. _:b421652938 "2"^^ . _:b421652605 . . _:b421652949 "2"^^ . _:b421652604 . . _:b421652948 "2"^^ . . _:b421652607 . . _:b421652937 . _:b421652951 "2"^^ . . _:b421652606 . _:b421652170 . . _:b421652996 . _:b421652950 "2"^^ . _:b421652601 . _:b421653414 . . _:b421652861 . _:b421652945 "2"^^ . _:b421652600 . _:b421651561 . _:b421652944 "2"^^ . _:b421652603 . _:b421651679 . . _:b421652947 "2"^^ . _:b421651689 . _:b421652602 . . _:b421652946 "2"^^ . _:b421653373 . _:b421652613 . _:b421653052 . . _:b421652957 "2"^^ . _:b421652612 . _:b421652956 "2"^^ . _:b421652615 . _:b421652956 . . . _:b421652959 "2"^^ . _:b421652614 . _:b421652193 . _:b421652958 "2"^^ . _:b421652609 . _:b421653603 . . _:b421653276 . _:b421652953 "2"^^ . _:b421652608 . _:b421652952 "2"^^ . _:b421652611 . _:b421652955 "2"^^ . _:b421652610 . . . _:b421652954 "2"^^ . _:b421652621 . _:b421652965 "2"^^ . _:b421652620 . _:b421653229 . . _:b421652964 "2"^^ . . _:b421652623 . _:b421652206 . _:b421652967 "2"^^ . _:b421652622 . . _:b421652503 . . _:b421652920 . _:b421652966 "2"^^ . _:b421652617 . _:b421652475 . _:b421652961 "2"^^ . _:b421652616 . _:b421651532 . _:b421652479 . _:b421652960 "2"^^ . _:b421652619 . . _:b421653331 . _:b421652963 "2"^^ . _:b421652618 . . _:b421653626 . . _:b421652962 "2"^^ . . _:b421653047 . _:b421652629 . _:b421652627 . _:b421652274 . _:b421652973 "2"^^ . _:b421652628 . _:b421653718 . _:b421652972 "2"^^ . _:b421651946 . _:b421652631 . _:b421652975 "2"^^ . _:b421652183 . _:b421652630 . _:b421652974 "2"^^ . _:b421652625 . _:b421652969 "2"^^ . _:b421652624 . _:b6691577 . _:b421652968 "2"^^ . _:b421652627 . _:b421652971 "2"^^ . _:b421652626 . . _:b6691570 "Other methods, including differential expression analysis, DNA-binding-site enrichment analysis8 and relevance network analysis>>34<< could not identify C/EBP\u03B2 and Stat3 as MRs (see Supplementary Note 2)." . _:b421652970 "2"^^ . _:b421652637 . _:b421651634 . _:b421652981 "2"^^ . _:b421652636 . _:b421651984 . _:b421652980 "2"^^ . _:b421652639 . . _:b421651632 . _:b6691569 . _:b421652983 "2"^^ . _:b421652638 . . _:b421653632 . . _:b421652982 "2"^^ . _:b421652117 . . _:b421651759 . _:b421652633 . _:b421652474 . _:b421652102 . _:b421652977 "2"^^ . . _:b421652632 . . _:b421652976 "2"^^ . _:b421652635 . _:b421652106 . _:b421652979 "2"^^ . . _:b421652634 . . _:b421653226 . . . _:b421652978 "2"^^ . _:b421652645 . _:b421653134 . _:b421652989 "2"^^ . _:b421652644 . . . _:b421652988 "2"^^ . _:b421652647 . _:b421652991 "2"^^ . _:b421652646 . _:b421652990 "2"^^ . _:b421652641 . _:b421652314 . _:b421652985 "2"^^ . _:b421652640 . _:b421652032 . . _:b421652984 "2"^^ . _:b421652643 . . _:b421653348 . _:b421651978 . _:b421652987 "2"^^ . _:b421651876 . _:b421652642 . _:b421653067 . . _:b421652986 "2"^^ . . _:b421652653 . _:b421653147 . _:b421651790 . . _:b421653072 . _:b421652652 . . . _:b421652655 . _:b421652454 . _:b421652252 . _:b421652654 . _:b421652649 . . _:b421652648 . _:b421651795 . _:b421652651 . _:b421652931 . _:b421652964 . _:b421653320 . _:b421652650 . _:b421652661 . _:b421653233 . _:b421653524 . _:b421652660 . _:b421653668 . _:b421653517 . _:b421652118 . _:b421652663 . _:b421653367 . _:b421652662 . _:b6691556 "each MGES gene was computed as follows: the log2 expression of the i-th MGES gene was considered as the response variable and the log2-expression of the TFs as the explanatory variables in the linear model log xi = \u2211 \u03B1ij log fj + \u03B2ij >>44<<. Here, fj represents the expression of the j-th TF in the model and the (\u03B1ij, \u03B2ij) are linear coupling coefficients computed by standard regression analysis." . _:b421652657 . . . . _:b421652656 . _:b421652659 . _:b421653456 . . _:b421652658 . . _:b421652669 . . _:b421652378 . _:b421652668 . _:b421653410 . . _:b421652671 . _:b421653061 . _:b421651738 . _:b421652670 . _:b421653595 . _:b421652950 . . _:b421652665 . . _:b421653703 . _:b6691575 . . . _:b421652664 . _:b421652667 . . _:b421652366 . . _:b421652666 . _:b421651968 . . . _:b421652677 . . _:b421651953 . _:b421652676 . . . _:b421652679 . . _:b421652678 . _:b421652673 . _:b421652672 . _:b421652778 . _:b421653523 . _:b421652675 . . _:b421651960 . _:b421651961 . _:b421651962 . _:b421651963 . _:b421652674 . _:b421651964 . _:b421651965 . _:b421651966 . _:b421651967 . _:b421652685 . _:b421651952 . _:b421652591 . _:b421651953 . _:b421651954 . _:b421651955 . _:b421652684 . _:b421651956 . _:b421652556 . _:b421651957 . . _:b421651958 . _:b421652657 . _:b421651959 . _:b421652687 . . . _:b421651641 . _:b421651944 . _:b421651945 . . . . _:b421651946 . . _:b421652686 . _:b421651947 . . _:b421651948 . _:b421651949 . _:b421651950 . _:b421651951 . _:b421653558 . _:b421652681 . _:b421651936 . _:b421651937 . _:b6691559 . _:b421651938 . _:b421651939 . _:b421652680 . _:b421651940 . _:b421651941 . _:b421651942 . _:b421651943 . _:b421652683 . _:b421651928 . . _:b421651929 . _:b421652796 . _:b421651930 . . . _:b421651931 . _:b421652682 . _:b421651932 . . _:b421651933 . _:b421651934 . _:b421651935 . _:b421652693 . . _:b421651920 . _:b421651921 . . . _:b421651922 . _:b421651923 . _:b421652692 . _:b421651924 . _:b421651925 . _:b421651926 . _:b421653018 . _:b421651927 . _:b421652695 . . _:b421651912 . _:b421651913 . _:b421653441 . _:b421651914 . _:b421651915 . _:b421652694 . . . _:b421651916 . _:b421651917 . _:b421651918 . _:b421652744 . _:b421651919 . _:b421652689 . _:b421651904 . _:b421651905 . . _:b421651906 . _:b421653507 . _:b421651907 . _:b421652688 . _:b421651908 . _:b421651909 . _:b421651910 . _:b421651911 . _:b421652691 . _:b421651896 . _:b421651897 . _:b421653504 . _:b421651898 . _:b421653740 . _:b421651899 . _:b421652690 . _:b421651900 . _:b421651901 . _:b421651902 . _:b421651903 . _:b421652701 . _:b421651888 . _:b421653527 . _:b421651889 . _:b421651890 . _:b421651891 . _:b421652700 . . _:b421651892 . _:b421652643 . _:b421652012 . . _:b421651893 . . . . _:b421651894 . _:b421651895 . _:b421652703 . _:b421651880 . _:b421651881 . _:b421651882 . _:b6691598 "we conducted an immunohistochemical analysis for C/EBP\u03B2 and active, phospho-Stat3 in human tumor specimens, and compared their expression with that of YKL40 (a well-established mesenchymal protein expressed in primary human GBM)21, >>32<< and with patient outcome in a collection of 62 GBMs (Supplementary Fig. 9)." . _:b421651883 . _:b421652702 . _:b421651884 . _:b421652614 . _:b421651885 . _:b421651886 . _:b421651887 . _:b421652697 . _:b421651992 . _:b421651872 . . _:b421652986 . _:b421651873 . _:b421651874 . . _:b421651875 . _:b421652696 . _:b421652603 . _:b421651876 . _:b421653011 . . _:b421651877 . _:b421651878 . . _:b421651879 . _:b421652699 . . _:b421651864 . _:b421651865 . _:b421651866 . _:b421651867 . _:b421652698 . _:b421651868 . . _:b421651869 . _:b421652553 . _:b421651870 . _:b421651871 . _:b421652709 . _:b421651856 . _:b421651857 . . _:b421651858 . _:b421651859 . _:b421652708 . _:b421651860 . _:b421651861 . _:b421651862 . _:b421651863 . _:b421652711 . . _:b421651578 . . _:b421651848 . _:b421651849 . _:b421651850 . _:b421651851 . _:b421652710 . . _:b421651852 . _:b421651853 . _:b421653542 . _:b421651854 . _:b421651855 . _:b421652705 . . _:b421651840 . _:b421651841 . _:b421651842 . _:b421651843 . _:b421653565 . _:b421652704 . _:b421651844 . _:b421651845 . _:b421652406 . _:b421651846 . . _:b421652707 . _:b421651847 . _:b421651832 . _:b421651833 . _:b421653066 . _:b421651834 . _:b421651835 . _:b421652706 . _:b421651836 . . _:b421651837 . _:b421651838 . _:b421651839 . _:b421652717 . _:b421651824 . _:b421651825 . _:b421652660 . _:b421651826 . _:b421651827 . _:b421652716 . _:b421651828 . _:b421651829 . _:b421651830 . _:b421651831 . _:b421652719 . _:b421651816 . _:b421651817 . _:b421651818 . _:b421652973 . _:b421651819 . _:b421652718 . . _:b421651820 . _:b421651821 . _:b421652574 . _:b421651822 . _:b421651823 . _:b421652713 . _:b421651808 . _:b421653055 . _:b421651809 . _:b421651810 . _:b421651811 . _:b421652712 . . _:b421651812 . _:b421651813 . _:b421651814 . _:b421651815 . _:b421652715 . . _:b421651800 . _:b421651801 . _:b421651802 . _:b421652712 . _:b421651803 . _:b421653270 . _:b421652714 . _:b421651804 . _:b421651805 . _:b421651806 . _:b421651807 . _:b421653191 . _:b421652725 . . . _:b421651792 . . _:b421651793 . _:b421651794 . . _:b421651795 . _:b421652724 . _:b421651796 . _:b421651797 . _:b421651798 . _:b421651799 . _:b421652727 . . _:b421651784 . . _:b421651785 . _:b421651786 . _:b421651787 . _:b421652726 . _:b421651588 . _:b421651788 . _:b421651789 . . . _:b421651790 . _:b421651791 . _:b421652721 . _:b421651776 . _:b421651777 . _:b421651778 . _:b421651779 . _:b421652720 . _:b421651780 . _:b421651781 . _:b421651782 . . _:b421652723 . _:b421651783 . _:b421651768 . _:b421652038 . _:b421651769 . _:b421651770 . _:b421651771 . _:b421652722 . . _:b421653173 . _:b421651772 . _:b421651773 . _:b421651774 . _:b421651775 . _:b421652733 . _:b421652672 . _:b421652333 . _:b421651760 . _:b421651761 . _:b421651762 . _:b421651763 . _:b421652732 . _:b421651764 . _:b421651939 . _:b421651765 . _:b421651766 . _:b421653731 . _:b421651767 . _:b421652735 . . _:b421651752 . _:b421651753 . _:b421651754 . _:b421651755 . _:b421652734 . _:b421652098 . _:b421651756 . _:b421651757 . _:b421651758 . _:b421651759 . _:b421652729 . _:b421651744 . _:b421651745 . _:b421651746 . _:b421651747 . _:b421652728 . _:b421651748 . _:b421651749 . _:b421651750 . _:b421652270 . _:b421651701 . _:b421652731 . _:b421651751 . _:b421651736 . _:b421651737 . . _:b421651719 . _:b421651738 . _:b421651739 . _:b421652977 . _:b421652730 . _:b421651740 . _:b421651741 . . _:b421651742 . . _:b421651743 . . _:b421653277 . _:b421651728 . _:b421651729 . _:b421651730 . _:b421651731 . _:b421651732 . _:b421651733 . _:b421651734 . _:b421652346 . _:b421651735 . _:b421653438 . _:b421653401 . _:b421651720 . _:b421651721 . _:b421651722 . _:b421652960 . _:b421651723 . _:b421651724 . _:b421651725 . _:b421652759 . _:b421651726 . _:b421651727 . . _:b421651712 . . _:b421651713 . _:b421651714 . _:b421651715 . . _:b421651716 . _:b421651717 . . _:b421651718 . _:b421651719 . _:b421651704 . _:b421652907 . _:b421651705 . _:b421651706 . . _:b421651707 . _:b421651708 . _:b421651709 . . _:b421651710 . _:b421651711 . _:b421651696 . _:b421651697 . _:b421651850 . _:b421651698 . _:b421651699 . _:b421651700 . _:b421651701 . _:b421651620 . _:b421651702 . _:b421651703 . _:b421653159 . _:b421651688 . _:b421651689 . . _:b421651690 . _:b421651691 . _:b421651692 . _:b421651693 . _:b421651694 . _:b421653312 . _:b421651695 . _:b421653629 . _:b421651680 . . _:b421651681 . _:b421651682 . _:b421651683 . _:b421651684 . _:b421651685 . _:b421651800 . _:b421651686 . . . _:b421651687 . _:b421651672 . _:b421651839 . _:b421651673 . _:b421651674 . _:b421652296 . _:b421651675 . _:b421652054 . _:b421651676 . _:b421651677 . _:b421651678 . _:b421651679 . _:b421651664 . _:b421651665 . _:b421651666 . _:b421651667 . _:b421651668 . _:b421651669 . _:b421652380 . _:b421651670 . _:b421651671 . _:b421651656 . _:b6691585 "ARACNe is an information theoretic approach for the inference of TF-target interactions from large sets of gene expression profiles9, 16, further refined to infer directed (i.e. causal) interactions>>12<<, 22 (see Methods)." . . _:b421652284 . . _:b421651657 . _:b421651658 . _:b421651659 . . _:b421651660 . _:b421651661 . _:b421651662 . _:b421651663 . _:b421653540 . _:b421651648 . _:b421651649 . . _:b421651650 . _:b421651651 . . _:b421651652 . . _:b421651653 . . . _:b421651654 . _:b421651655 . . . _:b421651640 . _:b421651641 . _:b421651642 . _:b421652290 . _:b421651643 . _:b421651644 . _:b421651645 . _:b421652019 . _:b421651646 . _:b421651647 . _:b421652265 . _:b421651632 . _:b421651633 . _:b421651634 . _:b421652210 . _:b421651635 . _:b421651636 . _:b421651637 . _:b421651638 . _:b421651639 . _:b421651624 . _:b421653432 . _:b421651625 . _:b421651626 . _:b421651627 . _:b421651628 . _:b421651629 . _:b421651630 . _:b421652689 . _:b421651631 . _:b421651616 . . _:b421651617 . _:b421651618 . _:b421651619 . _:b421651620 . _:b421651621 . _:b421651622 . _:b421651623 . _:b421651608 . _:b421652273 . . _:b421651609 . _:b421651610 . _:b421651611 . _:b421651612 . _:b421651613 . _:b421651614 . . _:b421651615 . _:b421651600 . _:b421651601 . . _:b421651602 . _:b421651603 . _:b421651604 . _:b421651605 . . _:b421651606 . _:b6691562 "Hybridization data was obtained with an iScan BeadArray scanner (Illumina) and pre-processed by variance stabilization and robust spline normalization implemented in the lumi package under the R-system>>49<<. Gene expression data have been deposited in GEO with the following accession numbers: GSE19113 for mouse and GSE19114 for human data." . _:b421651607 . _:b421651592 . _:b6691581 . _:b421651593 . _:b421651594 . _:b421651595 . _:b421652797 . _:b421651596 . _:b421651597 . _:b421651598 . . _:b421651599 . . _:b421651584 . _:b421651585 . _:b421651586 . _:b421651587 . _:b421651588 . _:b421651589 . _:b421651590 . _:b421651591 . _:b421651576 . _:b421651577 . _:b421651578 . _:b421651579 . _:b421651580 . _:b421651581 . . _:b421651582 . . _:b421652514 . _:b421651583 . _:b421651568 . _:b421651569 . _:b421651570 . _:b421651571 . _:b421651645 . _:b421651572 . _:b421651573 . _:b421652727 . _:b421651574 . . _:b421651575 . _:b421651560 . . _:b421651561 . _:b421651562 . _:b421651563 . _:b421651564 . _:b421653409 . _:b421651565 . _:b421651566 . _:b421651567 . _:b421651552 . _:b421651553 . _:b421651554 . _:b421651555 . . _:b421651556 . _:b421651557 . . _:b421651558 . _:b421652695 . _:b421651559 . _:b421651544 . _:b421651545 . . _:b421651546 . _:b421651547 . _:b421651548 . _:b421651549 . _:b421651550 . _:b421651881 . _:b421651551 . _:b421651536 . . _:b421651537 . _:b421651538 . . _:b421651539 . _:b421651540 . . _:b421651541 . . _:b421651542 . _:b421651543 . _:b421653424 . _:b421651528 . _:b421651529 . _:b421651530 . _:b421651531 . _:b421651532 . _:b421651721 . _:b421651533 . . _:b421651534 . _:b421651535 . . _:b421651943 . . _:b421651522 . . . _:b421651523 . _:b421651524 . _:b421651525 . _:b421651526 . _:b421651527 . . _:b421652680 . _:b421652502 . . . . _:b421652057 . _:b421651528 . _:b421653171 . _:b421653311 . . _:b421652176 . _:b421652756 . _:b421653513 . . . . _:b421653715 . . . _:b421653538 . . . _:b421652911 . _:b421652400 . . . _:b421651788 . . _:b421652421 . _:b421653036 . _:b421652472 . _:b421653110 . _:b421652473 . _:b421652474 . _:b421652475 . _:b421652476 . _:b421652584 . _:b421652477 . _:b421652478 . _:b421652479 . _:b421652464 . _:b421652465 . _:b421652466 . _:b421652467 . _:b421652253 . _:b421652468 . _:b421652469 . _:b421652470 . _:b421652728 . _:b421652471 . . . _:b421652456 . _:b421652457 . _:b421652844 . _:b421652458 . _:b421653443 . . _:b421652459 . _:b421652460 . . _:b421652461 . _:b421652462 . . . _:b421652463 . _:b421651976 . _:b421652448 . _:b421652449 . _:b421652696 . _:b421652450 . _:b421652451 . _:b421652452 . _:b421652453 . _:b421652454 . . _:b421652455 . _:b421652440 . _:b421652441 . _:b421652442 . _:b421652443 . _:b421652444 . . _:b421652445 . _:b421652446 . . _:b421652447 . _:b421652432 . _:b421652433 . _:b421652434 . _:b421652435 . _:b421652436 . . _:b421652828 . _:b421652437 . _:b421652438 . _:b421652439 . _:b421652424 . _:b421652425 . _:b421652426 . _:b421652427 . _:b421652428 . . _:b421651979 . _:b421652429 . . _:b421652430 . _:b421652431 . _:b421652416 . _:b421652417 . _:b421652418 . _:b421652419 . _:b421652420 . _:b421652421 . _:b421652422 . _:b421652423 . _:b421652408 . _:b421652409 . _:b421652410 . . _:b421652411 . _:b421652412 . _:b421652413 . _:b421653445 . _:b421652414 . _:b421652415 . _:b421652400 . _:b421652401 . _:b421652402 . _:b421652403 . _:b421652404 . _:b421652405 . _:b421652261 . _:b421652406 . . _:b421652407 . _:b421652392 . _:b421652373 . _:b421652393 . . _:b421652394 . _:b421651999 . _:b421652395 . _:b421652691 . _:b421652396 . _:b421652397 . _:b421652398 . _:b421653380 . _:b421651828 . _:b421651851 . _:b421652486 . _:b421652399 . _:b421652384 . _:b421652385 . _:b421652386 . _:b421652387 . _:b421652388 . _:b421652389 . _:b421652390 . . _:b421652391 . _:b421652231 . _:b421652376 . . _:b421652377 . _:b421652378 . _:b421652379 . _:b421652380 . . _:b421652381 . _:b421652382 . . _:b421652383 . _:b421652368 . _:b421653641 . . _:b421652369 . _:b421653076 . _:b421652370 . _:b421652371 . _:b421652372 . _:b421651928 . . _:b421651537 . _:b421652373 . _:b421652374 . _:b421652375 . . _:b421652410 . _:b421652360 . _:b421652361 . _:b421652362 . _:b421652875 . _:b421651813 . . . _:b421652363 . _:b421652364 . _:b421652365 . . _:b421652366 . _:b421652330 . _:b421651637 . _:b421652367 . _:b421652352 . _:b421653643 . . _:b421652353 . . _:b421652354 . _:b421652355 . _:b421652356 . _:b421652357 . _:b421652358 . _:b421652359 . _:b421652344 . _:b421652345 . . _:b421652346 . _:b421652347 . _:b421652348 . _:b421652507 . _:b421652349 . _:b421652932 . _:b421652350 . _:b421652351 . _:b421652336 . _:b421653578 . _:b421652337 . _:b421652338 . _:b421652339 . _:b421651746 . _:b421652340 . _:b421652341 . _:b421652342 . _:b421652343 . _:b421652234 . _:b421652328 . _:b421652478 . _:b421652329 . _:b421652330 . _:b421652331 . . . _:b421652332 . _:b421652333 . _:b421652334 . _:b421652335 . _:b421653097 . _:b421651623 . _:b421652320 . _:b421652321 . . _:b421652322 . _:b421652077 . _:b421652323 . _:b421652324 . _:b421652325 . _:b421652983 . _:b421652065 . . . _:b421652326 . _:b421652327 . _:b421652312 . _:b421652313 . _:b421652314 . _:b421652315 . _:b421652316 . _:b421652317 . . _:b421652318 . . _:b421652319 . _:b421652304 . _:b421652305 . _:b421652306 . _:b421652307 . _:b421652308 . _:b421652309 . _:b421652310 . _:b421653162 . _:b421652311 . _:b421652924 . _:b421652296 . _:b421653652 . _:b421652297 . _:b421652298 . . _:b421652299 . _:b421652300 . _:b421653398 . _:b421652301 . _:b421652302 . _:b421652303 . . _:b421652288 . _:b421652289 . . _:b421652290 . . _:b421653157 . _:b421652291 . _:b421652292 . . _:b421652293 . _:b421652294 . _:b421652295 . _:b421652058 . _:b421652280 . _:b421652281 . _:b421652282 . _:b421652283 . _:b421652284 . _:b421652285 . _:b421652157 . . _:b421652286 . . _:b421652287 . _:b421652272 . _:b421652273 . _:b421652274 . _:b421652275 . . . _:b421652276 . _:b421651652 . _:b421652277 . _:b421652278 . _:b421652279 . _:b421653579 . _:b421652264 . _:b421652265 . _:b6691588 . _:b421652266 . _:b421652267 . _:b421652268 . _:b421652269 . _:b421652270 . _:b421652271 . _:b421652256 . . _:b421652653 . . _:b421652257 . _:b421652258 . _:b421652259 . _:b421652260 . . . _:b421653351 . _:b421652261 . _:b421652262 . _:b421652263 . _:b421652220 . _:b421652248 . _:b421652405 . _:b421652249 . _:b421652250 . _:b421651530 . _:b421652251 . _:b421652252 . _:b421652631 . . _:b421653054 . _:b421652253 . _:b421652254 . _:b421652255 . _:b421652240 . _:b421652241 . _:b421652242 . _:b421652243 . _:b421652244 . . _:b421652245 . _:b421652246 . . _:b421652247 . _:b421652232 . . _:b421652233 . _:b421651830 . _:b421652851 . _:b421652234 . _:b421652235 . _:b421652236 . _:b421652575 . _:b421652237 . _:b421653563 . . _:b421652238 . . _:b421652239 . _:b421652224 . . _:b421652225 . _:b421652226 . . _:b421652227 . . _:b421652228 . _:b421652229 . _:b421652230 . _:b421652231 . _:b421652216 . _:b421652217 . _:b421652218 . _:b421652219 . . _:b421652220 . . _:b421652221 . _:b421652222 . _:b421652223 . _:b421652208 . _:b421652209 . _:b421652210 . . _:b421652211 . _:b421652212 . _:b421652068 . _:b421652213 . _:b421652214 . _:b421652775 . _:b421652215 . _:b421652200 . _:b421652201 . . _:b421652416 . _:b421652202 . _:b421652203 . _:b421652204 . _:b421652205 . _:b421652206 . _:b421652207 . _:b421651750 . _:b421652192 . _:b6691581 "from 176 gene expression profiles of grade III (anaplastic astrocytoma) and grade IV (GBM) samples previously classified into three molecular signature groups \u2013 proneural, proliferative, and mesenchymal (Supplementary Table 1a\u2013c)4, >>20<<, 21. ARACNe is an information theoretic approach for the inference of TF-target interactions from large sets of gene expression profiles9, 16, further refined to infer directed (i.e. causal) interactions12, 22 (see Methods)." . _:b421652193 . . _:b421652194 . _:b421652195 . _:b421652196 . _:b421653660 . _:b421652138 . _:b421652197 . _:b421652198 . _:b421652199 . _:b421652184 . _:b421652185 . _:b421653165 . _:b421652186 . _:b6691590 "Consistent with their previously reported activity24, >>25<<, Spearman correlation analysis revealed that five of these TFs are likely activators (Stat3, C/EBP, bHLH-B2, Runx1, and FosL2) and one is likely a repressor (ZNF238)." . _:b421652187 . . _:b421652188 . _:b421652189 . _:b421653286 . . _:b421652190 . _:b421652191 . . _:b421652176 . _:b421652177 . _:b421652178 . _:b421652919 . . _:b421652179 . _:b421652180 . . _:b421652855 . _:b421652181 . _:b421652182 . _:b421652183 . . _:b421652168 . _:b421653189 . _:b421652169 . _:b421653462 . . _:b421651900 . _:b421652170 . _:b421652171 . . _:b421652172 . _:b421652173 . . _:b421652174 . . _:b421652175 . _:b421652160 . _:b421652161 . _:b421652162 . _:b421652163 . _:b421651575 . . _:b421652164 . . _:b421652165 . _:b421652166 . _:b421652167 . _:b421652152 . _:b421652153 . _:b421652154 . _:b421652155 . _:b421652156 . _:b421652640 . _:b421652157 . _:b421653293 . _:b421652158 . _:b421652159 . _:b421652144 . _:b421652145 . _:b421652146 . . _:b421653381 . _:b421652147 . _:b421652148 . . _:b421652149 . . _:b421652150 . _:b421652151 . _:b421652136 . _:b421653319 . . _:b421652137 . _:b421652138 . . _:b421652139 . . _:b421652140 . _:b421652141 . _:b421653287 . . _:b421652142 . _:b421651815 . _:b421652143 . . . _:b421652128 . _:b421652129 . _:b421652130 . . _:b421652131 . _:b421652132 . . _:b421652133 . _:b421652134 . _:b421652135 . _:b421652120 . _:b421652121 . _:b421652141 . _:b421652122 . _:b421652123 . _:b421652124 . _:b421652125 . _:b421653024 . _:b421652126 . _:b421652127 . . _:b421652112 . _:b6691561 "QRT-PCR results were analyzed by the \u0394\u0394CT method>>48<< using 18S as housekeeping gene." . _:b421652113 . _:b421652114 . _:b421652115 . _:b421652116 . _:b421652117 . _:b421652118 . _:b421652119 . _:b421652104 . _:b421652105 . . _:b421652106 . _:b421652107 . _:b421652994 . _:b421652033 . _:b421652108 . _:b421652109 . _:b421652110 . _:b421652111 . . _:b421652096 . _:b421652097 . _:b421652098 . _:b421653747 . _:b421652099 . _:b421652100 . _:b421652101 . . _:b421652102 . _:b421652103 . _:b421652088 . _:b421652089 . _:b421653153 . _:b421652090 . _:b421651772 . . . _:b421652091 . _:b421652092 . _:b421652093 . _:b421652094 . _:b421652095 . _:b421652080 . _:b421652081 . _:b421652082 . _:b421652083 . _:b421653167 . _:b421652084 . _:b421652008 . . _:b421652085 . _:b421652086 . _:b421652087 . _:b421652072 . _:b421652073 . _:b421652074 . _:b421652075 . . . _:b421652076 . _:b421652077 . _:b421652078 . _:b421652079 . _:b421652064 . _:b421652065 . _:b421652320 . _:b421652066 . _:b421652067 . _:b421652068 . _:b421652069 . _:b421652070 . _:b421652071 . _:b421652056 . _:b421653488 . _:b421652057 . _:b421653255 . _:b421652058 . _:b421652059 . _:b421652060 . _:b421652061 . _:b421652062 . . _:b421652063 . _:b421652048 . _:b421652476 . . _:b421652049 . _:b421652050 . _:b421652051 . _:b421652052 . . _:b421652053 . . _:b421652054 . _:b421652055 . _:b421652040 . _:b421653506 . _:b421652041 . _:b421652042 . . _:b421652043 . _:b421652044 . _:b421652045 . _:b421652046 . _:b421652047 . _:b421652032 . _:b421652033 . _:b421652034 . _:b421652093 . _:b421652035 . _:b421652700 . _:b421652036 . . _:b421652037 . . _:b421652038 . . _:b421652039 . . _:b421652024 . . _:b421652025 . . _:b421652026 . _:b421652027 . . _:b421652028 . _:b421652029 . _:b421652030 . . _:b421652031 . _:b421652016 . _:b421653518 . _:b421652017 . . _:b421653379 . . _:b421652018 . _:b421652019 . _:b421652020 . _:b421652021 . _:b421652022 . _:b6691571 . _:b421652023 . _:b421652008 . _:b421652009 . . . _:b421652010 . _:b421652011 . _:b421652012 . . _:b421652013 . . _:b421652014 . . . _:b421652015 . _:b421652000 . _:b421652001 . _:b421652002 . _:b421652003 . _:b421652004 . _:b421652005 . _:b421652819 . _:b421652006 . _:b421652007 . _:b421653580 . _:b421651992 . _:b421651993 . _:b421651994 . _:b421651995 . _:b421651996 . _:b421651997 . _:b6691575 "Primary NSCs were isolated from E13.5 mouse telencephalon and cultured in the presence of FGF-2 and EGF as described>>42<<. Differentiation was induced by culturing NSCs in NSC medium without EGF and FGF-2." . _:b421652343 . _:b421651998 . _:b421651681 . _:b421651999 . _:b421651984 . _:b421652048 . . _:b421651985 . _:b421651986 . _:b421651987 . _:b421651988 . _:b421651989 . _:b421652847 . _:b421651582 . _:b421651990 . _:b421651991 . _:b421651976 . . . _:b421651977 . _:b421651904 . _:b421651978 . _:b421651979 . _:b421651980 . _:b421652304 . _:b421651981 . . _:b421651982 . _:b421651983 . _:b421651968 . _:b421653114 . _:b421651723 . _:b421651969 . _:b421651970 . _:b421651971 . _:b421651972 . _:b421651973 . _:b421651974 . _:b421651975 . . _:b421652853 . _:b421653696 . _:b421652063 . . . _:b421651997 . _:b421651546 . . . _:b421653531 . _:b421653082 . _:b421652317 . . _:b421653701 . _:b421651694 . _:b421652326 . . . _:b421652192 . . _:b421652146 . . _:b421651786 . _:b421652831 . . _:b421653339 . _:b421651576 . . _:b421652783 . _:b421653026 . _:b421651982 . _:b421651929 . _:b421652687 . _:b421652941 . _:b421652468 . _:b421652655 . _:b421652109 . . . _:b421653258 . _:b421651572 . . . . . . . . . . _:b421653115 . _:b421651826 . . . . _:b421652257 . _:b421652862 . . . _:b421652898 . . _:b421651711 . _:b421652692 . _:b421652966 . . _:b421651864 . _:b421653057 . _:b421652303 . . . . _:b421653647 . . . _:b421651974 . . . _:b421653240 . . _:b421653127 . _:b421652860 . . . . _:b421653013 . _:b421652230 . . . . . . . . _:b421652752 . . . _:b421653732 . _:b421652073 . _:b421653768 . . _:b421653295 . . _:b421652384 . _:b421651550 . . . . . _:b421652438 . _:b421653154 . . _:b421651969 . _:b421652207 . . . . _:b421652398 . . _:b421652445 . _:b421653431 . _:b421651806 . . _:b421652596 . . . . . _:b421652740 . . . _:b421652918 . _:b421653624 . _:b421652151 . . . . . _:b421652169 . . . _:b6691564 . . _:b421653368 . _:b6691566 . . _:b421651923 . . . . _:b6691572 . . . _:b421653717 . _:b421652896 . _:b421652250 . _:b421653529 . _:b421653096 . _:b421652685 . _:b421652126 . . . _:b6691563 . . _:b421651574 . . _:b421653688 . . _:b421653515 . _:b421653372 . _:b421651811 . _:b421653640 . . . . _:b421652059 . . . _:b421652367 . _:b6691580 "from 176 gene expression profiles of grade III (anaplastic astrocytoma) and grade IV (GBM) samples previously classified into three molecular signature groups \u2013 proneural, proliferative, and mesenchymal (Supplementary Table 1a\u2013c)>>4<<, 20, 21. ARACNe is an information theoretic approach for the inference of TF-target interactions from large sets of gene expression profiles9, 16, further refined to infer directed (i.e. causal) interactions12, 22 (see Methods)." . . _:b421651571 . _:b421651524 . . _:b421653370 . _:b421652673 . _:b421652142 . . _:b421652120 . . . _:b421652972 . . . _:b421651619 . . _:b421653007 . _:b421652227 . . . . . _:b6691579 "We thus used the ARACNe algorithm>>9<< to assemble a genome-wide repertoire of HGGs-specific transcriptional interactions (the HGG-interactome) from 176 gene expression profiles of grade III (anaplastic astrocytoma) and grade IV (GBM) samples previously classified into three" . _:b421652422 . _:b421652255 . . _:b421653677 . _:b421652891 . _:b421653702 . _:b421652801 . . . _:b421652922 . _:b421653117 . . . _:b421653690 . _:b421653536 . . _:b421652371 . _:b421653032 . _:b421653584 . . _:b421652733 . _:b421652121 . _:b421653546 . . . _:b421652228 . . . _:b421652036 . . . . _:b421652224 . . . . _:b421652863 . . _:b421652072 . . _:b421651950 . _:b421653681 . . . _:b421653010 . . _:b421652236 . . . _:b421651911 . . _:b421653673 . _:b421652506 . _:b421652293 . _:b421652133 . _:b421652554 . . _:b421652841 . . _:b421653730 . . _:b421652929 . _:b421651798 . _:b421653184 . _:b421652446 . _:b421652162 . _:b421652205 . _:b421652184 . _:b421651661 . . _:b421652218 . _:b421653663 . _:b421652339 . . _:b421652520 . . . . . . _:b421651792 . _:b421653508 . . . _:b421652480 . _:b421651658 . _:b421652263 . _:b421651857 . _:b421652822 . . _:b421653503 . . _:b421653526 . _:b421651672 . . _:b421653402 . _:b421652883 . . _:b421652355 . _:b421651860 . . . _:b421652145 . _:b421653745 . _:b6691595 . . . . _:b421652420 . . . . _:b421653260 . . _:b421652724 . . . . . _:b421652616 . _:b421652168 . _:b421653299 . _:b421653205 . _:b421652598 . _:b421652568 . _:b421653600 . . . _:b421651895 . _:b421653511 . _:b6691596 . _:b421652541 . _:b421653363 . _:b421653621 . _:b421652798 . _:b6691591 . _:b421652913 . . . . . _:b421652382 . . . . _:b421653396 . . . _:b421652522 . . . _:b421653068 . . _:b421653637 . . . _:b421653758 . _:b421653541 . _:b421651836 . . _:b421652271 . . . . . _:b421652513 . _:b421652246 . _:b421651670 . _:b421652413 . . _:b6691583 . . . _:b421653711 . . _:b421652593 . _:b421653416 . . . _:b421652156 . _:b6691579 . . . _:b421651957 . . _:b421653051 . _:b421653676 . . _:b421651643 . . . . . . . . _:b421652607 . . . _:b421652894 . . . . . . . . _:b421652662 . . _:b421653500 . _:b421653586 . . _:b421653254 . _:b421653231 . _:b421652905 . _:b421651859 . . . . _:b421653030 . . _:b421653103 . _:b421653044 . . . _:b421652424 . . . . . _:b421652451 . . _:b421653209 . _:b421652747 . _:b421651931 . _:b421653267 . _:b421653297 . . _:b421653452 . . _:b421652414 . _:b421651935 . _:b6691555 "First, candidate interactions between a TF (x) and its potential target (y) are identified by computing pairwise mutual information, MI[x; y], using a Gaussian kernel estimator>>12<< and by thresholding the mutual information based on the null-hypothesis of statistical independence (p < 0.05 Bonferroni corrected for the number of tested pairs)." . _:b6691588 "C/EBP\u03B2 and C/EBP\u03B4 were grouped as they form stoichiometric homo and heterodimers with identical DNA binding specificity and redundant transcriptional activity>>23<<. We thus use the term C/EBP to indicate the TF complex with the union of their targets as the corresponding regulon. Consistent with their previously reported activity24, 25, Spearman correlation analysis revealed that five of these TFs" . . . . _:b421652472 . . . . _:b421651590 . . _:b421652318 . . _:b6691596 "c/ebp\u00CE\u00B2 and stat3 are essential for mesenchymal transformation and glioma aggressiveness" . . _:b421651945 . . _:b421653330 . . _:b421651959 . . _:b421652495 . . _:b421651580 . . _:b421653016 . _:b421652315 . _:b421653582 . . _:b6691588 . . _:b6691589 . _:b421652993 . _:b421653035 . _:b6691590 . _:b421652427 . _:b6691591 . . _:b421651732 . _:b421653098 . _:b6691584 . _:b421652097 . . _:b6691585 . . . _:b6691586 . _:b6691587 . . _:b421652163 . _:b421652807 . _:b421652644 . _:b421653343 . . _:b421652094 . _:b6691596 . _:b6691597 . _:b421653264 . _:b421651680 . . _:b6691598 . _:b421652794 . . . . _:b6691592 . _:b421651942 . . _:b6691593 . . _:b421651858 . _:b6691594 . . _:b421652393 . _:b421651940 . . _:b6691595 . _:b421653569 . _:b421653003 . _:b421652245 . _:b421653547 . . . . . . _:b421653657 . . _:b421653038 . . . _:b421652481 . _:b421652706 . _:b421651844 . . _:b421653088 . . _:b421653121 . _:b6691567 . . . _:b421653559 . _:b421653704 . . _:b6691578 . _:b421652377 . _:b421653602 . . . . . _:b6691574 . . _:b421653070 . . _:b421652533 . _:b421652493 . _:b421652460 . _:b421652874 . _:b421652639 . _:b421653483 . _:b421653534 . . . . _:b421651636 . . . _:b421652087 . _:b421651799 . _:b6691551 . . _:b421653385 . _:b421652342 . _:b421653131 . _:b421652016 . . _:b421653664 . . . _:b421653744 . _:b421652820 . . . _:b421651663 . . _:b421651919 . _:b421653575 . . . _:b421652031 . . _:b421653265 . . _:b421653208 . _:b421652360 . . _:b421651926 . . _:b421652889 . . . . _:b421652368 . . . . _:b421652028 . _:b421652790 . . _:b421653244 . _:b421653759 . . . . . . . . . . _:b421653535 . . _:b421652791 . . . _:b421651608 . _:b421652997 . _:b421652704 . _:b421653590 . _:b421651821 . _:b421652376 . _:b421651899 . _:b421651818 . _:b421653448 . _:b421652547 . . _:b421652991 . . . . . . . . _:b421651880 . _:b421653362 . _:b421653303 . _:b421651949 . . . . _:b421652988 . _:b421651712 . . . . _:b421653377 . _:b421653261 . . _:b421653716 . _:b421653371 . . . . . _:b421651965 . _:b421653174 . _:b421653081 . . _:b421653080 . . _:b421653548 . . . . _:b421652113 . . _:b421652280 . . _:b421652044 . _:b421653090 . _:b421652014 . _:b421653364 . . _:b421652665 . . _:b421651535 . . . _:b421651525 . . . . _:b421652992 . _:b421652897 . . . _:b421652399 . _:b421652758 . _:b421652287 . . _:b421652516 . _:b6691593 . . _:b421651699 . _:b421652492 . . . _:b421652052 . _:b421652127 . _:b421651948 . . . . _:b421653084 . . . _:b421653750 . . _:b421652238 . . _:b421651783 . _:b421652707 . _:b421651695 . . . _:b421651927 . . . _:b421652955 . _:b421652912 . . _:b421653736 . . _:b421652843 . _:b421652275 . . . _:b421653646 . . _:b421652854 . _:b421653667 . _:b421653769 . _:b421653608 . _:b421651522 . . . _:b421653767 . . _:b421652624 . _:b421653222 . . _:b421653023 . _:b421653650 . _:b421651856 . _:b421651635 . _:b421653182 . _:b421653315 . _:b421652456 . . . _:b421653689 . . _:b421652583 . . _:b421651868 . _:b421652842 . _:b421652150 . . . . . . . . _:b421653235 . _:b421652204 . _:b421653028 . . . _:b421652661 . . . _:b421651988 . . _:b421653464 . . _:b421652749 . . _:b421652332 . . . . . _:b421652147 . _:b421653289 . _:b6691558 . _:b421652899 . . . . . _:b421652449 . _:b421653190 . . . . _:b421651730 . . . _:b421652817 . _:b421653735 . . _:b421652025 . . . _:b421652976 . . . _:b421652835 . _:b421653166 . . _:b421653350 . . _:b421653705 . _:b421652566 . _:b421653078 . _:b421651808 . _:b421653757 . _:b421651924 . . _:b421652806 . . _:b421653491 . _:b421652654 . . _:b421652018 . _:b421653230 . _:b421652101 . _:b421651604 . . _:b421652212 . _:b421652543 . . _:b421652237 . . _:b421651812 . _:b421652415 . . . . . . _:b421653301 . _:b421652736 . . . _:b421651598 . _:b421652128 . . . . _:b421652217 . . _:b421653015 . _:b421651673 . . . . . _:b421652681 . . . . _:b421652761 . _:b421652324 . _:b421653622 . _:b421652483 . . _:b421652776 . _:b421651829 . . _:b421653427 . _:b421651973 . . _:b421653501 . _:b421653671 . _:b421652523 . _:b421652677 . . _:b421653386 . . . _:b6691589 "Consistent with their previously reported activity>>24<<, 25, Spearman correlation analysis revealed that five of these TFs are likely activators (Stat3, C/EBP, bHLH-B2, Runx1, and FosL2) and one is likely a repressor (ZNF238)." . _:b421652258 . _:b421652519 . _:b421651814 . _:b421651779 . . _:b421651961 . _:b421652610 . . . _:b421653369 . _:b421653086 . _:b421653723 . _:b421652784 . . _:b421653043 . . . _:b421652067 . . _:b421652222 . _:b421653124 . _:b421652350 . _:b421652792 . _:b421653106 . _:b421651527 . . . . _:b421653709 . _:b421651781 . _:b421653313 . _:b421651591 . . _:b421652085 . . . . . _:b421652818 . . _:b421653451 . . _:b421652781 . _:b421652171 . . . . . . _:b421652617 . . _:b421652702 . . _:b421652602 . _:b421653227 . _:b421652002 . _:b421651852 . . . . . _:b421652430 . . . _:b421652885 . . . . . . . . _:b421652089 . _:b6691567 "discussion" . _:b421651921 . . _:b421651897 . . _:b421653417 . _:b421653310 . . . _:b421651626 . . _:b421651566 . _:b421652564 . _:b421653158 . _:b421653486 . . _:b421652323 . _:b421651831 . _:b421652531 . . _:b421653497 . . _:b421652865 . . . _:b421653557 . _:b421651540 . _:b421653607 . . _:b421651903 . _:b421653554 . . _:b421653328 . . _:b421652248 . . _:b421652433 . _:b421653591 . _:b421652723 . . . _:b421651602 . _:b421651805 . _:b421652319 . . . _:b6691554 "Expression profiles used in the analysis were previously characterized using Affymetrix HU-133A microarrays and preprocessed by MAS 5.0 normalization procedure>>4<<. First, candidate interactions between a TF (x) and its potential target (y) are identified by computing pairwise mutual information, MI[x; y], using a Gaussian kernel estimator12 and by thresholding the mutual information based on the" . _:b421653100 . _:b421653499 . _:b421653263 . . _:b421652789 . _:b421653178 . _:b421652815 . _:b421653354 . _:b421651907 . _:b421652948 . _:b421652488 . . . . _:b421653140 . . _:b421652095 . _:b421652795 . _:b421652510 . _:b421653627 . . _:b421652935 . _:b421651933 . . _:b421653612 . _:b421652466 . _:b421652975 . . . . . _:b421652392 . _:b421651748 . _:b421652763 . . _:b421652751 . . . _:b421653572 . . _:b421652611 . _:b421653487 . . _:b421652779 . . . _:b421652005 . . . _:b421653256 . . _:b421652131 . . _:b421652364 . _:b421653048 . . . . _:b421652587 . _:b421652811 . _:b421652409 . . . _:b421653589 . . _:b421653039 . _:b421652017 . . . . . . _:b421653395 . . . . _:b421651832 . _:b6691592 . . _:b421653724 . _:b421652020 . . . _:b421653298 . _:b421653408 . . _:b421653713 . _:b421652104 . _:b421653466 . _:b421653332 . . . . . _:b6691577 "The statistical significance of the enrichment of a ranked list of genes in a smaller set of genes was determined as described>>43<<." . . _:b421652967 . . . . . _:b421652457 . _:b421651615 . . _:b421653213 . . _:b421653661 . _:b421653545 . . . _:b6691568 . . . _:b421651780 . _:b421652620 . _:b421651794 . . _:b421652511 . _:b421652930 . _:b421651684 . . _:b421651872 . . . _:b421652725 . . _:b421651973 "4"^^ . _:b421652172 . _:b421651972 "4"^^ . _:b421652029 . . . _:b421651975 "4"^^ . . _:b421651887 . _:b421651624 . . _:b421651974 "4"^^ . _:b421652356 . _:b421651969 "4"^^ . _:b421652075 . . . _:b421651968 "4"^^ . _:b421651971 "4"^^ . . _:b421653755 . _:b421651970 "4"^^ . _:b421653592 . _:b421653666 . _:b421651981 "4"^^ . _:b421651980 "4"^^ . _:b421653050 . _:b421653707 . . _:b421652867 . _:b421652000 . _:b421651983 "4"^^ . _:b421651982 "4"^^ . _:b421653034 . _:b421651977 "4"^^ . . . _:b421651976 "4"^^ . . _:b421652154 . _:b421651979 "4"^^ . _:b421652628 . . _:b421651978 "4"^^ . _:b421653187 . _:b421653771 . _:b421651989 "4"^^ . . . _:b421651702 . _:b421651988 "4"^^ . . _:b421652379 . _:b421651991 "4"^^ . . _:b421652178 . _:b421651990 "4"^^ . . _:b421651595 . _:b421651985 "4"^^ . . _:b421651984 "4"^^ . _:b421653359 . . _:b421653206 . _:b421652349 . _:b421651987 "4"^^ . _:b421651986 "4"^^ . . _:b421652167 . _:b421651997 "3"^^ . _:b421652470 . _:b421653435 . _:b421651996 "3"^^ . . _:b421652934 . _:b421651999 "3"^^ . _:b421651998 "3"^^ . . _:b421651993 "3"^^ . _:b421651884 . . _:b421651992 "3"^^ . . _:b421651995 "3"^^ . . _:b421651994 "3"^^ . . _:b421652216 . _:b421652005 "3"^^ . _:b421652004 "3"^^ . _:b421653699 . . . _:b421652007 "3"^^ . . _:b421651607 . _:b421652006 "3"^^ . _:b421652613 . _:b421651775 . _:b421652001 "3"^^ . . _:b421652000 "3"^^ . _:b421652003 "3"^^ . _:b421652963 . . _:b421653139 . _:b421652002 "3"^^ . _:b421652013 "3"^^ . _:b421651609 . _:b421652012 "3"^^ . _:b421651909 . . . _:b421652015 "3"^^ . _:b421653037 . _:b421652014 "3"^^ . _:b421652634 . . _:b421653763 . . _:b421652009 "3"^^ . . . _:b421652008 "3"^^ . . _:b421652011 "3"^^ . . _:b421652010 "3"^^ . _:b421651837 . _:b421652021 "3"^^ . . _:b421652020 "3"^^ . _:b421652023 "3"^^ . _:b421651625 . _:b421653033 . . _:b421652022 "3"^^ . _:b421652017 "3"^^ . . . . _:b421652016 "3"^^ . _:b421652739 . . _:b421652785 . _:b421652019 "3"^^ . _:b421652697 . . _:b421652558 . _:b421652018 "3"^^ . _:b421652029 "3"^^ . _:b421652028 "3"^^ . _:b421653021 . _:b421652629 . _:b421652055 . _:b421652515 . . _:b421652031 "3"^^ . . . _:b421652266 . . _:b421652030 "3"^^ . _:b421652025 "3"^^ . _:b421651647 . _:b421652039 . _:b421652084 . _:b421652024 "3"^^ . _:b421652027 "3"^^ . _:b421652026 "3"^^ . . _:b421653762 . _:b421652129 . _:b421651739 . _:b421652037 "3"^^ . _:b421652328 . _:b421652036 "3"^^ . _:b421652039 "3"^^ . _:b421652038 "3"^^ . _:b421653133 . _:b421651621 . . _:b421652033 "3"^^ . _:b421653509 "2"^^ . . _:b421652387 . _:b421652032 "3"^^ . _:b421653508 "2"^^ . . . _:b421653511 "2"^^ . _:b421652035 "3"^^ . _:b421652487 . _:b421652034 "3"^^ . _:b421653510 "2"^^ . _:b421652892 . . _:b421653168 . . _:b421653505 "2"^^ . _:b421652045 "3"^^ . . . _:b421653504 "2"^^ . _:b421652044 "3"^^ . . . _:b421652047 "3"^^ . _:b421653507 "2"^^ . _:b421653136 . _:b421652046 "3"^^ . _:b421653506 "2"^^ . _:b421652041 "3"^^ . _:b421653517 "2"^^ . _:b421652040 "3"^^ . _:b421653516 "2"^^ . _:b421652043 "3"^^ . _:b421653519 "2"^^ . . . _:b421652810 . _:b421652042 "3"^^ . _:b421653518 "2"^^ . . _:b421653219 . _:b421652053 "3"^^ . _:b421653513 "2"^^ . _:b421652876 . . _:b421652374 . . _:b421652052 "3"^^ . _:b421653512 "2"^^ . . . _:b421652055 "3"^^ . _:b421653515 "2"^^ . . _:b421653514 "2"^^ . _:b421652054 "3"^^ . . _:b421652721 . . . _:b421653525 "2"^^ . _:b421652049 "3"^^ . . . . _:b421652048 "3"^^ . _:b421653524 "2"^^ . . . _:b421653527 "2"^^ . _:b421652051 "3"^^ . _:b421652050 "3"^^ . _:b421653658 . _:b421653526 "2"^^ . _:b421652229 . _:b421652565 . _:b421652061 "3"^^ . _:b421653521 "2"^^ . _:b421652228 . . . . _:b421653520 "2"^^ . _:b421652231 . _:b421652060 "3"^^ . _:b421651659 . _:b421652443 . _:b421652063 "3"^^ . _:b421653523 "2"^^ . _:b421652230 . . _:b421653288 . _:b421652062 "3"^^ . _:b421653522 "2"^^ . _:b421652225 . _:b421653726 . _:b421653272 . _:b421652057 "3"^^ . _:b421653533 "2"^^ . _:b421652224 . _:b421652056 . _:b421653562 . _:b421652056 "3"^^ . _:b421653532 "2"^^ . _:b421652825 . _:b421652227 . _:b421652059 "3"^^ . _:b421653535 "2"^^ . _:b421652226 . . . _:b421653534 "2"^^ . _:b421652237 . _:b421652058 "3"^^ . _:b421651769 . _:b421652069 "3"^^ . _:b421653529 "2"^^ . _:b421652236 . _:b421651971 . _:b421653528 "2"^^ . _:b421652239 . _:b421652068 "3"^^ . _:b421651760 . _:b421652071 "3"^^ . _:b421653531 "2"^^ . _:b421652238 . _:b421652070 "3"^^ . _:b421653530 "2"^^ . _:b421652233 . _:b421652065 "3"^^ . _:b421653541 "2"^^ . _:b421652232 . _:b421652064 "3"^^ . _:b421653540 "2"^^ . _:b421652235 . _:b421652067 "3"^^ . _:b421653543 "2"^^ . _:b421652234 . _:b421652530 . _:b421652953 . _:b421652066 "3"^^ . _:b421653542 "2"^^ . _:b421653077 . _:b421652245 . . _:b421652023 . _:b421652077 "3"^^ . _:b421653537 "2"^^ . _:b421652244 . . _:b421653536 "2"^^ . _:b421652247 . _:b421652076 "3"^^ . _:b421652979 . . _:b421653533 . . _:b421652079 "3"^^ . _:b421653539 "2"^^ . _:b421652246 . . _:b421652467 . _:b421652078 "3"^^ . _:b421653538 "2"^^ . _:b421652241 . _:b421652073 "3"^^ . _:b421653549 "2"^^ . _:b421652240 . . _:b421652773 . _:b421652132 . . _:b421653548 "2"^^ . _:b421652243 . _:b421652072 "3"^^ . . . _:b421653551 "2"^^ . _:b421652242 . _:b421652075 "3"^^ . _:b421651889 . . . _:b421652074 "3"^^ . _:b421653550 "2"^^ . _:b421652253 . _:b421652085 "3"^^ . _:b421653545 "2"^^ . _:b421652252 . _:b421651841 . _:b421653544 "2"^^ . _:b421652255 . _:b421652084 "3"^^ . _:b421653266 . _:b421652491 . . _:b421652087 "3"^^ . _:b421653547 "2"^^ . _:b421652254 . . . _:b421653430 . _:b421651922 . _:b421653546 "2"^^ . _:b421652249 . _:b421652086 "3"^^ . . _:b421653567 . _:b421652437 . . _:b421653557 "2"^^ . _:b421652248 . _:b421652081 "3"^^ . _:b421651573 . . _:b421653556 "2"^^ . _:b421652251 . _:b421652148 . _:b421652080 "3"^^ . _:b421652083 "3"^^ . _:b421653559 "2"^^ . _:b421652250 . _:b421651691 . _:b421652082 "3"^^ . _:b421653558 "2"^^ . _:b421652261 . . _:b421652093 "3"^^ . _:b421653553 "2"^^ . _:b421652260 . . _:b421653573 . . _:b421652027 . _:b421652092 "3"^^ . _:b421653552 "2"^^ . _:b421652263 . . . _:b421652095 "3"^^ . _:b421653555 "2"^^ . _:b421652262 . . _:b421652094 "3"^^ . _:b421653554 "2"^^ . _:b421652257 . _:b421652089 "3"^^ . _:b421653565 "2"^^ . _:b421652256 . _:b421652710 . _:b421652088 "3"^^ . _:b421653564 "2"^^ . _:b421652259 . _:b421652001 . _:b421652091 "3"^^ . _:b421653567 "2"^^ . _:b421652258 . _:b421651660 . . _:b421652090 "3"^^ . _:b421653566 "2"^^ . _:b421652269 . . _:b421653649 . _:b421652101 "3"^^ . _:b421653561 "2"^^ . _:b421652268 . _:b421652100 "3"^^ . _:b421653560 "2"^^ . _:b421652271 . _:b421653638 . _:b421652412 . . _:b421652103 "3"^^ . _:b421653563 "2"^^ . _:b421652270 . _:b421652201 . _:b421651646 . _:b421652102 "3"^^ . _:b421653562 "2"^^ . _:b421652265 . . _:b421652097 "3"^^ . _:b421653573 "2"^^ . _:b421652612 . _:b421652264 . . _:b421653572 "2"^^ . _:b421652267 . _:b421652096 "3"^^ . . _:b421652099 "3"^^ . _:b421653575 "2"^^ . _:b421652266 . . _:b6691551 . _:b421652098 "3"^^ . _:b421653574 "2"^^ . _:b421652277 . _:b421652109 "3"^^ . _:b421653569 "2"^^ . _:b421653384 . _:b421652276 . . _:b421652108 "3"^^ . _:b421653568 "2"^^ . _:b421653412 . _:b421652279 . _:b421653017 . _:b421652111 "3"^^ . _:b421653571 "2"^^ . _:b421652278 . . _:b6691578 "a transcriptional module is linked to the mges of hggs" . _:b421652110 "3"^^ . _:b421653570 "2"^^ . _:b421652273 . _:b6691556 . . _:b421652884 . . _:b421652091 . _:b421653581 "2"^^ . _:b421652272 . _:b421652105 "3"^^ . _:b421653324 . _:b6691557 . _:b421652104 "3"^^ . _:b421653580 "2"^^ . _:b421652275 . _:b6691558 . . _:b421652107 "3"^^ . _:b421653583 "2"^^ . _:b421652274 . . _:b6691559 . _:b421653203 . . . _:b421653582 "2"^^ . _:b421653022 . _:b421652285 . _:b421652106 "3"^^ . _:b6691552 . . . _:b421653389 . _:b421652117 "3"^^ . _:b421653577 "2"^^ . _:b421652284 . _:b6691553 . . _:b421652116 "3"^^ . _:b421653576 "2"^^ . _:b421652287 . . _:b6691554 . . _:b421653579 "2"^^ . _:b421652286 . _:b421652119 "3"^^ . . _:b6691555 . _:b421651560 . _:b421651533 . _:b421652118 "3"^^ . _:b421653578 "2"^^ . _:b421653338 . _:b421652281 . _:b6691564 . _:b421653502 . . _:b421653589 "2"^^ . _:b421652280 . _:b421652113 "3"^^ . _:b6691565 . . _:b421652112 "3"^^ . _:b421653588 "2"^^ . _:b421652283 . _:b421652177 . _:b6691566 . _:b421652115 "3"^^ . _:b421653591 "2"^^ . _:b421652282 . . _:b6691567 . _:b421651726 . . . _:b421653590 "2"^^ . _:b421652293 . _:b421652114 "3"^^ . _:b6691560 . . . _:b421652125 "3"^^ . _:b421653585 "2"^^ . _:b421652292 . _:b6691561 . . _:b421653743 . _:b421652124 "3"^^ . _:b421653584 "2"^^ . _:b421652295 . _:b6691562 . _:b421652127 "3"^^ . _:b421653587 "2"^^ . _:b421652294 . _:b6691563 . _:b421652419 . . _:b421653586 "2"^^ . _:b421653116 . _:b421652289 . _:b421652126 "3"^^ . _:b421653765 . _:b6691572 . _:b421652160 . _:b421652121 "3"^^ . _:b421653597 "2"^^ . _:b421652288 . _:b421652926 . _:b6691573 . _:b421653764 . _:b421652120 "3"^^ . _:b421653596 "2"^^ . _:b421652291 . _:b421653282 . _:b421653767 . _:b6691574 . . . _:b421652123 "3"^^ . _:b421653599 "2"^^ . _:b421652290 . . _:b6691575 . _:b421653766 . . _:b421651544 . _:b421653598 "2"^^ . _:b421652301 . _:b421652122 "3"^^ . _:b421653761 . _:b6691568 . _:b421652133 "3"^^ . _:b421653593 "2"^^ . _:b421653269 . _:b421652300 . _:b421653760 . _:b6691569 . . _:b421651980 . _:b421653592 "2"^^ . _:b421652303 . _:b421652132 "3"^^ . _:b421653763 . _:b6691570 . _:b421652135 "3"^^ . _:b421653595 "2"^^ . _:b421652302 . _:b421651682 . _:b6691571 . _:b421653762 . . _:b421653594 "2"^^ . _:b421652297 . _:b421652134 "3"^^ . . _:b6691580 . . _:b421652129 "3"^^ . _:b421653605 "2"^^ . _:b421652296 . _:b6691581 . _:b421652229 . _:b421652128 "3"^^ . _:b421653604 "2"^^ . _:b421652299 . _:b6691582 . _:b421652131 "3"^^ . _:b421653607 "2"^^ . _:b421652298 . . _:b6691583 . _:b421652130 "3"^^ . _:b421653606 "2"^^ . _:b421652309 . . _:b6691576 . _:b421653769 . . . _:b421652141 "3"^^ . _:b421653601 "2"^^ . _:b421652308 . _:b421653768 . _:b6691577 . _:b421652140 "3"^^ . _:b421653600 "2"^^ . _:b421653087 . _:b421652311 . _:b421653771 . _:b6691578 . . . _:b421652143 "3"^^ . _:b421653603 "2"^^ . _:b421652788 . _:b421652310 . _:b421653770 . _:b6691579 . _:b421652142 "3"^^ . _:b421653602 "2"^^ . _:b421652305 . _:b421651916 . . . _:b421652690 . . _:b421652137 "3"^^ . _:b421653613 "2"^^ . _:b421652304 . _:b421651629 . _:b421652436 . _:b421652136 "3"^^ . _:b421653612 "2"^^ . _:b421652307 . _:b421652153 . _:b421652139 "3"^^ . _:b421653615 "2"^^ . _:b421652391 . _:b421652306 . _:b421652256 . . _:b421653614 "2"^^ . _:b421652317 . _:b421652138 "3"^^ . _:b421651742 . _:b421653609 "2"^^ . _:b421652316 . _:b421652149 "3"^^ . . . . _:b421652148 "3"^^ . _:b421653608 "2"^^ . _:b421652319 . . . _:b421653611 "2"^^ . _:b421652318 . _:b421652151 "3"^^ . _:b421652150 "3"^^ . _:b421653610 "2"^^ . _:b421652313 . _:b421652880 . _:b421652145 "3"^^ . _:b421653621 "2"^^ . _:b421652971 . _:b421652312 . _:b421652144 "3"^^ . _:b421653620 "2"^^ . _:b421652315 . . _:b421651638 . . . _:b421652147 "3"^^ . _:b421653623 "2"^^ . _:b421652314 . . . _:b421653622 "2"^^ . _:b421652754 . _:b421652325 . _:b421652146 "3"^^ . "10.1038%2Fnature08712" . . _:b421652157 "3"^^ . _:b421653617 "2"^^ . _:b421652324 . . _:b421653616 "2"^^ . _:b421652327 . _:b421652156 "3"^^ . _:b421653216 . . _:b421652159 "3"^^ . _:b421653619 "2"^^ . _:b421652326 . . . _:b421651612 . _:b421651613 . _:b421652386 . _:b421652013 . _:b421653618 "2"^^ . _:b421652321 . _:b421652158 "3"^^ . _:b421652908 . _:b421653273 . _:b421652153 "3"^^ . _:b421653629 "2"^^ . _:b421652320 . _:b421652152 "3"^^ . _:b421653628 "2"^^ . _:b421652323 . . _:b6691593 "transduced v-myc immortalized mouse NSCs known as C17.226\u201328 as well as primary murine NSCs derived from the mouse telencephalon at embryonic day 13.5 with retroviruses expressing C/EBP\u03B2 and a constitutively active form of Stat3 (Stat3C)>>29<<. ShRNA-mediated silencing targeted C/EBP\u03B2 and Stat3 in the human glioma cell line SNB19 and in serum-free cultures of tumor cells derived from primary GBM that propel the formation of GBM-like tumors after intracranial transplantation in" . _:b421652155 "3"^^ . _:b421653631 "2"^^ . _:b421652322 . . _:b421652154 "3"^^ . _:b421653630 "2"^^ . _:b421652333 . . . _:b421652165 "3"^^ . _:b421653625 "2"^^ . _:b421652332 . _:b6691597 "Finally, we conducted an immunohistochemical analysis for C/EBP\u03B2 and active, phospho-Stat3 in human tumor specimens, and compared their expression with that of YKL40 (a well-established mesenchymal protein expressed in primary human GBM)>>21<<, 32 and with patient outcome in a collection of 62 GBMs (Supplementary Fig. 9)." . _:b421652164 "3"^^ . _:b421653624 "2"^^ . _:b421652335 . _:b421652590 . . _:b421653375 . _:b421652167 "3"^^ . _:b421653627 "2"^^ . _:b421652334 . . . _:b421651713 . . . _:b421653626 "2"^^ . _:b421652329 . _:b421652166 "3"^^ . . _:b421652901 . _:b421653176 . _:b421652161 "3"^^ . _:b421653637 "2"^^ . _:b421652328 . . . _:b421653259 . _:b421652160 "3"^^ . _:b421653636 "2"^^ . _:b421652331 . . _:b421652163 "3"^^ . _:b421653639 "2"^^ . _:b421652330 . . . _:b421652162 "3"^^ . _:b421653638 "2"^^ . _:b421652341 . _:b421652173 "3"^^ . _:b421653633 "2"^^ . _:b421652340 . _:b421652172 "3"^^ . _:b421653632 "2"^^ . _:b421652343 . _:b421652834 . _:b421652175 "3"^^ . _:b421653635 "2"^^ . _:b421652342 . _:b421651692 . _:b421652799 . . . _:b421652978 . . _:b421653634 "2"^^ . _:b421652337 . _:b421652174 "3"^^ . _:b421652169 "3"^^ . _:b421653645 "2"^^ . _:b421652864 . _:b421652336 . . _:b421652168 "3"^^ . _:b421653644 "2"^^ . _:b421652339 . . _:b421652171 "3"^^ . _:b421653647 "2"^^ . _:b421652338 . _:b421652170 "3"^^ . _:b421653646 "2"^^ . _:b421652349 . _:b421651985 . . _:b421652181 "3"^^ . _:b421653641 "2"^^ . _:b421652348 . . _:b421653126 . _:b421652180 "3"^^ . _:b421653640 "2"^^ . _:b421653302 . _:b421652351 . _:b421651686 . . _:b421652887 . _:b421652951 . _:b421652183 "3"^^ . _:b421653643 "2"^^ . _:b421652350 . _:b421653274 . _:b421652182 "3"^^ . _:b421653642 "2"^^ . _:b421652345 . . _:b421652177 "3"^^ . _:b421653653 "2"^^ . _:b421652344 . . _:b421652176 "3"^^ . _:b421653652 "2"^^ . _:b421652347 . . . _:b421653655 "2"^^ . _:b421652346 . _:b421652179 "3"^^ . . _:b421653654 "2"^^ . _:b421652357 . _:b421652178 "3"^^ . . . _:b421652668 . . _:b421653091 . . _:b421653649 "2"^^ . _:b421652356 . _:b421652189 "3"^^ . _:b421652310 . _:b421652099 . _:b421652188 "3"^^ . _:b421653648 "2"^^ . _:b421652359 . _:b421651861 . _:b421651768 . _:b421652191 "3"^^ . _:b421653651 "2"^^ . _:b421652358 . _:b421652190 "3"^^ . _:b421653650 "2"^^ . _:b421652353 . _:b421652185 "3"^^ . _:b421653661 "2"^^ . _:b421652352 . _:b421652184 "3"^^ . _:b421653660 "2"^^ . _:b421652726 . _:b421652355 . . . _:b421652187 "3"^^ . _:b421653663 "2"^^ . _:b421652354 . _:b421652186 "3"^^ . _:b421653662 "2"^^ . _:b421653316 . _:b421652365 . . _:b421653094 . . _:b421653657 "2"^^ . _:b421652364 . _:b421652197 "3"^^ . . _:b421653434 . . _:b421653656 "2"^^ . _:b421652367 . _:b421652196 "3"^^ . _:b421652199 "3"^^ . _:b421653659 "2"^^ . _:b421652366 . . . _:b421652198 "3"^^ . _:b421653658 "2"^^ . _:b421652361 . _:b421653143 . _:b421652193 "3"^^ . _:b421653669 "2"^^ . _:b421652360 . . _:b421652281 . _:b421652192 "3"^^ . _:b421653668 "2"^^ . _:b421653597 . _:b421652363 . _:b421652195 "3"^^ . _:b421653671 "2"^^ . _:b421652362 . _:b6691562 . . _:b421652249 . _:b421652194 "3"^^ . _:b421653670 "2"^^ . _:b421652373 . . _:b421652205 "3"^^ . _:b421653665 "2"^^ . _:b421652372 . _:b421652204 "3"^^ . _:b421653664 "2"^^ . _:b421653480 . _:b421652375 . _:b421652207 "3"^^ . _:b421653667 "2"^^ . _:b421652374 . _:b421653008 . _:b421653449 . _:b421653391 . _:b421652206 "3"^^ . _:b421653666 "2"^^ . _:b421652369 . . _:b421653677 "2"^^ . _:b421652368 . _:b421652201 "3"^^ . _:b421652200 "3"^^ . _:b421653676 "2"^^ . _:b421652371 . _:b421653656 . . _:b421652203 "3"^^ . _:b421653679 "2"^^ . _:b421653514 . _:b421652370 . . _:b421653307 . _:b421652202 "3"^^ . _:b421653678 "2"^^ . _:b421652381 . . _:b421653314 . _:b421652213 "3"^^ . _:b421653673 "2"^^ . _:b421652380 . _:b421651614 . . _:b421652212 "3"^^ . _:b421653672 "2"^^ . _:b421652383 . . _:b421652215 "3"^^ . _:b421653675 "2"^^ . _:b421652382 . . _:b421651683 . _:b421653674 "2"^^ . _:b421652377 . _:b421652214 "3"^^ . . _:b421653065 . _:b421652209 "3"^^ . _:b421653685 "2"^^ . _:b421652376 . _:b421652208 "3"^^ . _:b421653684 "2"^^ . _:b421652379 . . _:b421653687 "2"^^ . _:b421652378 . _:b421652211 "3"^^ . . _:b421652338 . _:b421652210 "3"^^ . _:b421653686 "2"^^ . _:b421652389 . _:b421651649 . _:b421651557 . _:b421653681 "2"^^ . _:b421652388 . _:b421652221 "3"^^ . _:b421652149 . . _:b421651912 . . _:b421652220 "3"^^ . _:b421653680 "2"^^ . _:b421652391 . _:b421652223 "3"^^ . _:b421653683 "2"^^ . _:b421652390 . _:b421652772 . . _:b421652222 "3"^^ . _:b421653682 "2"^^ . _:b421652385 . _:b421651599 . _:b421653693 "2"^^ . _:b421652384 . _:b421652217 "3"^^ . _:b421653642 . _:b421652216 "3"^^ . _:b421653692 "2"^^ . _:b421652387 . _:b421651882 . . . _:b421652219 "3"^^ . _:b421653695 "2"^^ . _:b421653543 . _:b421652386 . _:b421652804 . _:b421652606 . _:b421652174 . _:b421653694 "2"^^ . _:b421652397 . _:b421652218 "3"^^ . _:b421652229 "3"^^ . _:b421653689 "2"^^ . _:b421652396 . . _:b421652802 . . . _:b421652228 "3"^^ . _:b421653688 "2"^^ . _:b421652399 . . _:b421651993 . _:b421652231 "3"^^ . _:b421653691 "2"^^ . _:b421652398 . _:b421652230 "3"^^ . _:b421653690 "2"^^ . _:b421652393 . . _:b421651885 . _:b421653516 . _:b421652060 . _:b421653701 "2"^^ . _:b421652392 . _:b421652225 "3"^^ . _:b421652224 "3"^^ . _:b421653700 "2"^^ . _:b421652395 . _:b421651690 . _:b421652221 . . _:b421652227 "3"^^ . _:b421653703 "2"^^ . _:b421652394 . _:b421653683 . _:b421652910 . _:b6691560 . _:b421652226 "3"^^ . _:b421653702 "2"^^ . _:b421652405 . _:b421652237 "3"^^ . _:b421653697 "2"^^ . _:b421652404 . _:b421652372 . . _:b421651840 . _:b421653696 "2"^^ . _:b421652968 . _:b421652407 . _:b421652236 "3"^^ . _:b421651564 . . . _:b421652239 "3"^^ . _:b421653699 "2"^^ . _:b421652406 . . _:b6691557 "The log-transformation allows convenient linear representation of multiplicative interactions between TF activities>>44<<, 45. TFs were individually added to the model, each time selecting the one contributing the most significant reduction in relative expression error (predicted vs. observed), until error-reduction was no longer significant." . _:b421652527 . _:b421652699 . _:b6691565 . _:b421652238 "3"^^ . _:b421653698 "2"^^ . _:b421652401 . _:b421652233 "3"^^ . _:b421653709 "2"^^ . _:b421652400 . . _:b421652232 "3"^^ . _:b421653708 "2"^^ . _:b421652403 . _:b421652235 "3"^^ . _:b421653711 "2"^^ . _:b421652402 . _:b421652816 . . _:b421652769 . . _:b421653710 "2"^^ . _:b421652413 . _:b421652234 "3"^^ . _:b421651541 . _:b421652370 . _:b421653073 . _:b421652245 "3"^^ . _:b421653705 "2"^^ . _:b421652412 . _:b421653278 . _:b421652244 "3"^^ . _:b421653704 "2"^^ . _:b421652415 . . _:b421652247 "3"^^ . _:b421653707 "2"^^ . _:b421652414 . . _:b421652246 "3"^^ . _:b421653706 "2"^^ . _:b421652409 . _:b421651962 . _:b421652241 "3"^^ . _:b421653717 "2"^^ . _:b421652408 . _:b421653228 . _:b6691574 "methods summary" . . _:b421652240 "3"^^ . _:b421653716 "2"^^ . _:b421652411 . _:b421653725 . _:b421652243 "3"^^ . _:b421653719 "2"^^ . _:b421652410 . . . _:b421652242 "3"^^ . _:b421653718 "2"^^ . _:b421652421 . . _:b421653237 . _:b421652253 "3"^^ . _:b421653713 "2"^^ . _:b421652420 . . . . _:b421652252 "3"^^ . _:b421653712 "2"^^ . _:b421652423 . . _:b421652255 "3"^^ . _:b421653715 "2"^^ . _:b421652422 . _:b421652158 . _:b421653738 . _:b421652254 "3"^^ . _:b421653714 "2"^^ . _:b421652417 . . . _:b421652249 "3"^^ . _:b421653725 "2"^^ . _:b421652416 . _:b421651983 . _:b421653183 . . _:b421652248 "3"^^ . _:b421653724 "2"^^ . _:b421652419 . _:b421651784 . _:b421652359 . _:b421651565 . _:b421653727 "2"^^ . _:b421652418 . _:b421652251 "3"^^ . . _:b421652136 . _:b421652250 "3"^^ . _:b421653726 "2"^^ . _:b421652429 . . . _:b421652261 "3"^^ . _:b421653721 "2"^^ . _:b421652428 . . . _:b421652260 "3"^^ . _:b421653720 "2"^^ . _:b421652431 . _:b421652263 "3"^^ . _:b421653723 "2"^^ . _:b421652430 . _:b421652262 "3"^^ . _:b421653722 "2"^^ . _:b421652425 . _:b421652257 "3"^^ . _:b421653733 "2"^^ . _:b421652424 . . . _:b421652877 . . _:b421653732 "2"^^ . _:b421652427 . _:b421652256 "3"^^ . . _:b421651770 . . _:b421653720 . _:b421653198 . _:b421652259 "3"^^ . _:b421653735 "2"^^ . _:b421652426 . . _:b421652258 "3"^^ . _:b421653734 "2"^^ . _:b421652437 . _:b421652269 "3"^^ . _:b421653729 "2"^^ . _:b421652436 . _:b421652268 "3"^^ . _:b421653728 "2"^^ . _:b421652439 . _:b421653630 . . _:b421653731 "2"^^ . _:b421652438 . _:b421652271 "3"^^ . . . _:b421652270 "3"^^ . _:b421653730 "2"^^ . _:b421653252 . _:b421652433 . . . . _:b421653741 "2"^^ . _:b421652432 . _:b421652265 "3"^^ . _:b421652264 "3"^^ . _:b421653740 "2"^^ . _:b421652435 . _:b421652267 "3"^^ . _:b421653743 "2"^^ . _:b421652434 . . _:b421652266 "3"^^ . _:b421653742 "2"^^ . _:b421652771 . _:b421652445 . _:b421652277 "3"^^ . _:b421653737 "2"^^ . _:b421652444 . _:b421652105 . _:b421652276 "3"^^ . _:b421653736 "2"^^ . _:b421652447 . _:b421651555 . _:b421652279 "3"^^ . _:b421653739 "2"^^ . _:b421652446 . _:b421652278 "3"^^ . _:b421653738 "2"^^ . _:b421652441 . _:b421652273 "3"^^ . _:b421653749 "2"^^ . _:b421652440 . . . _:b421652272 "3"^^ . _:b421653748 "2"^^ . _:b421652443 . _:b421652275 "3"^^ . _:b421653751 "2"^^ . _:b421652848 . _:b421652442 . _:b421652439 . _:b421652274 "3"^^ . _:b421653750 "2"^^ . _:b421652453 . _:b421652571 . _:b421652189 . _:b421651734 . _:b421651756 . _:b421652285 "3"^^ . _:b421653745 "2"^^ . _:b421652452 . _:b421653004 . _:b421652284 "3"^^ . _:b421653744 "2"^^ . _:b421652455 . . _:b421652287 "3"^^ . _:b421653747 "2"^^ . _:b421652454 . . _:b421652286 "3"^^ . _:b421653746 "2"^^ . _:b421652449 . . . _:b421652281 "3"^^ . _:b421653757 "2"^^ . _:b421652448 . _:b421652280 "3"^^ . _:b421653756 "2"^^ . _:b421652451 . . . _:b421652605 . _:b421653719 . _:b421652283 "3"^^ . _:b421653759 "2"^^ . _:b421652450 . . _:b421651941 . _:b421653758 "2"^^ . _:b421652461 . _:b421652282 "3"^^ . _:b421652293 "3"^^ . _:b421653753 "2"^^ . _:b421652460 . . _:b421652292 "3"^^ . _:b421653752 "2"^^ . _:b421652463 . _:b421652952 . _:b421652088 . _:b421652295 "3"^^ . _:b421653755 "2"^^ . _:b421652462 . . _:b421652294 "3"^^ . _:b421653754 "2"^^ . _:b421652457 . _:b421651751 . . _:b421653765 "2"^^ . _:b421652456 . _:b421652289 "3"^^ . _:b421651834 . _:b421652288 "3"^^ . _:b421653764 "2"^^ . _:b421652524 . _:b421652459 . . . _:b421652291 "3"^^ . _:b421653767 "2"^^ . _:b421652458 . _:b421651720 . _:b421653285 . _:b421653029 . _:b421652203 . _:b421652290 "3"^^ . _:b421653766 "2"^^ . _:b421652469 . . _:b421653761 "2"^^ . _:b421652468 . _:b421652301 "3"^^ . . . . _:b421653760 "2"^^ . _:b421652471 . _:b421652300 "3"^^ . . . _:b421652303 "3"^^ . _:b421653763 "2"^^ . _:b421652470 . _:b421652302 "3"^^ . _:b421653762 "2"^^ . _:b421653474 . _:b421652465 . _:b421652344 . _:b421652297 "3"^^ . _:b421652464 . . . . _:b421652467 . _:b421652296 "3"^^ . _:b421651956 . . _:b421652299 "3"^^ . _:b421652466 . _:b421652381 . . . _:b421651986 . _:b421652298 "3"^^ . _:b421652477 . _:b421651605 . . . _:b421652309 "3"^^ . _:b421653769 "2"^^ . _:b421652476 . . _:b421652625 . . _:b421653768 "2"^^ . _:b421652479 . _:b421652308 "3"^^ . _:b421652444 . . _:b421652838 . _:b421652200 . _:b421652311 "3"^^ . _:b421653771 "2"^^ . _:b421653210 . _:b421652478 . _:b421651822 . _:b421652190 . . _:b421652310 "3"^^ . _:b421653770 "2"^^ . _:b421652473 . _:b421651597 . _:b421652472 . _:b421652305 "3"^^ . _:b421652304 "3"^^ . _:b421652475 . _:b421652307 "3"^^ . _:b421652474 . _:b421651973 . _:b421652306 "3"^^ . _:b421651972 . _:b421652317 "3"^^ . _:b421651975 . _:b421652316 "3"^^ . _:b421651558 . _:b421651974 . _:b421652319 "3"^^ . . _:b421652318 "3"^^ . _:b421651969 . . . . _:b421652313 "3"^^ . _:b421651968 . . _:b421651971 . _:b421652312 "3"^^ . . _:b421651970 . _:b421653102 . _:b421652315 "3"^^ . . _:b421652678 . _:b421651981 . _:b421652314 "3"^^ . _:b421651980 . _:b421653728 . _:b421652325 "3"^^ . _:b421651666 . . _:b421652341 . _:b421652324 "3"^^ . _:b421651983 . _:b421651755 . _:b421651982 . _:b421653049 . _:b421652327 "3"^^ . _:b421652022 . _:b421651777 . _:b421651977 . _:b421652326 "3"^^ . _:b421651862 . _:b421651976 . _:b421652813 . _:b421652321 "3"^^ . _:b421653552 . _:b421653680 . _:b421651979 . _:b421652320 "3"^^ . _:b421653149 . _:b421651978 . _:b421653568 . _:b421653207 . _:b421652323 "3"^^ . . . . _:b421652322 "3"^^ . _:b421651989 . . _:b421651988 . _:b421652333 "3"^^ . _:b421651991 . _:b421652332 "3"^^ . _:b421651863 . . _:b421651752 . _:b421651551 . _:b421652247 . _:b421651990 . _:b421652335 "3"^^ . _:b421651985 . _:b421652334 "3"^^ . _:b421652567 . _:b421651984 . _:b421652329 "3"^^ . _:b421652651 . _:b421652642 . _:b421651820 . _:b421652347 . _:b421652328 "3"^^ . _:b421651987 . . . . . _:b421651986 . _:b421652331 "3"^^ . . _:b421651997 . _:b421653142 . _:b421652330 "3"^^ . _:b421652083 . . _:b421651526 . _:b421651996 . _:b421652341 "3"^^ . . . _:b421651999 . _:b421652767 . _:b421652340 "3"^^ . _:b421651998 . _:b421652343 "3"^^ . _:b421653422 . _:b421651993 . _:b421652342 "3"^^ . _:b421652139 . _:b421653128 . _:b421651992 . _:b421652337 "3"^^ . . _:b421651995 . _:b421652336 "3"^^ . _:b421652490 . . _:b421653376 . . _:b421651994 . _:b421653393 . _:b421652339 "3"^^ . . _:b421651553 . . _:b421652572 . _:b421652338 "3"^^ . _:b421652005 . . _:b421652671 . . _:b421652349 "3"^^ . _:b421652004 . _:b421651952 . . _:b421652705 . _:b421652007 . _:b421652348 "3"^^ . _:b421653611 . . _:b421652006 . _:b421652987 . _:b421652351 "3"^^ . _:b421651776 . . _:b421651669 . _:b421652350 "3"^^ . _:b421652001 . _:b421652000 . _:b421652345 "3"^^ . _:b421652003 . _:b421652344 "3"^^ . _:b421652050 . _:b421652002 . _:b421652347 "3"^^ . . _:b421652013 . _:b421652346 "3"^^ . _:b421651741 . . . _:b421652012 . _:b421652357 "3"^^ . _:b421652638 . . _:b421652356 "3"^^ . _:b421652214 . _:b421652015 . _:b421653729 . . _:b421652014 . _:b421653353 . _:b421652359 "3"^^ . _:b421652262 . . _:b421652009 . _:b421652358 "3"^^ . _:b421653322 . _:b421652008 . _:b421652353 "3"^^ . _:b421652011 . _:b421652352 "3"^^ . . . _:b421652010 . _:b421652355 "3"^^ . . . _:b421652354 "3"^^ . _:b421652021 . _:b421652020 . _:b421652365 "3"^^ . _:b421651835 . _:b421652023 . _:b421652364 "3"^^ . _:b421652022 . _:b421652943 . _:b421652367 "3"^^ . . . _:b421652017 . _:b421652366 "3"^^ . . _:b421652016 . _:b421652361 "3"^^ . . _:b421653605 . _:b421652019 . _:b421652360 "3"^^ . . _:b421653212 . _:b421652363 "3"^^ . _:b421652018 . . . _:b421652362 "3"^^ . _:b421652029 . _:b421652028 . _:b421652373 "3"^^ . . . _:b421652372 "3"^^ . _:b421652031 . . . _:b421652030 . _:b421652375 "3"^^ . . . _:b421653477 . _:b421653440 . . _:b421652025 . _:b421653411 . _:b421652374 "3"^^ . . _:b421651875 . _:b421652369 "3"^^ . _:b421652024 . . . _:b421653169 . _:b421652859 . _:b421652027 . _:b421652765 . _:b421652368 "3"^^ . _:b421652849 . _:b421652026 . _:b421652371 "3"^^ . . . _:b421652037 . _:b421652370 "3"^^ . . . _:b421652381 "3"^^ . _:b421652036 . . _:b421652039 . _:b421652380 "3"^^ . . _:b421652383 "2"^^ . _:b421652038 . _:b421652122 . _:b6691561 . _:b421652382 "2"^^ . _:b421652033 . . _:b421653509 . _:b421651848 . _:b421652428 . _:b421652032 . _:b421652377 "3"^^ . . _:b421653508 . _:b421653639 . _:b421652035 . _:b421652376 "3"^^ . _:b421653511 . _:b421652034 . _:b421652664 . _:b421652379 "3"^^ . . _:b421653510 . . _:b421652081 . _:b421652045 . _:b421652378 "3"^^ . . _:b421653505 . _:b421652389 "2"^^ . _:b421652044 . _:b421653340 . _:b421653504 . _:b421652388 "2"^^ . _:b421652047 . _:b421653507 . _:b421652124 . . _:b421652391 "2"^^ . _:b6691591 "validation of the mesenchymal regulatory module" . _:b421652046 . _:b421651585 . . _:b421653506 . _:b421652390 "2"^^ . _:b421653199 . _:b421652041 . . _:b421653517 . _:b421652385 "2"^^ . _:b421652040 . _:b421653516 . _:b421651543 . _:b421653473 . . _:b421652384 "2"^^ . _:b421652043 . _:b421653519 . _:b421652387 "2"^^ . _:b421653727 . _:b421652042 . _:b421653461 . _:b421652289 . _:b421653518 . _:b421652386 "2"^^ . _:b421652053 . _:b421653513 . _:b421652397 "2"^^ . . _:b421652052 . . _:b421653512 . . _:b421652114 . _:b421652396 "2"^^ . _:b421652055 . _:b421653515 . _:b421652399 "2"^^ . _:b421652054 . _:b421653514 . . _:b421652398 "2"^^ . . _:b421652049 . _:b421652925 . _:b421653525 . . _:b421652393 "2"^^ . _:b421653156 . . _:b421652888 . _:b421652048 . _:b421653524 . _:b421652392 "2"^^ . _:b421652051 . . _:b421653527 . _:b421652893 . _:b421652395 "2"^^ . _:b421652050 . _:b421653526 . _:b421652508 . _:b421652394 "2"^^ . _:b421652061 . _:b421653382 . _:b421653521 . _:b421653275 . _:b421652405 "2"^^ . _:b421652060 . _:b421653520 . _:b6691578 _:b6691588 . _:b6691578 _:b6691589 . _:b421652404 "2"^^ . _:b6691578 _:b6691590 . _:b421653064 . _:b421652063 . . . _:b421653523 . _:b6691578 _:b6691584 . _:b6691578 _:b6691585 . _:b421652407 "2"^^ . _:b6691578 _:b6691586 . _:b421652062 . _:b6691578 _:b6691587 . _:b421653522 . . _:b421652406 "2"^^ . . _:b421652057 . _:b421653533 . _:b6691566 "G vectors into human embryonic kidney 293T cells using Fugene 6 (Roche). Lentiviral infections were performed as described>>51<<." . _:b421651819 . _:b421652401 "2"^^ . _:b421652056 . _:b421653532 . _:b421653345 . _:b421652400 "2"^^ . _:b421653342 . _:b421652059 . _:b421653535 . . _:b421652403 "2"^^ . _:b421652058 . _:b421653534 . . _:b421652402 "2"^^ . . _:b421652069 . _:b421653529 . _:b421652413 "2"^^ . _:b421652646 . . _:b421652068 . _:b421653528 . . _:b421653636 . _:b421652412 "2"^^ . . _:b421652071 . . _:b421653531 . _:b421652415 "2"^^ . _:b421652070 . . _:b421653530 . _:b421652414 "2"^^ . _:b421652065 . _:b421653366 . _:b421653541 . _:b421652780 . _:b421652409 "2"^^ . _:b421652064 . _:b421652144 . _:b421653540 . . _:b421652408 "2"^^ . _:b421652067 . _:b421653543 . . . _:b421652411 "2"^^ . _:b421652066 . _:b421653542 . _:b421652410 "2"^^ . _:b421652009 . _:b421652077 . _:b421653537 . _:b421652421 "2"^^ . _:b421652076 . . _:b421653536 . _:b421652420 "2"^^ . _:b421653519 . _:b421652079 . _:b421653539 . . _:b421651727 . _:b421652423 "2"^^ . _:b421652078 . . _:b421653538 . _:b421652645 . . . _:b421652422 "2"^^ . _:b421652073 . _:b421653549 . _:b421653583 . . _:b421652417 "2"^^ . _:b421653012 . _:b421652072 . _:b421653218 . _:b421653691 . _:b421653548 . _:b421652416 "2"^^ . _:b421652075 . _:b421652232 . _:b421653551 . _:b421652419 "2"^^ . _:b421652074 . . _:b421653550 . _:b421652418 "2"^^ . _:b421652085 . _:b421653545 . . _:b421652429 "2"^^ . _:b421652084 . _:b421653361 . _:b421653544 . . . _:b421652428 "2"^^ . _:b421652087 . _:b421653547 . . _:b421652431 "2"^^ . . _:b421652086 . _:b421653546 . _:b421652430 "2"^^ . . _:b421652186 . _:b421652081 . _:b421653557 . . _:b421652425 "2"^^ . _:b421652080 . . _:b421653556 . . _:b421652424 "2"^^ . _:b421652083 . _:b421652030 . _:b421653559 . _:b421653609 . . _:b421652827 . _:b421652427 "2"^^ . _:b421652082 . _:b421653175 . _:b421653558 . . _:b421652426 "2"^^ . _:b421652093 . _:b421653553 . . _:b421652437 "2"^^ . _:b421652092 . _:b421652425 . _:b421653552 . . _:b421652436 "2"^^ . _:b421652095 . _:b421653555 . _:b421652439 "2"^^ . _:b421652094 . _:b421653107 . _:b421653554 . . _:b421652438 "2"^^ . . _:b421652089 . _:b421652473 . _:b421653565 . _:b421652433 "2"^^ . _:b421652088 . _:b421653564 . . _:b421652432 "2"^^ . . _:b421652091 . _:b421653567 . _:b421652435 "2"^^ . _:b421652090 . _:b421653566 . _:b421652434 "2"^^ . _:b421652101 . _:b421652306 . _:b421653561 . _:b421652445 "2"^^ . _:b421652100 . _:b421653053 . _:b421653560 . _:b421652444 "2"^^ . _:b421652103 . _:b421653563 . . _:b6691592 . _:b421652447 "2"^^ . _:b421652102 . _:b421653562 . . _:b421651960 . _:b421652446 "2"^^ . _:b421652097 . _:b421653573 . . . _:b421652441 "2"^^ . . _:b6691586 . _:b421652096 . . _:b421653572 . . _:b421652440 "2"^^ . . _:b421653243 . _:b421652099 . _:b421653575 . . _:b421652443 "2"^^ . _:b421652098 . _:b421652914 . _:b421653574 . . _:b6691592 "We transduced v-myc immortalized mouse NSCs known as C17.>>226<<\u201328 as well as primary murine NSCs derived from the mouse telencephalon at embryonic day 13.5 with retroviruses expressing C/EBP\u03B2 and a constitutively active form of Stat3 (Stat3C)29." . _:b421652442 "2"^^ . . _:b421652109 . . _:b421651662 . _:b421653569 . _:b421652632 . _:b421652152 . _:b421652110 . . _:b421652096 . _:b421652453 "2"^^ . _:b421652108 . _:b421653568 . _:b421652452 "2"^^ . _:b421652111 . _:b421653571 . . . _:b421652455 "2"^^ . _:b421652735 . _:b421652110 . _:b421653522 . _:b421653570 . _:b421653682 . _:b421652454 "2"^^ . _:b421653619 . . _:b421652105 . . _:b421653581 . . _:b421652449 "2"^^ . . _:b421652104 . _:b421652845 . _:b421653580 . _:b421652448 "2"^^ . _:b421652107 . _:b421653583 . _:b421652194 . _:b421652451 "2"^^ . _:b421652106 . _:b421653582 . _:b421651716 . _:b421652450 "2"^^ . . _:b421652117 . _:b421653577 . _:b421652461 "2"^^ . . _:b421652116 . . _:b421653576 . _:b421652215 . _:b421652460 "2"^^ . _:b421652119 . _:b421652497 . _:b421653579 . _:b421652463 "2"^^ . _:b421652118 . _:b421652241 . . _:b421653578 . . _:b421652302 . . _:b421652462 "2"^^ . _:b421652113 . _:b421653589 . _:b421652457 "2"^^ . _:b421652112 . _:b421653588 . _:b421652456 "2"^^ . _:b421652115 . . _:b421653591 . . . _:b421652459 "2"^^ . _:b421652114 . _:b421653590 . . _:b421652458 "2"^^ . _:b421652125 . _:b421653585 . _:b421652469 "2"^^ . _:b421652124 . _:b421653584 . _:b421652684 . . _:b421652468 "2"^^ . _:b421652202 . . _:b421652127 . . _:b421653587 . _:b421652766 . _:b421652108 . _:b421653089 . _:b421652471 "2"^^ . . _:b421652126 . _:b421653586 . _:b421652470 "2"^^ . _:b421652121 . _:b421651593 . _:b421653597 . _:b421652465 "2"^^ . _:b421652120 . _:b421653596 . . _:b421652464 "2"^^ . . _:b421652123 . _:b421653129 . _:b421653599 . _:b421652467 "2"^^ . _:b421652122 . _:b421652745 . _:b421653598 . _:b421653551 . . _:b421652466 "2"^^ . . _:b421652133 . _:b421651639 . _:b421653593 . _:b421653585 . _:b421653360 . . _:b421652477 "2"^^ . _:b421652132 . _:b421653592 . _:b421652476 "2"^^ . _:b421652135 . _:b421653595 . _:b421652479 "2"^^ . _:b421652134 . _:b421653594 . . . _:b421652478 "2"^^ . . . _:b421652345 . _:b421652129 . . _:b421653605 . _:b421652473 "2"^^ . _:b421652821 . _:b421652562 . _:b421652128 . . _:b421653604 . _:b421652550 . . _:b421652472 "2"^^ . . _:b421651894 . _:b421652131 . . _:b421653607 . _:b421652475 "2"^^ . _:b421652130 . _:b421652537 . _:b421653606 . _:b421652474 "2"^^ . _:b421652141 . . _:b421653601 . _:b421653648 . _:b421652140 . _:b421653600 . _:b421652180 . _:b421652143 . _:b421653603 . _:b421652142 . _:b421653602 . . _:b421651817 . _:b421652137 . _:b421653613 . . _:b421652136 . _:b421653612 . . _:b421652139 . _:b421653615 . . _:b421652363 . _:b421652138 . _:b421653614 . _:b421651523 . . _:b421652149 . _:b421653609 . _:b421651754 . _:b421652148 . _:b421652764 . _:b421653608 . _:b421652010 . . _:b421652151 . . _:b421653611 . . _:b421652150 . . _:b421653610 . . _:b6691551 _:b6691560 . _:b6691551 _:b6691561 . _:b6691551 _:b6691562 . _:b421652145 . _:b6691551 _:b6691563 . _:b421653621 . _:b6691551 _:b6691564 . _:b6691551 _:b6691565 . _:b6691551 _:b6691566 . _:b421652144 . . _:b421653620 . _:b6691551 _:b6691552 . _:b6691551 _:b6691553 . _:b421653058 . _:b421652288 . _:b421652187 . . _:b6691551 _:b6691554 . _:b421652147 . _:b6691551 _:b6691555 . _:b421653623 . _:b6691551 _:b6691556 . _:b421652741 . _:b6691551 _:b6691557 . _:b6691551 _:b6691558 . _:b421653119 . _:b421652146 . . _:b6691551 _:b6691559 . _:b421653622 . _:b421652295 . . . _:b421652157 . . _:b421653617 . _:b421652832 . _:b421652156 . _:b421653587 . _:b421653616 . _:b421652159 . _:b421653619 . _:b421652158 . . _:b421653618 . _:b421652312 . _:b421652153 . _:b421653099 . _:b421652226 . _:b421653629 . _:b421653113 . _:b421652152 . _:b421652858 . _:b421653628 . . _:b421652155 . . _:b421653631 . _:b421652154 . _:b421653630 . _:b421653655 . _:b421652165 . _:b421653625 . _:b421651710 . _:b421652164 . _:b421653624 . _:b6691567 _:b6691568 . _:b6691567 _:b6691569 . _:b6691567 _:b6691570 . _:b421652167 . _:b6691567 _:b6691571 . _:b421653627 . _:b6691567 _:b6691572 . . _:b6691567 _:b6691573 . _:b421652166 . _:b421653626 . _:b421652161 . _:b421653637 . _:b421652160 . _:b421653636 . . . _:b421652163 . _:b421653639 . _:b421652162 . . _:b421653638 . . _:b421651804 . _:b421651547 . _:b421652173 . _:b421652879 . _:b421653633 . _:b421653217 . _:b6691574 _:b6691576 . _:b421653564 . _:b6691574 _:b6691577 . _:b421652172 . _:b421653093 . _:b421652944 . _:b421653632 . _:b421652175 . _:b6691574 _:b6691575 . _:b421653635 . _:b421652062 . _:b421652174 . _:b421653634 . . _:b421653095 . _:b421651644 . _:b421652169 . _:b421653645 . . . _:b421652168 . _:b421652403 . _:b421653644 . . _:b421652171 . _:b421653647 . _:b421652170 . . _:b421653646 . . . . _:b421652181 . _:b421652949 . _:b421653641 . . _:b421652904 . _:b421652180 . _:b421653640 . . _:b421652183 . _:b421652595 . _:b421653643 . . _:b421652182 . _:b421653642 . _:b6691578 _:b6691580 . _:b421652906 . _:b6691578 _:b6691581 . _:b6691594 . _:b6691578 _:b6691582 . _:b421652177 . _:b6691578 _:b6691583 . _:b421653653 . _:b421653358 . _:b421652176 . _:b421652623 . _:b6691578 _:b6691579 . _:b421653652 . . . _:b421652179 . _:b421653655 . _:b421652064 . _:b421652178 . _:b421653170 . _:b421653654 . . _:b421652189 . _:b421653649 . . _:b421652188 . _:b421653648 . . _:b421652823 . _:b421652191 . _:b421653651 . . _:b421652190 . _:b421652242 . _:b421653650 . _:b421652185 . . _:b421653661 . . _:b421652184 . _:b421652663 . _:b421653660 . . . _:b421652187 . _:b421653663 . . _:b421652186 . _:b421652768 . _:b421653662 . . . _:b421652197 . . _:b421653657 . . _:b421653737 . _:b421653204 . . _:b421652196 . . _:b421653656 . _:b421653481 . . . _:b421652199 . _:b421651531 . _:b421653659 . . . _:b421653074 . _:b421652198 . _:b421653658 . . _:b421652980 . _:b421652647 . . _:b421651677 . _:b421652193 . _:b421653669 . . . _:b421652192 . _:b421653668 . _:b421652321 . . _:b421652195 . _:b421653671 . _:b421652194 . _:b421653670 . _:b421652397 . _:b421652578 . _:b421652205 . _:b421653665 . . . _:b421652204 . _:b421653664 . _:b421652548 . . _:b421652207 . _:b421653667 . . . . _:b421652206 . _:b421653734 . _:b421653666 . . _:b421653539 . _:b421652201 . . _:b421653677 . . _:b421652200 . _:b421652997 "2"^^ . _:b421653676 . _:b421651579 . _:b421652203 . _:b421652996 "2"^^ . _:b421653679 . _:b421652484 . _:b421652202 . _:b421652999 "2"^^ . . _:b421653678 . _:b421653399 . . . _:b421652213 . _:b421652998 "2"^^ . . _:b421653673 . . _:b421651865 . _:b421652212 . _:b421652993 "2"^^ . . _:b421653672 . _:b421652498 . _:b6691592 . _:b421651853 . _:b421652992 "2"^^ . _:b421652215 . . _:b421653675 . _:b421652279 . _:b421652214 . _:b421652995 "2"^^ . _:b421653674 . . _:b421653485 . . . _:b421652209 . _:b421652994 "2"^^ . _:b421652933 . _:b421653685 . _:b421651870 . _:b421651535 "26"^^ . _:b421651972 . . _:b421653005 "2"^^ . _:b421652208 . _:b421653684 . _:b421651534 "27"^^ . _:b421653004 "2"^^ . _:b421652211 . _:b421653687 . . . _:b421653007 "2"^^ . _:b421652210 . _:b421653686 . . _:b421652803 . . . _:b421653006 "2"^^ . _:b421652221 . . _:b421653681 . _:b421651951 . _:b421652529 . _:b421653042 . _:b421651687 . . _:b421653001 "2"^^ . _:b421652220 . _:b421651532 "32"^^ . _:b421653680 . . _:b421651538 "25"^^ . . _:b421653000 "2"^^ . _:b421652223 . _:b421651539 "24"^^ . _:b421653683 . . _:b421651533 "32"^^ . . . _:b421653003 "2"^^ . _:b421652916 . _:b421652222 . . _:b421653682 . _:b421651523 "85"^^ . _:b421653241 . _:b421651536 "26"^^ . _:b421653420 . . _:b421653002 "2"^^ . _:b421652217 . _:b421653693 . _:b421651537 "25"^^ . _:b421653151 . . _:b421651542 "23"^^ . _:b421653013 "2"^^ . _:b421652216 . _:b421651530 "40"^^ . _:b421653692 . . _:b421651543 "22"^^ . _:b421653318 . . _:b421652219 . _:b421653012 "2"^^ . _:b421653675 . _:b421653695 . . . _:b421651531 "35"^^ . _:b421653015 "2"^^ . _:b421652218 . _:b421651540 "23"^^ . _:b421653694 . . _:b421651528 "42"^^ . _:b421651717 . _:b421653014 "2"^^ . . _:b421651541 "23"^^ . . _:b421651529 "40"^^ . _:b421653689 . . . _:b421653708 . _:b421651716 . _:b421653009 "2"^^ . _:b421652588 . _:b421651527 "43"^^ . _:b421653688 . _:b421651545 "21"^^ . _:b421651719 . _:b421653008 "2"^^ . _:b421653691 . _:b421651544 "21"^^ . _:b421651718 . _:b421653011 "2"^^ . _:b421651547 "20"^^ . _:b421653690 . . . _:b421651713 . _:b421653010 "2"^^ . _:b421651546 "20"^^ . _:b421653701 . . . . _:b421651712 . _:b421653021 "2"^^ . . _:b421651549 "20"^^ . _:b421653700 . _:b421651715 . _:b421653616 . _:b421653020 "2"^^ . _:b421651854 . _:b421651548 "20"^^ . _:b421653703 . . _:b421651714 . _:b421653023 "2"^^ . _:b421651551 "19"^^ . . _:b421653702 . . . _:b421653249 . _:b421651725 . _:b421653022 "2"^^ . _:b421652040 . _:b421651550 "19"^^ . _:b421651526 "51"^^ . _:b421651525 "56"^^ . _:b421653697 . _:b421652909 . . _:b421651524 "61"^^ . _:b421651553 "18"^^ . _:b421651724 . _:b421653017 "2"^^ . _:b421651845 . _:b421653696 . _:b421653349 . _:b421651727 . _:b421653016 "2"^^ . _:b421651552 "19"^^ . . _:b421653699 . _:b421652175 . _:b421651849 . _:b421651726 . _:b421653019 "2"^^ . _:b421652501 . . . _:b421653479 . _:b421653698 . . _:b421651554 "18"^^ . _:b421653138 . _:b421651721 . _:b421653018 "2"^^ . _:b421651847 . _:b421651555 "16"^^ . _:b421653709 . _:b421652878 . . _:b421651720 . _:b421653029 "2"^^ . _:b421651556 "16"^^ . _:b421653708 . . _:b421651696 . _:b421653031 . _:b421651723 . _:b421653028 "2"^^ . _:b421651557 "16"^^ . _:b421653711 . _:b421651722 . _:b421653031 "2"^^ . _:b421651554 . _:b421651558 "16"^^ . _:b421653710 . . _:b421651733 . _:b421653444 . _:b421653030 "2"^^ . _:b421651559 "16"^^ . _:b421653705 . . . . . _:b421651732 . _:b421653025 "2"^^ . _:b421651552 . _:b421651560 "15"^^ . _:b421651522 "120"^^ . _:b421653704 . _:b421651567 "13"^^ . _:b421651735 . _:b421653024 "2"^^ . _:b421651561 "15"^^ . _:b421653651 . _:b421653707 . _:b421651566 "13"^^ . . _:b421653770 . _:b421651734 . _:b421653027 "2"^^ . _:b421651562 "15"^^ . . _:b421653706 . _:b421651729 . _:b421653026 "2"^^ . _:b421651563 "15"^^ . . _:b421653717 . _:b421652517 . _:b421651564 "14"^^ . _:b421653463 . _:b421652895 . _:b421652090 . _:b421651728 . _:b421653037 "2"^^ . _:b421653716 . _:b421651565 "14"^^ . _:b421651731 . _:b421653036 "2"^^ . _:b421651763 . _:b421653719 . _:b421653700 . _:b421651730 . _:b421653039 "2"^^ . _:b421652580 . _:b421653718 . _:b421652395 . _:b421651741 . _:b421653038 "2"^^ . _:b421652348 . _:b421653713 . . _:b421651740 . _:b421653033 "2"^^ . _:b421652135 . . _:b421653712 . _:b421653406 . _:b421651575 "13"^^ . _:b421651743 . _:b421653032 "2"^^ . _:b421653715 . _:b421651574 "13"^^ . _:b421651742 . _:b421653035 "2"^^ . _:b421653714 . . _:b421651573 "13"^^ . . _:b421651737 . _:b421653034 "2"^^ . _:b421651617 . _:b421653725 . _:b421651572 "13"^^ . . _:b421651736 . _:b421653045 "2"^^ . . _:b421653724 . . . . _:b421651571 "13"^^ . _:b421651739 . _:b421653044 "2"^^ . . _:b421653727 . _:b421651570 "13"^^ . . _:b421651738 . _:b421653325 . _:b421653047 "2"^^ . _:b421653726 . _:b421651569 "13"^^ . _:b421651762 . . _:b421651749 . _:b421653046 "2"^^ . _:b421653721 . _:b421651568 "13"^^ . _:b421651748 . _:b421653041 "2"^^ . . _:b421651583 "12"^^ . _:b421653720 . _:b421651751 . _:b421653040 "2"^^ . _:b421651582 "12"^^ . _:b421653723 . _:b421651750 . _:b421653043 "2"^^ . . _:b421651809 . _:b421653722 . _:b421653214 . . _:b421651581 "12"^^ . _:b421651745 . _:b421653042 "2"^^ . _:b421651580 "12"^^ . _:b421653733 . _:b421651744 . _:b421653053 "2"^^ . _:b421651579 "12"^^ . _:b421653732 . . _:b421651747 . _:b421653052 "2"^^ . _:b421651578 "12"^^ . _:b421653735 . . _:b421651746 . _:b421653055 "2"^^ . . _:b421653734 . . _:b421651577 "13"^^ . _:b421652196 . _:b421652679 . _:b421651757 . _:b421653454 . _:b421653054 "2"^^ . . _:b421653729 . _:b421651576 "13"^^ . _:b421651756 . _:b421653049 "2"^^ . _:b421651591 "11"^^ . _:b421653728 . _:b421652839 . _:b421653561 . _:b421651759 . _:b421653048 "2"^^ . _:b421651590 "11"^^ . _:b421653731 . _:b421651758 . _:b421653051 "2"^^ . 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_:b421651784 . _:b421653093 "2"^^ . _:b421653260 . _:b421651618 "9"^^ . _:b421653453 . _:b6691596 _:b6691597 . . _:b421651787 . _:b421653092 "2"^^ . _:b6691596 _:b6691598 . _:b421653263 . _:b421651619 "9"^^ . _:b421651786 . _:b421653095 "2"^^ . _:b421653262 . _:b421651616 "9"^^ . _:b421651797 . _:b421653094 "2"^^ . _:b421652641 . _:b421652292 . _:b421653257 . _:b421651617 "9"^^ . _:b421652882 . _:b421651796 . _:b421653089 "2"^^ . _:b421652045 . . . _:b421651630 "8"^^ . _:b421653256 . _:b421651799 . _:b421653088 "2"^^ . _:b421651914 . _:b421653259 . . _:b421651631 "8"^^ . _:b421651798 . _:b421653091 "2"^^ . _:b421652375 . . _:b421653258 . . _:b421651628 "9"^^ . _:b6691591 _:b6691592 . . _:b6691591 _:b6691593 . _:b421651793 . _:b421653090 "2"^^ . _:b6691591 _:b6691594 . _:b6691591 _:b6691595 . _:b421653269 . _:b421651629 "9"^^ . _:b421652609 . . _:b421651792 . _:b421653101 "2"^^ . _:b421653268 . _:b421651626 "9"^^ . . _:b421652957 . _:b421651795 . _:b421653100 "2"^^ . . _:b421653496 . _:b421653271 . _:b421651627 "9"^^ . . . . _:b421651794 . _:b421653103 "2"^^ . . _:b421653270 . _:b421651624 "9"^^ . _:b421651805 . _:b421653102 "2"^^ . . _:b421653265 . _:b421651625 "9"^^ . . _:b421653097 "2"^^ . _:b421651804 . _:b421651638 "8"^^ . _:b421653264 . _:b421652526 . _:b421651807 . _:b421653238 . _:b421653096 "2"^^ . _:b421651639 "8"^^ . _:b421653267 . . _:b421651806 . _:b421653099 "2"^^ . . _:b421653266 . _:b421653085 . _:b421651636 "8"^^ . _:b421651801 . _:b421653098 "2"^^ . _:b421652954 . _:b421651637 "8"^^ . _:b421653277 . _:b421651800 . _:b421653109 "2"^^ . _:b421651634 "8"^^ . _:b421653276 . . _:b421651803 . _:b421653108 "2"^^ . _:b421651635 "8"^^ . _:b421653279 . _:b421652615 . . . _:b421652066 . _:b421651802 . _:b421653111 "2"^^ . . _:b421651632 "8"^^ . _:b421653278 . _:b421651813 . _:b421653110 "2"^^ . _:b421651633 "8"^^ . _:b421653273 . _:b421653433 . _:b421651954 . _:b421651812 . _:b421653105 "2"^^ . _:b421651646 "8"^^ . _:b421653272 . . _:b421652272 . _:b421651815 . _:b421653104 "2"^^ . _:b421651647 "8"^^ . _:b421653275 . _:b421651814 . _:b421653374 . _:b421653107 "2"^^ . _:b421651644 "8"^^ . _:b421653274 . _:b421651809 . _:b421653106 "2"^^ . _:b421651645 "8"^^ . _:b421653285 . _:b6691571 . _:b421651808 . _:b421653117 "2"^^ . . _:b421653284 . _:b421651642 "8"^^ . _:b421651811 . _:b421653116 "2"^^ . _:b421651643 "8"^^ . _:b421653287 . . _:b421652667 . _:b421652833 . _:b421651810 . _:b421653119 "2"^^ . _:b421651640 "8"^^ . _:b421653286 . . _:b421651821 . _:b6691598 . _:b421653118 "2"^^ . . _:b421653281 . . _:b421651641 "8"^^ . _:b421651820 . _:b421653113 "2"^^ . _:b421651654 "7"^^ . _:b421653280 . _:b421652731 . _:b421651774 . _:b421651823 . _:b421653112 "2"^^ . _:b421651655 "7"^^ . _:b421653283 . _:b421652729 . _:b421652592 . _:b421653633 . _:b421651822 . _:b421653115 "2"^^ . _:b421651652 "7"^^ . . _:b421653282 . _:b421651817 . _:b421653114 "2"^^ . _:b421651653 "7"^^ . _:b421652737 . _:b421653293 . _:b421652240 . _:b6691571 . _:b421651816 . _:b421653125 "2"^^ . _:b421651650 "7"^^ . . _:b421653292 . _:b421651819 . _:b421653124 "2"^^ . _:b421651651 "7"^^ . . _:b421653295 . _:b421653334 . . . _:b6691569 "Other methods, including differential expression analysis, DNA-binding-site enrichment analysis>>8<< and relevance network analysis34 could not identify C/EBP\u03B2 and Stat3 as MRs (see Supplementary Note 2)." . _:b421652082 . _:b421651818 . _:b421653127 "2"^^ . _:b421651648 "8"^^ . _:b421653294 . _:b421651829 . _:b421653126 "2"^^ . _:b421651649 "8"^^ . _:b421653289 . . _:b421651828 . _:b421653121 "2"^^ . _:b421651662 "7"^^ . . _:b421653288 . _:b421652970 . . . _:b421651704 . _:b421653120 "2"^^ . _:b421651663 "7"^^ . _:b421651831 . _:b421653291 . _:b421651830 . _:b421653123 "2"^^ . _:b421651660 "7"^^ . _:b421653290 . . _:b421651825 . _:b421653122 "2"^^ . _:b421651661 "7"^^ . _:b421653301 . _:b421651824 . _:b421653133 "2"^^ . _:b421651658 "7"^^ . . _:b421653300 . . _:b421651827 . _:b421653132 "2"^^ . _:b421651659 "7"^^ . . _:b421653303 . _:b421651826 . _:b421653135 "2"^^ . _:b421651890 . _:b421651656 "7"^^ . _:b421653302 . . _:b421651837 . _:b421653134 "2"^^ . _:b421651657 "7"^^ . _:b421653297 . . _:b421651836 . _:b421653129 "2"^^ . _:b421651670 "7"^^ . _:b421653296 . _:b421653161 . _:b421651839 . _:b421653128 "2"^^ . _:b421651671 "7"^^ . . _:b421653299 . . _:b421651838 . _:b421653131 "2"^^ . _:b421651668 "7"^^ . _:b421653298 . _:b421653326 . _:b421651833 . _:b421653439 . _:b421653130 "2"^^ . _:b421651669 "7"^^ . . _:b421653309 . _:b421652787 . _:b421651832 . _:b421653141 "2"^^ . _:b421651666 "7"^^ . _:b421652049 . _:b421653308 . _:b421651835 . _:b421653140 "2"^^ . . _:b421651667 "7"^^ . _:b421653311 . _:b421652512 . _:b421651834 . _:b421653143 "2"^^ . _:b421651664 "7"^^ . _:b421653310 . _:b421651845 . _:b421653142 "2"^^ . _:b421652682 . _:b421651665 "7"^^ . . _:b421653305 . . _:b421651844 . _:b421653137 "2"^^ . _:b421651678 "7"^^ . _:b421653304 . _:b421651592 . _:b421651847 . _:b421653136 "2"^^ . _:b421651679 "7"^^ . . _:b421652545 . _:b421653307 . . _:b421651846 . _:b6691583 "ARACNe is an information theoretic approach for the inference of TF-target interactions from large sets of gene expression profiles>>9<<, 16, further refined to infer directed (i.e. causal) interactions12, 22 (see Methods)." . _:b421653139 "2"^^ . _:b421651676 "7"^^ . . _:b421653306 . _:b421651841 . _:b421653138 "2"^^ . . _:b421651677 "7"^^ . . _:b421653317 . _:b421652188 . _:b421651840 . _:b421653149 "2"^^ . . _:b421651674 "7"^^ . _:b421653316 . . _:b421651843 . _:b421653148 "2"^^ . _:b421651675 "7"^^ . _:b421653319 . . _:b421651842 . _:b421653151 "2"^^ . _:b421651672 "7"^^ . _:b421653318 . . _:b421653577 . _:b421652166 . _:b421651853 . _:b421653150 "2"^^ . _:b421652942 . _:b421652071 . _:b421651678 . _:b421651673 "7"^^ . _:b421653313 . . _:b421651686 "6"^^ . _:b421652886 . _:b421651852 . _:b421653145 "2"^^ . _:b421653312 . _:b421651687 "6"^^ . _:b421652407 . _:b421651825 . . _:b421653144 "2"^^ . _:b421651855 . _:b421653315 . . _:b421651854 . _:b421653147 "2"^^ . _:b421653041 . . _:b421651684 "7"^^ . _:b421652509 . _:b421653314 . _:b421652890 . _:b421651849 . _:b421653146 "2"^^ . _:b421652774 . _:b421651685 "7"^^ . _:b421653325 . . _:b421651848 . _:b421653157 "2"^^ . _:b421651682 "7"^^ . . _:b421653324 . _:b421651851 . _:b421653156 "2"^^ . . _:b421651683 "7"^^ . . _:b421653327 . _:b421651850 . _:b421653159 "2"^^ . _:b421651680 "7"^^ . . _:b421653326 . _:b421651861 . _:b421653158 "2"^^ . _:b421651681 "7"^^ . _:b421653321 . _:b421651694 "6"^^ . _:b421651860 . _:b421653153 "2"^^ . . _:b421653320 . . _:b421653197 . _:b421651695 "6"^^ . _:b421651863 . _:b421653152 "2"^^ . . _:b421653323 . _:b421651692 "6"^^ . . _:b421651862 . _:b421653155 "2"^^ . _:b421653322 . _:b421651668 . _:b421651693 "6"^^ . _:b421651857 . _:b421653305 . _:b421653154 "2"^^ . . _:b421653333 . . . . _:b421651690 "6"^^ . . _:b421651856 . _:b421653165 "2"^^ . _:b421651771 . _:b421653332 . _:b421651691 "6"^^ . . _:b421653164 "2"^^ . _:b421651859 . . _:b421653335 . _:b421651688 "6"^^ . _:b421651858 . _:b421653167 "2"^^ . _:b421653334 . _:b421651689 "6"^^ . _:b421651869 . _:b421653166 "2"^^ . _:b421653329 . _:b421651702 "6"^^ . _:b421651868 . _:b421653161 "2"^^ . _:b421653328 . . _:b421651703 "6"^^ . _:b421651871 . _:b421653694 . _:b421653160 "2"^^ . . _:b421653331 . _:b421652962 . _:b421651700 "6"^^ . _:b421651870 . _:b421653163 "2"^^ . . _:b421653330 . _:b421651701 "6"^^ . _:b421651865 . _:b421653162 "2"^^ . _:b421652542 . _:b421653341 . . _:b421652965 . _:b421652079 . _:b421651698 "6"^^ . . . _:b421651864 . _:b421653173 "2"^^ . _:b421653340 . _:b421651699 "6"^^ . _:b421653604 . _:b421651867 . _:b421653172 "2"^^ . . _:b421653343 . _:b421652007 . _:b421651696 "6"^^ . _:b421653509 . _:b421651866 . _:b421653175 "2"^^ . . _:b421653342 . _:b421652411 . _:b421651697 "6"^^ . _:b421651877 . _:b421653174 "2"^^ . . _:b421653337 . _:b421651710 "6"^^ . _:b421651876 . _:b421653309 . _:b421653169 "2"^^ . _:b421653201 . _:b421653336 . _:b421651711 "6"^^ . _:b421653550 . _:b421651879 . _:b421653168 "2"^^ . . _:b421652675 . _:b421653339 . _:b421651708 "6"^^ . _:b421651878 . _:b421653171 "2"^^ . _:b421653338 . . _:b421651709 "6"^^ . _:b421651873 . _:b421653170 "2"^^ . . _:b421653349 . _:b6691572 . _:b421652561 . _:b421651706 "6"^^ . _:b421651872 . _:b421653181 "2"^^ . _:b421653348 . . _:b421651707 "6"^^ . . _:b421653180 "2"^^ . _:b421652701 . _:b421651875 . _:b421653351 . _:b421651704 "6"^^ . _:b421652881 . _:b421651874 . _:b421653183 "2"^^ . _:b421653350 . . _:b421651705 "6"^^ . _:b421651885 . _:b421653182 "2"^^ . _:b421652140 . . . _:b421653345 . _:b421651718 "6"^^ . _:b421652358 . _:b421651884 . _:b421653177 "2"^^ . _:b421653344 . _:b421651719 "6"^^ . . _:b421653176 "2"^^ . _:b421651887 . _:b421653347 . _:b6691576 "GBM transcriptional network was generated by ARACNe>>12<<. Total RNA was reverse transcribed to complementary DNA and amplified using primers specific for human and murine transcripts." . _:b421651716 "6"^^ . . . _:b421651886 . _:b421653179 "2"^^ . _:b421653346 . . _:b421651717 "6"^^ . _:b421651881 . _:b421653178 "2"^^ . _:b421653357 . _:b421651714 "6"^^ . . . _:b421651880 . _:b421653189 "2"^^ . _:b421652137 . _:b421653356 . . _:b421651715 "6"^^ . _:b421651883 . _:b421653188 "2"^^ . . _:b421653359 . _:b421653253 . _:b421651712 "6"^^ . _:b421651882 . _:b421653191 "2"^^ . _:b421653358 . . _:b421651713 "6"^^ . _:b421651893 . _:b421653190 "2"^^ . . _:b421653353 . _:b421651726 "6"^^ . _:b6691597 . _:b421652264 . _:b421651892 . _:b421653185 "2"^^ . . _:b421653352 . _:b421652026 . _:b421651727 "6"^^ . _:b421651810 . _:b421651895 . _:b421653184 "2"^^ . _:b421653355 . . _:b421651724 "6"^^ . _:b421651894 . _:b421653187 "2"^^ . _:b421653354 . _:b421651725 "6"^^ . _:b421651889 . _:b421653186 "2"^^ . _:b421653365 . _:b421651722 "6"^^ . _:b421651888 . _:b421653742 . _:b421653197 "2"^^ . _:b421653364 . _:b421651723 "6"^^ . _:b421651891 . _:b421653196 "2"^^ . _:b421651548 . _:b421653367 . . _:b421651720 "6"^^ . _:b421651890 . _:b421653232 . _:b421653199 "2"^^ . . _:b421653366 . . _:b421651721 "6"^^ . _:b421651675 . _:b421651901 . _:b421653198 "2"^^ . _:b421653361 . _:b421652786 . _:b421651734 "6"^^ . _:b421651900 . _:b421653193 "2"^^ . _:b421653360 . _:b421651735 "6"^^ . _:b421651994 . _:b421651903 . _:b421653192 "2"^^ . _:b421652278 . _:b421653363 . _:b421651749 . _:b421652116 . _:b421651732 "6"^^ . . _:b421651902 . _:b421653383 . _:b421653195 "2"^^ . _:b421653362 . _:b421651733 "6"^^ . _:b421653356 . _:b421651897 . _:b421653194 "2"^^ . _:b421651802 . . _:b421653373 . _:b421651730 "6"^^ . _:b421651896 . _:b421653397 . _:b421653205 "2"^^ . _:b421653372 . . _:b421651731 "6"^^ . _:b421651899 . _:b421653204 "2"^^ . _:b421653375 . _:b421651728 "6"^^ . _:b6691584 . _:b421651898 . _:b421653207 "2"^^ . . _:b421653374 . _:b421651729 "6"^^ . _:b421651909 . _:b421653206 "2"^^ . . _:b421653369 . . _:b421651562 . _:b421651742 "6"^^ . _:b421651908 . _:b421653201 "2"^^ . . _:b421653368 . _:b421652693 . . _:b421651743 "6"^^ . _:b421651911 . _:b421653200 "2"^^ . . _:b421653371 . . . _:b421651740 "6"^^ . _:b421651910 . _:b421653203 "2"^^ . _:b421651944 . _:b421653370 . . _:b421651741 "6"^^ . _:b421651905 . _:b421653202 "2"^^ . _:b421653381 . _:b421651738 "6"^^ . _:b421651904 . _:b421653213 "2"^^ . _:b421653380 . _:b421653436 . _:b421652297 . _:b421651739 "6"^^ . _:b421651907 . _:b421653212 "2"^^ . . . _:b421653383 . _:b421652719 . _:b421652715 . _:b421653421 . _:b421651736 "6"^^ . _:b421651906 . _:b421653215 "2"^^ . _:b421653382 . _:b421652078 . _:b421651737 "6"^^ . _:b421651745 . _:b421651917 . _:b421653214 "2"^^ . _:b421653377 . . _:b421651916 . _:b421653209 "2"^^ . _:b421653376 . _:b421651749 "5"^^ . _:b421651919 . _:b421653208 "2"^^ . _:b421653379 . _:b421651748 "5"^^ . _:b421653150 . _:b421652353 . _:b421651918 . _:b421653733 . _:b421653211 "2"^^ . _:b421653378 . _:b421651751 "5"^^ . _:b421651913 . _:b421653210 "2"^^ . _:b421653389 . . _:b421651729 . _:b421651750 "5"^^ . _:b421651912 . _:b421653221 "2"^^ . _:b421653388 . _:b421651915 . _:b421653220 "2"^^ . _:b421653391 . _:b421651744 "6"^^ . _:b421652465 . _:b421651914 . _:b421653223 "2"^^ . _:b421652829 . _:b421653390 . _:b421651747 "5"^^ . _:b421651745 "6"^^ . _:b421651925 . _:b421653222 "2"^^ . . . _:b421653385 . . _:b421651746 "5"^^ . . _:b421651924 . _:b421653217 "2"^^ . . _:b421653384 . . _:b421651757 "5"^^ . _:b421652300 . _:b421651927 . _:b421653216 "2"^^ . . _:b421653387 . _:b421651756 "5"^^ . _:b421653494 . _:b421652581 . _:b421651926 . _:b421653219 "2"^^ . _:b421653045 . _:b421653386 . _:b421651759 "5"^^ . . _:b421653218 "2"^^ . _:b421651921 . _:b421653397 . _:b421651758 "5"^^ . _:b421651920 . _:b421653229 "2"^^ . _:b421653396 . . _:b421652836 . _:b421652369 . _:b421651753 "5"^^ . . _:b421651923 . _:b421653228 "2"^^ . _:b421653399 . _:b421651752 "5"^^ . _:b421651922 . _:b421653231 "2"^^ . _:b421653398 . _:b421651755 "5"^^ . _:b421652630 . . . . _:b421651933 . _:b421653230 "2"^^ . _:b421653393 . _:b421651754 "5"^^ . _:b421652594 . _:b421651932 . _:b421653225 "2"^^ . . _:b421653392 . _:b421651765 "5"^^ . _:b421651935 . _:b421653224 "2"^^ . _:b421652599 . _:b421653395 . _:b421651764 "5"^^ . _:b421651753 . _:b421652268 . _:b421651934 . _:b421653227 "2"^^ . _:b421653394 . _:b421651767 "5"^^ . _:b421651893 . _:b421653220 . _:b421651929 . _:b421653226 "2"^^ . _:b421651589 . . . . _:b421652442 . _:b421653405 . _:b421651766 "5"^^ . _:b421653599 . _:b421652669 . _:b421651928 . _:b421653237 "2"^^ . _:b421653404 . _:b421651761 "5"^^ . _:b421651931 . _:b421653236 "2"^^ . _:b421653407 . _:b421653751 . _:b421651760 "5"^^ . _:b421652103 . _:b421651930 . _:b421653239 "2"^^ . . _:b421653406 . _:b421653257 . _:b421651763 "5"^^ . _:b421651941 . _:b421653238 "2"^^ . _:b421653144 . _:b421653401 . _:b421651762 "5"^^ . _:b421653670 . . _:b421652336 . _:b421651940 . _:b421653233 "2"^^ . . _:b421653400 . _:b421651773 "5"^^ . _:b421651943 . _:b421653232 "2"^^ . _:b421653403 . _:b421651772 "5"^^ . . _:b421651942 . _:b421653235 "2"^^ . _:b421653402 . _:b421651775 "5"^^ . . _:b421651937 . _:b421653234 "2"^^ . _:b421653413 . _:b421651774 "5"^^ . _:b421651936 . _:b421653245 "2"^^ . _:b421653412 . . _:b421652307 . _:b421651769 "5"^^ . . _:b421651932 . _:b421653244 "2"^^ . _:b421651939 . . . _:b421653415 . _:b421651768 "5"^^ . _:b421651938 . _:b421653247 "2"^^ . _:b421653414 . _:b421651771 "5"^^ . _:b421651949 . _:b421653246 "2"^^ . . _:b421653409 . _:b421652389 . _:b421651770 "5"^^ . _:b421651948 . _:b421653241 "2"^^ . _:b421652659 . _:b421653408 . _:b421651898 . _:b421652871 . _:b421651781 "5"^^ . _:b421651951 . _:b421653706 . _:b421653404 . _:b421653240 "2"^^ . . _:b421653411 . _:b421652418 . _:b421651780 "5"^^ . _:b421651950 . _:b421653243 "2"^^ . _:b421653410 . _:b421651783 "5"^^ . _:b421651920 . _:b421651801 . _:b421651945 . _:b421653242 "2"^^ . . _:b421653421 . _:b421651782 "5"^^ . . _:b421651944 . _:b421653253 "2"^^ . _:b421653420 . _:b421651777 "5"^^ . _:b421651947 . _:b421653252 "2"^^ . _:b421653423 . _:b421651776 "5"^^ . . . _:b421651946 . _:b421653255 "2"^^ . _:b421653422 . _:b421651779 "5"^^ . _:b421651957 . _:b421653254 "2"^^ . _:b421653417 . _:b421651778 "5"^^ . . . _:b421653249 "2"^^ . _:b421651956 . . _:b421653416 . _:b421651789 "5"^^ . . _:b421653618 . _:b421651959 . _:b421653248 "2"^^ . _:b421652927 . . _:b6691586 "ARACNe is an information theoretic approach for the inference of TF-target interactions from large sets of gene expression profiles9, 16, further refined to infer directed (i.e. causal) interactions12, >>22<< (see Methods)." . _:b421653419 . _:b421652800 . _:b421651788 "5"^^ . _:b421651958 . _:b421653251 "2"^^ . . _:b421653418 . _:b421652570 . _:b421651791 "5"^^ . _:b421652760 . _:b421651953 . _:b421653250 "2"^^ . _:b421652462 . _:b421651536 . _:b421653429 . _:b421651790 "5"^^ . . _:b421651952 . _:b421653261 "2"^^ . . . _:b421653428 . _:b421651785 "5"^^ . _:b421651955 . _:b421653260 "2"^^ . _:b421652837 . _:b421653365 . _:b421653431 . . _:b421651784 "5"^^ . _:b421653001 . _:b421651954 . _:b421653263 "2"^^ . _:b421653430 . _:b421651787 "5"^^ . _:b421651965 . _:b421653262 "2"^^ . . _:b421653425 . _:b421651786 "5"^^ . _:b421652597 . . _:b421651964 . _:b421653489 . _:b421653257 "2"^^ . . _:b421653424 . _:b421651797 "5"^^ . _:b421653470 . _:b421651664 . . _:b421651967 . _:b421653256 "2"^^ . _:b421653427 . _:b421651796 "5"^^ . _:b421651966 . _:b421653259 "2"^^ . . _:b421653426 . _:b421652134 . _:b421651799 "5"^^ . _:b421651737 . _:b421651961 . _:b421653258 "2"^^ . _:b421653437 . _:b421651798 "5"^^ . . _:b421653269 "2"^^ . _:b421651960 . _:b421653436 . _:b421651793 "5"^^ . _:b421653478 . _:b421651733 . . _:b421651963 . _:b421653268 "2"^^ . . . _:b421653323 . _:b421653439 . _:b421651792 "5"^^ . _:b421653574 . . _:b421653271 "2"^^ . . _:b421651962 . _:b421653438 . _:b421651795 "5"^^ . . _:b421652709 . _:b421652489 . _:b421653270 "2"^^ . _:b421653433 . _:b421651794 "5"^^ . . _:b421653223 . _:b421652100 . _:b421653265 "2"^^ . _:b421653432 . _:b421651805 "5"^^ . _:b421653264 "2"^^ . _:b421653435 . _:b421651804 "5"^^ . _:b421653267 "2"^^ . . _:b421653434 . _:b421651807 "5"^^ . _:b421653266 "2"^^ . _:b421652686 . _:b421653445 . _:b421651806 "5"^^ . . . _:b421653277 "2"^^ . _:b421653444 . _:b421651801 "5"^^ . _:b421653276 "2"^^ . _:b421653447 . . _:b421651800 "5"^^ . _:b421653279 "2"^^ . _:b421653446 . _:b421651803 "5"^^ . _:b421653278 "2"^^ . _:b421653441 . _:b421651802 "5"^^ . _:b421652619 . . _:b421653273 "2"^^ . . _:b421651778 . . _:b421653440 . _:b421651813 "5"^^ . . . _:b421653272 "2"^^ . _:b421653443 . _:b421651812 "5"^^ . _:b421652984 . _:b421652985 . . _:b421652986 . _:b421653606 . _:b421653512 . _:b421653275 "2"^^ . _:b421651966 . _:b421652987 . _:b421653442 . . _:b421651815 "5"^^ . _:b421653172 . _:b421652988 . _:b421652989 . _:b421652990 . _:b421653274 "2"^^ . . _:b421653453 . _:b421652991 . _:b421651814 "5"^^ . _:b421652459 . _:b421652976 . _:b421652977 . _:b421652978 . _:b421653285 "2"^^ . _:b421652979 . _:b421653452 . _:b421651809 "5"^^ . _:b421652980 . . _:b421652981 . . _:b421653284 "2"^^ . _:b421652982 . _:b421652983 . _:b421653455 . _:b421651808 "5"^^ . _:b421652968 . _:b421652969 . _:b421652970 . _:b421653287 "2"^^ . _:b421653185 . _:b421652959 . _:b421652971 . _:b421653454 . _:b421652211 . _:b421651811 "5"^^ . _:b421652972 . _:b421652973 . _:b421652974 . _:b421653286 "2"^^ . _:b421652975 . _:b421653449 . . _:b421651810 "5"^^ . _:b421651616 . _:b421652960 . _:b421652961 . _:b421652962 . _:b421653281 "2"^^ . _:b421651821 "4"^^ . _:b421653448 . _:b421652963 . _:b421652964 . . . _:b421652965 . _:b421652966 . _:b421653280 "2"^^ . _:b421651820 "4"^^ . _:b421653451 . _:b421652967 . _:b421652952 . _:b421652953 . . _:b421652954 . _:b421653283 "2"^^ . _:b421651823 "4"^^ . _:b421653450 . _:b421652955 . _:b421652956 . _:b421652957 . _:b421651654 . _:b421653282 "2"^^ . _:b421652958 . _:b421651822 "4"^^ . _:b421653461 . _:b421652959 . . _:b421653442 . _:b421652944 . _:b421652945 . _:b421652946 . _:b421653293 "2"^^ . _:b421653221 . _:b421652947 . _:b421653460 . _:b421651817 "5"^^ . _:b421652948 . _:b421652949 . _:b421652463 . . _:b421653292 "2"^^ . _:b421652950 . _:b421652951 . _:b421653463 . _:b421651816 "5"^^ . . . _:b421652936 . _:b421652937 . _:b421652938 . _:b421653295 "2"^^ . _:b421653271 . _:b421652939 . _:b421653462 . _:b421653346 . . _:b6691594 "targeted C/EBP\u03B2 and Stat3 in the human glioma cell line SNB19 and in serum-free cultures of tumor cells derived from primary GBM that propel the formation of GBM-like tumors after intracranial transplantation in immunodeficient mice>>30<< (GBM-derived brain tumor initiating cells, GBM-BTICs, see Fig. 5c\u2013g). We generated a global dataset of 89 individual samples, including 55 knockdown experiments in human glioma cells and 34 ectopic expression experiments in mouse NSCs." . _:b421652940 . _:b421651819 "5"^^ . _:b421652941 . _:b421652942 . _:b421653294 "2"^^ . _:b421652943 . _:b421653457 . _:b421651818 "5"^^ . _:b421652928 . _:b421652929 . _:b421652340 . _:b421652930 . _:b421653289 "2"^^ . _:b421651829 "4"^^ . _:b421653456 . _:b421652931 . _:b421652932 . _:b421652933 . . _:b421653288 "2"^^ . _:b421652626 . _:b421652934 . _:b421651828 "4"^^ . _:b421653459 . _:b421652935 . _:b421652920 . _:b421652921 . _:b421652922 . _:b421653291 "2"^^ . _:b421651831 "4"^^ . _:b421653458 . _:b421652923 . . _:b421652924 . _:b421653155 . _:b421652782 . _:b421652925 . _:b6691565 "Immunohistochemistry of primary human GBM was performed as previously described>>52<<. The primary antibodies and dilutions were: anti-YKL40 (rabbit polyclonal, Quidel, 1:750), anti C/EBP\u03B2, (rabbit polyclonal, Santa Cruz, 1:250) and anti-p-Stat3 (rabbit monoclonal, Cell Signaling, 1;25), Scoring for YKL40 was based on a" . _:b421652926 . _:b421653290 "2"^^ . _:b421651830 "4"^^ . _:b421653469 . _:b421652927 . . . _:b421652912 . _:b421652913 . _:b421652551 . _:b421652914 . _:b421653301 "2"^^ . _:b421651825 "4"^^ . _:b421653468 . _:b421652337 . _:b421652915 . _:b421652916 . _:b421653130 . _:b421652917 . . _:b421653300 "2"^^ . _:b421652918 . _:b421651824 "4"^^ . _:b421653471 . _:b421652919 . _:b421652904 . _:b421652905 . _:b421652906 . _:b421653303 "2"^^ . _:b421651827 "4"^^ . _:b421653470 . _:b421652907 . _:b421652908 . _:b421651827 . _:b421652909 . _:b421652910 . _:b421653302 "2"^^ . _:b421651826 "4"^^ . _:b421653465 . _:b421652911 . _:b421652896 . _:b421652897 . _:b421652898 . _:b421653297 "2"^^ . _:b421651837 "4"^^ . _:b421653464 . _:b421652899 . _:b421652900 . _:b421652688 . _:b421652901 . _:b421652902 . _:b421653296 "2"^^ . _:b421651836 "4"^^ . _:b421653645 . _:b421653467 . _:b421652903 . _:b421652888 . _:b421652889 . _:b421652890 . _:b421653299 "2"^^ . . _:b421651839 "4"^^ . _:b421653466 . _:b421652891 . _:b421651785 . _:b421652892 . . _:b421652893 . _:b421652534 . _:b421652894 . _:b421653298 "2"^^ . _:b421651838 "4"^^ . _:b421653477 . _:b421652895 . _:b421652880 . _:b421652881 . _:b421653304 . . _:b421653309 "2"^^ . _:b421652882 . . _:b421651833 "4"^^ . _:b421653476 . _:b421652883 . _:b421652884 . _:b421652885 . _:b421652886 . _:b421653308 "2"^^ . _:b421651832 "4"^^ . _:b421653479 . _:b421652887 . . _:b421652872 . _:b421652873 . _:b421653684 . _:b421652874 . _:b421653311 "2"^^ . _:b421652999 . _:b421651835 "4"^^ . _:b421653478 . _:b421652875 . _:b421652876 . _:b421652877 . _:b421652878 . _:b421653310 "2"^^ . _:b421651834 "4"^^ . _:b421653473 . _:b421653101 . _:b421652879 . _:b421652864 . _:b421652865 . _:b421652866 . _:b421653305 "2"^^ . . _:b421653472 . _:b421652867 . _:b421651845 "4"^^ . _:b421652868 . _:b421652869 . _:b421653195 . _:b421652870 . _:b421653304 "2"^^ . _:b421651844 "4"^^ . _:b421653475 . _:b421652871 . _:b421652856 . _:b421651584 . _:b421652857 . _:b421652858 . _:b421653307 "2"^^ . _:b421651847 "4"^^ . _:b421653474 . _:b421652859 . _:b421651707 . _:b421652860 . _:b421652861 . _:b421652862 . _:b421653306 "2"^^ . _:b421651846 "4"^^ . _:b421653485 . _:b421652538 . _:b421652863 . _:b421652848 . _:b421652849 . _:b421652850 . _:b421653490 . _:b421653317 "2"^^ . . _:b421653484 . _:b421652851 . _:b421651841 "4"^^ . _:b421652852 . _:b421652853 . _:b421653308 . _:b421652854 . _:b421653316 "2"^^ . _:b421651840 "4"^^ . _:b421653487 . _:b421652855 . _:b421652840 . _:b421652841 . _:b421652842 . _:b421653484 . _:b421653319 "2"^^ . _:b421652856 . _:b421651843 "4"^^ . _:b421653486 . _:b421652843 . . _:b421652521 . _:b421652844 . . _:b421652845 . _:b421652846 . _:b421653318 "2"^^ . . _:b421653481 . _:b421652847 . 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"2"^^ . _:b421652722 . _:b421651873 "4"^^ . _:b6691573 "cells whereas it operates to permanently drive the aberrant mesenchymal phenotype in the context of the genetic and epigenetic changes that accompany high-grade gliomagenesis (EGFR amplification, PTEN loss, Akt activation, etc.)>>4<<. Since expression of C/EBP\u03B2 and Stat3 in human glioma is essential to maintain the tumor initiating capacity and the ability to invade the normal brain, the two TFs provide important clues for diagnostic and pharmacological intervention." . _:b421653004 . _:b421652723 . _:b421652724 . . _:b421652725 . _:b421651531 . _:b421653348 "2"^^ . _:b421652726 . _:b421651872 "4"^^ . _:b421653007 . _:b421652727 . . _:b421652712 . . _:b421652713 . _:b421651530 . _:b421653351 "2"^^ . _:b421652714 . _:b421651875 "4"^^ . _:b421653006 . _:b421652715 . _:b421652716 . _:b421652717 . _:b421651541 . _:b421653350 "2"^^ . _:b421652718 . _:b421651874 "4"^^ . _:b421653001 . _:b421652719 . _:b421652704 . _:b421652705 . _:b421653196 . _:b421651540 . _:b421653345 "2"^^ . _:b421652311 . _:b421652706 . _:b421651885 "4"^^ . _:b421653000 . _:b421652707 . _:b421652708 . _:b421652709 . _:b421651543 . _:b421653344 "2"^^ . _:b421652710 . _:b421651884 "4"^^ . _:b421653329 . _:b421653003 . _:b421652711 . _:b421652696 . _:b421652697 . _:b421651542 . _:b421653347 "2"^^ . _:b421652698 . . _:b421653002 . _:b421652699 . _:b421651887 "4"^^ . _:b421652700 . _:b421652536 . _:b421652701 . _:b421651537 . _:b421653346 "2"^^ . _:b421652702 . _:b421651886 "4"^^ . _:b421653013 . _:b421652703 . _:b421652688 . _:b421652689 . . _:b421651536 . _:b421653357 "2"^^ . _:b421652690 . _:b421651881 "4"^^ . _:b421653012 . _:b421652691 . _:b421652692 . _:b421652693 . _:b421651539 . _:b421653356 "2"^^ . _:b421652621 . . _:b421652694 . . _:b421653015 . _:b421652695 . . _:b421651880 "4"^^ . _:b421652680 . _:b421652681 . _:b421651538 . _:b421653394 . _:b421653359 "2"^^ . _:b421652682 . _:b421651883 "4"^^ . _:b421653014 . _:b421652753 . _:b421652683 . _:b421652684 . . _:b421652685 . _:b421651549 . _:b421653358 "2"^^ . _:b421652903 . _:b421652686 . _:b421651882 "4"^^ . _:b421653009 . _:b421652687 . _:b421652672 . _:b421653653 . _:b421652673 . _:b421651548 . _:b421653353 "2"^^ . _:b421652674 . _:b421651893 "4"^^ . _:b6691564 "Immunostaining was performed as previously described>>51<<. Primary antibodies and dilutions:" . _:b421653008 . _:b421652675 . _:b421652676 . . _:b421652677 . _:b421651551 . _:b421653352 "2"^^ . _:b421652678 . _:b421651892 "4"^^ . _:b421653011 . _:b421652679 . _:b421652664 . _:b421652665 . _:b421653469 . _:b421653450 . _:b421651550 . _:b421653355 "2"^^ . _:b421652666 . _:b421651895 "4"^^ . _:b421653020 . _:b421653010 . _:b421652667 . _:b421652668 . _:b421652669 . _:b421651545 . _:b421653354 "2"^^ . _:b421651747 . _:b421652670 . _:b421651894 "4"^^ . _:b421653021 . _:b421652671 . _:b421652656 . _:b421652657 . _:b421651544 . _:b421653365 "2"^^ . _:b421652658 . _:b421651889 "4"^^ . _:b421653020 . _:b421652659 . _:b421652660 . _:b421652661 . _:b421653225 . _:b421652586 . _:b421651547 . _:b421653364 "2"^^ . _:b421652662 . _:b421651888 "4"^^ . _:b421653023 . _:b421652969 . _:b421652663 . _:b421652648 . _:b421652649 . _:b421651546 . _:b421653367 "2"^^ . _:b421652650 . _:b421651891 "4"^^ . _:b421653141 . _:b421653022 . _:b421652808 . _:b421652651 . . _:b421652652 . _:b421652653 . _:b421652037 . _:b421651557 . _:b421653366 "2"^^ . _:b421652654 . . _:b421653017 . _:b421652655 . _:b421651890 "4"^^ . _:b421652640 . _:b421652641 . _:b421651556 . _:b421653361 "2"^^ . _:b421652642 . _:b421651901 "4"^^ . _:b421653016 . _:b421652143 . _:b421652643 . _:b421652644 . _:b421652645 . _:b421651559 . _:b421653360 "2"^^ . _:b421652646 . _:b421651900 "4"^^ . _:b421653019 . _:b421652647 . _:b421652632 . _:b421651758 . _:b421652633 . _:b421651558 . _:b421653363 "2"^^ . _:b421652634 . _:b421651903 "4"^^ . _:b421653018 . _:b421652635 . . _:b421652636 . _:b421652637 . . _:b6691573 . _:b421653674 . _:b421653362 "2"^^ . _:b421652638 . _:b421651553 . _:b421651902 "4"^^ . _:b421653029 . _:b421652639 . _:b421652624 . _:b421652625 . _:b421651552 . _:b421653373 "2"^^ . _:b421652626 . _:b421651897 "4"^^ . _:b421653028 . _:b421652627 . _:b421652628 . _:b421651538 . _:b421652629 . _:b421651555 . _:b421653372 "2"^^ . _:b421652630 . _:b421651896 "4"^^ . _:b421653031 . _:b421652631 . _:b421652616 . . _:b421652617 . _:b421651554 . _:b421653375 "2"^^ . _:b421652618 . _:b421651899 "4"^^ . _:b421653030 . _:b421652619 . _:b421652620 . _:b6691590 . _:b421652043 . _:b421652621 . _:b421651565 . _:b421653374 "2"^^ . _:b421652622 . . _:b421651898 "4"^^ . _:b421653239 . _:b421653025 . _:b421652623 . _:b421651736 . _:b421652608 . _:b421652609 . . . _:b421653369 "2"^^ . _:b421652610 . _:b421651564 . _:b421651909 "4"^^ . _:b421653024 . _:b421652611 . _:b421652612 . _:b421653388 . . _:b421652613 . _:b421651567 . _:b421653368 "2"^^ . _:b421652614 . . . _:b421653027 . _:b421652615 . _:b421651908 "4"^^ . _:b421652600 . . _:b421652557 . _:b421652601 . _:b421651566 . _:b6691580 . _:b421653371 "2"^^ . _:b421652602 . _:b421651911 "4"^^ . _:b421653026 . _:b421652603 . . _:b421652604 . _:b421652605 . _:b6691571 "Interestingly, C/EBP\u03B2 and Stat3 are expressed in the developing nervous system>>35<<\u201338. However, while Stat3 induces astrocyte differentiation and inhibits neuronal differentiation of neural stem/progenitor cells, C/EBP\u03B2 promotes neurogenesis and opposes gliogenesis39\u201341. How can the combined activity of C/EBP\u03B2 and Stat3" . _:b421651561 . _:b421653370 "2"^^ . _:b421652606 . _:b421651910 "4"^^ . _:b421653037 . _:b421652607 . _:b421652592 . _:b421652593 . _:b421651560 . _:b6691554 . _:b421653381 "2"^^ . _:b421652594 . _:b421651905 "4"^^ . _:b421653036 . _:b421652595 . _:b421652596 . _:b421652597 . _:b421651563 . _:b421653380 "2"^^ . _:b421652598 . _:b421651904 "4"^^ . _:b421653039 . _:b421652599 . . _:b421652584 . _:b421652585 . _:b421653333 . _:b421651562 . _:b6691552 . _:b421653383 "2"^^ . _:b421652586 . . _:b421653498 . _:b421653038 . _:b421652587 . _:b421651907 "4"^^ . _:b421652588 . _:b421652589 . _:b421651573 . _:b421653382 "2"^^ . _:b421652590 . _:b421651718 . _:b421653033 . _:b421652591 . _:b421651906 "4"^^ . . _:b421652576 . _:b421652577 . _:b421653413 . . _:b421653377 "2"^^ . _:b421652578 . _:b421651572 . _:b421651917 "4"^^ . _:b421653032 . _:b421652579 . _:b421652580 . _:b421652581 . _:b421651575 . _:b421653376 "2"^^ . _:b421652582 . _:b421651916 "4"^^ . _:b421653035 . _:b421652583 . _:b421652568 . _:b421652569 . _:b421651574 . _:b421653379 "2"^^ . _:b421652870 . _:b421652570 . . _:b421653034 . _:b421652571 . _:b421651919 "4"^^ . _:b421652572 . _:b421652464 . _:b421652573 . _:b421651569 . _:b421653378 "2"^^ . _:b421652291 . _:b421652574 . . _:b421651918 "4"^^ . _:b421653045 . _:b421652575 . _:b421652560 . _:b421652561 . _:b421651568 . _:b421653389 "2"^^ . _:b421653135 . _:b421652562 . _:b421651913 "4"^^ . _:b421653044 . _:b421652563 . _:b421652564 . . _:b421651963 . _:b421652565 . _:b421651571 . _:b421653388 "2"^^ . _:b421652566 . _:b421651600 . _:b421653047 . _:b421652567 . _:b421651912 "4"^^ . _:b421652552 . _:b421652553 . _:b421651570 . _:b421653391 "2"^^ . _:b421652554 . _:b421651915 "4"^^ . _:b421653046 . _:b421652555 . _:b421652556 . _:b421652557 . _:b421651581 . _:b421653390 "2"^^ . _:b421652558 . . _:b421653041 . _:b421652559 . _:b421651914 "4"^^ . _:b421652544 . _:b421652730 . _:b421652545 . _:b421651580 . _:b421653385 "2"^^ . _:b421652546 . _:b421651925 "4"^^ . _:b421653040 . _:b421652547 . _:b421652548 . _:b421652549 . _:b421651583 . _:b421653384 "2"^^ . _:b421652550 . _:b421651924 "4"^^ . _:b421653043 . _:b421652551 . _:b421652536 . _:b421652711 . _:b421652537 . _:b421651582 . _:b421653387 "2"^^ . _:b421651998 . _:b421652538 . _:b421651927 "4"^^ . _:b421653042 . _:b421652308 . _:b421652539 . _:b421652540 . . . _:b421652840 . _:b421652541 . _:b421651577 . _:b421653386 "2"^^ . _:b421652542 . . _:b421651926 "4"^^ . _:b421653053 . _:b421652698 . _:b421652543 . _:b421652528 . _:b421651728 . _:b421652529 . _:b421653659 . . _:b421651576 . _:b421653397 "2"^^ . _:b421652530 . . _:b421653052 . _:b421652531 . _:b421651921 "4"^^ . _:b421652532 . . _:b421652533 . _:b421651579 . _:b421653396 "2"^^ . _:b421652534 . _:b421651920 "4"^^ . _:b421653055 . _:b421652535 . . _:b421652520 . _:b421652521 . _:b421651578 . _:b421653399 "2"^^ . _:b421652522 . _:b421651923 "4"^^ . _:b421653054 . _:b421652523 . . _:b421652525 . _:b421652244 . _:b421652524 . _:b421652525 . _:b421651589 . _:b421653398 "2"^^ . _:b421652526 . _:b421651922 "4"^^ . _:b421653049 . _:b421652527 . _:b421652512 . _:b421652513 . _:b421651588 . _:b421653393 "2"^^ . _:b421652514 . _:b421651981 . _:b421651933 "4"^^ . _:b421653048 . _:b421652515 . _:b421652516 . _:b421652517 . _:b421651591 . _:b421653392 "2"^^ . _:b421652518 . _:b421651932 "4"^^ . _:b421653051 . _:b421652519 . _:b421652504 . _:b421652505 . _:b421653722 . _:b421651590 . _:b421653395 "2"^^ . _:b421652506 . _:b421651596 . . _:b421653050 . _:b421652507 . _:b421651935 "4"^^ . _:b421652508 . _:b421652509 . _:b421651585 . _:b421653394 "2"^^ . _:b421652510 . _:b421651934 "4"^^ . _:b421653061 . _:b421652511 . . _:b421652496 . . _:b421652497 . _:b421651584 . _:b421653405 "2"^^ . _:b421652498 . _:b421651929 "4"^^ . _:b421653060 . _:b421652499 . _:b421652500 . _:b421652501 . _:b421651587 . _:b421653404 "2"^^ . _:b421652502 . . _:b421653063 . _:b421652503 . _:b421651928 "4"^^ . _:b421652488 . _:b421653672 . _:b421652489 . _:b421651586 . _:b421653407 "2"^^ . _:b421652490 . _:b421651931 "4"^^ . _:b421653062 . _:b421652491 . . _:b421652492 . _:b421652322 . _:b421652493 . _:b421651597 . _:b421653406 "2"^^ . _:b421653390 . _:b421652494 . _:b421651930 "4"^^ . _:b421653057 . _:b421652495 . _:b421652480 . _:b421652481 . _:b421651596 . _:b421653401 "2"^^ . _:b421652482 . _:b421651941 "4"^^ . _:b421653056 . _:b421652483 . _:b421652484 . _:b421652485 . _:b421651599 . _:b421653400 "2"^^ . _:b421652486 . . _:b421653059 . _:b421652487 . _:b421651940 "4"^^ . _:b421653496 . . _:b421653460 . _:b421653497 . _:b421651598 . _:b421653403 "2"^^ . _:b421653498 . _:b421651943 "4"^^ . _:b421653058 . _:b421653499 . _:b421653500 . . _:b421653501 . _:b421651593 . _:b421653402 "2"^^ . _:b421653502 . _:b421651942 "4"^^ . _:b421653069 . _:b421653503 . _:b421653488 . _:b421653765 . _:b421653489 . _:b421651592 . _:b421653413 "2"^^ . _:b421653490 . _:b421651937 "4"^^ . _:b421653068 . _:b421651717 . _:b421653491 . _:b421653492 . _:b421653493 . _:b421651595 . _:b6691587 . _:b421653412 "2"^^ . _:b421653494 . _:b421651936 "4"^^ . _:b421653071 . _:b421653495 . _:b421653480 . _:b421652569 . _:b421653481 . _:b421651594 . _:b421653415 "2"^^ . _:b421653405 . _:b421653482 . _:b421651939 "4"^^ . _:b421653070 . _:b421653483 . _:b421653484 . _:b421653485 . _:b421651605 . _:b421653414 "2"^^ . _:b421653486 . _:b421651938 "4"^^ . _:b421653065 . _:b421653487 . . _:b421653472 . _:b421653473 . . _:b6691572 "However, while Stat3 induces astrocyte differentiation and inhibits neuronal differentiation of neural stem/progenitor cells, C/EBP\u03B2 promotes neurogenesis and opposes gliogenesis>>39<<\u201341. How can the combined activity of C/EBP\u03B2 and Stat3 reprogram NSCs toward an aberrant lineage (mesenchymal) and oppose the genesis of the normal neural lineages (neuronal and glial)? We propose that mesenchymal transformation results" . _:b421653409 "2"^^ . _:b421652573 . _:b421653474 . _:b421651604 . . _:b421653064 . _:b421652981 . _:b421653475 . _:b421651949 "4"^^ . . _:b421653476 . . . _:b421653477 . _:b421651607 . _:b421653408 "2"^^ . _:b421653478 . _:b421651948 "4"^^ . _:b421653067 . _:b421653479 . _:b421651671 . _:b421653464 . . _:b421653465 . _:b421651606 . _:b421653411 "2"^^ . _:b421653466 . _:b421651951 "4"^^ . _:b421653066 . _:b421653467 . . _:b421653468 . . . _:b421653469 . . _:b421653410 "2"^^ . _:b421653470 . _:b421651601 . _:b421651950 "4"^^ . _:b421653077 . _:b421653471 . . _:b421653456 . _:b421653457 . . _:b421653421 "2"^^ . _:b421653458 . _:b421651600 . _:b421651674 . _:b421653076 . _:b421652107 . _:b421653459 . _:b421651945 "4"^^ . _:b421653460 . _:b421653461 . _:b421651603 . _:b421653420 "2"^^ . _:b421653462 . . _:b421651944 "4"^^ . _:b421653079 . _:b421653463 . _:b421653448 . _:b421653449 . _:b421651602 . _:b421653423 "2"^^ . _:b421653450 . _:b421651947 "4"^^ . _:b421653078 . _:b421653451 . _:b421653452 . _:b421653453 . _:b421651613 . _:b421653422 "2"^^ . _:b421652254 . _:b421653454 . _:b421651946 "4"^^ . _:b421653073 . _:b421653455 . . _:b421653440 . _:b421651958 . _:b421653441 . _:b421651612 . _:b421653417 "2"^^ . _:b421653442 . _:b421651957 "4"^^ . _:b421653072 . _:b421653443 . _:b421653444 . _:b421653445 . _:b421651743 . _:b421653416 "2"^^ . _:b421653125 . _:b421653446 . _:b421651642 . _:b421651615 . _:b421651956 "4"^^ . _:b421653075 . _:b421653447 . _:b421653432 . . _:b421653433 . _:b421651614 . _:b421653419 "2"^^ . _:b421652982 . _:b421653434 . _:b421651959 "4"^^ . _:b421653074 . _:b421653435 . . _:b421653436 . _:b421651703 . _:b421653437 . _:b421651609 . _:b421653418 "2"^^ . _:b421653438 . _:b421651958 "4"^^ . _:b421653085 . _:b421653439 . _:b421653424 . _:b421653425 . _:b421651608 . _:b421653429 "2"^^ . _:b421653426 . _:b421651953 "4"^^ . _:b421653084 . _:b421653427 . . _:b421653428 . _:b421653429 . _:b421651611 . _:b421653428 "2"^^ . _:b421653430 . . _:b421651952 "4"^^ . _:b421653118 . _:b421653087 . _:b421653431 . . _:b421653416 . _:b421653417 . _:b421651610 . _:b421653431 "2"^^ . _:b421653418 . _:b421651955 "4"^^ . _:b421653086 . _:b421653419 . _:b421653420 . _:b421653407 . _:b421653421 . _:b421651867 . _:b421653430 "2"^^ . _:b421653422 . _:b421651621 . _:b421651954 "4"^^ . _:b421653081 . _:b421653423 . _:b421653408 . _:b421653409 . _:b421653352 . _:b421651620 . _:b421653425 "2"^^ . _:b421653410 . _:b421651965 "4"^^ . _:b421653080 . _:b421653411 . . _:b421653412 . _:b421651838 . _:b421653413 . _:b421651623 . _:b421653424 "2"^^ . _:b421653414 . _:b421651964 "4"^^ . _:b421653083 . _:b421653415 . _:b421653400 . _:b421652826 . _:b421653401 . _:b421651622 . _:b421653427 "2"^^ . _:b421653402 . _:b421651967 "4"^^ . _:b421653082 . _:b421653403 . _:b421653404 . _:b421653405 . _:b421651617 . _:b421653426 "2"^^ . _:b421653290 . _:b421653406 . _:b421651966 "4"^^ . _:b421653093 . _:b421653407 . _:b421653392 . _:b421653393 . _:b421651616 . _:b421653437 "2"^^ . _:b421651905 . _:b421653394 . _:b421651961 "4"^^ . _:b421653092 . _:b421653395 . . _:b421653396 . _:b421653397 . _:b421651618 . _:b421653436 "2"^^ . _:b421653398 . _:b421651619 . _:b421651960 "4"^^ . _:b421653095 . _:b421653399 . _:b421653384 . _:b421653385 . _:b421651618 . _:b421653439 "2"^^ . _:b421653386 . _:b421651963 "4"^^ . _:b421653094 . _:b421653387 . _:b421653388 . _:b421653493 . _:b421652720 . _:b421653389 . _:b421651629 . _:b421653438 "2"^^ . _:b421651766 . _:b421653390 . _:b421651962 "4"^^ . _:b421653089 . _:b421653391 . _:b421653376 . _:b421653377 . _:b421651693 . _:b421651628 . _:b421653433 "2"^^ . _:b421653245 . _:b421653378 . _:b421653379 . _:b421653088 . _:b421653380 . _:b421653381 . _:b421651631 . _:b421653432 "2"^^ . _:b421653382 . _:b421653383 . _:b421653091 . _:b421651630 . _:b421653368 . _:b421653532 . _:b421653369 . _:b421651630 . _:b421653435 "2"^^ . _:b421653370 . _:b421653371 . _:b421653090 . _:b421653372 . _:b421652197 . _:b421653373 . _:b421651625 . _:b421653434 "2"^^ . _:b421653374 . _:b421653375 . _:b421653101 . _:b421653360 . _:b421653063 . . _:b421653361 . _:b421651624 . _:b421653445 "2"^^ . _:b421653362 . . _:b421653100 . _:b421652852 . _:b421653363 . _:b421653364 . . _:b421653365 . _:b421651627 . _:b421653444 "2"^^ . _:b421653366 . _:b421653367 . _:b421653103 . _:b421653352 . _:b421653164 . . _:b421653353 . _:b421651626 . _:b421653610 . _:b421653447 "2"^^ . _:b421653354 . _:b421653355 . _:b421653102 . _:b421653356 . _:b421652209 . . _:b421653357 . _:b421651637 . _:b421653446 "2"^^ . _:b421653358 . _:b421653359 . _:b421653097 . _:b421653344 . _:b421653345 . _:b421651636 . _:b421653530 . _:b421653441 "2"^^ . _:b421653346 . _:b421653347 . _:b421653193 . _:b421653096 . _:b421653005 . _:b421653348 . _:b421653349 . _:b421651639 . _:b421653440 "2"^^ . _:b421653350 . _:b421653351 . _:b421653099 . _:b421653336 . . _:b421653337 . . _:b421651638 . _:b421653443 "2"^^ . _:b421652500 . _:b421653338 . . _:b421653098 . _:b421653339 . . _:b421653340 . _:b421653341 . _:b421653148 . _:b421651633 . _:b421653442 "2"^^ . _:b421653342 . _:b421653343 . _:b421653179 . _:b421653109 . . . _:b421653328 . . _:b421653329 . . _:b421653453 "2"^^ . _:b421652450 . _:b421653330 . . _:b421651632 . _:b421653331 . _:b421653108 . _:b421653332 . _:b421653333 . _:b421651635 . _:b421653452 "2"^^ . _:b421653334 . _:b421653335 . _:b421653111 . _:b421653320 . _:b421653321 . _:b421651634 . _:b421653455 "2"^^ . _:b421653322 . _:b421651901 . _:b421653110 . _:b421653323 . _:b421653324 . _:b421653325 . _:b421651645 . _:b421653454 "2"^^ . _:b421653326 . _:b421653327 . _:b421653105 . _:b421653312 . . _:b421653313 . _:b421651644 . _:b421653449 "2"^^ . _:b421653314 . . _:b421653104 . _:b421653315 . . _:b421653316 . _:b421653317 . _:b421652666 . _:b421651647 . _:b421653448 "2"^^ . _:b421653318 . _:b421653319 . _:b421653107 . _:b421652276 . _:b421653304 . . _:b421652717 . _:b421653305 . 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. _:b421653254 . _:b421653255 . _:b421653123 . _:b421653240 . _:b421653241 . _:b421651662 . _:b421653467 "2"^^ . _:b421653242 . _:b421653243 . _:b421653122 . _:b421653244 . _:b6691571 . _:b421653245 . _:b421651657 . _:b421653466 "2"^^ . _:b421653246 . _:b421653247 . _:b421653133 . _:b421653232 . _:b421653233 . _:b421651656 . _:b421653477 "2"^^ . _:b421653234 . _:b421653235 . _:b421653132 . . _:b421653236 . _:b421653237 . _:b421651659 . _:b421653476 "2"^^ . _:b421653238 . . _:b421653135 . _:b421653239 . . _:b421653224 . . _:b421653225 . . _:b421651658 . _:b421653479 "2"^^ . _:b421653226 . _:b421651697 . _:b421653134 . _:b421653227 . _:b421653228 . _:b421653229 . _:b421651669 . _:b421653478 "2"^^ . _:b421653230 . _:b421653231 . _:b421653129 . _:b421653071 . _:b421653216 . _:b421653217 . _:b421651668 . _:b421653473 "2"^^ . _:b421653218 . _:b421653219 . _:b421653128 . . _:b421653220 . . _:b421652618 . _:b421653221 . _:b421651671 . _:b421653472 "2"^^ . _:b421653222 . _:b421653223 . _:b421653131 . _:b421653208 . _:b421653209 . _:b421651670 . _:b421653475 "2"^^ . _:b421653210 . _:b421653211 . _:b421653130 . _:b421653212 . . _:b421652285 . _:b421653213 . _:b421651665 . _:b421653474 "2"^^ . _:b421653214 . _:b421653215 . _:b421653141 . _:b421653200 . _:b421653177 . _:b421653201 . _:b421651664 . _:b421653485 "2"^^ . _:b421653202 . _:b421653203 . _:b421653140 . _:b421653204 . . _:b421653205 . _:b421651667 . _:b421653484 "2"^^ . _:b421653206 . _:b421653207 . _:b421653143 . . _:b421653192 . _:b421653193 . _:b421652123 . _:b421651666 . _:b421653487 "2"^^ . _:b421653194 . _:b421651937 . _:b421653142 . _:b421653195 . _:b421653196 . . _:b421653197 . . _:b421651677 . _:b421653749 . _:b421653486 "2"^^ . _:b421652961 . _:b421653198 . _:b421653199 . _:b421653137 . _:b421653184 . _:b421653185 . _:b421651676 . _:b421653481 "2"^^ . _:b421653321 . _:b421653186 . . _:b421653187 . _:b421653136 . _:b421653188 . . _:b421653189 . _:b421652873 . _:b421651679 . _:b421653480 "2"^^ . _:b421653190 . _:b421653191 . _:b421653139 . _:b421653176 . _:b421653177 . _:b421651678 . _:b421653483 "2"^^ . _:b421653178 . _:b421653179 . _:b421653138 . . _:b421653262 . _:b421653180 . _:b421653181 . . _:b421653482 "2"^^ . _:b421653182 . _:b421651673 . _:b421653183 . _:b421653149 . _:b421653168 . _:b421653169 . _:b421652974 . _:b421651672 . _:b421653493 "2"^^ . _:b421653170 . _:b421653171 . _:b421653148 . _:b421653172 . _:b421653173 . _:b421651675 . _:b421653492 "2"^^ . _:b421653174 . . _:b421653151 . _:b421653175 . _:b421653160 . _:b421653161 . _:b421651674 . _:b421653495 "2"^^ . _:b421653162 . _:b421653163 . _:b421653150 . _:b421652496 . . _:b421653164 . _:b421653165 . _:b421651685 . _:b421653494 "2"^^ . _:b421653166 . _:b421653167 . _:b421653145 . . _:b421653152 . _:b421653153 . _:b421651684 . _:b421653489 "2"^^ . _:b421653154 . _:b421653155 . _:b421653144 . _:b421653156 . . _:b421653157 . _:b421651687 . _:b421653488 "2"^^ . _:b421653158 . . _:b421653147 . _:b421653159 . _:b421653144 . _:b421653145 . _:b421652921 . _:b421651686 . _:b421653491 "2"^^ . _:b421653146 . _:b421653147 . _:b421653146 . _:b421653148 . _:b421653149 . . _:b421653490 "2"^^ . _:b421653150 . _:b421651681 . _:b421653151 . _:b421653157 . . _:b421653136 . _:b421653137 . _:b421651680 . _:b421653501 "2"^^ . _:b421653138 . _:b421653139 . _:b421653156 . . _:b421653140 . _:b421651996 . . _:b421652757 . _:b421653141 . _:b421651683 . _:b421653500 "2"^^ . _:b421653142 . _:b421653143 . _:b421653159 . _:b421653128 . . _:b421652748 . _:b421652694 . _:b421653129 . . _:b421651682 . _:b421653503 "2"^^ . _:b421653130 . . _:b421653131 . _:b421653158 . _:b421653132 . _:b421651896 . _:b421653133 . . _:b421651693 . _:b421653502 "2"^^ . _:b421653134 . _:b421653135 . _:b421653153 . _:b421653120 . _:b421653121 . _:b421653476 . . _:b421653497 "2"^^ . _:b421653122 . _:b421651692 . _:b421653123 . _:b421653152 . . _:b421653124 . . _:b421653125 . _:b421651695 . _:b421653496 "2"^^ . _:b421653126 . . _:b421653155 . _:b421653127 . _:b421653112 . . _:b421653113 . _:b421651991 . _:b421653499 "2"^^ . _:b421653114 . . _:b421651694 . _:b421653115 . _:b421653154 . _:b421653116 . _:b421653117 . _:b421651689 . _:b421653498 "2"^^ . _:b421653118 . _:b421653119 . _:b421653165 . _:b421653104 . _:b421653105 . _:b6691563 "Immunofluorescence staining was performed as previously described>>50<<. Primary antibodies and dilutions were: SMA (mouse monoclonal, Sigma, 1:200), Fibronectin (mouse monoclonal, BD Biosciences, 1:" . _:b421652069 . _:b421651688 . _:b421652485 "2"^^ . _:b421653106 . _:b421653107 . _:b421653164 . _:b421653108 . _:b421652357 . _:b421653109 . _:b421653571 . _:b421651691 . _:b421653236 . _:b421652484 "2"^^ . _:b421653110 . . _:b421653167 . _:b421653111 . _:b421653096 . _:b421653097 . _:b421652600 . . _:b421652487 "2"^^ . _:b421652401 . _:b421653098 . _:b421651690 . _:b421653099 . _:b421653166 . _:b421653100 . . _:b421653101 . _:b421651701 . _:b421652486 "2"^^ . _:b421653102 . . _:b421653161 . _:b421653103 . . . _:b421653088 . _:b421653089 . _:b421653446 . _:b421651700 . _:b421652481 "2"^^ . _:b421653090 . _:b421653091 . _:b421653160 . _:b421653092 . _:b421653093 . . _:b421652738 . _:b421652480 "2"^^ . _:b421653094 . _:b421651703 . _:b421653095 . _:b421653163 . _:b421653080 . _:b421653081 . _:b421651702 . _:b421652483 "2"^^ . _:b421653082 . . _:b421653162 . _:b421653083 . _:b421653084 . _:b421653085 . _:b421652928 . _:b421651697 . _:b421652482 "2"^^ . _:b421653086 . . _:b421653087 . _:b421653173 . . _:b421653072 . . _:b421653073 . _:b421651696 . _:b421652493 "2"^^ . _:b421653074 . . _:b421653172 . _:b421653075 . . _:b421653076 . _:b421653077 . _:b421652713 . _:b421651823 . _:b421652608 . _:b421652492 "2"^^ . _:b421653078 . . _:b421651699 . . _:b421653079 . _:b421653175 . _:b421653064 . _:b421653065 . . _:b421652495 "2"^^ . _:b421653066 . _:b421651698 . _:b421653067 . _:b421653174 . . _:b421653068 . _:b421653069 . . _:b421652494 "2"^^ . _:b421653070 . . _:b421651709 . _:b421653071 . _:b421653169 . _:b421653056 . . _:b421653057 . _:b421651708 . _:b421652489 "2"^^ . _:b421653058 . _:b421653059 . _:b421653168 . _:b421653060 . _:b421653061 . _:b421652750 . . _:b421652488 "2"^^ . _:b421653062 . _:b421651711 . _:b421653063 . _:b421653171 . _:b421653048 . _:b421653049 . _:b421651710 . _:b421652491 "2"^^ . _:b421653050 . _:b421653051 . _:b421653170 . _:b421651563 . _:b421653052 . _:b421653053 . _:b421653741 . . _:b421652490 "2"^^ . _:b421653054 . _:b421651705 . _:b421653055 . _:b421653181 . _:b421653040 . . _:b421653041 . _:b421651704 . _:b421652501 "2"^^ . _:b421653042 . . _:b421653180 . _:b421653043 . _:b421653044 . _:b421653045 . _:b421651707 . _:b421652500 "2"^^ . _:b421653046 . . _:b421653183 . _:b421653047 . _:b421653032 . _:b421653033 . _:b421652267 . _:b421651706 . _:b421652503 "2"^^ . _:b421653034 . . _:b421653035 . _:b421653182 . _:b421653036 . . _:b421653037 . _:b421653038 . _:b421652502 "2"^^ . _:b421653039 . _:b421653177 . _:b421653024 . _:b421653025 . _:b421653026 . _:b421652497 "2"^^ . _:b421653027 . _:b421653176 . . _:b421653028 . _:b421653029 . _:b421653030 . _:b421652496 "2"^^ . . _:b421653179 . _:b421653031 . . . _:b421653016 . _:b421653017 . _:b421653018 . _:b421652499 "2"^^ . . _:b421653178 . _:b421652354 . _:b421653019 . _:b421653020 . _:b421653059 . _:b421653021 . _:b421653022 . _:b421652498 "2"^^ . _:b421653023 . _:b421653189 . _:b421653008 . _:b421653693 . . _:b421653009 . _:b421653010 . _:b421652509 "2"^^ . . _:b421653188 . _:b421653011 . _:b421653012 . _:b421653013 . _:b421653014 . _:b421652508 "2"^^ . _:b421653015 . _:b421653191 . _:b421653000 . _:b421653001 . . _:b421652511 "2"^^ . _:b421653002 . _:b421653003 . _:b421653492 . _:b421653190 . _:b421653004 . _:b421653109 . _:b421653005 . . _:b421652510 "2"^^ . _:b421653006 . . _:b421653428 . _:b421653185 . _:b421653007 . . _:b421652992 . _:b421652993 . _:b421652994 . _:b6691585 . _:b421652505 "2"^^ . _:b421652995 . _:b421653184 . _:b421652996 . . _:b421652997 . _:b421652998 . _:b421652504 "2"^^ . _:b421652999 . _:b421653187 . _:b421652299 . . _:b421652507 "2"^^ . _:b421653186 . . _:b421652506 "2"^^ . _:b421653197 . _:b421652995 . . _:b421652517 "2"^^ . _:b421653196 . . _:b421652208 . _:b421652516 "2"^^ . _:b421653199 . _:b421651650 . _:b421652544 . . _:b421652519 "2"^^ . _:b421653198 . _:b421652518 "2"^^ . _:b421653193 . _:b421652053 . _:b421652513 "2"^^ . . _:b421653192 . _:b421652512 "2"^^ . _:b421653195 . _:b421653268 . _:b421652990 . . _:b421652515 "2"^^ . _:b421653194 . _:b421652514 "2"^^ . _:b421653205 . _:b421652525 "2"^^ . _:b421653204 . _:b421651700 . _:b421652524 "2"^^ . _:b421651913 . _:b421653207 . _:b421652286 . _:b421652527 "2"^^ . _:b421653206 . _:b421652453 . . _:b421652526 "2"^^ . . _:b421653201 . . . _:b421652521 "2"^^ . _:b421653200 . . . _:b421652520 "2"^^ . _:b421653203 . _:b421651970 . _:b421653132 . _:b421652469 . _:b421652523 "2"^^ . _:b421652589 . _:b421653202 . . _:b6691568 "Recently, there have been several unsuccessful attempts to identify common expression signatures predictive of the same cellular phenotype>>33<<. Our approach produced virtually identical regulatory MR modules when applied to two completely distinct datasets and signatures associated with poor-prognosis in HGGs, thus indicating that MRs of mammalian phenotype signatures may be" . _:b421652233 . _:b421652522 "2"^^ . . _:b421653692 . _:b421653213 . _:b421652533 "2"^^ . _:b421653212 . _:b421652006 . _:b421652532 "2"^^ . _:b421651886 . _:b421653748 . _:b421653215 . . . _:b421652846 . . _:b421652535 "2"^^ . _:b421653214 . _:b421652563 . _:b421652534 "2"^^ . _:b421653209 . _:b421652325 . _:b421652529 "2"^^ . . _:b421653208 . _:b421652388 . _:b421653423 . _:b421651873 . _:b421652683 . _:b421652528 "2"^^ . _:b421653211 . . _:b421652531 "2"^^ . _:b421653210 . _:b421652530 "2"^^ . _:b421652850 . _:b421653221 . _:b421652191 . _:b421652541 "2"^^ . _:b421653220 . _:b421652540 "2"^^ . _:b421653123 . _:b421653223 . _:b421652426 . _:b421652543 "2"^^ . _:b6691555 . _:b421653222 . _:b421652542 "2"^^ . _:b421653217 . . _:b421652537 "2"^^ . . _:b421653216 . _:b421653152 . _:b421651601 . _:b421652536 "2"^^ . _:b421653766 . _:b421653219 . _:b421652394 . _:b421652539 "2"^^ . _:b421653218 . . _:b421652538 "2"^^ . _:b421653229 . . _:b421651989 . _:b421652549 "2"^^ . _:b421652732 . _:b6691582 "from 176 gene expression profiles of grade III (anaplastic astrocytoma) and grade IV (GBM) samples previously classified into three molecular signature groups \u2013 proneural, proliferative, and mesenchymal (Supplementary Table 1a\u2013c)4, 20, >>21<<. ARACNe is an information theoretic approach for the inference of TF-target interactions from large sets of gene expression profiles9, 16, further refined to infer directed (i.e. causal) interactions12, 22 (see Methods)." . _:b421653300 . _:b421653228 . _:b421652548 "2"^^ . _:b421653002 . _:b421653231 . . . . _:b421652551 "2"^^ . _:b421653230 . _:b421652239 . _:b421652024 . _:b421652047 . _:b421652550 "2"^^ . _:b421653225 . _:b421652182 . _:b421652545 "2"^^ . _:b421653224 . . _:b421652544 "2"^^ . _:b421653227 . . . _:b421652547 "2"^^ . _:b421653226 . _:b421651542 . _:b421652021 . _:b421652546 "2"^^ . _:b421653237 . _:b421653601 . _:b421652557 "2"^^ . . _:b421653236 . . . _:b421652556 "2"^^ . _:b421651938 . _:b6691584 "ARACNe is an information theoretic approach for the inference of TF-target interactions from large sets of gene expression profiles9, >>16<<, further refined to infer directed (i.e. causal) interactions12, 22 (see Methods)." . _:b421653628 . _:b421653239 . _:b421652559 "2"^^ . _:b421653238 . _:b421652558 "2"^^ . _:b421653233 . _:b421653525 . _:b421652553 "2"^^ . _:b421651955 . _:b421653232 . _:b421651765 . . _:b421652552 "2"^^ . _:b421651657 . _:b421653235 . _:b421652213 . _:b421651549 . _:b421652555 "2"^^ . _:b421653234 . . _:b421652554 "2"^^ . . _:b421653245 . _:b421652947 . _:b421652565 "2"^^ . _:b421653180 . _:b421653244 . _:b421653188 . _:b421652984 . _:b421652564 "2"^^ . _:b421653247 . _:b421652567 "2"^^ . _:b421652011 . _:b421653246 . . . _:b421652566 "2"^^ . _:b421653241 . _:b421652313 . _:b421652561 "2"^^ . . _:b421653240 . . _:b421652560 "2"^^ . _:b6691576 . _:b421653243 . . _:b421652563 "2"^^ . _:b421653242 . _:b421652181 . _:b6691582 . _:b421652562 "2"^^ . . _:b421652741 . _:b421652573 "2"^^ . _:b421652740 . . _:b421652572 "2"^^ . _:b421652743 . _:b421653768 . _:b421651915 . _:b421653769 . _:b421653770 . _:b421652575 "2"^^ . . _:b421652742 . _:b421652435 . _:b421653771 . _:b421652868 . _:b421652574 "2"^^ . . _:b421652737 . _:b421651583 . _:b421651627 . _:b421653760 . _:b421653761 . _:b421653014 . . _:b421652569 "2"^^ . _:b421653762 . _:b421653763 . _:b421652736 . . _:b421653764 . _:b421653765 . _:b421653766 . _:b421652568 "2"^^ . . _:b421652739 . _:b421653767 . _:b421653752 . _:b421652814 . _:b421653753 . _:b421653754 . _:b421652571 "2"^^ . . _:b421652738 . _:b421653755 . . _:b421653756 . _:b421653757 . . _:b421652570 "2"^^ . _:b421653758 . . _:b421652749 . _:b421653759 . _:b421653744 . _:b421653745 . _:b421653746 . _:b421652581 "2"^^ . . _:b421652748 . _:b421653747 . _:b421653748 . _:b421651866 . _:b421653749 . _:b421653750 . _:b421652580 "2"^^ . _:b421653751 . _:b421652770 . _:b421652751 . . _:b421653736 . . _:b421652223 . _:b421653737 . _:b421653738 . _:b421652583 "2"^^ . _:b421653739 . _:b421652750 . _:b421653740 . _:b421653741 . _:b421653742 . _:b421652582 "2"^^ . _:b421653743 . _:b421652745 . . _:b421653764 . _:b421653728 . _:b421651888 . _:b421653729 . _:b421653730 . _:b421652577 "2"^^ . _:b421653731 . _:b421652744 . _:b421653732 . _:b421653733 . _:b421653734 . _:b421652576 "2"^^ . _:b421653735 . _:b421652747 . _:b421653720 . _:b421652432 . _:b421653721 . _:b421653722 . _:b421652579 "2"^^ . _:b421653723 . _:b421652746 . . _:b421651676 . _:b421653724 . _:b421651987 . _:b421653725 . _:b421652658 . _:b421653726 . _:b421652578 "2"^^ . _:b421651824 . _:b421653727 . _:b421652757 . _:b421653712 . _:b421653713 . _:b6691553 . . _:b421653714 . _:b421652589 "2"^^ . . _:b421653715 . _:b421652756 . _:b421653716 . _:b421653717 . _:b421653718 . _:b421653475 . _:b421652588 "2"^^ . _:b421651934 . _:b421653719 . _:b421652759 . _:b421652070 . _:b421653704 . _:b421653705 . _:b421653706 . _:b421652591 "2"^^ . _:b421653707 . _:b421652758 . _:b421653708 . . _:b421653709 . _:b421651708 . . _:b421653710 . _:b421652590 "2"^^ . . . _:b421653711 . _:b421652753 . . _:b421653696 . _:b421653697 . _:b6691553 "The normalized copy number of each gene was interpolated based on the copy number of the nearest genomic clone on the CGH array as determined by comparison of the sequence annotation of both array platforms, as previously described>>21<<." . _:b421653698 . _:b421652585 "2"^^ . _:b421653699 . _:b421652752 . . _:b421653700 . _:b421653701 . _:b421651594 . _:b421653702 . _:b421652584 "2"^^ . _:b421652352 . . _:b421653703 . _:b421652755 . _:b421653688 . _:b421653108 . _:b421652199 . . _:b421653689 . _:b421653690 . _:b421652587 "2"^^ . _:b421653691 . _:b421652754 . _:b421653692 . _:b421653693 . . _:b421653694 . _:b421652586 "2"^^ . _:b421653695 . _:b421652765 . . _:b421651816 . _:b421653680 . _:b421653681 . _:b421653682 . _:b421652597 "2"^^ . _:b421653683 . _:b421652764 . _:b421653684 . _:b421653283 . _:b421652471 . _:b421653685 . _:b421653686 . _:b421652596 "2"^^ . _:b421653687 . _:b421652767 . _:b421653672 . _:b421653673 . _:b421653674 . _:b421652599 "2"^^ . _:b421651791 . _:b421653675 . _:b421653200 . _:b421652766 . _:b421653676 . _:b421653677 . _:b421653678 . _:b421653137 . _:b421652598 "2"^^ . _:b421653679 . _:b421652761 . _:b421651975 . _:b421653664 . _:b421653378 . _:b421653665 . _:b421653666 . _:b421652593 "2"^^ . _:b421653667 . _:b421652760 . _:b421653668 . _:b421653669 . _:b421653670 . _:b421652592 "2"^^ . _:b421653671 . _:b421652763 . _:b421653656 . . _:b421653657 . _:b421653658 . _:b421652595 "2"^^ . _:b421653659 . _:b421652762 . _:b421653660 . . . _:b421653661 . _:b421653662 . _:b421652594 "2"^^ . . _:b421653663 . _:b421652773 . _:b421653648 . _:b421653649 . . . _:b421653650 . _:b421652605 "2"^^ . _:b421653651 . _:b421652772 . _:b421653652 . . _:b421653653 . _:b421653654 . _:b421652604 "2"^^ . _:b421653655 . _:b421652775 . _:b421653640 . _:b421653641 . _:b421651714 . . _:b421653642 . _:b421652607 "2"^^ . _:b421653643 . _:b421652774 . . _:b421653644 . . "PMC0" . _:b421653645 . . _:b421653646 . _:b421652606 "2"^^ . _:b421653647 . _:b421652769 . _:b421652650 . _:b421653632 . . _:b421653633 . _:b421653634 . _:b421652601 "2"^^ . _:b421653635 . _:b421652768 . . _:b421653636 . . _:b421653637 . _:b421651902 . _:b421651878 . _:b421653638 . _:b421652600 "2"^^ . _:b421653639 . _:b421652771 . _:b421653624 . _:b421653625 . _:b421652351 . _:b421653626 . _:b421652603 "2"^^ . _:b421651917 . _:b421653627 . _:b421652770 . _:b421653628 . _:b421653629 . _:b421653630 . _:b421652602 "2"^^ . _:b421653631 . _:b421652781 . . _:b421653616 . _:b421653617 . . _:b421653618 . _:b421652613 "2"^^ . _:b421653619 . _:b421652780 . _:b421653620 . _:b421653621 . _:b421653622 . _:b421652612 "2"^^ . . _:b421653623 . _:b421652783 . _:b421653608 . . _:b421653609 . _:b421652958 . _:b421653610 . _:b421652615 "2"^^ . _:b421653611 . _:b421652782 . _:b421653612 . . _:b421653613 . _:b421653614 . _:b421652614 "2"^^ . _:b421653615 . _:b421652777 . . _:b421653600 . _:b421653601 . . _:b421653602 . _:b421652609 "2"^^ . . _:b421653603 . _:b421652776 . _:b421653604 . _:b421652225 . _:b421653605 . _:b421653606 . _:b421652608 "2"^^ . _:b421653607 . _:b421653280 . _:b421652779 . _:b421653592 . . _:b421653593 . _:b421653594 . _:b421652611 "2"^^ . _:b421653595 . _:b421652778 . _:b421653596 . . _:b421653597 . . _:b421653598 . _:b421652610 "2"^^ . . . _:b421653599 . _:b421653710 . _:b421652789 . _:b421653584 . _:b421653585 . . _:b421653586 . _:b421652621 "2"^^ . _:b421651918 . _:b421653587 . _:b421652788 . _:b421653588 . . . _:b421653589 . _:b421653590 . _:b421652620 "2"^^ . _:b421653591 . _:b421652791 . _:b421653576 . _:b421652269 . _:b421653577 . _:b421653578 . _:b421652623 "2"^^ . _:b421653579 . _:b421652790 . _:b421651556 . _:b421653580 . _:b421653581 . _:b421653582 . _:b421652622 "2"^^ . _:b421653583 . _:b421652785 . _:b421652576 . _:b421653568 . _:b421653569 . . _:b421653570 . _:b421652617 "2"^^ . . _:b421653571 . _:b421652784 . _:b421653572 . _:b421653573 . _:b421653574 . _:b421652616 "2"^^ . _:b421653575 . _:b421652787 . _:b421653560 . _:b421653561 . _:b421653562 . _:b421652619 "2"^^ . _:b421651757 . _:b421653563 . _:b421652786 . _:b421653564 . _:b421653565 . _:b421653566 . _:b421652618 "2"^^ . _:b421653567 . _:b421652797 . _:b421653552 . _:b421653553 . _:b421652555 . _:b421652046 . _:b421653554 . _:b421652629 "2"^^ . _:b421653555 . _:b421652796 . _:b421653556 . . _:b421653557 . _:b421653558 . _:b421652628 "2"^^ . _:b421653559 . _:b421652799 . _:b421651967 . _:b421653544 . _:b421653505 . _:b421653545 . _:b421653546 . _:b6691552 "between gene expression and DNA copy number for the MGES genes was determined using data from 76 high-grade gliomas for which both gene expression array and array comparative genomic hybridization (aCGH) profiling were performed>>4<<. Tumors were grouped based on molecular subtype (mesenchymal, proneural, or proliferative) and the mean expression for MGES genes were determined in each group." . _:b421652631 "2"^^ . . _:b421653547 . _:b421652798 . _:b421653548 . _:b421653336 . _:b421653549 . _:b421653550 . _:b421653596 . _:b421652755 . _:b421652630 "2"^^ . . _:b421653551 . _:b421652793 . . _:b421653536 . _:b421653537 . _:b421653538 . _:b421652625 "2"^^ . _:b421653539 . _:b421652792 . _:b421651995 . _:b421653540 . _:b421653541 . _:b421653542 . _:b421652624 "2"^^ . _:b421653543 . _:b421652795 . _:b421651705 . . _:b421653528 . _:b421652633 . _:b421653529 . _:b421653530 . _:b421652627 "2"^^ . _:b421653531 . _:b421652794 . _:b421653532 . _:b421653533 . _:b421653534 . _:b421652626 "2"^^ . . _:b421653535 . _:b421652805 . _:b421653520 . _:b421653521 . _:b421653522 . _:b421653284 . _:b421652637 "2"^^ . _:b421652041 . _:b421653523 . _:b421652804 . _:b421653524 . _:b421653525 . _:b421653526 . _:b421652636 "2"^^ . _:b421653527 . _:b421652807 . _:b421653512 . _:b421653761 . _:b421653513 . _:b421651910 . _:b421653514 . _:b421652639 "2"^^ . _:b421653515 . _:b421652806 . _:b421653516 . _:b421653419 . _:b421653517 . _:b421653518 . _:b421652638 "2"^^ . . . _:b421652801 . _:b421653519 . _:b421653504 . _:b421653505 . _:b421652015 . _:b421653506 . _:b421652633 "2"^^ . _:b421653507 . _:b421652800 . . _:b421653508 . _:b421653509 . _:b421651559 . . _:b421653510 . _:b421652632 "2"^^ . . _:b421653511 . _:b421652803 . . . . _:b421652440 . _:b421652635 "2"^^ . . _:b421652802 . _:b421652277 . . _:b421651698 . . _:b421652634 "2"^^ . _:b421652813 . . _:b421652645 "2"^^ . _:b421652305 . _:b421652165 . _:b421652812 . _:b421651877 . _:b421652644 "2"^^ . _:b421652815 . . _:b421652647 "2"^^ . . _:b421652814 . _:b421653685 . . _:b6691560 "ChIP was performed as described in Ref.>>47<<. SNB75 cell lysates were precleared with Protein A/G beads (Santa Cruz) and incubated at 4\u00B0C overnight with 1 \u00B5g of polyclonal antibody specific for C/EBP\u03B2 (sc-150, Santa Cruz), Stat3 (sc-482, Santa Cruz), FosL2 (Fra2, sc-604, Santa" . _:b421652646 "2"^^ . _:b421652809 . . _:b421652641 "2"^^ . _:b421652477 . _:b421652185 . _:b421652808 . . _:b421652640 "2"^^ . . _:b421651842 . _:b421651545 . _:b421652811 . _:b421652643 "2"^^ . _:b421652810 . _:b421651782 . _:b421652642 "2"^^ . _:b421652821 . _:b421652653 "2"^^ . . _:b421652820 . . _:b421652652 "2"^^ . _:b421652823 . _:b421652655 "2"^^ . _:b421652822 . _:b421652004 . _:b421652654 "2"^^ . _:b421652817 . . _:b421652431 . _:b421652649 "2"^^ . _:b421652816 . _:b421652648 "2"^^ . _:b421652577 . _:b421652819 . _:b421651740 . _:b421651606 . _:b421652651 "2"^^ . _:b421652818 . _:b421652650 "2"^^ . _:b6691587 "ARACNe predicted 92,660 transcriptional interactions, 1,217 of which were between TFs and 102 of 149 MGES genes>>4<<, represented across all the gene expression profile data." . _:b421652829 . _:b421652718 . _:b421652661 "2"^^ . _:b421652828 . _:b421651725 . _:b421652115 . _:b421652660 "2"^^ . _:b421652831 . . _:b421652663 "2"^^ . _:b421652830 . . . _:b421652662 "2"^^ . _:b421653251 . _:b421652825 . . _:b421652657 "2"^^ . _:b421652824 . . . _:b421652656 "2"^^ . _:b421653644 . _:b421652539 . _:b421652827 . . _:b421653069 . _:b421651925 . _:b421652659 "2"^^ . _:b421652826 . _:b421652658 "2"^^ . _:b421652837 . _:b421652669 "2"^^ . _:b421652836 . . _:b421653553 . _:b421651534 . _:b421651761 . _:b421652668 "2"^^ . _:b421652839 . _:b421652671 "2"^^ . _:b421652838 . _:b421652670 "2"^^ . _:b421652833 . _:b421652092 . _:b421652665 "2"^^ . _:b421653163 . . _:b421652832 . . . . _:b421652664 "2"^^ . _:b421652835 . _:b421653457 . _:b421652667 "2"^^ . _:b421652834 . _:b421652666 "2"^^ . _:b421652845 . _:b421652035 . _:b421652448 . _:b421652677 "2"^^ . _:b421651892 . _:b421652844 . . _:b421652676 "2"^^ . . . _:b421652847 . . _:b421652679 "2"^^ . _:b421652846 . _:b421652678 "2"^^ . _:b421652743 . _:b421652841 . _:b421652334 . _:b421652251 . _:b421652673 "2"^^ . _:b421652840 . _:b421652672 "2"^^ . _:b421651891 . _:b421652843 . . . _:b421652675 "2"^^ . _:b421652335 . _:b421652842 . _:b421652674 "2"^^ . _:b421652329 . _:b421652853 . _:b421652585 . . _:b421652685 "2"^^ . _:b421652852 . . _:b421652684 "2"^^ . _:b421652855 . . _:b421652687 "2"^^ . _:b421652854 . _:b421652686 "2"^^ . _:b421652849 . . . _:b421652681 "2"^^ . _:b421652848 . . _:b421652680 "2"^^ . _:b421652851 . _:b6691595 "The Atlas-TCGA dataset>>31<< includes 77 and 21 samples associated with worst- and best-prognosis, respectively (92 samples with intermediate prognosis were not considered)." . _:b421652683 "2"^^ . . _:b421652850 . _:b421652742 . _:b421652682 "2"^^ . _:b421653458 . _:b421652861 . . _:b421653669 . . _:b421652693 "2"^^ . . _:b421652860 . . _:b421653060 . _:b421652692 "2"^^ . _:b421652863 . . . _:b421652504 . _:b421651930 . . _:b421652695 "2"^^ . . _:b421652862 . _:b421652694 "2"^^ . _:b421652549 . _:b421652857 . _:b421652689 "2"^^ . _:b421653079 . _:b421652856 . _:b421653040 . . _:b421653145 . _:b421652688 "2"^^ . _:b421652859 . _:b421651803 . . _:b421652691 "2"^^ . _:b421652198 . _:b421652858 . . . _:b421652690 "2"^^ . _:b421652869 . _:b421652604 . . _:b421652701 "2"^^ . _:b421652868 . _:b421652003 . . _:b421652700 "2"^^ . . _:b421652871 . _:b421652703 "2"^^ . _:b421652870 . _:b421652702 "2"^^ . _:b421652865 . _:b421651855 . _:b421652455 . _:b421652697 "2"^^ . . _:b421652864 . _:b421652696 "2"^^ . _:b421652867 . _:b421652722 . _:b421652699 "2"^^ . _:b421652866 . _:b421653341 . _:b421652494 . _:b421652698 "2"^^ . _:b421653246 . _:b421652877 . _:b421652709 "2"^^ . _:b421652876 . _:b421652235 . _:b421652708 "2"^^ . _:b421652879 . _:b421652711 "2"^^ . _:b421652878 . . . _:b421653202 . _:b421651706 . _:b421651735 . _:b421652710 "2"^^ . _:b421652873 . _:b421651947 . _:b421652705 "2"^^ . _:b421652872 . _:b421652076 . _:b421652704 "2"^^ . _:b421652875 . _:b421652362 . _:b421652707 "2"^^ . _:b421652874 . _:b421651569 . _:b421652706 "2"^^ . _:b421652885 . _:b421652717 "2"^^ . _:b421652884 . _:b421652716 "2"^^ . _:b421652887 . _:b421652719 "2"^^ . _:b421651874 . _:b421652886 . _:b421653752 . _:b421653400 . _:b421652219 . _:b421652718 "2"^^ . _:b421652881 . . _:b421653335 . _:b421651871 . _:b421652713 "2"^^ . _:b421652880 . _:b421652712 "2"^^ . _:b421652883 . _:b421652715 "2"^^ . _:b421652762 . _:b421652882 . _:b421653594 . _:b421652714 "2"^^ . _:b421652893 . . _:b421652725 "2"^^ . . _:b421652892 . _:b421652112 . . _:b6691556 . . _:b421652724 "2"^^ . _:b421652309 . _:b421652385 . _:b421652895 . _:b421651744 . _:b6691557 . _:b421652540 . _:b421652727 "2"^^ . _:b421652894 . _:b421651611 . _:b421653714 . _:b421652726 "2"^^ . _:b421652889 . _:b421652721 "2"^^ . _:b421652888 . . _:b421652720 "2"^^ . . _:b421653521 . _:b421652891 . . _:b421651653 . _:b421652872 . _:b421652723 "2"^^ . . . _:b421652890 . . _:b421652722 "2"^^ . . _:b421652901 . . _:b421653075 . . . _:b421652733 "2"^^ . _:b421652900 . _:b421653009 . _:b421652732 "2"^^ . _:b421652903 . _:b6691589 . . _:b421652735 "2"^^ . _:b421652902 . _:b421652734 "2"^^ . _:b421652897 . _:b421652499 . _:b421652729 "2"^^ . _:b421651724 . _:b421652896 . _:b421652728 "2"^^ . _:b421652899 . _:b421652998 . _:b421652298 . _:b421652532 . . _:b421652731 "2"^^ . _:b421652898 . _:b421652074 . _:b421652730 "2"^^ . _:b421652155 . _:b421652909 . _:b421653027 . _:b421651796 . _:b421652741 "2"^^ . _:b421652908 . . _:b421652740 "2"^^ . _:b421652911 . . _:b421652743 "2"^^ . _:b421652910 . . _:b421652656 . _:b421652742 "2"^^ . _:b421651603 . _:b421652905 . . . _:b421652902 . _:b421652737 "2"^^ . _:b421652904 . _:b421653120 . _:b421652736 "2"^^ . _:b421652907 . . _:b421652739 "2"^^ . _:b421652906 . . _:b421652738 "2"^^ . . _:b421652917 . _:b421653754 . . . _:b421652749 "2"^^ . . . _:b421652916 . _:b421652402 . . _:b421653746 . _:b421652748 "2"^^ . _:b421651793 . _:b421652919 . . _:b421653756 . . _:b421652751 "2"^^ . _:b421651665 . _:b421652918 . . _:b421651581 . _:b421652750 "2"^^ . _:b421652423 . _:b421652913 . _:b421652745 "2"^^ . _:b421652912 . _:b421652744 "2"^^ . _:b421652915 . _:b421652747 "2"^^ . _:b421652914 . _:b421653104 . _:b421652746 "2"^^ . _:b421652925 . _:b421652757 "2"^^ . _:b421652924 . _:b421652756 "2"^^ . _:b421652927 . . _:b421652447 . . _:b421652759 "2"^^ . . _:b421652926 . . _:b421652758 "2"^^ . _:b421652921 . _:b421653211 . _:b421652753 "2"^^ . _:b421653306 . _:b421652920 . _:b421651731 . . _:b421652752 "2"^^ . _:b421652746 . _:b421652923 . _:b421652652 . _:b421652755 "2"^^ . _:b421652922 . _:b421653347 . . _:b421652754 "2"^^ . _:b421653437 . _:b421652933 . _:b421652765 "2"^^ . _:b421652932 . . _:b421652764 "2"^^ . . _:b421652935 . _:b421652767 "2"^^ . _:b421652934 . _:b421651648 . _:b421652766 "2"^^ . _:b421653092 . _:b421652159 . _:b421652929 . . _:b421651685 . _:b421652429 . _:b421652761 "2"^^ . _:b421652928 . . _:b421652760 "2"^^ . _:b421652931 . . . _:b421652763 "2"^^ . . _:b421652930 . . _:b421652762 "2"^^ . . _:b421652941 . _:b421653471 . . _:b421652195 . _:b421653465 . _:b421652773 "2"^^ . _:b421652940 . . _:b421652772 "2"^^ . . _:b421652943 . _:b421652775 "2"^^ . _:b421652942 . _:b421652774 "2"^^ . _:b421653623 . _:b421652937 . _:b421652327 . _:b421652769 "2"^^ . _:b421652936 . _:b421653598 . _:b421652768 "2"^^ . _:b421652939 . . _:b421653250 . _:b421652771 "2"^^ . _:b421652051 . . _:b421652938 . _:b421651869 . _:b421652770 "2"^^ . _:b421652949 . . _:b421652781 "2"^^ . _:b421652915 . _:b421652948 . _:b6691570 . . _:b421652780 "2"^^ . . _:b421652951 . _:b421651797 . . . . . _:b421652783 "2"^^ . _:b421652950 . . _:b421652782 "2"^^ . . _:b421652945 . . _:b421653296 . . _:b421652777 "2"^^ . _:b421652944 . _:b421653242 . _:b421653224 . _:b421653662 . . _:b421652985 . _:b421652776 "2"^^ . . _:b421652947 . . . . _:b421652779 "2"^^ . _:b421652946 . _:b421653753 . _:b421653355 . . . _:b421652778 "2"^^ . _:b421651883 . . _:b421652957 . _:b421651586 . . _:b421652789 "2"^^ . _:b421652956 . _:b421652788 "2"^^ . _:b421652959 . _:b421652791 "2"^^ . _:b421652958 . _:b421652805 . _:b421651879 . _:b421652790 "2"^^ . . _:b421652953 . _:b421652649 . _:b421652785 "2"^^ . . _:b421652952 . _:b421652528 . _:b421651622 . . _:b421652784 "2"^^ . _:b421653687 . . _:b421652955 . . _:b421652787 "2"^^ . . _:b421652954 . _:b421652786 "2"^^ . _:b421652965 . _:b421653760 . _:b421652797 "2"^^ . _:b421652130 . _:b421652964 . _:b421652796 "2"^^ . _:b421652967 . . _:b421652799 "2"^^ . _:b421652966 . _:b421653046 . _:b421652798 "2"^^ . _:b421652961 . _:b421652793 "2"^^ . . _:b421652960 . _:b421652034 . . _:b421652938 . . _:b421652792 "2"^^ . _:b421652963 . . . _:b421652795 "2"^^ . _:b421652962 . . _:b421652794 "2"^^ . . _:b421652973 . _:b421652805 "2"^^ . . _:b421652972 . . _:b421652804 "2"^^ . . _:b421652975 . . . _:b421652807 "2"^^ . _:b421652974 . . _:b421651570 . _:b421652806 "2"^^ . _:b421652969 . _:b421653292 . . . _:b421652801 "2"^^ . _:b421652546 . _:b421652968 . . . . _:b421652800 "2"^^ . _:b421652971 . . _:b421652803 "2"^^ . _:b421652970 . _:b421652802 "2"^^ . _:b421652981 . _:b421652080 . _:b6691558 "The log-transformation allows convenient linear representation of multiplicative interactions between TF activities44, >>45<<. TFs were individually added to the model, each time selecting the one contributing the most significant reduction in relative expression error (predicted vs. observed), until error-reduction was no longer significant." . _:b421652793 . . . _:b421652813 "2"^^ . _:b421652980 . _:b421653146 . _:b421653281 . _:b421652812 "2"^^ . _:b421652983 . _:b421652582 . _:b421652815 "2"^^ . _:b421651787 . _:b421652982 . _:b421652361 . _:b421652814 "2"^^ . _:b421652977 . . _:b421652809 "2"^^ . _:b421652976 . _:b421652808 "2"^^ . _:b421652979 . _:b421653455 . _:b421652811 "2"^^ . _:b421652978 . _:b421652810 "2"^^ . _:b421652989 . _:b421651539 . _:b421653581 . _:b421652821 "2"^^ . _:b421652946 . . _:b421652988 . _:b421652820 "2"^^ . _:b421653739 . _:b421652991 . _:b421652823 "2"^^ . _:b421652990 . . _:b421652822 "2"^^ . _:b421652985 . _:b421652817 "2"^^ . _:b421652984 . _:b421652816 "2"^^ . _:b421652987 . . _:b421652819 "2"^^ . _:b421653337 . _:b421652986 . _:b421652818 "2"^^ . _:b421652485 . _:b421652829 "2"^^ . _:b421653698 . _:b421652484 . _:b421651977 . . _:b421652828 "2"^^ . _:b421652487 . _:b421652831 "2"^^ . . _:b421652486 . _:b421652830 "2"^^ . _:b421653537 . _:b421653194 . . _:b421652481 . _:b421652825 "2"^^ . _:b421652390 . _:b421652480 . _:b421652824 "2"^^ . _:b421652483 . . _:b421653111 . _:b421652676 . _:b421652635 . _:b421652827 "2"^^ . _:b421652482 . _:b421652826 "2"^^ . _:b421651908 . _:b421652493 . _:b421652837 "2"^^ . _:b421652492 . . _:b421652857 . _:b421652836 "2"^^ . _:b421653392 . _:b421652495 . _:b421652839 "2"^^ . . _:b421652494 . _:b421653635 . _:b421652838 "2"^^ . _:b421652489 . _:b421652365 . _:b421652833 "2"^^ . _:b421652488 . _:b421652832 "2"^^ . _:b421652491 . _:b421651789 . . _:b421653000 . _:b421652835 "2"^^ . _:b421652490 . _:b421652061 . _:b421652164 . _:b421652485 . . _:b421652834 "2"^^ . . _:b421652501 . . _:b421652845 "2"^^ . _:b421652500 . . _:b421652703 . . _:b421652844 "2"^^ . _:b421652503 . . _:b421652847 "2"^^ . _:b421652502 . . . . _:b421653418 . _:b421652846 "2"^^ . _:b421652497 . . _:b421652260 . . _:b421652841 "2"^^ . _:b421652496 . . _:b421652840 "2"^^ . _:b421652499 . _:b421652843 "2"^^ . _:b421652498 . . _:b421652842 "2"^^ . . _:b421652509 . _:b421652853 "2"^^ . _:b421652508 . _:b421652243 . _:b421652852 "2"^^ . _:b421652511 . _:b421653634 . _:b421652855 "2"^^ . _:b421652510 . _:b421652854 "2"^^ . . _:b421652505 . . _:b421652849 "2"^^ . _:b421652504 . _:b421653570 . _:b421652848 "2"^^ . . _:b421652507 . _:b421651529 . _:b421652851 "2"^^ . _:b421652506 . _:b421652850 "2"^^ . _:b421652517 . _:b421652559 . _:b421652861 "2"^^ . _:b421652516 . _:b421652860 "2"^^ . _:b421652923 . _:b421652519 . . . _:b421652863 "2"^^ . _:b421652518 . _:b421652552 . _:b421651709 . _:b421652862 "2"^^ . _:b421653576 . _:b421652513 . . _:b421652535 . _:b421652579 . _:b421652857 "2"^^ . _:b421652512 . . _:b421652856 "2"^^ . . _:b421653555 . _:b421652515 . _:b421652859 "2"^^ . . _:b421652514 . _:b421652383 . _:b421652858 "2"^^ . . _:b421652525 . . _:b421651688 . _:b421652869 "2"^^ . . _:b421652524 . . . _:b421652482 . _:b421653631 . _:b421652868 "2"^^ . _:b421652527 . _:b421652871 "2"^^ . _:b6691559 "Primary mNSCs were isolated from E13.5 mouse telencephalon and cultured in the presence of FGF-2 and EGF (20 ng/ml each) as described>>42<<. Differentiation of NSCs was induced by culturing neurospheres on laminin-coated dishes in NSC medium in the absence of growth factors. mNSC expressing Stat3C and C/EBP\u03B2, were generated by retroviral infections using supernatant from" . _:b421652526 . _:b421653122 . . . _:b421652870 "2"^^ . _:b421652521 . _:b421653279 . . _:b421653678 . _:b421652865 "2"^^ . _:b421652520 . _:b421653247 . _:b421652864 "2"^^ . _:b421652523 . _:b421652867 "2"^^ . _:b421653697 . _:b421653357 . _:b421652522 . _:b421652866 "2"^^ . _:b421652533 . . _:b421652945 . _:b421652877 "2"^^ . _:b421653006 . _:b421652532 . _:b421652876 "2"^^ . _:b421652535 . . . . _:b421652879 "2"^^ . _:b421652534 . _:b421653291 . _:b421652878 "2"^^ . . _:b421652529 . _:b421652316 . _:b421652458 . _:b421652873 "2"^^ . _:b421652528 . . _:b421652872 "2"^^ . _:b421652531 . . _:b421653695 . . . _:b421652875 "2"^^ . _:b421652530 . _:b421652648 . _:b421652874 "2"^^ . _:b421652541 . . _:b421651655 . _:b421652885 "2"^^ . . _:b421652540 . _:b421652884 "2"^^ . _:b421652543 . _:b421652887 "2"^^ . _:b421652542 . _:b421651640 . _:b421652886 "2"^^ . . _:b421652537 . _:b421652881 "2"^^ . _:b421652536 . _:b421652830 . _:b421651651 . _:b421652880 "2"^^ . _:b421652539 . _:b421653721 . _:b421652883 "2"^^ . _:b421652119 . _:b421652538 . _:b421652882 "2"^^ . _:b421652549 . . _:b421652161 . _:b421652893 "2"^^ . _:b421652548 . _:b421652892 "2"^^ . _:b421652551 . . . _:b421652895 "2"^^ . . _:b421652734 . _:b421652550 . . . _:b421652894 "2"^^ . . _:b421652545 . . _:b421652111 . . _:b421652282 . _:b421652889 "2"^^ . _:b421652544 . _:b421652417 . _:b421652434 . _:b421652888 "2"^^ . _:b421652547 . _:b421652891 "2"^^ . _:b421652546 . _:b421652812 . _:b421653472 . _:b421652890 "2"^^ . _:b421652557 . . . _:b421652901 "2"^^ . _:b421652556 . _:b421651843 . _:b421653425 . _:b421651936 . _:b421652900 "2"^^ . . _:b421652559 . _:b421651656 . _:b421652903 "2"^^ . _:b421651628 . _:b421652558 . . . . _:b421653520 . _:b421652902 "2"^^ . _:b421652301 . _:b421652553 . . _:b421652636 . . _:b421652897 "2"^^ . _:b421652552 . _:b421652622 . _:b421652896 "2"^^ . _:b421652555 . _:b421652899 "2"^^ . _:b421652554 . . _:b421652898 "2"^^ . . _:b421652565 . _:b421652909 "2"^^ . _:b421652564 . _:b421652908 "2"^^ . _:b421652567 . . _:b421652911 "2"^^ . . _:b421652566 . _:b421653510 . _:b421652910 "2"^^ . _:b421652561 . . _:b421652905 "2"^^ . . _:b421652560 . _:b421653620 . _:b421652904 "2"^^ . . _:b421652563 . . . . _:b421652907 "2"^^ . . _:b421652562 . . _:b421652900 . _:b421652906 "2"^^ . _:b421652573 . . _:b421652917 "2"^^ . _:b421652572 . . _:b421652916 "2"^^ . _:b421653615 . . _:b421652575 . _:b421652919 "2"^^ . _:b421652574 . _:b421652637 . _:b421652918 "2"^^ . _:b421651807 . _:b421652569 . _:b421652913 "2"^^ . _:b421652568 . . _:b421653654 . _:b421651833 . _:b421652912 "2"^^ . _:b421652571 . . . _:b421652915 "2"^^ . _:b421651633 . _:b421652570 . _:b421652914 "2"^^ . _:b421652936 . . _:b421652581 . _:b421652505 . _:b421652601 . _:b421652925 "2"^^ . _:b421652580 . _:b421652924 "2"^^ . _:b421652179 . _:b421652583 . . _:b421652560 . . . _:b421653467 . _:b421652927 "2"^^ . . _:b421652582 . _:b421652926 "2"^^ . _:b421652042 . _:b421652577 . _:b421653215 . . . _:b421653248 . _:b421652921 "2"^^ . _:b421652716 . _:b421652576 . _:b421652920 "2"^^ . . _:b421652579 . _:b421652923 "2"^^ . _:b421652578 . . . _:b421652922 "2"^^ . . _:b421652589 . . _:b421653588 . _:b421652933 "2"^^ . _:b421652588 . _:b421652932 "2"^^ . _:b421652591 . _:b421652935 "2"^^ . _:b421651715 . _:b421652590 . _:b421653560 . _:b421652934 "2"^^ . _:b421652585 . . _:b421652929 "2"^^ . _:b421652584 . . _:b421652928 "2"^^ . _:b421652587 . _:b421652931 "2"^^ . _:b421652586 . . _:b421652930 "2"^^ . _:b421652597 . _:b421652941 "2"^^ . _:b421652596 . _:b421652283 . . _:b421652940 "2"^^ . . _:b421652599 . . _:b421653112 . _:b421652943 "2"^^ . . _:b421652598 . _:b421651773 . . . _:b421652942 "2"^^ . _:b421652593 . _:b421652937 "2"^^ . _:b421652592 . _:b421653665 . _:b421652936 "2"^^ . _:b421652595 . . _:b421652939 "2"^^ . _:b421652594 . _:b421653712 . . _:b421653062 .