. _:b78101400 . _:b648753925 . _:b648754377 "2"^^ . _:b648753570 "4"^^ . . _:b648754376 "2"^^ . _:b648753924 . _:b648753581 "4"^^ . . _:b648754379 "2"^^ . _:b648753927 . _:b648753785 . _:b648753580 "4"^^ . . _:b648754378 "2"^^ . _:b648753926 . _:b648753583 "4"^^ . . _:b648753952 . . _:b648754389 "2"^^ . _:b648753921 . _:b648753582 "4"^^ . _:b648754009 . . . _:b648754388 "2"^^ . _:b648753920 . . _:b648753577 "4"^^ . _:b648753950 . _:b648753784 . _:b648753480 . . _:b648753923 . _:b648754391 "2"^^ . _:b648753992 . _:b648753576 "4"^^ . . _:b648754390 "2"^^ . _:b648753922 . _:b648753579 "4"^^ . _:b648754327 . _:b648753933 . _:b648754385 "2"^^ . _:b648753964 . _:b648753578 "4"^^ . _:b648753932 . _:b648754384 "2"^^ . _:b648753589 "4"^^ . _:b648753439 . _:b648753935 . _:b648754387 "2"^^ . _:b648753588 "4"^^ . _:b648753422 . _:b648753934 . _:b648754386 "2"^^ . _:b648753591 "4"^^ . . _:b648753569 . _:b648753929 . _:b648754397 "2"^^ . _:b648753590 "4"^^ . _:b648753928 . _:b648754396 "2"^^ . _:b648753585 "4"^^ . . _:b648754374 . . _:b648753931 . _:b648754399 "2"^^ . _:b648753584 "4"^^ . _:b78101417 . _:b648753930 . _:b648754398 "2"^^ . _:b648753587 "4"^^ . . . _:b648754393 "2"^^ . _:b648754094 . _:b648753941 . _:b648753586 "4"^^ . _:b648753977 . _:b648753874 . . _:b648754392 "2"^^ . _:b648753940 . _:b648753597 "4"^^ . . . _:b648753547 . _:b648753943 . _:b648754395 "2"^^ . _:b648753596 "4"^^ . . _:b648754394 "2"^^ . _:b648753942 . _:b648753599 "4"^^ . . _:b648754018 . . _:b648753937 . _:b648754405 "2"^^ . _:b648753598 "4"^^ . . _:b648753936 . _:b648754404 "2"^^ . _:b648753593 "4"^^ . _:b648753939 . _:b648754407 "2"^^ . _:b648753592 "4"^^ . . . _:b648753938 . _:b648754406 "2"^^ . _:b648753595 "4"^^ . _:b648754290 . _:b648753949 . _:b648754401 "2"^^ . _:b648753594 "4"^^ . _:b648753848 . . _:b648753689 . _:b648753948 . _:b648754400 "2"^^ . _:b648753605 "4"^^ . . _:b648754403 "2"^^ . _:b648753951 . _:b648753604 "4"^^ . . . . _:b648753950 . _:b648754402 "2"^^ . _:b648753607 "4"^^ . _:b648753945 . _:b648754413 "2"^^ . _:b648753606 "4"^^ . _:b648753537 . _:b648753944 . _:b648754412 "2"^^ . _:b648753601 "4"^^ . _:b648753947 . _:b648754415 "2"^^ . _:b648753600 "4"^^ . _:b648754130 . _:b648753503 . _:b648754414 "2"^^ . _:b648754044 . _:b648753946 . _:b648753470 . _:b648753603 "4"^^ . _:b648753560 . _:b648753957 . _:b648754409 "2"^^ . _:b648753602 "4"^^ . _:b648753960 . . . _:b648754408 "2"^^ . _:b648753956 . _:b648753613 "4"^^ . _:b648753959 . _:b648754411 "2"^^ . _:b648753612 "4"^^ . _:b648753625 . _:b648754410 "2"^^ . _:b648753958 . _:b648753615 "4"^^ . _:b648754313 . . . _:b648754421 "2"^^ . _:b648753953 . _:b648753614 "4"^^ . . _:b648754420 "2"^^ . _:b648753952 . _:b648753609 "4"^^ . . _:b648753955 . _:b648754423 "2"^^ . _:b648753451 . _:b648753608 "4"^^ . . _:b648753954 . _:b648754422 "2"^^ . _:b648753611 "4"^^ . _:b648753968 . _:b648753717 . _:b648754417 "2"^^ . _:b648753965 . _:b648753610 "4"^^ . _:b648753964 . _:b648754416 "2"^^ . . _:b648753621 "4"^^ . _:b648754401 . _:b648753967 . _:b648754419 "2"^^ . . _:b648753620 "4"^^ . _:b648753582 . _:b648754407 . _:b648753966 . _:b648754418 "2"^^ . _:b648753623 "4"^^ . _:b78101387 . _:b648753961 . _:b648754429 "2"^^ . _:b648753622 "4"^^ . _:b648753383 . . . _:b648753960 . _:b648754428 "2"^^ . _:b648753617 "4"^^ . . _:b648753963 . _:b648754431 "2"^^ . _:b648754340 . _:b648753616 "4"^^ . . _:b648753867 . _:b648754430 "2"^^ . _:b648753962 . _:b648753619 "4"^^ . _:b648753606 . _:b648753782 . . . _:b648754425 "2"^^ . _:b648753973 . _:b648753618 "4"^^ . _:b648753743 . _:b648754424 "2"^^ . _:b648753972 . _:b648753629 "4"^^ . _:b648754237 . . . _:b648754427 "2"^^ . _:b648753975 . _:b648753628 "4"^^ . _:b648753548 . _:b648753974 . _:b648754426 "2"^^ . _:b648753631 "4"^^ . . _:b648753969 . _:b648754437 "2"^^ . _:b648753630 "4"^^ . . _:b648753968 . _:b648754436 "2"^^ . _:b648753625 "4"^^ . _:b648754216 . _:b648753741 . _:b648753971 . _:b648754439 "2"^^ . . _:b648753624 "4"^^ . _:b648754321 . . _:b648753970 . _:b648754438 "2"^^ . _:b648753627 "4"^^ . . _:b648754269 . . . _:b648754433 "2"^^ . _:b648753981 . _:b648753626 "4"^^ . . . _:b648754432 "2"^^ . _:b648753980 . _:b648753637 "4"^^ . _:b648753983 . _:b648754435 "2"^^ . . _:b648753636 "4"^^ . . _:b648753982 . _:b648754434 "2"^^ . _:b648753639 "4"^^ . _:b648753977 . _:b648754445 "2"^^ . _:b648754396 . . _:b648753638 "4"^^ . . _:b648753976 . _:b648754444 "2"^^ . _:b648753633 "4"^^ . _:b648753829 . _:b648753979 . _:b648754447 "2"^^ . _:b648753632 "4"^^ . . . _:b648753978 . _:b648754446 "2"^^ . _:b648753635 "4"^^ . _:b648753989 . _:b648754441 "2"^^ . _:b648753634 "4"^^ . _:b648753762 . _:b648753645 "3"^^ . _:b648754440 "2"^^ . _:b648753988 . _:b648754212 . . _:b648753613 . _:b648753644 "3"^^ . _:b648754443 "2"^^ . _:b648754251 . _:b648753991 . _:b648753798 . . _:b648753647 "3"^^ . _:b648754442 "2"^^ . _:b648753990 . . _:b648753646 "3"^^ . _:b648753985 . _:b648753896 . _:b648753555 . _:b648753984 . . . _:b648753883 . _:b648753641 "4"^^ . . _:b648753987 . _:b648753640 "4"^^ . . _:b648753796 . _:b648753986 . _:b648753643 "3"^^ . _:b648753797 . _:b648753798 . _:b648753799 . _:b648753792 . _:b648754449 "2"^^ . _:b648753997 . _:b648753642 "3"^^ . _:b648753793 . _:b648753794 . _:b78101398 . _:b648754098 . . _:b648753795 . _:b648753804 . _:b648754448 "2"^^ . _:b648753996 . _:b648753760 . _:b648753653 "3"^^ . _:b648753805 . _:b648753532 . . _:b648753806 . . _:b648753807 . _:b648753477 . . _:b648753800 . _:b648753999 . _:b648753652 "3"^^ . _:b648753801 . _:b648754405 . _:b648753802 . _:b648753895 . _:b648753803 . _:b648753812 . _:b648753998 . _:b648753655 "3"^^ . . _:b648753813 . _:b648753814 . _:b648753815 . _:b648753808 . _:b648754014 . _:b648753993 . _:b648753654 "3"^^ . . _:b648753809 . _:b648753810 . . _:b648753811 . _:b648753820 . _:b648753992 . _:b648753806 . _:b648753649 "3"^^ . _:b648753566 . . _:b648753821 . _:b648753822 . . _:b648753823 . _:b648753816 . _:b78101401 . _:b648753995 . _:b648753648 "3"^^ . _:b648753817 . _:b648753818 . _:b648753819 . _:b648753679 . . _:b648753828 . _:b648753994 . _:b648753651 "3"^^ . _:b648753829 . _:b648753610 . _:b648753830 . _:b648753831 . _:b648753824 . _:b648754005 . _:b648753650 "3"^^ . _:b648753825 . _:b648753826 . _:b648753942 . _:b648753827 . _:b648753836 . _:b648754004 . _:b648753661 "3"^^ . _:b648753837 . _:b648754002 . _:b648753838 . . _:b648753839 . _:b648753832 . _:b648754007 . _:b648753946 . _:b648753660 "3"^^ . _:b648753833 . _:b648753834 . _:b648753835 . _:b648753844 . _:b648754006 . _:b648753663 "3"^^ . _:b648753845 . _:b648753846 . _:b648753847 . _:b648753840 . _:b648754001 . _:b648753756 . _:b648753662 "3"^^ . _:b648753626 . _:b648753841 . _:b648753429 . _:b648753842 . _:b648753843 . _:b648753852 . _:b648754000 . _:b648753657 "3"^^ . _:b648753853 . _:b648753854 . _:b648753855 . _:b648753848 . _:b648754003 . _:b648753656 "3"^^ . _:b648753849 . _:b648753850 . . . _:b648753851 . _:b648753860 . _:b648754002 . _:b648753987 . _:b648753659 "3"^^ . _:b648753861 . . _:b648753862 . _:b648753863 . _:b648754004 . . _:b648754013 . _:b648753658 "3"^^ . _:b648753856 . _:b648753857 . _:b648753858 . _:b648753859 . _:b648753868 . _:b648754280 . _:b648754012 . _:b648753869 . _:b648753870 . _:b648753871 . _:b648753738 . _:b648753864 . _:b648754015 . _:b648753865 . _:b648753866 . _:b648753867 . _:b648753876 . _:b648754014 . _:b648753877 . _:b648754232 . . _:b648753878 . . _:b648753879 . _:b648753872 . _:b78101399 . _:b648754009 . _:b648753873 . . _:b648753874 . _:b648754357 . _:b648753875 . _:b648753884 . _:b648754008 . _:b648753885 . _:b648754183 . . . _:b648753886 . _:b648753887 . _:b648753880 . _:b78101417 . _:b648754011 . . _:b648753881 . _:b648753882 . _:b648753883 . _:b648753892 . _:b648754010 . _:b648753893 . _:b648753894 . . _:b648753895 . _:b648753888 . _:b648754021 . _:b648753889 . _:b648753890 . _:b648753891 . _:b648753900 . _:b648754020 . _:b648753922 . _:b648753901 . _:b648753666 . _:b648753902 . . _:b648753903 . _:b648753896 . _:b648754080 . _:b648754023 . _:b648753897 . _:b648753923 . . _:b648753898 . _:b648753899 . _:b648753908 . _:b648754022 . . . _:b648753909 . _:b648753910 . _:b648753911 . _:b648753904 . _:b648754178 . _:b648754017 . _:b648753905 . _:b648753906 . _:b648753907 . _:b648753916 . _:b648754016 . . _:b648753917 . _:b648753918 . _:b648753919 . _:b648753912 . _:b78101381 "The ITT population (n\u2009=\u2009331) (Table\u00A01) is similar to other recent glioblastoma trials [4, 21, >>24<<], with 61% males (n\u2009=\u2009202) and 39% females (n\u2009=\u2009129), with 75.2% of the patients\u2009\u2265\u200950\u00A0years of age (range 19\u201373\u00A0years), and median KPS of 90." . _:b648754019 . _:b648753913 . _:b648753914 . . _:b648753915 . _:b78101393 "discussion" . _:b648753668 . _:b648754334 . _:b648754018 . _:b648753669 . _:b648754087 . _:b648753670 . _:b648753671 . . _:b648753664 . _:b648754029 . _:b648753665 . _:b648753666 . _:b648753667 . _:b648753676 . _:b648754028 . _:b648753677 . _:b648754247 . _:b648753678 . . _:b648753679 . _:b648754036 . . _:b648753672 . _:b648754031 . _:b648753673 . _:b648753530 . _:b648753674 . _:b648753675 . _:b648753684 . _:b648754030 . _:b648753685 . _:b648753686 . _:b648753687 . _:b648753680 . _:b648754025 . _:b648753681 . . _:b648753682 . _:b648753683 . _:b648753692 . _:b648754024 . _:b648753693 . _:b648753694 . . _:b648753695 . _:b648753688 . _:b648754027 . _:b648753689 . _:b648753690 . _:b648753691 . . _:b648753700 . _:b648754026 . _:b648753701 . _:b648753702 . . _:b648753703 . . _:b648753696 . _:b648754037 . _:b648753697 . _:b648753698 . _:b648753699 . _:b648753753 . _:b648753708 . _:b648754036 . _:b648753709 . _:b648754326 . _:b648753710 . _:b648753711 . _:b648753704 . _:b648754039 . . . _:b648753705 . _:b648753467 . _:b648753706 . _:b648753707 . _:b648754431 . _:b648753716 . _:b648754038 . _:b648753717 . _:b648753718 . . . _:b648753719 . _:b648753712 . _:b648754033 . _:b648753713 . _:b648754058 . _:b648753907 . _:b648753714 . _:b648753715 . _:b648754163 . _:b648753724 . _:b648754032 . . . _:b648753725 . _:b648753726 . _:b648753727 . _:b648753720 . _:b648754035 . _:b648754032 . _:b648753721 . _:b648753722 . . _:b648753723 . _:b648753732 . _:b648754249 . _:b648754034 . _:b648753802 . . _:b648753733 . _:b648753734 . _:b648753735 . _:b648753728 . _:b648754045 . . _:b648753729 . _:b648753730 . _:b648754307 . . _:b648753731 . _:b648753740 . _:b648754044 . _:b648753741 . _:b648753742 . _:b648753743 . _:b648754255 . _:b648753736 . _:b648754063 . _:b648754047 . _:b648753394 . _:b648753737 . _:b648753738 . _:b648753739 . _:b648753748 . _:b648754046 . _:b648753749 . _:b648753750 . . _:b648753751 . _:b648753744 . _:b648754041 . _:b648753745 . _:b648753746 . _:b648753747 . . _:b648753756 . _:b648754040 . _:b648753757 . _:b648753758 . _:b648753759 . _:b648753752 . _:b648754043 . _:b648753753 . _:b648753754 . _:b648753755 . _:b648753622 . _:b648753764 . _:b648754042 . _:b648753565 . _:b648753765 . _:b648753440 . _:b648753766 . . _:b648753767 . _:b648753760 . _:b648754053 . _:b648753761 . _:b648753762 . _:b648753967 . _:b648753593 . _:b648753763 . _:b648753772 . _:b648754052 . _:b648753773 . _:b648753986 . _:b648753774 . _:b648753775 . _:b648754049 . _:b648753768 . _:b648754055 . _:b648753769 . _:b648753590 . . _:b648753770 . _:b648753771 . _:b648753780 . _:b648754054 . . _:b648753781 . _:b648753782 . _:b648753783 . _:b648753776 . _:b648754049 . _:b648753777 . _:b648753778 . _:b648753779 . . _:b648753788 . _:b648754114 . _:b648754069 . _:b648754048 . . _:b648753789 . _:b648754286 . _:b648753790 . _:b648753791 . . _:b648753784 . _:b648754051 . . _:b648753785 . _:b648753786 . _:b648753787 . _:b648754052 . _:b648754065 . _:b648754050 . _:b648754053 . _:b648753609 . _:b648754054 . _:b648753417 . _:b648754055 . _:b648754048 . _:b648754140 . _:b648754061 . _:b648754049 . _:b648754050 . _:b648753683 . _:b648754051 . . . _:b648754060 . _:b648754060 . _:b648754061 . _:b648753797 . _:b648754062 . _:b648753972 . _:b648754063 . _:b648754056 . _:b648754063 . _:b648754057 . _:b78101386 "In multiple reported studies, neither bevacizumab nor CCNU have been shown to extend survival [9, >>25<<]." . _:b648754058 . _:b648753833 . _:b648754059 . . _:b648754068 . _:b648754062 . _:b648754069 . . _:b648754070 . _:b648754071 . . _:b648754057 . _:b648754064 . _:b648754065 . _:b648754066 . _:b648754067 . . _:b648754076 . _:b648754056 . _:b648753914 . _:b648753813 . _:b648754077 . _:b648754352 . _:b648754078 . _:b648754079 . _:b648754072 . _:b648754059 . . _:b648754073 . _:b648754074 . _:b648754075 . _:b648754084 . _:b648754058 . _:b648753815 . _:b648754085 . _:b648754086 . . _:b648754087 . _:b648754080 . _:b648754069 . _:b648754081 . . _:b648754082 . _:b648754083 . _:b648754092 . _:b648754068 . _:b648754093 . _:b648753432 . _:b648754094 . . _:b648754095 . _:b648754088 . _:b648754071 . . _:b648754089 . _:b648754090 . _:b648754091 . . _:b648754100 . _:b648754070 . . _:b648754101 . _:b648754102 . _:b648754103 . _:b648754096 . _:b648754065 . _:b648754097 . _:b648754028 . . _:b648754098 . _:b648754351 . _:b648754099 . _:b648753376 . _:b648754108 . _:b648754064 . _:b648754109 . _:b648754111 . _:b648754110 . _:b648754111 . . _:b648754104 . _:b648754067 . _:b648753604 . _:b648754105 . _:b648754106 . _:b648754107 . _:b648754116 . _:b648754066 . . . _:b648754117 . _:b648754118 . _:b648754119 . _:b648754112 . _:b648754077 . _:b648754113 . _:b648753379 . _:b648754114 . _:b648754115 . _:b648754124 . _:b648754076 . _:b648754125 . _:b648753409 . _:b648754126 . _:b648754127 . _:b648754120 . _:b648754079 . _:b648754121 . _:b648754122 . _:b648753843 . _:b648754123 . _:b648754132 . _:b648754078 . . _:b648753941 . _:b648753617 . _:b648754133 . _:b648754134 . _:b648754224 . _:b648754135 . _:b648754128 . _:b648754073 . _:b648753596 . _:b648754129 . _:b648754130 . _:b648754131 . _:b648754140 . _:b648754072 . _:b648753631 . _:b648754141 . _:b648754142 . . _:b648754143 . _:b648753635 . _:b648754136 . _:b648754075 . _:b648754137 . _:b648754138 . _:b648754139 . _:b648754148 . _:b648754074 . _:b648753534 . _:b648754149 . _:b648754150 . _:b648754151 . _:b648754144 . _:b648754085 . _:b648753983 . _:b648753576 . _:b648754145 . _:b648753879 . _:b648754146 . _:b648754408 . _:b648754147 . _:b648754156 . _:b648754084 . _:b648754157 . _:b648754158 . _:b648754159 . . _:b648754087 . _:b648754152 . _:b648754153 . _:b648754154 . _:b648754155 . _:b648754164 . _:b648754086 . . _:b648754165 . _:b648754166 . _:b648754167 . . _:b648754160 . _:b648754081 . _:b648753490 . _:b648754161 . _:b648754162 . _:b648754163 . _:b78101405 "Glioblastoma is the most aggressive primary malignant brain tumor in adults [>>1<<]. Standard of care (SOC) consists of surgical resection followed by 6\u00A0weeks of daily radiotherapy with concurrent temozolomide, then monthly temozolomide [2]." . _:b648754172 . _:b648754080 . _:b648754173 . _:b648754174 . _:b648754175 . _:b648754168 . _:b648754083 . _:b648754169 . _:b648754170 . . _:b648754171 . _:b648753924 . _:b648754082 . _:b648753925 . _:b648754001 . _:b648753673 . _:b648753926 . _:b648754060 . _:b648753927 . _:b648753920 . _:b648754093 . _:b648753466 . _:b648753921 . . . _:b648753922 . _:b648753923 . _:b648753932 . _:b648754092 . _:b648753933 . _:b648753934 . _:b648753935 . _:b648753928 . _:b648754095 . . _:b648753929 . _:b648753930 . _:b648753931 . _:b648753940 . _:b648754094 . . _:b648753941 . _:b648753942 . _:b648753943 . _:b648753657 . _:b648753936 . _:b648754170 . _:b648754089 . . _:b648753937 . _:b648753873 . _:b648753938 . _:b648753852 . . _:b648753939 . _:b648753948 . _:b648754088 . . _:b648753949 . . _:b648753950 . _:b648753951 . _:b648753944 . _:b648754091 . _:b648753700 . _:b648753945 . . _:b648753946 . _:b648753947 . _:b648753956 . _:b648754090 . _:b648753957 . _:b648753958 . _:b648753959 . _:b648753952 . _:b648754101 . _:b648753953 . _:b648753954 . _:b648753955 . _:b648753380 . _:b648754100 . _:b648753964 . _:b648753965 . _:b648753966 . _:b648753967 . _:b648753960 . _:b648754103 . _:b648753961 . _:b648753962 . _:b648753811 . . _:b648753511 . . _:b648753963 . . _:b648753972 . _:b648754102 . _:b648753642 . _:b648753973 . _:b648753974 . _:b648753975 . _:b648753968 . _:b648754097 . _:b648753969 . _:b648753970 . _:b648753971 . _:b648753980 . _:b648754096 . _:b648753981 . _:b648753982 . _:b648753940 . _:b648753983 . _:b648753976 . _:b648754099 . _:b648753977 . _:b648753978 . _:b648753979 . _:b648753827 . . _:b648753988 . _:b648754098 . . . _:b648753989 . _:b648753990 . _:b648753589 . _:b648753991 . _:b648753984 . _:b648754109 . _:b648753985 . _:b648753986 . _:b648753987 . _:b648753996 . _:b648754108 . _:b648753997 . _:b648753998 . . _:b648753999 . _:b648753992 . _:b648754111 . _:b648753993 . _:b648753994 . _:b648753995 . _:b648754004 . _:b648754110 . _:b648754005 . _:b648754006 . . _:b648754007 . _:b648754000 . _:b648754105 . "PMC0" . _:b648754001 . . _:b648754122 . _:b648754002 . _:b648754003 . _:b648754275 . _:b648754012 . _:b648754104 . _:b648754013 . . _:b648754014 . . . _:b648754015 . _:b648754008 . _:b648754107 . . _:b648754009 . _:b648754010 . _:b648754274 . _:b648754011 . _:b648754020 . _:b648754106 . _:b648754021 . _:b648754022 . _:b648753390 . _:b648754023 . _:b648754016 . _:b648754117 . _:b648754017 . _:b648754018 . _:b648754019 . _:b648753862 . . _:b648754028 . _:b648754116 . _:b648754029 . _:b648754030 . _:b648754031 . _:b648754024 . _:b648754119 . _:b648754025 . _:b648754026 . . . _:b648754027 . _:b648754036 . _:b648754118 . _:b648754037 . _:b648754266 . _:b648754038 . _:b78101396 "The increase in survival in MGMT-methylated patients in the DCVax-L trial raises the possibility of a cooperative effect from the combination of temozolomide chemotherapy and the DCVax-L active immune therapy [>>17<<]." . _:b648754039 . _:b648754032 . _:b648754113 . . . _:b648754033 . . _:b648754034 . _:b648754392 . _:b648754035 . _:b648754044 . _:b648754112 . . _:b648754386 . _:b648754045 . _:b648754046 . _:b648754047 . _:b648754040 . _:b648754115 . _:b648754041 . _:b648754336 . . . _:b648754042 . _:b648754043 . . _:b648754114 . . . _:b648754125 . . _:b648754124 . . _:b648754127 . _:b648753735 . _:b648754062 . _:b648754126 . _:b648754121 . _:b648754120 . _:b648754123 . _:b648753559 . _:b648753448 . _:b648754122 . . . _:b648754133 . _:b648753901 . _:b648754132 . _:b648754380 . _:b648753393 . . _:b648754135 . . _:b648754337 . _:b648754134 . _:b648753799 . _:b648754129 . _:b648753494 . _:b648754239 . _:b648753781 . . _:b648754128 . . _:b648753830 . _:b648754131 . . _:b648754050 . _:b78101414 "For more than a decade, our group and others have been testing active vaccination strategies, such as DCs pulsed with tumor lysates or synthetic peptides to induce antitumor immunity in glioblastoma patients [>>12<<, 13]. We have previously demonstrated the effectiveness of DC vaccination in pre-clinical models [14\u201316], and early stage clinical trials have shown substantial promise [17\u201319]." . . _:b648754130 . _:b648754141 . _:b648753453 . _:b648754140 . _:b648753872 . _:b648753496 . . _:b648754143 . _:b648754310 . _:b648754142 . . _:b648753600 . _:b648754137 . _:b648754404 . _:b648754136 . _:b648753373 . _:b648753374 . _:b648754413 . _:b648753375 . . . . . _:b648754194 . _:b648754139 . . _:b78101412 . _:b648753771 . _:b648753567 . _:b648753380 . _:b648754138 . _:b648753726 . _:b648753381 . _:b648753382 . _:b648753383 . _:b648753686 . _:b648753376 . _:b648754149 . _:b648754092 . _:b648753377 . _:b648753378 . _:b648753379 . _:b648754370 . _:b648753388 . _:b648754148 . _:b648753800 . . _:b648753389 . _:b648753390 . _:b648753391 . _:b648753384 . _:b648754151 . _:b648753912 . . _:b648753385 . _:b648753386 . _:b648753387 . _:b648753396 . _:b648754150 . _:b648753397 . _:b648753966 . _:b648753398 . _:b648753399 . _:b648753392 . _:b648754145 . _:b648754005 . _:b648753393 . _:b648753394 . . . _:b648753395 . _:b648753404 . _:b648754144 . _:b648753405 . . _:b648753406 . _:b78101398 "Beneficial effects of immune therapies are often observed at later time points, in the tail of the survival curve [>>26<<]. Although this Phase 3 trial requires further maturation, a picture is beginning to emerge from the blinded interim data which is consistent with an extended survival tail." . _:b648754289 . _:b648753407 . _:b648753400 . _:b648754197 . _:b648754147 . _:b648753401 . _:b648753402 . _:b648753403 . _:b648754146 . _:b648753886 . _:b648753502 . _:b648754160 . _:b648754052 . _:b648754157 . _:b648754119 . _:b648754156 . _:b648754159 . . _:b648753472 . _:b648754158 . . _:b648754439 . _:b648754153 . _:b648754112 . _:b648754152 . _:b648754155 . _:b648754154 . . _:b648753909 . _:b648754165 . _:b648753556 . _:b648753661 . . . . _:b648754164 . _:b648753720 . . _:b648754167 . _:b648753573 . . _:b648754166 . . _:b648753913 . _:b648754161 . _:b648753461 . _:b648754160 . _:b648754163 . . _:b648754162 . . _:b648754173 . _:b648754172 . . _:b648754346 . _:b648754175 . _:b648754006 . _:b648754174 . . _:b648754169 . . _:b648753899 . _:b648754168 . . _:b78101403 "combined with a wide range of other treatment agents, including immune checkpoint inhibitors and targeted therapies, without resulting in undue toxicities for patients such as have been seen with some other treatment combinations [29, >>30<<]. Further studies to explore such combinations are warranted." . _:b648753401 . _:b648754171 . _:b648754333 . _:b648753544 . _:b648753476 . . _:b648753425 . _:b648754126 . _:b648754170 . _:b648754075 . . . _:b648753669 . _:b648753668 . . _:b648754221 . . . _:b648754344 . _:b648754155 . _:b648753671 . _:b648753670 . . . . _:b648753665 . . . . _:b648753664 . . _:b648753676 . . _:b648753744 . . _:b648753667 . _:b648753540 . _:b648753666 . _:b648753541 . _:b648753542 . _:b648753601 . _:b648753531 . _:b648753543 . . _:b648753677 . _:b648753536 . _:b648753537 . _:b648753538 . . _:b648753539 . _:b648753548 . _:b648753676 . _:b648753549 . _:b648753550 . _:b648753551 . _:b648753544 . _:b648753679 . . _:b648753545 . _:b648753546 . . _:b648753547 . _:b648753556 . _:b648753678 . _:b648753557 . . _:b648753558 . _:b648753559 . _:b648753552 . _:b648754107 . _:b648753673 . _:b648753553 . _:b648753554 . _:b648753555 . _:b648753564 . _:b648753672 . _:b648753565 . _:b648753566 . _:b648753978 . _:b648753611 . . _:b648754083 . _:b648753567 . _:b648753560 . _:b648753675 . _:b648753561 . _:b648753562 . _:b648753563 . _:b648753572 . _:b648753674 . _:b648753573 . . . . _:b648753574 . _:b648753575 . _:b648753568 . _:b648753685 . _:b648753569 . _:b648754445 . _:b648754391 . _:b648753570 . _:b648753571 . . . _:b648753684 . _:b648753580 . _:b648753581 . _:b648753582 . . _:b648753583 . . _:b648753576 . _:b648753687 . _:b648753577 . _:b648753578 . _:b648753579 . _:b648753588 . _:b648753686 . _:b648753589 . _:b648753590 . _:b648753591 . . _:b648753584 . _:b648753681 . _:b648753585 . _:b648753724 . _:b648753586 . _:b648753587 . _:b648753596 . _:b648754285 . _:b648753680 . . _:b648753597 . _:b648753841 . _:b648753598 . _:b648753599 . _:b648753592 . _:b648753683 . . . _:b648753593 . _:b648753594 . _:b648753595 . _:b648753604 . _:b648753682 . . _:b648753778 . _:b648753605 . _:b648753606 . . _:b648753607 . _:b648753600 . _:b648753693 . _:b648753601 . _:b648753602 . _:b648753627 . _:b648753603 . _:b648753612 . _:b648753692 . _:b648753613 . _:b648753614 . _:b648753615 . _:b648753608 . _:b648753695 . . _:b648753609 . _:b648754120 . . _:b648753610 . _:b648753611 . _:b648753620 . _:b648754037 . _:b648753694 . _:b648753469 . _:b648753621 . _:b648754134 . _:b648753622 . _:b648753623 . _:b648753616 . _:b648753689 . _:b648753617 . . . _:b648753618 . _:b648753619 . . _:b648753628 . _:b648754428 . _:b648753688 . _:b648753629 . _:b648753945 . _:b648753630 . _:b648753631 . . _:b648753624 . _:b648753691 . _:b648753553 . _:b648753625 . _:b648753626 . _:b648753627 . . . _:b648753690 . _:b648753636 . _:b648753637 . _:b648753638 . . _:b648753639 . _:b648753632 . _:b648754363 . _:b648753701 . _:b648753633 . _:b648753634 . _:b648753890 . _:b648753635 . _:b648753808 . _:b648753644 . _:b648753700 . _:b648753645 . _:b648754079 . . _:b648753646 . _:b648753647 . _:b648753640 . _:b648753703 . . . . _:b648753641 . _:b648753642 . _:b648753695 . _:b648753643 . _:b648753652 . _:b648753702 . _:b648753653 . _:b648753654 . _:b648754086 . _:b648753655 . _:b648753648 . _:b648753697 . _:b648753649 . _:b648753650 . _:b648753526 . . _:b648753651 . . _:b648753660 . _:b648754035 . _:b648753696 . _:b648753661 . . _:b648753662 . _:b648753663 . . _:b648753656 . _:b648753699 . _:b648753657 . _:b648753658 . _:b648753659 . _:b648753412 . _:b648753698 . _:b648753413 . _:b648753414 . _:b648753415 . _:b648753408 . _:b648753709 . _:b648753409 . . _:b648753410 . _:b648753846 . _:b648753411 . _:b648753420 . _:b648753708 . . _:b648753421 . _:b648753422 . _:b648754146 . . _:b648753423 . _:b648754082 . _:b648753416 . _:b648753711 . _:b648753417 . _:b648753418 . _:b648753419 . _:b648753419 . _:b648753583 . _:b648753428 . _:b648753710 . . _:b648753429 . _:b648753430 . _:b648753431 . . _:b648753705 . _:b648753424 . _:b648753505 . _:b648753425 . _:b648753460 . _:b648753426 . _:b648753427 . _:b648753436 . _:b648753704 . _:b648753437 . _:b648753438 . _:b648753777 . _:b648753439 . . _:b648753432 . _:b648753818 . _:b648753707 . _:b648753433 . _:b648753434 . . _:b648753435 . _:b648753444 . _:b648753706 . . _:b648753445 . _:b648753446 . . _:b648753447 . _:b648754181 . _:b648753440 . _:b648753717 . . _:b648753441 . _:b648753442 . _:b648753443 . _:b648753654 . . _:b648753716 . _:b648753452 . _:b648753453 . _:b648753454 . _:b648753455 . _:b648753448 . _:b648753719 . _:b648753449 . _:b648753450 . . . _:b648753451 . _:b648753460 . _:b648753718 . _:b648753461 . _:b648753462 . . _:b648753463 . _:b648753456 . _:b648753713 . _:b648753457 . _:b648753669 "3"^^ . _:b648753458 . _:b648753459 . . . . _:b648754432 . _:b648753712 . . _:b648753468 . . _:b648753668 "3"^^ . _:b648753469 . . _:b648753470 . _:b648753471 . _:b648753464 . _:b648753715 . _:b648753591 . . _:b648753465 . _:b648753671 "3"^^ . _:b648753466 . . _:b648753467 . _:b648753476 . _:b648753714 . _:b648753477 . _:b648753670 "3"^^ . _:b648753478 . _:b648753479 . _:b648753472 . _:b648753725 . . _:b648753665 "3"^^ . . _:b648753473 . . _:b648753474 . 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_:b648753517 . _:b648753672 . _:b648753672 "3"^^ . _:b648753518 . _:b648753519 . _:b648753512 . _:b648753735 . _:b648753418 . _:b648753513 . _:b648753675 "3"^^ . _:b648753514 . _:b648753515 . _:b648753524 . _:b648753734 . _:b648753525 . _:b648753674 "3"^^ . . _:b648753526 . _:b648753527 . _:b648753520 . _:b648753729 . _:b648753521 . _:b648753685 "3"^^ . _:b648753522 . _:b648754204 . _:b648753523 . . _:b648754157 . _:b648753728 . _:b648753532 . _:b648753533 . _:b648753684 "3"^^ . _:b648753534 . _:b648753535 . _:b648753528 . _:b648753731 . _:b648753529 . _:b648753687 "3"^^ . . _:b648753530 . _:b648753531 . _:b648753730 . _:b648753686 "3"^^ . _:b648754136 . _:b648753741 . _:b648753681 "3"^^ . _:b648753740 . _:b648754264 . _:b648753680 "3"^^ . . _:b648754324 . _:b648753743 . _:b648753683 "3"^^ . . _:b648753742 . . _:b648753682 "3"^^ . _:b648753482 . _:b648753737 . _:b648753660 . _:b648753693 "3"^^ . _:b648753550 . _:b648753736 . _:b648753692 "3"^^ . _:b648753675 . _:b648753739 . _:b648753695 "3"^^ . _:b648753738 . _:b648753694 "3"^^ . . _:b648753793 . _:b78101402 "be combined with a wide range of other treatment agents, including immune checkpoint inhibitors and targeted therapies, without resulting in undue toxicities for patients such as have been seen with some other treatment combinations [>>29<<, 30]. Further studies to explore such combinations are warranted." . _:b648753749 . _:b648753949 . _:b648753689 "3"^^ . . _:b648753517 . _:b648753748 . _:b648753688 "3"^^ . _:b648754053 . . _:b648753751 . _:b648753691 "3"^^ . . _:b648753750 . _:b648753690 "3"^^ . _:b648753745 . _:b648753701 "3"^^ . . . _:b78101390 "Other eligibility criteria included Karnofsky Performance Score (KPS) of\u2009\u2265\u200970 [>>20<<], adequate bone marrow, liver, and renal function, life expectancy of\u2009\u2265\u20098\u00A0weeks, no other prior malignancy within the last 5\u00A0years, no active viral infections, and sufficient resected tumor material to produce the autologous vaccine." . _:b648753854 . _:b648753744 . _:b648753700 "3"^^ . _:b648754072 . _:b648753564 . _:b648753747 . _:b648753703 "3"^^ . _:b648753746 . _:b648754375 . _:b648753702 "3"^^ . _:b648754220 . _:b648753554 . _:b648753757 . _:b648753697 "3"^^ . . . _:b648753756 . _:b648753696 "3"^^ . _:b648753759 . _:b648753925 . _:b648753699 "3"^^ . _:b648753758 . _:b648753698 "3"^^ . _:b648753905 . _:b648754292 . . _:b648754051 . _:b648753671 . _:b648753753 . _:b648753709 "3"^^ . _:b648754041 . . . _:b648753752 . _:b648753708 "3"^^ . _:b648753755 . . _:b648753711 "3"^^ . _:b648753754 . _:b648753710 "3"^^ . _:b648753510 . _:b648753765 . . _:b648753705 "3"^^ . _:b648753764 . _:b648753704 "3"^^ . _:b648754435 . . _:b648753767 . _:b648753707 "3"^^ . . _:b648754173 . _:b648753766 . _:b648753706 "3"^^ . . _:b648753761 . _:b648753717 "3"^^ . _:b648753389 . _:b648754433 . _:b648753760 . _:b648754127 . _:b648753716 "3"^^ . . . _:b648753763 . _:b648753932 . . _:b78101382 "Absolute lymphocyte count (ALC) was\u2009>\u2009800\u00A0cells/mm3 in 48.6% of the patients (n\u2009=\u2009161) and was\u2009<\u2009800\u00A0cells/mm3 in 51.4% of patients (n\u2009=\u2009170), a characteristic that has been associated with poor prognosis after radiation [>>23<<]. Patients with radiographic evidence of disease progression at baseline were excluded, as they have also been excluded in other recent trials for newly diagnosed glioblastoma [4, 21, 24].Table" . _:b648753719 "3"^^ . _:b648753707 . . _:b648753954 . _:b648753762 . _:b648753864 . _:b648753718 "3"^^ . _:b648753773 . _:b648753713 "3"^^ . . _:b648753772 . _:b648753712 "3"^^ . _:b648753956 . _:b648753775 . _:b648753929 . _:b648753715 "3"^^ . _:b78101413 . _:b648753774 . _:b648753714 "3"^^ . . _:b648753616 . _:b648754253 . _:b648754202 . _:b648753769 . _:b648753725 "3"^^ . _:b648753431 . _:b648753768 . _:b648753724 "3"^^ . _:b648753725 . _:b648753771 . _:b648753727 "3"^^ . _:b648753770 . _:b648753726 "3"^^ . _:b648753781 . _:b648753721 "3"^^ . _:b648753974 . _:b648753780 . . _:b648753720 "3"^^ . _:b648753783 . _:b648753723 "3"^^ . _:b648753782 . _:b648753722 "3"^^ . _:b648753777 . _:b648754027 . _:b648753733 "3"^^ . _:b648753776 . _:b648753732 "3"^^ . _:b648753779 . _:b648753735 "3"^^ . _:b648753855 . _:b648753778 . _:b648753734 "3"^^ . _:b648753789 . _:b648753729 "3"^^ . _:b648754193 . _:b648753788 . _:b648753728 "3"^^ . _:b648753791 . _:b648753577 . _:b78101403 . _:b648753731 "3"^^ . . . _:b648753790 . _:b648753730 "3"^^ . _:b648753785 . _:b648754021 . _:b648753741 "3"^^ . . _:b648753784 . . _:b648753740 "3"^^ . . _:b648753787 . . _:b648753743 "3"^^ . _:b648753786 . _:b648754339 . _:b648753742 "3"^^ . _:b648753450 . _:b648753797 . _:b648753737 "3"^^ . _:b648753750 . _:b648753796 . _:b648753736 "3"^^ . _:b648754389 . . _:b648753799 . _:b648753739 "3"^^ . . _:b648753798 . . _:b648754381 . _:b648753738 "3"^^ . _:b648753793 . _:b648754349 . _:b648753749 "3"^^ . _:b648753615 . _:b648753792 . _:b648753748 "3"^^ . _:b648754362 . . _:b648753845 . _:b648753795 . . _:b648753751 "3"^^ . . . _:b648753794 . _:b648753750 "3"^^ . _:b648753445 . _:b648754403 . . _:b78101406 "Standard of care (SOC) consists of surgical resection followed by 6\u00A0weeks of daily radiotherapy with concurrent temozolomide, then monthly temozolomide [>>2<<]. Median overall survival (mOS) under this SOC is only 15\u201317\u00A0months [2, 3], and\u2009\u2264\u20095% of patients are alive at 5\u00A0years [3]. Loco-regional therapy with alternating electric fields has recently shown an increase in median PFS (mPFS) to 6.7" . _:b648753805 . _:b648753745 "3"^^ . _:b648753969 . . _:b648753804 . _:b648754205 . _:b648753744 "3"^^ . _:b648754153 . _:b648753807 . _:b648753747 "3"^^ . _:b648753806 . _:b648753746 "3"^^ . _:b648753608 . _:b648753801 . _:b648753757 "3"^^ . . _:b648753800 . _:b648753756 "3"^^ . _:b78101412 . "10.1186%2Fs12967-018-1507-6" . _:b648753803 . _:b648753759 "3"^^ . _:b648753594 . . _:b648754294 . _:b648753802 . _:b648753758 "3"^^ . _:b648753701 . _:b648753919 . _:b648753813 . . _:b648753753 "3"^^ . _:b648754056 . _:b648753812 . _:b648753752 "3"^^ . _:b648754421 . _:b648753815 . _:b648753755 "3"^^ . . _:b648753456 . . _:b648753814 . _:b648753754 "3"^^ . _:b648753809 . . _:b648753765 "3"^^ . . _:b648753808 . _:b648753764 "3"^^ . _:b648754131 . _:b648754097 . . _:b648753811 . _:b648753767 "3"^^ . _:b648753810 . _:b78101412 . _:b648753828 . _:b648753484 . _:b648753766 "3"^^ . _:b648754020 . . _:b648753821 . _:b648753761 "3"^^ . _:b78101397 . . _:b648753820 . _:b648753760 "3"^^ . . . _:b648753732 . _:b648753823 . _:b648753763 "3"^^ . _:b648753822 . _:b648753762 "3"^^ . _:b648754252 . . _:b648753817 . . _:b648753961 . _:b648753773 "3"^^ . _:b648754446 . _:b648753684 . _:b648753816 . . _:b648753772 "3"^^ . . . _:b648753819 . _:b648753775 "3"^^ . _:b648754440 . _:b648754133 . . _:b648753818 . _:b648753774 "3"^^ . _:b648754182 . _:b648753829 . . _:b648753769 "3"^^ . _:b648753973 . . _:b648753828 . _:b78101395 "For example, Stupp et al. reported for their control group an\u00A0mOS of 21.2\u00A0months from randomization in a similar patient population [>>24<<]. The increase in survival in MGMT-methylated patients in the DCVax-L trial raises the possibility of a cooperative effect from the combination of temozolomide chemotherapy and the DCVax-L active immune therapy [17]." . _:b648753520 . _:b648753768 "3"^^ . _:b648753681 . _:b78101390 . _:b648754103 . . _:b648753831 . _:b648753771 "3"^^ . _:b648753830 . . _:b648753770 "3"^^ . . . _:b648753825 . _:b648753781 "3"^^ . . _:b648753824 . . _:b648753780 "3"^^ . _:b648753557 . _:b648753827 . . _:b648753783 "3"^^ . _:b648753386 . . . _:b648753826 . _:b648753782 "3"^^ . _:b648753487 . _:b648754057 . _:b648753837 . . _:b648754000 . _:b648753777 "3"^^ . . _:b648753836 . _:b648754409 . _:b648753776 "3"^^ . . _:b648753839 . _:b648754394 . _:b648753779 "3"^^ . _:b648753838 . _:b648753778 "3"^^ . . _:b648753833 . _:b648753789 "3"^^ . . _:b648753832 . _:b648753788 "3"^^ . . . . _:b648753835 . _:b648753687 . _:b648753791 "3"^^ . . . _:b648753834 . . . . _:b648753790 "3"^^ . _:b648753845 . _:b648753785 "3"^^ . _:b648754228 . _:b648753844 . _:b648754088 . . _:b648753784 "3"^^ . _:b648754003 . _:b648753847 . _:b648753787 "3"^^ . _:b648753846 . _:b648753739 . _:b648753786 "3"^^ . _:b648753841 . . _:b648753797 "3"^^ . _:b648753840 . _:b648753796 "3"^^ . _:b648754387 . _:b648753843 . . _:b648753799 "3"^^ . _:b648753842 . . _:b648753798 "3"^^ . _:b648753853 . _:b648754068 . . _:b648753793 "3"^^ . . _:b648753902 . _:b648753795 . _:b648753852 . _:b648753792 "3"^^ . _:b648753428 . . _:b648753855 . _:b648753795 "3"^^ . . _:b648753854 . _:b648753794 "3"^^ . _:b648754198 . . _:b648753849 . . . _:b648753805 "3"^^ . _:b648753669 . _:b648753848 . _:b648753804 "3"^^ . _:b648754106 . _:b648754379 . . _:b648753851 . . _:b648753807 "3"^^ . . _:b78101379 "results" . . . _:b648753850 . _:b648753806 "3"^^ . . _:b648754227 . _:b648753861 . _:b648753801 "3"^^ . _:b648753516 . _:b648753860 . _:b648753800 "3"^^ . . _:b648753863 . _:b648753892 . _:b648753803 "3"^^ . _:b648753862 . _:b648753802 "3"^^ . . _:b648753857 . _:b648753813 "3"^^ . . _:b648754438 . . _:b648753856 . _:b648753812 "3"^^ . _:b648753412 . _:b78101384 "Patients with radiographic evidence of disease progression at baseline were excluded, as they have also been excluded in other recent trials for newly diagnosed glioblastoma [4, 21, >>24<<].Table" . _:b78101380 "The ITT population (n\u2009=\u2009331) (Table\u00A01) is similar to other recent glioblastoma trials [>>4<<, 21, 24], with 61% males (n\u2009=\u2009202) and 39% females (n\u2009=\u2009129), with 75.2% of the patients\u2009\u2265\u200950\u00A0years of age (range 19\u201373\u00A0years), and median KPS of 90." . _:b78101412 . _:b648753859 . . _:b648753815 "3"^^ . . _:b648754308 . _:b648754077 . _:b648753858 . _:b648754309 . _:b648754191 . _:b648753814 "3"^^ . _:b648754310 . _:b648754311 . _:b648754304 . _:b648754115 . _:b648753869 . . _:b648753809 "3"^^ . _:b648753638 . _:b648754305 . _:b648754306 . _:b648753647 . _:b648754307 . _:b648754316 . _:b648753868 . _:b648754317 . _:b78101382 . _:b648753808 "3"^^ . . _:b648753693 . _:b648754318 . _:b648754319 . _:b648754312 . _:b648753871 . _:b648754313 . _:b648753811 "3"^^ . _:b648753727 . _:b648754314 . _:b78101416 . _:b648754315 . _:b648754324 . _:b648753870 . _:b648754325 . _:b648753810 "3"^^ . _:b648754326 . _:b648754327 . _:b648753959 . . _:b648754320 . _:b648753865 . _:b648754321 . _:b648753821 "3"^^ . _:b648754322 . _:b648754323 . _:b648754436 . _:b648754332 . _:b648753864 . _:b648754333 . _:b648753820 "3"^^ . _:b648754334 . _:b648753473 . _:b648754335 . _:b648754328 . _:b648753867 . _:b648754329 . _:b648753823 "3"^^ . _:b648754330 . _:b648754331 . _:b648753939 . _:b648754340 . _:b648753953 . _:b648753928 . _:b648753866 . _:b648754341 . _:b648753822 "3"^^ . _:b648754342 . _:b648754343 . _:b648754248 . _:b648753881 . . _:b648753877 . _:b648754336 . . . _:b648753817 "3"^^ . _:b648754337 . _:b648754338 . _:b648754339 . . _:b648753876 . _:b648754348 . _:b648754349 . _:b648753816 "3"^^ . _:b648754350 . _:b648754351 . _:b648754344 . _:b648753879 . _:b648754345 . _:b648753819 "3"^^ . _:b648754346 . _:b648754347 . _:b648754356 . _:b648753878 . _:b648754357 . _:b78101388 . _:b648753818 "3"^^ . _:b648753529 . _:b648754358 . _:b648754359 . _:b648754352 . _:b648753873 . _:b648754353 . _:b648753829 "3"^^ . . _:b648753861 . _:b648754354 . _:b648754355 . _:b648754364 . _:b648754415 . _:b648753872 . . _:b648753828 "3"^^ . _:b648754365 . _:b648754366 . _:b648754367 . _:b648754196 . _:b648754360 . _:b648753875 . _:b648754361 . _:b648753831 "3"^^ . _:b648754362 . _:b648754363 . _:b648754372 . _:b648753874 . . _:b648754373 . _:b648753830 "3"^^ . _:b648754374 . _:b648754375 . _:b648753955 . _:b648754368 . _:b648753985 . _:b648753885 . _:b648754369 . _:b648753825 "3"^^ . _:b648754370 . _:b648754371 . _:b648754102 . _:b648754380 . _:b648753884 . _:b648754381 . _:b648754430 . _:b648753824 "3"^^ . _:b648753539 . _:b648754382 . _:b648754383 . . . _:b648753887 . _:b648754376 . _:b648754377 . _:b648753827 "3"^^ . _:b648754378 . . _:b648754379 . _:b648754388 . _:b648753886 . _:b648754389 . _:b648753826 "3"^^ . _:b648753708 . . _:b648754390 . _:b648754391 . _:b648754384 . _:b648753881 . _:b648754385 . _:b648753837 "3"^^ . _:b648754386 . _:b648754387 . _:b648754396 . _:b648753880 . _:b648754397 . _:b648753836 "3"^^ . _:b648754398 . _:b648754399 . . _:b648753883 . _:b648754392 . _:b648754393 . _:b648753839 "3"^^ . . _:b648754394 . . _:b648754395 . _:b648754404 . _:b648753882 . _:b648754405 . _:b648753850 . _:b648753838 "3"^^ . _:b648754406 . _:b648753737 . _:b648754407 . _:b648753595 . _:b648754172 . _:b648753893 . _:b648754400 . _:b648754401 . _:b648753833 "3"^^ . _:b648754402 . _:b648754066 . _:b648753574 . _:b648753982 . _:b648754403 . _:b648754412 . _:b648753892 . . _:b648753832 "3"^^ . _:b648754413 . _:b648754414 . _:b648754415 . . _:b648753895 . _:b648754408 . _:b648754409 . _:b648753835 "3"^^ . _:b648754410 . _:b648754411 . _:b648754420 . _:b648753894 . _:b648754421 . _:b648753834 "3"^^ . _:b648754422 . . _:b648754423 . _:b648754416 . _:b648753889 . _:b78101404 _:b78101405 . _:b648753845 "3"^^ . _:b648754417 . _:b78101404 _:b78101406 . _:b648754418 . _:b78101404 _:b78101407 . _:b648754419 . _:b648754428 . _:b648753888 . _:b648754429 . _:b648753844 "3"^^ . _:b648754430 . . _:b648754431 . _:b648754424 . _:b648753891 . . _:b648753847 "3"^^ . _:b648754425 . _:b648754426 . _:b648754427 . _:b648754180 . _:b648753890 . _:b648753588 . _:b648753846 "3"^^ . _:b648754181 . . _:b648754182 . . _:b648754183 . _:b648754176 . _:b648753901 . _:b648754177 . _:b648753841 "3"^^ . _:b648754178 . _:b648754179 . . _:b78101413 "Dendritic cells (DCs) are central to the immune system as key regulators of immune tolerance and immunity [>>11<<]. For more than a decade, our group and others have been testing active vaccination strategies, such as DCs pulsed with tumor lysates or synthetic peptides to induce antitumor immunity in glioblastoma patients [12, 13]. We have previously" . _:b648753900 . _:b648754188 . _:b648754189 . _:b648754385 . _:b648753840 "3"^^ . _:b648754190 . _:b648754191 . . _:b648753903 . _:b648754184 . _:b648754185 . _:b648754201 . _:b648753999 . _:b648753843 "3"^^ . _:b648754186 . _:b648754187 . _:b648754367 . _:b648754196 . _:b648753902 . . _:b648754197 . _:b648753842 "3"^^ . _:b648754198 . _:b648754199 . _:b648754192 . _:b648753897 . _:b648754193 . _:b648753853 "3"^^ . . _:b648754194 . _:b648754195 . _:b648754204 . _:b648753896 . _:b648754205 . _:b648753852 "3"^^ . _:b648753651 . _:b648754206 . _:b648753414 . _:b648754207 . _:b78101404 _:b78101412 . _:b648753899 . _:b648754200 . _:b78101404 _:b78101413 . _:b648753855 "3"^^ . _:b648753670 . _:b648754201 . _:b78101404 _:b78101414 . _:b648754202 . _:b78101393 _:b78101394 . _:b78101404 _:b78101415 . _:b648754203 . _:b78101393 _:b78101395 . _:b78101404 _:b78101408 . _:b648753898 . _:b648754212 . _:b78101393 _:b78101396 . _:b78101404 _:b78101409 . _:b648753854 "3"^^ . _:b648754213 . _:b78101393 _:b78101397 . _:b78101404 _:b78101410 . _:b648754214 . _:b78101393 _:b78101398 . _:b78101404 _:b78101411 . _:b648754215 . _:b78101393 _:b78101399 . _:b78101393 _:b78101400 . _:b648753909 . _:b648754208 . _:b78101393 _:b78101401 . _:b648753849 "3"^^ . _:b648754209 . . _:b78101393 _:b78101402 . _:b78101392 "The vaccine was aliquoted in individual doses and cryopreserved at\u2009<\u2009150\u00A0\u00B0C [>>22<<]. The doses were stored centrally, and shipped individually to the clinical trial sites." . _:b648754210 . _:b78101393 _:b78101403 . _:b648754211 . _:b78101404 _:b78101416 . _:b648753908 . _:b648754220 . _:b78101404 _:b78101417 . _:b648753848 "3"^^ . _:b648754221 . _:b648754222 . _:b648754223 . _:b648753485 . _:b648753911 . _:b648754216 . _:b78101389 _:b78101392 . _:b648754217 . _:b648753931 . _:b648753851 "3"^^ . _:b648754218 . _:b648754219 . _:b648754188 . . _:b648753910 . _:b648754228 . _:b648754229 . _:b648754100 . _:b648753850 "3"^^ . _:b648753415 . _:b648754230 . _:b648754231 . . _:b648753905 . _:b648753861 "2"^^ . _:b648754224 . _:b648754225 . _:b648754226 . _:b648754227 . . _:b648754236 . _:b648753904 . _:b648753860 "2"^^ . . _:b648754237 . _:b648754238 . _:b648754239 . _:b648754232 . _:b648753907 . _:b648753863 "2"^^ . . _:b648754233 . . _:b648754234 . _:b648754235 . _:b648754244 . _:b648753906 . _:b648753862 "2"^^ . _:b648754245 . _:b648754246 . _:b648754247 . _:b648754240 . _:b648753917 . _:b648753857 "2"^^ . . _:b648754241 . _:b648754242 . _:b648754243 . . _:b648754252 . _:b648753916 . _:b648753856 "2"^^ . _:b648754253 . _:b78101389 _:b78101390 . _:b648754254 . _:b78101389 _:b78101391 . _:b648754255 . _:b78101379 _:b78101384 . _:b648753919 . _:b648753859 "2"^^ . _:b648754248 . _:b78101379 _:b78101385 . _:b648754249 . _:b78101379 _:b78101386 . _:b648754250 . _:b78101379 _:b78101387 . _:b648754251 . _:b78101379 _:b78101388 . _:b648753918 . _:b648753858 "2"^^ . _:b648754260 . . _:b648754261 . _:b648754262 . _:b648754263 . _:b648754256 . _:b648753913 . _:b648753869 "2"^^ . . _:b648754257 . . _:b648754258 . _:b648754259 . _:b78101379 _:b78101380 . _:b648753912 . _:b648753868 "2"^^ . _:b648754268 . _:b78101379 _:b78101381 . _:b648754269 . _:b78101379 _:b78101382 . _:b648754270 . . _:b648754271 . _:b78101379 _:b78101383 . . _:b648753915 . _:b648753871 "2"^^ . _:b648754264 . _:b648754265 . _:b648754266 . _:b648754267 . _:b648754067 . _:b648754276 . _:b648753914 . _:b648753870 "2"^^ . _:b648754277 . _:b648753970 . . _:b648753662 . _:b648754278 . _:b648754279 . _:b648753413 . _:b648753865 "2"^^ . _:b648754272 . _:b648754273 . _:b648754274 . . . _:b648754275 . _:b648753398 . _:b648753412 . _:b648753864 "2"^^ . _:b648754284 . . _:b648754285 . _:b648754286 . _:b648754287 . _:b648753415 . _:b648753867 "2"^^ . _:b648754280 . . _:b648754281 . _:b648754282 . _:b648754283 . _:b648753414 . _:b648753866 "2"^^ . _:b648754292 . _:b648754293 . _:b648754294 . _:b648754295 . _:b648753409 . _:b648753877 "2"^^ . _:b648754288 . _:b648754289 . _:b648754290 . _:b648754291 . _:b648753408 . _:b648753876 "2"^^ . . . _:b648754300 . _:b648754301 . _:b648754302 . _:b648754303 . . _:b648753879 "2"^^ . _:b648754296 . _:b648753411 . _:b648754297 . . _:b648754298 . . _:b648754299 . _:b648753410 . _:b648753878 "2"^^ . _:b648754093 . . _:b648753421 . _:b648753873 "2"^^ . _:b648753406 . _:b648753934 . _:b648753420 . _:b648753872 "2"^^ . . _:b648753423 . _:b648754169 . _:b648753875 "2"^^ . . _:b648753422 . _:b648753888 . _:b648753874 "2"^^ . . _:b648753417 . _:b648753885 "2"^^ . . . _:b648753930 . _:b648753416 . _:b648753884 "2"^^ . . _:b648754376 . _:b648753419 . _:b648753887 "2"^^ . . _:b648753886 "2"^^ . _:b648753418 . _:b648753979 . _:b648753429 . _:b648753881 "2"^^ . . _:b648753428 . _:b648753880 "2"^^ . . . _:b648753431 . _:b648753883 "2"^^ . . _:b648753430 . _:b648753882 "2"^^ . _:b648754225 . . _:b648753893 "2"^^ . _:b648753425 . . . _:b648753637 . _:b648753399 . _:b648753424 . _:b648753892 "2"^^ . . _:b648754174 . _:b648753427 . _:b648753895 "2"^^ . _:b648754382 . _:b648753645 . _:b648753426 . _:b648753894 "2"^^ . . _:b648753437 . _:b648753889 "2"^^ . _:b648753835 . _:b648753436 . _:b648753888 "2"^^ . _:b648753416 . _:b648753439 . _:b648753891 "2"^^ . _:b648754355 . . . . _:b648753438 . _:b648753890 "2"^^ . _:b648754042 . _:b648753433 . _:b648753901 "2"^^ . . _:b648753432 . _:b648754162 . _:b648753900 "2"^^ . _:b78101415 . _:b648753624 . _:b648753435 . _:b648754311 . _:b648753903 "2"^^ . . _:b648754441 . _:b648753997 . _:b648753434 . _:b648754199 . _:b648753902 "2"^^ . _:b648753655 . . _:b648753445 . _:b648753897 "2"^^ . . _:b648753444 . _:b648753896 "2"^^ . . _:b648753465 . _:b648753899 "2"^^ . _:b648753447 . . . _:b648753920 . _:b648753761 . _:b648753446 . _:b648753898 "2"^^ . _:b648753441 . _:b648753909 "2"^^ . _:b648753993 . _:b648753440 . _:b648754145 . _:b648753908 "2"^^ . _:b648753562 . _:b648754022 . _:b648753443 . _:b648753911 "2"^^ . . _:b648753910 "2"^^ . _:b648754436 . _:b648753442 . _:b648754437 . . _:b648753791 . _:b648754438 . _:b648754439 . _:b648753453 . _:b648753905 "2"^^ . _:b648754432 . _:b648754433 . _:b648754434 . _:b648754435 . _:b648754420 . _:b648753452 . _:b648753904 "2"^^ . _:b648754444 . _:b648754445 . _:b648754446 . . _:b648753694 . _:b648754447 . _:b648753455 . _:b648753907 "2"^^ . _:b648754440 . _:b648754441 . _:b648754442 . _:b648753471 . _:b648753607 . _:b648754443 . _:b648753454 . _:b648753906 "2"^^ . _:b648753449 . _:b648753917 "2"^^ . _:b648754448 . . . _:b648754449 . . . _:b648753448 . _:b648753916 "2"^^ . _:b648753451 . _:b648753919 "2"^^ . . _:b648753495 . _:b648753450 . _:b648753918 "2"^^ . _:b648753461 . _:b648753913 "2"^^ . _:b648753736 . _:b648754235 . _:b648753377 . _:b648753912 "2"^^ . _:b648753460 . . _:b648754272 . _:b648753809 . _:b648753463 . _:b648753915 "2"^^ . . _:b648753884 . _:b648753462 . _:b648753914 "2"^^ . _:b648753751 . . _:b648753925 "2"^^ . _:b648753457 . _:b648753395 . _:b648753456 . _:b648753924 "2"^^ . . _:b648754222 . _:b648753459 . _:b648753927 "2"^^ . _:b648753620 . . _:b648753807 . _:b648753458 . _:b648753926 "2"^^ . _:b648754296 . _:b648753469 . _:b648753921 "2"^^ . . . _:b648754332 . . . _:b648753920 "2"^^ . _:b648753468 . _:b648753471 . _:b648754425 . _:b648753923 "2"^^ . . . _:b648753922 "2"^^ . _:b648753470 . _:b648753465 . _:b78101391 "Patients were excluded if they already had apparent early disease progression/recurrence or pseudo-progression at the baseline visit, similar to the inclusion/exclusion criteria of other recent trials in glioblastoma [>>4<<, 21]." . _:b648753933 "2"^^ . _:b648753464 . _:b648753932 "2"^^ . . . _:b648753467 . _:b648753935 "2"^^ . . _:b648753466 . _:b648753934 "2"^^ . _:b648753486 . _:b648753477 . _:b648753929 "2"^^ . _:b648753476 . _:b648753928 "2"^^ . _:b648753479 . _:b648753931 "2"^^ . . _:b648753478 . _:b648753930 "2"^^ . _:b648753774 . _:b648754328 . _:b648753473 . _:b648754366 . _:b648753941 "2"^^ . . . _:b648753472 . _:b648753940 "2"^^ . . _:b648754203 . . _:b648753475 . _:b648753943 "2"^^ . . _:b648753942 "2"^^ . _:b648753474 . _:b648753485 . _:b648753937 "2"^^ . . _:b648754257 . . _:b648753936 "2"^^ . _:b648753484 . . _:b648753801 . _:b648753487 . _:b78101399 . _:b648753939 "2"^^ . _:b648753486 . _:b78101416 . _:b648753938 "2"^^ . _:b648753603 . . . . _:b648753586 . _:b648753481 . _:b648753949 "2"^^ . . _:b648753944 . _:b648753480 . _:b648753948 "2"^^ . _:b648753492 . _:b648753951 "2"^^ . . _:b648753483 . . _:b648753482 . _:b648753950 "2"^^ . _:b648753493 . _:b648753945 "2"^^ . . _:b648753699 . . . _:b648753944 "2"^^ . _:b648753634 . _:b648753492 . _:b78101399 "Thus, it appears that patients who survive past certain threshold time points may continue onwards to unusually long survival times, similar to the findings in our prior Phase I/II studies of this DC-based vaccine [>>17<<\u201319]. Further maturation of the trial data is needed to more fully reveal the extent of the long tail of the survival curve." . _:b648753411 . _:b648753947 "2"^^ . _:b648753495 . _:b648753494 . _:b648753946 "2"^^ . . _:b648753489 . _:b648753957 "2"^^ . _:b648753488 . _:b648753989 . _:b648753956 "2"^^ . _:b648753491 . _:b648753959 "2"^^ . _:b648753490 . _:b648753958 "2"^^ . . _:b648753501 . _:b648753953 "2"^^ . _:b648753598 . . _:b648753952 "2"^^ . _:b648753500 . _:b648753427 . _:b648753503 . _:b648753955 "2"^^ . . _:b648754138 . _:b648753502 . _:b648753954 "2"^^ . . . _:b648753648 . _:b648753497 . _:b648753965 "2"^^ . . _:b648753958 . . _:b648754273 . _:b648754059 . _:b648753496 . _:b648753964 "2"^^ . . . _:b648753967 "2"^^ . _:b648753499 . _:b648754312 . . _:b648753498 . _:b648753966 "2"^^ . . _:b648754231 . _:b648754190 . _:b648753410 . _:b648753509 . _:b648753961 "2"^^ . _:b648753508 . _:b648753960 "2"^^ . _:b648754325 . . _:b648753511 . _:b648753963 "2"^^ . _:b648754262 . _:b648753597 . _:b648753510 . _:b648753962 "2"^^ . . . . _:b648753505 . _:b648753973 "2"^^ . _:b648754356 . _:b648753770 . _:b648753504 . _:b648753972 "2"^^ . _:b648754159 . _:b648753449 . _:b648753880 . _:b648753454 . _:b648753507 . _:b648753975 "2"^^ . . _:b648753506 . _:b648753974 "2"^^ . . _:b648753517 . _:b648753969 "2"^^ . . . _:b648753968 "2"^^ . _:b648753516 . _:b648753826 . _:b648753519 . _:b648753971 "2"^^ . _:b78101386 . _:b648753518 . _:b648753970 "2"^^ . _:b648754390 . . . _:b648753981 "2"^^ . _:b648753513 . . _:b648753512 . _:b648753980 "2"^^ . _:b648753388 . _:b648753515 . _:b648753983 "2"^^ . _:b648753514 . _:b648753982 "2"^^ . . . . _:b648753977 "2"^^ . _:b648753525 . . _:b648753524 . _:b648753976 "2"^^ . . _:b648753527 . _:b648753979 "2"^^ . _:b648753837 . _:b648753373 . _:b648753526 . _:b648753978 "2"^^ . _:b648753633 . . _:b648753814 . _:b648753521 . _:b648753989 "2"^^ . _:b648753652 . . _:b648753520 . _:b648753988 "2"^^ . _:b648753527 . _:b648753755 . _:b648753523 . _:b648753991 "2"^^ . _:b78101406 . _:b648753522 . _:b648753990 "2"^^ . . _:b648754177 . _:b648754039 . _:b648753859 . _:b648754354 . _:b78101407 . . _:b648754283 . _:b648753533 . _:b648753985 "2"^^ . . . _:b648754038 . _:b648753984 "2"^^ . _:b648753532 . . _:b648754308 . _:b648753535 . _:b648753987 "2"^^ . . . _:b648753534 . _:b648753986 "2"^^ . . _:b648753529 . _:b648753997 "2"^^ . . _:b648753528 . _:b648753996 "2"^^ . _:b648754200 . . _:b648753999 "2"^^ . _:b648753506 . _:b648753531 . _:b648753530 . _:b648753998 "2"^^ . . _:b648753541 . _:b648753993 "2"^^ . _:b648754360 . _:b648753540 . _:b648753992 "2"^^ . _:b648753543 . _:b648753995 "2"^^ . _:b648754043 . . _:b648753994 "2"^^ . _:b648753865 . _:b648753542 . . _:b648753552 . _:b648753537 . _:b78101417 . _:b78101416 . _:b648754005 "2"^^ . _:b648753718 . _:b648754187 . _:b648753536 . _:b648754004 "2"^^ . _:b648754211 . _:b78101412 "However, there has been no material advance in survival with systemic therapies since the addition of temozolomide 12\u00A0years ago, despite investigations with many diverse agents [2, >>5<<\u201310]." . _:b648753776 . _:b648754447 . _:b648753382 . _:b648754007 "2"^^ . _:b648753539 . . _:b648753924 . . . _:b648754006 "2"^^ . _:b648753538 . . _:b648753549 . _:b648754001 "2"^^ . . _:b648753548 . _:b648754000 "2"^^ . . _:b648753551 . _:b648754003 "2"^^ . . _:b648753550 . _:b648754101 . _:b648754002 "2"^^ . _:b648753545 . _:b648754414 . _:b648754013 "2"^^ . _:b648753544 . _:b648754012 "2"^^ . . . . _:b648754353 . _:b648753547 . _:b648754015 "2"^^ . _:b648753546 . _:b648754014 "2"^^ . _:b648753557 . _:b648754009 "2"^^ . _:b648753822 . _:b648753556 . _:b648754008 "2"^^ . _:b648753559 . _:b648754011 "2"^^ . . _:b648753558 . _:b648754010 "2"^^ . _:b648754347 . _:b648753553 . _:b648754021 "2"^^ . _:b648753994 . _:b648753552 . _:b648754020 "2"^^ . . _:b648754023 "2"^^ . _:b648753555 . . _:b648753554 . _:b648754022 "2"^^ . _:b648754236 . _:b648753565 . _:b648754017 "2"^^ . . _:b648754246 . _:b648753564 . _:b648754016 "2"^^ . _:b648753792 . _:b648753567 . _:b648754277 . _:b648754019 "2"^^ . _:b648753566 . _:b648754018 "2"^^ . _:b648753759 . . _:b648754029 "2"^^ . _:b648753561 . _:b648753560 . _:b648754028 "2"^^ . _:b648753563 . _:b648754031 "2"^^ . . _:b648753918 . _:b648753562 . _:b648754030 "2"^^ . _:b648753658 . _:b648753573 . _:b648754025 "2"^^ . _:b78101412 . _:b78101412 . _:b648753572 . _:b648754024 "2"^^ . _:b648753803 . . _:b648753575 . _:b648754027 "2"^^ . _:b648753893 . . _:b648753574 . _:b648754026 "2"^^ . _:b648753900 . . _:b648754037 "2"^^ . _:b648753569 . _:b648754226 . . . _:b648754036 "2"^^ . _:b648753568 . _:b648753385 . . _:b648753571 . _:b648754039 "2"^^ . _:b648754323 . . _:b648754038 "2"^^ . _:b648753570 . . _:b648753581 . _:b648754033 "2"^^ . _:b648753842 . . _:b648754032 "2"^^ . _:b648753580 . _:b648753583 . _:b648754035 "2"^^ . _:b648754176 . _:b648753582 . _:b648754034 "2"^^ . . _:b648753990 . _:b648754104 . . _:b648754045 "2"^^ . _:b648753957 . _:b648753577 . . _:b648753499 . . _:b648754364 . _:b648753576 . _:b648754044 "2"^^ . . . _:b648753579 . _:b648754047 "2"^^ . _:b648753820 . _:b648753723 . _:b648753578 . _:b648754046 "2"^^ . . _:b648753589 . _:b648754041 "2"^^ . _:b648753629 . . . _:b648754040 "2"^^ . _:b648753588 . _:b648754085 . _:b648753591 . _:b648754043 "2"^^ . _:b648753921 . _:b648753590 . _:b648754042 "2"^^ . _:b78101411 . . _:b648753585 . _:b648754053 "2"^^ . . _:b648753584 . _:b648754052 "2"^^ . . _:b648754055 "2"^^ . _:b648753587 . . . _:b648754054 "2"^^ . _:b648753586 . . _:b648753730 . _:b648753478 . _:b648753597 . _:b648754049 "2"^^ . _:b648754024 . _:b648753596 . _:b648754048 "2"^^ . . _:b648753599 . _:b648754051 "2"^^ . _:b648754302 . _:b648753935 . _:b648753598 . _:b648754050 "2"^^ . _:b648754091 . . _:b648753593 . _:b648754061 "2"^^ . . _:b648753592 . _:b648754060 "2"^^ . . _:b648753595 . _:b648754063 "2"^^ . . _:b648753594 . _:b648754062 "2"^^ . . . . _:b648754057 "2"^^ . _:b648753605 . . _:b648754306 . _:b648753507 . _:b648754056 "2"^^ . _:b648753604 . . _:b648753607 . _:b648754059 "2"^^ . . . _:b648754058 "2"^^ . _:b648753606 . _:b648754243 . _:b78101385 . _:b648753601 . _:b648754069 "2"^^ . _:b648753728 . _:b648753600 . _:b648754068 "2"^^ . _:b648753603 . _:b648754071 "2"^^ . . _:b648753704 . . _:b648753602 . _:b648754070 "2"^^ . . _:b648753613 . _:b648754065 "2"^^ . _:b648753697 . _:b648753612 . _:b648754064 "2"^^ . . _:b648754067 "2"^^ . _:b648753615 . _:b648754175 . . _:b648754066 "2"^^ . _:b648753614 . . . _:b648753609 . _:b648754077 "2"^^ . . _:b648754076 "2"^^ . _:b648753608 . _:b648753840 . _:b648754279 . _:b648754259 . _:b648753611 . _:b648754079 "2"^^ . _:b648753515 . _:b648754171 . _:b648753610 . _:b648754078 "2"^^ . _:b648753804 . _:b648753644 . . _:b648753525 . _:b648754073 "2"^^ . _:b648753621 . _:b648754238 . . _:b648754300 . _:b648753620 . _:b648754244 . _:b648754072 "2"^^ . _:b648753463 . _:b648753623 . _:b648754075 "2"^^ . . _:b648753622 . _:b648754434 . _:b648754074 "2"^^ . . _:b648753617 . _:b648754085 "2"^^ . _:b648753581 . _:b648753483 . _:b648753546 . _:b648753616 . _:b648754132 . _:b648754084 "2"^^ . _:b648754299 . . _:b648753619 . _:b648754087 "2"^^ . _:b648753420 . . _:b648754086 "2"^^ . . _:b648753618 . _:b648753722 . . _:b648753903 . _:b648753629 . _:b648754081 "2"^^ . _:b648753876 . . _:b648754242 . . _:b648754080 "2"^^ . _:b648753628 . _:b648753391 . _:b648753882 . . _:b648754083 "2"^^ . _:b648753984 . _:b648753631 . _:b648753943 . _:b648754422 . _:b648753630 . _:b648754082 "2"^^ . _:b648754437 . _:b648753625 . _:b648754093 "2"^^ . _:b648754436 . _:b648753624 . _:b648754092 "2"^^ . _:b648754439 . _:b648753786 . _:b648753423 . . _:b648754095 "2"^^ . _:b648753627 . _:b648754438 . _:b648754348 . . _:b648754094 "2"^^ . _:b648753626 . . _:b648754433 . _:b648753637 . _:b648754089 "2"^^ . _:b648754432 . . . _:b648753636 . _:b648754088 "2"^^ . _:b648754435 . _:b648754410 . _:b648753639 . _:b648754091 "2"^^ . _:b648753731 . _:b648754434 . _:b648753464 . _:b648754240 . _:b648753638 . _:b648754233 . _:b648754090 "2"^^ . _:b648753878 . _:b648754445 . _:b648754338 . _:b648753733 . . _:b648754101 "2"^^ . _:b648753633 . _:b648754444 . _:b648753632 . _:b648754100 "2"^^ . . _:b648754447 . . . _:b648753635 . _:b648754103 "2"^^ . _:b648754446 . _:b648753772 . _:b78101415 "For more than a decade, our group and others have been testing active vaccination strategies, such as DCs pulsed with tumor lysates or synthetic peptides to induce antitumor immunity in glioblastoma patients [12, >>13<<]. We have previously demonstrated the effectiveness of DC vaccination in pre-clinical models [14\u201316], and early stage clinical trials have shown substantial promise [17\u201319]." . . . _:b648754102 "2"^^ . _:b648753634 . . . _:b648754441 . _:b648753645 . _:b648754097 "2"^^ . _:b648753551 . _:b648754440 . . . _:b648753602 . _:b648753644 . _:b648754096 "2"^^ . _:b648754443 . _:b648753647 . _:b648754099 "2"^^ . _:b648753869 . _:b648754442 . . . _:b648754098 "2"^^ . _:b648753646 . _:b648753897 . _:b648753839 . _:b648753468 . _:b648754109 "2"^^ . _:b648753641 . . _:b648754108 "2"^^ . _:b648753640 . _:b648753714 . _:b648753535 . _:b648754245 . _:b648754111 "2"^^ . _:b648753643 . . _:b648753599 . _:b648753642 . _:b648754110 "2"^^ . . _:b648754449 . . _:b648753653 . _:b648754105 "2"^^ . _:b648754448 . _:b648754369 . . _:b648754104 "2"^^ . _:b648753652 . _:b648753655 . _:b648754107 "2"^^ . _:b648753513 . . _:b648754395 . _:b648754106 "2"^^ . _:b648753654 . . . _:b648754301 . _:b648754117 "2"^^ . _:b648753649 . . _:b648753640 . _:b648753587 . _:b648753648 . _:b648754116 "2"^^ . _:b648754293 . . _:b648753396 . _:b648754119 "2"^^ . _:b648753651 . . _:b648753436 . . _:b648754427 . _:b648753650 . _:b648754118 "2"^^ . _:b648753661 . _:b648754113 "2"^^ . _:b648754398 . . . _:b648753660 . _:b648754112 "2"^^ . . _:b648753663 . _:b648754115 "2"^^ . . _:b648753662 . _:b648754114 "2"^^ . _:b648753665 . . _:b648753657 . _:b648754125 "2"^^ . _:b648754019 . . _:b648754124 "2"^^ . _:b648753656 . . _:b648753911 . _:b648753605 . _:b648754127 "2"^^ . _:b648753659 . _:b648753658 . _:b648754126 "2"^^ . _:b648754121 "2"^^ . _:b648754120 "2"^^ . _:b648754399 . _:b648754123 "2"^^ . _:b648753571 . _:b648753489 . _:b648754122 "2"^^ . _:b648754335 . _:b648754133 "2"^^ . _:b648753894 . _:b648753764 . _:b648753703 . _:b648753816 . _:b648754132 "2"^^ . . . _:b648754135 "2"^^ . _:b648754134 "2"^^ . _:b648753690 . . _:b648754129 "2"^^ . _:b648754034 . _:b648754128 "2"^^ . _:b78101394 "For example, Weller et al. reported mOS of 17.4\u00A0months from randomization in the ITT population [21], and Stupp et al. reported mOS of 16.0\u00A0months from randomization in the ITT population [>>24<<]." . _:b648754131 "2"^^ . _:b648753988 . . _:b648754130 "2"^^ . _:b648753653 . _:b648753856 . _:b648754141 "2"^^ . _:b648754140 "2"^^ . _:b648753497 . _:b648753794 . _:b648754143 "2"^^ . _:b648754142 "2"^^ . _:b648753441 . . . . _:b648754137 "2"^^ . _:b648754136 "2"^^ . _:b78101414 . _:b648754040 . . _:b648754139 "2"^^ . . _:b648754138 "2"^^ . _:b648754149 "2"^^ . . _:b648753570 . _:b648754148 "2"^^ . . _:b648754151 "2"^^ . _:b648754150 "2"^^ . . . . . _:b648754417 . _:b648754145 "2"^^ . . . . . _:b648754144 "2"^^ . . _:b648754147 "2"^^ . _:b648754149 . _:b648754146 "2"^^ . _:b648754012 . . _:b648754113 . _:b648754157 "2"^^ . . . _:b648754156 "2"^^ . _:b78101393 . _:b78101404 . _:b648754159 "2"^^ . _:b648754158 "2"^^ . _:b648753680 . _:b648754153 "2"^^ . . _:b648754186 . . _:b648754152 "2"^^ . _:b78101379 . . _:b648753397 . _:b648754155 "2"^^ . . _:b78101389 . _:b648753847 . _:b648754154 "2"^^ . _:b648753433 . _:b648753875 . . _:b648753891 . . _:b648754165 "2"^^ . . . _:b648754164 "2"^^ . . _:b648754167 "2"^^ . . . . _:b648754166 "2"^^ . . _:b648753678 . . _:b648754161 "2"^^ . _:b648754256 . _:b648754160 "2"^^ . . . . _:b648754163 "2"^^ . . _:b648754400 . _:b648754162 "2"^^ . . _:b648754173 "2"^^ . _:b648754172 "2"^^ . _:b648754175 "2"^^ . . _:b648753623 . _:b648754174 "2"^^ . _:b78101410 "Loco-regional therapy with alternating electric fields has recently shown an increase in median PFS (mPFS) to 6.7\u00A0months and mOS to 20.9\u00A0months from randomization, respectively [>>4<<]. However, there has been no material advance in survival with systemic therapies since the addition of temozolomide 12\u00A0years ago, despite investigations with many diverse agents [2, 5\u201310]." . _:b648754135 . _:b648753831 . _:b648754169 "2"^^ . . _:b648753378 . _:b648754168 "2"^^ . . _:b648754171 "2"^^ . _:b648754137 . . _:b648754170 "2"^^ . . _:b648754023 . _:b648754185 . _:b648753444 . _:b648754010 . _:b648754267 . _:b78101387 "With immune-based therapies, a key focus is on the tail of the survival curve [>>26<<]. Among the ITT patients with a surgery date\u2009\u2265\u200930\u00A0months prior to the data collection (n = 223), 30% (n = 67) have lived\u2009\u2265\u200930\u00A0months, and their KM-derived mOS estimate is 46.5\u00A0months." . _:b648753375 . _:b648753475 . . _:b648753656 . . . . . _:b648753910 . _:b648753549 . . . _:b648753823 . . . . . . _:b648754383 . _:b648753509 . . . . _:b648753805 . _:b648753663 . _:b78101380 . . _:b648754029 . . . _:b648753426 . . _:b78101381 . . _:b648753575 . _:b648754331 . _:b648754261 . _:b78101382 . _:b648754152 . _:b78101383 . _:b648753998 . _:b648753474 . . . . . _:b78101379 . _:b648754373 . _:b648754026 . . _:b78101388 . _:b648753692 . _:b648753819 . _:b648753400 . _:b648753504 . _:b78101389 . . _:b78101390 . . _:b648753858 . _:b648754411 . _:b78101391 . . _:b648754164 . _:b78101384 . _:b648753887 . _:b78101385 . _:b648753407 . _:b648753403 . _:b648753536 . . _:b78101386 . _:b648754151 . . . _:b78101384 . _:b78101387 . _:b648753659 . _:b648754397 . _:b648754147 . _:b78101396 . _:b78101401 "DCVax-L has shown a benign safety profile in this Phase 3 study, as it has consistently done in prior early stage trials [17, >>19<<], and in a large group of patients treated on a compassionate use basis [28]." . . _:b78101416 "We have previously demonstrated the effectiveness of DC vaccination in pre-clinical models [>>14<<\u201316], and early stage clinical trials have shown substantial promise [17\u201319]." . _:b78101397 . _:b78101400 "DCVax-L has shown a benign safety profile in this Phase 3 study, as it has consistently done in prior early stage trials [>>17<<, 19], and in a large group of patients treated on a compassionate use basis [28]." . _:b648753493 . _:b78101398 . . . _:b78101399 . . _:b648754179 . _:b78101392 . . _:b648754046 . . _:b78101393 . _:b648753705 . _:b78101394 . _:b78101417 "We have previously demonstrated the effectiveness of DC vaccination in pre-clinical models [14\u201316], and early stage clinical trials have shown substantial promise [>>17<<\u201319]." . . . _:b78101395 . _:b648753783 . . _:b78101404 . _:b78101405 . . _:b78101381 . _:b78101406 . _:b648753749 . . _:b648753868 . _:b78101407 . _:b648753904 . _:b648754124 . _:b648754329 . _:b78101400 . _:b648754189 . _:b78101401 . . . . _:b78101402 . . _:b648754265 . _:b648754295 . _:b78101403 . . _:b648754078 . _:b78101412 . . _:b648753747 . _:b78101413 . _:b648753491 . _:b78101414 . . _:b78101415 . . . _:b78101408 . . . _:b78101409 . . . _:b78101410 . _:b648753757 . _:b78101411 . _:b648753528 . . _:b78101395 . _:b648753458 . _:b78101394 . . . _:b648754165 . . . . _:b78101416 . _:b648754330 . _:b78101417 . _:b648754258 . . _:b648753408 . _:b648753618 . _:b648753563 . _:b648754341 . . . . . . . . _:b648753765 . _:b648753533 . _:b648753674 . . _:b648754320 . _:b648753991 . . . . . . _:b648754047 . . _:b648753787 . . . _:b648753898 . _:b648754007 . _:b648754230 . . . _:b648753947 . . _:b78101388 "Following SOC chemoradiotherapy, and before any DCVax-L treatment, lymphopenia was the most common adverse event, occurring in approximately 170 patients (51%) [>>23<<]." . _:b648753729 . _:b648753713 . . _:b648754444 . . . _:b648754121 . _:b648754117 . _:b648753682 . _:b648753512 . _:b648753951 . . _:b648754123 . . . . _:b78101404 "background" . . . . _:b78101380 . . _:b648753980 . . _:b648753691 . . _:b78101383 . . . _:b648753584 . _:b648753374 . _:b648754314 . . _:b648753780 . _:b648753540 . . . _:b648754317 . _:b648753668 . . _:b78101391 . _:b648754448 . . _:b648753384 . . . . _:b648754167 . _:b648753621 . . _:b648753542 . . . . _:b648753392 . . . _:b78101408 "Median overall survival (mOS) under this SOC is only 15\u201317\u00A0months [2, >>3<<], and\u2009\u2264\u20095% of patients are alive at 5\u00A0years [3]." . . . . . . . _:b648754206 . . . _:b648754118 . _:b648753768 . _:b78101410 . . . _:b648754282 . _:b648753851 . _:b648753981 . _:b648753459 . . _:b648754030 . _:b648753746 . _:b648753561 . . _:b648754342 . _:b648754368 . _:b648753612 . . . _:b648754207 . . . _:b648754318 . . _:b648754089 . _:b648753430 . _:b648754033 . _:b648753937 . . _:b648753962 . . _:b648754048 . . . _:b648754229 . . . . _:b648753908 . . . . . _:b648754372 . . _:b648754402 . . . . _:b648754214 . _:b648753628 . . _:b648753971 . . . _:b648754076 . . _:b648753667 . . . _:b648754141 . . _:b648753387 . . . _:b648753870 . _:b648753404 . . _:b648753938 . _:b648754437 . . _:b648754419 . _:b648753916 . . _:b648753639 . _:b78101411 "However, there has been no material advance in survival with systemic therapies since the addition of temozolomide 12\u00A0years ago, despite investigations with many diverse agents [>>2<<, 5\u201310]." . _:b648753844 . . _:b648753373 . _:b648753643 . . . _:b648753413 . _:b648753479 . . . _:b648754384 . _:b648753375 . . . _:b648753374 . _:b648754181 . _:b648753442 . _:b648754180 . _:b648753825 . . . _:b648754183 . _:b648753963 . . _:b648754182 . . _:b648754177 . _:b648754129 . _:b648753381 . . _:b648754176 . . _:b648753380 . _:b648754179 . _:b648753383 . _:b648754178 . _:b648753382 . _:b648754189 . _:b648753377 . _:b648754188 . . _:b648754426 . _:b648753376 . _:b648753975 . _:b648754191 . _:b648754110 . _:b648753379 . _:b648754190 . . _:b648753712 . _:b648753378 . _:b648754185 . . . _:b648753389 . . _:b648754418 . _:b648754184 . _:b648753860 . _:b648753388 . . _:b648754187 . _:b648753877 . _:b648753391 . _:b648754109 . _:b648753381 . _:b648754186 . . _:b648753390 . _:b648754197 . . _:b648753385 . _:b648754196 . _:b648753384 . _:b648754199 . _:b648753824 . _:b648753387 . _:b648754210 . _:b648754198 . _:b648754150 . _:b648753386 . _:b648754193 . . _:b648754234 . _:b648754116 . . _:b648753397 . . _:b648754192 . _:b648754358 . . . _:b648753396 . _:b648753812 . . _:b648754195 . . _:b648753399 . _:b648753769 . _:b648754194 . _:b648753398 . . _:b648754205 . _:b648753393 . . _:b648754204 . _:b648753373 "36"^^ . _:b648753392 . _:b648753885 . _:b648754142 . _:b648754207 . _:b648753821 . _:b648754241 . _:b648753395 . _:b648754218 . _:b648753374 "30"^^ . _:b648754206 . . _:b648753394 . _:b648754201 . . _:b648753405 . _:b648754200 . . _:b648753404 . _:b648754203 . _:b648754184 . _:b648754412 . _:b648753407 . _:b648754202 . . _:b648753406 . _:b648754309 . . _:b648754213 . _:b648753401 . . _:b648754212 . _:b648753400 . _:b648754215 . . _:b648753403 . . _:b648754214 . _:b648753402 . . _:b648754209 . . . _:b648754208 . . _:b648754211 . . _:b648753688 . _:b648754210 . . _:b648754377 . . _:b648754221 . . _:b648754220 . _:b78101389 "methods" . _:b648754223 . _:b648754222 . _:b648754217 . _:b648753650 . . . _:b648753767 . _:b648754216 . _:b648753948 . _:b648753524 . . . _:b648754219 . _:b648754218 . . _:b648754229 . _:b648753455 . . _:b648754228 . _:b648754231 . . _:b648753719 . _:b648754230 . . _:b648754181 "2"^^ . _:b648754225 . . _:b648754180 "2"^^ . _:b648754224 . . _:b648754183 "2"^^ . _:b648754227 . . _:b648753632 . _:b648754226 . _:b648754182 "2"^^ . _:b648753375 "21"^^ . _:b648754177 "2"^^ . _:b648754237 . . _:b648754236 . _:b648754176 "2"^^ . _:b648753377 "19"^^ . . _:b648753995 . _:b648754239 . _:b648754179 "2"^^ . _:b648753376 "20"^^ . _:b648754178 "2"^^ . _:b648754238 . _:b648753378 "17"^^ . _:b648753866 . _:b648754189 "2"^^ . _:b648754233 . _:b648753379 "17"^^ . . _:b648754232 . _:b648754188 "2"^^ . _:b648753380 "17"^^ . . _:b648754235 . _:b648754191 "2"^^ . _:b648753381 "16"^^ . _:b648753790 . . _:b648753382 "15"^^ . _:b648754234 . _:b648754190 "2"^^ . _:b648753558 . _:b648754271 . _:b648753383 "14"^^ . _:b648754185 "2"^^ . _:b648754245 . _:b648753523 . _:b648754278 . _:b648753384 "14"^^ . _:b648754184 "2"^^ . _:b648754244 . . _:b648753391 "13"^^ . _:b648753385 "14"^^ . _:b648754187 "2"^^ . _:b648754247 . _:b648753390 "13"^^ . _:b648753386 "14"^^ . _:b648754186 "2"^^ . _:b648754246 . . . . _:b648753387 "14"^^ . _:b648754197 "2"^^ . _:b648754241 . . _:b648753388 "14"^^ . _:b648754196 "2"^^ . _:b648754240 . _:b648753501 . _:b648753389 "14"^^ . _:b648754199 "2"^^ . _:b648754243 . _:b648754322 . _:b648753889 . _:b648754198 "2"^^ . _:b648754242 . _:b648753926 . . _:b648754429 . _:b648754253 . _:b648754193 "2"^^ . _:b648753399 "11"^^ . _:b648754252 . _:b648754192 "2"^^ . . . _:b648754255 . _:b648754195 "2"^^ . _:b648753398 "11"^^ . _:b78101385 "In multiple reported studies, neither bevacizumab nor CCNU have been shown to extend survival [>>9<<, 25]." . _:b648753397 "11"^^ . _:b648754254 . _:b648754194 "2"^^ . _:b648753810 . _:b648753754 . _:b648754154 . _:b648754205 "2"^^ . _:b648754249 . _:b648753396 "12"^^ . _:b648754095 . _:b648753452 . _:b648754248 . _:b648754204 "2"^^ . _:b648753395 "12"^^ . _:b648754207 "2"^^ . _:b648754251 . _:b648753394 "12"^^ . _:b648754206 "2"^^ . _:b648754250 . . _:b648754031 . _:b648753393 "12"^^ . _:b648754015 . _:b648754081 . . _:b648754261 . _:b648754201 "2"^^ . . _:b648754359 . _:b648753392 "12"^^ . . _:b648753522 . _:b648754406 . _:b648753407 "10"^^ . . _:b648754260 . _:b648754200 "2"^^ . _:b648753406 "10"^^ . _:b648754203 "2"^^ . _:b648754263 . _:b648753405 "10"^^ . _:b648754202 "2"^^ . _:b648754262 . _:b648754208 . . _:b648753404 "10"^^ . _:b648754213 "2"^^ . _:b648754257 . . . _:b648753403 "10"^^ . . _:b648754256 . _:b648754212 "2"^^ . . _:b648753443 . _:b648753402 "11"^^ . _:b648754259 . _:b648754215 "2"^^ . . _:b648753401 "11"^^ . _:b648754258 . _:b648754214 "2"^^ . . _:b648753853 . _:b648753400 "11"^^ . _:b648754269 . _:b648754209 "2"^^ . _:b648753500 . . _:b648753481 . _:b648754423 . _:b648754208 "2"^^ . _:b648754268 . _:b648754011 . _:b648753414 "9"^^ . _:b648753766 . _:b648754211 "2"^^ . _:b648754271 . _:b648753415 "9"^^ . . _:b648754210 "2"^^ . _:b648754270 . . _:b648753412 "9"^^ . _:b78101407 "Median overall survival (mOS) under this SOC is only 15\u201317\u00A0months [>>2<<, 3], and\u2009\u2264\u20095% of patients are alive at 5\u00A0years [3]." . . _:b648754221 "2"^^ . _:b648754265 . _:b648754365 . _:b648753413 "9"^^ . _:b648754220 "2"^^ . _:b648754264 . _:b648753410 "10"^^ . _:b648754223 "2"^^ . _:b648754267 . . _:b648754443 . _:b648753411 "9"^^ . _:b648753409 "10"^^ . . _:b648754266 . _:b648754222 "2"^^ . . . _:b648753408 "10"^^ . _:b648753721 . _:b648754277 . _:b648754217 "2"^^ . . _:b648754276 . _:b648754216 "2"^^ . _:b648753641 . _:b648753422 "8"^^ . _:b648754054 . _:b648754219 "2"^^ . _:b648754279 . _:b648753423 "8"^^ . . _:b648754218 "2"^^ . _:b648754278 . _:b648753420 "9"^^ . . _:b648754229 "2"^^ . _:b648754273 . _:b648753405 . _:b648753421 "9"^^ . _:b648754228 "2"^^ . _:b648754272 . _:b648753418 "9"^^ . _:b648754231 "2"^^ . _:b648754275 . . _:b648753419 "9"^^ . . _:b648754274 . _:b648754230 "2"^^ . _:b648753519 . _:b648753416 "9"^^ . _:b78101405 . _:b648754225 "2"^^ . _:b648754285 . _:b648753417 "9"^^ . _:b648753585 . _:b648754224 "2"^^ . _:b648754284 . _:b648753430 "8"^^ . _:b648753836 . . _:b648753614 . _:b648754287 . _:b648754227 "2"^^ . _:b648753431 "8"^^ . _:b78101392 . . _:b648754286 . _:b648754226 "2"^^ . . _:b648753428 "8"^^ . _:b648754361 . _:b648754237 "2"^^ . _:b648754281 . . _:b648753429 "8"^^ . _:b648754236 "2"^^ . _:b648754280 . _:b648753426 "8"^^ . _:b648753698 . _:b648754016 . _:b648754239 "2"^^ . _:b648754283 . _:b648753427 "8"^^ . . _:b648753773 . . _:b648754238 "2"^^ . _:b648754282 . _:b648753424 "8"^^ . _:b648754233 "2"^^ . _:b648754293 . _:b648753425 "8"^^ . _:b648753438 "7"^^ . _:b648754292 . _:b648754232 "2"^^ . . _:b648753439 "7"^^ . _:b648754295 . _:b648754235 "2"^^ . . . _:b648754234 "2"^^ . _:b648754294 . . _:b648753436 "8"^^ . _:b648753498 . _:b648754245 "2"^^ . _:b648754289 . . _:b648753437 "8"^^ . _:b648754244 "2"^^ . _:b648754288 . _:b648753434 "8"^^ . . . _:b648754298 . _:b648754247 "2"^^ . _:b648754291 . . . _:b648753435 "8"^^ . _:b648754303 . . _:b648754290 . _:b648754246 "2"^^ . _:b648753432 "8"^^ . _:b648754241 "2"^^ . _:b648754301 . _:b648753433 "8"^^ . . _:b648753446 "7"^^ . _:b648754300 . _:b648754240 "2"^^ . _:b648753447 "7"^^ . _:b648754303 . _:b648754243 "2"^^ . . _:b648753871 . . _:b648754302 . _:b648754242 "2"^^ . _:b648753444 "7"^^ . . . . . . _:b648753445 "7"^^ . _:b648754297 . _:b648754253 "2"^^ . _:b648753685 . . _:b78101383 "Patients with radiographic evidence of disease progression at baseline were excluded, as they have also been excluded in other recent trials for newly diagnosed glioblastoma [>>4<<, 21, 24].Table" . _:b648754296 . _:b648754252 "2"^^ . _:b648753442 "7"^^ . _:b648753443 "7"^^ . _:b648754299 . _:b648754255 "2"^^ . _:b648753976 . . _:b648753440 "7"^^ . _:b648754298 . _:b648754254 "2"^^ . _:b648753572 . . _:b648753441 "7"^^ . _:b648754309 . _:b648754249 "2"^^ . _:b648753454 "7"^^ . _:b648754308 . _:b648754248 "2"^^ . _:b648753906 . _:b648754143 . . _:b648754311 . _:b648754251 "2"^^ . _:b648753455 "7"^^ . _:b648753452 "7"^^ . _:b648754310 . _:b648754250 "2"^^ . . _:b648754108 . _:b648753453 "7"^^ . _:b648754305 . _:b648754261 "2"^^ . . _:b648753450 "7"^^ . _:b648754304 . _:b648754260 "2"^^ . . _:b648754319 . . _:b648754307 . _:b648754281 . _:b648754263 "2"^^ . _:b648754017 . _:b648753451 "7"^^ . . _:b648753789 . _:b648753508 . _:b648754306 . _:b648754262 "2"^^ . _:b648753448 "7"^^ . _:b648754213 . _:b648753543 . _:b648753449 "7"^^ . _:b648754317 . _:b648754257 "2"^^ . _:b648753514 . _:b648753462 "6"^^ . _:b648754256 "2"^^ . _:b648754316 . _:b648754074 . _:b648753463 "6"^^ . _:b648753716 . _:b648753788 . _:b648754343 . _:b648754319 . _:b648754259 "2"^^ . _:b648753817 . _:b648754209 . _:b648753462 . _:b648753965 . _:b648753460 "7"^^ . _:b648754318 . _:b648754258 "2"^^ . _:b648754166 . _:b648753461 "7"^^ . _:b648754313 . _:b648754269 "2"^^ . _:b648753927 . _:b648753578 . . _:b648753458 "7"^^ . _:b648754312 . _:b648754268 "2"^^ . _:b648753568 . _:b648753459 "7"^^ . _:b648754315 . _:b648754271 "2"^^ . _:b648753437 . _:b648754314 . _:b648754270 "2"^^ . _:b648753456 "7"^^ . _:b648753518 . _:b648754064 . _:b648753457 "7"^^ . _:b648754325 . _:b648754265 "2"^^ . _:b648753470 "6"^^ . _:b648754264 "2"^^ . _:b648754324 . . . _:b648753471 "6"^^ . _:b648754267 "2"^^ . _:b648754327 . _:b648753538 . _:b648753468 "6"^^ . _:b648754266 "2"^^ . _:b648754326 . _:b648754219 . _:b648754378 . _:b648753469 "6"^^ . _:b648754291 . _:b648754277 "2"^^ . _:b648754321 . _:b78101409 "Median overall survival (mOS) under this SOC is only 15\u201317\u00A0months [2, 3], and\u2009\u2264\u20095% of patients are alive at 5\u00A0years [>>3<<]. Loco-regional therapy with alternating electric fields has recently shown an increase in median PFS (mPFS) to 6.7\u00A0months and mOS to 20.9\u00A0months from randomization, respectively [4]. However, there has been no material advance in" . . _:b648753466 "6"^^ . _:b648754276 "2"^^ . _:b648754320 . _:b648753467 "6"^^ . _:b648754279 "2"^^ . _:b648754323 . . _:b648753834 . . _:b648753464 "6"^^ . . _:b648754322 . _:b648754278 "2"^^ . . _:b648753446 . _:b648753465 "6"^^ . _:b648754273 "2"^^ . _:b648754333 . _:b648753580 . _:b648753478 "6"^^ . . _:b648754332 . _:b648754272 "2"^^ . . _:b648754442 . _:b648753479 "6"^^ . _:b648753710 . _:b648754275 "2"^^ . _:b648754335 . . _:b648753476 "6"^^ . _:b648754274 "2"^^ . _:b648754334 . _:b648753477 "6"^^ . _:b648754285 "2"^^ . _:b648754329 . _:b648754268 . _:b648754388 . _:b648753541 . _:b648753474 "6"^^ . _:b648754284 "2"^^ . _:b648754328 . _:b648753475 "6"^^ . _:b648753752 . _:b648754287 "2"^^ . _:b648754331 . _:b648754139 . _:b648753472 "6"^^ . . _:b648754330 . _:b648754286 "2"^^ . . . _:b648754144 . _:b648753473 "6"^^ . _:b648754281 "2"^^ . _:b648754341 . _:b648753488 . _:b648753486 "6"^^ . _:b648754280 "2"^^ . _:b648754340 . _:b648754449 . _:b648754099 . _:b648753487 "6"^^ . _:b648754283 "2"^^ . _:b648754343 . _:b648754192 . _:b648753484 "6"^^ . _:b648753996 . . _:b648754342 . _:b648754282 "2"^^ . . _:b648753485 "6"^^ . _:b648754293 "2"^^ . _:b648754337 . . _:b648753482 "6"^^ . _:b648754292 "2"^^ . _:b648754336 . _:b648753483 "6"^^ . _:b648754084 . _:b648754295 "2"^^ . _:b648754339 . _:b648753480 "6"^^ . . _:b648754338 . _:b648754294 "2"^^ . . _:b648753481 "6"^^ . _:b648754289 "2"^^ . _:b648754349 . _:b648754288 "2"^^ . _:b648754348 . _:b648753493 "5"^^ . . . _:b648753779 . _:b648754351 . _:b648754291 "2"^^ . _:b648753492 "5"^^ . _:b648754290 "2"^^ . _:b648754350 . . _:b78101397 "It will be collected and analyzed later, but is unlikely to explain the overall survival results, as the mutation associated with prolonged survival occurs in less than 10% of newly diagnosed glioblastoma patients [>>27<<]." . _:b648753495 "5"^^ . . _:b648754345 . _:b648754301 "2"^^ . _:b648753494 "5"^^ . _:b648754300 "2"^^ . _:b648754344 . . _:b648753709 . _:b648753763 . _:b648754347 . _:b648754303 "2"^^ . . _:b648753740 . _:b648754276 . _:b648753488 "6"^^ . _:b648753758 . _:b648754346 . _:b648754302 "2"^^ . _:b648753491 "5"^^ . . _:b648753489 "6"^^ . . . _:b648754357 . _:b648754297 "2"^^ . . _:b648753490 "5"^^ . _:b648753702 . _:b78101409 . _:b648754296 "2"^^ . _:b648754356 . . _:b648754070 . . _:b648753501 "5"^^ . _:b78101408 . _:b648754299 "2"^^ . _:b648754359 . _:b648753849 . _:b648753500 "5"^^ . _:b648754263 . . _:b648754358 . _:b648754298 "2"^^ . _:b648753503 "5"^^ . _:b648753796 . _:b648753649 . _:b648754353 . _:b648754309 "2"^^ . _:b648753502 "5"^^ . _:b648754284 . _:b648754352 . _:b648754308 "2"^^ . _:b648753646 . _:b648753497 "5"^^ . _:b648754297 . . _:b648754355 . _:b648754311 "2"^^ . . _:b648754128 . _:b648753496 "5"^^ . _:b648754310 "2"^^ . _:b648754354 . _:b648753499 "5"^^ . . _:b648754365 . _:b648754305 "2"^^ . _:b648753498 "5"^^ . . _:b648754364 . _:b648754304 "2"^^ . _:b648753509 "5"^^ . _:b648754168 . _:b648754307 "2"^^ . _:b648754367 . _:b648754315 . . _:b648753508 "5"^^ . _:b648754306 "2"^^ . _:b648754366 . _:b648754424 . _:b648753511 "5"^^ . . _:b648753438 . _:b648754361 . _:b648754317 "2"^^ . . . _:b648753510 "5"^^ . . _:b648754360 . _:b648754316 "2"^^ . _:b648753505 "5"^^ . . _:b648754319 "2"^^ . _:b648754363 . . _:b648753619 . . _:b648753504 "5"^^ . . . _:b648754318 "2"^^ . _:b648754362 . . _:b648753507 "5"^^ . _:b648754055 . _:b648754313 "2"^^ . _:b648754373 . _:b648753742 . _:b648753506 "5"^^ . _:b648754312 "2"^^ . _:b648754372 . _:b648753517 "5"^^ . _:b648754315 "2"^^ . _:b648754375 . _:b648754250 . _:b648753516 "5"^^ . . _:b648754314 "2"^^ . _:b648754374 . . _:b648753519 "5"^^ . _:b648753457 . _:b648754325 "2"^^ . _:b648754369 . _:b648753518 "5"^^ . _:b648754324 "2"^^ . _:b648754368 . _:b648753513 "5"^^ . _:b648754327 "2"^^ . _:b648754371 . . _:b648753734 . _:b648753512 "5"^^ . _:b648754180 . _:b648753592 . _:b648754326 "2"^^ . _:b648754370 . _:b648753515 "5"^^ . _:b648753863 . _:b648754195 . _:b648754321 "2"^^ . _:b648754381 . _:b648753447 . _:b648753514 "5"^^ . . _:b648754345 . _:b648754320 "2"^^ . _:b648754380 . _:b648753525 "5"^^ . _:b648753421 . _:b648754383 . _:b648754323 "2"^^ . _:b648753524 "5"^^ . . _:b648754322 "2"^^ . _:b648754382 . _:b648753527 "5"^^ . _:b648754096 . _:b648754254 . _:b648754333 "2"^^ . _:b648754377 . _:b648753526 "5"^^ . _:b648754332 "2"^^ . _:b648754376 . _:b648753521 "5"^^ . . _:b648753711 . _:b648754335 "2"^^ . _:b648754379 . _:b648754217 . _:b648753402 . _:b648754223 . _:b648753520 "5"^^ . _:b648754334 "2"^^ . _:b648754378 . _:b648753523 "5"^^ . _:b648754329 "2"^^ . _:b648754389 . _:b648753522 "5"^^ . _:b648753636 . . . _:b648754328 "2"^^ . _:b648754388 . . _:b648753533 "5"^^ . _:b648754331 "2"^^ . _:b648754391 . _:b648753532 "5"^^ . _:b648754330 "2"^^ . _:b648754390 . . _:b648753535 "4"^^ . _:b648754270 . _:b648754385 . _:b648754371 . _:b648754341 "2"^^ . _:b648754090 . . _:b648753534 "5"^^ . _:b648754340 "2"^^ . _:b648754384 . _:b648754350 . . _:b648753529 "5"^^ . _:b648754343 "2"^^ . _:b648754387 . _:b648753528 "5"^^ . _:b648754342 "2"^^ . _:b648754386 . _:b648753531 "5"^^ . _:b648754337 "2"^^ . _:b648754397 . . _:b648753748 . _:b648753530 "5"^^ . _:b648754013 . _:b648754396 . _:b648754336 "2"^^ . _:b648753541 "4"^^ . . . . . _:b648754399 . _:b648754339 "2"^^ . _:b648754073 . . _:b648754305 . _:b648753540 "4"^^ . _:b648753832 . _:b648754398 . _:b648754338 "2"^^ . _:b648753543 "4"^^ . . _:b648753775 . _:b648754349 "2"^^ . _:b648754393 . _:b648753542 "4"^^ . . _:b648754348 "2"^^ . _:b648754392 . _:b648753537 "4"^^ . _:b648753579 . _:b648754008 . _:b648754351 "2"^^ . _:b648754395 . _:b648753536 "4"^^ . . . _:b648754394 . _:b648754350 "2"^^ . _:b648753539 "4"^^ . . . _:b648754405 . _:b648754345 "2"^^ . _:b648753538 "4"^^ . _:b648753745 . _:b648754344 "2"^^ . _:b648754404 . _:b648753549 "4"^^ . . _:b648754347 "2"^^ . _:b648754407 . _:b648753548 "4"^^ . . _:b648754346 "2"^^ . _:b648754406 . _:b648753551 "4"^^ . _:b648754357 "2"^^ . _:b648754401 . _:b648753550 "4"^^ . _:b648754071 . _:b648753677 . _:b648754400 . _:b648754356 "2"^^ . _:b648753545 "4"^^ . _:b648754359 "2"^^ . _:b648754403 . _:b648753544 "4"^^ . _:b648753664 . . _:b78101402 . _:b648754358 "2"^^ . _:b648754402 . _:b648753547 "4"^^ . _:b648753706 . . _:b648754316 . . _:b648754413 . _:b648754353 "2"^^ . _:b648753434 . _:b648753546 "4"^^ . . _:b648753630 . . . _:b648754412 . _:b648754352 "2"^^ . . _:b648753557 "4"^^ . _:b648753696 . _:b648754215 . _:b648754415 . _:b648754355 "2"^^ . _:b648754260 . . _:b648753556 "4"^^ . . _:b648754354 "2"^^ . _:b648754414 . _:b648753559 "4"^^ . . _:b648754148 . _:b648754409 . _:b648754365 "2"^^ . _:b648753558 "4"^^ . _:b648753917 . _:b648754364 "2"^^ . _:b648754408 . _:b648753553 "4"^^ . . _:b648754367 "2"^^ . _:b648754411 . _:b648753552 "4"^^ . _:b648754366 "2"^^ . _:b648754410 . _:b648753555 "4"^^ . . . _:b648754421 . _:b648754361 "2"^^ . _:b648753554 "4"^^ . . _:b648754360 "2"^^ . _:b648754420 . _:b648753545 . _:b648753565 "4"^^ . _:b648754363 "2"^^ . _:b648754423 . . _:b648753564 "4"^^ . . _:b648754362 "2"^^ . _:b648754422 . _:b648753567 "4"^^ . . . _:b648754373 "2"^^ . _:b648754417 . _:b648753566 "4"^^ . . . _:b648753521 . _:b648753715 . _:b648754416 . _:b648754372 "2"^^ . _:b648754287 . _:b648753561 "4"^^ . . . _:b648754375 "2"^^ . _:b648754419 . _:b648753560 "4"^^ . _:b648754374 "2"^^ . _:b648754418 . _:b648753563 "4"^^ . _:b648754369 "2"^^ . _:b648754429 . _:b648753562 "4"^^ . _:b648753435 . . _:b648754428 . _:b648754368 "2"^^ . _:b648753573 "4"^^ . _:b648754371 "2"^^ . _:b648754431 . _:b648753572 "4"^^ . _:b648754156 . . _:b648754430 . _:b648754370 "2"^^ . _:b648754158 . _:b648753575 "4"^^ . _:b648753936 . . _:b78101396 . _:b648754381 "2"^^ . _:b648754425 . _:b648753574 "4"^^ . _:b78101399 . . _:b648754424 . _:b648754380 "2"^^ . . _:b648753569 "4"^^ . _:b648754161 . . _:b648754383 "2"^^ . _:b648754427 . _:b648753568 "4"^^ . . _:b648753857 . _:b648754426 . _:b648754382 "2"^^ . _:b648754045 . _:b648754025 . _:b648753571 "4"^^ . .