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_:b215627631 . _:b215627624 . _:b215627444 . . _:b215627615 "2"^^ . _:b215627576 . . _:b215627625 . _:b215627626 . _:b215626456 . _:b215627627 . . _:b215627447 . _:b215627540 . _:b215627541 . _:b215627614 "2"^^ . _:b215627542 . _:b215627252 . _:b215627543 . _:b215627536 . _:b215627446 . _:b215627537 . _:b215627609 "2"^^ . . _:b215627538 . _:b215627539 . _:b116042 . . _:b215627441 . _:b215627548 . _:b215627549 . _:b215627608 "2"^^ . _:b215627550 . _:b215627551 . _:b215627544 . _:b215627440 . _:b215627545 . _:b215627611 "2"^^ . _:b215627546 . _:b215627547 . _:b215626438 . . _:b215627443 . _:b215626603 . _:b215627524 . . _:b215627525 . _:b215627610 "2"^^ . _:b215627526 . _:b215627527 . _:b215627520 . _:b215627442 . . _:b215627621 "2"^^ . _:b215627521 . _:b215627522 . _:b215625987 . _:b215627523 . . _:b215627453 . _:b215627378 . _:b215627191 . _:b215627532 . _:b215627533 . _:b215627620 "2"^^ . _:b215626169 . . . _:b215627534 . _:b215627535 . _:b215626471 . . _:b215627452 . _:b215627528 . _:b215627529 . _:b215627623 "2"^^ . _:b215627530 . _:b215627531 . _:b215627572 . _:b215627455 . _:b215627573 . _:b215627622 "2"^^ . _:b215627574 . _:b215627575 . . _:b215627454 . _:b215627568 . _:b215627569 . _:b215627617 "2"^^ . _:b215626773 . _:b215627570 . _:b215627571 . _:b215627580 . _:b215627449 . _:b215627581 . _:b215627616 "2"^^ . _:b215627582 . _:b215627075 . _:b215627583 . _:b215627576 . _:b215627448 . . _:b215627619 "2"^^ . _:b215627577 . . _:b215626566 . _:b215627578 . _:b215627579 . _:b215627601 . _:b215627556 . _:b215627451 . _:b215627557 . _:b215627618 "2"^^ . _:b215627277 . _:b215627558 . _:b215627559 . _:b215627552 . _:b215627450 . _:b215626520 . _:b215627629 "2"^^ . _:b215627553 . _:b215627554 . _:b215627555 . _:b215627564 . _:b215627461 . _:b215627565 . _:b215627628 "2"^^ . _:b215627566 . _:b215627567 . _:b215625859 . _:b215627560 . _:b215627460 . _:b215627561 . _:b215627631 "2"^^ . . _:b215627562 . _:b215626396 . _:b215626023 . _:b215627563 . _:b215627732 . _:b215627463 . . _:b215627733 . _:b215627630 "2"^^ . . _:b215627734 . _:b215627735 . _:b215626717 . _:b215627728 . _:b215627462 . . _:b215627625 "2"^^ . _:b215626676 . _:b215627729 . _:b215625971 . _:b215627730 . _:b215627731 . _:b215627740 . _:b215627457 . _:b215627741 . _:b215627624 "2"^^ . _:b215627742 . _:b215627743 . . _:b215627456 . _:b215627736 . _:b215627737 . _:b215627627 "2"^^ . _:b215627738 . _:b215627739 . _:b215627716 . _:b215627459 . _:b215627717 . _:b215627626 "2"^^ . _:b215627718 . _:b215625966 . _:b215627719 . _:b215627712 . _:b215627458 . _:b215627713 . _:b215627637 "2"^^ . . _:b215627714 . _:b215627715 . . _:b215627469 . _:b215627724 . _:b215627725 . _:b215627636 "2"^^ . _:b215627726 . _:b215627059 . _:b215627727 . _:b215626408 . _:b215627468 . _:b215627720 . _:b215626518 . _:b215627721 . _:b215627639 "2"^^ . _:b215627722 . _:b215627723 . _:b215627471 . _:b215627638 "2"^^ . _:b215627296 . _:b215627470 . _:b215626022 . _:b215627633 "2"^^ . . . . _:b215627465 . . _:b215627632 "2"^^ . _:b215626388 . _:b215627464 . _:b215627635 "2"^^ . _:b215627366 . _:b215627748 . _:b215627467 . _:b215627749 . _:b215627634 "2"^^ . . _:b215626191 . _:b215626838 . _:b215627744 . _:b215627466 . _:b215627745 . _:b215627645 "2"^^ . _:b215627746 . _:b215627747 . _:b215627477 . . _:b215627644 "2"^^ . _:b215626160 . . _:b215627476 . _:b215626439 . _:b215627647 "2"^^ . _:b215627668 . _:b215627479 . _:b215625893 . _:b215627646 "2"^^ . . _:b215627669 . _:b215627670 . _:b215627671 . . . _:b215627478 . _:b215627664 . . _:b215627665 . _:b215627641 "2"^^ . . _:b215627666 . . _:b215627667 . _:b215627676 . _:b215627473 . _:b215627677 . _:b215627640 "2"^^ . _:b215627678 . _:b215627679 . _:b215626094 . _:b215627472 . _:b215627672 . _:b215627673 . _:b215627643 "2"^^ . _:b215627674 . . _:b215627675 . _:b215627652 . _:b215627475 . _:b215627653 . _:b215627642 "2"^^ . _:b215626069 . _:b215627654 . _:b215627655 . _:b215627648 . _:b215627474 . _:b215627649 . _:b215627653 "2"^^ . _:b215627650 . _:b215626370 . . _:b215627651 . _:b215627660 . _:b215627485 . _:b215627661 . _:b215627652 "2"^^ . . _:b215627662 . _:b215627663 . _:b215627656 . _:b215627484 . _:b215627657 . _:b215627655 "2"^^ . _:b215626352 . _:b215627658 . _:b215627659 . _:b215627700 . _:b215627487 . _:b215627701 . _:b215627654 "2"^^ . _:b215627702 . _:b215626202 . . _:b215627703 . _:b215627696 . _:b215627486 . _:b215627402 . _:b215626582 . . _:b215627649 "2"^^ . _:b215627697 . . . _:b215627698 . _:b215626468 . _:b215627699 . _:b215627708 . _:b215627481 . . _:b215627648 "2"^^ . _:b215627709 . _:b215627710 . _:b215627711 . . _:b215627480 . _:b215627704 . _:b215627705 . _:b215627651 "2"^^ . _:b215627179 . _:b215627706 . _:b215627707 . _:b215626537 . _:b215627483 . _:b215627684 . _:b215627685 . _:b215627650 "2"^^ . _:b215627686 . . _:b215627687 . . . _:b215627482 . _:b215627680 . _:b215627681 . _:b215627661 "2"^^ . _:b215627682 . _:b215627683 . _:b215627692 . _:b215627493 . . _:b215627660 "2"^^ . _:b215627693 . _:b215627694 . _:b215626718 . . _:b215627695 . _:b215627272 . _:b215627688 . _:b215627492 . _:b215627689 . _:b215627663 "2"^^ . _:b215627690 . . _:b215627691 . . . _:b215627348 . _:b215627495 . _:b215627349 . _:b215627662 "2"^^ . _:b215627410 . . _:b215627350 . _:b215627351 . _:b215627344 . _:b215627494 . _:b215627345 . _:b215627657 "2"^^ . _:b215627346 . . _:b215627347 . _:b215627356 . _:b215627489 . _:b215627357 . _:b215627656 "2"^^ . _:b215627358 . _:b215626330 . _:b215627359 . _:b215627352 . _:b215627488 . . _:b215627659 "2"^^ . _:b215627353 . _:b215626110 . _:b215627354 . _:b215627355 . _:b215627332 . _:b215627491 . _:b215627333 . _:b215627658 "2"^^ . _:b215627334 . _:b215627335 . _:b215627328 . _:b215627538 . _:b215627490 . _:b215627329 . _:b215627669 "2"^^ . _:b215626815 . _:b215625836 . _:b215627330 . _:b215627331 . _:b215626390 . _:b215627340 . _:b215627501 . _:b215627341 . _:b215627668 "2"^^ . _:b215627342 . _:b215627343 . . _:b215627500 . _:b215627336 . _:b215627337 . _:b215627671 "2"^^ . _:b215627338 . _:b215627339 . _:b215626341 . _:b215627503 . _:b215627380 . _:b215626097 . _:b215627670 "2"^^ . _:b215627381 . _:b215627382 . _:b215627383 . _:b215627275 . _:b215627376 . _:b215627502 . _:b215627377 . _:b215627665 "2"^^ . _:b215627378 . _:b215627618 . _:b215627379 . _:b215627388 . _:b215627497 . . _:b215627389 . _:b215627664 "2"^^ . _:b215627390 . _:b215627391 . . _:b215627496 . _:b215627384 . . . . _:b215627667 "2"^^ . _:b215627385 . _:b215627386 . _:b215627387 . _:b215627364 . _:b215627499 . _:b215627365 . _:b215627666 "2"^^ . _:b215627366 . . _:b215627367 . . _:b215627360 . _:b215627498 . _:b215627361 . _:b215627677 "2"^^ . _:b215627362 . _:b215627363 . . _:b215627509 . _:b215627372 . . _:b215627676 "2"^^ . _:b215627373 . _:b215627374 . _:b215627375 . . _:b215627368 . _:b215627508 . . _:b215627369 . _:b215627679 "2"^^ . _:b215627370 . _:b215627371 . . _:b215627511 . _:b215627431 . _:b215627284 . . _:b215627285 . _:b215627678 "2"^^ . . . _:b215627286 . _:b215627287 . _:b215627280 . _:b215627510 . _:b215627281 . _:b215627673 "2"^^ . _:b215627282 . _:b215627283 . _:b215627292 . _:b215627505 . _:b215627293 . _:b215627672 "2"^^ . . _:b215627294 . _:b215627295 . _:b215627288 . _:b215627504 . . _:b215627675 "2"^^ . _:b215627289 . _:b215627290 . _:b215627291 . _:b215627268 . _:b215627507 . _:b215627369 . _:b215627348 . _:b215627269 . _:b215627674 "2"^^ . _:b215627270 . . _:b215626886 . _:b215627271 . _:b215627264 . _:b215627506 . _:b215627265 . _:b215627685 "2"^^ . _:b215627266 . _:b215627267 . _:b215627276 . _:b215627517 . _:b215627451 . _:b215627277 . _:b215627684 "2"^^ . _:b215627278 . _:b215627279 . _:b215627272 . _:b215627516 . . _:b215627687 "2"^^ . _:b215627273 . _:b215627274 . _:b215627275 . _:b215627316 . _:b215627519 . _:b215627317 . _:b215627686 "2"^^ . _:b215627318 . _:b215627319 . _:b215627312 . _:b215627518 . _:b215627313 . _:b215627681 "2"^^ . _:b215627142 . _:b215627314 . . _:b215627315 . . _:b215627513 . _:b215627324 . . _:b215627325 . _:b215627680 "2"^^ . _:b215627326 . . . _:b215627327 . . _:b215627512 . _:b215627320 . . _:b215627321 . _:b215627683 "2"^^ . _:b215627322 . _:b215627200 . . _:b215627323 . _:b215627300 . _:b215627515 . _:b215626331 . _:b215627682 "2"^^ . _:b215627301 . . _:b215627302 . _:b215627303 . _:b215627296 . _:b215627514 . _:b215627297 . _:b215627693 "2"^^ . _:b215627298 . _:b215627299 . . _:b215627013 . _:b215627308 . . _:b215627692 "2"^^ . _:b215627309 . _:b215627310 . _:b215626947 . . _:b215627311 . _:b215626416 . _:b215627304 . _:b215627012 . _:b215627305 . _:b215627695 "2"^^ . _:b215627306 . _:b215627307 . _:b215627476 . _:b215627015 . _:b215627477 . _:b215627694 "2"^^ . _:b215627478 . . _:b215627479 . . _:b215627472 . _:b215627014 . _:b215627473 . _:b215627689 "2"^^ . _:b215627474 . _:b215627475 . _:b215627484 . _:b215627009 . _:b215627485 . _:b215627688 "2"^^ . _:b215627015 . . _:b215627486 . . _:b215627487 . _:b215626154 . _:b215627480 . _:b215627008 . _:b215627481 . _:b215627691 "2"^^ . _:b215627482 . _:b215627483 . _:b215627460 . _:b215627011 . . _:b215627690 "2"^^ . _:b215627164 . _:b215627461 . . _:b215627462 . _:b215627463 . _:b215627456 . _:b215627010 . _:b215627457 . _:b215627701 "2"^^ . _:b215627458 . _:b215627459 . _:b215627468 . _:b215627021 . . _:b215627700 "2"^^ . _:b215627469 . _:b215627470 . _:b215627471 . _:b215627464 . _:b215627020 . _:b215627465 . _:b215627703 "2"^^ . _:b215627466 . _:b215627063 . _:b215627467 . _:b215627508 . _:b215627023 . _:b215627509 . _:b215627702 "2"^^ . _:b215627419 . _:b215627510 . _:b215627511 . _:b215627298 . _:b215627504 . _:b215627022 . _:b215627505 . _:b215627697 "2"^^ . _:b215627506 . _:b215627507 . _:b215627701 . _:b215627516 . _:b215627017 . _:b215625929 . _:b215627696 "2"^^ . _:b215627517 . _:b215627518 . _:b215627519 . _:b215627512 . _:b215627016 . _:b215626186 . _:b215627513 . _:b215627699 "2"^^ . _:b215627514 . _:b215627515 . _:b215627492 . _:b215627019 . _:b215626673 . _:b215627493 . _:b215627698 "2"^^ . _:b215627494 . _:b215627495 . . _:b215627018 . _:b215627488 . . _:b215627489 . _:b215627709 "2"^^ . _:b215627490 . . _:b215627007 . _:b215627491 . . _:b215627500 . _:b215627029 . . _:b215627708 "2"^^ . _:b215627501 . . _:b215627502 . . _:b215627503 . _:b215627496 . _:b215627028 . _:b215627497 . _:b215627711 "2"^^ . _:b215626294 . _:b215627498 . _:b215627499 . _:b215627412 . _:b215627031 . . _:b215627710 "2"^^ . _:b215627413 . . _:b215627414 . . _:b215627415 . _:b215627408 . _:b215627030 . _:b215627409 . _:b215627705 "2"^^ . _:b215627410 . . _:b215627411 . _:b215627420 . _:b215627025 . . _:b215627421 . _:b215627704 "2"^^ . _:b215627422 . _:b215627423 . _:b215627416 . _:b215627024 . _:b215626449 . _:b215627707 "2"^^ . _:b215627417 . _:b215627418 . _:b215627419 . _:b215627396 . _:b215627027 . _:b215627397 . _:b215627706 "2"^^ . _:b215627398 . _:b215626909 . _:b215627399 . _:b215627392 . _:b215627026 . _:b215627393 . _:b215627717 "2"^^ . _:b215627394 . _:b215627395 . . _:b215627037 . _:b215627404 . . _:b215627716 "2"^^ . _:b215627000 . _:b215627405 . . _:b215627406 . _:b215627407 . _:b215627400 . _:b215627036 . _:b215626861 . _:b215626027 . _:b215627719 "2"^^ . _:b215627401 . _:b215627402 . _:b215627462 . . _:b215627403 . _:b215627444 . _:b215627039 . _:b215627445 . _:b215627718 "2"^^ . _:b215627446 . _:b215626724 . _:b215627447 . . _:b215627038 . _:b215627440 . _:b215627441 . _:b215627713 "2"^^ . _:b215627468 . _:b215627442 . _:b215627133 . . _:b215627443 . _:b215627452 . _:b215627033 . _:b215627453 . _:b215627712 "2"^^ . _:b215625915 . _:b215627454 . _:b215627455 . . _:b215627032 . _:b215627448 . _:b215627449 . _:b215627715 "2"^^ . _:b215626227 . _:b215627450 . _:b215627451 . _:b215627428 . _:b215627035 . _:b215627429 . _:b215627714 "2"^^ . _:b215627430 . _:b215627431 . _:b215627024 . _:b215627424 . _:b116024 . _:b215627034 . _:b215627425 . _:b215627725 "2"^^ . _:b215627426 . _:b215627427 . . _:b215627045 . _:b215627436 . _:b215627437 . _:b215627724 "2"^^ . _:b215627438 . _:b215626698 . _:b215627439 . _:b215627432 . _:b215627044 . _:b215627433 . _:b215627727 "2"^^ . _:b215627434 . _:b215627435 . _:b215626108 . _:b215627047 . _:b215626068 . _:b215626069 . _:b215627726 "2"^^ . _:b215626070 . _:b215626104 . _:b215626071 . _:b215626064 . _:b215627046 . . _:b215627721 "2"^^ . _:b215626065 . _:b215626066 . _:b215627746 . _:b215626067 . _:b215626076 . _:b215627041 . _:b215626077 . _:b215627720 "2"^^ . _:b215626078 . _:b215627696 . . _:b215626079 . _:b215626072 . _:b215627040 . _:b215626073 . _:b215627723 "2"^^ . _:b215626074 . _:b215626075 . _:b215626052 . _:b215627043 . _:b215626053 . _:b215627722 "2"^^ . _:b215626054 . . . _:b215626055 . _:b215626048 . _:b215627042 . _:b215626049 . _:b215627733 "2"^^ . _:b215626050 . _:b215626051 . _:b215626060 . _:b215627053 . _:b215626061 . _:b215627732 "2"^^ . _:b215626062 . _:b215626063 . _:b215626056 . _:b215627052 . _:b215626057 . _:b215627735 "2"^^ . _:b215626058 . _:b215626059 . _:b215626100 . _:b215627055 . _:b215626101 . _:b215627734 "2"^^ . . _:b215626102 . . _:b215626103 . _:b215626096 . _:b215627054 . _:b215626097 . _:b215627744 . _:b215627729 "2"^^ . _:b215626098 . _:b215626099 . . _:b215627049 . _:b215626108 . . _:b215627728 "2"^^ . _:b215626109 . _:b215626110 . _:b215626111 . . _:b215627048 . _:b215626104 . _:b215626105 . _:b215627731 "2"^^ . . _:b215626106 . _:b215626107 . _:b215626084 . _:b215627162 . _:b215627051 . _:b215626085 . _:b215627730 "2"^^ . _:b215626086 . _:b215626087 . _:b215626080 . _:b215627050 . _:b215626081 . _:b215627741 "2"^^ . _:b215626082 . _:b215626083 . _:b215626092 . _:b215627061 . _:b215626093 . _:b215627740 "2"^^ . _:b215626094 . . _:b215626095 . _:b215626093 . _:b215626088 . _:b215627060 . _:b215626089 . _:b215627743 "2"^^ . . _:b215626090 . _:b215626091 . _:b215626004 . _:b215627063 . _:b215626005 . _:b215627742 "2"^^ . . _:b215626006 . . _:b215626007 . _:b215626000 . _:b215627062 . _:b215626001 . _:b215627737 "2"^^ . _:b215626002 . _:b215627433 . _:b215626003 . _:b215626012 . _:b215627057 . _:b215626013 . _:b215627736 "2"^^ . _:b215626014 . _:b215626015 . . _:b215627056 . _:b215626008 . . _:b215626009 . _:b215627739 "2"^^ . _:b215626010 . . _:b215626011 . _:b215625988 . _:b215627059 . . _:b215627738 "2"^^ . _:b215625989 . _:b215625990 . _:b215625991 . _:b215625984 . _:b215627058 . _:b215626155 . _:b215627749 "2"^^ . _:b215625985 . _:b215625986 . _:b215625987 . _:b215626999 . _:b215625996 . _:b215627069 . _:b215625997 . _:b215627748 "2"^^ . _:b215625998 . _:b215627496 . _:b215625999 . _:b215625992 . _:b215627068 . _:b215625993 . . _:b215625994 . . _:b215625995 . _:b215626036 . _:b215627071 . _:b215626037 . . _:b215627232 . _:b215626038 . _:b215626039 . _:b215626032 . _:b215627070 . _:b215626033 . _:b215627745 "2"^^ . _:b215626034 . _:b215626035 . _:b215626044 . _:b215627065 . _:b215626045 . _:b215627744 "2"^^ . _:b215626046 . _:b215626047 . _:b215626040 . _:b215627064 . _:b215626041 . _:b215627747 "2"^^ . _:b215626042 . _:b215626043 . _:b215626241 . _:b215627067 . _:b215626020 . . _:b215627746 "2"^^ . _:b215626021 . _:b215626022 . _:b215626023 . . _:b215626016 . _:b215627066 . _:b215626017 . _:b215626018 . _:b215626019 . . _:b215627077 . _:b215626028 . . _:b215626029 . _:b215626030 . _:b215626031 . . _:b215627076 . _:b215626024 . _:b215626025 . . . _:b215626026 . _:b215626027 . _:b215626196 . _:b215627079 . _:b215626197 . _:b215626198 . _:b215626621 . _:b215626199 . _:b215626192 . _:b215627078 . . . _:b215626703 . _:b215626419 . _:b215626193 . _:b215626194 . _:b215626195 . . _:b215626204 . _:b215627073 . _:b215626942 . _:b215626205 . _:b215627666 . _:b215626922 . _:b215626206 . . _:b215626207 . _:b215626200 . _:b215627072 . _:b215626201 . _:b215625840 . _:b215626202 . _:b215626203 . _:b215626180 . _:b215627075 . _:b215626181 . _:b215626182 . _:b215626183 . . _:b215627074 . _:b215626176 . _:b215626177 . _:b215626178 . _:b215626179 . _:b215626188 . _:b215627085 . _:b215626189 . _:b215626190 . . _:b215626191 . _:b215626184 . _:b215627084 . _:b215626185 . _:b215626186 . _:b215626187 . _:b215626228 . _:b215627087 . _:b215626229 . _:b215626230 . _:b215626231 . . _:b215626224 . _:b215627086 . _:b215626225 . _:b215626226 . _:b215626227 . _:b215626236 . _:b215627585 . _:b215627081 . . _:b215626237 . . _:b215626238 . _:b215626498 . _:b215626239 . _:b215626232 . _:b215627080 . . _:b215626233 . _:b215626234 . _:b215626235 . _:b215626212 . _:b215627083 . _:b215626213 . . _:b215626730 . _:b215626214 . _:b215626215 . _:b215626208 . _:b215627082 . _:b215626209 . _:b215626210 . _:b215627349 . . _:b215626211 . _:b215626220 . _:b215627093 . . _:b215626221 . _:b215626222 . _:b215626223 . _:b215626216 . _:b215627092 . _:b215626217 . _:b215626218 . _:b215626219 . _:b215627219 . _:b215625976 . _:b215626132 . _:b215627095 . _:b215626133 . . _:b215626134 . _:b215626135 . . _:b215627094 . _:b215626128 . . _:b215627727 . _:b215626129 . . _:b215626130 . _:b215626131 . _:b215626140 . _:b215627089 . _:b215626141 . _:b215626142 . _:b215626152 . _:b215626143 . _:b215626136 . _:b215627088 . _:b215626137 . _:b215626138 . _:b215626139 . _:b215626116 . _:b215627091 . _:b215626117 . _:b215627016 . _:b215626148 . _:b215626735 . _:b215626118 . _:b215626119 . _:b215626112 . _:b215627090 . _:b215626113 . _:b215626114 . _:b215626757 "3"^^ . _:b215626115 . _:b215626124 . _:b215627101 . _:b215626125 . _:b215626126 . _:b215626756 "3"^^ . _:b215626127 . _:b215626120 . _:b215627100 . _:b215626121 . _:b215626122 . _:b215626759 "3"^^ . _:b215626123 . . _:b215627320 . _:b215627103 . _:b215626164 . _:b215626165 . . _:b215626758 "3"^^ . _:b215626166 . _:b215626167 . _:b215626160 . _:b215627102 . _:b215626161 . _:b215626162 . _:b215626753 "3"^^ . _:b215626163 . _:b215626172 . _:b215627097 . _:b215626173 . _:b215626174 . _:b215626752 "3"^^ . _:b215626607 . _:b215626175 . _:b215626168 . _:b215627096 . _:b215626169 . _:b215626170 . _:b215626755 "3"^^ . _:b215626171 . _:b215626148 . _:b215627099 . . _:b215626149 . _:b215626150 . _:b215626754 "3"^^ . _:b215626151 . . _:b215627098 . _:b215626144 . _:b215626145 . _:b215626146 . _:b215626765 "3"^^ . _:b215626147 . _:b215626156 . _:b215627109 . . _:b215626728 . _:b215626157 . _:b215626158 . _:b215626764 "3"^^ . _:b215626159 . _:b215626152 . _:b215627108 . _:b215626153 . _:b215626154 . _:b215626767 "3"^^ . . _:b215626155 . _:b215627111 . _:b215626021 . _:b215626766 "3"^^ . _:b215627110 . _:b215626761 "3"^^ . _:b215627105 . . . _:b215626981 . _:b215626760 "3"^^ . _:b215626674 . _:b215627104 . . _:b215626763 "3"^^ . _:b215627570 . _:b215627107 . _:b215626762 "3"^^ . _:b215627103 . . _:b215627106 . _:b215626669 . _:b215626773 "2"^^ . . _:b215626985 . _:b215626762 . _:b215627117 . _:b215626772 "2"^^ . _:b215626513 . _:b215627116 . _:b215626775 "2"^^ . _:b215626235 . _:b215625844 . _:b215627119 . _:b215625845 . _:b215626774 "2"^^ . _:b215625846 . _:b215625847 . _:b215625840 . _:b215627118 . _:b215625841 . . _:b215626769 "3"^^ . _:b215625842 . _:b215625843 . _:b215626251 . . _:b215627113 . _:b215625852 . _:b215626163 . _:b215627282 . _:b215625853 . _:b215625854 . _:b215626768 "3"^^ . _:b215625855 . . _:b215627112 . _:b215625848 . _:b215626236 . . _:b215627028 . _:b215626771 "2"^^ . _:b215625849 . _:b215625850 . . _:b215625851 . _:b215627115 . _:b215626770 "2"^^ . . . _:b215627030 . _:b215627114 . _:b215626781 "2"^^ . _:b215626535 . _:b215625836 . _:b215627125 . _:b215625837 . _:b215626780 "2"^^ . _:b215625838 . _:b215625839 . _:b215627124 . _:b215626783 "2"^^ . _:b215625834 . _:b215625835 . _:b215627127 . _:b215626782 "2"^^ . _:b215627506 . _:b215627405 . _:b215627126 . _:b215626777 "2"^^ . _:b215626029 . _:b215627121 . _:b215626776 "2"^^ . . _:b215627120 . _:b215626779 "2"^^ . _:b215627614 . _:b215627069 . _:b215627123 . _:b215626778 "2"^^ . _:b215627122 . _:b215626789 "2"^^ . _:b215627133 . _:b215626788 "2"^^ . _:b215626544 . _:b215627132 . _:b215626791 "2"^^ . _:b215626996 . _:b215627135 . _:b215626790 "2"^^ . _:b215627134 . _:b215627592 . _:b215626785 "2"^^ . _:b215626479 . _:b215626711 . _:b215627129 . _:b215626784 "2"^^ . _:b215627128 . . _:b215626787 "2"^^ . _:b215627131 . _:b215626575 . _:b215626786 "2"^^ . _:b215626780 . _:b215626399 . _:b215627568 . _:b215627130 . . _:b215626797 "2"^^ . _:b215626431 . _:b215627141 . . _:b215626796 "2"^^ . . _:b215625937 . _:b215627140 . _:b215627170 . _:b215626799 "2"^^ . _:b215625940 . _:b215627143 . _:b215625941 . _:b215626798 "2"^^ . _:b215625913 . _:b215625942 . _:b215625943 . _:b215625936 . _:b215627142 . _:b215625937 . _:b215627460 . _:b215626793 "2"^^ . _:b215626376 . _:b215625938 . _:b215625939 . _:b215625918 . _:b215627137 . _:b215625948 . _:b215625949 . _:b215626792 "2"^^ . _:b215625950 . _:b215625951 . _:b215625944 . _:b215627136 . _:b215625945 . _:b215626795 "2"^^ . _:b215626613 . _:b215625946 . _:b215625947 . _:b215627458 . _:b215625924 . _:b215627139 . _:b215625925 . _:b215626794 "2"^^ . _:b215625926 . _:b215625927 . _:b215625920 . _:b215627138 . _:b215625921 . _:b215626805 "2"^^ . _:b215625922 . _:b215626732 . _:b215625923 . _:b215625932 . _:b215627149 . _:b215625933 . _:b215627484 . _:b215626804 "2"^^ . _:b215625934 . _:b215625935 . _:b215625928 . _:b215627148 . . _:b215626807 "2"^^ . _:b215625929 . _:b215625930 . . _:b215625931 . _:b215625972 . _:b215627151 . _:b215625973 . _:b215626806 "2"^^ . _:b215625974 . _:b215625975 . _:b215625968 . _:b215627150 . _:b215625969 . _:b215626801 "2"^^ . _:b215626639 . _:b215625970 . _:b215625971 . _:b215625980 . _:b215627145 . _:b215625981 . _:b215626800 "2"^^ . _:b215625982 . _:b215625983 . _:b215627104 . _:b215625976 . _:b215627144 . _:b215625977 . _:b215626803 "2"^^ . _:b215625978 . _:b215625979 . _:b215627310 . _:b215625956 . _:b215627147 . _:b215625957 . _:b215626802 "2"^^ . _:b215625958 . _:b215625959 . _:b215625952 . _:b215627146 . . _:b215626813 "2"^^ . _:b215625953 . . _:b215625954 . _:b215625955 . _:b215625964 . _:b215627157 . _:b215627049 . _:b215626808 . _:b215625965 . _:b215626812 "2"^^ . _:b215625966 . _:b215625967 . . _:b215627156 . _:b215626591 . _:b215625960 . _:b215625961 . _:b215626815 "2"^^ . . _:b215626715 . _:b215625962 . _:b215625963 . _:b215626259 . _:b215627717 . _:b215627159 . _:b215625876 . . _:b215625877 . _:b215626814 "2"^^ . _:b215626188 . _:b215625878 . . _:b215625879 . . _:b215627158 . _:b215626976 . _:b215626767 . _:b215625872 . _:b215625873 . _:b215626809 "2"^^ . _:b215625874 . _:b215625875 . _:b215625884 . _:b215627153 . _:b215625885 . _:b215626808 "2"^^ . _:b215625886 . _:b215625887 . _:b215625880 . _:b215627152 . _:b215625881 . _:b215626811 "2"^^ . _:b215625882 . _:b215627562 . . _:b215625883 . . _:b215625860 . _:b215627155 . _:b215626335 . _:b215626810 "2"^^ . _:b215625861 . _:b215625862 . _:b215625863 . . _:b215627154 . _:b215625856 . _:b215625857 . _:b215626821 "2"^^ . . _:b215625858 . . _:b215625859 . _:b215626221 . _:b215627165 . _:b215625868 . . _:b215626820 "2"^^ . . _:b215625869 . . _:b215625870 . _:b215625871 . _:b215625864 . _:b215627164 . _:b215627139 . _:b215625865 . _:b215626823 "2"^^ . _:b215625866 . _:b215625867 . . _:b215627167 . _:b215626771 . _:b215625908 . _:b215625909 . _:b215626822 "2"^^ . _:b215625910 . _:b215625911 . . _:b215627166 . _:b215625904 . _:b215625905 . _:b215626817 "2"^^ . _:b215625906 . _:b215625907 . _:b215625916 . _:b215627161 . _:b215625917 . _:b215626816 "2"^^ . _:b215625918 . _:b215625919 . _:b215625912 . _:b215627160 . . _:b215626819 "2"^^ . _:b215625913 . _:b215625914 . _:b215625915 . _:b215625892 . _:b215627163 . . _:b215626836 . _:b215626818 "2"^^ . _:b215625893 . _:b215625894 . _:b215625895 . _:b215625888 . _:b215627162 . _:b215625889 . _:b215626829 "2"^^ . _:b215625890 . _:b215625891 . _:b215625900 . _:b215627173 . _:b215625901 . _:b215626828 "2"^^ . _:b215625902 . _:b215625903 . _:b215625896 . _:b215627172 . _:b215625897 . _:b215626831 "2"^^ . _:b215625898 . _:b215627483 . _:b215625899 . _:b215626580 . _:b215627175 . _:b215626581 . _:b215626830 "2"^^ . _:b215626582 . _:b215626583 . _:b215626576 . _:b215627174 . . _:b215626825 "2"^^ . _:b215626577 . _:b215626578 . _:b215626579 . . _:b215627169 . _:b215626588 . . _:b215626589 . _:b215626824 "2"^^ . _:b215626590 . . _:b215626591 . _:b215626584 . _:b215627168 . . _:b215626827 "2"^^ . _:b215626585 . . _:b215626586 . _:b215626587 . _:b215626564 . _:b215627171 . . _:b215626565 . _:b215626826 "2"^^ . _:b215626566 . . _:b215627678 . _:b215626567 . _:b215626560 . _:b215627170 . _:b215626561 . _:b215626837 "2"^^ . . _:b215626562 . _:b215626563 . _:b215626572 . _:b215627181 . _:b215626573 . _:b215626836 "2"^^ . _:b215626574 . _:b215626568 . _:b215626575 . _:b215625942 . _:b215627180 . _:b215626568 . _:b215626569 . _:b215626839 "2"^^ . _:b215626570 . _:b215626750 . _:b215626571 . _:b215626612 . _:b215627183 . _:b215626613 . _:b215626838 "2"^^ . _:b215626614 . _:b215626433 . _:b215626615 . _:b215626608 . _:b215627182 . _:b215626609 . _:b215626833 "2"^^ . _:b215626610 . _:b215626005 . _:b215626611 . . _:b215627177 . _:b215626620 . _:b215626621 . _:b215626832 "2"^^ . _:b215626622 . _:b215626623 . _:b215626616 . _:b215627176 . _:b215626617 . _:b215626835 "2"^^ . . _:b215626618 . _:b215626619 . _:b215626647 . . _:b215627179 . _:b215626596 . _:b215626597 . _:b215626834 "2"^^ . _:b215626598 . _:b215627231 . _:b215626599 . _:b215626592 . _:b215627178 . _:b215626593 . _:b215626845 "2"^^ . _:b215626594 . _:b215626595 . _:b215626604 . _:b215627189 . _:b215626605 . _:b215626844 "2"^^ . . _:b116046 "Several studies (33, 34) have presented evidence that the CD4+CD25+ population in the 3dTx model recognizes the same set of autoantigens as the autoantigen-specific effector pool, but these findings have not been confirmed (>>35<<). No data are available as to the antigen-specificity of the regulatory cells in the models where lymphopenic animals are reconstituted with CD45RBlow cells although it has been proposed that the T cells that mediate dominant tolerance" . _:b215626606 . . _:b215626607 . _:b215626600 . _:b215627188 . _:b215626601 . _:b215626847 "2"^^ . _:b215626602 . _:b215626603 . . _:b215627191 . _:b215626516 . _:b215626517 . _:b215626846 "2"^^ . _:b215626518 . _:b215626519 . _:b215626512 . _:b215627190 . _:b215626513 . _:b215626841 "2"^^ . _:b215626514 . _:b215626515 . _:b215626524 . _:b215627185 . _:b215627019 . _:b215626525 . _:b215626840 "2"^^ . _:b215626526 . _:b215626527 . _:b215626520 . _:b215627184 . . _:b215626843 "2"^^ . _:b215626521 . _:b215626522 . _:b215626523 . _:b215626500 . _:b215627187 . _:b215626501 . _:b215626842 "2"^^ . _:b215626502 . . _:b215626503 . _:b215626496 . _:b215627186 . _:b215626497 . _:b215626853 "2"^^ . _:b215626498 . _:b215626499 . _:b215626508 . _:b215627197 . _:b215626509 . _:b215626852 "2"^^ . _:b215626510 . _:b215626511 . _:b215626504 . _:b215627196 . . _:b215626855 "2"^^ . _:b215626505 . . _:b215626506 . _:b215626507 . _:b215626548 . _:b215627199 . _:b215626365 . _:b215626854 "2"^^ . _:b215626549 . _:b215626550 . _:b215626940 . . _:b215626551 . . _:b215626544 . _:b215627198 . _:b215626545 . _:b215626849 "2"^^ . _:b215626546 . _:b215626547 . _:b215626556 . _:b215627193 . _:b215626557 . _:b215626848 "2"^^ . _:b215625980 . _:b215626558 . _:b215626559 . _:b215626552 . _:b215627192 . _:b215626794 . . _:b215626553 . _:b215626851 "2"^^ . _:b215626554 . . _:b215626555 . _:b215626532 . _:b215627195 . . _:b215626850 "2"^^ . _:b215626533 . _:b215626534 . _:b215626535 . _:b215626528 . _:b215627194 . _:b215626529 . _:b215626861 "2"^^ . _:b215626530 . _:b215626531 . _:b215626540 . _:b215627205 . _:b215626541 . _:b215626860 "2"^^ . _:b215625928 . _:b215626542 . _:b215626543 . _:b215626536 . _:b215627204 . _:b215626537 . _:b215626863 "2"^^ . . _:b215626538 . _:b215626084 . . _:b215626978 . _:b215626539 . _:b215626458 . _:b215627207 . _:b215626708 . . _:b215626862 "2"^^ . _:b215626709 . _:b215626710 . . . _:b215626711 . . _:b215627206 . _:b215626704 . _:b215626106 . _:b215626705 . _:b215626857 "2"^^ . _:b215626706 . _:b215626707 . _:b215626716 . _:b215627201 . _:b215626717 . _:b215626856 "2"^^ . . _:b215626718 . . _:b215626719 . . _:b215626286 . _:b215626712 . _:b215627200 . _:b215626713 . _:b215626859 "2"^^ . _:b215626714 . _:b215626715 . _:b215626692 . _:b215627203 . . _:b215626693 . _:b215626858 "2"^^ . _:b215626694 . _:b215626695 . _:b215626688 . _:b215627202 . _:b215627167 . _:b215626689 . _:b215626869 "2"^^ . . _:b215626690 . _:b215626691 . _:b215626700 . _:b215627213 . . _:b215626868 "2"^^ . _:b215626701 . _:b215626702 . _:b215626703 . _:b215626696 . _:b215627212 . _:b215626697 . _:b215627636 . _:b215626871 "2"^^ . _:b215626698 . _:b215626699 . . _:b215627215 . _:b215626740 . _:b215626741 . _:b215626870 "2"^^ . _:b215626742 . _:b215626743 . _:b215626736 . _:b215627214 . _:b215626737 . _:b215626865 "2"^^ . _:b215626738 . _:b215626739 . _:b215626375 . _:b215627209 . _:b215626748 . _:b215626749 . _:b215626864 "2"^^ . _:b215626750 . _:b215626893 . . _:b215626751 . _:b215626744 . _:b215627208 . . _:b215626867 "2"^^ . _:b215626745 . . _:b215626746 . _:b215626747 . _:b215626724 . _:b215627211 . _:b215626725 . _:b215626866 "2"^^ . . _:b215627042 . _:b215626726 . _:b215626727 . _:b215626720 . _:b215627210 . _:b215626721 . _:b215626877 "2"^^ . . _:b215627432 . _:b215626722 . . _:b215626723 . _:b215626732 . _:b215627221 . . _:b215626876 "2"^^ . _:b215626733 . . _:b215626734 . _:b215626735 . _:b215626728 . _:b215627220 . _:b215626729 . _:b215626879 "2"^^ . . _:b215626956 . _:b215626730 . _:b215626731 . _:b215626644 . _:b215627223 . _:b215626645 . _:b215626878 "2"^^ . . _:b215626646 . _:b215626647 . _:b215626759 . . _:b215627222 . _:b215626640 . . _:b215626873 "2"^^ . _:b215626641 . _:b215626642 . _:b215626643 . _:b215626652 . _:b215627217 . _:b215626653 . _:b215626872 "2"^^ . _:b215626654 . _:b215627184 . _:b215626655 . _:b215626756 . . _:b215627216 . _:b215626648 . _:b215626649 . _:b215626875 "2"^^ . _:b215626098 . _:b215626650 . _:b215626651 . _:b215626628 . _:b215627219 . _:b215626629 . _:b215626874 "2"^^ . _:b215626630 . _:b215627396 . _:b215626631 . _:b215626624 . _:b215627218 . _:b215626625 . _:b215626885 "2"^^ . _:b215626689 . _:b215626626 . _:b215627697 . _:b215626627 . _:b215626636 . _:b215627229 . _:b215626637 . _:b215626884 "2"^^ . _:b215626606 . _:b215626638 . . _:b215626385 . _:b215626639 . _:b215626632 . _:b215627228 . _:b215626633 . _:b215626887 "2"^^ . . _:b215626634 . _:b215626635 . _:b215626676 . _:b215627231 . . _:b215626886 "2"^^ . _:b215626677 . _:b215626678 . _:b215626679 . _:b215626672 . _:b215627230 . _:b215626673 . _:b215626881 "2"^^ . . _:b215626674 . _:b215626675 . _:b215626684 . _:b215627225 . _:b215626685 . _:b215626880 "2"^^ . _:b215626686 . _:b215626687 . _:b215627250 . _:b215626573 . _:b215625887 . _:b215627224 . _:b215626680 . _:b215626681 . _:b215626883 "2"^^ . _:b215626682 . _:b215626979 . _:b215626683 . _:b215626660 . _:b215627227 . _:b215626661 . _:b215626882 "2"^^ . _:b215626662 . _:b215626663 . _:b215626656 . _:b215627226 . _:b215626117 . _:b215626893 "2"^^ . _:b215626657 . _:b215626658 . _:b215626659 . _:b215626668 . _:b215627237 . _:b215626669 . _:b215626892 "2"^^ . _:b215626670 . _:b215626671 . _:b215626664 . _:b215627236 . . _:b215626895 "2"^^ . _:b215626665 . _:b215626666 . _:b215627441 . _:b215626667 . _:b215626324 . _:b215627239 . _:b215626965 . _:b215626325 . _:b215626894 "2"^^ . _:b215626326 . . _:b215626327 . _:b215626320 . _:b215627238 . _:b215626321 . _:b215626889 "2"^^ . _:b215626322 . _:b215626323 . _:b215626332 . _:b215627233 . _:b215626333 . _:b215626888 "2"^^ . _:b215626334 . _:b215626335 . _:b215626328 . _:b215627232 . . _:b215626891 "2"^^ . _:b215626329 . _:b215626330 . _:b215626331 . . _:b215627235 . _:b215626308 . . _:b215626890 "2"^^ . _:b215626309 . _:b215626310 . _:b215626311 . _:b215626304 . _:b215627234 . _:b215626305 . _:b215626901 "2"^^ . . _:b215626306 . _:b215626307 . _:b215626316 . _:b215627245 . _:b215626317 . _:b215626900 "2"^^ . _:b215626318 . . _:b215626319 . _:b215625939 . _:b215627584 . _:b215627244 . _:b215626312 . _:b215626505 . . _:b215626903 "2"^^ . _:b215626313 . _:b215626314 . _:b215626555 . _:b215626315 . _:b215626356 . _:b215627247 . _:b215626357 . _:b215626902 "2"^^ . _:b215626358 . _:b215626359 . _:b215626352 . _:b215627246 . _:b215626260 . _:b215626897 . _:b215626897 "2"^^ . _:b215626353 . _:b215626354 . _:b215627210 . _:b215626355 . _:b215626364 . _:b215627241 . _:b116022 "materials and methods" . _:b215626896 "2"^^ . _:b215626365 . _:b215626366 . _:b215626367 . . _:b215627240 . _:b215626360 . _:b215626361 . _:b215626899 "2"^^ . _:b215626864 . . _:b215626362 . _:b215626363 . . _:b215627243 . _:b215626340 . _:b215626341 . _:b215626898 "2"^^ . _:b215626342 . _:b215627243 . _:b215626180 . _:b215626343 . . _:b215626336 . _:b215627242 . . _:b215627302 . _:b215626909 "2"^^ . _:b215626337 . _:b215626338 . _:b215626339 . _:b215626348 . _:b215627253 . . _:b215626908 "2"^^ . _:b215626349 . _:b215626350 . . _:b215626351 . _:b215626344 . _:b215627252 . _:b215626345 . _:b215626911 "2"^^ . _:b215626346 . _:b215626347 . . _:b215627452 . _:b215627255 . _:b215626260 . _:b215626261 . _:b215626910 "2"^^ . _:b215626262 . _:b215626263 . . _:b215627254 . _:b215626256 . _:b215626257 . _:b215626905 "2"^^ . _:b215626258 . _:b116049 "No studies have suggested that receptor-based immunoregulation (37, >>38<<) is operative in these model systems." . _:b215626259 . _:b215626268 . _:b215627249 . _:b215626269 . _:b215627589 . _:b215626904 "2"^^ . _:b215626289 . _:b215626270 . _:b215626271 . _:b215626264 . _:b215627248 . _:b215626265 . _:b215626907 "2"^^ . . _:b215626266 . . _:b215626267 . . _:b215627515 . _:b215627251 . _:b215626244 . _:b215626245 . _:b215627653 . _:b215626966 . _:b215626906 "2"^^ . _:b215626246 . _:b215626247 . _:b215626240 . _:b215627250 . _:b215626241 . _:b215626917 "2"^^ . _:b215626543 . _:b215626242 . _:b215626243 . _:b215626252 . _:b215627261 . _:b215626253 . _:b215626916 "2"^^ . _:b215626254 . _:b215626255 . _:b215626248 . _:b215627260 . . _:b215626919 "2"^^ . _:b215626249 . _:b215626250 . _:b215626251 . . _:b215627263 . _:b215626292 . _:b215626293 . _:b215626918 "2"^^ . _:b215626294 . _:b215626295 . _:b215626288 . _:b215627262 . . _:b215627256 . _:b215626913 "2"^^ . _:b215626289 . _:b215626290 . . _:b215626291 . _:b215626300 . _:b215627583 . _:b215627257 . _:b215626301 . _:b215626912 "2"^^ . _:b215626302 . . _:b215626303 . _:b215626296 . _:b215627256 . _:b215626297 . _:b215626915 "2"^^ . _:b215626298 . _:b215626299 . _:b215626276 . _:b215627259 . _:b215626277 . _:b215626914 "2"^^ . _:b215626278 . _:b215626279 . _:b215626272 . _:b215627258 . _:b215626273 . _:b215626925 "2"^^ . _:b215626274 . _:b215626275 . _:b215626284 . _:b215626757 . _:b215626285 . _:b215626932 . _:b215626924 "2"^^ . _:b215626286 . _:b215626287 . _:b215626280 . _:b215626756 . _:b215626281 . _:b215626927 "2"^^ . _:b215626282 . _:b215626028 . _:b215626283 . _:b215626452 . _:b215626759 . . _:b215626926 "2"^^ . _:b215626453 . _:b215626454 . . _:b215626455 . _:b215626448 . _:b215626758 . _:b215626449 . _:b215626921 "2"^^ . _:b215626450 . . _:b215626451 . _:b215626460 . _:b215627148 . _:b215626753 . _:b215626461 . _:b215626920 "2"^^ . _:b215626462 . _:b215626463 . _:b215626456 . _:b215626752 . _:b215626457 . _:b215626923 "2"^^ . _:b215626458 . . _:b215626459 . _:b215626436 . _:b215626755 . _:b215626277 . _:b215626922 "2"^^ . _:b215626437 . _:b215626438 . _:b215626819 . _:b215626439 . _:b215626359 . _:b215626754 . _:b215626432 . . _:b215626933 "2"^^ . _:b215626433 . _:b215626434 . . _:b215626435 . . _:b215625983 . _:b215626444 . _:b215626765 . . _:b215626932 "2"^^ . _:b215626445 . _:b215626446 . _:b215626447 . _:b215627113 . _:b215626440 . _:b215626764 . _:b215626441 . _:b215626935 "2"^^ . _:b215626442 . _:b215626443 . . _:b215626767 . _:b215626484 . _:b215626485 . _:b215626934 "2"^^ . . _:b215626486 . . _:b215626938 . _:b215626487 . _:b215626480 . _:b215626766 . _:b215626481 . _:b215626929 "2"^^ . _:b215626482 . . _:b215626483 . . _:b215626492 . _:b215626761 . _:b215626493 . _:b215626928 "2"^^ . _:b215626494 . _:b215626205 . _:b215626495 . . _:b215626760 . _:b215626488 . _:b215626489 . _:b215626931 "2"^^ . _:b215626490 . _:b215626491 . _:b215626468 . _:b215626763 . _:b215626469 . _:b215627609 . _:b215626930 "2"^^ . _:b215626739 . . _:b215626470 . _:b215626471 . _:b215626464 . _:b215626762 . . _:b215626941 "2"^^ . _:b215626465 . _:b215626466 . . _:b215626467 . . _:b215626773 . _:b215626476 . _:b215626477 . _:b215626940 "2"^^ . _:b215626478 . . _:b215626479 . _:b215626472 . _:b215626772 . _:b215626473 . _:b215626943 "2"^^ . _:b215626474 . _:b215626048 . _:b215626475 . _:b215626388 . _:b215626775 . _:b215626389 . _:b215626942 "2"^^ . _:b215626390 . _:b215626391 . _:b215626384 . _:b215626774 . _:b215626385 . _:b215626937 "2"^^ . _:b215626386 . _:b215626387 . _:b215627034 . _:b215626396 . _:b215626769 . _:b215626397 . _:b215626936 "2"^^ . _:b215626398 . _:b215626399 . _:b215626392 . _:b215626768 . _:b215626393 . _:b215626939 "2"^^ . _:b215626394 . _:b215626949 . _:b215626395 . . _:b215626771 . _:b215626372 . _:b215626373 . _:b215626938 "2"^^ . _:b215626374 . _:b215626252 . _:b215626375 . _:b215626368 . _:b215626770 . _:b215626369 . _:b215626949 "2"^^ . _:b215626370 . _:b215626371 . _:b215626380 . _:b215626781 . _:b215626381 . _:b215626948 "2"^^ . _:b215626382 . _:b215626383 . _:b215626376 . _:b215626780 . . _:b215626951 "2"^^ . _:b215626377 . _:b215626378 . _:b215626379 . _:b215626420 . _:b215626783 . _:b215626421 . _:b215626950 "2"^^ . _:b215626422 . _:b215626598 . _:b215626423 . . _:b215626782 . _:b215626416 . _:b215626417 . _:b215626945 "2"^^ . _:b215626418 . _:b215626419 . _:b215626428 . _:b215627281 . _:b215626777 . _:b215625884 . _:b215626944 "2"^^ . _:b215626429 . _:b215626430 . _:b215626431 . _:b215626424 . _:b215626776 . _:b215626425 . _:b215626947 "2"^^ . _:b215626459 . _:b215626426 . _:b215626298 . _:b215626427 . . _:b215626779 . _:b215626404 . _:b215626405 . _:b215626946 "2"^^ . _:b215626406 . _:b215626407 . _:b215625943 . _:b215626778 . _:b215626400 . _:b215626401 . _:b215626957 "2"^^ . _:b215626402 . . _:b215626403 . _:b215626412 . _:b215626789 . _:b215626413 . _:b215626956 "2"^^ . _:b215626414 . _:b215626415 . . _:b215627478 . _:b215626788 . _:b215626408 . . _:b215626959 "2"^^ . _:b215626409 . _:b215626410 . _:b215626411 . _:b215626791 . _:b215626958 "2"^^ . . _:b215626790 . _:b215626953 "2"^^ . _:b215626632 . _:b215626785 . _:b215626952 "2"^^ . . _:b215626043 . _:b215626784 . _:b215627527 . _:b215626955 "2"^^ . _:b215626137 . _:b215626787 . _:b215626954 "2"^^ . . _:b215626786 . _:b215626965 "2"^^ . _:b215626797 . _:b215626964 "2"^^ . _:b215626796 . _:b215626967 "2"^^ . _:b215626799 . _:b215627406 . _:b215626966 "2"^^ . _:b215626798 . _:b215626961 "2"^^ . _:b215627602 . . _:b215626793 . _:b215625941 . _:b215627381 . _:b215626960 "2"^^ . . _:b215626792 . _:b215626963 "2"^^ . . . _:b215626795 . _:b215626744 . _:b215626962 "2"^^ . . _:b215626794 . . _:b215626973 "2"^^ . _:b215626805 . . _:b215626972 "2"^^ . _:b215626804 . _:b215626975 "2"^^ . _:b215627721 . _:b215627532 . _:b215627647 . . _:b215626807 . _:b215626974 "2"^^ . _:b215626806 . _:b215626969 "2"^^ . _:b215626801 . _:b215626968 "2"^^ . . _:b215626800 . _:b215626421 . _:b215626971 "2"^^ . _:b215627547 . _:b215626803 . . _:b215626970 "2"^^ . _:b215626223 . _:b215627268 . _:b215626823 . _:b215626802 . _:b215626981 "2"^^ . _:b215627147 . _:b215626813 . _:b215626980 "2"^^ . _:b215626812 . _:b215627356 . _:b215626983 "2"^^ . _:b215627127 . _:b215626467 . . _:b215626815 . _:b215626982 "2"^^ . . _:b215626814 . . . _:b215626977 "2"^^ . _:b215626809 . _:b215627479 . _:b215626976 "2"^^ . . _:b215626808 . _:b215626979 "2"^^ . _:b215627074 . _:b215626811 . _:b215626978 "2"^^ . _:b215626810 . _:b215626989 "2"^^ . _:b215626821 . _:b215626988 "2"^^ . _:b215626990 . _:b215626820 . _:b215626994 . _:b215626991 "2"^^ . . _:b215626823 . . _:b215626990 "2"^^ . _:b215626822 . _:b215626985 "2"^^ . _:b215627361 . _:b215626817 . _:b215626984 "2"^^ . _:b215626816 . _:b215626987 "2"^^ . _:b215626267 . _:b215626819 . . _:b215626986 "2"^^ . . _:b215627747 . _:b215626818 . . _:b215626997 "2"^^ . _:b215626829 . _:b215626996 "2"^^ . _:b215626016 . _:b215627687 . _:b215626828 . _:b215626999 "2"^^ . . _:b215627008 . _:b215626831 . . _:b215626998 "2"^^ . _:b215626413 . _:b215626830 . _:b215626993 "2"^^ . _:b215626825 . _:b215626992 "2"^^ . . _:b215626347 . _:b215626824 . _:b215627089 . _:b215626995 "2"^^ . _:b215626827 . _:b215627591 . _:b215626196 . _:b215626994 "2"^^ . _:b215626373 . _:b116042 "be related to the functional capacity of these cells to inhibit the development of autoimmune effector cells as IL-2 \u2212/\u2212, IL-2R \u03B2-chain (CD122)\u2212/\u2212, and CD25\u2212/\u2212 mice develop multiple manifestations of inflammatory autoimmune diseases (>>28<<\u201331). These studies suggest that IL-2 itself may either directly or indirectly play an important role in the development and/or function of this unique population of CD25+ suppressor cells." . _:b215627185 . _:b215626826 . _:b215626880 . _:b215627005 "2"^^ . _:b215626837 . _:b215627004 "2"^^ . _:b215626680 . . _:b215626977 . _:b215626836 . _:b215627007 "2"^^ . _:b215626336 . _:b215626839 . _:b215627006 "2"^^ . _:b215627099 . . _:b215626838 . _:b215627001 "2"^^ . _:b215626987 . _:b215625903 . _:b215626833 . _:b215627000 "2"^^ . _:b215625898 . _:b215626832 . _:b215627003 "2"^^ . . _:b215626835 . _:b215627002 "2"^^ . _:b215627715 . _:b215626834 . _:b215626532 . _:b215627013 "2"^^ . _:b215626845 . _:b215627012 "2"^^ . _:b215626844 . _:b215626197 . _:b215627015 "2"^^ . _:b215626847 . _:b215627014 "2"^^ . _:b215626846 . _:b215627009 "2"^^ . . _:b215626208 . _:b215627102 . _:b215626841 . _:b215627008 "2"^^ . _:b215626840 . _:b215627011 "2"^^ . . _:b215626843 . _:b215627010 "2"^^ . . _:b215626842 . _:b215627021 "2"^^ . _:b215627546 . _:b215626853 . _:b215627020 "2"^^ . _:b215626852 . _:b215627023 "2"^^ . _:b215626855 . . _:b215627022 "2"^^ . _:b215626854 . _:b215627017 "2"^^ . _:b215627738 . _:b215626849 . _:b215627016 "2"^^ . _:b215626848 . _:b215627019 "2"^^ . . _:b215626851 . _:b215627018 "2"^^ . . . _:b215626850 . _:b215627029 "2"^^ . _:b215626861 . _:b215627028 "2"^^ . _:b215626860 . _:b215627031 "2"^^ . _:b215626863 . _:b215627030 "2"^^ . _:b215626862 . . _:b215627025 "2"^^ . . _:b215626857 . . . _:b215627024 "2"^^ . _:b215626856 . _:b215627027 "2"^^ . _:b215626859 . _:b215627026 "2"^^ . _:b215626545 . _:b215627686 . _:b215626580 . _:b215626925 . _:b215626858 . _:b215627037 "2"^^ . _:b215626869 . . _:b215627036 "2"^^ . . _:b215626868 . _:b215627039 "2"^^ . . _:b215626249 . _:b215626871 . _:b215625835 . _:b215627038 "2"^^ . _:b215626151 . _:b215626870 . _:b215626363 . _:b215627033 "2"^^ . _:b215626662 . . _:b215626865 . _:b215626860 . _:b215627032 "2"^^ . . _:b215626913 . _:b215626153 . _:b215626792 . _:b215626864 . _:b215627035 "2"^^ . _:b215626867 . _:b215627034 "2"^^ . _:b215626866 . _:b215627045 "2"^^ . . . _:b215626877 . _:b215627044 "2"^^ . . _:b215627233 . _:b215626876 . _:b215627047 "2"^^ . _:b215626879 . _:b215627046 "2"^^ . _:b215626878 . _:b215627041 "2"^^ . . . _:b215626873 . . _:b215627040 "2"^^ . _:b215625953 . _:b215626872 . _:b215626841 . _:b215627043 "2"^^ . _:b215627080 . _:b215626875 . _:b215627042 "2"^^ . _:b215627287 . _:b215626874 . _:b215627053 "2"^^ . . . _:b215626885 . _:b215627052 "2"^^ . _:b215625895 . _:b215626884 . _:b215627055 "2"^^ . . _:b215626887 . _:b215627054 "2"^^ . . _:b215626886 . _:b215627049 "2"^^ . _:b215626403 . _:b215626881 . _:b215626313 . _:b215627048 "2"^^ . . _:b215626880 . _:b215627051 "2"^^ . . . _:b215626883 . . _:b215627050 "2"^^ . _:b215626499 . . _:b215626765 . _:b215627371 . _:b215626882 . _:b215627061 "2"^^ . . . _:b215626893 . _:b215627060 "2"^^ . _:b215626892 . _:b215627063 "2"^^ . _:b215626895 . _:b215627062 "2"^^ . _:b215626894 . _:b215627057 "2"^^ . _:b215626586 . _:b215627244 . _:b215626889 . _:b215627733 . . _:b215627056 "2"^^ . . _:b215626888 . _:b215627059 "2"^^ . . . _:b215626891 . _:b215627058 "2"^^ . . _:b215626890 . _:b215627069 "2"^^ . _:b215626901 . _:b215627329 . _:b215627068 "2"^^ . _:b215626900 . _:b215627071 "2"^^ . _:b215626903 . _:b215627070 "2"^^ . _:b215626902 . _:b215627065 "2"^^ . _:b215626283 . . . _:b215626897 . _:b215627064 "2"^^ . _:b215626896 . _:b215627067 "2"^^ . _:b215627413 . _:b215626899 . _:b215627066 "2"^^ . . . _:b215626898 . . _:b215627077 "2"^^ . _:b215626909 . _:b215627076 "2"^^ . . . _:b215626908 . _:b215627079 "2"^^ . _:b215625978 . . _:b215626911 . _:b215627078 "2"^^ . . _:b215625845 . _:b215626910 . _:b215627073 "2"^^ . _:b215626905 . _:b215627072 "2"^^ . _:b215626795 . _:b215627463 . _:b215626904 . _:b215627075 "2"^^ . _:b215625891 . . _:b215626907 . . _:b215627074 "2"^^ . . _:b215626906 . _:b215627085 "2"^^ . _:b215626472 . _:b215626917 . _:b215627084 "2"^^ . . _:b215626916 . _:b215627474 . _:b215627087 "2"^^ . . . _:b215626919 . _:b215627086 "2"^^ . . . _:b215626687 . _:b215626918 . _:b215627081 "2"^^ . _:b215626913 . _:b215627195 . _:b215627080 "2"^^ . . _:b215627488 . _:b215626912 . _:b215626649 . _:b215627424 . _:b215627083 "2"^^ . . . _:b215626915 . _:b215626135 . _:b215627082 "2"^^ . _:b215626540 . . _:b215626914 . _:b215627093 "2"^^ . _:b215627529 . _:b116043 . _:b215627635 . _:b215626925 . _:b215627092 "2"^^ . . _:b215626881 . _:b215626924 . _:b215626141 . _:b215627095 "2"^^ . _:b215626927 . _:b215627094 "2"^^ . _:b215626926 . _:b215627089 "2"^^ . . _:b215626921 . _:b215627088 "2"^^ . _:b215626920 . _:b215627091 "2"^^ . _:b215626923 . _:b215626567 . _:b215627090 "2"^^ . . _:b215626922 . _:b215627101 "2"^^ . _:b215626264 . _:b215626933 . . _:b215627100 "2"^^ . _:b215627206 . _:b215626932 . _:b215627103 "2"^^ . _:b215626652 . _:b215626935 . _:b215627102 "2"^^ . . _:b215627411 . _:b215626934 . _:b215627097 "2"^^ . _:b215626974 . _:b215627056 . _:b215626929 . . _:b215627096 "2"^^ . _:b215626928 . _:b215627099 "2"^^ . _:b215627208 . _:b215626931 . _:b215627098 "2"^^ . _:b215627382 . _:b215626930 . _:b215627109 "2"^^ . _:b215626941 . . _:b215627108 "2"^^ . . _:b215626940 . _:b215627111 "2"^^ . _:b215626943 . _:b215626531 . _:b215627110 "2"^^ . _:b215626589 . _:b215626263 . _:b215626942 . _:b215627105 "2"^^ . _:b215626066 . _:b215626937 . _:b215627104 "2"^^ . _:b215626350 . . _:b215626936 . _:b215627107 "2"^^ . . _:b215626939 . _:b215627106 "2"^^ . _:b215626938 . _:b215627117 "2"^^ . _:b215627414 . . _:b215626949 . _:b215627116 "2"^^ . . _:b215626948 . _:b215627038 . _:b215627119 "2"^^ . _:b215626310 . _:b215626951 . _:b215627118 "2"^^ . _:b215626950 . . _:b215627113 "2"^^ . . _:b215626945 . _:b215627112 "2"^^ . _:b215627189 . _:b215626944 . _:b215627002 . _:b215627115 "2"^^ . _:b215626947 . . _:b215627114 "2"^^ . _:b215626946 . . _:b215627416 . _:b215627125 "2"^^ . . _:b215626037 . _:b215626957 . _:b215627124 "2"^^ . . _:b215626956 . . _:b215627127 "2"^^ . _:b215626959 . _:b215626523 . _:b215627126 "2"^^ . . _:b116042 . _:b215626958 . _:b215627121 "2"^^ . _:b215627316 . _:b215626953 . _:b215627120 "2"^^ . _:b215626952 . _:b215627123 "2"^^ . _:b215626955 . _:b215627122 "2"^^ . _:b215626954 . _:b215627133 "2"^^ . _:b215625961 . _:b215626931 . _:b215626965 . _:b215627132 "2"^^ . _:b215626787 . _:b215626964 . _:b215626443 . _:b215627135 "2"^^ . . . _:b215627664 . _:b215626967 . _:b215627134 "2"^^ . _:b215626966 . . _:b215627129 "2"^^ . . . _:b215626961 . _:b215627128 "2"^^ . _:b215627675 . _:b215626960 . _:b116032 "It has been postulated that the induction of autoimmunity after 3dTx is secondary to a deficiency of the CD4+ CD25+ population that develops later during ontogeny (>>13<<). Paradoxically, a greater percentage (25\u201330 versus 10%) of CD4+ T cells in 3dTx mice express CD25 compared with normal mice (18)." . _:b215627131 "2"^^ . _:b215626963 . _:b215627130 "2"^^ . . _:b215627326 . _:b215626962 . _:b215627141 "2"^^ . . _:b116042 . . _:b215626973 . _:b215627140 "2"^^ . . . _:b215626972 . _:b215627143 "2"^^ . _:b215626619 . . _:b215626975 . _:b215627142 "2"^^ . . _:b215626989 . _:b215626974 . _:b215627137 "2"^^ . . _:b215625872 . _:b215626969 . . _:b215627136 "2"^^ . _:b215626968 . _:b215627139 "2"^^ . . _:b215626971 . _:b215627138 "2"^^ . _:b215626003 . _:b215626970 . . _:b215627149 "2"^^ . . _:b215626981 . _:b215627148 "2"^^ . _:b215626337 . _:b215626980 . _:b215627151 "2"^^ . _:b215626885 . _:b215626983 . . _:b215627150 "2"^^ . . . _:b215626125 . _:b215626982 . _:b215627145 "2"^^ . _:b215626977 . _:b215627144 "2"^^ . _:b215626764 . _:b215626976 . _:b215627147 "2"^^ . _:b215626979 . _:b215627146 "2"^^ . _:b215627453 . _:b215626978 . _:b215627157 "2"^^ . _:b215627690 . _:b215626989 . _:b215625930 . _:b215627156 "2"^^ . _:b215626988 . _:b215627159 "2"^^ . . _:b215627070 . _:b215626991 . _:b215627158 "2"^^ . . _:b215626554 . _:b215626990 . . _:b215627153 "2"^^ . _:b215626985 . _:b215627152 "2"^^ . _:b215627587 . _:b215626984 . _:b215627155 "2"^^ . . . _:b215626987 . . _:b215627154 "2"^^ . _:b215626986 . _:b215626109 . _:b215627165 "2"^^ . _:b215626997 . _:b215627164 "2"^^ . . _:b215627558 . . _:b215626996 . _:b215627167 "2"^^ . _:b215626999 . _:b215627166 "2"^^ . _:b215626998 . _:b215627161 "2"^^ . _:b215626993 . . _:b215627340 . _:b215627160 "2"^^ . _:b215626992 . _:b215627163 "2"^^ . . . _:b215626995 . _:b215627162 "2"^^ . _:b215626448 . _:b215626994 . _:b215626489 . _:b215627173 "2"^^ . _:b215626710 . _:b215627005 . _:b215627172 "2"^^ . _:b215627004 . _:b215627175 "2"^^ . _:b215627077 . _:b215627007 . _:b215627174 "2"^^ . . . _:b215627006 . _:b215627169 "2"^^ . _:b215627001 . _:b215627168 "2"^^ . _:b215626447 . . _:b215627000 . _:b215627171 "2"^^ . _:b215626896 . _:b215627003 . _:b215627170 "2"^^ . . . _:b215627002 . _:b215627181 "2"^^ . . _:b215626501 . _:b215627180 "2"^^ . _:b215626500 . _:b215627521 . _:b215627183 "2"^^ . . _:b215626503 . . _:b215627182 "2"^^ . . . _:b215626502 . _:b215627177 "2"^^ . _:b215626497 . _:b215627176 "2"^^ . _:b215626496 . _:b215627179 "2"^^ . _:b215626707 . _:b215626499 . _:b215626675 . _:b215627178 "2"^^ . _:b215626498 . _:b215626496 . _:b215627189 "2"^^ . _:b215626509 . _:b215626400 . _:b215627188 "2"^^ . . _:b215626508 . . _:b215627191 "2"^^ . . _:b215626511 . _:b215627190 "2"^^ . _:b215626510 . _:b215627680 . _:b215627185 "2"^^ . . _:b215626505 . _:b215627184 "2"^^ . _:b215626504 . _:b215627187 "2"^^ . _:b215626507 . _:b215627186 "2"^^ . _:b215626506 . _:b215627197 "2"^^ . _:b215625837 . _:b215627470 . _:b215626517 . _:b215627196 "2"^^ . _:b215626633 . . _:b215626516 . _:b215627199 "2"^^ . . _:b215626519 . _:b215627198 "2"^^ . _:b215625839 . _:b215626173 . _:b215626218 . _:b215626518 . _:b215627193 "2"^^ . . . _:b215626513 . _:b215627192 "2"^^ . . _:b215626512 . _:b215627195 "2"^^ . _:b215626334 . _:b215626916 . . _:b215626515 . . . _:b215627194 "2"^^ . . _:b116029 "As previously reported (>>20<<), addition of either anti\u2013CTLA-4 or anti-CD40 had modest enhancing effects on the responses of the CD4+CD25\u2212 cells, but had no effects on the suppression of the responses by the CD4+CD25+ cells (Fig." . . _:b215626514 . _:b215627205 "2"^^ . . _:b215626525 . _:b215627204 "2"^^ . . _:b215626524 . _:b215627207 "2"^^ . _:b215626527 . _:b215626731 . _:b215627206 "2"^^ . . _:b215626526 . _:b215627004 . . _:b215627201 "2"^^ . _:b215626521 . . _:b215625847 . _:b215627200 "2"^^ . _:b215626520 . _:b215627203 "2"^^ . _:b215626523 . . . _:b215627202 "2"^^ . _:b215625879 . _:b215627112 . _:b215626522 . . _:b215627213 "2"^^ . . _:b215626238 . _:b215626533 . . _:b215627212 "2"^^ . _:b215626532 . . _:b215627723 . _:b215627215 "2"^^ . _:b215626535 . _:b215627214 "2"^^ . . _:b215626534 . _:b215627209 "2"^^ . . . _:b215626844 . _:b215626529 . _:b215625969 . _:b215627208 "2"^^ . _:b215625849 . _:b215626528 . _:b215627211 "2"^^ . _:b215627384 . _:b215627071 . _:b215626531 . . _:b215627210 "2"^^ . . _:b215626478 . . _:b215626530 . _:b215627221 "2"^^ . _:b215626541 . _:b215626934 . _:b215627220 "2"^^ . _:b215626295 . _:b215626540 . . _:b215627223 "2"^^ . _:b215626543 . _:b215627222 "2"^^ . _:b215626542 . _:b215626557 . _:b215627217 "2"^^ . . _:b215626537 . _:b215627216 "2"^^ . . _:b215626536 . _:b215627219 "2"^^ . _:b215626539 . _:b215627218 "2"^^ . . _:b215626538 . _:b215626536 . _:b215626254 . . _:b215627229 "2"^^ . . _:b215627421 . . _:b215626549 . _:b215627228 "2"^^ . _:b215626548 . _:b215627231 "2"^^ . . _:b215626551 . _:b215626442 . _:b215627230 "2"^^ . . _:b215626550 . _:b215627225 "2"^^ . _:b215627264 . _:b215626545 . _:b215626257 . _:b215627224 "2"^^ . . _:b215626544 . _:b215627227 "2"^^ . _:b215626547 . _:b215627731 . _:b215627226 "2"^^ . . _:b215626605 . _:b215626546 . _:b215627237 "2"^^ . _:b215626557 . _:b215627236 "2"^^ . _:b215626556 . _:b215627239 "2"^^ . . _:b215626559 . _:b215626993 . _:b215627238 "2"^^ . . _:b215626558 . _:b215627233 "2"^^ . _:b215627722 . _:b215626611 . . _:b215626556 . . _:b215626553 . _:b215627232 "2"^^ . _:b215627306 . _:b215626552 . _:b215627235 "2"^^ . . _:b215626555 . _:b215627234 "2"^^ . _:b215626554 . _:b215627245 "2"^^ . _:b215626565 . . _:b215627244 "2"^^ . _:b215626833 . . . _:b215626564 . _:b215627247 "2"^^ . _:b215626567 . _:b215627246 "2"^^ . _:b215626824 . _:b215626566 . _:b215625853 . _:b215627241 "2"^^ . _:b215626944 . . _:b116035 "The concept of antigen-specific suppressor factors that acted in a complex cascade has not been validated by biochemical and molecular studies (>>21<<). Many of the older in vivo studies on the activity of suppressor cells have been reinterpreted as being secondary to alterations in the Th1\u2013Th2 balance that was induced by different modes of antigen delivery. Most recent data on the" . . _:b215626561 . _:b215627240 "2"^^ . . _:b215627401 . _:b215626560 . _:b215627243 "2"^^ . _:b215626563 . _:b215627242 "2"^^ . . _:b215626562 . _:b215627253 "2"^^ . . _:b215626573 . . _:b215627252 "2"^^ . . _:b215626572 . . _:b215627255 "2"^^ . _:b215626575 . _:b215627254 "2"^^ . _:b215626574 . _:b215627249 "2"^^ . . _:b215626569 . _:b215627248 "2"^^ . _:b116046 . _:b215626568 . . _:b215627251 "2"^^ . . _:b215626571 . . _:b215627250 "2"^^ . _:b215626570 . _:b215627261 "2"^^ . _:b215626581 . _:b215627260 "2"^^ . _:b215627745 . _:b215626424 . _:b215626580 . _:b215627263 "2"^^ . . _:b215626583 . _:b215627739 . . _:b215627262 "2"^^ . _:b215626582 . _:b215627257 "2"^^ . _:b215627391 . _:b215627168 . _:b215626577 . _:b215627256 "2"^^ . _:b215627702 . _:b215626576 . _:b215627259 "2"^^ . . _:b215626579 . . _:b215627502 . _:b215627258 "2"^^ . _:b215626578 . _:b215626245 "4"^^ . _:b215626589 . . _:b215626692 . _:b215626244 "4"^^ . . _:b215627248 . _:b215626588 . _:b215626247 "4"^^ . _:b215626591 . _:b215626246 "4"^^ . _:b215626590 . _:b215626241 "4"^^ . _:b215626354 . _:b215625944 . _:b215626585 . . _:b215626590 . _:b215626917 . . . _:b215626240 "5"^^ . _:b215626584 . _:b215626243 "4"^^ . _:b215626587 . _:b215626242 "4"^^ . _:b215626586 . _:b215627351 . _:b215626253 "4"^^ . _:b215626597 . . . _:b215626252 "4"^^ . _:b215625886 . _:b215626596 . _:b215626255 "4"^^ . . _:b215626599 . _:b215626254 "4"^^ . _:b215626598 . . _:b215626249 "4"^^ . . _:b215626593 . _:b215627448 . _:b215626248 "4"^^ . _:b215626592 . . _:b215626251 "4"^^ . . _:b215626595 . _:b215626250 "4"^^ . _:b215626594 . _:b215626796 . _:b215626261 "4"^^ . _:b215627428 . _:b215626605 . _:b215626260 "4"^^ . _:b215626604 . . _:b215626263 "4"^^ . . _:b215626607 . . _:b215626262 "4"^^ . _:b215626606 . _:b215626257 "4"^^ . . _:b215626601 . _:b215626256 "4"^^ . _:b215627345 . _:b215626600 . . _:b215626685 . _:b215626259 "4"^^ . _:b215626603 . _:b215626258 "4"^^ . _:b215626271 . _:b215626602 . _:b215627550 . _:b215626269 "4"^^ . _:b215626613 . . _:b215627159 . . _:b215626268 "4"^^ . _:b215626612 . _:b215626271 "4"^^ . _:b215626194 . _:b215626615 . . _:b215626721 . _:b215626270 "4"^^ . _:b215625994 . _:b215626614 . . _:b215626265 "4"^^ . _:b215626609 . _:b215627630 . _:b215626200 . . _:b215626101 . _:b215627642 . _:b215626264 "4"^^ . _:b215626127 . _:b215626608 . . . _:b215626267 "4"^^ . _:b215626611 . . _:b215626266 "4"^^ . . _:b215626610 . _:b215626190 . . _:b215626284 . . _:b215626277 "4"^^ . . _:b215626621 . _:b215625866 . _:b215626276 "4"^^ . . _:b215626620 . . . _:b215626192 . . _:b215626279 "4"^^ . . . . _:b215626623 . . _:b215626435 . _:b215626278 "4"^^ . . _:b215626622 . . _:b215626273 "4"^^ . _:b215626617 . . _:b215627505 . _:b215627037 . _:b215626272 "4"^^ . _:b215626616 . _:b215626275 "4"^^ . _:b215626619 . _:b215626837 . _:b215626274 "4"^^ . . _:b215626618 . _:b215626050 . . . . _:b215626285 "4"^^ . _:b215626629 . _:b215627122 . _:b215626284 "4"^^ . _:b215626628 . . _:b215626577 . _:b215626287 "4"^^ . _:b215626631 . _:b215626286 "4"^^ . _:b215626630 . _:b215626369 . _:b215626010 . _:b215626281 "4"^^ . _:b215626625 . _:b215626280 "4"^^ . . . _:b215626624 . . _:b215626136 . . . _:b215626283 "4"^^ . . _:b215626627 . . _:b215626282 "4"^^ . _:b215626626 . _:b215626245 . _:b215626293 "4"^^ . _:b215627013 . _:b215626637 . _:b215626292 "4"^^ . . _:b215626636 . _:b215626713 . _:b215626250 . . _:b215626295 "4"^^ . _:b215627377 . . _:b215626639 . _:b215626665 . _:b215626294 "4"^^ . _:b215626638 . _:b215627743 . _:b215626289 "4"^^ . _:b215626633 . _:b215626288 "4"^^ . _:b215626051 . _:b215626632 . _:b215626291 "4"^^ . _:b215626184 . _:b215626635 . _:b215625910 . _:b215626290 "4"^^ . _:b215626634 . . _:b215626301 "4"^^ . _:b215626645 . _:b215627065 . _:b215627457 . . _:b215626300 "4"^^ . _:b215626644 . _:b215627261 . . . _:b215627455 . _:b215626303 "4"^^ . . . _:b215626647 . _:b215627061 . _:b215627392 . _:b215626302 "4"^^ . . _:b215626646 . _:b215626469 . _:b215626297 "4"^^ . _:b215626641 . _:b215627368 . _:b215627092 . _:b215626296 "4"^^ . _:b215627224 . _:b215626640 . . _:b215627649 . _:b215626299 "4"^^ . . _:b215626643 . . . _:b215626298 "4"^^ . _:b215626642 . . _:b215626309 "4"^^ . _:b215626653 . _:b215626308 "4"^^ . _:b215626652 . _:b215625860 . _:b215626311 "4"^^ . . _:b215626655 . _:b215626310 "4"^^ . . _:b215626654 . _:b215627212 . . _:b215626305 "4"^^ . . _:b215626649 . _:b215626304 "4"^^ . _:b215626648 . _:b215626307 "4"^^ . _:b215626622 . _:b215626651 . _:b215626128 . _:b215626306 "4"^^ . _:b215626650 . . . _:b215627029 . _:b215626317 "4"^^ . _:b215626661 . _:b215626316 "4"^^ . _:b215626307 . . _:b215626660 . . _:b215626319 "4"^^ . _:b215626663 . _:b215626318 "4"^^ . _:b215627078 . _:b215626662 . . _:b215626313 "4"^^ . _:b215626657 . _:b215627105 . _:b215626312 "4"^^ . _:b215626656 . _:b215626315 "4"^^ . . _:b215626103 . _:b215626659 . _:b215626314 "4"^^ . . _:b215626658 . . . _:b215626325 "4"^^ . _:b215626669 . _:b215625989 . _:b215626324 "4"^^ . _:b215626628 . _:b215626668 . . _:b215626122 . _:b215626327 "4"^^ . _:b215626671 . . . _:b215626326 "4"^^ . . _:b215626670 . . . _:b215626321 "4"^^ . _:b215626665 . _:b215626320 "4"^^ . _:b215626664 . _:b215627118 . _:b215626276 . _:b215626826 . _:b215626323 "4"^^ . . _:b215626667 . _:b215626322 "4"^^ . _:b215626666 . _:b215626333 "4"^^ . _:b116047 "of the regulatory cells in the models where lymphopenic animals are reconstituted with CD45RBlow cells although it has been proposed that the T cells that mediate dominant tolerance recognize the autoantigen or peptides derived from it (>>36<<) and that both the effector and suppressor repertoires are generated in the thymus." . . _:b215626677 . . _:b215626332 "4"^^ . _:b215627084 . . _:b215626676 . _:b215625885 . _:b215626335 "4"^^ . _:b215626679 . _:b215626501 . . _:b215626334 "4"^^ . _:b215626678 . _:b215626329 "4"^^ . . _:b215626673 . _:b215626328 "4"^^ . _:b215626266 . _:b215626672 . . _:b215626410 . _:b215626331 "4"^^ . _:b215626675 . . _:b215627012 . _:b215626330 "4"^^ . _:b215626674 . _:b215626341 "4"^^ . _:b215626685 . _:b215626340 "4"^^ . _:b215626684 . _:b215626343 "4"^^ . _:b215626687 . _:b215626757 . _:b215626342 "4"^^ . . _:b215626686 . . _:b215626374 . _:b215626546 . _:b215626337 "4"^^ . . _:b215626681 . _:b215626539 . _:b215626336 "4"^^ . . _:b215626680 . . _:b215627040 . _:b215626339 "4"^^ . _:b215626683 . _:b215626338 "4"^^ . . _:b215626682 . _:b215626349 "4"^^ . _:b215626693 . . _:b215626348 "4"^^ . _:b215626692 . . _:b215626351 "4"^^ . _:b215626007 . _:b215627249 . _:b215626695 . _:b215626350 "4"^^ . . _:b215626694 . _:b215626017 . _:b215626345 "4"^^ . _:b215626781 . _:b215626689 . . _:b215627283 . . _:b215626344 "4"^^ . . _:b215626688 . _:b215626199 . . . _:b215626347 "4"^^ . _:b116026 . _:b215626691 . _:b215626346 "4"^^ . _:b215626690 . . _:b215625888 . . _:b116022 . _:b215626357 "4"^^ . _:b215626701 . _:b215627124 . . _:b215626356 "4"^^ . _:b215626700 . _:b215626359 "4"^^ . . _:b215626703 . _:b215626475 . _:b215626358 "4"^^ . _:b116027 . _:b215626702 . _:b215626353 "4"^^ . _:b215626697 . _:b116034 . _:b215626352 "4"^^ . . _:b215626696 . _:b215626355 "4"^^ . _:b215626367 . _:b215626699 . _:b215626354 "4"^^ . _:b215626698 . _:b215627626 . _:b215626967 . _:b215626365 "4"^^ . _:b215626709 . _:b215626217 . _:b215626364 "4"^^ . _:b215626708 . _:b215626367 "4"^^ . _:b215626711 . _:b215626366 "4"^^ . . _:b116037 . _:b215626710 . . _:b215626361 "4"^^ . _:b215626705 . _:b215627066 . _:b215626360 "4"^^ . _:b215626704 . _:b215627632 . . _:b215625972 . _:b215626542 . _:b215626363 "4"^^ . _:b215626707 . _:b215626877 . _:b215626362 "4"^^ . _:b215626706 . _:b215626852 . _:b215626134 . _:b215627011 . _:b215626373 "4"^^ . _:b215627251 . . _:b215626717 . _:b215626372 "4"^^ . _:b215626716 . _:b215627155 . . _:b215626871 . _:b215626375 "4"^^ . _:b215626719 . _:b215626374 "4"^^ . _:b215626718 . _:b215626369 "4"^^ . _:b215626713 . _:b215626734 . . . _:b215626368 "4"^^ . . _:b215626712 . _:b215627694 . _:b215626371 "4"^^ . . _:b215626715 . _:b215627260 . _:b215626370 "4"^^ . _:b215626714 . _:b215626381 "4"^^ . . _:b215626725 . . _:b215626380 "4"^^ . _:b215626059 . _:b215626724 . . . _:b215626383 "4"^^ . _:b215626928 . _:b215626362 . _:b215626727 . . . _:b215626779 . _:b215626382 "4"^^ . _:b215626726 . . . _:b215626377 "4"^^ . _:b215626721 . _:b215626552 . _:b215627374 . _:b215626376 "4"^^ . _:b215626720 . _:b215626193 . _:b215626379 "4"^^ . _:b215627136 . . _:b215626723 . . _:b215626378 "4"^^ . . _:b215627196 . _:b215626722 . _:b215626389 "4"^^ . _:b215626733 . _:b215626388 "4"^^ . . _:b215627128 . _:b215626732 . _:b215626391 "4"^^ . _:b215626735 . _:b215626004 . _:b215626390 "4"^^ . _:b215626734 . _:b215626385 "4"^^ . . _:b215626729 . _:b215626627 . _:b215626423 . _:b215626384 "4"^^ . _:b215626728 . _:b215626387 "4"^^ . _:b215626731 . . . _:b215626386 "4"^^ . _:b215626730 . _:b215626229 . _:b215626397 "4"^^ . _:b215627720 . _:b215626741 . _:b215626396 "4"^^ . _:b215626740 . _:b215626807 . _:b215626399 "4"^^ . _:b215626743 . _:b215627319 . _:b215626398 "4"^^ . _:b215626742 . _:b215626393 "4"^^ . _:b215626737 . _:b215627383 . _:b215626392 "4"^^ . _:b215626736 . _:b215627064 . _:b215626395 "4"^^ . _:b215626739 . _:b215625985 . _:b215626394 "4"^^ . _:b215626659 . _:b215626738 . . _:b215626405 "4"^^ . _:b215626749 . . _:b215626631 . . _:b215626570 . _:b215626404 "4"^^ . . _:b215626748 . . _:b215626407 "4"^^ . _:b215626751 . _:b215626406 "4"^^ . _:b215626750 . _:b215626115 . _:b215626614 . _:b215626401 "4"^^ . _:b215626745 . _:b215626400 "4"^^ . . _:b215626744 . _:b215626403 "4"^^ . _:b215626747 . . _:b215626402 "4"^^ . _:b215626746 . _:b215625855 . _:b215627359 . _:b215626413 "4"^^ . _:b215626245 . . _:b215626412 "4"^^ . _:b215627358 . _:b215627101 . . _:b215626244 . . . . _:b215626625 . _:b215626415 "4"^^ . _:b215626247 . _:b215627242 . _:b215626414 "4"^^ . _:b215626246 . _:b215626279 . . _:b215626409 "4"^^ . _:b215626241 . _:b215626408 "4"^^ . _:b215626240 . _:b215626411 "4"^^ . _:b215626243 . _:b215626749 . _:b215626914 . _:b215626410 "4"^^ . _:b215626242 . . _:b215626421 "4"^^ . _:b215626253 . _:b215626420 "4"^^ . _:b215626252 . _:b215626686 . . _:b215626119 . _:b215626423 "4"^^ . _:b215626255 . _:b215626001 . _:b215626422 "4"^^ . _:b215626254 . _:b116050 . _:b215626417 "4"^^ . _:b215626572 . _:b215626249 . _:b215626466 . . _:b215626416 "4"^^ . _:b215626248 . . _:b215626419 "4"^^ . _:b215626251 . _:b215626870 . _:b215626418 "4"^^ . _:b215627227 . _:b215627014 . _:b215626561 . _:b215626250 . _:b215627422 . _:b215625931 . _:b215626429 "3"^^ . _:b215626261 . _:b215626428 "3"^^ . . _:b215626888 . _:b215626260 . _:b215626431 "3"^^ . _:b215626263 . _:b215626430 "3"^^ . _:b215627404 . _:b215626130 . _:b215626262 . _:b215626745 . _:b215626425 "3"^^ . _:b215626257 . _:b215626424 "4"^^ . _:b215626954 . _:b215626256 . _:b215626019 . _:b215626427 "3"^^ . _:b215626983 . . _:b215626259 . _:b215626426 "3"^^ . _:b215626258 . _:b215626626 . _:b215625843 . _:b215626437 "3"^^ . _:b215626269 . _:b215625841 . _:b215626436 "3"^^ . _:b215626378 . _:b215626268 . _:b215626646 . _:b215626439 "3"^^ . . _:b215626657 . _:b215626271 . _:b215626650 . _:b215626324 . . _:b215626438 "3"^^ . _:b215626270 . _:b215626433 "3"^^ . _:b215626166 . _:b215626265 . _:b215626432 "3"^^ . _:b215626264 . _:b215626809 . _:b215626435 "3"^^ . _:b215626267 . _:b215626434 "3"^^ . _:b215626677 . _:b215626266 . . _:b215626445 "3"^^ . _:b215627156 . _:b215626277 . _:b215626444 "3"^^ . _:b215626276 . _:b215625948 . _:b215626447 "3"^^ . _:b215626279 . . _:b215626446 "3"^^ . _:b215626278 . _:b215626441 "3"^^ . _:b215626118 . _:b215626273 . _:b215626158 . _:b215626440 "3"^^ . _:b215626272 . . _:b215626443 "3"^^ . . . _:b215626275 . . _:b116026 "For ELISAs, supernatants were taken at the indicated times and IL-2 was quantified as previously described (>>19<<) using JES6-1A12 as the capture antibody and JES6-5H4 as the detection antibody." . _:b215626442 "3"^^ . _:b215626274 . _:b215626453 "3"^^ . _:b215626285 . _:b215627497 . _:b215626452 "3"^^ . . _:b215626284 . _:b215626455 "3"^^ . _:b215626924 . . _:b215626982 . _:b215626287 . _:b215626454 "3"^^ . . _:b215626286 . . _:b215626449 "3"^^ . _:b215626281 . _:b215626288 . _:b215626448 "3"^^ . _:b215626280 . _:b215626451 "3"^^ . . _:b215626283 . _:b215627489 . _:b215626450 "3"^^ . _:b215627373 . _:b215626282 . _:b215626014 . _:b215626461 "3"^^ . _:b215626293 . . _:b215626460 "3"^^ . _:b215626804 . _:b215626292 . _:b215626463 "3"^^ . _:b116027 "results" . _:b215626295 . _:b215626462 "3"^^ . . _:b215627611 . _:b215626294 . "PMC0" . _:b215626457 "3"^^ . _:b215626581 . _:b215626289 . . _:b215626456 "3"^^ . . . _:b215626288 . _:b215626459 "3"^^ . _:b215626291 . _:b215626696 . _:b215626458 "3"^^ . . _:b215626290 . _:b215626469 "3"^^ . _:b215626301 . . _:b215626468 "3"^^ . _:b215626300 . _:b215627107 . . _:b215626471 "3"^^ . _:b215626793 . . _:b215627467 . _:b215626303 . _:b215626470 "3"^^ . _:b215627276 . . _:b215626302 . _:b215626465 "3"^^ . _:b215627443 . . . _:b215626297 . _:b215627215 . . _:b215626464 "3"^^ . _:b215626296 . _:b215626467 "3"^^ . _:b215626299 . _:b215626466 "3"^^ . _:b215626298 . _:b215626477 "3"^^ . . _:b215626309 . _:b215626476 "3"^^ . _:b215626308 . _:b215626479 "3"^^ . _:b215626285 . _:b215626311 . _:b215626478 "3"^^ . _:b215627286 . _:b215626310 . . _:b215626473 "3"^^ . . _:b215626305 . _:b215626472 "3"^^ . . _:b215626304 . _:b215626683 . _:b215626475 "3"^^ . _:b215626755 . . _:b215626307 . . _:b215626474 "3"^^ . _:b215626306 . _:b215626485 "3"^^ . . _:b215626068 . _:b215626317 . _:b215626850 . _:b215627347 . . _:b215626484 "3"^^ . . _:b215626316 . _:b215626487 "3"^^ . . _:b215627461 . _:b215626319 . _:b215627459 . _:b215626486 "3"^^ . _:b215626318 . _:b215627068 . _:b215626274 . _:b215626481 "3"^^ . _:b215626313 . _:b215626782 . _:b215626480 "3"^^ . _:b215626312 . . _:b215626483 "3"^^ . _:b215626315 . _:b215626482 "3"^^ . _:b215626314 . _:b215627176 . . _:b215626493 "3"^^ . _:b215626487 . _:b215626325 . . _:b215626492 "3"^^ . _:b215626324 . _:b215626495 "3"^^ . _:b215627197 . _:b215626846 . _:b215626327 . . _:b215626432 . _:b215627456 . _:b215626494 "3"^^ . _:b215626262 . _:b215626326 . _:b215626489 "3"^^ . . . _:b215626321 . _:b215626488 "3"^^ . _:b215626810 . _:b215626320 . _:b215626491 "3"^^ . _:b215626058 . _:b215626323 . . _:b215626490 "3"^^ . _:b215627239 . _:b215626322 . . _:b215626549 . . . _:b215626501 "3"^^ . _:b215627418 . . _:b215626333 . _:b215625852 . _:b215626845 . _:b215626500 "3"^^ . . _:b215626332 . . _:b215626576 . _:b215627202 . _:b215626503 "3"^^ . . _:b215627597 . _:b215626878 . _:b215626335 . _:b215626502 "3"^^ . _:b215626992 . _:b215626334 . . _:b215627523 . _:b215626497 "3"^^ . _:b215626329 . . _:b215626496 "3"^^ . _:b215626328 . . . _:b215626499 "3"^^ . _:b215626331 . _:b215626498 "3"^^ . _:b215627517 . _:b215626330 . . _:b215626185 . _:b215626509 "3"^^ . _:b215626341 . _:b215627644 . _:b215626508 "3"^^ . _:b215626340 . _:b215626511 "3"^^ . _:b215626343 . _:b215627031 . _:b215626210 . _:b215626510 "3"^^ . _:b215626342 . _:b215626505 "3"^^ . _:b215626337 . _:b215626519 . _:b215626504 "3"^^ . _:b215626336 . _:b215626507 "3"^^ . _:b116048 . . _:b215626248 . _:b215626339 . . _:b215626506 "3"^^ . _:b215625875 . _:b215626233 . _:b215626338 . _:b215626702 . _:b215626517 "3"^^ . . _:b215626349 . _:b215626964 . _:b215626516 "3"^^ . . _:b215626348 . . _:b215626519 "3"^^ . _:b215626351 . . _:b215626518 "3"^^ . _:b215626814 . _:b215626350 . . _:b215626513 "3"^^ . . _:b215626648 . . _:b215626345 . _:b215626512 "3"^^ . _:b215626517 . _:b215626344 . _:b215626578 . . _:b215626515 "3"^^ . . . _:b215626305 . _:b215626347 . . _:b215626514 "3"^^ . _:b215626346 . _:b215626525 "3"^^ . _:b215626357 . . _:b215627651 . . _:b215626524 "3"^^ . . _:b215626356 . _:b215626527 "3"^^ . _:b215626359 . _:b215626526 "3"^^ . _:b215626358 . _:b215626521 "3"^^ . _:b215626353 . _:b215626520 "3"^^ . _:b215626758 . _:b215626111 . _:b215626585 . _:b215626352 . _:b215626523 "3"^^ . _:b215626355 . _:b215626522 "3"^^ . . . _:b215626354 . . _:b215626533 "3"^^ . _:b215626365 . . _:b215626532 "3"^^ . _:b215626364 . _:b215626535 "3"^^ . . _:b215626367 . _:b215627134 . _:b215626534 "3"^^ . _:b215626366 . _:b215626273 . _:b215627513 . . _:b215626529 "3"^^ . _:b215626361 . _:b215626528 "3"^^ . _:b215626902 . _:b215626360 . _:b215626531 "3"^^ . . _:b215627566 . _:b215626107 . . _:b215626363 . . _:b215627393 . . _:b215626530 "3"^^ . . _:b215627691 . _:b215626362 . _:b215626541 "3"^^ . _:b215626373 . _:b215626540 "3"^^ . . _:b215626905 . _:b215626372 . _:b215625968 . _:b215626543 "3"^^ . . _:b215626375 . _:b215626542 "3"^^ . _:b215626374 . _:b215626803 . _:b215626537 "3"^^ . . . _:b215626369 . . _:b215626536 "3"^^ . . _:b215626368 . . _:b215627578 . _:b215626539 "3"^^ . _:b215626563 . _:b215626371 . _:b215627221 . . _:b215626538 "3"^^ . _:b215625911 . _:b215626370 . . _:b215626549 "3"^^ . _:b215626381 . _:b215626548 "3"^^ . _:b215626380 . . _:b215626551 "3"^^ . _:b215625934 . _:b215626383 . _:b215626550 "3"^^ . _:b215626382 . _:b215626529 . _:b215626545 "3"^^ . . _:b215626377 . _:b215626544 "3"^^ . _:b215626376 . _:b215626547 "3"^^ . . _:b215626011 . _:b215626379 . _:b215626381 . _:b215626546 "3"^^ . _:b215626095 . _:b215626378 . _:b215626557 "3"^^ . _:b215626389 . _:b215627309 . _:b215626610 . _:b215626556 "3"^^ . _:b215626512 . _:b215626388 . . _:b215626559 "3"^^ . _:b215626391 . . _:b215626558 "3"^^ . _:b215627328 . _:b215626970 . . _:b215626775 . _:b215625890 . _:b215626390 . _:b215626553 "3"^^ . _:b215626385 . _:b215626552 "3"^^ . _:b215626929 . _:b215626384 . _:b215626555 "3"^^ . _:b215626387 . _:b215626554 "3"^^ . _:b215626386 . . _:b215626565 "3"^^ . . _:b215626820 . _:b215626397 . _:b215626564 "3"^^ . _:b215626087 . _:b215626396 . _:b215626567 "3"^^ . _:b215627732 . . _:b215626399 . . . _:b215626566 "3"^^ . _:b215626907 . _:b215626398 . _:b215625882 . . _:b215626561 "3"^^ . . _:b215627454 . . _:b215626393 . _:b215626560 "3"^^ . _:b215626392 . _:b215627294 . _:b215626563 "3"^^ . _:b215627490 . _:b215626395 . _:b215626562 "3"^^ . . _:b215627575 . _:b215626394 . . _:b215626530 . _:b215626366 . _:b215626573 "3"^^ . . . . _:b215626405 . . . _:b215626572 "3"^^ . _:b215626644 . _:b215626404 . . _:b215626575 "3"^^ . _:b215627616 . . _:b215626407 . _:b215626574 "3"^^ . _:b215627417 . _:b215626406 . _:b215627552 . _:b215626569 "3"^^ . _:b215626503 . . _:b215626401 . _:b215626568 "3"^^ . _:b215626654 . _:b215626400 . _:b215626571 "3"^^ . _:b215626403 . _:b116038 "The potential relationship of the CD4+CD25+ population to the CD45RBlow cells whose ability to protect animals from inflammatory bowel disease could be reversed by anti\u2013TGF-\u03B2 (>>24<<) and with TGF-\u03B2\u2013producing suppressor populations (the so-called Th3 cells) induced by oral delivery of antigen (25, 26) remains to be determined." . _:b215626570 "3"^^ . _:b215626333 . . _:b215626402 . _:b215626355 . . _:b215627548 . _:b215626581 "3"^^ . _:b215626413 . . _:b215626580 "3"^^ . _:b215626873 . _:b215626412 . . _:b215627058 . _:b215626583 "3"^^ . _:b215626415 . _:b215626582 "3"^^ . _:b215627427 . _:b215626414 . . _:b215626577 "3"^^ . _:b215626056 . _:b215627748 . _:b215626409 . _:b215626576 "3"^^ . _:b215626171 . _:b215626408 . _:b215626579 "3"^^ . . _:b215626411 . . _:b215626176 . _:b215626578 "3"^^ . _:b215625967 . _:b215626410 . . _:b215626589 "3"^^ . . _:b215626421 . _:b215626588 "3"^^ . _:b215626835 . . _:b215626420 . . . _:b215626591 "3"^^ . _:b215627688 . _:b215626423 . . _:b215626590 "3"^^ . _:b215626422 . . _:b215626585 "3"^^ . . . _:b215627324 . _:b215626417 . _:b215626584 "3"^^ . _:b215626416 . _:b215626587 "3"^^ . _:b215626419 . _:b215627388 . _:b215626586 "3"^^ . . _:b215626418 . . _:b215626597 "3"^^ . _:b215626429 . . _:b215626187 . _:b215626596 "3"^^ . _:b215626428 . _:b215626599 "3"^^ . _:b215625858 . _:b215626431 . _:b215626598 "3"^^ . _:b215626464 . _:b215626430 . _:b215627095 . _:b215626507 . _:b215626593 "3"^^ . _:b215626425 . _:b215626592 "3"^^ . . _:b215626424 . _:b215626595 "3"^^ . . _:b215626427 . . _:b215626594 "3"^^ . _:b215626031 . _:b215626426 . _:b215626605 "3"^^ . _:b215626437 . _:b215626604 "3"^^ . _:b215626436 . _:b215626898 . _:b215626607 "3"^^ . _:b215626997 . . _:b215626439 . _:b215626606 "3"^^ . _:b215626933 . _:b215626635 . . _:b215626438 . _:b215626601 "3"^^ . _:b215625876 . _:b215626433 . _:b215626600 "3"^^ . . _:b215626261 . _:b215626432 . _:b215627613 . . _:b215626603 "3"^^ . _:b215626435 . _:b215627526 . . _:b215626602 "3"^^ . . . _:b215626434 . _:b215626613 "3"^^ . . _:b215626445 . . _:b215626612 "3"^^ . _:b215627047 . . _:b215626444 . _:b215626615 "3"^^ . _:b215627716 . _:b215626447 . _:b215626614 "3"^^ . . _:b215626446 . _:b215626920 . . _:b215626609 "3"^^ . _:b215626441 . . _:b215626608 "3"^^ . . _:b215626440 . . . _:b215626611 "3"^^ . _:b215626443 . _:b215627658 . _:b215625834 . _:b215626610 "3"^^ . _:b215626442 . _:b215626621 "3"^^ . _:b215626453 . _:b215626620 "3"^^ . . _:b215626452 . . _:b215626323 . _:b215626623 "3"^^ . _:b215626455 . _:b215627685 . _:b215626622 "3"^^ . _:b215626454 . _:b215626617 "3"^^ . . _:b215626449 . . _:b215626616 "3"^^ . _:b215626448 . _:b215627444 . _:b215626275 . _:b215626619 "3"^^ . _:b215626451 . _:b215627504 . _:b215626618 "3"^^ . _:b215626450 . _:b215626629 "3"^^ . _:b215627114 . _:b215626461 . . _:b215626628 "3"^^ . _:b215627187 . _:b215626460 . _:b215627627 . _:b215626631 "3"^^ . _:b215627332 . _:b215626463 . _:b215626630 "3"^^ . _:b215626055 . _:b215626462 . _:b215626670 . _:b215626832 . _:b215627043 . _:b215626625 "3"^^ . _:b215626457 . _:b215626624 "3"^^ . _:b215625990 . _:b215626691 . _:b215626456 . _:b215626627 "3"^^ . . _:b215626459 . _:b215625977 . _:b215626626 "3"^^ . _:b215626458 . _:b215627536 . _:b215626637 "3"^^ . _:b215627390 . _:b215626469 . _:b215627512 . _:b215626636 "3"^^ . . _:b215626468 . . _:b215626639 "3"^^ . _:b215626471 . . _:b215626754 . . _:b215626638 "3"^^ . . _:b215626470 . _:b215626633 "3"^^ . _:b215626465 . _:b215626632 "3"^^ . _:b215626464 . . _:b215626635 "3"^^ . _:b215627154 . _:b215626467 . . _:b215625938 . . _:b215626634 "3"^^ . _:b215625873 . _:b215626466 . . _:b215626645 "3"^^ . . . _:b215627641 . _:b215627135 . _:b215626477 . . _:b215626644 "3"^^ . _:b215626476 . _:b215627237 . . _:b215626647 "3"^^ . _:b215626479 . . _:b215626646 "3"^^ . _:b215626478 . . _:b215626656 . _:b215626641 "3"^^ . _:b215626473 . . _:b215626640 "3"^^ . _:b215626472 . _:b215626228 . _:b215626643 "3"^^ . _:b215626475 . . . _:b215626642 "3"^^ . . _:b215627606 . . _:b215626474 . _:b215625940 . . _:b215626653 "3"^^ . _:b215626485 . _:b215627492 . _:b215626652 "3"^^ . _:b215627698 . . _:b215626484 . _:b215626655 "3"^^ . _:b215626951 . _:b215626487 . _:b215626189 . _:b215626654 "3"^^ . _:b215626486 . _:b215626649 "3"^^ . . _:b215627081 . _:b215626481 . . _:b215626648 "3"^^ . _:b215626398 . . _:b215626480 . . _:b215626651 "3"^^ . _:b215626483 . _:b215626650 "3"^^ . _:b215626482 . _:b215626694 . . . _:b215627355 . _:b215626828 . _:b215626661 "3"^^ . _:b215626493 . _:b215626660 "3"^^ . _:b215626073 . _:b215626470 . _:b215626492 . _:b215626663 "3"^^ . _:b215626325 . _:b215626495 . . _:b215626662 "3"^^ . . _:b215626494 . . _:b215626657 "3"^^ . _:b215626489 . . _:b215626656 "3"^^ . _:b215626488 . . _:b215626659 "3"^^ . . . . _:b215626491 . . _:b215626695 . . _:b215626658 "3"^^ . . _:b215626490 . . _:b215626669 "3"^^ . _:b215627469 . _:b215625989 . _:b215626668 "3"^^ . _:b215627603 . . _:b215625988 . . _:b215626671 "3"^^ . . _:b215625991 . . _:b215626131 . _:b215626670 "3"^^ . _:b215627398 . _:b215625990 . _:b215626665 "3"^^ . . _:b215625985 . . _:b215626664 "3"^^ . _:b215627182 . _:b215625984 . _:b215627270 . _:b215626667 "3"^^ . _:b215625987 . _:b215626666 "3"^^ . _:b215625986 . . _:b215626799 . . _:b215626243 . _:b215626677 "3"^^ . _:b215626457 . _:b215627267 . _:b215625997 . . _:b215626676 "3"^^ . _:b215625996 . . . _:b215626834 . _:b215626679 "3"^^ . . _:b215625999 . _:b215627700 . _:b215626678 "3"^^ . _:b215625998 . _:b215626673 "3"^^ . _:b215625993 . _:b215626234 . _:b215626672 "3"^^ . _:b215625992 . _:b215626675 "3"^^ . _:b215625995 . _:b215627683 . _:b215626674 "3"^^ . _:b215626855 . _:b215626746 . _:b215627545 . . _:b215625994 . . _:b215626685 "3"^^ . _:b215625844 . . _:b215626005 . . _:b215626684 "3"^^ . . . . _:b215626004 . _:b215626687 "3"^^ . . . _:b215626007 . _:b215626256 . . _:b215626686 "3"^^ . _:b215626006 . _:b215626681 "3"^^ . _:b215626001 . _:b215626680 "3"^^ . _:b215626000 . _:b215626683 "3"^^ . _:b215626003 . _:b215627188 . _:b215626682 "3"^^ . _:b215626002 . _:b215627297 . . _:b215627674 . _:b215626693 "3"^^ . _:b215626293 . _:b215626825 . _:b215626502 . _:b215626013 . _:b215626692 "3"^^ . _:b215626012 . _:b215626695 "3"^^ . _:b215627579 . . _:b215627005 . _:b215626015 . _:b215627577 . _:b215626694 "3"^^ . _:b215626014 . . _:b215626689 "3"^^ . _:b215626009 . . . . _:b215626688 "3"^^ . _:b215626008 . . . _:b215626691 "3"^^ . . _:b215626011 . _:b215626697 . _:b215625896 . . _:b215626690 "3"^^ . _:b215626010 . . _:b215626701 "3"^^ . _:b215626716 . _:b215626021 . . _:b215626700 "3"^^ . _:b215626020 . . _:b215626703 "3"^^ . _:b215626023 . _:b215626702 "3"^^ . _:b215627141 . _:b215626022 . _:b215626697 "3"^^ . _:b215626017 . _:b215626696 "3"^^ . _:b215627173 . _:b215626016 . . _:b215626699 "3"^^ . _:b215626019 . _:b215626698 "3"^^ . . _:b215626018 . _:b215626565 . _:b215626709 "3"^^ . . _:b215626029 . _:b215626900 . _:b215626708 "3"^^ . _:b215626028 . _:b215626711 "3"^^ . _:b215626031 . . . _:b215627542 . _:b215626712 . _:b215626710 "3"^^ . _:b215626030 . _:b215626688 . _:b215626705 "3"^^ . _:b215626025 . . _:b215626704 "3"^^ . _:b215626024 . . _:b215626707 "3"^^ . _:b215626027 . . . _:b215626706 "3"^^ . _:b215626026 . _:b215626717 "3"^^ . _:b215627079 . _:b215626037 . . _:b215627050 . _:b215626716 "3"^^ . _:b215626036 . _:b215626086 . . _:b215626719 "3"^^ . _:b215626039 . . _:b215626718 "3"^^ . _:b215626038 . . _:b215626713 "3"^^ . _:b215627307 . _:b215627623 . _:b215626033 . . _:b215626712 "3"^^ . . _:b215626032 . _:b215626092 . _:b215626715 "3"^^ . _:b215626035 . . . _:b215626714 "3"^^ . _:b215626034 . _:b215627389 . . _:b215627446 . . _:b215626725 "3"^^ . _:b215625958 . _:b215626045 . . . _:b215626724 "3"^^ . _:b215627203 . _:b215626044 . _:b215626727 "3"^^ . _:b215626047 . _:b215626726 "3"^^ . _:b215626046 . . _:b215626721 "3"^^ . _:b215626041 . _:b215626720 "3"^^ . _:b215626040 . _:b215626723 "3"^^ . _:b215626043 . _:b215626722 "3"^^ . . _:b215626042 . . _:b215626733 "3"^^ . _:b215626053 . _:b215626732 "3"^^ . _:b215627255 . _:b215626052 . _:b215627749 . _:b215626735 "3"^^ . _:b215626984 . _:b215626055 . . _:b215626308 . _:b215626734 "3"^^ . _:b215626054 . . . _:b215626729 "3"^^ . _:b215626049 . _:b215626728 "3"^^ . _:b215626356 . _:b215626048 . _:b215626214 . _:b215626731 "3"^^ . _:b215626102 . _:b215626051 . . _:b215627684 . . _:b215626730 "3"^^ . _:b215626050 . _:b215626741 "3"^^ . . _:b215626061 . _:b215626740 "3"^^ . _:b215626060 . _:b215626743 "3"^^ . . . _:b215625995 . _:b215626063 . . . _:b215625963 . _:b215626742 "3"^^ . _:b215626062 . _:b215626737 "3"^^ . _:b215626057 . _:b215626736 "3"^^ . _:b215626444 . _:b215626056 . . . _:b215626739 "3"^^ . _:b215626059 . _:b215626738 "3"^^ . _:b215626058 . _:b215626749 "3"^^ . _:b215626857 . _:b215626069 . . . _:b215627228 . _:b215626748 "3"^^ . . _:b215626068 . _:b215626751 "3"^^ . . _:b215626386 . _:b215626071 . . _:b215626750 "3"^^ . _:b215626070 . _:b215627705 . _:b215626745 "3"^^ . _:b215626065 . _:b215625838 . . . _:b215626776 . _:b215626744 "3"^^ . . _:b215626927 . _:b215626064 . _:b215626747 "3"^^ . _:b215626067 . _:b215626746 "3"^^ . _:b215626729 . _:b215626066 . _:b215626937 . . . _:b215626077 . . _:b215626076 . _:b116043 "Sakaguchi et al. (>>32<<) have proposed that any CD25+ cell, rather than a distinct, functional CD4+CD25+ subset, may mediate suppression." . . . _:b215626079 . _:b215626078 . _:b215626073 . _:b215626072 . _:b215626075 . _:b215626946 . . _:b215626074 . _:b215626085 . . _:b215626084 . . _:b215626791 . _:b215626087 . _:b215627051 . . _:b215626086 . . . _:b215626081 . _:b215626080 . _:b215627648 . . _:b215626083 . _:b215627076 . _:b215627062 . _:b215626082 . _:b215626093 . _:b215627662 . _:b215626856 . _:b215626760 . _:b215626092 . _:b215626095 . _:b215627530 . _:b215626094 . . _:b116040 . _:b215626089 . _:b215626484 . _:b215626088 . . . _:b215626091 . _:b215626476 . . _:b215625909 . _:b215626090 . . _:b215626101 . . . . _:b215626100 . _:b215626790 . _:b215626216 . _:b215626103 . _:b215627036 . _:b215626102 . _:b215626097 . _:b215627211 . _:b215626096 . _:b215626099 . _:b215625894 . . _:b215626098 . _:b215626930 . _:b215625927 . _:b215626109 . . _:b215626108 . _:b215626111 . _:b215626110 . . _:b215627400 . _:b215626105 . _:b215627172 . _:b215626534 . _:b215626104 . _:b215626183 . . _:b215626107 . _:b215626766 . . _:b215626106 . _:b215626035 . _:b215626753 . _:b215627605 . _:b215626117 . _:b215627204 . _:b215626908 . _:b215626116 . _:b215626119 . . _:b215626118 . _:b215627709 . _:b215626080 . . _:b215626113 . . _:b215627486 . _:b215626112 . . . . _:b215626115 . _:b215626091 . _:b215626114 . . _:b215626420 . . _:b215626125 . _:b215626875 . _:b215626124 . . _:b215626127 . . _:b215627338 . _:b215626812 . _:b215626126 . _:b215627341 . _:b215627520 . _:b215626121 . . _:b215627273 . _:b215626120 . _:b215626123 . _:b215626953 . _:b215626122 . . . . _:b215626133 . _:b215626329 . _:b215626132 . . . _:b215626135 . _:b215627207 . _:b215626134 . . _:b215626129 . _:b215627556 . . . _:b215626705 . _:b215626128 . . _:b215626474 . . _:b215626131 . _:b215626130 . _:b215627067 . _:b215626141 . _:b215626140 . . _:b215626143 . _:b215627740 . . . _:b215626142 . _:b215626137 . _:b215626136 . _:b215626139 . . _:b215626138 . _:b215626149 . _:b215626148 . _:b215626151 . _:b215627322 . _:b116050 "To a certain extent, our results resemble the observations of Lombardi et al. (>>39<<), who have shown that one mechanism by which anergic antigen-specific T cell clones inhibit proliferative responses of normal T cell clones in cocultures is by competition for antigen or costimulatory signals generated at the surface of" . _:b215627353 . _:b215626150 . . _:b215626145 . _:b215626144 . _:b215626668 . . _:b215626147 . _:b215627180 . _:b215626146 . _:b215627325 . _:b215626157 . _:b215627258 . . _:b215626156 . . _:b215626159 . . _:b215625951 . _:b215626158 . . _:b215626153 . _:b215626511 . _:b215625952 . _:b215626152 . _:b116041 . . _:b215626155 . _:b215626154 . _:b215626452 . _:b215626165 . . . _:b215626991 . _:b215626164 . _:b215626290 . _:b215626167 . _:b215627245 . _:b215626002 . _:b215625861 . _:b215626166 . _:b215626161 . . _:b215627555 . _:b215626160 . _:b215626163 . _:b215626162 . _:b215626173 . . _:b215626172 . . _:b215626175 . _:b215626879 . _:b215626067 . _:b215626174 . _:b215625848 "30"^^ . _:b215625901 . _:b215626169 . . _:b215625849 "30"^^ . _:b215627714 . _:b215626168 . . _:b215626171 . _:b215627549 . _:b215626170 . _:b215626181 . _:b215625844 "33"^^ . . . _:b215627375 . . _:b215627138 . _:b215626180 . _:b215625845 "33"^^ . . _:b215625846 "31"^^ . _:b215626183 . _:b215625847 "30"^^ . _:b215626052 . _:b215626182 . _:b215626891 . . _:b215626177 . _:b215625841 "37"^^ . _:b215626176 . _:b215626761 . _:b215626504 . _:b215625840 "38"^^ . _:b215626179 . _:b215625842 "33"^^ . . . . _:b215627293 . _:b215626178 . _:b215625843 "33"^^ . _:b215625862 . . _:b215625838 "40"^^ . . _:b215626189 . . . . _:b215625839 "40"^^ . _:b215626188 . _:b215626733 . _:b215625964 . _:b215626727 . _:b215626191 . _:b215626699 . _:b215625917 . _:b215626190 . _:b215625984 . _:b215627528 . _:b215626185 . . _:b215626184 . _:b215626187 . _:b215625919 . . _:b215626186 . _:b215626203 . _:b215626624 . _:b215626197 . _:b215625851 "29"^^ . . _:b215625837 "63"^^ . . _:b215626196 . _:b215625850 "29"^^ . _:b215625836 "70"^^ . _:b215627473 . _:b215626199 . . _:b215626156 . _:b215626198 . _:b215625855 "26"^^ . _:b215627144 . _:b215626193 . _:b215626351 . _:b215625854 "26"^^ . _:b215626306 . _:b215625835 "72"^^ . _:b215625834 "76"^^ . _:b215626192 . _:b215625853 "27"^^ . _:b215626195 . . _:b215625852 "28"^^ . _:b215626194 . _:b215626205 . _:b215626541 . . . _:b215625858 "26"^^ . _:b215626204 . _:b215625859 "25"^^ . _:b215625857 "26"^^ . _:b215626207 . _:b215626506 . _:b215625856 "26"^^ . _:b215626969 . _:b215626206 . _:b215625862 "23"^^ . _:b215626201 . _:b215625863 "23"^^ . _:b215626200 . . _:b215626040 . _:b215627667 . _:b215626203 . _:b215627660 . _:b215625860 "25"^^ . . _:b215625861 "23"^^ . _:b215626202 . _:b215625866 "22"^^ . _:b215626213 . _:b215626212 . _:b215625864 "22"^^ . . _:b215626655 . _:b215626215 . _:b215625867 "21"^^ . _:b215625865 "22"^^ . _:b215626214 . . . . _:b215626748 . _:b215626829 . _:b215627450 . _:b215626209 . _:b215625869 "21"^^ . . _:b215627010 . _:b215625868 "21"^^ . _:b215626208 . . _:b215625871 "21"^^ . _:b215626211 . _:b215625870 "21"^^ . _:b215626210 . . . _:b215626000 . _:b215625873 "20"^^ . _:b215626221 . _:b215625872 "20"^^ . _:b215626220 . _:b215625975 . _:b215625875 "20"^^ . _:b215626258 . _:b215626223 . _:b215626600 . . _:b215625874 "20"^^ . _:b215626222 . _:b215625877 "19"^^ . _:b215626217 . _:b215626404 . _:b215625876 "19"^^ . _:b215626216 . . _:b215625879 "19"^^ . . _:b215626915 . _:b215626219 . _:b215625878 "19"^^ . _:b215626440 . . _:b215626218 . _:b215625881 "18"^^ . . _:b215626229 . _:b215625880 "19"^^ . _:b215626562 . _:b215626660 . _:b215626228 . _:b215625883 "18"^^ . . _:b215626269 . _:b215627615 . _:b215626231 . _:b215625882 "18"^^ . . _:b215626230 . _:b215627339 . . _:b215625885 "18"^^ . _:b215626089 . . . _:b215626225 . _:b215626327 . _:b215625884 "18"^^ . . . _:b215626224 . _:b215626559 . . _:b116023 . _:b215625886 "17"^^ . _:b215626227 . _:b215627153 . . _:b215625887 "17"^^ . _:b215626226 . . _:b215626788 . _:b215625888 "17"^^ . . _:b215626237 . _:b215625889 "16"^^ . _:b215627447 . _:b215626008 . _:b215626236 . _:b215625890 "16"^^ . _:b215626239 . _:b215626616 . _:b215625891 "16"^^ . _:b215626238 . _:b215627501 . _:b215625892 "16"^^ . . _:b215626233 . . _:b215625893 "15"^^ . . _:b215626232 . _:b215625894 "15"^^ . . . _:b116031 . _:b215626235 . _:b215625895 "15"^^ . _:b215627429 . . _:b215626234 . . _:b215625896 "15"^^ . _:b215627181 . _:b215625897 "15"^^ . _:b215625898 "14"^^ . _:b215625899 "14"^^ . _:b215625970 . . _:b215625900 "14"^^ . _:b215626100 . . _:b215625901 "14"^^ . . _:b215625902 "14"^^ . _:b215627668 . _:b215625903 "14"^^ . . _:b215625904 "14"^^ . _:b215625911 "13"^^ . _:b215625905 "14"^^ . _:b215625910 "13"^^ . _:b215625906 "14"^^ . _:b215626958 . _:b215625909 "13"^^ . . _:b215625960 . _:b215626076 . . _:b215626455 . . _:b215625907 . _:b215625908 "13"^^ . _:b215626411 . . _:b215625907 "13"^^ . . _:b215627435 . _:b215626181 . _:b215627342 . _:b215626167 . _:b215627039 . _:b215625919 "12"^^ . . _:b215625918 "12"^^ . _:b215626968 . _:b215625917 "12"^^ . _:b215625933 . _:b215627737 . _:b215625916 "12"^^ . . _:b215625915 "12"^^ . _:b215626036 . _:b215625914 "12"^^ . _:b215625913 "12"^^ . _:b116030 "We and others have shown that the CD4+CD25+ population is solely responsible for inhibition of the induction of autoimmunity after 3dTx (>>13<<, 14). In addition, we have also demonstrated that the induction of CD25 expression on CD25\u2212 T cells derived from mice that express a transgenic TCR on a SCID background was not sufficient to suppress the induction of autoimmune disease" . _:b215625912 "12"^^ . _:b215626737 . _:b215625927 "11"^^ . . _:b215625926 "12"^^ . . . . _:b215626402 . . _:b215625925 "12"^^ . _:b215627580 . . . _:b215626961 . _:b215625924 "12"^^ . . _:b215627682 . . _:b215625923 "12"^^ . _:b215625922 "12"^^ . _:b215626145 . . _:b215626768 . _:b215625921 "12"^^ . _:b215625920 "12"^^ . _:b215626831 . _:b215625935 "11"^^ . _:b215625865 . . . . _:b215625934 "11"^^ . _:b215626120 . . . _:b215625933 "11"^^ . _:b215626297 . . _:b215626133 . _:b215625932 "11"^^ . _:b215626588 . _:b215625931 "11"^^ . . _:b215626353 . _:b215625930 "11"^^ . _:b215627646 . _:b215625929 "11"^^ . _:b215626847 . _:b215625928 "11"^^ . _:b215625943 "10"^^ . _:b215626869 . . _:b215625942 "11"^^ . . . _:b215626726 . . _:b215625941 "11"^^ . _:b215625993 . . _:b215625940 "11"^^ . . _:b215627586 . _:b215626139 . _:b215625939 "11"^^ . _:b215627581 . _:b215625938 "11"^^ . . . _:b215625937 "11"^^ . . . _:b116039 . . _:b215625936 "11"^^ . . _:b215625951 "10"^^ . . _:b215625950 "10"^^ . _:b215627407 . _:b215625949 "10"^^ . . _:b215627253 . _:b215626508 . _:b215625948 "10"^^ . _:b215627553 . _:b215626314 . _:b215625947 "10"^^ . . _:b215627151 . _:b215625946 "10"^^ . . _:b215625945 "10"^^ . _:b215626061 . _:b215626123 . _:b215625944 "10"^^ . . . _:b215625959 "10"^^ . . . _:b215625958 "10"^^ . _:b215625957 "10"^^ . . . . . _:b215627423 . _:b215625956 "10"^^ . _:b215625955 "10"^^ . _:b215625954 "10"^^ . _:b215626923 . _:b215625953 "10"^^ . . _:b215627569 . . _:b215625952 "10"^^ . . . . . _:b215625966 "9"^^ . . . . _:b215625996 . _:b215625967 "9"^^ . . _:b215625964 "10"^^ . _:b215627193 . _:b215625965 "9"^^ . _:b215625880 . _:b215625963 "10"^^ . . _:b215627692 . _:b215625962 "10"^^ . . _:b215626664 . _:b215625961 "10"^^ . . . _:b215625960 "10"^^ . . . _:b215625974 "9"^^ . _:b215626195 . _:b215625975 "9"^^ . . _:b215625972 "9"^^ . _:b215626407 . _:b215626491 . . _:b215626811 . _:b215625973 "9"^^ . _:b215625970 "9"^^ . _:b215627303 . _:b215625971 "9"^^ . _:b215626910 . _:b215625968 "9"^^ . _:b215627085 . _:b215625969 "9"^^ . . _:b215626157 . _:b215625982 "9"^^ . _:b215627304 . _:b215627522 . _:b215627539 . _:b215625983 "9"^^ . . _:b215626481 . _:b215626397 . . _:b215625980 "9"^^ . _:b215626645 . _:b215625981 "9"^^ . _:b215625978 "9"^^ . . _:b215625979 "9"^^ . _:b215626047 . _:b215625976 "9"^^ . _:b215626309 . _:b215625977 "9"^^ . _:b215626882 . _:b215625990 "8"^^ . _:b215625991 "8"^^ . _:b215627072 . _:b215626206 . . _:b215625988 "8"^^ . . _:b215625989 "8"^^ . _:b215627225 . _:b215626816 . . _:b215626304 . _:b215625986 "8"^^ . . _:b215626486 . _:b215625987 "8"^^ . _:b215626706 . . _:b215626088 . _:b215625984 "9"^^ . _:b215625985 "9"^^ . _:b215626015 . _:b215625998 "8"^^ . _:b215625999 "8"^^ . _:b215627600 . _:b215625996 "8"^^ . _:b215625997 "8"^^ . . . _:b215625994 "8"^^ . _:b215626678 . _:b215625995 "8"^^ . _:b215627230 . . _:b215625992 "8"^^ . _:b215626044 . _:b215626602 . _:b215625993 "8"^^ . _:b215627259 . _:b215626006 "8"^^ . _:b215625837 . _:b215626007 "8"^^ . _:b215625836 . . _:b215626004 "8"^^ . _:b116028 . _:b215626485 . _:b215625839 . _:b215625889 . _:b215625900 . _:b215626005 "8"^^ . _:b215625838 . . . _:b215626012 . . _:b215626002 "8"^^ . _:b116030 . . _:b215626013 . _:b215626003 "8"^^ . . _:b215626000 "8"^^ . _:b215625835 . _:b215626001 "8"^^ . _:b215625834 . . _:b215626014 "8"^^ . . _:b215625845 . _:b215626015 "8"^^ . _:b215625844 . _:b215627023 . _:b215626012 "8"^^ . _:b215626629 . _:b215625847 . _:b215627274 . . _:b215627633 . _:b215626013 "8"^^ . _:b215625846 . _:b215626010 "8"^^ . . _:b215625841 . . . _:b215626011 "8"^^ . . _:b215625840 . . _:b215627087 . _:b215626008 "8"^^ . . . _:b215625843 . _:b215626230 . . _:b215626009 "8"^^ . . _:b215625842 . _:b215626022 "8"^^ . _:b215625853 . . . . _:b215626023 "8"^^ . _:b215625852 . . _:b116022 . _:b215626020 "8"^^ . _:b116023 . _:b215625855 . . . _:b215626021 "8"^^ . . _:b215625854 . _:b215626332 . . _:b215626018 "8"^^ . . _:b215625849 . . _:b215627706 . . _:b215626019 "8"^^ . _:b215625848 . . _:b215626016 "8"^^ . _:b215625851 . _:b215626017 "8"^^ . _:b116028 . . _:b215625850 . _:b215626030 "7"^^ . _:b215627190 . _:b116029 . _:b215625861 . _:b215626328 . _:b215626031 "7"^^ . _:b116030 . _:b215625860 . _:b215627123 . _:b215627430 . _:b215626028 "8"^^ . _:b116031 . _:b215625863 . . _:b215626029 "7"^^ . _:b116024 . _:b215625862 . . . . _:b215626026 "8"^^ . _:b116025 . _:b215626778 . _:b215625857 . _:b215626027 "8"^^ . _:b116026 . _:b215625856 . _:b215626024 "8"^^ . _:b215625859 . _:b116027 . _:b215626025 "8"^^ . _:b116036 . _:b215625858 . _:b215626287 . _:b215626868 . _:b215626038 "7"^^ . _:b116037 . _:b215625869 . . _:b215626039 "7"^^ . _:b116038 . _:b215625868 . _:b215626036 "7"^^ . _:b215625923 . _:b116039 . _:b215625871 . _:b215627344 . _:b215626170 . _:b215626037 "7"^^ . . _:b215627500 . _:b116032 . _:b215625870 . _:b215626842 . _:b215626034 "7"^^ . _:b116033 . _:b215625865 . _:b215626035 "7"^^ . _:b215627434 . _:b215625864 . _:b116034 . . _:b215626032 "7"^^ . _:b215626594 . _:b116035 . _:b215625867 . _:b215626315 . _:b215626033 "7"^^ . _:b116044 . _:b215625866 . _:b215626046 "7"^^ . _:b116045 . _:b215625877 . _:b215626047 "7"^^ . _:b116046 . _:b215625876 . . _:b215626044 "7"^^ . . _:b116047 . _:b215625879 . _:b215626045 "7"^^ . . _:b116040 . _:b215625878 . . _:b215626906 . _:b215626042 "7"^^ . _:b116041 . . _:b215626319 . _:b215625873 . _:b215626043 "7"^^ . . _:b215626551 . _:b116042 . _:b215625872 . _:b215625908 . _:b215627370 . _:b215627724 . _:b215626040 "7"^^ . _:b116043 . _:b215625875 . _:b215626041 "7"^^ . _:b215627145 . _:b215625874 . _:b215626054 "7"^^ . . _:b215625885 . _:b215626055 "7"^^ . . . _:b215626246 . _:b215625884 . . . _:b215626052 "7"^^ . _:b215625887 . _:b215626584 . . _:b215626053 "7"^^ . _:b116048 . _:b215625886 . _:b215626050 "7"^^ . _:b215626219 . _:b116049 . _:b215625881 . _:b215626030 . _:b215626051 "7"^^ . _:b215627588 . _:b116050 . _:b215625880 . _:b215626048 "7"^^ . _:b116051 . _:b215625883 . _:b215627352 . . _:b215626049 "7"^^ . . _:b215625882 . _:b215626062 "7"^^ . . _:b215625893 . _:b215626063 "7"^^ . _:b215625892 . _:b215626060 "7"^^ . . _:b215625895 . _:b215626178 . _:b215627160 . _:b215626061 "7"^^ . _:b215625894 . _:b215626272 . . _:b215626058 "7"^^ . _:b215625889 . _:b215626059 "7"^^ . _:b215625888 . . _:b215626056 "7"^^ . _:b215627106 . _:b215625891 . _:b215626057 "7"^^ . _:b116037 "it still remains possible that TGF-\u03B2 may play some role in the action of these cells in vivo, as TGF-\u03B2\u2212/\u2212 mice develop spontaneous inflammatory disease of a variety of organs and have an increase in Th1 inflammatory cytokines (>>23<<). The potential relationship of the CD4+CD25+ population to the CD45RBlow cells whose ability to protect animals from inflammatory bowel disease could be reversed by anti\u2013TGF-\u03B2 (24) and with TGF-\u03B2\u2013producing suppressor populations (the" . . _:b215626752 . _:b215625890 . _:b215626070 "6"^^ . _:b215625901 . _:b215627657 . . _:b215626071 "6"^^ . . _:b215626548 . _:b215625900 . _:b215626068 "6"^^ . _:b215625903 . _:b215626069 "6"^^ . . . _:b215625902 . _:b215626066 "7"^^ . _:b215625897 . _:b215627044 . _:b215626067 "7"^^ . . _:b215625896 . _:b215626064 "7"^^ . . _:b215627593 . _:b215625899 . . _:b215626065 "7"^^ . _:b215627312 . _:b215625898 . _:b215626515 . _:b215626078 "6"^^ . . _:b215626085 . _:b215625909 . _:b215626079 "6"^^ . _:b215625908 . _:b215626076 "6"^^ . . . _:b215625911 . _:b215626723 . _:b215626077 "6"^^ . . . . _:b215625910 . _:b215626074 "6"^^ . . . . _:b215625905 . _:b215626075 "6"^^ . . . _:b215625904 . _:b215626072 "6"^^ . _:b116032 . _:b215625907 . . _:b215626073 "6"^^ . _:b215626046 . _:b215627350 . . _:b215625906 . _:b215626086 "6"^^ . . _:b215625917 . . _:b215626087 "6"^^ . _:b215626270 . _:b215625916 . _:b215626084 "6"^^ . _:b215627718 . _:b215625919 . _:b215626085 "6"^^ . _:b215627475 . _:b215625918 . _:b215626082 "6"^^ . _:b215626417 . . . . _:b215625913 . _:b215626083 "6"^^ . _:b215627607 . _:b215625912 . _:b215626080 "6"^^ . _:b215627729 . _:b215625915 . _:b215626081 "6"^^ . _:b215625914 . _:b215627655 . _:b215626094 "6"^^ . . _:b116051 . _:b215625925 . . _:b215626095 "6"^^ . _:b215626789 . _:b215627163 . _:b215625924 . _:b215626092 "6"^^ . . _:b215625927 . _:b215626525 . _:b215626093 "6"^^ . . _:b215625926 . _:b215626090 "6"^^ . _:b215627117 . _:b215625921 . _:b215626618 . . _:b215626091 "6"^^ . . _:b215626740 . _:b116051 "Cobbold et al. (>>40<<) have also proposed that the suppressor populations induced by nondepleting anti-CD4 mAbs in a model of infectious transplantation tolerance are alloantigen-specific cells that are incapable of differentiating into effectors, but function" . . _:b215625920 . _:b215626088 "6"^^ . _:b215625923 . . . _:b215626089 "6"^^ . . _:b215625922 . _:b215626102 "6"^^ . _:b215626527 . _:b215625933 . . _:b215626103 "6"^^ . . _:b215625932 . _:b215626100 "6"^^ . _:b215626461 . _:b215625935 . _:b215626101 "6"^^ . _:b215626638 . _:b215626636 . _:b215625934 . _:b215626098 "6"^^ . _:b215625929 . _:b215626939 . _:b215626099 "6"^^ . _:b215627082 . . _:b215626806 . _:b215625928 . . _:b215626096 "6"^^ . _:b215626533 . . _:b215625931 . _:b215626097 "6"^^ . _:b215626522 . _:b215625930 . _:b116045 . _:b215626110 "6"^^ . . _:b215625941 . . _:b215626111 "6"^^ . _:b215625940 . . _:b215627735 . _:b215626571 . . _:b215626108 "6"^^ . _:b215626840 . _:b215625943 . _:b215626109 "6"^^ . . _:b215625942 . _:b215627449 . . _:b215626106 "6"^^ . . _:b215625937 . _:b215627673 . _:b215626107 "6"^^ . _:b215625936 . _:b215626945 . _:b215626104 "6"^^ . _:b215625939 . _:b215626105 "6"^^ . . _:b215625938 . _:b215626118 "6"^^ . . _:b215625949 . _:b215626119 "6"^^ . _:b215626666 . . . _:b215625948 . _:b215626116 "6"^^ . _:b215627166 . _:b215625951 . _:b215626117 "6"^^ . . . _:b215625950 . _:b215626114 "6"^^ . _:b215626722 . . _:b215625945 . _:b215626115 "6"^^ . _:b215625944 . _:b215626112 "6"^^ . . _:b215626462 . _:b215625947 . _:b215626296 . _:b215626113 "6"^^ . _:b215625946 . _:b215626126 "6"^^ . . _:b215625957 . _:b215626127 "6"^^ . . _:b215625956 . _:b215627518 . _:b215626769 . _:b215626124 "6"^^ . _:b215627481 . . _:b215625959 . _:b215626125 "6"^^ . _:b215626140 . _:b215627654 . _:b215626162 . _:b215625958 . _:b215626122 "6"^^ . _:b215625953 . . _:b215626123 "6"^^ . _:b215625952 . . _:b215626120 "6"^^ . _:b215626895 . _:b215625955 . _:b215626121 "6"^^ . _:b215625954 . _:b215625965 . . _:b215627346 . _:b215626988 . _:b215625964 . _:b215626132 "6"^^ . _:b215626887 . _:b215626135 "5"^^ . _:b215625967 . _:b215626133 "6"^^ . . . _:b215626134 "5"^^ . _:b215627621 . _:b215627199 . _:b215625966 . _:b215626130 "6"^^ . _:b215625936 . _:b215625961 . _:b215626131 "6"^^ . _:b215625947 . _:b215625960 . _:b215627278 . _:b215626128 "6"^^ . _:b215627598 . _:b215627495 . _:b215626863 . _:b215625963 . _:b215626129 "6"^^ . _:b215627554 . _:b215625962 . . _:b215626141 "5"^^ . _:b215627387 . _:b215625973 . . _:b215626140 "5"^^ . _:b215625972 . _:b215626143 "5"^^ . _:b215625975 . _:b215626142 "5"^^ . _:b215625974 . _:b215626137 "5"^^ . _:b215625969 . _:b215626136 "5"^^ . . _:b215625968 . . _:b215626139 "5"^^ . _:b215627708 . _:b215625971 . _:b215626482 . _:b215626138 "5"^^ . _:b215625970 . _:b215626105 . . _:b215626149 "5"^^ . _:b215625981 . _:b215625959 . . _:b215626148 "5"^^ . . _:b215625980 . . _:b215626418 . . _:b215626151 "5"^^ . _:b215625983 . . _:b215626150 "5"^^ . _:b215625982 . _:b215626145 "5"^^ . _:b215625977 . . _:b215626144 "5"^^ . _:b215625976 . _:b215626971 . _:b215626322 . _:b215626144 . . _:b215626147 "5"^^ . _:b215625979 . _:b215626146 "5"^^ . . _:b215625978 . _:b215627394 . _:b215626157 "5"^^ . _:b215626950 . . . _:b215627498 . _:b215626493 . _:b215626156 "5"^^ . _:b215626159 "5"^^ . . . _:b215627511 . _:b215626158 "5"^^ . _:b215625950 . . _:b215626153 "5"^^ . . _:b215626152 "5"^^ . . . _:b215626708 . _:b215627093 . _:b215626155 "5"^^ . _:b215626872 . _:b215626154 "5"^^ . . _:b215627131 . . _:b215626165 "5"^^ . _:b215627637 . . . _:b215626164 "5"^^ . _:b215626167 "5"^^ . _:b215627559 . _:b215626166 "5"^^ . . _:b215626161 "5"^^ . . _:b215626564 . _:b215626159 . . _:b215626160 "5"^^ . . . _:b215626436 . _:b215626936 . _:b215626163 "5"^^ . . . _:b215626162 "5"^^ . _:b215627354 . . _:b215627086 . _:b215626451 . _:b215627360 . _:b215626173 "5"^^ . . _:b215626164 . _:b215626172 "5"^^ . . _:b215627531 . . _:b215626175 "5"^^ . _:b215626225 . _:b215626174 "5"^^ . . _:b215627022 . _:b215627300 . _:b215626169 "5"^^ . _:b215625981 . _:b215625979 . . . _:b215626168 "5"^^ . . _:b215627116 . _:b215626171 "5"^^ . . _:b215626801 . _:b215626170 "5"^^ . . _:b215626181 "5"^^ . . _:b215626180 "5"^^ . . . . _:b215626183 "5"^^ . _:b215626889 . _:b215626182 "5"^^ . _:b215625899 . _:b215626172 . _:b215626177 "5"^^ . . . _:b215626176 "5"^^ . . _:b215626179 "5"^^ . _:b215627471 . . _:b215626178 "5"^^ . _:b215627440 . . _:b215626972 . . _:b215627564 . . . _:b215626189 "5"^^ . . . _:b215626188 "5"^^ . . . . _:b215625914 . _:b215626191 "5"^^ . _:b215626805 . _:b215626190 "5"^^ . . . _:b215626185 "5"^^ . _:b215627111 . _:b215626184 "5"^^ . _:b215626187 "5"^^ . _:b215626186 "5"^^ . . _:b215626197 "5"^^ . . _:b215626196 "5"^^ . _:b215626199 "5"^^ . . _:b215626198 "5"^^ . _:b215627178 . . . _:b215626193 "5"^^ . _:b215626192 "5"^^ . . _:b215626195 "5"^^ . _:b215626194 "5"^^ . _:b215626205 "5"^^ . . _:b215626204 "5"^^ . _:b215626853 . _:b215626207 "5"^^ . _:b215627291 . _:b215627096 . . _:b215627629 . _:b215626867 . _:b215626441 . _:b215626206 "5"^^ . . _:b215626201 "5"^^ . . _:b215626200 "5"^^ . _:b215627161 . _:b215626203 "5"^^ . _:b215627612 . . . _:b215626202 "5"^^ . . _:b215627399 . _:b215626213 "5"^^ . . _:b215626212 "5"^^ . _:b215626215 "5"^^ . _:b215626377 . _:b215626214 "5"^^ . _:b116040 "the CD45RBlow cells whose ability to protect animals from inflammatory bowel disease could be reversed by anti\u2013TGF-\u03B2 (24) and with TGF-\u03B2\u2013producing suppressor populations (the so-called Th3 cells) induced by oral delivery of antigen (25, >>26<<) remains to be determined." . _:b215625892 . _:b215627472 . _:b215627689 . _:b215626209 "5"^^ . _:b215626065 . _:b215626208 "5"^^ . . _:b215627507 . . _:b215626211 "5"^^ . _:b215627742 . . _:b215626210 "5"^^ . . . _:b215627235 . . _:b215626221 "5"^^ . _:b215626220 "5"^^ . _:b215626667 . . _:b215626223 "5"^^ . _:b215627494 . _:b215626318 . . . _:b215626222 "5"^^ . _:b215626904 . _:b215626217 "5"^^ . _:b215626081 . _:b215625946 . _:b215626216 "5"^^ . . _:b215627516 . _:b215626219 "5"^^ . . _:b215626218 "5"^^ . _:b215626229 "5"^^ . . . _:b215626228 "5"^^ . _:b215627679 . _:b215626231 "5"^^ . . _:b215626230 "5"^^ . . _:b215626225 "5"^^ . _:b215627582 . _:b215627663 . _:b215626224 "5"^^ . . _:b215626672 . _:b215626227 "5"^^ . . _:b215626919 . _:b215626226 "5"^^ . _:b215626053 . _:b215626237 "5"^^ . _:b215626236 "5"^^ . _:b215626239 "5"^^ . _:b215625871 . _:b215626238 "5"^^ . _:b215625870 . . _:b215626233 "5"^^ . . _:b215626147 . _:b215626232 "5"^^ . _:b215626235 "5"^^ . . _:b215626858 . _:b215626427 . _:b215626360 . . . _:b215626234 "5"^^ . . _:b215627308 . . . . _:b215626231 . . _:b215627263 . _:b215625867 . _:b215626292 . _:b215625920 . _:b215626082 . _:b215626813 . _:b215626129 . _:b215625864 . . . . _:b215625857 . _:b215626637 . . _:b215627218 . . . . _:b215626681 . _:b116042 . _:b215626510 . . _:b215626301 . _:b215627385 . . _:b215626641 . . . _:b215625877 . _:b215627057 . . . . . . _:b215626340 . . _:b215627672 . _:b215626550 . _:b215627321 . _:b215627620 . . . _:b215626786 . _:b215626839 . _:b215625881 . . . . _:b215626604 . . _:b215627266 . _:b215627247 . . _:b215626720 . . _:b215626494 . _:b215627336 . _:b215626380 . . . . _:b215627426 . . _:b215626303 . _:b215626560 . . _:b215627236 . . _:b215626357 . _:b215626083 . . . _:b215626514 . _:b215626079 . . . . _:b215627595 . . _:b215626062 . _:b215627437 . . . _:b215627695 . _:b215627645 . _:b215627026 . _:b215626211 . _:b215626899 . . _:b215627109 . _:b215627254 . _:b215626596 . . _:b215626955 . _:b215627334 . . _:b215627465 . _:b215626299 . . _:b215626709 . _:b215626943 . . . _:b215626963 . _:b215626640 . _:b215626617 . . _:b116036 . _:b215626242 . . _:b215626425 . _:b215626175 . _:b215627032 . _:b116047 . _:b215627265 . _:b215626099 . _:b215626224 . . . . . _:b215627699 . . . . . . _:b215627279 . . . _:b215627165 . _:b215626995 . _:b215627535 . _:b215627594 . _:b215626437 . _:b215626642 . _:b215626201 . . . _:b215627226 . . _:b215626465 . _:b215627129 . _:b215626488 . . _:b215626521 . _:b215627083 . . . . _:b215626018 . _:b215626663 . . . . _:b116049 . _:b215627003 . _:b215625854 . . _:b215625904 . _:b215627119 . _:b215627333 . . _:b215626615 . . _:b215626587 . _:b215626742 . _:b215627177 . _:b215626866 . _:b215625999 . . . _:b215626071 . . _:b116024 "Noben-Trauth (NIAID, National Institutes of Health) (>>17<<) and were bred in our facilities." . _:b215627126 . . _:b215626901 . . . _:b215626941 . _:b215627669 . _:b215626212 . _:b215627376 . _:b215627551 . . . . . . _:b215627284 . _:b215626124 . . _:b215626063 . _:b116025 "BALB/c mice were thymectomized on day 3 of life and screened for the presence of antigastric autoantibodies as previously described (>>18<<)." . _:b215627466 . _:b215626620 . . . . . _:b215627622 . . . _:b215627054 . . _:b215626116 . _:b215627055 . _:b215625992 . . . _:b215626558 . . . _:b215626998 . . _:b215627220 . . _:b215626204 . . . . _:b215626926 . . _:b215627412 . _:b215627073 . _:b215627565 . _:b215626428 . . _:b116031 "We and others have shown that the CD4+CD25+ population is solely responsible for inhibition of the induction of autoimmunity after 3dTx (13, >>14<<). In addition, we have also demonstrated that the induction of CD25 expression on CD25\u2212 T cells derived from mice that express a transgenic TCR on a SCID background was not sufficient to suppress the induction of autoimmune disease after" . . _:b215626643 . . . _:b215626161 . _:b215626526 . _:b215626848 . . . _:b215626903 . _:b215627100 . _:b215626316 . _:b215626045 . . _:b215627572 . _:b215627652 . _:b215627115 . _:b215627288 . _:b215626244 . _:b215627088 . . . . . _:b215625973 . . . _:b215626038 . . . _:b215627541 . . _:b215627726 . . _:b215625986 . . . _:b215627599 . . . _:b215626516 . . . . . . . . . _:b215626041 . . _:b215627509 . . . . . . _:b215626935 . . _:b215627335 . _:b215626409 . . _:b215626851 . _:b215627386 . _:b215626177 . _:b215626057 . _:b215626892 . _:b116039 "to the CD45RBlow cells whose ability to protect animals from inflammatory bowel disease could be reversed by anti\u2013TGF-\u03B2 (24) and with TGF-\u03B2\u2013producing suppressor populations (the so-called Th3 cells) induced by oral delivery of antigen (>>25<<, 26) remains to be determined." . . _:b215627053 . . . . _:b215627736 . . . _:b215627712 . . _:b215627192 . _:b215627367 . _:b215626114 . . . . _:b215626601 . _:b215627719 . _:b215626830 . _:b215627097 . _:b215627650 . _:b215626345 . _:b215626149 . _:b116036 "Neutralizing antisuppressor cytokine mAbs alone or in combination also failed to abrogate suppression. Finally, to rule out the involvement of the newly described (>>22<<) T regulatory 1 population that exerts bystander suppression by the secretion of IL-10, we demonstrated that CD4+CD25+ cells from both IL-4\u2212/\u2212 and IL-10\u2212/\u2212 donors were as effective as T cells from wild-type mice in mediating suppression" . _:b215626784 . _:b215626747 . . . _:b215626682 . _:b215627397 . . . _:b215627046 . . _:b215627041 . . . _:b215626701 . . _:b215627590 . _:b215626854 . _:b215627372 . _:b215626039 . . . _:b215626948 . _:b215627693 . . _:b116028 "These results are in contrast to the results of Asano et al. (>>13<<), in which unstimulated CD4+CD25+ cells expressed IL-2, IL-4, and TGF-\u03B2, as well as IL-10." . _:b215627327 . _:b215626821 . . . _:b215625935 . . . . . . _:b215627130 . . _:b215627519 . . . . . . . . _:b215627052 . _:b215626389 . . . _:b215627608 . . _:b215627561 . _:b215625897 . . . . _:b215626738 . . . . . _:b215626911 . . _:b116023 "11.10-TCR transgenic SCID mice were bred in our own facilities (>>14<<). IL-4\u2212/\u2212 mice (BALB/c background) were originally obtained from N." . . _:b215626121 . _:b215627540 . _:b215627604 . _:b215627150 . . _:b215626075 . . . _:b215627090 . _:b215626894 . _:b215627213 . _:b215627120 . . . . _:b215627140 . . . . _:b215627318 . . _:b215626300 . _:b215627323 . _:b215626281 . _:b116034 "discussion" . . _:b215626483 . _:b215625878 . _:b215626797 . . _:b215626049 . . . _:b215627493 . _:b215625868 . _:b215627311 . _:b215627639 . _:b215626547 . _:b215627408 . _:b215626361 . _:b215626700 . _:b215627157 . . _:b215627596 . _:b215626980 . . _:b215627301 . _:b215626405 . . . . . . . . _:b215627661 . _:b215627503 . _:b215627094 . . _:b215625949 . . . _:b215626743 . _:b215627508 . . _:b215627313 . . . _:b215626658 . . _:b215627280 . _:b215626247 . . . _:b215626865 . _:b215626412 . . _:b215626569 . _:b215627343 . _:b215626150 . . _:b215627677 . . _:b215626612 . . _:b215625869 . . . _:b215627048 . _:b215626371 . . . _:b215626490 . _:b215626401 . . . . _:b215626883 . _:b215626800 . . _:b215626608 . . _:b215626034 . . _:b215626593 . _:b215627305 . _:b215627491 . . _:b215626215 . _:b215626463 . _:b215626553 . . . . . _:b215627713 . . . _:b215627380 . _:b215626772 . . _:b116033 "Paradoxically, a greater percentage (25\u201330 versus 10%) of CD4+ T cells in 3dTx mice express CD25 compared with normal mice (>>18<<). To rule out the possibility that the in vivo induction of CD25 would render cells suppressive, CD4+CD25+ cells were purified from 3dTx mice between 4 and 6 mo of age and added to cultures of CD4+CD25\u2212 cells from normal BALB/c mice. No" . . . _:b215627676 . . . . . . . _:b215626528 . . . . . _:b215627573 . _:b215626339 . _:b215627214 . . _:b215626798 . . _:b215627198 . _:b215626020 . _:b215626064 . _:b215626343 . _:b215627703 . . _:b215627485 . . _:b215627295 . . _:b215627525 . _:b215627524 . . _:b215627527 . _:b215626524 . _:b215627526 . . . _:b215627521 . _:b215626387 . . _:b215627520 . _:b215626960 . _:b215627523 . _:b215627522 . _:b215626538 . . _:b215626774 . _:b215627533 . _:b215627532 . . . _:b215626393 . _:b215627535 . _:b215626291 . _:b215626450 . _:b215627534 . _:b215626182 . _:b215627025 . _:b215627529 . _:b215626445 . _:b215627610 . _:b215627476 . _:b215627528 . . _:b215627531 . _:b215627530 . . _:b215627659 . _:b215627541 . . _:b215626384 . . . _:b215627540 . _:b215627628 . _:b215627543 . . _:b215627194 . _:b215627246 . _:b215627542 . _:b215627436 . _:b215626426 . _:b215627137 . _:b215626165 . _:b215627537 . . _:b215627536 . _:b215627017 . _:b215627108 . _:b215627257 . _:b215627539 . _:b215627464 . _:b215627538 . _:b215627549 . . . _:b215626006 . _:b215627548 . . _:b215627551 . _:b215626138 . _:b215627550 . _:b116029 . _:b116033 . _:b215626207 . _:b215627545 . . . _:b215627544 . . . . _:b215627547 . _:b215627546 . . _:b215627557 . _:b215627681 . . _:b215627556 . _:b215626973 . . _:b215627559 . _:b215627558 . . _:b215627553 . _:b215626876 . _:b215627552 . . _:b215626232 . _:b215627555 . _:b215626054 . _:b215627445 . . _:b215627554 . . _:b215627565 . _:b215625925 . _:b215627564 . . _:b215626168 . _:b215627567 . . _:b215627566 . _:b215627561 . . _:b215626060 . . _:b215627560 . . _:b215627563 . . _:b215627562 . . . _:b215627573 . . _:b215627572 . . _:b215627560 . _:b215627575 . . . _:b215627574 . . _:b215626583 . _:b116025 . _:b215626364 . . . . _:b215627569 . _:b215627568 . . . _:b215627571 . _:b215627510 . _:b215625846 . . _:b215627570 . _:b215627581 . _:b215627330 . _:b116044 . _:b215627580 . _:b215626320 . . _:b215627583 . _:b215626070 . . _:b215627582 . _:b215626422 . _:b215627577 . _:b215625850 . . _:b215626033 . _:b215627576 . _:b215626609 . _:b215627579 . . . . . _:b215627578 . _:b215627201 . . _:b215627589 . _:b215626132 . . _:b215627588 . _:b215627544 . _:b215627591 . . _:b215627420 . _:b215627574 . _:b215627590 . _:b215627217 . _:b215627585 . . _:b215627584 . . _:b215626255 . _:b215627587 . _:b215626326 . _:b215627586 . _:b215626777 . _:b215627597 . . _:b215627596 . . . _:b215627599 . . _:b215627598 . _:b215627631 . _:b215626492 . _:b215626477 . _:b215627593 . _:b215626406 . _:b215627425 . . _:b215627592 . _:b215627149 . . _:b215627734 . _:b215627595 . _:b215626595 . . _:b215627594 . _:b215627605 . . . . _:b215627604 . _:b215627557 . _:b215627607 . . _:b215626454 . _:b215627606 . _:b215627125 . _:b215627601 . _:b215626358 . _:b215626321 . _:b215627600 . _:b215627603 . . _:b215627602 . _:b215627269 "2"^^ . _:b215626265 . _:b215626113 . _:b215627033 . _:b215626827 . _:b215627613 . _:b215627268 "2"^^ . _:b215627612 . _:b215627271 "2"^^ . . _:b215627543 . _:b215627615 . _:b215627270 "2"^^ . _:b215627362 . . _:b215627614 . . _:b215627265 "2"^^ . . _:b215625922 . _:b215627609 . _:b215627264 "2"^^ . _:b215627608 . _:b215627267 "2"^^ . _:b215627611 . _:b215627266 "2"^^ . _:b215626497 . . _:b215626143 . _:b215627610 . _:b215627277 "2"^^ . _:b215627621 . _:b215627276 "2"^^ . _:b215627620 . . _:b215627279 "2"^^ . . _:b215627623 . _:b215627278 "2"^^ . . _:b215627622 . _:b215627273 "2"^^ . . . _:b215627617 . . _:b215627272 "2"^^ . . _:b215627241 . _:b215627616 . _:b215627275 "2"^^ . _:b215626736 . _:b215627619 . _:b215627274 "2"^^ . _:b215627618 . _:b215627285 "2"^^ . _:b215627262 . _:b215627629 . _:b215627284 "2"^^ . _:b215627628 . _:b215627287 "2"^^ . _:b215627631 . _:b215627152 . _:b215627286 "2"^^ . . _:b215626859 . _:b215627630 . _:b215626802 . _:b215627281 "2"^^ . . _:b215627625 . _:b215626822 . _:b215627280 "2"^^ . _:b215627183 . _:b215626072 . _:b215627006 . _:b215625848 . _:b215627624 . _:b215626446 . _:b215627283 "2"^^ . . _:b215627627 . _:b215627282 "2"^^ . _:b215626179 . _:b215627626 . _:b215627293 "2"^^ . _:b215627637 . _:b215627292 "2"^^ . _:b215627636 . _:b215627295 "2"^^ . _:b215627146 . _:b215627639 . _:b215626741 . _:b215627294 "2"^^ . _:b215626849 . _:b215627638 . _:b215627289 "2"^^ . _:b215627633 . _:b215627288 "2"^^ . . _:b215626890 . . _:b215627632 . _:b215627291 "2"^^ . _:b215627635 . _:b215627290 "2"^^ . _:b215627634 . _:b215627301 "2"^^ . _:b215627645 . _:b215627300 "2"^^ . . . _:b215627644 . . _:b215627357 . _:b215627303 "2"^^ . _:b215626434 . . _:b215627647 . _:b215627302 "2"^^ . _:b215627646 . . _:b215627297 "2"^^ . _:b215625906 . _:b215627641 . _:b215627296 "2"^^ . _:b215627143 . _:b215627640 . . _:b215627299 "2"^^ . _:b215626592 . _:b215627643 . _:b215627298 "2"^^ . . _:b215627642 . _:b215626473 . _:b215627309 "2"^^ . _:b215627653 . _:b215627308 "2"^^ . _:b215627652 . _:b215627311 "2"^^ . _:b215627655 . _:b215627035 . _:b215627310 "2"^^ . _:b215627514 . _:b215627654 . . _:b215627305 "2"^^ . _:b215626280 . . _:b215627649 . _:b215627304 "2"^^ . _:b215627648 . _:b215627307 "2"^^ . _:b215627651 . _:b215627306 "2"^^ . _:b215627020 . _:b215627650 . _:b215627317 "2"^^ . . _:b215626763 . _:b215627661 . _:b215627316 "2"^^ . . _:b215627660 . _:b215627319 "2"^^ . _:b215627663 . . _:b215627318 "2"^^ . . _:b215626074 . _:b215627299 . _:b215626460 . _:b215627662 . _:b215627313 "2"^^ . _:b215626653 . _:b215627657 . _:b215627312 "2"^^ . _:b215627656 . _:b215627315 "2"^^ . _:b215625962 . _:b215627659 . _:b215626952 . _:b215627314 "2"^^ . _:b215627658 . . _:b215627325 "2"^^ . . _:b215627669 . . _:b215627324 "2"^^ . _:b215626240 . _:b215627668 . _:b215627327 "2"^^ . _:b215626226 . _:b215627671 . _:b215627326 "2"^^ . _:b215627725 . . _:b215625874 . _:b215627670 . _:b215627321 "2"^^ . . _:b215627665 . . _:b215627320 "2"^^ . . _:b215627664 . _:b215626042 . _:b215627323 "2"^^ . . . _:b215627667 . . _:b215627322 "2"^^ . . . . . _:b215626302 . _:b215627666 . . _:b215627333 "2"^^ . . _:b215627677 . . _:b215627332 "2"^^ . . _:b215627676 . _:b215627335 "2"^^ . . _:b215627679 . . _:b215627334 "2"^^ . _:b215626574 . _:b215627678 . _:b215627329 "2"^^ . _:b215626142 . _:b215627673 . _:b215625883 . _:b215627328 "2"^^ . _:b215626174 . _:b215626391 . _:b215627672 . _:b215627331 "2"^^ . . _:b215627675 . _:b215627330 "2"^^ . _:b215627027 . _:b116035 . _:b215627674 . _:b215627341 "2"^^ . . _:b215626025 . _:b215627685 . . _:b215627340 "2"^^ . _:b215627684 . _:b215627343 "2"^^ . _:b215627379 . _:b215627174 . _:b215627687 . _:b215627342 "2"^^ . _:b215627686 . _:b215627337 "2"^^ . . _:b215627681 . . _:b215627617 . _:b215627336 "2"^^ . _:b215625998 . _:b215626751 . _:b215627680 . _:b215627289 . _:b215627339 "2"^^ . . _:b215627683 . _:b215627338 "2"^^ . _:b215627682 . . _:b215627349 "2"^^ . . . _:b215627710 . _:b215627693 . _:b215627348 "2"^^ . _:b215627692 . _:b215627351 "2"^^ . _:b215627695 . _:b215627350 "2"^^ . . . _:b215627694 . _:b215627345 "2"^^ . _:b215627091 . _:b215627337 . . _:b215627689 . _:b215627344 "2"^^ . _:b215627409 . . _:b215627688 . _:b215626312 . _:b215627347 "2"^^ . _:b215627290 . _:b215627691 . _:b215625863 . _:b215627346 "2"^^ . . _:b215627690 . _:b215627357 "2"^^ . . . _:b215627701 . _:b215627356 "2"^^ . _:b215627700 . _:b215627359 "2"^^ . _:b215627703 . _:b215627358 "2"^^ . _:b215626874 . . _:b215627702 . _:b215627353 "2"^^ . _:b215627697 . _:b215627352 "2"^^ . . _:b215627696 . _:b215627355 "2"^^ . . _:b215627699 . _:b215627354 "2"^^ . _:b215627728 . _:b215627698 . _:b215627365 "2"^^ . _:b215627709 . . _:b215627643 . _:b215627364 "2"^^ . . _:b215627708 . . _:b215627367 "2"^^ . _:b215627711 . . _:b215627366 "2"^^ . . _:b215627710 . _:b215627361 "2"^^ . _:b215627705 . _:b215627360 "2"^^ . . _:b215627704 . _:b215626220 . _:b215627363 "2"^^ . _:b215626368 . . . _:b215627707 . . _:b215627362 "2"^^ . . _:b215627706 . _:b215627216 . . _:b215627373 "2"^^ . _:b215626346 . . . _:b215625926 . _:b215627717 . _:b215626342 . _:b215627372 "2"^^ . . _:b215627716 . _:b215627375 "2"^^ . _:b215627719 . _:b215627374 "2"^^ . . _:b215627718 . _:b215627369 "2"^^ . _:b215626348 . _:b215627713 . _:b215627368 "2"^^ . _:b215625982 . _:b215627712 . _:b215627371 "2"^^ . _:b215627715 . _:b215627370 "2"^^ . _:b215626344 . _:b215627714 . _:b215627381 "2"^^ . _:b215627725 . . _:b215627380 "2"^^ . _:b215627724 . _:b215627383 "2"^^ . _:b215626651 . _:b215627171 . _:b215627727 . _:b215626453 . _:b215627382 "2"^^ . _:b215627726 . _:b215627377 "2"^^ . . _:b215627721 . _:b215626884 . _:b215625924 . _:b215627376 "2"^^ . . . _:b215627720 . . _:b215627379 "2"^^ . _:b215627723 . _:b215627378 "2"^^ . _:b215627722 . _:b215627389 "2"^^ . _:b215625955 . . _:b215627733 . _:b215627388 "2"^^ . _:b215627732 . _:b215627391 "2"^^ . _:b215626024 . _:b215627735 . _:b215626213 . _:b215627390 "2"^^ . _:b215626126 . _:b215627734 . _:b215627385 "2"^^ . _:b215625921 . _:b215626921 . _:b215627729 . _:b215627384 "2"^^ . _:b215627395 . _:b215627728 . . _:b215627387 "2"^^ . _:b215627018 . . _:b215625842 . _:b215627731 . . _:b215627386 "2"^^ . _:b215625945 . _:b215626818 . . _:b215627730 . _:b215627060 . . _:b215627397 "2"^^ . _:b215627158 . . _:b215627741 . _:b215627396 "2"^^ . . _:b215627740 . _:b215627399 "2"^^ . . . _:b215627743 . _:b215627398 "2"^^ . _:b215627001 . _:b215627742 . _:b215627393 "2"^^ . . . _:b215627737 . _:b215625851 . _:b215627392 "2"^^ . . _:b215626719 . _:b215627736 . . _:b215627395 "2"^^ . _:b215625905 . _:b215627739 . _:b215627394 "2"^^ . . _:b215627738 . _:b215627405 "2"^^ . _:b215627749 . . _:b215627404 "2"^^ . . _:b215627748 . . _:b215627407 "2"^^ . _:b215626338 . _:b215626372 . _:b116048 "No studies have suggested that receptor-based immunoregulation (>>37<<, 38) is operative in these model systems." . _:b215626862 . _:b215627406 "2"^^ . _:b215625988 . _:b215627670 . _:b215627401 "2"^^ . _:b215626026 . _:b215627745 . . _:b215627400 "2"^^ . _:b215627744 . _:b215625916 . _:b215627403 "2"^^ . _:b215626414 . _:b215627747 . _:b215627402 "2"^^ . _:b215627746 . _:b215627413 "2"^^ . _:b215627442 . . _:b215627412 "2"^^ . . . _:b215627415 "2"^^ . _:b215627414 "2"^^ . _:b215627175 . _:b215626679 . _:b215627409 "2"^^ . _:b215627408 "2"^^ . _:b215626623 . _:b215627411 "2"^^ . . _:b215627410 "2"^^ . _:b215627421 "2"^^ . . _:b215627420 "2"^^ . _:b215627423 "2"^^ . . . . _:b215627422 "2"^^ . _:b215627110 . _:b215627417 "2"^^ . . . _:b215627416 "2"^^ . _:b215627419 "2"^^ . _:b215627223 . _:b215627418 "2"^^ . . _:b215625991 . _:b215627429 "2"^^ . _:b215627428 "2"^^ . _:b215626096 . _:b215627431 "2"^^ . . _:b215627563 . _:b215626579 . . _:b215627430 "2"^^ . . _:b116034 _:b116044 . _:b215627271 . _:b116034 _:b116045 . _:b215627425 "2"^^ . _:b116034 _:b116046 . _:b116034 _:b116047 . _:b116034 _:b116040 . _:b116034 _:b116041 . _:b215627424 "2"^^ . _:b116034 _:b116042 . _:b116034 _:b116043 . _:b116034 _:b116036 . _:b116034 _:b116037 . _:b215627427 "2"^^ . _:b116034 _:b116038 . _:b116041 "Inhibition of IL-2 gene transcription has also been observed with suppressor T cell populations isolated from animals that have been recently subjected to total lymphoid irradiation (TLI; reference >>27<<). No information is available on the phenotype of the suppressor cells in that model, but spleen cells from TLI-treated animals contain increased numbers of CD4\u2212CD8\u2212CD3low cells. Although the binding of IL-2 by the CD4+CD25+ cells" . _:b116034 _:b116039 . _:b215627426 "2"^^ . . _:b116034 _:b116035 . _:b215627437 "2"^^ . . _:b215627499 . _:b215627269 . _:b215627436 "2"^^ . _:b215627268 . _:b215626500 . _:b215627439 "2"^^ . . _:b116034 _:b116048 . _:b215627271 . _:b116034 _:b116049 . _:b215627438 "2"^^ . _:b116034 _:b116050 . _:b116034 _:b116051 . _:b215627270 . _:b215627433 "2"^^ . _:b215627265 . _:b215627432 "2"^^ . _:b215626693 . _:b215627264 . _:b215627435 "2"^^ . _:b215625856 . _:b215627267 . _:b215627434 "2"^^ . . . _:b215627266 . . _:b215627445 "2"^^ . _:b215627209 . _:b215627277 . _:b215627444 "2"^^ . . _:b215627276 . _:b215627447 "2"^^ . . _:b215627279 . _:b215627446 "2"^^ . . . _:b215627638 . _:b215627278 . _:b215627441 "2"^^ . . _:b215627273 . _:b215627440 "2"^^ . . _:b215627272 . _:b116038 . . _:b215627443 "2"^^ . _:b215627275 . _:b215626783 . _:b215627442 "2"^^ . _:b215627274 . _:b215627453 "2"^^ . _:b215627285 . _:b215627452 "2"^^ . _:b215627284 . _:b215627455 "2"^^ . . . _:b215627707 . _:b215627287 . _:b215627454 "2"^^ . . _:b215627286 . _:b215627449 "2"^^ . _:b215626146 . _:b215627281 . . . _:b116022 _:b116024 . _:b116022 _:b116025 . _:b215627448 "2"^^ . _:b116022 _:b116026 . . _:b215627280 . . _:b215627451 "2"^^ . _:b116022 _:b116023 . _:b215627283 . . _:b215627450 "2"^^ . _:b215627205 . _:b215627282 . _:b215627461 "2"^^ . _:b215627293 . _:b215627460 "2"^^ . _:b116045 "Several studies (33, >>34<<) have presented evidence that the CD4+CD25+ population in the 3dTx model recognizes the same set of autoantigens as the autoantigen-specific effector pool, but these findings have not been confirmed (35)." . _:b215627524 . _:b215627292 . _:b215627463 "2"^^ . . _:b215627295 . . _:b215627462 "2"^^ . _:b215626690 . _:b215627045 . _:b215627294 . _:b215627457 "2"^^ . _:b215627289 . _:b215627456 "2"^^ . _:b215626962 . _:b215627288 . . _:b215627459 "2"^^ . _:b215626634 . _:b215626843 . _:b215627291 . _:b215627458 "2"^^ . . _:b215627290 . _:b215627469 "2"^^ . _:b215626912 . _:b116027 _:b116028 . _:b215627301 . _:b116027 _:b116029 . _:b215627468 "2"^^ . _:b116027 _:b116030 . _:b116027 _:b116031 . _:b215627300 . _:b215627471 "2"^^ . . _:b215627092 . _:b215627303 . . _:b215627093 . _:b215627470 "2"^^ . _:b215627094 . _:b215627095 . . _:b215627088 . _:b215627302 . _:b215627089 . _:b215627465 "2"^^ . _:b215627090 . _:b215627091 . _:b215627100 . _:b215627297 . _:b215627101 . _:b215627464 "2"^^ . _:b215627102 . _:b215627314 . _:b215627103 . _:b116027 _:b116032 . _:b215627296 . _:b215627096 . _:b116027 _:b116033 . _:b215627467 "2"^^ . _:b215627097 . _:b215627098 . _:b215627099 . _:b215627076 . _:b215627299 . _:b215627077 . _:b215627466 "2"^^ . _:b215626495 . _:b215627078 . _:b215626430 . _:b215627079 . _:b215627072 . _:b215627298 . _:b215627073 . _:b215627487 . _:b215627477 "2"^^ . _:b215627074 . . . _:b215627075 . _:b215627084 . _:b215627309 . . _:b215627085 . _:b215627476 "2"^^ . _:b215627086 . _:b215627087 . _:b215627080 . _:b215627308 . . _:b215627081 . _:b215627479 "2"^^ . _:b215627082 . _:b215627083 . _:b215627124 . _:b215627311 . . . _:b215627478 "2"^^ . _:b215626078 . _:b215627125 . . _:b215627126 . _:b215627127 . . _:b215627120 . _:b215627310 . . _:b215627121 . _:b215627473 "2"^^ . _:b215627122 . _:b215627123 . _:b215627132 . _:b215627305 . _:b215626379 . _:b215627472 "2"^^ . _:b215627133 . _:b215627134 . _:b215627135 . _:b215627128 . _:b215627525 . _:b215627304 . _:b215627129 . _:b215627475 "2"^^ . _:b215627317 . _:b215627130 . _:b215627131 . _:b215627108 . _:b215627307 . _:b215627109 . _:b215627474 "2"^^ . _:b215627110 . _:b215627111 . _:b215627730 . _:b215627104 . _:b215627306 . _:b215627105 . _:b215627485 "2"^^ . _:b215627106 . . _:b215627107 . _:b215627116 . _:b215627317 . _:b215627117 . _:b215627484 "2"^^ . . _:b215627118 . _:b215627119 . _:b215626597 . _:b215627112 . _:b215627316 . . _:b215627487 "2"^^ . _:b215627113 . . _:b215627537 . . _:b215627114 . _:b215627115 . _:b215627028 . _:b215627319 . _:b215626785 .