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_:b544883508 . _:b544883509 . _:b544883510 . _:b544883511 . _:b544882888 . _:b544882889 . _:b544882890 . _:b544882891 . _:b544882812 "23"^^ . _:b544882892 . _:b544882893 . _:b544883368 . _:b544882894 . . _:b544882895 . _:b544882813 "22"^^ . _:b544883200 . _:b544882880 . _:b544882814 "19"^^ . _:b544882881 . _:b544882815 "17"^^ . _:b544883479 . _:b544882882 . _:b544882883 . . _:b544883577 . _:b544882884 . _:b544882885 . _:b544882816 "17"^^ . _:b544882886 . . _:b544882887 . _:b544883217 . _:b544882904 . . _:b544882905 . _:b544882817 "16"^^ . _:b544882971 . _:b544882906 . _:b544882907 . _:b544882908 . _:b544882818 "16"^^ . _:b544882909 . _:b544882910 . _:b544882911 . _:b544882819 "15"^^ . _:b544882896 . _:b544882897 . _:b544882898 . _:b544882899 . . _:b544882900 . _:b544882820 "15"^^ . . _:b544882901 . _:b544882902 . _:b544882821 "14"^^ . _:b544882903 . . _:b544882920 . _:b544882921 . _:b544882922 . _:b544882875 . _:b544882923 . _:b544882822 "14"^^ . _:b544882924 . _:b544882925 . _:b544882926 . _:b544882823 "14"^^ . _:b544882927 . . _:b544882912 . . _:b544882913 . _:b544882914 . _:b544882915 . _:b544883449 . _:b544882831 "11"^^ . _:b544882916 . _:b544882917 . _:b544882918 . _:b544882919 . _:b544882830 "11"^^ . _:b544883566 . _:b544882936 . . _:b544882937 . _:b544882938 . _:b544883139 . _:b544882939 . _:b544882829 "11"^^ . _:b544882940 . _:b544882941 . _:b544882942 . _:b544883349 . _:b544882943 . _:b544882828 "11"^^ . _:b544883499 . _:b544882928 . _:b544882929 . _:b544883061 . _:b544882930 . _:b544882931 . _:b544882932 . _:b544882827 "12"^^ . _:b544882933 . _:b544882934 . _:b544882935 . _:b544882824 . . _:b544882825 . _:b544882826 "12"^^ . . _:b544883276 . _:b544882826 . _:b544882827 . . _:b544883197 . _:b544882828 . _:b544882829 . _:b544882825 "13"^^ . _:b544882830 . _:b544882831 . _:b544882816 . _:b544882817 . . _:b544882818 . _:b544882824 "13"^^ . _:b544882819 . _:b544882820 . . _:b544882821 . _:b544882838 "9"^^ . _:b544882822 . _:b544882823 . _:b544882840 . . _:b544882841 . _:b544882839 "9"^^ . _:b544882842 . _:b544882843 . _:b544882844 . _:b544882845 . _:b544882836 "9"^^ . _:b544882846 . _:b544882847 . _:b544882832 . . _:b544882833 . _:b544882837 "9"^^ . _:b544882834 . _:b544882835 "10"^^ . _:b544882835 . _:b544882878 . _:b544882836 . _:b544882837 . _:b544882838 . _:b544883564 . _:b544882834 "10"^^ . _:b544882839 . _:b544882856 . _:b544882857 . _:b544883282 . _:b544883188 . _:b544882858 . _:b544882833 "10"^^ . _:b544882859 . . _:b544882860 . _:b544882861 . _:b544882862 . _:b544882832 "10"^^ . _:b544882863 . _:b544882848 . _:b544882849 . _:b544883423 . _:b544882850 . _:b544882851 . _:b544882852 . _:b544882846 "8"^^ . _:b544882853 . _:b544882854 . _:b544882855 . _:b544882872 . _:b544882847 "8"^^ . _:b544882873 . _:b544882874 . _:b544882875 . _:b544882876 . _:b544882844 "8"^^ . _:b544882877 . _:b544882878 . _:b544882879 . _:b544882864 . _:b544882845 "8"^^ . _:b544882865 . . _:b544882866 . _:b544882867 . _:b544882868 . _:b544882869 . . _:b544882870 . _:b544882842 "9"^^ . _:b544882871 . _:b544882843 "8"^^ . _:b544883033 . _:b544882840 "9"^^ . . _:b28799532 "To obtain R26R-Confetti; Lgr5-EGFP-Ires-CreERT2 mice, R26R-Confetti7 mice were crossed with Lgr5-EGFP-Ires-CreERT>>21<<. Random double heterozygous male mice between 10-22 weeks old were used for experiments. Three days before imaging, mice were injected with 2.5-5 mg Tamoxifen (single injection; Sigma Aldrich) to induce activation of Cre recombinase to" . _:b544882841 "9"^^ . _:b544882854 "8"^^ . _:b544882990 . . _:b544882855 "8"^^ . . _:b544883148 . . _:b544882852 "8"^^ . _:b544882853 "8"^^ . _:b544882939 . . _:b544882850 "8"^^ . . _:b544882851 "8"^^ . . . _:b544882848 "8"^^ . . _:b544882849 "8"^^ . _:b544882862 "7"^^ . _:b544883205 . . _:b544882808 . . _:b544882863 "7"^^ . _:b544883204 . _:b544882809 . _:b544882810 . _:b544882811 . _:b544882860 "7"^^ . _:b544883591 . _:b544882812 . _:b544883207 . _:b544882813 . _:b544882814 . _:b544882815 . _:b544882861 "7"^^ . . _:b544883206 . _:b544883170 . _:b544882858 "7"^^ . . _:b544883201 . _:b544883582 . . _:b544882807 . _:b544882859 "7"^^ . . _:b544883200 . . _:b544883203 . _:b544882856 "8"^^ . _:b544883202 . _:b544882857 "8"^^ . _:b544882870 "7"^^ . _:b544883213 . . _:b544882871 "7"^^ . _:b544883212 . _:b544882868 "7"^^ . _:b544883215 . _:b544883124 . _:b544882869 "7"^^ . _:b544883214 . . . _:b544883544 . _:b544882872 . _:b544882866 "7"^^ . _:b544883209 . _:b544883084 . _:b544882867 "7"^^ . _:b544883208 . _:b544883221 . _:b544882864 "7"^^ . _:b544883211 . . _:b544882865 "7"^^ . _:b544883210 . _:b544882878 "6"^^ . _:b544883221 . _:b544882879 "6"^^ . . _:b544883220 . . _:b544882876 "6"^^ . . _:b544883223 . _:b544882877 "6"^^ . _:b544883222 . _:b544882874 "7"^^ . _:b28799526 . _:b544883217 . . _:b544882875 "6"^^ . _:b544883144 . _:b28799527 . . _:b544883145 . _:b544883216 . _:b544883146 . _:b544883147 . . _:b544883148 . _:b544882872 "7"^^ . . _:b544883584 . _:b544883319 . _:b544883149 . _:b544883219 . _:b544882832 . _:b544883150 . _:b544883016 . _:b544883151 . _:b544882873 "7"^^ . _:b544883136 . _:b544883218 . _:b544883363 . _:b544883137 . _:b544883138 . _:b544882886 "6"^^ . _:b544883139 . _:b544883140 . _:b544883229 . _:b544883141 . _:b544882948 . _:b544883142 . _:b544882887 "6"^^ . _:b544883143 . . _:b544883160 . . _:b544883161 . _:b544883228 . _:b544883162 . _:b544882884 "6"^^ . _:b544883163 . _:b544883164 . _:b28799532 . _:b544883231 . _:b544882987 . _:b544883165 . _:b544883162 . _:b544883166 . _:b544882885 "6"^^ . _:b544883167 . _:b544883152 . _:b544883230 . _:b544883153 . _:b544883154 . _:b544882882 "6"^^ . _:b544883155 . _:b544883156 . . _:b544883312 . _:b544883157 . _:b544883225 . _:b544883158 . _:b544882883 "6"^^ . _:b544883159 . _:b544883176 . _:b544883224 . _:b544883177 . _:b544883178 . _:b544882880 "6"^^ . _:b544883179 . _:b544883180 . _:b28799528 . _:b544883227 . _:b544883181 . _:b544883137 . _:b544883182 . _:b544882881 "6"^^ . _:b544883183 . . _:b28799529 . _:b544883168 . _:b544883226 . _:b544883169 . _:b544883170 . _:b544883171 . . _:b544883172 . _:b544883069 . _:b28799530 . _:b544883173 . _:b544883237 . _:b544882893 "5"^^ . _:b544883174 . . _:b544883175 . _:b544883192 . _:b28799531 . _:b544883236 . _:b544883193 . _:b544882892 "5"^^ . _:b544883194 . _:b544883195 . _:b544883196 . _:b544883589 . _:b544883239 . _:b544883197 . _:b544882895 "5"^^ . _:b544883198 . . _:b544883199 . _:b544883132 . _:b544883184 . _:b544883370 . _:b544883238 . _:b544883185 . . _:b544883186 . _:b544882894 "5"^^ . _:b544883187 . _:b544883188 . _:b544883397 . _:b544883233 . _:b544883189 . _:b544882889 "5"^^ . _:b544883190 . _:b544882989 . _:b544883191 . _:b544883080 . _:b544883232 . _:b544883321 . _:b544883081 . . _:b544882888 "5"^^ . _:b544883082 . . _:b544883083 . . _:b544883084 . _:b544883085 . . _:b544883235 . _:b544883086 . _:b544882891 "5"^^ . _:b544883087 . _:b544883072 . _:b544883073 . _:b544883234 . _:b544883074 . _:b544882890 "5"^^ . _:b544883075 . _:b544883076 . _:b544883077 . _:b544883245 . _:b544883078 . _:b544882901 "5"^^ . _:b544883079 . _:b544883096 . _:b544883097 . _:b544883244 . _:b544883098 . _:b544882900 "5"^^ . _:b544883099 . _:b544883100 . . _:b544883101 . _:b544883247 . _:b544883102 . _:b544882903 "5"^^ . _:b544883103 . _:b544883088 . . _:b544883089 . _:b544883246 . _:b544883090 . _:b544882902 "5"^^ . _:b544883091 . _:b544883092 . _:b544883093 . . _:b544883241 . _:b544883094 . _:b544883332 . _:b544882897 "5"^^ . . . _:b544883095 . _:b544883112 . _:b544883113 . _:b544883240 . _:b544883114 . _:b544882896 "5"^^ . _:b544883115 . _:b544883116 . _:b544883117 . _:b544883243 . _:b544883118 . _:b544882899 "5"^^ . _:b544883119 . . _:b544883104 . _:b544883105 . _:b544883242 . _:b544883227 . _:b544883106 . _:b544882898 "5"^^ . _:b544883107 . _:b544883108 . _:b544883109 . _:b544883253 . _:b544883110 . _:b544882909 "5"^^ . _:b544883111 . _:b544883128 . . _:b544883129 . _:b544883252 . . _:b544883130 . _:b544882908 "5"^^ . _:b544883131 . . _:b544883132 . _:b544883181 . . _:b544883133 . _:b544883255 . _:b544883134 . _:b544882911 "5"^^ . _:b544883135 . _:b544883120 . _:b544883121 . _:b544883254 . . _:b544883122 . _:b544882910 "5"^^ . _:b544883079 . . _:b544883123 . _:b544883325 . _:b544883124 . _:b544883253 . . _:b544883125 . _:b544883111 . _:b544883249 . _:b544883126 . _:b544882905 "5"^^ . _:b544883127 . _:b544883016 . _:b544883017 . _:b544883248 . _:b544883018 . _:b544882904 "5"^^ . _:b544883019 . . _:b544883020 . . . _:b544883021 . _:b544883251 . _:b544883022 . _:b544882907 "5"^^ . _:b544883023 . _:b544883008 . _:b544883009 . _:b544883526 . _:b544883250 . _:b544883010 . _:b544882906 "5"^^ . _:b544883011 . _:b544883159 . _:b544883012 . _:b544882944 . _:b544883013 . _:b544883261 . _:b544883014 . _:b544882917 "5"^^ . . _:b544883015 . _:b544882827 . _:b544883032 . _:b544883517 . _:b544883357 . _:b544883033 . _:b544883260 . _:b544883034 . _:b544882916 "5"^^ . _:b544883035 . _:b544883036 . _:b544883434 . _:b544882855 . _:b544883037 . _:b544883263 . _:b544883038 . _:b544883485 . _:b544882919 "5"^^ . _:b544883039 . _:b544883024 . . _:b544883025 . _:b544883262 . _:b544883026 . _:b544882918 "5"^^ . . _:b544883027 . _:b544883028 . . _:b544883257 . . _:b544883029 . _:b544883030 . _:b544882913 "5"^^ . _:b544883031 . _:b544883048 . _:b544883049 . _:b544883256 . _:b544882808 . _:b544883050 . _:b544882912 "5"^^ . _:b544883051 . _:b544883432 . _:b544883052 . _:b544883053 . _:b544883259 . _:b544883054 . _:b544882915 "5"^^ . _:b544883055 . . _:b544883040 . . _:b544883041 . _:b544883258 . _:b544883042 . _:b544882914 "5"^^ . _:b544883043 . _:b544883044 . _:b544883045 . _:b544883269 . _:b544883046 . _:b544882925 "5"^^ . . _:b544883047 . _:b544883064 . _:b544883065 . _:b544883268 . _:b544883066 . _:b544882924 "5"^^ . _:b544883067 . _:b544883068 . _:b544883069 . _:b544883271 . _:b544882938 . _:b544883070 . _:b544882927 "5"^^ . _:b544883071 . _:b544883056 . _:b544883057 . _:b544883270 . _:b544883058 . _:b544882926 "5"^^ . _:b544883059 . _:b544883060 . . _:b544883061 . _:b544883265 . _:b544883062 . _:b544882921 "5"^^ . _:b544883063 . _:b544883211 . _:b544882952 . _:b544883547 . _:b544882953 . _:b544883264 . _:b544882954 . _:b544882920 "5"^^ . _:b544882955 . _:b544883311 . . _:b544882956 . _:b544882921 . _:b544883267 . _:b544882957 . _:b544882958 . _:b544882923 "5"^^ . . _:b544882959 . _:b544882944 . _:b544882945 . _:b544883266 . _:b544882946 . _:b544882922 "5"^^ . _:b544882947 . _:b544882948 . _:b544882949 . _:b544883277 . _:b544882950 . _:b544882933 "5"^^ . _:b544882951 . _:b544883272 . _:b544882968 . _:b544882969 . _:b544883276 . _:b544882970 . _:b544883270 . _:b544882932 "5"^^ . _:b544882971 . _:b544882972 . _:b544882953 . _:b544883046 . _:b544882973 . _:b544883279 . _:b544882974 . _:b544882935 "5"^^ . _:b544882955 . _:b544882975 . _:b544882960 . _:b544882961 . _:b544883278 . _:b544883093 . _:b544882962 . _:b544882934 "5"^^ . _:b544882963 . _:b544882964 . _:b544882965 . _:b544883273 . . _:b544882966 . _:b544882929 "5"^^ . . _:b544882967 . _:b544882984 . _:b544882985 . _:b544883272 . _:b544882986 . _:b544882928 "5"^^ . _:b544882987 . _:b544882988 . _:b544882989 . _:b544883275 . _:b544882990 . _:b544882931 "5"^^ . _:b544882991 . _:b544882932 . _:b544882976 . . _:b544882977 . _:b544883274 . _:b544882978 . _:b544882930 "5"^^ . _:b544882979 . _:b544882980 . _:b544882883 . _:b544882981 . _:b544883445 . _:b544883285 . _:b544882941 "4"^^ . _:b544882982 . . _:b544882983 . _:b544883000 . _:b544883001 . _:b544883284 . _:b544882940 "4"^^ . _:b544883002 . _:b544883003 . _:b544883004 . _:b544883005 . _:b544883287 . _:b544882943 "4"^^ . _:b544883006 . _:b544883007 . _:b544882992 . _:b544882993 . _:b544883286 . _:b544882942 "4"^^ . _:b544882994 . _:b544882995 . _:b544883203 . _:b544882996 . _:b544882997 . _:b28799527 . _:b544883281 . _:b544882937 "4"^^ . _:b544882998 . _:b544882999 . _:b544883280 . _:b544882936 "5"^^ . _:b544882939 "4"^^ . _:b544883283 . _:b544882938 "4"^^ . _:b544883282 . . _:b544883293 . . _:b544882949 "4"^^ . _:b544883602 . _:b544882948 "4"^^ . _:b544883292 . _:b544883108 . _:b544882951 "4"^^ . _:b544883295 . . _:b544882968 . _:b544883018 . _:b544883294 . _:b544882950 "4"^^ . _:b544882945 "4"^^ . _:b544883346 . _:b544883289 . _:b544883125 . _:b544882944 "4"^^ . _:b544883288 . _:b544883087 . . _:b544883291 . _:b544882947 "4"^^ . _:b544883007 . . . . _:b544882946 "4"^^ . _:b544883290 . . _:b544882814 . . _:b28799531 . _:b544883301 . _:b544882957 "4"^^ . . _:b544883229 . _:b544883300 . _:b544882956 "4"^^ . _:b544882959 "4"^^ . _:b544883303 . . . _:b544882958 "4"^^ . _:b544883302 . _:b544883176 . _:b544883297 . _:b544882953 "4"^^ . . . _:b544882952 "4"^^ . _:b544883296 . . _:b544882955 "4"^^ . _:b544883299 . . _:b544882954 "4"^^ . _:b544883298 . _:b544882965 "4"^^ . _:b544883309 . _:b544882964 "4"^^ . _:b544883308 . . _:b544882967 "4"^^ . _:b544883311 . . _:b544882966 "4"^^ . _:b544883310 . . _:b544883305 . _:b544883280 . _:b544882961 "4"^^ . _:b544882960 "4"^^ . _:b544883304 . _:b544882963 "4"^^ . _:b544883307 . _:b544883223 . _:b544882962 "4"^^ . _:b544883306 . _:b544882973 "4"^^ . _:b544883317 . . _:b544882972 "4"^^ . _:b544883316 . . . _:b544883538 . _:b544882975 "4"^^ . _:b544883319 . . _:b544882974 "4"^^ . _:b544883541 . _:b544883318 . _:b544883247 . . _:b544883562 . _:b544883421 . _:b544882969 "4"^^ . _:b544883313 . _:b544882863 . _:b544882968 "4"^^ . _:b544883312 . _:b544882971 "4"^^ . _:b544883315 . . . _:b544883315 . _:b544882970 "4"^^ . _:b544883314 . . _:b544882981 "4"^^ . _:b544883325 . . _:b544882980 "4"^^ . _:b544883324 . _:b544883458 . . . _:b544882983 "4"^^ . _:b544883327 . _:b544882982 "4"^^ . _:b544883326 . _:b544883123 . _:b544882977 "4"^^ . _:b544883321 . _:b544882976 "4"^^ . _:b544883320 . _:b544883275 . _:b544882979 "4"^^ . _:b544883323 . _:b544882978 "4"^^ . _:b544883322 . _:b544882989 "4"^^ . _:b544883354 . _:b544883333 . _:b544882988 "4"^^ . _:b544883332 . . _:b544882951 . _:b544882991 "4"^^ . _:b544883335 . _:b544882990 "4"^^ . _:b544883334 . . _:b544882985 "4"^^ . _:b544883329 . _:b544882984 "4"^^ . _:b544883328 . . _:b544883480 . _:b544883546 . _:b544882987 "4"^^ . _:b544883331 . _:b544882922 . _:b544882986 "4"^^ . _:b544883330 . _:b544882997 "4"^^ . _:b544883341 . _:b544882996 "4"^^ . _:b544883340 . _:b544883179 . . _:b544882866 . _:b544882970 . _:b544882999 "4"^^ . _:b544883343 . . . _:b544882998 "4"^^ . _:b544883342 . . . _:b544882993 "4"^^ . _:b544883337 . _:b544883047 . . _:b544882992 "4"^^ . _:b544883336 . _:b544883136 . _:b544882995 "4"^^ . _:b544883339 . _:b544883127 . _:b544882994 "4"^^ . _:b544883338 . _:b544883005 "3"^^ . _:b544883349 . _:b544883220 . _:b544883004 "3"^^ . _:b544883348 . _:b544883007 "3"^^ . _:b544883351 . . _:b544882956 . _:b544882999 . _:b544883006 "3"^^ . _:b544883350 . . _:b544883001 "4"^^ . _:b544883345 . _:b544882861 . . _:b544883000 "4"^^ . _:b544883344 . _:b544883003 "3"^^ . . _:b544883347 . _:b544883593 . _:b544883487 . _:b544883002 "3"^^ . _:b544883346 . _:b544883013 "3"^^ . _:b544883357 . _:b544883012 "3"^^ . _:b544883356 . _:b544883015 "3"^^ . _:b544883359 . _:b544883014 "3"^^ . . _:b544883358 . _:b544883062 . _:b544883009 "3"^^ . . _:b544883353 . _:b544883460 . _:b544883008 "3"^^ . _:b544883352 . _:b544883011 "3"^^ . _:b544883355 . . _:b544883010 "3"^^ . _:b544883028 . _:b544883354 . _:b544883021 "3"^^ . _:b544883342 . _:b544883365 . _:b544883568 . _:b544883020 "3"^^ . _:b544883364 . _:b544883023 "3"^^ . _:b544883367 . _:b544883309 . _:b544883022 "3"^^ . _:b544883100 . _:b544883366 . _:b544883017 "3"^^ . _:b544883560 . _:b544883361 . _:b544883016 "3"^^ . _:b544883398 . _:b544883360 . . . . _:b544883019 "3"^^ . _:b544883363 . . _:b544882961 . _:b544882942 . _:b544883018 "3"^^ . _:b544883362 . _:b544883147 . _:b544883029 "3"^^ . _:b544882963 . _:b544883373 . _:b544883028 "3"^^ . . _:b544883372 . _:b544882877 . _:b544883031 "3"^^ . _:b544882831 . _:b544883375 . _:b544883437 . _:b544883440 . _:b544883030 "3"^^ . _:b544883251 . _:b544883374 . . . _:b544883025 "3"^^ . _:b544883369 . _:b544883024 "3"^^ . _:b544883368 . . _:b544883027 "3"^^ . _:b544883371 . _:b544883026 "3"^^ . _:b544883370 . _:b544883174 . _:b544883037 "3"^^ . . _:b544883381 . _:b544883036 "3"^^ . . . _:b544883380 . . _:b544882888 . _:b544883175 . _:b544883039 "3"^^ . _:b544883383 . _:b544883038 "3"^^ . _:b544882977 . _:b544883382 . . _:b544883033 "3"^^ . _:b544883206 . _:b544883377 . _:b544883032 "3"^^ . . _:b544883376 . _:b544883035 "3"^^ . _:b544883379 . _:b544882886 . _:b544883034 "3"^^ . _:b544883011 . _:b544883378 . _:b544883045 "3"^^ . . . _:b544883389 . _:b544883264 . _:b544883044 "3"^^ . _:b544883388 . _:b544883047 "3"^^ . _:b544883391 . _:b544883494 . _:b544883026 . _:b544883046 "3"^^ . . _:b544883390 . _:b544883041 "3"^^ . _:b544883385 . _:b544883040 "3"^^ . _:b544883384 . _:b544883482 . _:b544883043 "3"^^ . _:b544883076 . _:b544883387 . . _:b544883042 "3"^^ . _:b544883386 . _:b544883496 . _:b544883053 "3"^^ . _:b544883397 . _:b544883052 "3"^^ . . _:b544883396 . _:b544883232 . _:b544883055 "3"^^ . _:b544883399 . _:b28799527 "The bars reproduce the findings of a fixed clonal assay using the same Lgr5-Confetti mouse construct used in the present study and first presented in Ref. [>>7<<]. Error bars denote SEM." . . . _:b544883054 "3"^^ . _:b544883398 . _:b544883404 . . _:b544883362 . _:b544883049 "3"^^ . _:b544883310 . _:b544883393 . _:b544882943 . _:b544883048 "3"^^ . _:b544883392 . . _:b544882973 . _:b544883442 . _:b544883051 "3"^^ . _:b544883395 . _:b544883050 "3"^^ . _:b544883394 . . _:b544883061 "3"^^ . _:b544883323 . _:b544883405 . _:b544882893 . _:b544883238 . _:b544883060 "3"^^ . . _:b544882843 . _:b544883404 . . _:b544883063 "3"^^ . . _:b544883407 . _:b544883062 "3"^^ . . _:b544883406 . _:b544883411 . _:b544883057 "3"^^ . _:b544883401 . _:b544883056 "3"^^ . _:b544883400 . _:b544883059 "3"^^ . _:b544883403 . _:b544883417 . _:b544883058 "3"^^ . _:b544883126 . _:b544883402 . _:b544882917 . _:b544883069 "3"^^ . _:b544883413 . _:b544883523 . _:b544883068 "3"^^ . _:b544883412 . . _:b544883452 . . _:b544883071 "3"^^ . _:b544883006 . _:b544883415 . . . _:b544883070 "3"^^ . . _:b544882988 . _:b544883414 . _:b544883596 . _:b544883065 "3"^^ . . _:b544883409 . . _:b544883064 "3"^^ . _:b544883408 . _:b544883262 . _:b544883067 "3"^^ . _:b544883411 . . _:b544883066 "3"^^ . _:b544883410 . _:b544883077 "3"^^ . _:b544883348 . . _:b544883421 . _:b544883076 "3"^^ . _:b544883420 . _:b544883429 . _:b544882895 . _:b544883079 "3"^^ . _:b544883423 . _:b544883078 "3"^^ . _:b544883422 . _:b544883073 "3"^^ . . _:b544883417 . . _:b544883072 "3"^^ . . _:b544883416 . . _:b544883075 "3"^^ . _:b544883419 . _:b544883356 . _:b544883074 "3"^^ . _:b544883418 . _:b544883472 . _:b544883085 "3"^^ . _:b544883429 . _:b544883084 "3"^^ . _:b544883428 . _:b544883071 . _:b544883087 "3"^^ . _:b544883431 . . _:b544883086 "3"^^ . . _:b544883430 . _:b544883081 "3"^^ . . _:b544883032 . _:b544883425 . _:b544883080 "3"^^ . . _:b544883424 . . . . _:b544883083 "3"^^ . _:b544883427 . _:b544882936 . _:b544883082 "3"^^ . . _:b544883426 . _:b544883004 . _:b544883578 . _:b544883093 "3"^^ . _:b544883437 . _:b544883092 "3"^^ . _:b544883461 . _:b544883426 . _:b544883436 . _:b544883003 . _:b544883095 "3"^^ . . . _:b544883439 . _:b544883094 "3"^^ . . _:b544883438 . _:b544883089 "3"^^ . _:b544883433 . _:b544883088 "3"^^ . _:b544883432 . _:b544883091 "3"^^ . _:b544883435 . _:b544883090 "3"^^ . . . _:b544883434 . . _:b544883101 "3"^^ . _:b544883445 . _:b544883100 "3"^^ . _:b28799530 . _:b544883444 . _:b544883103 "3"^^ . _:b544883447 . . _:b544883102 "3"^^ . . _:b544883446 . _:b544883097 "3"^^ . _:b28799526 . _:b544883441 . _:b544883535 . _:b544883096 "3"^^ . _:b544883440 . . _:b544883405 . _:b544883099 "3"^^ . _:b544883443 . _:b544882815 . . _:b544883098 "3"^^ . _:b544883442 . _:b544883109 "3"^^ . _:b544883453 . . _:b544883108 "3"^^ . _:b544883452 . _:b544883111 "3"^^ . . _:b544883455 . . _:b544883543 . _:b544883110 "3"^^ . _:b544883454 . . _:b544883105 "3"^^ . _:b544883449 . _:b544883501 . _:b544883104 "3"^^ . . _:b544883448 . _:b544883107 "3"^^ . . . _:b544883451 . . _:b544883539 . _:b544883106 "3"^^ . _:b544882834 . _:b544883471 . _:b544883450 . _:b544883117 "3"^^ . . _:b544882949 . _:b544883168 . _:b544883116 "3"^^ . _:b544882838 . _:b544883152 . _:b544882948 . _:b544883119 "3"^^ . _:b544882951 . _:b544883118 "3"^^ . _:b544882950 . _:b544883113 "3"^^ . _:b544882945 . _:b544883112 "3"^^ . _:b544882944 . _:b544883115 "3"^^ . _:b544882947 . _:b544883114 "3"^^ . _:b544882946 . _:b544883576 . _:b544883125 "3"^^ . _:b544882957 . . . . . _:b544883124 "3"^^ . _:b544882956 . _:b544883403 . _:b544883127 "3"^^ . _:b544882959 . _:b544883126 "3"^^ . _:b544882958 . . _:b544883121 "3"^^ . _:b544882953 . _:b544883112 . _:b544883120 "3"^^ . _:b544882952 . _:b544883350 . _:b28799529 "these parameters translate to the ratio \u03BBpcc/Nstem2 =0.026 per week, very close to the figure of 0.025 per week obtained from a fit of the measured monoclonal crypt fraction to the one-dimensional neutral drift dynamics model in Ref. [>>8<<]. (For the labeling protocol and the experimental data points, we refer to the original reference)." . _:b544883123 "3"^^ . _:b544882955 . _:b544883122 "3"^^ . _:b544882852 . _:b544882954 . _:b544883507 . _:b544883366 . _:b544883133 "3"^^ . _:b544882965 . _:b544882892 . . _:b544883132 "3"^^ . _:b544883525 . _:b544882964 . . _:b544883135 "3"^^ . _:b544882967 . . _:b544883134 "3"^^ . _:b544883466 . _:b544882966 . _:b544883129 "3"^^ . _:b544882961 . _:b544883384 . _:b544883128 "3"^^ . _:b544882960 . _:b544883131 "3"^^ . _:b544882963 . . _:b544883130 "3"^^ . _:b544882962 . _:b544883600 . _:b544883141 "2"^^ . _:b544883610 . _:b544882973 . . _:b544883140 "2"^^ . . _:b544882972 . . . . _:b544883143 "2"^^ . _:b544882975 . "10.1038%2Fnature12972" . . _:b544883468 . _:b544883457 . _:b544883142 "2"^^ . _:b544882974 . _:b544883137 "3"^^ . _:b544882969 . _:b544883390 . _:b544883518 . _:b544883136 "3"^^ . _:b544882968 . . _:b544883433 . _:b544883139 "2"^^ . _:b544882971 . . _:b544883138 "3"^^ . _:b544882970 . _:b544883149 "2"^^ . _:b544883375 . _:b544882981 . _:b544883148 "2"^^ . . _:b544882980 . _:b544883151 "2"^^ . _:b544883554 . _:b544883151 . _:b544882839 . _:b544882983 . _:b544883150 "2"^^ . _:b544882982 . _:b544883145 "2"^^ . _:b544882977 . . _:b544883261 . _:b544883395 . _:b544883144 "2"^^ . . _:b544882976 . _:b544883540 . _:b544883147 "2"^^ . _:b544883300 . _:b544882979 . _:b544883146 "2"^^ . _:b544882978 . _:b544882819 . _:b544883157 "2"^^ . _:b544882989 . _:b544883155 . _:b544883156 "2"^^ . . _:b544882894 . _:b544882988 . _:b544883159 "2"^^ . _:b544882825 . _:b544883465 . _:b544882991 . . _:b544883570 . _:b544883158 "2"^^ . _:b544882976 . _:b544883192 . _:b544883450 . _:b544882990 . . _:b544883153 "2"^^ . _:b544882985 . _:b544882826 . _:b544883152 "2"^^ . _:b544882984 . _:b544883155 "2"^^ . . _:b544882987 . _:b544883154 "2"^^ . _:b544882986 . _:b544883555 . _:b544883165 "2"^^ . . _:b544882997 . _:b544882997 . _:b544883164 "2"^^ . . . _:b544883027 . _:b544882996 . . _:b544882837 . _:b544883167 "2"^^ . _:b544882999 . . _:b544883166 "2"^^ . _:b544882998 . _:b544883149 . _:b544883161 "2"^^ . _:b544882993 . . _:b544883160 "2"^^ . . . _:b544882992 . _:b544883163 "2"^^ . _:b544882995 . _:b544883162 "2"^^ . . _:b544882994 . . _:b544883173 "2"^^ . . _:b544883005 . _:b544883172 "2"^^ . _:b544883483 . . _:b544883004 . . _:b544882848 . _:b544883175 "2"^^ . _:b544883598 . _:b544883007 . _:b544883174 "2"^^ . _:b544883006 . . _:b544883169 "2"^^ . _:b544883001 . _:b544883168 "2"^^ . . _:b544883000 . _:b544883171 "2"^^ . . . _:b544883259 . _:b544883003 . _:b544883579 . _:b544883195 . _:b544883170 "2"^^ . _:b544883002 . _:b544883181 "2"^^ . _:b544883013 . . . _:b544883180 "2"^^ . _:b544883012 . _:b544883183 "2"^^ . _:b544882817 . _:b544883015 . _:b544883182 "2"^^ . . _:b544883014 . _:b544883177 "2"^^ . _:b544883009 . . _:b544883176 "2"^^ . _:b544883008 . . _:b544883179 "2"^^ . _:b544883011 . _:b544883244 . . _:b544883178 "2"^^ . . _:b544883010 . . _:b544883189 "2"^^ . _:b544883021 . _:b544882885 . _:b544883188 "2"^^ . _:b544883020 . _:b544883191 "2"^^ . _:b544883023 . . _:b28799532 . _:b544883190 "2"^^ . _:b544883022 . . _:b544883185 "2"^^ . _:b544883017 . _:b544883387 . . _:b544883184 "2"^^ . _:b544883413 . _:b544883016 . . _:b544883187 "2"^^ . _:b544883019 . . _:b544883186 "2"^^ . _:b544883018 . _:b544883197 "2"^^ . _:b544883029 . _:b544883029 . _:b544883196 "2"^^ . _:b544883028 . _:b544882858 . . _:b544883199 "2"^^ . _:b544883045 . _:b544883073 . _:b544883031 . _:b544883389 . _:b544883198 "2"^^ . _:b544883030 . _:b544883606 . _:b544883193 "2"^^ . _:b544883025 . _:b544883192 "2"^^ . . _:b544883024 . _:b544883195 "2"^^ . _:b544883027 . _:b544883194 "2"^^ . _:b544883026 . _:b544883037 . _:b544882960 . _:b544883036 . _:b544883039 . . _:b544882906 . _:b544883038 . _:b544882828 . _:b544883595 . _:b544882835 . _:b544883033 . . _:b544883032 . _:b544883448 . _:b544882822 . _:b544883035 . _:b544883324 . _:b544883382 . _:b544883034 . _:b544883283 . . _:b544882982 . _:b544883045 . _:b544883385 . _:b544883044 . . _:b544883498 . _:b544883047 . _:b544883046 . _:b544883041 . _:b544883040 . _:b544883488 . . _:b544883043 . _:b544882958 . _:b544883464 . _:b544883042 . . _:b544883053 . _:b544883052 . _:b544883055 . _:b544883054 . _:b544883049 . _:b544883048 . _:b544883503 . _:b544883119 . . _:b544883051 . _:b544883330 . _:b544883050 . _:b544883153 . _:b544883061 . . _:b544883060 . . _:b544883420 . _:b544883063 . _:b544883062 . _:b544882916 . _:b544883214 . . _:b544883057 . . . _:b544882931 . _:b544883056 . . _:b544883059 . _:b544883058 . . . . _:b544883069 . _:b544883068 . . _:b544883034 . _:b544883361 . _:b544883297 . . _:b544883071 . . _:b544883070 . _:b544883065 . _:b544883569 . . _:b544883313 . _:b544883064 . _:b544883412 . _:b544883067 . _:b544883066 . _:b544883077 . _:b544883076 . . _:b544883079 . . _:b544883213 . . _:b544883078 . _:b544883304 . _:b544883085 . _:b544883073 . _:b544883157 . _:b544883351 . _:b544883072 . _:b544883075 . _:b544883074 . . _:b544883074 . . _:b544882933 . _:b544883085 . _:b544883084 . _:b544883087 . . . _:b544883086 . _:b544883104 . _:b544883456 . _:b544883081 . _:b544883080 . . . _:b544883010 . _:b544883077 . _:b544883083 . _:b544883082 . . . _:b544883093 . . . _:b544883092 . _:b544883556 . . _:b544883425 . _:b544883095 . . . _:b544882860 . _:b544883094 . _:b544883089 . . _:b544883088 . . _:b544883091 . _:b544883500 . _:b544883090 . _:b544882923 . _:b544883090 . _:b544883360 . . . _:b544883101 . _:b544883100 . _:b544882945 . . _:b544883103 . _:b544883102 . . _:b544883097 . _:b544883102 . _:b544883096 . _:b544883199 . _:b544883099 . _:b544882874 . . _:b544883378 . _:b544883098 . _:b544882880 . _:b544883109 . _:b544883108 . . _:b544883111 . . _:b544883431 . _:b544883110 . . . _:b544883105 . _:b544883226 . _:b544882995 . _:b544883104 . _:b544882820 . _:b544883107 . _:b544883446 . _:b544883106 . . . _:b544883117 . _:b544883116 . . _:b544883119 . . _:b544883118 . . . _:b544883113 . . . _:b544883112 . _:b544883115 . _:b544883583 . _:b544883467 . . _:b544883037 . _:b544883114 . _:b544883125 . . _:b544883374 . _:b544883124 . _:b544883127 . _:b544883126 . _:b544883121 . _:b544883120 . _:b544883123 . . . _:b544883122 . _:b544883133 . _:b544883212 . _:b544883132 . _:b544883110 . _:b544883135 . . _:b544883134 . _:b544883502 . . _:b544883129 . _:b544883447 . . _:b544883419 . _:b544883128 . _:b544883131 . . _:b544883130 . . . _:b544883379 . . _:b544883141 . . . _:b544883140 . _:b544883516 . _:b544883143 . _:b544883381 . . _:b544883142 . _:b544883137 . . _:b544883136 . _:b544882935 . _:b544883130 . _:b544883139 . _:b544883609 . _:b544883604 . _:b544883052 . _:b544883138 . . _:b544883557 . _:b544883149 . _:b544883148 . _:b544882887 . _:b544883400 . _:b544883151 . _:b544883243 . . _:b544883150 . . _:b544883235 . _:b544883145 . _:b544883144 . _:b544883147 . _:b544883146 . _:b544883189 . _:b544883388 . _:b544883157 . _:b544883611 . _:b544883156 . _:b544883594 . _:b544883551 . _:b544883050 . _:b544883159 . _:b544883169 . _:b544883158 . _:b544882879 . _:b544883122 . _:b544883153 . . _:b544883152 . _:b544883155 . _:b544883369 . _:b544883086 . . _:b544883154 . . _:b544883306 . _:b544883165 . _:b544883164 . . _:b544883167 . _:b544883463 . _:b544883166 . _:b544883317 . _:b544883161 . _:b544883532 . . _:b544883160 . . _:b544883163 . . . _:b544883162 . _:b544883064 . _:b544883219 . _:b544883173 . . _:b544883172 . _:b544883201 . . _:b544883175 . _:b544883174 . _:b544883169 . _:b544883063 . . _:b544883075 . _:b544883168 . _:b544883263 . _:b544883171 . _:b544883170 . _:b544883249 . _:b544883181 . _:b544883180 . _:b544883183 . _:b544883510 . . _:b544883182 . . _:b544883177 . . _:b544883176 . _:b544883179 . _:b544883444 . _:b544883178 . _:b544883537 . _:b544883521 . _:b544883189 . _:b544883188 . _:b544883252 . _:b544883191 . _:b544883120 . . _:b544883190 . _:b544883185 . . _:b544883184 . . _:b544883187 . _:b544883191 . . _:b544883415 . _:b544883186 . . . _:b544883197 . _:b544883196 . _:b544883250 . _:b544883199 . . _:b544883573 . _:b544882824 . _:b544883198 . _:b544882993 . _:b544883193 . . _:b544883192 . . _:b544882865 . _:b544883195 . _:b544883451 . . _:b544883194 . . _:b544882991 . _:b544883428 . _:b544883511 . . _:b544883196 . _:b544883599 . _:b544883326 . _:b544883208 . . _:b544883012 . . . _:b544883114 . . . _:b544883416 . . _:b544883373 . _:b544883277 . _:b544883167 . . _:b544883267 . . . . _:b544883184 . . _:b544882841 . . . . _:b544882957 . . _:b544882954 . _:b544883338 . _:b544883245 . _:b28799530 "online-only methods" . _:b544883303 . . . . . _:b544882952 . _:b544883009 . _:b544883205 . . _:b544882836 . . _:b544882912 . . _:b544883561 . _:b544882983 . . . _:b544883019 . . . . _:b544883230 . . _:b544883246 . . _:b544883305 . _:b544883178 . _:b544883601 . . _:b544883205 "2"^^ . _:b544883204 "2"^^ . _:b544883207 "2"^^ . _:b544882934 . _:b544883478 . _:b544882873 . _:b544883206 "2"^^ . . _:b544883082 . _:b544883201 "2"^^ . _:b544882864 . _:b544882964 . _:b544883200 "2"^^ . _:b544883376 . _:b544883203 "2"^^ . _:b544883469 . _:b544883572 . _:b544883202 "2"^^ . _:b544883588 . _:b544883495 . _:b544883213 "2"^^ . _:b544883212 "2"^^ . . _:b544883215 "2"^^ . _:b544882851 . _:b544883214 "2"^^ . . _:b544883209 "2"^^ . . _:b544883208 "2"^^ . . . _:b544883299 . _:b544883211 "2"^^ . _:b544883022 . . _:b544882896 . _:b544883436 . _:b544883340 . _:b544883210 "2"^^ . _:b544883221 "2"^^ . . . . _:b544883220 "2"^^ . _:b544882966 . _:b544883549 . . . _:b544883223 "2"^^ . . . _:b544883228 . _:b544883222 "2"^^ . . _:b544883359 . _:b544883217 "2"^^ . _:b544883430 . _:b544883216 "2"^^ . . _:b544883219 "2"^^ . _:b544883218 "2"^^ . . _:b544883527 . _:b544883229 "2"^^ . _:b544883571 . _:b544883228 "2"^^ . . _:b544883314 . . _:b544882949 . _:b544883231 "2"^^ . . _:b544883258 . _:b544883230 "2"^^ . _:b544883558 . _:b544883107 . _:b544883225 "2"^^ . . _:b544883224 "2"^^ . _:b544883227 "2"^^ . _:b544883226 "2"^^ . _:b544883237 "2"^^ . _:b544883236 "2"^^ . _:b544883492 . _:b544883239 "2"^^ . _:b544883248 . . _:b544883238 "2"^^ . _:b544883233 "2"^^ . _:b544883143 . _:b544883232 "2"^^ . . . _:b544883235 "2"^^ . _:b544883497 . _:b544883234 "2"^^ . . . _:b544883475 . _:b544883245 "2"^^ . _:b544883548 . . _:b544883042 . _:b544883244 "2"^^ . _:b544883247 "2"^^ . _:b544883295 . _:b544883000 . _:b544883246 "2"^^ . . _:b544883241 "2"^^ . _:b544883520 . _:b544883173 . _:b544883240 "2"^^ . _:b544883243 "2"^^ . _:b544883512 . _:b544883242 "2"^^ . . _:b544883253 "2"^^ . . _:b544883252 "2"^^ . _:b544883255 "2"^^ . . _:b544883254 "2"^^ . _:b544883067 . _:b544883105 . . _:b544883249 "2"^^ . _:b544883406 . . _:b544883248 "2"^^ . _:b544883080 . _:b544883251 "2"^^ . . . . _:b544883250 "2"^^ . _:b544882981 . . _:b544883261 "2"^^ . . _:b544883260 "2"^^ . . _:b544883068 . _:b544883263 "2"^^ . . _:b544883262 "2"^^ . _:b544883257 "2"^^ . _:b544883256 "2"^^ . _:b544883259 "2"^^ . _:b544883258 "2"^^ . _:b544882807 . _:b544883269 "2"^^ . _:b544883522 . . _:b544883268 "2"^^ . _:b544882950 . _:b544883331 . . _:b544883097 . _:b544883271 "2"^^ . . _:b544883270 "2"^^ . _:b544883265 "2"^^ . _:b544883264 "2"^^ . _:b544882813 . _:b544883267 "2"^^ . _:b544882812 . _:b544883266 "2"^^ . _:b544882815 . _:b544883277 "2"^^ . _:b544882814 . _:b544883088 . _:b544883276 "2"^^ . _:b544882809 . _:b544883279 "2"^^ . _:b544882808 . _:b544883372 . _:b544883278 "2"^^ . _:b544882811 . . _:b544883273 "2"^^ . _:b544882810 . _:b544883272 "2"^^ . _:b544882821 . _:b544883275 "2"^^ . _:b544882820 . _:b544883490 . _:b544883274 "2"^^ . _:b544882823 . . . _:b544883285 "2"^^ . _:b544882822 . _:b544882867 . _:b544883284 "2"^^ . _:b544883156 . _:b544882817 . . _:b544883287 "2"^^ . _:b544882816 . _:b544883286 "2"^^ . _:b544882819 . _:b544883281 "2"^^ . _:b544882818 . _:b544883280 "2"^^ . _:b544882829 . . _:b544883590 . . . _:b544883283 "2"^^ . _:b544883065 . _:b544882828 . . _:b544883282 "2"^^ . _:b544882831 . _:b544883345 . . . _:b544883293 "2"^^ . _:b544882830 . _:b544883545 . _:b544883402 . _:b544883292 "2"^^ . _:b544882825 . _:b544883295 "2"^^ . _:b544882824 . . _:b544883294 "2"^^ . _:b544882827 . _:b544883289 "2"^^ . _:b544882826 . _:b544883288 "2"^^ . _:b544882837 . _:b544882984 . . _:b544883291 "2"^^ . _:b544882836 . . _:b544883530 . _:b544883290 "2"^^ . . _:b544883567 . _:b544882839 . _:b544883301 "2"^^ . _:b544882908 . _:b544882838 . _:b544883300 "2"^^ . _:b544882833 . _:b544883303 "2"^^ . _:b544883365 . _:b544882832 . _:b544883302 "2"^^ . _:b544882835 . _:b544883297 "2"^^ . _:b544882834 . . _:b544882884 . _:b544883296 "2"^^ . _:b544882845 . _:b544883299 "2"^^ . _:b544882844 . _:b544883298 "2"^^ . _:b544882847 . . . _:b544883309 "2"^^ . _:b544882846 . _:b544883308 "2"^^ . _:b544882841 . _:b544883311 "2"^^ . _:b544882840 . . _:b544882905 . _:b544883310 "2"^^ . _:b544882843 . _:b544883305 "2"^^ . _:b544882842 . _:b544883060 . . . _:b544883304 "2"^^ . _:b544882853 . _:b544883307 "2"^^ . _:b544882852 . . _:b544883306 "2"^^ . _:b544882855 . . _:b544883317 "2"^^ . _:b544882854 . _:b544883286 . . _:b544883316 "2"^^ . _:b544882849 . _:b544883322 . . _:b544883319 "2"^^ . . _:b544882848 . . _:b544883318 "2"^^ . _:b544882851 . _:b544883313 "2"^^ . _:b544882850 . _:b544883234 . _:b544882881 . _:b544883312 "2"^^ . _:b544882861 . . _:b544882992 . _:b28799528 "assay (see Fig. 3 and supplementary notes) following the representative marking of stem cells at the crypt base, and the line shows the predictions of the strictly one-dimensional neutral drift dynamics model introduced in Ref. [>>8<<] with a stem cell loss replacement rate of 0.24 per day and a total of 8 stem cells." . _:b544883315 "2"^^ . _:b544883091 . _:b544882860 . . _:b544883314 "2"^^ . _:b544882863 . _:b544883325 "2"^^ . _:b544882862 . . _:b544883324 "2"^^ . _:b544882857 . _:b544883327 "2"^^ . _:b544882856 . . _:b544882818 . _:b544882898 . _:b544883326 "2"^^ . _:b544883014 . . _:b544882859 . _:b544883321 "2"^^ . _:b544882858 . _:b544883316 . . _:b544883320 "2"^^ . _:b544882869 . _:b544883323 "2"^^ . _:b544882868 . . . . _:b544883322 "2"^^ . _:b544882871 . _:b544883035 . _:b544883333 "2"^^ . _:b544882870 . . _:b544883506 . _:b544883163 . _:b544883332 "2"^^ . _:b544882865 . . _:b544883335 "2"^^ . _:b544882864 . _:b544883334 "2"^^ . _:b544882867 . _:b544883587 . _:b544882903 . _:b544883329 "2"^^ . _:b544882866 . _:b544883328 "2"^^ . . _:b544882877 . _:b544883204 . _:b544883331 "2"^^ . _:b544882876 . _:b544883330 "2"^^ . _:b544882879 . . . _:b544883341 "2"^^ . _:b544882878 . _:b544883383 . _:b544883198 . _:b544883340 "2"^^ . . _:b544882873 . _:b544882998 . _:b544882978 . . _:b544883343 "2"^^ . _:b544882872 . _:b544883342 "2"^^ . _:b544882875 . _:b544883115 . _:b544883209 . _:b544883337 "2"^^ . _:b544882874 . _:b544883025 . . _:b544883336 "2"^^ . _:b544882885 . _:b544883318 . _:b544883339 "2"^^ . . _:b544882884 . . . _:b544883338 "2"^^ . _:b544882887 . _:b544883563 . . _:b544883349 "2"^^ . _:b544882886 . _:b544883348 "2"^^ . _:b544882881 . . _:b544883351 "2"^^ . _:b544882880 . _:b544883072 . _:b544883274 . _:b544883350 "2"^^ . . _:b544882883 . _:b544883345 "2"^^ . _:b544882882 . _:b544883294 . _:b544883524 . _:b544883344 "2"^^ . _:b544882893 . . _:b544883347 "2"^^ . _:b544882892 . _:b544883301 . _:b544883346 "2"^^ . _:b544882895 . . _:b544883357 "2"^^ . _:b544882894 . _:b544883236 . . _:b544883356 "2"^^ . _:b544882889 . _:b544883128 . _:b544883329 . _:b544883359 "2"^^ . . _:b544882888 . _:b544883358 "2"^^ . _:b544882891 . . _:b544882909 . _:b544883353 "2"^^ . _:b544882830 . _:b544882890 . . _:b544883352 "2"^^ . _:b544882901 . _:b544883355 "2"^^ . _:b544882900 . _:b544883354 "2"^^ . _:b544882975 . _:b544883559 . _:b544882903 . _:b544882870 . _:b544883365 "2"^^ . _:b544883193 . _:b544882902 . _:b544883364 "2"^^ . _:b544882897 . _:b544883528 . _:b544883367 "2"^^ . _:b544882896 . _:b544883366 "2"^^ . _:b544882899 . _:b544883054 . _:b544883183 . _:b544883361 "2"^^ . _:b544882898 . _:b544883585 . _:b544883360 "2"^^ . _:b544882909 . . _:b544883186 . _:b544883363 "2"^^ . _:b544882908 . . _:b544883408 . _:b544883362 "2"^^ . _:b544882911 . _:b544882833 . . _:b544883373 "2"^^ . _:b544882910 . . _:b544883358 . _:b544883372 "2"^^ . _:b544883021 . _:b544882905 . . _:b544883375 "2"^^ . _:b544882904 . _:b544883519 . . _:b544883374 "2"^^ . _:b544882907 . . _:b544883369 "2"^^ . _:b544882906 . _:b544883368 "2"^^ . . _:b544882917 . _:b544883514 . _:b544883371 "2"^^ . _:b544882916 . _:b544883096 . _:b544883370 "2"^^ . . _:b544882919 . _:b544882842 . . _:b544883381 "2"^^ . _:b544883371 . _:b544882918 . . _:b544883380 "2"^^ . _:b544882913 . _:b544883383 "2"^^ . _:b544882912 . _:b544883224 . _:b544883094 . _:b544883382 "2"^^ . _:b544882915 . _:b544883377 "2"^^ . _:b544882914 . . _:b544883476 . . . . _:b544883376 "2"^^ . _:b544882925 . . _:b544883333 . _:b544883379 "2"^^ . _:b544882924 . _:b544883378 "2"^^ . _:b544882927 . _:b544883389 "2"^^ . _:b544882926 . . _:b544883388 "2"^^ . _:b544882921 . . _:b544883101 . _:b544883391 "2"^^ . _:b544882920 . . _:b544883390 "2"^^ . _:b544882923 . _:b544883385 "2"^^ . _:b544882922 . _:b544883384 "2"^^ . _:b544882933 . _:b544883387 "2"^^ . _:b544882932 . _:b544883078 . . _:b544883386 "2"^^ . _:b544882935 . _:b544883397 "2"^^ . _:b544882934 . . _:b544882996 . _:b544883438 . _:b544883396 "2"^^ . _:b544882929 . . _:b544882871 . _:b544883133 . . _:b544883399 "2"^^ . _:b544882928 . _:b544883339 . _:b544883398 "2"^^ . _:b544882931 . _:b544883265 . _:b544883393 "2"^^ . _:b544882930 . _:b544883287 . _:b544883392 "2"^^ . _:b544882941 . _:b544883395 "2"^^ . _:b544883486 . . _:b544882940 . _:b544883613 . . _:b544883394 "2"^^ . _:b544882943 . . _:b544883405 "2"^^ . _:b544882942 . _:b544882889 . . _:b544883404 "2"^^ . _:b544882937 . . _:b544883036 . _:b544883407 "2"^^ . _:b544882936 . _:b544883406 "2"^^ . _:b544882939 . _:b544883401 "2"^^ . _:b544882938 . . . _:b544883400 "2"^^ . . _:b544883352 . _:b544883160 . _:b544883403 "2"^^ . . _:b544883402 "2"^^ . . . . _:b544883413 "2"^^ . . _:b544883412 "2"^^ . _:b544883415 "2"^^ . _:b544883256 . _:b544883414 "2"^^ . _:b544882941 . . _:b544883409 "2"^^ . . _:b544883408 "2"^^ . . _:b544883411 "2"^^ . _:b544883603 . _:b544883410 "2"^^ . . _:b544883421 "2"^^ . _:b544883420 "2"^^ . _:b544883477 . . _:b544883423 "2"^^ . _:b544883422 "2"^^ . . _:b544883417 "2"^^ . _:b544883166 . _:b544883416 "2"^^ . . _:b544883407 . _:b544883419 "2"^^ . _:b544883439 . _:b544882924 . _:b28799531 "To obtain R26R-Confetti; Lgr5-EGFP-Ires-CreERT2 mice, R26R-Confetti>>7<< mice were crossed with Lgr5-EGFP-Ires-CreERT21." . _:b544883418 "2"^^ . . _:b544883429 "2"^^ . . _:b544883428 "2"^^ . _:b544883431 "2"^^ . _:b544883430 "2"^^ . _:b544883425 "2"^^ . . _:b544883424 "2"^^ . _:b544883427 "2"^^ . . . . . _:b544883089 . _:b544883426 "2"^^ . _:b544883116 . _:b544883437 "2"^^ . _:b544883436 "2"^^ . _:b544883439 "2"^^ . _:b544883438 "2"^^ . _:b544883257 . _:b544883433 "2"^^ . . _:b544883172 . _:b544883432 "2"^^ . . _:b544882959 . . _:b544883435 "2"^^ . . _:b544882910 . _:b544883434 "2"^^ . . . _:b544883445 "2"^^ . _:b544883444 "2"^^ . . . . _:b544883447 "2"^^ . . _:b544883446 "2"^^ . . _:b544883051 . _:b544883441 "2"^^ . . _:b544883440 "2"^^ . . _:b544883367 . _:b544883443 "2"^^ . _:b544883442 "2"^^ . _:b544882986 . _:b28799528 . _:b544883341 . _:b544883453 "2"^^ . . _:b28799529 . _:b544883452 "2"^^ . _:b544882930 . _:b544883455 "2"^^ . . . . _:b544883454 "2"^^ . . _:b544883418 . . _:b544883449 "2"^^ . _:b544883448 "2"^^ . . . . . _:b544883451 "2"^^ . _:b544882985 . . _:b544883450 "2"^^ . _:b544883597 . _:b544883461 "2"^^ . . _:b544883460 "2"^^ . _:b544882882 . _:b544883463 "2"^^ . . _:b544882849 . . _:b544883462 "2"^^ . . _:b544883457 "2"^^ . . _:b544883456 "2"^^ . _:b544883459 "2"^^ . _:b544883574 . _:b544883458 "2"^^ . _:b544882914 . _:b544883469 "2"^^ . . _:b544883468 "2"^^ . _:b544883471 "2"^^ . _:b544883344 . _:b544883470 "2"^^ . _:b544883465 "2"^^ . _:b544883464 "2"^^ . _:b544883467 "2"^^ . _:b544882811 . _:b544883466 "2"^^ . _:b544882846 . _:b544883477 "2"^^ . _:b544883592 . _:b544883106 . _:b544883142 . _:b544883476 "2"^^ . _:b544883222 . _:b544882897 . _:b544883479 "2"^^ . _:b544883478 "2"^^ . . _:b544883473 "2"^^ . _:b544883472 "2"^^ . _:b544883475 "2"^^ . . _:b544883474 "2"^^ . . . _:b544883485 "2"^^ . _:b544883484 "2"^^ . . _:b544883328 . _:b544883129 . _:b544883487 "2"^^ . _:b544883491 . _:b544883486 "2"^^ . _:b544883481 "2"^^ . . _:b544883480 "2"^^ . . _:b544883483 "2"^^ . _:b544883140 . _:b544883482 "2"^^ . _:b544883493 "2"^^ . . _:b544883492 "2"^^ . _:b544883552 . _:b544882929 . _:b544882868 . _:b544883495 "2"^^ . _:b544883494 "2"^^ . _:b544883489 "2"^^ . . _:b544882821 . _:b544883488 "2"^^ . _:b544883491 "2"^^ . _:b544883490 "2"^^ . _:b544883501 "2"^^ . _:b544883500 "2"^^ . _:b544883459 . _:b544883503 "2"^^ . _:b544883455 . _:b544883502 "2"^^ . _:b544883497 "2"^^ . _:b544883013 . _:b544883496 "2"^^ . . _:b544883499 "2"^^ . _:b544883001 . _:b544883498 "2"^^ . _:b544883509 "2"^^ . . _:b544883508 "2"^^ . _:b544883511 "2"^^ . _:b544883510 "2"^^ . _:b544883118 . _:b544883505 "2"^^ . . _:b544883504 "2"^^ . _:b544883507 "2"^^ . . _:b544883506 "2"^^ . _:b544882812 . "PMC0" . _:b544882994 . _:b544882907 . _:b544883517 "2"^^ . _:b544883291 . _:b544883380 . _:b544882810 . _:b544883516 "2"^^ . _:b544883519 "2"^^ . _:b544882979 . . . _:b544883518 "2"^^ . _:b544883513 "2"^^ . _:b544883542 . _:b544883512 "2"^^ . _:b544883515 "2"^^ . _:b544883514 "2"^^ . . . . _:b544883525 "2"^^ . . _:b544883524 "2"^^ . . _:b544883462 . _:b544883038 . _:b544883527 "2"^^ . . _:b544883526 "2"^^ . . _:b544883521 "2"^^ . _:b544882962 . . _:b544883207 . _:b544883520 "2"^^ . . _:b544882862 . _:b544883284 . _:b544883523 "2"^^ . _:b544882915 . . _:b544883522 "2"^^ . _:b544883266 . . _:b544883533 "2"^^ . _:b544882947 . . _:b544883532 "2"^^ . . _:b544883535 "2"^^ . _:b544883242 . . _:b544883534 "2"^^ . . _:b544883529 "2"^^ . _:b544883528 "2"^^ . . . _:b544883531 "2"^^ . _:b544883530 "2"^^ . _:b544883023 . . _:b544882965 . _:b544883541 "2"^^ . _:b544883540 "2"^^ . _:b544883030 . _:b544883473 . _:b544883543 "2"^^ . _:b544883043 . _:b544883542 "2"^^ . _:b544883537 "2"^^ . . _:b544883410 . _:b544883290 . . . _:b544883536 "2"^^ . . _:b544883539 "2"^^ . _:b544883538 "2"^^ . _:b544883549 "2"^^ . _:b544882844 . . _:b544883548 "2"^^ . _:b544883240 . . . _:b544883551 "2"^^ . _:b544882925 . _:b544883150 . . _:b544883254 . . _:b544883550 "2"^^ . . _:b544883545 "2"^^ . _:b544883553 . _:b544883544 "2"^^ . . _:b544883547 "2"^^ . _:b544883058 . _:b544883550 . _:b544883546 "2"^^ . _:b544883557 "2"^^ . . . _:b544883556 "2"^^ . . . _:b544883015 . . . _:b544883559 "2"^^ . . _:b544883558 "2"^^ . _:b544882911 . _:b544883553 "2"^^ . _:b544883509 . _:b544883552 "2"^^ . _:b544883285 . . _:b544883555 "2"^^ . . _:b544883474 .