@prefix rdf: . @prefix ns1: . rdf:type ns1:RelevantPaper , ns1:ReferencePaper , ns1:CitationPaper . @prefix rdfs: . rdfs:seeAlso , , , . @prefix bibo: . bibo:cites , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ; ns1:cocitationWith , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ; ns1:hasRelevantBibliographicResourceOf _:b388051567 , _:b388051568 , _:b388051569 , _:b388051570 , _:b388051571 , _:b388051572 , _:b388051573 , _:b388051574 , _:b388051575 , _:b388051576 , _:b388051577 , _:b388051578 , _:b388051579 , _:b388051580 , _:b388051581 , _:b388051582 , _:b388051583 , _:b388051616 , _:b388051617 , _:b388051618 , _:b388051619 , _:b388051620 , _:b388051621 , _:b388051622 , _:b388051623 , _:b388051624 , _:b388051625 , _:b388051626 , _:b388051627 , _:b388051628 , _:b388051629 , _:b388051630 , _:b388051631 , _:b388051632 , _:b388051633 , _:b388051634 , _:b388051635 , _:b388051636 , _:b388051637 , _:b388051638 , _:b388051639 , _:b388051640 , _:b388051641 , _:b388051642 , _:b388051643 , _:b388051644 , _:b388051645 , _:b388051646 , _:b388051647 , _:b388051584 , _:b388051585 , _:b388051586 , _:b388051587 , _:b388051588 , _:b388051589 , _:b388051590 , _:b388051591 , _:b388051592 , _:b388051593 , _:b388051594 , _:b388051595 , _:b388051596 , _:b388051597 , _:b388051598 , _:b388051599 , _:b388051600 , _:b388051601 , _:b388051602 , _:b388051603 , _:b388051604 , _:b388051605 , _:b388051606 , _:b388051607 , _:b388051608 , _:b388051609 , _:b388051610 , _:b388051611 , _:b388051612 , _:b388051613 , _:b388051614 , _:b388051615 , _:b388051680 , _:b388051681 , _:b388051682 , _:b388051683 , _:b388051684 , _:b388051685 , _:b388051686 , _:b388051687 , _:b388051688 , _:b388051689 , _:b388051690 , _:b388051691 , _:b388051692 , _:b388051693 , _:b388051694 , _:b388051695 , _:b388051696 , _:b388051697 , _:b388051698 , _:b388051699 , _:b388051700 , _:b388051701 , _:b388051702 , _:b388051703 , _:b388051704 , _:b388051705 , _:b388051706 , _:b388051707 , _:b388051708 , _:b388051709 , _:b388051710 , _:b388051648 , _:b388051649 , _:b388051650 , _:b388051651 , _:b388051652 , _:b388051653 , _:b388051654 , _:b388051655 , _:b388051656 , _:b388051657 , _:b388051658 , _:b388051659 , _:b388051660 , _:b388051661 , _:b388051662 , _:b388051663 , _:b388051664 , _:b388051665 , _:b388051666 , _:b388051667 , _:b388051668 , _:b388051669 , _:b388051670 , _:b388051671 , _:b388051672 , _:b388051673 , _:b388051674 , _:b388051675 , _:b388051676 , _:b388051677 , _:b388051678 , _:b388051679 ; ns1:pmcid "PMC0" ; bibo:doi "10.1051%2Fvetres%3A2008043" . @prefix ns4: . ns4:contains _:b4178691 , _:b4178684 , _:b4178666 . _:b4178666 rdf:type ns4:Section . @prefix dc: . _:b4178666 dc:title "introduction" ; ns4:contains _:b4178668 , _:b4178669 , _:b4178670 , _:b4178671 , _:b4178667 , _:b4178680 , _:b4178681 , _:b4178682 , _:b4178683 , _:b4178676 , _:b4178677 , _:b4178678 , _:b4178679 , _:b4178672 , _:b4178673 , _:b4178674 , _:b4178675 . _:b4178667 rdf:type ns1:Context ; rdf:value "In the pig, few studies have been carried out in the last few years [>>32<<, 39, 41\u201344]." ; ns1:mentions . _:b4178668 rdf:type ns1:Context ; rdf:value "In the pig, few studies have been carried out in the last few years [32, >>39<<, 41\u201344]. Among these studies, some [39, 42] used the original approach of the small intestinal segment perfusion (SISP) [30]. This model was originally described to study the metabolite effects on intestine water absorption capacity [30]," ; ns1:mentions . _:b4178669 rdf:type ns1:Context ; rdf:value "In the pig, few studies have been carried out in the last few years [32, 39, >>41<<\u201344]. Among these studies, some [39, 42] used the original approach of the small intestinal segment perfusion (SISP) [30]. This model was originally described to study the metabolite effects on intestine water absorption capacity [30], but" ; ns1:mentions , , , . _:b4178670 rdf:type ns1:Context ; rdf:value "Among these studies, some [>>39<<, 42] used the original approach of the small intestinal segment perfusion (SISP) [30]." ; ns1:mentions . _:b4178671 rdf:type ns1:Context ; rdf:value "Among these studies, some [39, >>42<<] used the original approach of the small intestinal segment perfusion (SISP) [30]." ; ns1:mentions . _:b4178672 rdf:type ns1:Context ; rdf:value "Among these studies, some [39, 42] used the original approach of the small intestinal segment perfusion (SISP) [>>30<<]. This model was originally described to study the metabolite effects on intestine water absorption capacity [30], but has also proven to be a valuable technique to carry out genomic studies [39]. Markedly different host transcriptional" ; ns1:mentions . _:b4178673 rdf:type ns1:Context ; rdf:value "This model was originally described to study the metabolite effects on intestine water absorption capacity [>>30<<], but has also proven to be a valuable technique to carry out genomic studies [39]." ; ns1:mentions . _:b4178674 rdf:type ns1:Context ; rdf:value "This model was originally described to study the metabolite effects on intestine water absorption capacity [30], but has also proven to be a valuable technique to carry out genomic studies [>>39<<]. Markedly different host transcriptional profiles between Salmonella serovars Cholerasuis (narrow host range) and Typhimurium (broad host range) have been revealed [39]. Serovar Typhimurium-infected swine presented a transient induction" ; ns1:mentions . _:b4178675 rdf:type ns1:Context ; rdf:value "Markedly different host transcriptional profiles between Salmonella serovars Cholerasuis (narrow host range) and Typhimurium (broad host range) have been revealed [>>39<<]. Serovar Typhimurium-infected swine presented a transient induction of genes involved in innate and T-helper type-1 (Th1) response early in the infection (24\u201348\u2009h) followed by a significant repression of Interleukin 12 p35 (IL12 p35)," ; ns1:mentions . _:b4178676 rdf:type ns1:Context ; rdf:value "in innate and T-helper type-1 (Th1) response early in the infection (24\u201348\u2009h) followed by a significant repression of Interleukin 12 p35 (IL12 p35), IL12 p40, IL4, IL8 and Granulocyte/Macrophage Colony-Stimulating Factor (GM-CSF) [>>39<<]. The observed up-regulation of serum IFN gamma and TNF alpha supported the involvement of Th1-mediating cytokines in the porcine response to Salmonella infection." ; ns1:mentions . _:b4178677 rdf:type ns1:Context ; rdf:value "The clearance of intracellular pathogens such as Salmonella by the host is primarily accomplished by the activation of Th1-mediated immune responses [>>7<<, 11, 21, 45]." ; ns1:mentions . _:b4178678 rdf:type ns1:Context ; rdf:value "The clearance of intracellular pathogens such as Salmonella by the host is primarily accomplished by the activation of Th1-mediated immune responses [7, >>11<<, 21, 45]. More recently, a few studies [41\u201343] have been interested in porcine antimicrobial peptides in the context of Salmonella infection. An antimicrobial activity has been demonstrated for porcine beta-defensin 2 (PBD-2) against" ; ns1:mentions . _:b4178679 rdf:type ns1:Context ; rdf:value "The clearance of intracellular pathogens such as Salmonella by the host is primarily accomplished by the activation of Th1-mediated immune responses [7, 11, >>21<<, 45]. More recently, a few studies [41\u201343] have been interested in porcine antimicrobial peptides in the context of Salmonella infection. An antimicrobial activity has been demonstrated for porcine beta-defensin 2 (PBD-2) against various" ; ns1:mentions . _:b4178680 rdf:type ns1:Context ; rdf:value "The clearance of intracellular pathogens such as Salmonella by the host is primarily accomplished by the activation of Th1-mediated immune responses [7, 11, 21, >>45<<]. More recently, a few studies [41\u201343] have been interested in porcine antimicrobial peptides in the context of Salmonella infection. An antimicrobial activity has been demonstrated for porcine beta-defensin 2 (PBD-2) against various" ; ns1:mentions . _:b4178681 rdf:type ns1:Context ; rdf:value "More recently, a few studies [>>41<<\u201343] have been interested in porcine antimicrobial peptides in the context of Salmonella infection." ; ns1:mentions , , . _:b4178682 rdf:type ns1:Context ; rdf:value "Typhimurium [>>41<<]. By contrast, Arcobacter cryaerophilus and Salmonella Enteritidis, pathogenic bacteria with comparable adhesion and invasion characteristics, failed to increase PBD-2 mRNA expression." ; ns1:mentions . _:b4178683 rdf:type ns1:Context ; rdf:value "This model originally described in sheep [>>15<<] is an interesting methodology which allows, similarly to the SISP procedure, the in vivo infection of isolated jejunal segments with a dose of pathogens without removing the blood supply and innervation." ; ns1:mentions . _:b4178684 rdf:type ns4:Section ; dc:title "materials and methods" ; ns4:contains _:b4178688 , _:b4178689 , _:b4178690 , _:b4178685 , _:b4178686 , _:b4178687 . _:b4178685 rdf:type ns1:Context ; rdf:value "The Salmonella enterica subspecies enterica serovar Typhimurium strain SL1344 [>>23<<] was used in the current study. Bacteria were prepared freshly for the experiment by cultivation from a frozen stock at 37\u2009\u00B0C in Luria Bertani broth (LB:" ; ns1:mentions . _:b4178686 rdf:type ns1:Context ; rdf:value "To constitute the loops, a sterile 2\u20134\u2009m long segment of intestine was surgically prepared in the jejunum, where PP can be individualized, of 3 one-month-old piglets (for a detailed description of the surgical procedure see [>>15<<]). This \u201Cintestinal-segment\u201D was then subdivided into consecutive segments, designated as \u201Cloops\u201D (10\u201320\u2009cm long, 6 loops), that included a PP, or \u201Cinterspaces\u201D (20\u2013100\u2009cm long, 7 interspaces), that lacked a visible PP (Fig. 1). All" ; ns1:mentions . _:b4178687 rdf:type ns1:Context ; rdf:value "Moreover a quantitative real-time PCR (qPCR) directed against sipA [>>14<<] which is involved in the invasion of the bacteria showed a clear up-regulation of sipA mRNA expression in all the infected loops versus the control loops confirming the infection in Salmonella loops and the absence of bacteria in control" ; ns1:mentions . _:b4178688 rdf:type ns1:Context ; rdf:value "BW955277) and the 5\u2032 end of the porcine CCRL1, which was obtained using a 5\u2032 RACE template switching method [>>27<<] with the primer sets CCRL1GSP and CCRL1nGSP (Tab." ; ns1:mentions . _:b4178689 rdf:type ns1:Context ; rdf:value "Quantitative real-time PCR (qPCR) was performed using cDNA synthesized as previously described [>>29<<]. Diluted cDNA (40\u00D7) was combined with primer/probe sets and IQ SYBR Green Supermix (Bio-Rad, Hercules, California, USA) according to the manufacturer\u2019s recommendations." ; ns1:mentions . _:b4178690 rdf:type ns1:Context ; rdf:value "Samples were normalized internally using simultaneously the average cycle threshold (Ct) of Hypoxanthine PhosphoRibosyl-Transferase 1 (HPRT-1), Ribosomal Protein L 19 (RPL-19) and Tata Box Binding Protein 1 (TBP-1) [>>33<<] as references in each sample to avoid any artifact of variation in the target gene." ; ns1:mentions . _:b4178691 rdf:type ns4:Section ; dc:title "discussion" ; ns4:contains _:b4178728 , _:b4178729 , _:b4178730 , _:b4178731 , _:b4178732 , _:b4178733 , _:b4178734 , _:b4178735 , _:b4178720 , _:b4178721 , _:b4178722 , _:b4178723 , _:b4178724 , _:b4178725 , _:b4178726 , _:b4178727 , _:b4178736 , _:b4178737 , _:b4178738 , _:b4178739 , _:b4178740 , _:b4178741 , _:b4178742 , _:b4178696 , _:b4178697 , _:b4178698 , _:b4178699 , _:b4178700 , _:b4178701 , _:b4178702 , _:b4178703 , _:b4178692 , _:b4178693 , _:b4178694 , _:b4178695 , _:b4178712 , _:b4178713 , _:b4178714 , _:b4178715 , _:b4178716 , _:b4178717 , _:b4178718 , _:b4178719 , _:b4178704 , _:b4178705 , _:b4178706 , _:b4178707 , _:b4178708 , _:b4178709 , _:b4178710 , _:b4178711 . _:b4178692 rdf:type ns1:Context ; rdf:value "Several papers have focused recently on \u201Cscavenger receptors\u201D which are \u201Catypical\u201D receptors playing a role in scavenging or altering the localization of chemoattractant molecules such as chemokines and complement molecules [>>8<<, 10, 25]. The \u201Catypical\u201D receptor family comprised the receptors D6, the Duffy Antigen/Receptor for Chemokines and CCRL1/CCX-CKR [8, 10]." ; ns1:mentions . _:b4178693 rdf:type ns1:Context ; rdf:value "Several papers have focused recently on \u201Cscavenger receptors\u201D which are \u201Catypical\u201D receptors playing a role in scavenging or altering the localization of chemoattractant molecules such as chemokines and complement molecules [8, >>10<<, 25]. The \u201Catypical\u201D receptor family comprised the receptors D6, the Duffy Antigen/Receptor for Chemokines and CCRL1/CCX-CKR [8, 10]." ; ns1:mentions . _:b4178694 rdf:type ns1:Context ; rdf:value "Several papers have focused recently on \u201Cscavenger receptors\u201D which are \u201Catypical\u201D receptors playing a role in scavenging or altering the localization of chemoattractant molecules such as chemokines and complement molecules [8, 10, >>25<<]. The \u201Catypical\u201D receptor family comprised the receptors D6, the Duffy Antigen/Receptor for Chemokines and CCRL1/CCX-CKR [8, 10]." ; ns1:mentions . _:b4178695 rdf:type ns1:Context ; rdf:value "The \u201Catypical\u201D receptor family comprised the receptors D6, the Duffy Antigen/Receptor for Chemokines and CCRL1/CCX-CKR [>>8<<, 10]. CCRL1 was described in mice and humans but there was no data about this receptor in the pig [9, 16, 34, 37]. As previously shown, this receptor of CCL19, CCL21 and CCL25 is expressed in various tissues such as the duodenum, jejunum," ; ns1:mentions . _:b4178696 rdf:type ns1:Context ; rdf:value "The \u201Catypical\u201D receptor family comprised the receptors D6, the Duffy Antigen/Receptor for Chemokines and CCRL1/CCX-CKR [8, >>10<<]. CCRL1 was described in mice and humans but there was no data about this receptor in the pig [9, 16, 34, 37]. As previously shown, this receptor of CCL19, CCL21 and CCL25 is expressed in various tissues such as the duodenum, jejunum," ; ns1:mentions . _:b4178697 rdf:type ns1:Context ; rdf:value "CCRL1 was described in mice and humans but there was no data about this receptor in the pig [>>9<<, 16, 34, 37]." ; ns1:mentions . _:b4178698 rdf:type ns1:Context ; rdf:value "CCRL1 was described in mice and humans but there was no data about this receptor in the pig [9, >>16<<, 34, 37]. As previously shown, this receptor of CCL19, CCL21 and CCL25 is expressed in various tissues such as the duodenum, jejunum, ileum, colon, caecum, liver, thymus and heart [20, 34, 37]. At the protein level, the sequence of" ; ns1:mentions . _:b4178699 rdf:type ns1:Context ; rdf:value "CCRL1 was described in mice and humans but there was no data about this receptor in the pig [9, 16, >>34<<, 37]. As previously shown, this receptor of CCL19, CCL21 and CCL25 is expressed in various tissues such as the duodenum, jejunum, ileum, colon, caecum, liver, thymus and heart [20, 34, 37]. At the protein level, the sequence of porcine" ; ns1:mentions . _:b4178700 rdf:type ns1:Context ; rdf:value "CCRL1 was described in mice and humans but there was no data about this receptor in the pig [9, 16, 34, >>37<<]. As previously shown, this receptor of CCL19, CCL21 and CCL25 is expressed in various tissues such as the duodenum, jejunum, ileum, colon, caecum, liver, thymus and heart [20, 34, 37]. At the protein level, the sequence of porcine CCRL1" ; ns1:mentions . _:b4178701 rdf:type ns1:Context ; rdf:value "As previously shown, this receptor of CCL19, CCL21 and CCL25 is expressed in various tissues such as the duodenum, jejunum, ileum, colon, caecum, liver, thymus and heart [>>20<<, 34, 37]. At the protein level, the sequence of porcine CCRL1 is very close to the murine and human sequences with 85\u201388% identity suggesting similar function in swine. Data from in vitro studies suggest that CCRL1 may be able to act as a" ; ns1:mentions . _:b4178702 rdf:type ns1:Context ; rdf:value "As previously shown, this receptor of CCL19, CCL21 and CCL25 is expressed in various tissues such as the duodenum, jejunum, ileum, colon, caecum, liver, thymus and heart [20, >>34<<, 37]. At the protein level, the sequence of porcine CCRL1 is very close to the murine and human sequences with 85\u201388% identity suggesting similar function in swine. Data from in vitro studies suggest that CCRL1 may be able to act as a" ; ns1:mentions . _:b4178703 rdf:type ns1:Context ; rdf:value "As previously shown, this receptor of CCL19, CCL21 and CCL25 is expressed in various tissues such as the duodenum, jejunum, ileum, colon, caecum, liver, thymus and heart [20, 34, >>37<<]. At the protein level, the sequence of porcine CCRL1 is very close to the murine and human sequences with 85\u201388% identity suggesting similar function in swine. Data from in vitro studies suggest that CCRL1 may be able to act as a" ; ns1:mentions . _:b4178704 rdf:type ns1:Context ; rdf:value "Data from in vitro studies suggest that CCRL1 may be able to act as a chemokine scavenger, at least with one of its chemokine ligands, CCL19 [>>9<<]. Further experiments are required to characterize the function of this receptor in the pig and its relation with CCL25. Interestingly, in the current study, parallel decreases were observed for the mRNA expression of CCR9 and CCRL1" ; ns1:mentions . _:b4178705 rdf:type ns1:Context ; rdf:value "Typhimurium confirming a previously observed influence of intestinal bacteria on this chemokine mRNA expression [>>29<<]. The drastic and significant reduction in the mRNA expression of CCL25 suggests a potential strategy of S. Typhimurium to reduce lymphocyte homing to the intestine. Indeed, it is well known that Salmonella enterica is able to develop" ; ns1:mentions . _:b4178706 rdf:type ns1:Context ; rdf:value "Indeed, it is well known that Salmonella enterica is able to develop many strategies to escape T cell immunity (for a review see [>>4<<]). In contrast to the CCL25/CCR9-CCRL1 axis, the CCL28/CCR10 axis was not induced. The induction of CCL28 is different from that of CCL25 which is atypical with the involvement of caudal-related homeobox 2 [13, 29]." ; ns1:mentions . _:b4178707 rdf:type ns1:Context ; rdf:value "The induction of CCL28 is different from that of CCL25 which is atypical with the involvement of caudal-related homeobox 2 [>>13<<, 29]." ; ns1:mentions . _:b4178708 rdf:type ns1:Context ; rdf:value "The induction of CCL28 is different from that of CCL25 which is atypical with the involvement of caudal-related homeobox 2 [13, >>29<<]." ; ns1:mentions . _:b4178709 rdf:type ns1:Context ; rdf:value "Typhimurium in the pig [>>7<<, 21, 32]. To our knowledge, this is the first broad assessment at the mRNA level of Th orientations in the pig." ; ns1:mentions . _:b4178710 rdf:type ns1:Context ; rdf:value "Typhimurium in the pig [7, >>21<<, 32]. To our knowledge, this is the first broad assessment at the mRNA level of Th orientations in the pig." ; ns1:mentions . _:b4178711 rdf:type ns1:Context ; rdf:value "Typhimurium in the pig [7, 21, >>32<<]. To our knowledge, this is the first broad assessment at the mRNA level of Th orientations in the pig." ; ns1:mentions . _:b4178712 rdf:type ns1:Context ; rdf:value "The Th1 response orientation with a strong up-regulation of the mRNA expression of CXCL10 has been previously observed in both PP and GW [>>39<<]. The expression of CXCL10, a potent chemoattractant of Th1-type CD4+and NK cells [31], has been shown recently to be controlled by TLR4 in the context of Salmonella infection [22] and TLR4 mRNA expression was strongly up-regulated in our" ; ns1:mentions . _:b4178713 rdf:type ns1:Context ; rdf:value "The expression of CXCL10, a potent chemoattractant of Th1-type CD4+and NK cells [>>31<<], has been shown recently to be controlled by TLR4 in the context of Salmonella infection [22] and TLR4 mRNA expression was strongly up-regulated in our conditions." ; ns1:mentions . _:b4178714 rdf:type ns1:Context ; rdf:value "The expression of CXCL10, a potent chemoattractant of Th1-type CD4+and NK cells [31], has been shown recently to be controlled by TLR4 in the context of Salmonella infection [>>22<<] and TLR4 mRNA expression was strongly up-regulated in our conditions." ; ns1:mentions . _:b4178715 rdf:type ns1:Context ; rdf:value "For genes associated with inflammation, an induction of IL6, IL8 and TNF alpha mRNA was observed at 24\u2009h as previously shown in the pig [>>39<<]. However, in our conditions, IL1 beta and GM-CSF mRNA expressions were at very low levels with no increase in the infected tissues. In contrast to Th1 genes, Th2 and Th17 genes did not show any induction except for IL10 in the GW and" ; ns1:mentions . _:b4178716 rdf:type ns1:Context ; rdf:value "BAFF which is involved in the IgA CSR in humans and mice in both PP and lamina propria [>>6<<, 24, 26] was also up-regulated at the mRNA level in PP." ; ns1:mentions . _:b4178717 rdf:type ns1:Context ; rdf:value "BAFF which is involved in the IgA CSR in humans and mice in both PP and lamina propria [6, >>24<<, 26] was also up-regulated at the mRNA level in PP." ; ns1:mentions . _:b4178718 rdf:type ns1:Context ; rdf:value "BAFF which is involved in the IgA CSR in humans and mice in both PP and lamina propria [6, 24, >>26<<] was also up-regulated at the mRNA level in PP." ; ns1:mentions . _:b4178719 rdf:type ns1:Context ; rdf:value "These results are a little bit surprising considering reports in mice [>>18<<] showing that, at least, two main populations of dendritic cells are located in the gut:" ; ns1:mentions . _:b4178720 rdf:type ns1:Context ; rdf:value "The up-regulation was particularly obvious in the PP where NOD2 is highly expressed in the adult pig [>>36<<]. This observation is not surprising since PP M cells constitute a preferential site of entry for the bacteria [17, 19]. Surprisingly, TLR5 mRNA expression was down-regulated in both tissues. Abasht et al. made a similar observation with" ; ns1:mentions . _:b4178721 rdf:type ns1:Context ; rdf:value "This observation is not surprising since PP M cells constitute a preferential site of entry for the bacteria [>>17<<, 19]. Surprisingly, TLR5 mRNA expression was down-regulated in both tissues. Abasht et al. made a similar observation with Salmonella enterica serovar Enteritidis in chicken caecum and liver [1]. They hypothesized that the down-regulation" ; ns1:mentions . _:b4178722 rdf:type ns1:Context ; rdf:value "This observation is not surprising since PP M cells constitute a preferential site of entry for the bacteria [17, >>19<<]. Surprisingly, TLR5 mRNA expression was down-regulated in both tissues. Abasht et al. made a similar observation with Salmonella enterica serovar Enteritidis in chicken caecum and liver [1]. They hypothesized that the down-regulation of" ; ns1:mentions . _:b4178723 rdf:type ns1:Context ; rdf:value "Abasht et al. made a similar observation with Salmonella enterica serovar Enteritidis in chicken caecum and liver [>>1<<]. They hypothesized that the down-regulation of TLR5 RNA expression might be beneficial to protect host cells from over-stimulation by bacterial flagellin [1]. An explanation to this down-regulation could be, as observed with Borrelia" ; ns1:mentions . _:b4178724 rdf:type ns1:Context ; rdf:value "They hypothesized that the down-regulation of TLR5 RNA expression might be beneficial to protect host cells from over-stimulation by bacterial flagellin [>>1<<]. An explanation to this down-regulation could be, as observed with Borrelia burgdorferi, that the pathogen lipoprotein-mediated TLR2 stimulation could cause the down-regulation of TLR5 to escape the immune response [5]. TLR2 can act" ; ns1:mentions . _:b4178725 rdf:type ns1:Context ; rdf:value "An explanation to this down-regulation could be, as observed with Borrelia burgdorferi, that the pathogen lipoprotein-mediated TLR2 stimulation could cause the down-regulation of TLR5 to escape the immune response [>>5<<]. TLR2 can act synergistically with NOD2 and TLR4 while there is no evidence of such a synergism with TLR5 [38]." ; ns1:mentions . _:b4178726 rdf:type ns1:Context ; rdf:value "TLR2 can act synergistically with NOD2 and TLR4 while there is no evidence of such a synergism with TLR5 [>>38<<]." ; ns1:mentions . _:b4178727 rdf:type ns1:Context ; rdf:value "Antimicrobial peptides, NO and NK-lysin are known to be active against Salmonella [>>2<<, 3, 35, 43, 46]. In our conditions, we detected iNOS up-regulations in both PP and GW (P\u00A0<\u00A00.01) and PBD-2 and PMAP-37 only in PP." ; ns1:mentions . _:b4178728 rdf:type ns1:Context ; rdf:value "Antimicrobial peptides, NO and NK-lysin are known to be active against Salmonella [2, >>3<<, 35, 43, 46]. In our conditions, we detected iNOS up-regulations in both PP and GW (P\u00A0<\u00A00.01) and PBD-2 and PMAP-37 only in PP." ; ns1:mentions . _:b4178729 rdf:type ns1:Context ; rdf:value "Antimicrobial peptides, NO and NK-lysin are known to be active against Salmonella [2, 3, >>35<<, 43, 46]. In our conditions, we detected iNOS up-regulations in both PP and GW (P\u00A0<\u00A00.01) and PBD-2 and PMAP-37 only in PP." ; ns1:mentions . _:b4178730 rdf:type ns1:Context ; rdf:value "Antimicrobial peptides, NO and NK-lysin are known to be active against Salmonella [2, 3, 35, >>43<<, 46]. In our conditions, we detected iNOS up-regulations in both PP and GW (P\u00A0<\u00A00.01) and PBD-2 and PMAP-37 only in PP." ; ns1:mentions . _:b4178731 rdf:type ns1:Context ; rdf:value "Antimicrobial peptides, NO and NK-lysin are known to be active against Salmonella [2, 3, 35, 43, >>46<<]. In our conditions, we detected iNOS up-regulations in both PP and GW (P\u00A0<\u00A00.01) and PBD-2 and PMAP-37 only in PP." ; ns1:mentions . _:b4178732 rdf:type ns1:Context ; rdf:value "The up-regulation of iNOS sustains the anti-Salmonella role of NO [>>2<<]. In vitro, PBD-2 mRNA expression was increased 10-fold upon infection with S." ; ns1:mentions . _:b4178733 rdf:type ns1:Context ; rdf:value "Typhimurium [>>41<<] while in vivo PBD-2 was only slightly increased in some infected intestinal segments [42]." ; ns1:mentions . _:b4178734 rdf:type ns1:Context ; rdf:value "Typhimurium [41] while in vivo PBD-2 was only slightly increased in some infected intestinal segments [>>42<<]. In our conditions, PBD-2 mRNA was moderately induced only in the infected PP (P\u00A0<\u00A00.05) in accordance with Veldhuizen et al. observations [42]. However, the in vivo significance of these differences is difficult to appreciate because of" ; ns1:mentions . _:b4178735 rdf:type ns1:Context ; rdf:value "In our conditions, PBD-2 mRNA was moderately induced only in the infected PP (P\u00A0<\u00A00.05) in accordance with Veldhuizen et al. observations [>>42<<]. However, the in vivo significance of these differences is difficult to appreciate because of the low magnitude of the observed differences and the quite low starting level of expression. Further experiments are needed to definitely" ; ns1:mentions . _:b4178736 rdf:type ns1:Context ; rdf:value "NK-lysin, PBD-1 and PR-39 genes were not induced in both PP and GW 24\u2009h after the inoculations. This observation for PBD-1 is similar to previous reports [>>41<<, 42]." ; ns1:mentions . _:b4178737 rdf:type ns1:Context ; rdf:value "NK-lysin, PBD-1 and PR-39 genes were not induced in both PP and GW 24\u2009h after the inoculations. This observation for PBD-1 is similar to previous reports [41, >>42<<]." ; ns1:mentions . _:b4178738 rdf:type ns1:Context ; rdf:value "The mRNA expressions of the different genes were similar to other studies using young piglets [>>32<<, 39, 41]. Nevertheless, mRNA expressions could be different in adults as observed previously [12, 28] explaining differences in the response to the infection between young and adult pigs." ; ns1:mentions . _:b4178739 rdf:type ns1:Context ; rdf:value "The mRNA expressions of the different genes were similar to other studies using young piglets [32, >>39<<, 41]. Nevertheless, mRNA expressions could be different in adults as observed previously [12, 28] explaining differences in the response to the infection between young and adult pigs." ; ns1:mentions . _:b4178740 rdf:type ns1:Context ; rdf:value "The mRNA expressions of the different genes were similar to other studies using young piglets [32, 39, >>41<<]. Nevertheless, mRNA expressions could be different in adults as observed previously [12, 28] explaining differences in the response to the infection between young and adult pigs." ; ns1:mentions . _:b4178741 rdf:type ns1:Context ; rdf:value "Nevertheless, mRNA expressions could be different in adults as observed previously [>>12<<, 28] explaining differences in the response to the infection between young and adult pigs." ; ns1:mentions . _:b4178742 rdf:type ns1:Context ; rdf:value "Nevertheless, mRNA expressions could be different in adults as observed previously [12, >>28<<] explaining differences in the response to the infection between young and adult pigs." ; ns1:mentions . _:b388051567 rdf:type ns1:RelevantBibliographicResource . @prefix xsd: . _:b388051567 ns1:RelevantScore "8"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051568 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "8"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051569 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "6"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051570 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "6"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051571 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "5"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051572 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "5"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051573 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "4"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051574 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "4"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051575 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "4"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051576 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "4"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051577 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "4"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051578 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "3"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051579 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "3"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051580 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "3"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051581 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "3"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051582 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "3"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051583 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "3"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051584 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "3"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051585 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "3"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051586 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "3"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051587 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "3"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051588 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "3"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051589 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "3"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051590 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "3"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051591 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "3"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051592 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "3"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051593 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "3"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051594 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "3"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051595 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "3"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051596 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "3"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051597 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "3"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051598 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "3"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051599 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "3"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051600 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051601 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051602 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051603 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051604 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051605 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051606 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051607 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051608 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051609 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051610 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051611 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051612 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051613 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051614 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051615 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051616 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051617 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051618 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051619 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051620 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051621 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051622 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051623 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051624 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051625 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051626 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051627 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051628 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051629 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051630 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051631 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051632 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051633 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051634 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051635 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051636 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051637 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051638 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051639 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051640 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051641 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051642 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051643 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051644 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051645 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051646 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051647 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051648 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051649 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051650 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051651 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051652 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051653 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051654 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051655 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051656 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051657 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051658 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051659 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051660 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051661 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051662 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051663 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051664 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051665 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051666 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051667 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051668 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051669 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051670 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051671 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051672 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051673 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051674 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051675 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051676 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051677 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051678 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051679 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051680 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051681 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051682 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051683 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051684 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051685 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051686 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051687 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051688 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051689 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051690 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051691 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051692 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051693 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051694 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051695 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051696 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051697 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051698 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051699 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051700 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051701 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051702 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051703 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051704 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051705 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051706 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051707 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051708 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051709 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId . _:b388051710 rdf:type ns1:RelevantBibliographicResource ; ns1:RelevantScore "2"^^xsd:nonNegativeInteger ; ns1:hasRelevantPaperId .