subject Item
_:vb611582768
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:12010739
Subject Item
_:vb611582769
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:23858432
Subject Item
_:vb611582770
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:31322758
Subject Item
_:vb611582771
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:16806499
Subject Item
_:vb611582772
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:32621291
Subject Item
_:vb611582773
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:26084936
Subject Item
_:vb611582774
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:18359102
Subject Item
_:vb611582775
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:26153041
Subject Item
_:vb611582776
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:26603901
Subject Item
_:vb611582777
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:19306372
Subject Item
_:vb611582778
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:20565964
Subject Item
_:vb611582779
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:22048062
Subject Item
_:vb611582780
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:28636962
Subject Item
_:vb611582781
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:28716371
Subject Item
_:vb611582782
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:22903149
Subject Item
_:vb611582783
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:12794167
Subject Item
_:vb611582784
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:30250261
Subject Item
_:vb611582785
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:24559670
Subject Item
_:vb611582786
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:25355681
Subject Item
_:vb611582787
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:31932797
Subject Item
_:vb611582788
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:25792098
Subject Item
_:vb611582789
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:33911285
Subject Item
_:vb611582790
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:27543501
Subject Item
_:vb611582791
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:28938276
Subject Item
_:vb611582792
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:29627873
Subject Item
_:vb611582793
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:30076374
Subject Item
_:vb611582794
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:24418464
Subject Item
_:vb611582795
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:24583233
Subject Item
_:vb611582796
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:15758009
Subject Item
_:vb611582797
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:16025095
Subject Item
_:vb611582798
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:25257319
Subject Item
_:vb611582799
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:32001524
Subject Item
_:vb611582800
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:17487182
Subject Item
_:vb611582801
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:25991443
Subject Item
_:vb611582802
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:19129672
Subject Item
_:vb611582803
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:26583089
Subject Item
_:vb611582804
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:26846644
Subject Item
_:vb611582805
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:27141419
Subject Item
_:vb611582806
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:22718543
Subject Item
_:vb611582807
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:23477737
Subject Item
_:vb611582808
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:24103194
Subject Item
_:vb611582809
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:30598527
Subject Item
_:vb611582810
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:16567637
Subject Item
_:vb611582811
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:25278937
Subject Item
_:vb611582812
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:20047691
Subject Item
_:vb611582813
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:20129251
Subject Item
_:vb611582814
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:27601434
Subject Item
_:vb611582815
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:3950724
Subject Item
_:vb611582816
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:28002679
Subject Item
_:vb611582817
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:21944997
Subject Item
_:vb611582818
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:22291210
Subject Item
_:vb611582819
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:9728088
Subject Item
_:vb611582820
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:29397420
Subject Item
_:vb611582821
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:23650139
Subject Item
_:vb611582822
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:15048884
Subject Item
_:vb611582823
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:25673843
Subject Item
_:vb611582824
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:33446503
Subject Item
_:vb611582825
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:26105538
Subject Item
_:vb611582826
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:19104149
Subject Item
_:vb611582827
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:19260033
Subject Item
_:vb611582828
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:26619118
Subject Item
_:vb611582829
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:19346498
Subject Item
_:vb611582830
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:26690495
Subject Item
_:vb611582831
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:26998085
Subject Item
_:vb611582832
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:345773
Subject Item
_:vb611582833
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:27239529
Subject Item
_:vb611582834
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:27338705
Subject Item
_:vb611582835
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:20851191
Subject Item
_:vb611582836
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:3117606
Subject Item
_:vb611582837
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:6411905
Subject Item
_:vb611582838
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:28031395
Subject Item
_:vb611582839
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:28229893
Subject Item
_:vb611582840
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:8419962
Subject Item
_:vb611582841
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:22759265
Subject Item
_:vb611582842
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:28939709
Subject Item
_:vb611582843
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:29570159
Subject Item
_:vb611582844
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:24583950
Subject Item
_:vb611582845
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:25100741
Subject Item
_:vb611582846
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:16775224
Subject Item
_:vb611582847
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:25392494
Subject Item
_:vb611582848
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:25448765
Subject Item
_:vb611582849
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:26312599
Subject Item
_:vb611582850
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:18873158
Subject Item
_:vb611582851
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:26442694
Subject Item
_:vb611582852
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:19132915
Subject Item
_:vb611582853
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:19201002
Subject Item
_:vb611582854
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:20197061
Subject Item
_:vb611582855
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:1373020
Subject Item
_:vb611582856
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:22022637
Subject Item
_:vb611582857
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:29039724
Subject Item
_:vb611582858
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:29755681
Subject Item
_:vb611582859
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:31604244
Subject Item
_:vb611582860
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:25340933
Subject Item
_:vb611582861
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:16960091
Subject Item
_:vb611582862
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:19226510
Subject Item
_:vb611582863
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:26745839
Subject Item
_:vb611582864
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:27327500
Subject Item
_:vb611582865
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:20924629
Subject Item
_:vb611582866
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:22466658
Subject Item
_:vb611582867
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:28860328
Subject Item
_:vb611582868
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:22829269
Subject Item
_:vb611582869
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:29400711
Subject Item
_:vb611582870
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:23575640
Subject Item
_:vb611582871
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:12640446
Subject Item
_:vb611582872
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:15489380
Subject Item
_:vb611582873
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:15846794
Subject Item
_:vb611582874
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:31051162
Subject Item
_:vb611582875
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:16281912
Subject Item
_:vb611582876
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:16732273
Subject Item
_:vb611582877
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:19018243
Subject Item
_:vb611582878
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:19265055
Subject Item
_:vb611582879
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:27496004
Subject Item
_:vb611582880
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:27721430
Subject Item
_:vb611582881
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:27810172
Subject Item
_:vb611582882
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:21778362
Subject Item
_:vb611582883
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:23462419
Subject Item
_:vb611582884
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:11958825
Subject Item
_:vb611582885
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:12417434
Subject Item
_:vb611582886
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:12834104
Subject Item
_:vb611582887
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:29988793
Subject Item
_:vb611582888
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:30760929
Subject Item
_:vb611582889
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:31078957
Subject Item
_:vb611582890
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:24946077
Subject Item
_:vb611582891
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:16547515
Subject Item
_:vb611582892
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:16650807
Subject Item
_:vb611582893
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:25687367
Subject Item
_:vb611582894
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:18923183
Subject Item
_:vb611582895
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:26711460
Subject Item
_:vb611582896
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:27141424
Subject Item
_:vb611582897
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:27582220
Subject Item
_:vb611582898
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:3796814
Subject Item
_:vb611582899
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:21349439
Subject Item
_:vb611582900
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:21799171
Subject Item
_:vb611582901
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:22442384
Subject Item
_:vb611582902
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:22722893
Subject Item
_:vb611582903
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:10858586
Subject Item
_:vb611582904
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:23307741
Subject Item
_:vb611582905
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:29437767
Subject Item
_:vb611582906
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:23553482
Subject Item
_:vb611582907
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:23709744
Subject Item
_:vb611582908
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:12578225
Subject Item
_:vb611582909
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:24029635
Subject Item
_:vb611582910
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:24357543
Subject Item
_:vb611582911
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:24601941
Subject Item
_:vb611582912
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:15717053
Subject Item
_:vb611582913
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:16960575
Subject Item
_:vb611582914
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:25704809
Subject Item
_:vb611582915
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:26090084
Subject Item
_:vb611582916
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:26463008
Subject Item
_:vb611582917
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:26869887
Subject Item
_:vb611582918
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:27025652
Subject Item
_:vb611582919
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:20056930
Subject Item
_:vb611582920
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:21296405
Subject Item
_:vb611582921
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:6155466
Subject Item
_:vb611582922
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:21737504
Subject Item
_:vb611582923
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:22664787
Subject Item
_:vb611582924
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:11240037
Subject Item
_:vb611582925
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:24305823
Subject Item
_:vb611582926
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:15056293
Subject Item
_:vb611582927
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:24925914
Subject Item
_:vb611582928
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:25361776
Subject Item
_:vb611582929
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:19169263
Subject Item
_:vb611582930
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:19349616
Subject Item
_:vb611582931
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:27725773
Subject Item
_:vb611582932
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:28043954
Subject Item
_:vb611582933
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:22857991
Subject Item
_:vb611582934
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:24336108
Subject Item
_:vb611582935
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:31178118
Subject Item
_:vb611582936
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:17715340
Subject Item
_:vb611582937
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:25862573
Subject Item
_:vb611582938
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:18604199
Subject Item
_:vb611582939
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:26973460
Subject Item
_:vb611582940
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:20738866
Subject Item
_:vb611582941
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:28396408
Subject Item
_:vb611582942
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:22150037
Subject Item
_:vb611582943
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:23233386
Subject Item
_:vb611582944
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:23316936
Subject Item
_:vb611582945
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:12430718
Subject Item
_:vb611582946
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:12743111
Subject Item
_:vb611582947
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:30815987
Subject Item
_:vb611582948
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:15956523
Subject Item
_:vb611582949
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:16230320
Subject Item
_:vb611582950
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:25828099
Subject Item
_:vb611582951
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:26471369
Subject Item
_:vb611582952
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:26682987
Subject Item
_:vb611582953
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:19786543
Subject Item
_:vb611582954
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:27403742
Subject Item
_:vb611582955
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:27608759
Subject Item
_:vb611582956
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:27852330
Subject Item
_:vb611582957
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:21371012
Subject Item
_:vb611582958
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:28003545
Subject Item
_:vb611582959
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:22393530
Subject Item
_:vb611582960
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:22907116
Subject Item
_:vb611582961
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:11923409
Subject Item
_:vb611582962
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:23752249
Subject Item
_:vb611582963
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:24309662
Subject Item
_:vb611582964
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:15067033
Subject Item
_:vb611582965
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:24625825
Subject Item
_:vb611582966
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:25013150
Subject Item
_:vb611582967
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:25611508
Subject Item
_:vb611582968
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:17470760
Subject Item
_:vb611582969
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:18007663
Subject Item
_:vb611582970
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:26030851
Subject Item
_:vb611582971
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:26300732
Subject Item
_:vb611582972
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:19019972
Subject Item
_:vb611582973
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:26775912
Subject Item
_:vb611582974
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:20081185
Subject Item
_:vb611582975
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:20178740
Subject Item
_:vb611582976
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:21701599
Subject Item
_:vb611582977
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:21779395
Subject Item
_:vb611582978
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:28235764
Subject Item
_:vb611582979
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:21995440
Subject Item
_:vb611582980
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:28541408
Subject Item
_:vb611582981
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:23187627
Subject Item
_:vb611582982
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:23296339
Subject Item
_:vb611582983
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:23692610
Subject Item
_:vb611582984
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:12843411
Subject Item
_:vb611582985
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:15695511
Subject Item
_:vb611582986
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:24817998
Subject Item
_:vb611582987
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:15930352
Subject Item
_:vb611582988
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:16039904
Subject Item
_:vb611582989
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:25186741
Subject Item
_:vb611582990
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:31883839
Subject Item
_:vb611582991
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:25398455
Subject Item
_:vb611582992
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:32376954
Subject Item
_:vb611582993
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:17302889
Subject Item
_:vb611582994
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:17619996
Subject Item
_:vb611582995
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:25995466
Subject Item
_:vb611582996
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:18619524
Subject Item
_:vb611582997
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:20107219
Subject Item
_:vb611582998
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:27916653
Subject Item
_:vb611582999
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:28135240
Subject Item
_:vb611583000
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:28961037
Subject Item
_:vb611583001
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:12433975
Subject Item
_:vb611583002
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:14704766
Subject Item
_:vb611583003
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:31332391
Subject Item
_:vb611583004
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:25285078
Subject Item
_:vb611583005
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:18553315
Subject Item
_:vb611583006
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:18809917
Subject Item
_:vb611583007
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:26748031
Subject Item
_:vb611583008
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:27027288
Subject Item
_:vb611583009
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:1463583
Subject Item
_:vb611583010
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:3551211
Subject Item
_:vb611583011
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:21300915
Subject Item
_:vb611583012
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:10934227
Subject Item
_:vb611583013
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:23160197
Subject Item
_:vb611583014
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:11557630
Subject Item
_:vb611583015
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:23443171
Subject Item
_:vb611583016
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:23653359
Subject Item
_:vb611583017
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:29618808
Subject Item
_:vb611583018
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:24137023
Subject Item
_:vb611583019
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:30326293
Subject Item
_:vb611583020
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:24569378
Subject Item
_:vb611583021
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:31063132
Subject Item
_:vb611583022
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:17272818
Subject Item
_:vb611583023
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:25727254
Subject Item
_:vb611583024
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:17682068
Subject Item
_:vb611583025
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:25982749
Subject Item
_:vb611583026
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:19269895
Subject Item
_:vb611583027
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:19828616
Subject Item
_:vb611583028
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:26952098
Subject Item
_:vb611583029
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:20179016
Subject Item
_:vb611583030
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:1928403
Subject Item
_:vb611583031
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:27729857
Subject Item
_:vb611583032
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:28161508
Subject Item
_:vb611583033
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:22226359
Subject Item
_:vb611583034
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:10190820
Subject Item
_:vb611583035
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:29089479
Subject Item
_:vb611583036
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:11596125
Subject Item
_:vb611583037
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:30471926
Subject Item
_:vb611583038
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:15931160
Subject Item
_:vb611583039
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:16936277
Subject Item
_:vb611583040
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:25589747
Subject Item
_:vb611583041
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:17619998
Subject Item
_:vb611583042
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:26733797
Subject Item
_:vb611583043
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:26912648
Subject Item
_:vb611583044
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:28188218
Subject Item
_:vb611583045
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:7910634
Subject Item
_:vb611583046
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:22366759
Subject Item
_:vb611583047
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:28627037
Subject Item
_:vb611583048
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:22811424
Subject Item
_:vb611583049
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:29106980
Subject Item
_:vb611583050
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:24366271
Subject Item
_:vb611583051
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:24552317
Subject Item
_:vb611583052
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:17638898
Subject Item
_:vb611583053
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:17846148
Subject Item
_:vb611583054
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:18375385
Subject Item
_:vb611583055
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:26353940
Subject Item
_:vb611583056
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:26993511
Subject Item
_:vb611583057
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:20142990
Subject Item
_:vb611583058
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:85446
Subject Item
_:vb611583059
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:8347303
Subject Item
_:vb611583060
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:28371827
Subject Item
_:vb611583061
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:23160472
Subject Item
_:vb611583062
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:11558796
Subject Item
_:vb611583063
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:29339443
Subject Item
_:vb611583064
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:12486269
Subject Item
_:vb611583065
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:30740048
Subject Item
_:vb611583066
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:16636173
Subject Item
_:vb611583067
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:17036005
Subject Item
_:vb611583068
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:25727737
Subject Item
_:vb611583069
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:18698034
Subject Item
_:vb611583070
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:19111869
Subject Item
_:vb611583071
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:19533601
Subject Item
_:vb611583072
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:20619340
Subject Item
_:vb611583073
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:9211853
Subject Item
_:vb611583074
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:29025771
Subject Item
_:vb611583075
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:11294783
Subject Item
_:vb611583076
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:23298378
Subject Item
_:vb611583077
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:24162655
Subject Item
_:vb611583078
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:24440640
Subject Item
_:vb611583079
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:16199517
Subject Item
_:vb611583080
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:25589753
Subject Item
_:vb611583081
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:32917953
Subject Item
_:vb611583082
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:19046364
Subject Item
_:vb611583083
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:26661200
Subject Item
_:vb611583084
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:27836940
Subject Item
_:vb611583085
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:5957959
Subject Item
_:vb611583086
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:22366799
Subject Item
_:vb611583087
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:28567588
Subject Item
_:vb611583088
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:10527772
Subject Item
_:vb611583089
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:28916821
Subject Item
_:vb611583090
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:23150934
Subject Item
_:vb611583091
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:23481704
Subject Item
_:vb611583092
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:29681904
Subject Item
_:vb611583093
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:12876559
Subject Item
_:vb611583094
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:15186921
Subject Item
_:vb611583095
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:31132378
Subject Item
_:vb611583096
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:25205593
Subject Item
_:vb611583097
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:25287860
Subject Item
_:vb611583098
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:18676439
Subject Item
_:vb611583099
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:27096319
Subject Item
_:vb611583100
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:21757525
Subject Item
_:vb611583101
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:11807399
Subject Item
_:vb611583102
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:16011870
Subject Item
_:vb611583103
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:16166562
Subject Item
_:vb611583104
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:31157827
Subject Item
_:vb611583105
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:1341963
Subject Item
_:vb611583106
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:1566067
Subject Item
_:vb611583107
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:21498572
Subject Item
_:vb611583108
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:28117416
Subject Item
_:vb611583109
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:21886162
Subject Item
_:vb611583110
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:28552391
Subject Item
_:vb611583111
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:29091775
Subject Item
_:vb611583112
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:24162737
Subject Item
_:vb611583113
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:25112380
Subject Item
_:vb611583114
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:25329858
Subject Item
_:vb611583115
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:18215617
Subject Item
_:vb611583116
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:18496841
Subject Item
_:vb611583117
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:26323545
Subject Item
_:vb611583118
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:26524530
Subject Item
_:vb611583119
rdf:type
n2:RelevantBibliographicResource
n2:RelevantScore
2
n2:hasRelevantPaperId
n3:26718201